1. Podcasts
  2. Nature Podcast
  3. Feeling the heat: fossil-fuel producers linked to dozens of heatwaves
Nature Podcast

10 Sep 2025 · 37m · 8 chapters

Episode artwork

Feeling the heat: fossil-fuel producers linked to dozens of heatwaves

In short

The episode covers two main Nature news stories plus research highlights. First, a Nature study links fossil-fuel “carbon majors” to heatwaves: it attributes climate-change-driven increases in intensity and probability across 213 heatwaves (2000–2023) by allocating responsibility to major producers accounting for about 57% of global emissions. Key claims include that, for some companies, emissions made heatwaves up to ~10,000 times more likely (median), and nearly a quarter of heatwaves can be attributed to a single company’s emissions (median). Example: ExxonMobil’s 2021 Pacific Northwest heatwave—median estimate over 10,000x more likely; lower bound still ~19% higher probability.

Guests

Jeff Tollefson (Nature climate reporter interviewed by Nick Petrich-Howe). Second story: US researchers’ pushback against Trump-era science funding cuts via lawsuits and public outreach; guest speakers are Heidi Ledford and Max Kozlov (authors of a Nature feature). Also discussed: Nikki Maphis (early-career researcher suing NIH/Trump for terminating grants).

Written by AI. May contain mistakes.

Chapters

0:45

Attributing Heatwaves to Fossil Fuel Producers

A discussion on a study linking fossil fuel emissions to heatwave intensity and frequency.

“First up this week, a study in nature has attempted to identify who is responsible for the intensity and frequency of heatwaves.”
10:33

Upcoming Discussion on US Scientists' Response

Preview of the next segment about scientists responding to administration policies.

“To read Jeff's story, look out for a link in the show notes.”
10:44

Research Highlights: Ancient Irrigation and Modern Technology

Highlights of recent research on ancient civilizations and innovative glasses technology.

“Shifting tides along the coast of ancient Mesopotamia might have spurred the rise of the world's oldest civilization.”
14:01

The Impact of Grant Terminations on Researchers

Learn about the challenges faced by researchers due to sudden grant terminations and legal actions taken.

“And so I think everybody's thinking about how they can continue their research given the difficult situation for universities.”
19:31

Grassroots Efforts to Change Perceptions of Science

Discover grassroots initiatives aimed at improving public understanding of scientific research.

“I just want it to go back to how it was, because it was working.”
24:11

Advancements in Type 1 Diabetes Research

Explore recent breakthroughs in treating type 1 diabetes using genetically modified cells.

“You could hear it a lot, for example, in a hearing before Congress when the U.S.”
28:00

Breakthrough in Type 1 Diabetes Treatment

Learn about new research on genetically modified pancreatic cells for diabetes.

“Yep and it's the pancreas cells that stop functioning in type 1 diabetes and And that is what this paper and a lot of sort of recent research are focusing on.”
32:50

Exploring Colour Perception in the Brain

Discover the relationship between brain activity and colour perception.

“been reading in Nature based on a Journal of Neuroscience paper, and it's about colour perception in the brain?”
A man walking through an airport, asking his phone a question

Ask about this episode

Get the gist, explore an idea or ask about something said.

Claude

On Nature Podcast, what are the key points of this episode?

Searching your listening

Transcript

Automatic transcript. May contain errors.

0:23Welcome back to the Nature Podcast. This week, a study assesses who's responsible for heatwaves. And the scientists fighting back against US funding cuts. I'm Sharmini Bundel. And I'm Benjamin Thompson.

0:45First up this week, a study in nature has attempted to identify who is responsible for the intensity and frequency of heatwaves. Reporter Nick Petrich-Howe spoke to Nature's climate reporter, Jeff Tollefson, about the story. Here's Nick. So there's this new study in Nature that is essentially looking at how to attribute responsibility for heat waves. Can you lay out for me, Jeff, what exactly they were doing here? So for a long time, more than two decades really, climate scientists have been kind of developing the research that would allow them to kind of allocate the responsibility for a lot of extreme weather events to climate change itself.

1:30And say, you know, climate change contributed X to this storm or to this drought or to this heat wave. This study goes one step further and says we can actually draw a causal link between the emissions that come from the fossil fuels produced by various big energy companies and state-owned companies that they call the energy majors. And they say we can draw a causal link between those emissions and any given heat wave. And, you know, in this paper, they refer to them as carbon majors. But these are people like Exxon, BP, Gazprom, that sort of thing? Yeah, they've got all of the big oil and gas companies that you might think of, but they've also kind of broken out other state-owned entities.

2:18So you've got Saudi Aramco, which is a Saudi Arabian oil producer. You've also got kind of a generic coal from China and from India. So there are multiple categories of kind of entities, but together they all kind of make up these carbon majors that are basically the world's leading fossil fuel producers. And so they've looked at these fossil fuel producers and then they've looked at heat waves to try and link the two. What exactly did they find by doing this? Well, it's a multiple step procedure. I mean, first they looked at the contribution of climate change to some 213 heat waves from 2000 to 2023.

2:59These are kind of the big recorded heat waves and they kind of allocated blame to climate change first. And then the second step was to divide up that blame among the various carbon majors, which together account for something like 57 % of global emissions. So in the end, if you look at the blame, you see that collectively these companies all contributed to increased intensity of the heat waves and to increased probability of the heat waves. And then the last step was to look at the individual companies. And so, for example, you could take a company like ExxonMobil. They are able to say, you know, ExxonMobil contributed this number of degrees to this heat wave, which happened in 2021 in the Pacific Northwest.

3:50And they made it more than 10 ,000 times more likely, you know. So that's the kind of their median estimate. I guess the science is pretty robust on linking climate change to things like heat waves. But how did they manage to link it to specific entities? Well, you know, there are some fancy statistics here. And, you know, in some ways, I mean, the simplest way to think about it is they're using established science to link a given heat wave to, you know, greenhouse gas emissions and human induced global warming. And then from there, you know, you can kind of just divide out the responsibilities.

4:30So these companies are responsible for 57 % of global emissions. So that allows you to kind of parse out the collective impact. And then you go down through the list and you just look at the percentage of emissions and allocate the impacts by company. It's more complex than that, but that's the basic idea. And what size of impacts are we talking about here? Well, they're pretty substantial. On average, if you look at the cumulative impact of the emissions from these carbon majors on heat waves, you get something like a 1.7 degree increase in the intensity of heat waves from 2010 to 2019 over the course of that decade.

5:13So, you know, that's a substantial increase just in terms of the intensity of these heat waves. And then on the probability side, you've got even more eye-popping numbers. Like I said, a lot of these companies, you can take their emissions and you can basically say that any given company enabled one of these heat waves. What they found on that front is that nearly a quarter of the heat waves can be attributed to the individual emissions of a single company. So what that means is basically any one of these companies enabled many of these heat waves to occur. That's the median estimate. There are a lot of uncertainties.

5:58And if you go with the 95 % certainty bar and then you look at the lower bound, in many cases, those numbers will be much smaller. In the case of the 2021 heat wave, for instance, they estimated that the minimum bound for for ExxonMobil is that they contributed to a 19 % increase in the probability of that heat wave. And overall, there was a sevenfold increase in the probability of that heat wave. But that's considered kind of a minimum bar. On average, if you look at the median estimate, we're talking about numbers that are in excess of 10 ,000 times more likely for any given company for many of these heat waves.

6:36And so what does this mean for, I guess, everyone on the planet who's being affected by heat waves. I know one thing we've seen in recent years is legal action about climate change and how climate change is affecting people. Is this something that could be used in such cases? Absolutely it can be and I'm certain that it will be. You know this will be part of a larger body of evidence that will factor into various lawsuits that are aiming to hold fossil fuel producers accountable for the emissions from the products that they sell. So there's kind of little doubt about that. The legal experts that I spoke to also say that, you know, science is just one factor.

7:15There are a lot of questions that come up, you know, should you hold fossil fuel producers accountable at all for the products that they sell when they are abiding by national laws and often subsidized by national governments? So it's a legitimate question and it depends on how you think about it. a lot of these lawsuits are basically following the pattern that was set by the lawsuits against tobacco companies. So they're basically alleging that one reason you can hold fossil fuel producers accountable is because they knew of this problem before the general public, and they tried to block climate policies that would have prevented fossil fuel emissions.

7:55And in some cases, they tried to undermine the actual climate science. So this is an argument that's out there. We'll have to see how that plays out in courts, but that is one way that this could play out. One other thing to think about is that this framework can also be applied to many other questions. You could just as easily apply this framework to individual nations and figure out how much any given nation contributed to a given heat wave or any given industry, whether it's the automobile industry or the power industry. And of course, then there are other types of climate impacts that are not covered here and i guess a question i have as well is can we really tie the blame to these companies these carbon majors specifically because i guess they're producing these fossil fuels but all of us are using them in our cars if they're heating our homes etc so you know there is an element of blame to all of us i guess oh absolutely and you know that's one reason why you can use the same framework to divvy up the pie in different ways.

8:59The answer that you get depends on the question that you ask. So this is a framework that you can use to kind of attribute blame in various ways. Like I said, you could look at nations, you could look at industries. In the case of this industry, it is a particular situation where there are a lot of allegations that the fossil fuel industries, you know, actively tried to block action on climate change and undermine science. That's the logic that's being raised in some of these lawsuits and has been raised by some of the people that we spoke to. And so what do you think will happen now? Well, it's hard to say.

9:33The climate lawsuits have been going on for a long time. And as yet, I don't know if they've had a lot of specific influences on national policies. But, you know, they are moving along. There have been rulings. This could contribute to more specific rulings for damages. But I think, you know, the main thing for us perhaps is that the science is going to continue to evolve. What we're learning is that questions that we didn't think that we could answer two decades ago, we now can answer. There was a time when climate scientists would say, well, I can't tell you what caused this specific storm, but I can tell you that it's consistent with theory that you would have more such storms, more powerful storms.

10:14Well, now, 20 years later, we're actually beginning to allocate blame for specific climate events and for specific damages. And I would imagine that that is only going to continue as the science improves. Jeff, thank you so much for joining me. Thank you. Jeff Tollefson there, talking with Nick. To read Jeff's story, look out for a link in the show notes. Coming up in the show, the ways that US researchers are taking on the Trump administration. Right now, it's time for the Research Highlights with Dan Fox.

10:50Shifting tides along the coast of ancient Mesopotamia might have spurred the rise of the world's oldest civilization. Urban settlements first appeared on the Mesopotamian plain more than 5 ,000 years ago. Now, archaeologists may understand how large-scale irrigation could have helped this complex society to develop. Researchers studied a sediment core drilled at the site of the ancient city of Lagash, now in modern-day Iraq. This helped them to compile a history of how the Tigris and Euphrates rivers meandered across the plain and deposited sediment. Changes in the sediment build-up could have altered tidal patterns along the coast, in turn affecting how much water was available through the year for farming.

11:37The team suggests that people joined together to build tidal and then river irrigation systems, and that these collaborations gave rise to urbanised clusters. Read that research in full in PLOS One. Researchers have devised a way to electronically switch the strength of a pair of glasses, a development that could catch the eye of bifocal wearers. Scientists used liquid crystals to produce lenses which can zoom in or out in response to an electric field generated by battery-powered electronics in the frames. With a gentle touch to the right temple or arm of the glasses, users can retune their vision to focus on objects near or far.

12:22The authors say the new technology has potential for mass production and might be especially useful for virtual reality headsets. Take a closer look at that research in Physical Review Applied.

12:39This week, Nature has a feature article looking at how scientists are pushing back against efforts to reshape or, in some cases, constrain the research enterprise in the US, which has been initiated by President Donald Trump. Two of the feature's authors are Nature's Heidi Ledford and Max Koslov, who join me now. Heidi and Max, thank you so much for being here. Thanks for having me. Thanks for having me, Ben. So before we get to the responses, then, why don't you give us a sense of what these scientists are responding to? I would say since the beginning of the Trump administration, there's been a lot of uncertainty about what the future of science is in the United States.

13:17It's been a pretty difficult time for quite a few scientists, whether they've been directly affected by their grants being cancelled or losing their jobs if they work for federal agencies. and a lot of concern that the public just isn't aware of what's been happening, how important science is first, and second of all, the threats to it that researchers are facing now. I think there's been kind of a systematic, a whole-scale dismantling of the U.S. scientific enterprise that has led to so much uncertainty and things broken left and right. And so I think academics all over the country are rethinking what their place is in the research community, in the scientific community, with all of this in mind.

14:00Many, we've reported, are considering leaving the country. And so I think everybody's thinking about how they can continue their research given the difficult situation for universities. And yes, you've been speaking to a bunch of these different folk then about efforts they're engaging with to try and undo or rescind these decisions we're going to talk about a few of them today and in the first one you spoke with nikki mafis now in your story you talk about how she had a grant application essentially binned with no warning at all now we've got a little bit of audio from your interview with her it's a slightly wobbly phone line but she's talking about why grant and training funds for early career researchers are so important here she is it like impacts your career trajectory it sets you up for success it kind of lays out this flight plan in order to set you up your own lab and for me and the hundreds maybe thousands of researchers across this country that are in the stage that i'm in like later stage postdocs trying to launch an independent research career we have just been completely stymied and stopped and there's nothing we can do about it except for what i'm currently doing about it which happens to be this lawsuit yeah so she as she describes is taking part in a legal action then, because the courtroom is where a lot of these responses are taking place.

15:22Yeah, so she is one of a handful of researchers and organizations representing researchers that sued the Trump administration for essentially binning applications for terminating grants on a whole slew of topics from DEI to COVID-19 to climate change. these are projects that they're in some cases years into and have already spent thousands or even in some cases millions of dollars and so nikki is in a really precarious situation because she is coming to the end of her postdoc and like so many others she has to make the difficult step of starting her own lab and there are specific grants that the nih the national institutes of Health puts out to help researchers with that transition.

16:14And she being a woman and from a low income family, she applied for one that's geared toward underrepresented minorities in science. And then all of a sudden, her funding opportunity disappeared. And a staff member at NIH said, I'm so sorry, but your application has been pulled. And she told me that she'd never cried more as a scientist than in the last six months. And this is then where the lawsuit comes in. Yeah, so MAPHIS and a whole slew of other researchers have joined this lawsuit and others, alleging that the Trump administration has essentially terminated these grants without any kind of cause, and that the policies put in place are totally arbitrary.

16:57You know, for example, their whole crusade against any kind of DEI research. I mean, there's no definition of what DEI research even is. And so that means that they have been able to cut essentially whatever they want to that fits under that umbrella, the researchers allege in the lawsuit. And it came to a head in June when a federal judge who was appointed by a Republican and who's been on the bench for more than 40 years, he not only ruled in the researchers favor, but he said this is the worst racial discrimination I've seen in my 40 years on the bench. And the researchers, they didn't raise any kind of racial discrimination portion in their lawsuit.

17:44But it's clear that in targeting, quote unquote, DEI research, in targeting research that benefits LGBTQ folks in the country, that is what the Trump administration has done. And so I think a lot of researchers were really encouraged to hear a judge and a judge appointed by a Republican, say it so clearly. I'm sure though the Trump administration doesn't think this. What have they said? Yeah, basically the Trump administration has doubled down on its stance and has said that it stands by its decision to end funding for research that quote-unquote prioritized ideological agendas. And so in some cases, the Max Grants have been reinstated.

18:23Not all of them, it must be said. Is this the only attempt like this to go through the courts? No, there's a whole slew of efforts. There's a group of University of California researchers that have also sued to get their grants back specifically in the University of California system. And I think what's special there is it's really just the researchers who are leading that effort. I will say some of these cases have yielded some success. However, I think the bottom line here is even if the grants are reinstated, the damage has already been done in that their funding was put on hold for several months.

18:59And in some cases, even if their grants are reinstated, they still don't have access to their money. So it's to say that these efforts are important and they give these researchers absolutely an important sense of purpose. But even if a judgment is ruled in their favor, it could still get tied up in appeals as the case with MAPHIS has. It has gone all the way up to the Supreme Court. And even if the grant funds are reinstated, it's a long journey to still restart that research. It's not as easy as just turning the lights back on again. Well, let's hear once more from Nikki Maphis then, and the outcomes she'd like to see.

19:34I just want this to stop. I just want it to go back to how it was, because it was working. We were doing research that mattered. Research touches every aspect of the community. And it's incredibly important within each community in which these universities are located, from the biggest cities to the smallest towns. They're economic drivers. They provide jobs. And it's been really exciting because I've been able to see how the first phase was so hopeful and exciting and successful. And I've known people who they got their grand back. And if being in the slosses means that happens, great. You can absolutely hear the passion in her voice then, say, putting herself up as she has.

20:22But there are other efforts going on, too, as well. One thing researchers, as we know, are very, very good at is gathering data. But maybe one of the things that being done here isn't gathering, but rescuing, perhaps, is an apt phrase, data as well. We spoke about efforts on this a while back, Max, and how this was kind of something that researchers were looking to do, but really they have picked up the ball and run with it. Oh, they've done that and more. You know, it started as really a Google spreadsheet of a list of all the grants that have been terminated by agencies like the National Institutes of Health and the National Science Foundation.

20:57And then since then, they've launched an entire website, they've made their data easily searchable. It's gone so far as the judge in Nicole Maphis's case, he cited them as basically a physician's desk reference of grant terminations. And their role is just so important because the health department has put out its own list of terminated grants. But, you know, this is coming directly from the government and journalists and scientists were immediately skeptical of this list. And so what their work does is really verify that that list is accurate and then fill in the gaps. And it makes it much more searchable and workable to find trends in the data.

21:42We did our own investigation at Nature a few months ago, and we found that essentially more than half of all the research done about LGBTQ plus folks has been terminated in just the span of two months. And so it allows journalists, scientists to do this kind of important work that would otherwise be missing because we just wouldn't have the data for it. And of course, there's another side to this as well. It's not necessarily all through courtrooms and the internet that this is being done. Heidi, you've been looking at, dare I say, a more grassroots approach as part of efforts to try and help maybe shift perceptions of scientists and science in general in the face of growing apathy and worse.

22:28Yeah, that's right. So I spoke to three organizations, really, that are mainly, I'd say, trying to remind the public or even just introduce the public to what scientists do and why it's important. And there was one common thread among all three of the groups that I spoke to, which was that over the past few years, especially since COVID, all three of them had noticed the discussions online or when they go back to their hometowns, especially if they're from rural areas, that they would hear strange things. You know, these suggestions that scientists, when they get a grant, that all that money goes into their pocket somehow, which is obviously not true.

23:01Or they would hear the kind of misinformation that sprung up around COVID vaccines and is potentially being spread to encompass other vaccines as well. So two of the groups have been on letter writing campaigns to hometown newspapers in particular. One of them is called Science Homecoming. Another one was called the McClintock Letters. And both of them are trying to get scientists to write letters to the editor, basically, or opinion pieces. You know, scientists tend to cluster around more urban areas. Many of them come from the more rural areas, though, within the US, and they don't necessarily go back home and talk about what they do that often.

23:38So it's nice, I think, to have a way to reach out to more remote populations that don't hear that much necessarily about what scientists do. So local papers, then, this is not just letters to the New York Times, for example. That's right. And what sort of things are these letters saying? Or what message are they trying to get across? So some of them write about their own personal journey from, you know, maybe growing up on a farm in rural Kansas to studying plant pathology because they were inspired by their background as a child. Others will write about, particularly about medical research, I think, and the importance of what they're studying for developing new therapies for disease.

24:13Another approach also is to just point out the economic benefit of funding for science and how for every dollar that the NIH invests in scientific research, that this then gets magnified in terms of economic impact for the area in which that money was invested. So just to try to bring home, I guess, both the importance of the work that they're doing, I guess also to some extent the character of the people who are doing it in a way, because there is this perception that's being spread online. You could hear it a lot, for example, in a hearing before Congress when the U.S. Health Secretary talked about how scientists are in the pocket of pharma and the folks who were organizing these campaigns wanted to do something to counteract that.

24:51And what sort of a response have they got? What have folk told you about this endeavor? So they have managed to publish quite a few letters in the hundreds at this point, and some of them did get some feedback and some positive feedback. Now, I did also, though, speak to a social scientist about the sort of effectiveness of this kind of approach. And she did say that the idea of targeting a hometown newspaper is quite appealing because that is something that academics might not immediately think of right away, but it is a good way to go to where the people are, meet them where they are, rather than expecting them to log into the New York Times or the BBC.

25:23But she also said there's a limit to what you can do by just asking people to listen to you all the time and that sometimes you need to show. Right. Like we always have this saying in journalism, you need to show, not tell. And she said what universities really need to work on is making themselves a more integrated and important and valued member of their local communities. And that that maybe has fallen by the wayside a bit. And that might take a longer term investment. But that ultimately is maybe what they're going to need to do in order to counteract this narrative that's been emerging. of them as elitists or out of touch.

25:55But the other thing is, I don't want to dismiss the importance of these kinds of activities either. I mean, it's sort of like when people gather together to have a protest that may not necessarily change that many minds. People who are skeptical of whether or not, you know, this scientific funding was a useful exercise of taxpayer money may not be convinced when you have a big rally and carry lots of amusing signs. But it does help to bring people together into a community so that they can then engage in additional activities going forward. Similarly, with these letters, they're not the end game, but they are potentially a useful step along the way.

26:27And how are these researchers feeling about their chances of success, what they would consider success, I suppose, reintroducing grants or undoing cuts, this sort of thing? I think it's harder maybe to measure success from an indirect action like this. And it is maybe a piece in a longer term strategy. And some of these organizations are planning to move on to other kinds of activities in the future. But I do think one thing that was really tough in the beginning was so many scientists just felt like nobody knew or cared, in part because there's so much noise in general, so many changes happening all at once that this just becomes one story among 20 that come out in a day, right?

27:03But also because they sort of realized, I don't know that the public necessarily knows what I do. And therefore, who's going to champion for this? And so I do think it is an important step to try to make sure the public does understand what scientists do and why science is important, but also, honestly, for some of those scientists to feel heard and to feel seen as well. Heidi Ledford there. You also heard from Max Kozlov. To read their feature, look out for a link in the show notes. And finally on the show, it is time for the briefing chat where we discuss a couple of stories that have been featured in the Nature Briefing, which is Nature's daily email roundup of the latest science news.

27:40So I'm going to plunge in with my story first. And it's a really interesting article that I was reading in Nature from a paper in the New England Journal of Medicine and it's all about various attempts and some new success with treating type 1 diabetes with genetically modified cells. Okay so type 1 diabetes then an autoimmune lifelong condition relating of course to the pancreas. Yep and it's the pancreas cells that stop functioning in type 1 diabetes and And that is what this paper and a lot of sort of recent research are focusing on. And it is about trying to get new cells into the body, essentially, that do work, that will produce the insulin that the body needs to control the blood sugar, which is, of course, a problem.

28:25If you have type 1 diabetes, you might be needing to take replacement insulin from injections or an insulin pump in order to manage blood sugar levels. So the ideal that various companies and researchers are looking for is a way to avoid having to have to do all this monitoring and have this dependence on sort of external insulin potentially. You want to be able to have a treatment that allows their own bodies to continually produce insulin as the pancreas normally would. And this is a really interesting breakthrough where they have implanted pancreatic cells from a deceased organ donor. But the key thing, and this is what they were really going for here, is they've genetically modified the cells so that they don't trigger the recipient's immune system.

29:15So they sort of evade detection, which means that the person who has received these wouldn't need to take immunosuppressant drugs. right which is of course a big problem with transplants if you're looking to use say animal organs which is something that i think has been looked at as well that is another problem there right the immune system gets turned on and will attack the implant but in this case that's trying to do away with all that yeah because immunosuppressant drugs there's risk of infection there's risk of cancer there's all these sort of side effects and a lot of the ways that people have been looking at it so far do require some sort of immunosuppressing in order to work.

29:51For example, there's been work going on with getting stem cells to then turn into pancreatic cells in the body. And there was some recent results that sort of showed quite a lot of promise in that in treating type 1 diabetes, but there's still a sort of immune issue there. Another one is using the person's own fat tissue to make, again, stem cells, which can then be reprogrammed into these pancreatic cells. That seemed to go quite well as well, but you have to take these anti-rejection drugs. So this approach then is looking to avoid some of those issues and how have they gone about doing it specifically?

30:27Well we've got some CRISPR gene editing and there's really specific genes that they've gone in to try and tweak seemingly successfully. So there are some genes that usually would be flagging foreign invaders to the T cells in the immune system. And then there's also there's a protein called CD47, which is really important to stop the immune cells attacking the wrong thing. And they've used a virus to sort of shuttle genetic instructions for that protein into the cells. And with all of these changes together, any cells that have all of these gene edits, that seems to, in their small test, allow these cells to survive without any immune interference for, they say, six months.

31:16Seems like early days, Shalmany. What sort of stage are the researchers at with testing this new approach? Yeah, super early days at the moment, because what they've done is they've basically got one patient, a man with type 1 diabetes, and they've injected a very low dose of their genetically engineered cells into him. So that's 80 million cells is apparently what's referred to here as a deliberately low safety test dose. And looking at it 12 weeks later and then again six months later, they have found that genetically engineered cells are able to produce insulin and are not getting immediately wiped out by the immune system.

31:53So it's not yet at the stage where, you know, obviously what we're going for would be you want someone with type 1 diabetes to be able to, you know, have a treatment that will last forever. so they haven't done that yet and there are people who are quoted in this article as well who are maybe a little bit sceptical at the moment because there's been a lot of other work trying to do this kind of thing that hasn't worked so they kind of want to see a bit more confirmation of how successful it is but potentially this kind of immune cloaking because they're sort of trying to hide the cells from the immune system if you could combine this with the work I mentioned about taking stem cells and having them turn into pancreatic cells.

32:36Some sort of combination of all these could potentially be even a cure for type 1 diabetes, which would be obviously amazing. Well, fingers crossed then that these approaches bear fruit, because as you say, that would make a lot of difference for a lot of people. But in the meantime, let's move on to a story that I've been reading in Nature based on a Journal of Neuroscience paper, and it's about colour perception in the brain? Oh, I feel like when I was sort of studying like second year psychology, there's all sorts of fun experiments you can do about what we're seeing and optical illusions and why we're seeing it and colour.

33:13Is colour real? All sorts of sort of philosophical mind bending things. Well, you're absolutely right. And these are things that have, you know, puzzled philosophers and neuroscientists forever. Are we seeing the same colour? I mean, looking about my desk here. I've got a powder blue coffee cup, a yellow coffee cup, and a pink, I would say, maybe cerise coffee can, which I've got pens in. Maybe too much coffee-related power for a little, I have to say. But of course, the question is, if you sat here at my desk, would you see the same colours in these objects? Yeah, because I might say, oh yes, this is definitely light pink, because we've agreed.

33:48But is my sensory perception, is it the same experience in my brain as it is in your brain? Well, quite. And we'll come on to that in a little bit. But I think what this research has done is maybe just opened that door a little bit into figuring this sort of stuff out. And it's a study looking at patterns of brain activity and exploring how different colours are represented in parts of the brain associated with vision. And the researchers behind this work, they used functional magnetic resonance imaging to compare brain activity in people who were looking at different colours. and they used these results to see which parts of the brain were firing.

34:26And after that, trained a computer using machine learning to look at these patterns and then subsequently predict what colours were being viewed by a second group of people on the basis of their brain activity. So it's a mind-reading computer that can tell you exactly what colour you're looking at. I guess kind of. I mean, it doesn't work every single time, Sharmini. In most cases, the researchers were able to predict what colour was being viewed by the second group. But they also found that different colours were processed in subtly different areas in the same region of the visual cortex. And that different brain cells responded strongly to particular colours.

35:07And this was consistent across participants, suggesting that there are commonalities in the way the brains encode colour. Which sort of partly answers our initial question. And it suggests that if I may massively oversimplify the way the brain works, if there is a red area in my brain, it probably matches up with the red area in your brain. And if we're both looking at red, that's the bit that will light up. But it doesn't speak to the subjective situation that we might find. Are we seeing the same red? And in fact, the researchers themselves even say that. They're quoted as saying, we can't say that one person's red looks the same as another person's red.

35:42So we have this idea that the brains are doing one thing. But of course, this is a small study. It's only looking at a few colours. There's a lot more of the brain to understand. But as I say, it kind of gives this kind of neat insight into the way that we perceive the world. So we still don't know the exact colour of all your coffee paraphernalia adorning your desk. But I think we're progressing. And listeners, if you want to read about all that for yourself, we'll put some links to the articles there. And if you want your very own list of stories in your email every weekday, we're going to put a link to where you can sign up to the Nature Briefing.

36:17And that's all for this week. But if you'd like to stay in touch with us, you can. We're at Nature Podcast on X and Blue Sky, or you can email podcast at nature.com. I'm Benjamin Thompson. And I'm Sharmini Bundel. Thanks for listening.

From the publisher
00:45 Attributing extreme heat events to major energy producers

Major energy producers increased the likelihood and intensity of heatwaves, according to research published in Nature. Using data from an international disaster database, a team developed a methodology to investigate how much anthropogenic climate change had influenced heatwaves. They conclude that many of these events would have been “virtually impossible” without climate change, and that nearly a quarter of the heatwaves recorded from 2000 to 2023 can be directly linked to the greenhouse-gas emissions from individual energy giants.


Research Article: Juvé et al.

News and Views Forum: Heatwaves linked to emissions of individual fossil-fuel and cement producers

News: Dozens of heatwaves linked to carbon emissions from specific companies


10:47 Research Highlights

How shifting coastal tides may have spurred the rise of the world’s oldest civilization — plus, the liquid crystal lenses that can refocus in a flash.


Research Highlight: Changing tides ushered in the world’s first civilization

Research Highlight: Liquid-crystal specs refocus with the push of a button


12:40 The growing resistance to the US war on science

Science in the United States is facing an increasing crisis, in the face of swinging cuts and President Donald Trump’s ongoing attack on anything with a connection to diversity, equity and inclusion. In the face of this crisis, many researchers are fighting back — we hear about some of their efforts, and what they think about their chances of success.


News Feature: Scientists take on Trump: the researchers fighting back


27:28 Briefing Chat

How CRISPR-edited pancreas cells could offer new hope for those with type 1 diabetes, and what brain scans reveal about how we process colour.


Nature: Hope for diabetes: CRISPR-edited cells pump out insulin in a person — and evade immune detection

Nature: My blue is your blue: different people’s brains process colours in the same way


Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.

Hosted on Acast. See acast.com/privacy for more information.

More from Nature Podcast

All episodes