320 | AI cancer curing breakthrough, context is taking main stage, huge funding rounds, and more important AI news ending week of August 21, 2026

22 Aug 2026 · 55 min · 27 chapters

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In short

Weekend AI news roundup (week of Aug 21, 2026) focused on (1) AI-enabled cancer breakthroughs, (2) why “context” beats model-only improvements, (3) safety/security concerns, plus rapid-fire examples of AI productivity, voice, drug discovery, retail trust, and major funding/investment.

Guest backgrounds

No guests are interviewed in this episode. Hosts are Isar and Maitlis (Dario Amodei is quoted; Greg Brockman is quoted).

Key claims

  • Cancer: AI-personalized mRNA/neoantigen approaches are showing first major Phase 3 positives; AI also improves early detection and surgery guidance, but it’s “not a cure yet.”
  • Context: Anthropic/OpenAI/Harvey product updates show performance gains come from giving AI richer task context, tools, and process memory.
  • Security: open-weight cyber-capable models may accelerate threats; “private safety processing” aims to detect misuse without exposing customer data to humans.

Notable examples

  • Merck/Moderna InterPATH 001 Phase 3: 1137 patients; first positive Phase 3 for neoantigen therapy and mRNA cancer therapy.
  • Univ. of Southampton SensegNet: 330k centrosomes; finds two distinct cancer processes; open source.
  • Mayo Clinic pancreatic AI: detects pancreatic cancer ~16 months early (sometimes >2 years).
  • Harvey 2: legal “spaces” with matter context + task history/preferences.
  • OpenAI “Computer History” (Mac): event-stream timeline for automations; limited privacy capture.
  • Rapid fire: Asana Codex removes “Enzyme” testing system (2 weeks vs 5 years); Slack Code; Anthropic ProteinBinder (93% success); major funding (NVIDIA/finance platform, Stripe acquiring OpenRouter for $7B, Databricks $5B round).

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

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Shifting Topics for the Week

0:45 to 1:06

Discussion on the main topics for today's episode, including AI and cancer.

“in some cases to detect cancer significantly earlier in order to dramatically increase our chances of not having people die from cancer.”

AI's Potential to Cure Cancer

1:06 to 1:50

Exploration of AI's advancements in cancer detection and treatment.

“And so that is going to be the second topic we're going to talk about.”

Dario Amadei's Perspective on AI Risks

1:50 to 4:48

Discussion on public perception of AI and criticisms of AI companies.

“So that's going to be our following topic in the rapid fire.”

Merck and Moderna's Cancer Therapy Breakthrough

4:48 to 7:48

Details on the InterPATH 001 trial and its implications for cancer treatment.

“which I'm not sure if Dario knew about ahead of time or not, But the biggest, biggest one came from Merck and Moderna.”

University of Southampton's AI Discoveries

7:48 to 10:40

Insights into AI's role in analyzing cancer and identifying survival predictors.

“Stefan Bansel, the CEO of Moderna, said, These FATE3 findings represent a pivotal moment for the field of cancer research.”

AI in Cancer Detection and Surgery

10:40 to 12:52

Overview of AI's use in improving cancer detection and surgical outcomes.

“Institute of Life Sciences at University of Southampton said these two things that happened this past week connect to another one that was published just a few months ago on April 28th of this year.”

AI's Promising Role in Oncology

12:52 to 14:00

Discussion on the growing importance of AI in cancer treatment and research.

“I don't have a clue what the other half of the sentence means, but what it's showing you is that AI is becoming a center point in oncology and the fight against cancer.”

AI Advancements in Cancer Research

14:00 to 16:18

Explore how AI is revolutionizing cancer treatment and its implications.

“First of all, this is to me extremely exciting, promising, makes me really really happy on a personal level.”

The Importance of Context in AI

16:18 to 19:55

Learn how context-aware AI enhances performance across various platforms.

“is now the most critical thing to achieve results and not having a better model is necessarily the right way to go.”

Innovations in AI Personalization

19:55 to 28:00

Discover innovative AI features improving communication and efficiency.

“But now back to Anthropic and this segment.”
Show all 27 chapters

Understanding the Importance of Context in AI

28:00 to 30:15

Learn why context is critical for the effective use of AI in legal work.

“that probably most humans will not like to do anyway.”

Rethinking Work Processes with AI

30:15 to 31:55

Explore how AI can change traditional work methods for better efficiency.

“And on the other hand, I think it's missing a much bigger point.”

Cybersecurity Concerns with Open Source AI Models

31:55 to 35:30

Discuss the cybersecurity risks posed by open-source AI models and their implications.

“As I mentioned in the beginning, we're going to start with some safety and security thing.”

OpenAI's New Safety Features and AI Developments

35:30 to 38:06

Learn about OpenAI's private safety processing and recent advancements in AI.

“And the idea is to make sure that companies' data is never exposed to human eyes inside of OpenAI.”

Significant AI Releases Impacting Audio and Voice Processing

38:06 to 40:28

Discover the latest advancements in audio AI models and their implications for businesses.

“I don't think it's as good as Whisperflow.”

AI's Role in Accelerating Drug Discovery

40:28 to 42:05

Examine how AI is revolutionizing the drug discovery process and its impact on healthcare.

“crazy amounts of money and hence you didn't even consider them and now you can do that.”

AI in Chemical Analysis: A Breakthrough

42:05 to 42:54

Learn how AI is revolutionizing chemical analysis and design.

“Basically, 14 out of 15 actually work correctly.”

Consumer Trust in AI for Purchases

42:54 to 43:32

Explore consumer attitudes towards AI in purchase decisions.

“world, a new RTB House survey of over 1 ,800 consumers across US, UK, Japan, and France revealed that shoppers are increasingly trusting AI tools to assist with purchasing decisions.”

AI Enhancements in Coding with Replit

43:32 to 44:36

Discover how Replit's new features enhance coding efficiency.

“The only thing that ranks higher than that is friends and family, which rank at 50.”

Massive Funding for AI Infrastructure

44:36 to 45:56

Understand the recent financial investments in AI technology.

“And by integrating it into Replit, they're now able to perform these tasks again at a 30x higher efficiency than they were able to do before.”

Stripe's Acquisition of OpenRouter

45:56 to 47:22

Learn about Stripe's significant acquisition and its implications.

“Staying on the really crazy numbers, Stripe just agreed to acquire OpenRouter for$7 billion.”

Databricks and Higgsfield's Impressive Raises

47:22 to 48:46

Examine the financial successes of Databricks and Higgsfield.

“they raised$5 billion instead, 5x from investors on a very short amount of time, which gets the Databricks overall investments to 20 over the past 20 months.”

Etched and River's Major Funding Rounds

48:46 to 49:44

Explore the funding journeys of Etched and River in AI.

“delivered their hardware to their very first client.”

Lovable's Growth and Valuation

49:44 to 50:23

Discuss Lovable's financial growth and market positioning.

“rather than be relying on a third-party environment.”

Sharing and Newsletter Promotion

50:23 to 51:08

Learn about the importance of sharing the podcast and joining the newsletter.

“there is a lot more news to report this week, but I can't report it all.”

AI's Role in Workforce Management

51:08 to 53:04

Investigate AI's involvement in employee management and legislation.

“But now the last two interesting, weird things that happened this week.”

AI-Generated Content and Ethical Concerns

53:04 to 54:47

Examine the implications of AI-generated content in society.

“Again, not sure about this particular incident and what I feel about it.”
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Transcript

Automatic transcript. May contain errors.

0:00Hello, and welcome to a weekend news episode of the Leveraging AI podcast, the podcast that shares practical ethical ways to leverage AI to improve efficiency, grow your business and advance your career. This is Isar, Maitlis, your host, and we had a very interesting week. And initially, I thought that the main topic today is going to be data centers. What's going in that space is absolutely crazy, mostly because it became political and very hardcore political. Maybe the biggest bipartisan agreement right now is against data centers. But then other things happened that I thought would be more interesting.

0:33So I decided to hold off the data center story to next week. Hopefully nothing crazy happens this week. But we're going to start with maybe the most exciting news I have seen from AI ever, which is a real opening, still not a solution, but a real opening, a real opportunity for AI to cure cancer and in some cases to detect cancer significantly earlier in order to dramatically increase our chances of not having people die from cancer. So since I think this is maybe the most important news I can think of, that's going to be our first topic. We're then going to talk about how extreme is the focus right now on context versus model and how the labs and others are investing in that direction.

1:19and how you should probably too, because what I see in my work that as I develop context layers, actual knowledge graph that connects all the things that I'm doing together, the AI just becomes significantly better at its abilities to do tasks for me and automate more and more of the things I'm doing in my companies. And so that is going to be the second topic we're going to talk about. Then we can spend a week, I guess, without talking a little bit about safety and security concerns. We're going to talk about that in the rapid fire section. That's going to be the opening. We have a few really good examples on how AI actually accelerates and achieves real things in real life for real companies.

1:57So that's going to be our following topic in the rapid fire. And then we have a very long section that's going to be really, really quick. I'm going to just run through it that shows you how much these actual real achievements in real life drive crazy investments into this field. Literally in the last 10 days, I've seen more investments or commitments or M &A activity in hundreds of millions or billions or hundreds of billions, as you will see, that I've ever seen in my life and probably more than I've seen in any quarter in my life. So we're going to talk about that. So basically, as always, we have a lot to talk about.

2:33So let's get started. To start the first story, I'm actually going to go back to last Saturday. last saturday dario amade went on x and actually wrote two long interesting segments the first one is more about regulation and governance of these models and where we stand and he did that as part of an exchange with another guy on x named gavin baker i'm not going to dive into that but the second one i found more interesting especially in light of what was revealed later that week So in the second section, Dario was talking about how people do not like AI right now, how the messaging around AI is negative and how his personal messaging has been perceived as negative.

3:21And one of the things he was mentioning is that he lost his father to hepatitis C only a few years before the development of direct acting antivirals, which cure 95 % of patients and probably would have cured him. And then he continues, I do agree that the public has a negative view of AI and that is a big problem, but I don't think it is primarily caused by me or any other AI leader warning about AI risks. I think it's fundamentally a crisis of trust. And then he goes and talks more about it, but then he continues, and I'm quoting again, at this point, saying that AI will cure cancer is more a cliche than inspiring, and most people think it's deceptive.

4:01The thing that will work is actually curing cancer. So again, this is a quote from Dario Amadei from last Saturday. The following sentence there says, I think by far the most accurate criticism of AI companies, including Anthropic, is that we haven't yet delivered on our big promises to benefit the world. That is totally on us. And I think this is the criticism you should be making instead of all this stuff about messaging and marketing. So this is Dario's viewpoint. He's saying, yes, we should be criticized because we are investing tens of billions of dollars across the board, driving the world crazy, and we haven't delivered any real results that benefit the world.

4:44That's basically the summary of what Dario is saying. Though we continued with very exciting news in that field, which I'm not sure if Dario knew about ahead of time or not, But the biggest, biggest one came from Merck and Moderna. So they released the results of what they called InterPATH 001 Phase 3 trial. The trial that they did enrolled 1137 patients with completely receded stage 2 B1 soma, which kills a lot of people, sadly. And it is the first ever positive Phase 3 readout for an individual neoantigen therapy. It is the first ever positive phase three readout for an mRNA-based cancer therapy.

5:27Now, to put things in perspective, phase 2B of a five-year data set of these tools have risk of recurrence or death reduced by 40 versus the historic kind of cures or processes that we had to try to fight this cancer, risk of distant metatasis or death reduced by 59 % versus the previous drug alone. So how does this thing work? They take the actual patient's tumor DNA, they run it through an AI process that identifies the patient's specific mutation in specific genes, and then instructs the immune system to build proteins targeting these unique cancer cells. Every dose is built for one patient.

6:09No two patients are the same because the mutations are never exactly the same. And this is now proven at a phase three scale for the first time ever. The ability to actually target specific gene mutations that can be targeted specifically. If you think about how we are fighting cancer right now, we are basically killing a lot of cells in the body, either through chemo or radiation. And part of those, we're trying to focus as much as we can on regular cells. This is, in many, many cases, first of all, extremely uncomfortable to the people going through this therapy. And in many cases, not effective.

6:45And while it is definitely improving the life expectancy, it is not improving it by a lot. and it's making those people miserable for a while while they're going treatment, which they may need to go again and again and again. This thing is completely different. It specifically targets only the cancer cells in a very direct and specific way. This is not a cure yet. It is not delivered as a drug that people can use tomorrow. I'm not sure how it is scalable. If you need to generate this per person every single time, I'm not sure how much money it's going to cost. All of that are still questions that need to be answered.

7:21But there is a crack in the wall. There is a door that shows us that using AI to analyze the actual changes, the mutations of genes inside cancer cells can be targeted by building individual mRNA vaccines that will be personalized to that particular cancer and can actually deliver a real cure. Stefan Bansel, the CEO of Moderna, said, These FATE3 findings represent a pivotal moment for the field of cancer research. For many years, the idea of creating mRNA treatment designed specifically for an individual patient's cancer was aspirational. We are now helping turn that vision into reality. Dr. Ryan Sullivan, the director of medical oncology at Mass General Birmingham Cancer Institute, said, it is a big deal in the field in general.

8:16With this positive study, there's hope and likely investment to follow that these approaches may change the way we treat cancer more broadly. So again, it's not a cure yet, but it opens the door for a real potential direction that can lead to real cure for cancer that is going to be significantly more effective than everything we are doing right now. But this was just one example this week. The other one came from University of Southampton with their SensegNet platform, which is an open source AI that analyzed 330 ,000 centrosomes across 911 tumor specimens from 127 breast cancer patients. What the AI was able to discover across this huge number of samples, it is two specific abnormalities.

9:10Why is that a big deal? Because for 100 years, centrosome abnormalities have been recognized as the hallmark of cancer and treated as a single phenomenon. And now this data shows it's actually two separate processes that are happening, not just one, which means, again, higher chances of targeting them correctly because we're starting to understand the mechanisms in a more detailed way. Why is that possible? Because AI can scan through 330 ,000 examples and actually find the needles in the haystack, find the things in way they are the same, which humans are practically cannot do it at that scale at a level of accuracy that makes any difference.

9:52Now, what they found is that based on these kind of tests, they can now predict the chances of survival much, much, much earlier and be able to use this information in order to develop more specific. So the idea is this technology can identify high-risk patients much earlier. It enables matching the patient's drugs and targeting the centrosome functions that could lead to cancer in these specific people that are at a much higher risk. Now, again, this is a open source software that anybody in the field now has access to and can build additional research on top of it. By the way, they've tested it beyond breast cancer and demonstrated potential applicability in kidney, colon, and appendix cancers as well.

10:39Dr. Salah Elias of the School of Biological Science Institute of Life Sciences at University of Southampton said these two things that happened this past week connect to another one that was published just a few months ago on April 28th of this year. Mayo Clinic pancreatic cancer AI tool was able to look at CP scans and detect pancreatic cancer nearly three out of four cases, approximately 16 months before actual clinical diagnosis happens by humans. And in some cases, detecting suspicious patterns more than two years before diagnosis actually happened in real patients. The detection rate nearly doubled those of specialist radiologists reviewing the same exact scans.

11:27Now, to put things in context, pancreatic cancer is among the deadliest cancers that exist today because it's almost always caught late. A 16-month average lead puts us in a completely different survivability path for people who are detected early. And there's another example recently on how AI helps us fight cancer, which is a product called Clare, which got an FDA pre-market approval just in July of this year, is helping in breast cancer surgery and helping by allowing real-time understanding of exactly what needs to be removed and how. So the problem that it solves is that currently approximately 300 ,000 breast cancer surgeries performed annually in the U.S.

12:13alone. The problem is about 20%, roughly 60 ,000 patients have to undergo a second surgery because the margins weren't clear the first time. This new product called Clare is a real-time assessment tool designed directly to reduce that number dramatically by allowing the doctors in real time to know exactly what to do and what not to do during surgery, which means a lot less people will have to undergo a second surgery, A, increasing their chances of survival, and B, reducing patient trauma and recovery times and cost, etc., everything that comes from having to go a second surgery. And this is now a global trend.

12:54In the American Society of Clinical Oncology highest profile annual consensus meeting that happened, just concluded earlier this month, the closing session focused on convergence of liquid biopsy, AI, and molecular biomarker profiling. I don't have a clue what the other half of the sentence means, but what it's showing you is that AI is becoming a center point in oncology and the fight against cancer. And we are getting more and more signals that AI can help us in, first of all, detecting cancer, second, fighting cancer while it's happening, and third, help doctors in the operating room as they're doing operations to remove cancer from the body.

13:37All of these are very positive signs that it's actually helping us, that AI is actually helping us fight cancer right now in much more effective ways with a very, very big promise for the future. Now, yes, there's going to be more trials and yes, we have to figure out, but the path is starting to become clear on where we can go with AI as far as treating cancer. And I assume in a very similar way, major other diseases as well. Now, I want to connect a few dots here. First of all, this is to me extremely exciting, promising, makes me really really happy on a personal level. I've lost my aunt to cancer and I loved her very much.

14:16And I know most people around the world, once you get to a certain age, you lost somebody to cancer. That's just the way it is right now. If we can change the statistics, forget about eliminate cancer. If we can change the statistic dramatically, this is a global world game changer for many, many, many people, the people who are fighting the disease themselves and their loved ones who are a part of that horrific journey that so many people have to go through. So I'm really excited about these news. But the other half of it, which we have to be fair about, does this really connect directly to what Dario Amadei said?

14:50And the answer is not really, because yes, we are making big headways in this week, very big steps in using AI to help fight cancer. But I don't think it has anything to do with anything that Anthropic or OpenAI did, right? The reality is this research and all the research we have talked about in this particular segment has all started years ago. They've all been using AI to figure out mRNA way before Anthropic launched and way before ChatGPT potentially launched GPT-3 back in November of 2022. However, what OpenAI and Anthropik and Gemini and so on were able to do is to provide significantly better infrastructure, compute algorithms, et cetera, et cetera, to the AI field that is accelerating those capabilities dramatically compared to if it did not happen.

15:46So while I don't think Dario can take credit now and say, hey, look, we're curing cancer and this should bring positive headwinds to AI in the world. I do think that everything that is happening in the AI space right now, across the board, from hardware to algorithm to collaborations to research to all these things, is playing a big role and is a factor in accelerating of research, scientific research, including in healthcare, that will lead to better lives for people around the planet. And this is a great way to start this weekend news. The second thing I want to talk about in a similar way of connecting the dots through what otherwise would be single individual pieces of news that tell a bigger story is the story that context-aware AI, that building the right context around AI is now the most critical thing to achieve results and not having a better model is necessarily the right way to go.

16:41So this week, three separate announcements from Anthropic, OpenAI, and Harvey are all telling that story. And that is what we're going to dive into now. Anthropic published a detailed case study showing how its own sales team cut manual work by percent, 7-0, by using Cloud Cowork to help their people connect the dots between different systems, Salesforce, Apollo, Common Room, and Gong in order to help them communicate with clients and potential clients in a much more effective way. In this blog from Anthropic, they gave multiple examples. One of them, John Albert, BDR at Anthropic, daily inbox management, used to take five hours, now is almost zero manual work.

17:23Accounts manage simultaneously over a hundred. And the vehicle that is doing this and delivering this is Claude Cowork, running five scheduled skills, an inbox scanner, a no-show prospect notifier, a lead personalization tool, a Salesforce pipeline updater in an overnight account. How this thing works? Inbox scanner drafts customer replies from a sales knowledge base. Pipeline updater proposes stage changes with evidence. Overnight account prospector runs analysis across Salesforce Apollo common room gong and internal data warehouses all at the same time trying to find the needles in the haystack and all five of them run on a schedule.

18:05No humans initiates them and they just works. I have similar systems in my company and I can tell you that it is magical. When I show up in the morning, there is a report waiting for me. It's not actually sending the emails on its own. It's not actually updating the CRM on its own, even though I can easily set it this way. But what I have is I have a brief ready for me to go that tells me what new opportunities arise. That shows me all the critical emails I have to send today, including drafts ready for me to review. And it's showing me all the discrepancies that has evolved overnight or things that it seems we need to update in the CRM compared to what it's learning from the calls that I had, the emails that I've exchanged, meetings that I have on the calendar, and so on.

18:45A very similar concept to what Anthropic has developed, and it changed the way I work. I went from chasing emails and missing a lot of really critical stuff to at 8am or 8.10, I've already sent all the most important emails that I have to send that day that make the most amount of impact to the future of my business. This is something that each and every one of you can build relatively easily if you know how to build these things. So it's not Anthropica's built for themselves, something that nobody else can build. You can do this by using Cloud Cowork. By the way, if you want to learn how to do these kind of things, you can join our course, which the next cohort that we're opening right now is in November of this year.

19:25So I know this as far in the future. But if you don't join that, then the next one will probably be December or maybe even January. And we've been teaching these courses since April this year, very successfully. People are dramatically changing the way they work across the board, different industries, different roles and so on. So if you are interested in learning how to do stuff like that, come and join our next cohort. You can find the link in the show notes. So it's a single click away to tell you about the course and how it's running and what it's doing. And you can come and learn how to build these kind of systems yourself.

19:55But now back to Anthropic and this segment. The next thing that they did is a voice profile personalization. So HBDR provides writing samples. Claude learns their individual style. And then every piece of communication is using their personalized style versus a generic AI style. I do the same thing. I do this for more or less any content that I create is learning from other things that I'm doing myself. and it's going to mimic and learn how I communicate and use that. Again, for me, it's very easy. I have hundreds of hours of me speaking to you guys on the podcast, plus posts that I write on LinkedIn, plus a lot of other stuff.

20:33So I have lots and lots of content. But for each individual who is a BDR or in any role, you have your emails that are the way you communicate and it can learn from it and write in your style and the same as you. There is a discovery call scoring, a dedicated skill that evaluates gone calls transcripts against Anthropic Internal Discovery Playbook And it outputs the top three strengths, the top three improvement areas, and one highest leverage recommendation per call. So again, just help salespeople be better and better and better over time. As when I used to run a call center, we used to do this manually.

21:09The disadvantage of doing this manually is that you cannot do this for everybody. And you randomly guess which calls are going to be the interesting ones to review. and you hope to catch interesting stuff that you can share with the people who were running the call as well as other people, this is reviewing every single call for every single individual with every potential client, which obviously drives dramatical improvements for the individuals and the team as a whole. Another component is an ad hoc analytics capability. BDRs now have a trend dashboard, spend analysis, and undiscovered usage opportunities all ready for them to use without having to burden the data team to do this analysis for them.

21:48So again, every company out there has some kind of a data analysis team or platforms and so on, but these require very special people and they always have a very long queue. So if you want somebody to develop a new research for you or a new platform for you or a new dashboard for you in your BI system, you will wait for a while. And now you can build it yourself with AI in seconds and it can provide real value to you immediately, helping you to do your job better, in this case, a sales job. But again, the underlying message here is about context. The way this is working, why this is so successful for Anthropic, is not that they're Anthropic, is the fact that they are giving AI more and more context.

22:28Or like John Albert himself, the same guy we quoted previously, has stated, and I'm quoting, my best advice, start experimenting. The more context and tools you give it, the more you can get done. And I agree 100%. As I've learned to connect the dots through the different systems that I have and create a context layer that is now available to the AI always without me having to attach files or connect it to specific projects and so on, it dramatically improved the way my entire AI system works. So context is the bottom line of this thing. To tell you how powerful this is, per SAS TRAI reporting, 54 % of new enterprise logos at Anthropic now come from self-serve.

23:09Basically, the ability to find opportunities and evolve them and get them to become clients by running automated systems is delivering more than half the new clients for Anthropic right now. And it's not because they're anthropic. It's because they were able to figure out how to harvest their context and connect their tools and processes correctly in order to deliver value to potential customers at scale. On the same topic, something that OpenAI announced this week is a new feature that you can activate that's called Computer History. So what is it? It's an opt-in feature that is on ChatGPT Mac OS desktop app, and it captures interactions, events, clicks, typing, keyboard shortcuts, app switches across basically all the pieces of software and apps and websites that the user select.

23:58So it's not everything, but you can tell it what you want it to monitor or what you want it not to monitor. And it converts this activity into memories and searchable timeline that both ChatUPT and Codex can query when they're doing their future work. Now, this replaces a earlier research preview tool that they called Chronicles, but there's a very big change. Chronicle relied on screenshots. Computer history uses the actual interaction event stream. It actually looks at what you're doing versus what happened on screen, which gives it a lot more, yes, you understand, context to what you're doing, how you're doing it, in what sequence you're doing it, and so on.

24:37And it doesn't have to guess things just by looking at screen. Now, it is off by default to Pro Business and Enterprise licenses. Again, it's currently available only on the Mac OS application. Pro users can opt in individually, and business and enterprise admins must explicitly grant access before members can enable it, which makes a lot more sense. It is not available in different countries, including Switzerland and the UK, because obvious reasons. Now, what it doesn't capture, by the way, is screenshots, screen recording, microphone input, system audio, private mode, web browsing, interactions and stuff like that.

25:09So anything that might be personal and private, it is not going to capture. So they really tailored it to capture your business operations. So AI, in this particular case, ChatGPT's more advanced modes can use it to build and help you build more detailed and more effective automations and AI support for the way you work personally. Now, one of the issues with that system is that how it saves the data is in markdown files, just like most agentic world does. And these markdown files are not encrypted in any way. they're saved locally on your computer. So anybody who gets access to your computer and know which files to look for can learn exactly what you're doing and how you're doing it and how you're doing your processes and so on.

25:51So perfect, it is definitely not, but the direction is clear. You give AI more context, you're going to get better results. And these labs and more and more AI tools are going to be asking you to give it access to the way you work, the actual process you are doing in order to learn from it, in order to help you generate better solutions for the way you specifically work. So what's the benefit? The benefit is that AI on its own will be able to figure out repeatable work that you do regularly. And we all have a lot of repeatable work that we're doing regularly and suggest converting it into reusable skills or automations with multiple skills that can do that work for us instead of us doing it.

26:34So we're going from a world in which we have to identify the use cases. We have to decide which ones are important. We have to figure out how to develop them to a world in which AI is going to look at what we're doing, suggest an automation. And if we say yes, it will just build it for us without having us understand exactly how the whole thing needs to be orchestrated in order for it to work. Another great example of this, and we talked about this last week and in the episode that I released about GrokBot. GrokBot has a mode in which you can tell it. I want you to look at what I'm doing and then create an automation that does it.

27:07You can teach it how to do a specific process literally by demonstrating the process itself. So over there, it's more of proactive. In this particular case from OpenAI, it's running in the background and doing the same thing. But the outcome is the same exact thing. We are helping the big labs or the providers of the AI tools to learn our work so the AI can do it for us. On an individual level, this is absolutely incredible. Again, I've been doing this proactively for a very long time now, investing a lot of time in this. Having this be done in the background is magical and is amazing. If you aggregate that, what does that mean for the world?

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27:44It means that AI will learn more and more tasks and more and more ways to completing those tasks. And we learn what are the best ways to complete those tasks. And we'll get to the point that humans will never be able to do the tasks better than AI. Now, in this particular case, these are four mundane tasks that are repeatable things we do on our computer that probably most humans will not like to do anyway. But that being said, it will get to the point that we'll have to find the things we can actually do. And I'm not sure what that is at this point. The third example that we're going to dive into is from Harvey, which is a legal platform that has been around for a while.

28:19They're extremely successful. They've raised crazy amounts of money. Their revenue is skyrocketing and they've just launched Harvey 2. So the big problem that Harvey 2 is trying to resolve is that every lawyer has to rebuild the context for every time he's working, upload the documents, re-explain the matter, restate the preferences. Harvey too creates spaces that pre-populated with matter context, documents, parties, permissions, ethical walls, all the stuff that it needs, all the stuff the lawyer would need in order to build a case or go through a thing. And it's also looking at the task history, basically Harvey's memory of how an individual lawyer or how a specific firm works.

29:01And it combines these two together to deliver faster, better, more context aware knowledge to the outcome that it's doing. In the product announcement, the Harvey team said, the work carries history and context. Your process carries preferences. Harvey 2 starts with both. Again, even what they're calling process and preference is still context, It is the knowledge to the AI on not the background information, but how to do the actual work, how you do the actual work. So what does this tell us? It tells us, as I mentioned in the beginning, that context is the most important aspect for success in the current AI environment that we are in.

29:41It is not about picking open AI versus Anthropic versus Grok versus Gemini. All these tools are now really good in most tasks. It is about giving the AI the right context in order to understand the task better, in order to understand how you, how your company, how your process, how you individually do the task and learn from that in order to adapt to your working environment and provide you better results, but still aligned with the way you want to work. On one hand, I think this is amazing because it enables companies to accelerate the way they're adopting AI with significantly less friction.

30:17And on the other hand, I think it's missing a much bigger point. Trying to work the way we work today is the easiest from an adoption perspective, right? The AI is not asking you to change the way you work. It is just going to help you in the way you work today. The reality is there might be a significantly more efficient way to do this, which means we will need to give AI more freedom to connect the dots on a much higher level and then help us figure out a better way to do it than the way we're doing it today. I think there are more and more individuals and potentially few companies that are going down that path.

30:52Rethink the way you work. I'm definitely doing this. I'm questioning everything all the time. Does that make my world easy to manage? 100 % not. Does it allow me to do really big breakthroughs every month or two? Yes, 100%. Because I'm not necessarily looking to replicate with AI the things that I'm doing right now. I'm looking at what the goal that I'm trying to achieve, and I'm trying to let AI figure out the best way to do that. But the bottom line is that I want you to take from this segment is that you need to start thinking about context. How do you make the data in your universe accessible to AI in a safe and controlled way?

31:28I'm not saying let every employee in every company connect anything they want to the AI. It's not what I'm saying. That's a catastrophe that is just waiting to happen. What I am saying is you need to find the right ways to give AI access to the relevant pieces of data all the time. So you don't have to figure out what it needs to know when, so it can connect the dots for you and help you make better decisions and drive significantly higher efficiencies from your current resources. And now to rapid fire. As I mentioned in the beginning, we're going to start with some safety and security thing. Greg Brockman expressed serious concern this week that open source models, and he specifically talked about ZZAI's upcoming OpenWay GLM 5.3, which was just released this week, has extremely advanced cyber capability and is likely to, and I'm quoting, significantly accelerate the threat landscape.

32:17What he was talking about is the fact that all the new models, obviously the new Chachupiti Astra that is now being stopped from future development, obviously he is focused on what he knows internally, that is Astra, which is the next model that OpenAI is supposed to release, that they just stopped its training run in order to build better and safer chains to hold it in place and be able to control it. And what he's saying is that while they're doing it, the open source models are not. And based on Greg Brockman and many others, these tools have extreme cyber capabilities that are, and I'm quoting, only a few months behind the frontier.

32:54And it is likely to, and I'm quoting again, significantly accelerate the threat landscape. To explain why this really matters, let's look at Safer AI Cyber Gym Evaluation, what they do is they test AI for different cybersecurity and other risks. When they were trying to test Claude Opus 4.7, the model refused basically every bad thing they were trying to do with it. Literally everything to the point they had to stop the test because it was meaningless because they found no way to allow the model to give them the negative information that they were trying to get. like either that involved cyber as well as the ability to generate different kind of biological or chemical weapons.

33:36On the flip side, GLM 5.2, the previous model from Z.ai, did not refuse any of the offensive cyber attacks that they gave it in the evaluation. So basically every cyber attack request that they give it, it was willing to perform. And it also comes with open weights, meaning it can be better tailored and customized to do these kind of things because it is an open weight model. Now, what does that mean? It means that people with bad intentions will use these models, these open source models to do really bad things. Do I think threat actors will use this? Of course they will, just like any other software they have access to.

34:16Do I think it will be a significant change in the threat landscape? Absolutely not. So he thinks, so what does that It puts us in a world where cybersecurity will become a much, much more complex thing because the AI that will be available to anybody who wants access to it will be there and will allow people to design and perform really significant cybersecurity attacks. And the defenders may not have the same efforts and the same capabilities or at least the same timelines to prepare and block all the issues that they have right now. the issue in the Greg Brockman blog that he wrote, he talks about his own personal blog and how he found in a few minutes, a lot of loopholes, just because there's old technology and things that he connected through the years.

35:02And he's saying it's the same thing with every software or every company out there that has technological debt that makes them exposed that so far was acceptable and becoming unacceptable moving forward. So he's saying every company has just a few months to get its act together and find the loopholes and defend its systems much better. Otherwise, it will be extremely vulnerable to cybersecurity attacks. Staying on the topic of security, but from a completely different angle, OpenAI just launched what they call private safety processing. And the idea is to make sure that companies' data is never exposed to human eyes inside of OpenAI.

35:38So what private safety processing is a new safeguard designed to identify misused patterns across multiple AI interactions without compromising OpenAI's zero data retention commitment for API customers. In my software company, Databreeze, that does invoice vouching at scale using AI, this is a very critical component for us, right? Because we do a lot of AI agents that are running through the process that helps companies go through, analyze, vouch, and reconcile thousands of invoices without human interaction, with humans just approving the step in the end. We obviously use the zero data retention from OpenAI API to make sure that the data from our customers and their customers is not going anywhere.

36:25That being said, in specific more advanced agentic cases, the AI companies want to be able to understand what's happening because it's a much longer horizon, more complex process. As an example, Anthropic has announced that the data that goes into long horizon tasks in Fable 5 is going to be evaluated, which led to almost zero adoption on the enterprise because nobody is willing to take that risk of which data goes where, where it's going to be stored, who's going to be reviewing it, who's going to be seeing it. So this approach by OpenAI, the goal is to still help them understand different patterns in long horizon, big data kind of queries and processes without breaking the promise of zero data retention.

37:07So kudos to OpenAI for this new feature. I assume we'll see the same exact thing from other labs as well. Another, now two new features, capabilities and releases this week that are significant. The first is, I don't know what happened this week, but we have three really significant releases from audio companies all this week. So Pika Labs have dropped four Frontier audio models, soundtrack, music, SFX, and speech. It's priced up to 20 times cheaper than their nearest competitors. It allows to generate long segments of each and every one of these things. So either soundtrack or music or speech and also doing sound effects.

37:47And they're just making really good models at a really cheap entry rate. Another big news from this week when it comes to sound, Whisperflow, which is a company that many, many, many people I know use in order to do voice dictation. I started using them when it started the hype. And then I switched to just internal speech recognition inside of my Mac. I don't think it's as good as Whisperflow. I think Whisperflow is much better, but I think it's good enough for my needs. And so I switched back to a free model that doesn't leave my computer versus a paid model that takes everything that I say to type into every piece of software that I use and send it to a third party.

38:23But anyway, Whisperflow just raised$280 million at a$2 billion valuation. To put things in perspective, nine months ago, their valuation was$700 million, which is$2 billion, meaning it's almost tripled from the beginning of this year to now. They also unveiled Kanto, which is a proprietary speech model, which is engineered specifically for noisy real-world conditions, meaning you can voice type very accurately regardless of the noise around you, which is very helpful if you're like me and you don't type anything anymore and you voice type everything. Another announcement this week came from Cartasia, who shipped Sonic, which is now ranked number one on the Speech Arena leaderboard for both naturalness and speed, with sub-90 milliseconds latency across 40 -plus languages.

39:10And they also added a layer of emotional intelligence in order to make it sound more realistic. And enterprise customers, as part of their release, are reporting 2.9 % conversion lifts and 12.2 % engagement increases just because of the improvement in the models themselves. So big boom on the voice understanding and voice generation side of the world. Staying on the topic of what AI can do these days, Asana, just according to a promotional segment from OpenAI, Asana used OpenAI Codex to remove an outdated testing system called Enzyme in two calendar weeks, a work that was originally estimated to take five years and cost about$6 million.

39:54dollars. The project cost them$12 ,000 running AI models. And this is obviously a very, very significant improvement over the assessment of humans doing the work. One of the things that I talk to leaders of companies right now is that you have to reconsider the ROI of projects or initiatives that you thought, or maybe even didn't think of running because things that were cost prohibitive or the ROI just wasn't there or the risk in the ROI just wasn't there is now there because you can now do things that were impossible to do before or would have cost you crazy amounts of money and hence you didn't even consider them and now you can do that.

40:32This applies from things like this, like removing old system and replacing them with new one, or with potentially completely changing your business model because the way you deliver things can change and it couldn't change before. So this is just food for thought. Another thing that was announced this week comes from Slack. Slack just introduced Slack code. It It is a new feature that brings agentic software development out of the private browser tabs and into dedicated team channels where humans and AI agents collaborate transparently. So how does it work? Basically, in those code channels, Slack code introduces project-based code channels that automatically spins up when a team tags a coding agent, and then the coding agent will actually go through the conversation.

41:14It will go through different code diffs, and it will build whatever it needs to build as part of the conversation with the people in that channel. The idea is taking vibe coding the way we already know it and love it and making it a much more team effort where multiple people can participate in the process. I think this is really smart. And I know that because of the huge distribution Slack has, this is going to be very interesting to see. What I don't know is how the companies will control and manage and deploy and support the code that is generated through this mechanism. them, but I'm sure the infrastructure for that will be developed over time as well.

41:50Now, connecting one more point to the way we started the conversation today with the healthcare side of thing or the research side of thing, Anthropic just published a research this week that has demonstrated breakthrough capabilities in accelerating drug discovery by designing ProteinBinder with 93 % success rate. Basically, 14 out of 15 actually work correctly. They also achieved heat rate of 22 to 35 % compared to industry standards of 10 to 15%. Now, the AI also analyzed complex chemistry data in under 25 minutes, a task that typically takes chemists hours or days to complete. Now, what does this mean?

42:29I'm not a chemist. I don't know the exact understanding of what it means. But what it means is it means that AI can now do really advanced, really complex chemical analysis and chemical design in a way that beats humans by a very big spread, both in means of time and in means of quality of work and success rates. Going from healthcare to another topic where AI is changing the way we engage with the world, a new RTB House survey of over 1 ,800 consumers across US, UK, Japan, and France revealed that shoppers are increasingly trusting AI tools to assist with purchasing decisions. 42 % of US millennials are willing to let AI agents buy items up to if returns are guaranteed within seven days.

43:13However, over a third of all consumers still want human review, basically your approval before AI completes the transactions. That sounds really low to me. Only a third of people will to verify whatever the AI is buying. I'm not sure about that, but I definitely can see how more and more people are trusting AI with helping them find the right output. Now, what makes it really interesting is that AI currently ranks more trustworthy than influencers, newspapers, major media outlets, and social platforms like TikTok and Instagram, with 44 % of consumers trusting AI compared to much lower levels on these other platforms.

43:48The only thing that ranks higher than that is friends and family, which rank at 50. So that's getting close to that as well. Now, another interesting thing that has been released this week that is supposed to dramatically boosts productivity of all the users is replit made a big announcement on august 18 and they introduced what they're calling free mode now the name is really confusing because it is not actually free it is under the 20 a month plan but it lets subscribers create 30 times more code for the 20 that you're using how are they achieving that they're achieving that by integrating chat GPT 5.6 Luna and integrating it into everything they know inside of Replit.

44:305.6 Luna, OpenAI's ways to try to compete with the really low prices of Chinese models. So it is a very capable model at a very cheap price. And by integrating it into Replit, they're now able to perform these tasks again at a 30x higher efficiency than they were able to do before. So huge impacts across the board from shoppers, consumers, science, basically any aspect you can think of. AI is making really big waves even just this week, which leads to crazy, stupid amounts of money that is being poured into anything that has to do with AI infrastructure or any significant thing. So I'm going to throw a few numbers at you.

45:12All of them are from the last two weeks. Most of them or from this past week to tell you how crazy the financial investment is right now when it comes to building AI capabilities. The first one comes from NVIDIA. NVIDIA has partnered with six Wall Street largest financial institutions to establish financing platform and to deliver over 500 billion dollars in third-party capital to develop AI infrastructure. If this doesn't sound like circular financing. I don't know what is, but the idea is that these companies will push money to third-party companies who want to buy NVIDIA compute in order to deliver AI capabilities.

45:55Again, this is half a trillion dollars of investment committed to building AI infrastructure to drive more money to NVIDIA. Staying on the really crazy numbers, Stripe just agreed to acquire OpenRouter for$7 billion. We reported this a few weeks ago, so it's not news, but the news, it's a final deal, and Stripe will do that. The acquisition is going to pay OpenRouter 5.4 times increase over their Series B valuation of$1.3 billion. That was in May of this year. Reminding everybody the big deal, OpenRouter was one of the first companies to provide a router. Basically, you connect to one API and you can get access to more or less any AI API on the planet.

46:38just by in your one API calling for whatever model you want. I've been using it for a very long time, both in my software company as well as in different things I'm experimenting with. But they are now processing over 10 trillion tokens every single day across all the different models. And Stripe that wants to be the company through which you pay for all of that makes a very interesting investment that I have a feeling will pay off big time. Staying on the high rollers circuit, Databricks raised$5 billion at$190 billion valuation. How did this crazy number actually happen? It seems like a premature press report triggered unexpected investor demand that forced the company to raise far more money than its initial$1 billion that it wanted to raise.

47:21So again, the target was$1 billion, they raised$5 billion instead, 5x from investors on a very short amount of time, which gets the Databricks overall investments to 20 over the past 20 months. This is an average of a billion dollar a month of capital that's being raised. Again, nothing like this ever happened in history. Another company that made a big splash this week is Higgsfield. Higgsfield is a company that aggregates many video and image generation tools to one unified environment that enables creators to create anything they want in the visual space. They just raised$400 million Series B at a$5.4 billion valuation.

48:02Their revenue have grown insanely in the past few months. When I say grown insanely, their revenue increased from approximately$20 million a year ago to$700 million. Right now, a 35x jump. They're serving 30 million users across 238 countries and territories with the US obviously being the largest market. So huge raise, huge financial success. At least the two are tied together. Another huge raise comes from Etched. Etched is a company that builds and develops AI inference hardware. They've secured a$700 million funding round, valuing them at$21 billion. Now, why I think this is an insane, crazy valuation?

48:45Because they just delivered their hardware to their very first client. So quantitative training company Jane Street received Edge's first AI inference track last month. So this is a company that has one live client that just rate 700 million users at a 21 billion dollar valuation. Another interesting round this week comes from River, which is a new company that was founded by XAI co-founder Igba Bushkin, who just raised 1.1 billion seed slash series A round. So again, a company that has nothing other than the right name or names, I guess, in the founding members, has raised over $1 billion as a seed round from really, really large name.

49:36Their goal is to build an entire ecosystem, including training models, product layer, and the hardware to enable personal agents that users can train themselves rather than be relying on a third-party environment. Another big name that we all know is Lovable. So Lovable, one of the most known and most loved, pun intended, vibe coding tools, just raised four out of 13.3 billion. But again, in this particular case, it actually makes some sense. The company hit 500 million in annualized run rate revenue in June of this year, showing big growth in both adoption and stickiness of users to the platform.

50:13So at least there is real revenue and real revenue growth and customer base behind this valuation. So before I give you two final and really interesting anecdotes that happened this week, there is a lot more news to report this week, but I can't report it all. Everything else, all the other really interesting and important articles you can find in our newsletter. You can sign up for the newsletter with a couple of clicks from a link in our show notes. So open your phone right now. And by the way, when you open the phone, I would appreciate if you also Also share this podcast with other people who can benefit from it.

50:44I'm sure you know people who can benefit from it. And it takes 10 seconds from your time to click the share button and then send them the link so they become aware of this podcast. You can send it through whichever emails, social media, WhatsApp or whatever other messaging tool that you're using. Just share it with people who can benefit from it. I will be really grateful. They would appreciate it because they're going to learn something new and you're going to be doing the right thing for letting more people understand what the hell is happening in the AI world right now. But now the last two interesting, weird things that happened this week.

51:12The first one is an AI agent named Luna that is running on Claude and a little bit of open AI infrastructure has recommended to terminate a human employee who is late 17 out of 23 shifts. So a company called Andon Labs has gave Claude a$100 ,000 budget, a corporate credit card and a three-year lease on a building to see what is going to happen when you let AI run a retail store. So far, what happened is that the store is losing money. Again, we're still early in the experiment, but so far the store is losing money and it just fired its first employee. This is most likely the first human employee in history to get fired by an AI manager.

51:54That being said, that person was late, 17 out of 23 shifts. Now, is that okay? Not okay. I'm not 100 % sure. But what it did immediately is that it drove to a new legislation in California called SB 947, which was introduced just days after this event happened, with that is stating that AI cannot fire or be involved in significant HR changes without human supervision. Where do I think this is going? I'm not sure, but I definitely will see more of that in the future, where AI is involved, maybe not making, but involved in critical hiring or termination decisions for individuals in companies. Some companies may decide to do this without human supervision.

52:38Some states or countries may decide whether that's legal or not. But I would not be surprised if this becomes a core component of how decisions are made, not because of this particular incident of 17 shifts that are being late, but just because of AI's ability to look on a much broader set of parameters and recommend things that are based on actual data versus gut feeling of managers. So I do think there's good aspects to this potentially as well. Again, not sure about this particular incident and what I feel about it. And the last weird news of the week comes from a sorority rush event in Alabama.

53:16Olivia Moore created an AI-generated TikTok influencer named Jenny that infiltrated Alabama's viral sorority rush event, accumulating 1 ,300 followers and nearly a million views that led to brand deals and press coverage in one week before being identified as AI-generated. Now, Olivia is claiming that she did this as an experiment and that the experiment demonstrated how quickly AI-generated content can achieve authentic engagement and raise questions about disclosure, creator intent, and whether reality of content's origin ultimately matters to the audience. This is on the wake of more and more companies that are adding different ways in the backend for us to identify AI-generated content.

54:04We talked about last week how Anthropic are adding now a way for them to know when content was generated with their systems. We talked about SynthID many times in the past from Gemini. We talked about OpenAI, just recently joining the international standard for that. So there is a real, real need in the world to know what is AI-generated and what is not in order to protect us from exactly these kind of things at a much, much, much larger scale. We're going into election season right now in the US. A lot is at stake and I have zero doubt that these technologies are playing a role already. And I would like to minimize that to the smallest amount possible.

54:44I don't think we can reduce it to zero. That's it for this week. Come and join us back on Tuesday. We have a really cool episode coming up that's going to show you how anybody with zero technical skills can build their own applications and share it with people they like, or even share it on the App Store. Again, with zero technical skills. So if you want to get inspired on how you can generate applications that can make yours and other people's lives better, more interesting, more productive, come and join us on Tuesday. Check out the multi-agent orchestration course against the next cohort that's open is in November.

55:15And so you can check that out in the link in the show notes as well. And that's it for today. Have an amazing rest of your weekend.

From the publisher

What happens when AI stops being impressive in demos—and starts helping us fight cancer, transform how companies operate, and attract hundreds of billions of dollars in investment?

That shift may already be underway. This week brought some of the strongest signals yet that AI’s impact is moving beyond better chatbots. From personalized cancer treatments and dramatically earlier detection to autonomous business workflows and AI-powered scientific research, the conversation is increasingly about measurable outcomes.

For business leaders, there’s an equally important takeaway: the competitive advantage may no longer come from choosing the “best” AI model. It may come from giving AI the right context about your business.

Anthropic’s own sales team provides a striking example. By connecting Claude to systems including Salesforce, Apollo, Common Room, and Gong, the company reports cutting manual work by 70%. The lesson is simple: smarter models help, but AI becomes dramatically more useful when it understands your data, workflows, processes, and preferences.

And that’s only the beginning.

In this session, you'll discover:

  • Why new developments in personalized mRNA cancer treatment could represent an important milestone for AI-assisted healthcare.
  • How AI is helping researchers detect and understand cancer earlier and with greater precision.
  • How Anthropic is using AI workflows to reduce manual sales work by 70%.
  • How AI systems are beginning to learn the way people work and turn repetitive activities into automations.
  • How increasingly capable open models could dramatically change the cybersecurity threat landscape.
  • How AI is accelerating drug discovery and complex scientific analysis.
  • How AI-assisted coding and agentic development continue to change software creation.
  • Why an extraordinary amount of capital is flowing into AI infrastructure and applications—including a proposed $500B financing platform around NVIDIA infrastructure, Databricks' $5B raise, and major funding rounds across the ecosystem.

About Leveraging AI

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