Reid riffs on acquihires, agents, and new startup norms

16 Jul 2025 · 40 min

Ask about this episode

Ask anything about it. ChatGPT or Claude reads this page and answers with the times it was said.

Connect VO and ask about every podcast you hear, including the moments you saved. Add to ChatGPT · Add to Claude

In short

Podcast Notes: Possible - Episode: Reid Riffs on Acquihires, Agents, and New Startup Norms

Episode Summary In this episode of the *Possible* podcast, hosts Reid Hoffman and Aria Finger dive deep into the rapid advancements in AI, specifically focusing on recent trends in startup culture, the changing landscape of business acquisition, and the future of work influenced by artificial intelligence. Recorded live in New York City, this two-part conversation discusses the implications of AI on startups, the importance of adapting to new technologies, and the evolving roles professionals will need to embrace.

Key Topics Discussed

  1. AI and Startups: Building for the Future
  2. Question of Prediction: Reid emphasizes the difficulty of predicting the future of AI, especially when it comes to startup strategies. He argues that entrepreneurs should remain flexible and responsive to the rapid advancements in AI technologies.
  3. Sector-Specific Dynamics: The speed of AI innovation varies across sectors (e.g., SaaS vs. consumer), and understanding these dynamics is crucial for success.
  4. Multimodal AI: Reid references Ethan Mollick's example of using AI for monitoring construction projects, underlining the importance of understanding existing tools and their potential applications.
  1. Competition Landscape
  2. Startups vs. Incumbents: Reid stresses that startups primarily compete against each other rather than established incumbents. Understanding this competitive landscape is vital for new entrants.
  3. Defensibility and Go-to-Market Strategies: Founders must focus on creating defensible business models and effective market strategies to carve out their niche amidst competition.
  1. Acquisition Trends in AI
  2. Hyperscaler Acquisitions: The episode addresses the increase in acquisitions by tech giants, such as Meta and OpenAI, emphasizing a shift towards acquiring talent over products.
  3. New Deal Types: Reid notes that the overly aggressive stance of the FTC has led to innovative deal structures as companies seek to secure talent in a rapidly evolving market.
  1. IPO vs. Acquisition Mindset
  2. Building for Longevity: Founders are encouraged to build durable companies with the intention of going public rather than solely aiming for acquisition.
  3. Shift in Team Composition: The emergence of AI suggests that smaller founding teams may be sufficient, as AI tools can significantly enhance productivity.
  1. AI in the Workplace
  2. Agent Management: As AI tools become ubiquitous, professionals will need skills to manage AI agents effectively, prompting discussions about the future of business education and MBA programs.
  3. Human Skills in an AI World: While technical skills may evolve, Reid posits that human-centric skills will remain critical for teamwork and social interaction.
  1. Healthcare and AI
  2. AI Potential in Healthcare: Reid shares insights regarding the transformative potential of AI in healthcare, including its ability to deliver faster and more accurate diagnoses.
  3. Case Studies: He presents a real-world example of AI providing a potentially life-saving second opinion in a medical scenario, highlighting its practical applications.
  1. Philosophical Considerations of AI
  2. Human Purpose and AI: The conversation touches on concerns regarding AI's impact on human purpose and creativity. Reid remains optimistic about humanity's ability to adapt and find meaning, even as AI begins to take over more tasks.
  3. Creativity and Human Interaction: He argues that human relationships and social interactions will continue to provide meaning even in a future filled with AI.

Key Takeaways

  • Flexibility in Strategy: Entrepreneurs must remain agile and responsive to changes in AI technology and its implications for their sector.
  • Focus on Core Competencies: Understanding competitive dynamics and creating defensible business models is essential for new startups.
  • AI as a Tool: Emphasis on AI's role as a productivity-enhancing tool rather than a complete replacement for human roles.
  • Importance of Human Skills: Despite technological advancements, human social skills and interactions will remain fundamental to workplace dynamics and personal fulfillment.
  • Healthcare Innovations: AI has the potential to revolutionize the healthcare sector, making it more efficient and accessible.

Conclusion This episode of *Possible* provides a comprehensive overview of how AI is reshaping the future of startups and work, emphasizing the importance of adaptability, talent acquisition, and the enduring value of human relationships in an increasingly automated world. The conversation sets the stage for the continuation of these discussions in the next episode.

For more information, visit [Possible podcast](https://www.possible.fm/podcast/).

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Hear the part that matters, and keep it.Open this episode in VO. Double tap your headphones to save a moment as you listen.
Get VO free

Transcript

Automatic transcript. May contain errors.

0:28I'm Reid Hoffman. This week, in part one, we're sharing my live conversation with Reid. And next week, we'll dig into those listener questions. So without further ado, here is Reid Riffs Live.

0:43So I think we're going to start off with the hardest question. One of the things Reid always says is anytime someone says, oh, here's what's going to happen in 10 years, they're probably an idiot. It's really hard to predict things that are 10 years in the future. But I feel like all of the time on Twitter, people are always saying, don't build for the AI we have today. Build for the AI that we have tomorrow. This is moving so quickly. You need to anticipate where AI is going to be, and you need to build for that. But how do we correctly anticipate what tomorrow is? Is it the AI of next week, the AI of next month, a year?

1:19And I know this is an impossible question because it matters the sector. Is it SaaS? Is it consumer? but just give us a little idea what AI should we be building for? And two hours later, we finish the answer to question number one. Oh, yeah, read 30-second answers, please. And so, look, as the question well sets out, what you have to look at is the classic kind of startup things, which is what is the zone in which your competitors are operating in? What is the zone in which the speed in which technology, AI in this case, is changing for this? What is your go-to-market strategy? There's a set of those things.

1:53And so the answer will be different, not just on sectors, but it's also kind of a question of, you know, making some predictions about which of the different threads both we see currently that are iterating and improving and also which ones we see coming in. And then at what speed. So, for example, we all know that there is an intense amount of effort around everything that gets to do with large language models, you know, coding, text, work, productivity, et cetera. and part of what that means is you go, I know what it's going to be in three years. It's like, no, you probably don't. And so you really have to be dynamic and really updating quickly for that.

2:32If you're in multimodal and you say, well, for example, one of the things that I learned from Ethan Mollick that I thought was super interesting and many things, but as an example of where Ethan was showing that people are just not even, like are way under utilizing these tools that exist today, he said, hey, you know, like one of the difficult challenges is construction projects. And like, namely, is it on track? What might be running slow? Et cetera, et cetera. And he literally uploaded the construction plan to an AI, put, I think it was like 20 cameras around it, and then asked, how's it going?

3:07Like, had it every day, every hour, ask how it's going. And it gave a pretty accurate construction report of this is what's running slowly, this is how the work really ran today, et cetera, et cetera. And that already exists in multimodal. But multimodal is probably one of the ones where, you know, where it's because, you know, error rates and all the rest. And where does that matter? And, you know, like a monitoring thing, you know, you could be wrong and you can go check it and so forth. So it's one of the things that multimodal is in the middle. And then you've got things that are a little bit longer out, which is even though people are intensely doing science and everything else, it might be the where will the various forms of science acceleration models happen.

3:46And so you get all of that factor. but a lot of it's the kind of classic, you know, what's the speed of the competition? Like a lot of entrepreneurship is about competition, not usually the mistake of thinking it's per competition with the large players. Usually it's other startups and, you know, how many of them are they on the same path you are? What is the go-to-market? What is the defensibility of the thing that you establish once you're there? And all of that plays into it and the timing on the AI model and trajectory of where the hockey puck is moving to depends on that. Can I just pick up on one thing?

4:21We have a lot of founders in the room. You said the mistake that some people make is they think the startups are competing with incumbents, but they're really competing with other startups. Say a bit more on that. Well, so mostly all organizations, small, large, have, you know, call it a small number of priorities. You know, the memory thing is most people can remember seven plus or minus two things with a little bit of an emphasis on minus two. And organization tends to be like three things, plus or minus two things. And so, for example, if you're trying to do is say, hey, I'm going to go build a new, call it office product suite, and I'm going to do it that way, and I'm going to go to market, you're going to have a challenge because the giants are actually, in fact, really fighting with you on this.

5:08It's like I'm going to do desktop search. Now, by the way, of course, like one of the things, If you haven't started experimenting with putting the chat GBD plug in to interrupt your search and do it, you should. You learn interesting things from it in terms of where it's ready, where it's not, and all the rest. But the typical thing is, well, does Google, Microsoft, Amazon, Apple have a small group working on your startup project? Yes, they probably do. And who cares? Depending on if it's not one of the three plus or minus two things that the organization is doing. And so, as a matter of fact, it's almost like a little bit of validation if you say, hey, I'm working on this thing and there's a group at HyperscalerX that's doing it.

5:49Now, the asterisk, the reason why, that's the general software startup advice. My asterisk is a little bit of, there's also, there's an intensity to the play here in how AI software is constructed that involves scale compute, scale data, scale teams. And it doesn't mean that startups can't do their own models and can't be doing things. But if you're suddenly in the, I have to be playing scale across those vectors, then all of a sudden you better have a good strategy of the game there. So let's talk about those hyperscalers. Let's zoom out. In recent weeks, it's been a little nuts. We had Meta's investment in scale AI at 49%.

6:30We had OpenAI pay$6 billion for Johnny Ives startup. There's talk of Nat Friedman and Daniel Gross, Aquahire, to go sort of be the meta dream team. Is this like a new era in the AI world where in the past we had acquisitions and now we care more about talent than we do about product? Is this a new wave or is it just a blip that we're seeing? Well, it's a new wave partially occasioned by what I have, in a couple of different ways, said is an overly aggressive FTC, where the notion is we're trying to prevent future issues that look like monopolies versus current ones. And so that kind of thing is actually very anti-business, very anti-venture, very anti-constrained.

7:25And that required a bunch of innovation for some new deal types. So it's new deal types have now, I think, been definitively added. But not having been anywhere in the room and having any specific intelligence. But I suspect that if Meta thought that they could have just bought scale, they would have just bought scale. It's much simpler, doesn't require all this, other sorts of things. Now, there are a couple of footnotes in these deals that are interesting. The basic thought is we're in the largest technological revolution that we've had in human history, that the outcomes will create companies that are in the tens, hundreds, billions, and even, now we say trillions of dollars in value.

8:06And so key talent might actually, in fact, be worth not just millions, but tens of millions, hundreds of millions, and maybe even billions in order to do that. And that still fits within the envelope of how, you know, talent is generally valued within companies. Because the framework is usually like, you know, if I pay you, you know,$10 million because I'm expecting to make$100 million off the platform in terms of doing it. And that's part of how shareholder value, collective value in the company, and all the rest of the stuff is built. But even with that, because of the anticipation of value is so high within some of these AI companies, that that's the bets that are being made.

8:47And it's not crazy. Should the people in this room do anything different? Like, obviously, there's still the path to IPO and the IPO market is opening up a bit. But do you build any differently when you're expecting this path versus a pure acquisition? You know, I was actually just before this talking to, you know, one of my partners who works here in New York, Seth Rosenberg at Greylock. And I was just talking to him about this. And part of the thing is to say you always build for an eternal company. You build for it's going to go public, it's going to be big, it's going to change an industry.

9:21And you change other things based on it. Now, the pattern of how you're building might change. Because the pattern of how you're building might be like, okay, for example, one of the things that's a near certainty is within a small number of years, could be as small as two, could be as great as five, that if you're a professional and you're deploying and you're not deploying with multiple agents in what you're doing, you're under-tooled. It's a little bit like saying, I'm a graphic designer and I don't use Figma or Photoshop. Where it's like, no, not really. You're not a graphic designer. You might be something else, but you're not a graphic designer.

10:03Or I'm a professional. I have neither a computer nor a smartphone. It's like, no, no, that doesn't really work that way. And so that will be intensely there. And that will change certain patterns. For example, one of the things that we've got classically within management is this notion of there's individual contributors and there's manager plus doers and there's managers of doers and then there's executives of managers and so forth. And when you go all the way down to the individual contributors in this universe, here's an interesting question. I won't make a prediction as per your earlier thing.

10:41But when will MBAs start, business schools start teaching classes on how you manage agents? Right? Because each individual contributor will have to have managing agents as part of their skill set. I thought you were going to say, when is the MBA going to become irrelevant? And perhaps the answer was 10 years ago. Well, I usually say that my degree in philosophy is more relevant than an MBA. Exactly. Exactly. Exactly. The philosopher entrepreneur. Okay, so going to go back to, all right, if we're building today, we need to think about the AI of tomorrow. Everyone's talking about what your moats are.

11:19It's like it used to be, was it network? Was it product? Today, it's like the magic of AI. You think something's great, and then next week, it's just table stakes. So in this new era, is it a proprietary feedback loop, your distribution wedge? What is the moat that these companies should be looking for? Well, so first is most of the classic modes still apply. You know, you get integrated into an enterprise workflow, and part of what happens, that's a defense. You have a network effect of, you know, of multiple sorts. And most people, of course, think network effects. They think LinkedIn and, you know, Facebook.

11:55Never heard of it. Yeah, whatever. This is a small company. And so, you know, they kind of think all those things. But there's also various forms. For example, one of the very original network effects in modern software was in Microsoft's Office product suite between the data file formats and the application. So there's lots of different places. And one of the, of course, key things to look at is where might there be network effects because they're one of the really key things that happen. Where might there be network effects that are new patterns within the AI thing? And most of the pitches that I've seen on that so far are more kind of impressionistic.

12:32you know, Jackson Pollock-ish than systematic, but, you know, I think there will be some. Obviously, you know, some part of the question is, you know, as you're solving certain kinds of problems, certain kinds of data set that really align to that will be very relevant because, you know, surprisingly, large models, GBD4, Gemini, Copilot, et cetera, can actually do a fair amount of medical stuff because there's just so much content out there on internet but as you begin to get to more kind of more specific things like okay drug therapy you know and and and reactions the data sets on those things actually in fact really matter so there'll be various things on data sets and so there will be some new patterns and obviously one of the patterns that are that the hyperscalers in particular focused on is scale compute you know we're still not quite sure where the scale compute really starts delivering sharply asymptotic value it's it's not to say that there won't be and all the rest and that's actually one of the questions that get into all the discussions of this and and by the way sometimes you know as you get to different orders a level of magnitude getting the models to um to to you know kind of uh congeal can come together in the right way actually has some added difficulty.

13:54It's not just apply 300 ,000 more H100s and everything is great. There's ways to try to make that happen effectively. But that's another one, and that's actually one of the things that makes the software game a little different because you say, well, actually, in fact, I've got a self-learning system that creates the real competitive advantage, but you actually have to have X hundred thousand H100s and when to do that, then that's less of a startup game and more of a hyperscaler game when you include OpenAI and Anthropic and other folks in the hyperscalers. So speaking of LinkedIn, which does have six times the revenue of Twitter, not that anyone asked, but just for the record annually, you launched LinkedIn over 20 years ago.

14:40And you had your co-founders, you had your first few hires. How does that look different than how AI teams should look today? Is it just less people? Is it mostly engineers? Do you wait a long time for that first business hire because you can do so much with ChatGPT? How is that different from 20 years ago? If you're starting a company from scratch and everyone in the company is not using AI aggressively, I mean, anyone who's not using AI aggressively, and I call it a seed or a series A company, I think you probably want to get rid of them. And if you're the founder, then get rid of yourself. So it's like, because it's where the puck is moving to and all the rest and understanding.

15:23It doesn't mean it'll be perfect for everything. It doesn't mean it should be used for everything, but that kind of cycle. And that means you'll have an amplification of productivity across the entire set. And so it allows a few new corner cases, like, for example, like maybe the cost of, as opposed to, oh, our minimum viable thing, like roughly speaking, I started LinkedIn, kind of call it the minimum viable company to really get stuff going was like kind of in the 10 to 15 people. Like, you know, when we at Greylock led the round on Instagram, it was 12 employees, right, as an instance. And so, you know, like that's kind of the set.

16:02And maybe now six people or five people or three people, you know, as kind of, you know, how that plays out. Maybe what you can do with one person is now much more amazing. And so there's some weird corner cases. But on the other hand, this is relatively small. And so, by the way, people who can't otherwise get seed capital or national can start early, it'll mean things for universities and university projects, you know, doing things. And so all of that opens up and it'll be very good. On the other hand, once you get into the kind of venture line, you know, the difference between funding 15 people and seven people is not that big of a difference or 15 and 25 people is not that big of a difference.

16:39And so I think it'll be less like, oh, we're not just now doing a lot more with the people. And I think that will be a plan. And so I think it'll probably be, you know, like getting to the blitz scaling, you know, kind of phenomena. Like the speed of motion is now, in many cases, especially when you have small teams, going to be absolutely important. The question of, you know, will people be fast following your particular go-to-market motion? You know, that's going to be relevant. So there's going to be a whole stack of kind of new patterns here. And by the way, in this regard, while there's new patterns, it's not like, oh, AI is the only time new patterns have happened.

17:14I mean, part of the thing that between my first startup, SocialNet, and PayPal, and then LinkedIn, is kind of like, how much do you have to have sun equipment, right? And Unix boxes that you're doing on-prem is just going down to the floor. Like, probably a lot of people here are like, what's a sun box? Anyway, but, you know, like, so it's a new set of tools, a new set of play, but that's not unheard of to change the game, the software game. Sounds like you're saying we're still going to need these, or perhaps not need, but once we get into the venture space, yeah, you're still going to have 15 employees.

17:48You'll start at six. You'll get to 15. You're just going to move more quickly. And so maybe that means that you're going to get to revenue more quickly or more revenue more quickly. So from the venture side, I mean, we've seen some eye-popping seed rounds lately, but forget sort of the Miramiratis and the one-offs. is venture just going to be investing earlier or are they going to be investing with more revenue and at the same stage? How does that change in the age of AI or the age of quicker work and more, just the speed is going up so fast? Well, I think there will be Crimea River for VCs, even though we're here with Village and sets in the audience and all the rest.

18:29It'll be harder because you can possibly blink and miss it more quickly. And so speed of decisioning, speed of making an offer, taking risks before there's super traction, et cetera. I mean, you tend to get this kind of barbell approach where either you have to go seed or you have to go growth. And the intermediate becomes kind of to some degree harder. Now, seed's always somewhat hard because you're like, okay, will they figure out kind of product market fit? Will they figure out something that will get to scale product market fit? And then in growth, a lot of it's kind of like, okay, well, how big does this get?

19:04And is it going to work? And then one of the things that frequently, once upon a time, Silicon Valley was very derided from and I think now is no longer, is you're not just taking product market fit risk or entrepreneur risk or competitive risk, but actually sometimes you take business model risk. And I suspect that one of the things we're going to see a lot of, kind of like almost like the parallel from the early internet to now with AI, is we'll see a lot of business model risk.

19:39so we're going to switch gears um my co-worker thanasi put this question in the question set because he knows what a huge fan of crypto i am so here we are we're going to talk crypto resurgence regulators uh have a have a changed posture towards uh crypto with the new administration We saw Circle IPO. It's up 620%, I think, as of today. And crypto prices are still wildly swinging. Perhaps we're just looking at memes to see what's going to happen. But there's also the Genius Act, which passed the Senate and is waiting to pass the House. And they're going to insert some regulation into the crypto market so this can be a stable financial game.

20:26Or not? Or are meme coins going to continue to run the show? Well, you know, as you know, usually when you say A or B, I say mix both, you know, etc. As a matter of fact, I think it was Ben Casnoka from Village who said, you know, your tagline should be nuance. It was kind of a fun observation. So one, look, one, genius stack rate. because actually in fact you know getting to more frameworks in which you know there's kind of clarity of regulatory space for entrepreneurs to act in for financial system to interact with to be clear between those is actually in fact a really good thing I think that's a very strong set of progress you know generally speaking you know kind of the pattern should be as like look what's the way that we should bring it into the financial system what are the kind of regulatory controls for whatever your particular concern is and what you'd be doing relative to that regulatory concern is the thing to be generally doing versus, you know, kind of the just hit with stick, which was one of the failure points of the previous administration.

21:33You know, I think that's a very, very good thing. And I do think that, you know, when you get to, for example, stable coins with the Genius Act and the balancing with the dollars, it's actually good for the overall dollar ecosystem. It's good for actually the world because a lot of different places, you know, can use stable coins now for financial trading systems, whether it's Venezuela or any other place. And I think that's a very good thing. But there's still a long way to go in terms of what all the use cases that people are describing, whether or not it's digital identity, you know, digitization of assets, you know, kind of scarce digital commodities, all the rest.

22:10and of course we will have lots of memes. And they may even be named after a president. Who knows? Who knows? Who knows? Perish that thought. It's a science fiction universe. So as we said, you are a philosopher entrepreneur. You got your master's in philosophy, not an MBA. And so switching to a more philosophical question. One of the things that people worry about in the age of AI is losing meaning, losing purpose, whether it's because people think there won't be jobs, so people won't have careers to give them purpose. I don't know, if we don't do the dishes every day, how are we going to find our purpose with AI creating video and content and creativity?

22:52And so what do you think about the direction that AI is heading in as it relates to sort of human creativity, flourishing, purpose? Could we go down the wrong path? Or you're convinced that we're still on the right track? A or B, please. Well, if it was Araby, as you know, from Super Agency, which I published over this year, I would say we're on the right track. Now, your setup, the question actually led me think you were going to do one of these tweets that I really loved from last year, year before, which is, I wanted AI to do the dishes so I could do poetry, not AI that did poetry so I can do the dishes more.

23:29I literally was thinking about that. Yes, it sounded like that as you were asking the question. I am ultimately very positive on a human being's ability to kind of figure out how to have a, we operate as a tribe and have a, you know, kind of meaningfulness society. Transitions can be super painful, super difficult, and we might really fuck up the transitions. And we can really fuck them up. I mean, for example, you know, take in China the Cultural Revolution, but many other circumstances where you can actually just deliberately really, really screw stuff up. And, you know, like Venezuela today, you know, like lots of good oil and totally dysfunctional society.

24:10So it's totally doable. And that's one of the reasons why they put a lot of energy in to steer and all the rest. But that being said, like we've kind of run, like if you look at a bunch of the medieval countries, including Europe, if you get to the point where like you know for example ai robots are doing all the work that's essentially like well that's what the nobility were living like when they had all the peasants and serfs and all the rest and and so you know like you have dinner parties and you know have poetry recitals and is you know bob talking to sarah and is sarah still friends with michelle and you know does michelle regard bob you know gossip is really going to increase in the age of AI.

24:50I like that take. Well, it's social. It's an interesting kind of social thing. And so, so I'm convinced, like we find meaning in how we interact with each other, what our positions in society are. Sure. Sometimes it can be, does this person get promoted, gives a higher salary, kind of classic work stuff, but it's also, is this person invited to the party, you know, et cetera. And so I think all of that, I'm not ultimately like, for example, part of the reason why people find a crisis of meaning is they go, well, this thing that I was really good at now gets outmoded. And so, for example, this thing I was really good at, which is I was a human calculator, you know, kind of keeping the accounting books and then, you know, spreadsheets come along and they're not relevant anymore.

25:32But like accounting didn't go away, right? Accounting now became other things, came, you know, scenario planning and strategic analysis. He said, well, AI can do that. It's like, okay, but maybe it's like cross-checking it or training it or managing it or running scenarios of, well, here's the, like, for example, because agents is like, okay, I think one of the things you'll see more of is, well, run five different plans and compare them with each other, right? Because which are outside of our bandwidth now, but like if you said, okay, I'm going to have this group of agents doing that, this group of agents doing that, this group of agents.

26:04Everyone is a manager. Yes, as kind of instance doing. And so I'm both bullish, a la Stay the Core Superagency, on even if we get to the Star Trek kind of science fiction, but also I also think people tend to overstate how quickly, you know, like work's going away. Um, you know, I, I, uh, teased Dario a little bit about white collar bloodbaths. It did get a lot of headlines. Yeah. Um, and, um, because I actually think that the transitions will be real and that's the thing that I think Dario was trying to emphasize, but I think human organizations and human institutions, we kind of move at the speed.

26:44We might be accelerated, might be pushed into it, but we kind of move at the speed that we need to competitively because we're kind of happy with the environment we're in. Now, challengers, entrepreneurs are always doing the new thing, the different thing, and seeing if it can stick and seeing if that can work. And that will ultimately also pick up the pace on this stuff. So a related question that we get a lot is, of course, your answer is going to be, if you're in the workplace, you have to use AI. Everyone is going to have an agent, a co-pilot, doesn't matter what profession you're in. but what are the sort of more human skills that are going to be important in the age of AI?

Read the full transcript

27:19Well, I think there's a stack of human skills that will obviously persist because to some degree, like I don't, it'll be interesting when we kind of get to, like for example, as a classic, there's an interesting hypothesis of, I'm certain that we will have some AI artists that we will care about in kind of some version. But we might very well have like a few and mostly still just care about human artists. And you say, well, wait, this song, this painting, this sculpture was produced so much more with precision and fine and craft by the eye. It's like, oh, but I'm interested in what other human beings are doing.

28:03And so that, what other human beings are doing, we are, Aristotle said we're citizens of the polis, political animals, but it really means kind of like social. Like we're citizens of the village, the city, et cetera, the tribe. And so we really care about what other people are doing and saying and what our relationship with them, that's part of the earlier kind of like finding meaning and whatnot. And so all the skills to go with that persist. And you say, well, do we care about doing, you know, thinking scientifically, mathematically, et cetera? I think the answer will be yes and not just because even if you say, hey, look, this curve is not going to asymptote.

28:43Ultimately, these devices will be much, much better than us overall. But it still actually, in fact, can be useful because it's like cross-checking, understanding, being able to participate and know where to be in what's happening with the world of AI. In part because, for example, today we all know that part of the creative force of these things also creates hallucination. And being able to be aware of, well, did it matter in this circumstance. And so, anyway, so, look, yes, all these classic human skills, but I don't think the other skills, I think they change shape. I don't think they go away.

29:18It's a similar, like, hey, what I'm really good at is you say, what is 112 times 276? And some people go, I got you an answer right now. And other people go, I pulled out my smartphone. It's fine. Right? So it changes in terms of how those play. If no one's taking computer science right now, who's going to train and tune the models in 20 years? We absolutely still need expertise. And part of computer science, here's a more interesting depth point of view, which is every profession will evolve to the point where part of that agents that you're managing, one or more of them will be software construction agents.

29:58So the way that you operate as a professional, anything from accountant, lawyer, doctor, teacher you know small business owner etc you'll actually be thinking in software patterns in part because that will be the way that you elaborate with your businesses and maybe a lot of those software patterns will be scripting etc in terms of that but that's an inevitable truth that's a computer science way of thinking and by the way that doesn't mean that that's the only computer science thinking because you know the question around like you know there's all kind like for example today, you've got vibe coding.

30:33It's very cool. If someone came to me and said, I'm vibe coding the efficiency of my hyperscaling server stack, I'd be like, oh, have someone else invest in you. And then let me know how it goes. You'll pass. Wishing you the best. Yes. And that will change, but that's the way. So we have a lot of founders in here who are focused on AI and healthcare. And I've been lucky enough to have a front row seat to the company you co-founded called Manus AI. And to me, healthcare - Which is based here in New York. Which is based here in New York, the capital of AI, I would say. I haven't really heard of any other cities who do it better.

31:11So based here in New York - Maybe five, but yes. So one of the things I'm most excited about with AI is just the enormous propensity to save human life, stop human suffering, get rid of terrible paperwork as it relates to when you go to the doctor's office. Tell us what you're most excited about as it relates to AI and healthcare. Feel free to talk about what you're doing at Manus. It's been really exciting to watch. Well, I'm going to only say three things. I think it's one of the things that really matters. The first is, and I won't say the name because I haven't gotten permission from this entrepreneur, but this entrepreneur was hiking with a cousin of his.

31:53They went to a local hospital because the cousin was having some problems. The local hospital said, oh, you're fine. You know, take a cup of Advil. Uh, my friend checked a chat GPT in this case and the chat GPT said, take him to another hospital and took him to another hospital. And the prognosis was if you got near two hours later, he'd be dead. So second opinion, right? It's a very good thing to use as a second opinion, even today. It doesn't mean first opinion when and how and so that doesn't mean it's it's always wrong in a first opinion but but as a second opinion killer because the second opinion will in part will tell you you know should i get a third the second thing is i think that the notion of like part of the thing like yes we're going to have all of these you know kind of transition issues and workforce and so forth and people like why should we have to do that i'm very happy with where i am why should the technologist be allowed to do this common discussion thread etc etc and it's like well look actually in fact we have line of sight to a medical system that's better than today's average you know today's gp that's available 24 7 that can run for less than five dollars an hour legal assistant education tutor etc and the human elevation across all of that is simply worth a massive amount of transition and we should be getting that.

33:18And so, and like part of what you can imagine, like, I think this is a trivial part of how healthcare will evolve is very rarely when you go up and say, Hey, Ari, you're my doctor, start talking to me about this. It'll be when I show up, it'll be the, okay, give permission for your agent to talk to my agent, download all that. Now let's go into that because I've already been interacting with my agent. And by the way, when I'm in single payer systems like NHS or others, that can be part of the whole triage. Like, you know, medical care always has to be rationed. You can't afford infinite, everything for everyone.

33:52That's part of having an economy. But today it's kind of blunt force. It's like you have some concern and you're not going to the emergency room. Fine, we'll schedule you for six weeks because you're in the queue. Well, some people should be never in the queue whatsoever. Some people should be showing up today at the emergency room, you know, this minute, and then everything in between. The efficiency gains are enormous. But the efficiency gains, allocation of resources, all the rest, helping you with the other things. So it's not just kind of a, hey, you know, is this rash something? Or, you know, can I take ibuprofen when I'm on this drug?

34:26Or other kinds of things, which you can actually already do as part of the one-on-one medical system. Stuff, but like that kind of thing. And then you, of course, get to a menace, which is, you know, part of, and actually, you know, I was having a discussion with a bunch of my partners at Greylock, including Seth, and I was saying, look, I think there's going to be a whole bunch of work productivity stuff that's going to be really interesting. I think there'll be some consumer stuff that will surprise all of us that we need to look for. I think there'll be coding agents, et cetera, et cetera, all of which is great.

34:57I'm happy to help. But what I think one of the places that we have is a blind spot is when it's not just pure CS and it's CS plus other things. Now, obviously, sometimes it gets done into robotics, and when will robotics happen, and, you know, da-da-da, and there's a whole thread we can talk about there. But, like, for example, drug discovery, right? It's kind of when you go atoms and bits, you know, kind of biological, or kind of in the middle, and it's closest to the zone of bits and what you're doing in software. I think there'll be a ton of stuff here. But the problem is you can't just do it.

35:32Like, a lot of CS people think, oh, you do it all in simulation. They think, oh, you just create an AI drug researcher and press play plus 100 play. And it's like... You need a wet lab. You need things to work in the real world. And you need to understand kind of what this data set is and how this works and configure. But these new tools are simply stunning, not obviously just the recent Nobel Prizes, but in terms of how this plays. And so I think drug discovery. And so part of how when I start thinking about these things, I go start talking to the smartest people I know. Siddhartha Mukherjee was one of them.

36:05And I was actually having dinner with him here in New York. And he, I kind of ran him through, he said, oh, that's a really good thesis. And I said, and I was like, great. And it's like, because, you know, I had known Sid not just as the brother-in-law, one of our partners, David Zee, not just as the celebrated author, Pulitzer Prize winning Emperor of All Maladies, a bunch of other books, not just as one of the most famous smart cancer doctors on the planet, a professor of oncology at Columbia, but those are the things I know and as a friend I just know him as and he says well you know I've actually brought drugs to market and I'm like what?

36:39He's like yeah I've helped start up a number of companies this sounds great let's talk about this and so I got a literally crash course of hours and hours and hours of what the drug discovery process looks like and part of what we were doing was bouncing back and forth between okay this is what AI today looks like this is why probably AI in one year and three years here's some of the tools that everyone knows about here's some of the tools that very few people know about where can they make a difference in each of these places you know and what kinds of things to do and that's part of how manis got started well i and the mission of manis is to use ai to cure cancers and this was sid's fundamental thing because you know part of the thing is like look cancer kills everybody all age groups etc and it's fatal and our current attempts at therapy are brutal and if we could do it this way massive unlock of value for everybody

37:37Possible is produced by Wonder Media Network it's hosted by Ari Finger and me Reid Hoffman our showrunner is Sean Young Possible is produced by Katie Sanders Edie Allard Tanasi Delos Sarah Schleid Vanessa Handy Aliyah Yates Paloma Moreno-Gimenez and Mulea Agudelo. Jenny Kaplan is our executive producer and editor. Special thanks to Surya Yalamanchili, Saida Sepieva, Ian Alice, Greg Beato, Parth Patil, and Ben Rallis. And a big thanks to Jennifer Whiting, Sheila Goodman, Ben Casnoka, and the whole Village Global team, Robert Kingsley, Jerry Madlambaya, Samuel Henriquez, the Ritz-Carlton, and of course, Vincent Lucero.

From the publisher

What’s the deal with hyperscalers’ recent string of acquisitions betting big on AI talent? When will business schools start requiring classes on managing agents? And how is—and isn’t—AI changing the path to scale and the future of work? Aria asks Reid about all of this and more in a special two-part Riff, recorded for a live audience of AI leaders and founders in New York City in partnership with Village Global in June.  

Special thanks to our friends at Village Global for co-hosting this Live Reid Riffs. Tune in next week for Part II of the conversation. 

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/ 

More from Possible

All 83 episodes
Reid riffs on acquihires, agents, and new startup normsPossible · 40 min
Listen in VO