Cutting Through the Noise: Dr. Muneeb Shah Debunks Skincare's Biggest Trends

13 Jul 2026 · 37 min · 13 chapters

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In short

Dr. Muneeb Shah discusses skincare misinformation and trend-driven product marketing, explains his Remedy brand approach, then addresses skin effects and skin-care strategy for people using GLP-1 drugs, plus broader “longevity” and responsible science communication online.

Guest

Dr. Muneeb Shah, dermatologist and major online educator (20M+ followers). He previously educated patients in-office, later expanded to social media and built/expanded his skincare line Remedy; he also consults/develops products for other brands and works on dermatology policy committees (American Academy of Dermatology).

Key claims

Launching is easy but making “good” formulas is hard (stability testing, nuance). Viral ingredients (e.g., PDRN) can be valid but trend-chasing stock formulas don’t build lasting trust. Start with patient needs; use evidence-backed ingredients (retinoids, AHA/glycolic acid, ceramides, niacinamide, azelaic acid, some peptides). For GLP-1 “Ozempic phase” (rapid weight loss), topical collagen-supporting actives help but can’t fully reverse deeper fat loss; nutrition (especially protein) is critical.

Notable examples

“Finger trick” myth for eye cream; unstable vitamin C required ~30 trials; rapid weight loss (e.g., 30 pounds/month) leading to crepiness/looseness; possible immunologic reactions (antibodies, injection-site reactions, flu-like symptoms) and parallels to PD-1 inhibitor immune side effects.

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

Tap a time to open that second in VO

Journey to Launching Remedy

0:46 to 2:32

Dr. Shah shares his motivations for starting his skincare brand Remedy.

“I mean, what you've created is extraordinary, genuinely.”

Debunking Skincare Myths

2:33 to 6:36

Discussion on prevalent skincare myths and the importance of evidence-based products.

“You know, content was a hill at one point and this is my new hill is building a brand that really becomes a legacy brand.”

Impact of GLP-1 on Skin Health

6:37 to 12:30

Exploration of GLP-1 medications and their effects on skin health during weight loss.

“And I think I've definitely, as a consumer fallen prey to a lot of products like that, where it really does like hurt your skin health for a long, long time.”

The Role of Nutrition in Dermatology

12:31 to 13:13

Importance of nutritional awareness in dermatology and patient care.

“But that's not going to, like if you've lost a ton of fat or a lot of muscle, your skin might be healthy on the top surface collagen and your epidermal layer, your dermis and your epidermis.”

Longevity and Dermatology Trends

13:14 to 14:00

Discussion on the emerging trends of longevity and their implications in dermatology.

“What should you be measuring at regular doctor's visits?”

The Current Landscape of Skincare Information

14:00 to 16:46

Explore the increasing accessibility of skincare information and treatments.

“And do you think we're putting that cart before the horse?”

Regulation and the Future of Skincare Treatments

16:46 to 19:31

Discuss the need for regulation as new skincare treatments become more available.

“actually, maybe I should try to figure out where I'm getting these things from.”

Collaboration in Healthcare for Better Outcomes

19:31 to 23:11

Highlight the importance of multidisciplinary approaches in healthcare.

“I'm just wondering where all the immunologists are and this whole like peptide conversation.”

The Responsibility of Science Communication

23:11 to 25:58

Examine the challenges of communicating scientific information responsibly.

“And people don't have to go to multiple doctors.”

Navigating Nuance in Scientific Discussions

25:58 to 28:00

Understand the importance of nuance when discussing science and health.

“And so what is your take on that in terms of being responsible with content creation?”
Show all 13 chapters

Navigating Uncertainty in Skincare Claims

28:00 to 30:16

Learn the importance of nuance and humility in discussing skincare safety and trends.

“but there is data that they absorb into the body more than we thought they did.”

Building a Presence as a Young Dermatologist

30:16 to 34:34

Discover valuable advice for young dermatologists on growing their influence authentically.

“I try not to be the first to react to anything.”

Expanding Opportunities in Dermatology

34:34 to 36:53

Explore unique opportunities for dermatologists beyond content creation, including industry involvement.

“I think more experts need to be doing it because there's more misinformation than there is good information still.”
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Transcript

Automatic transcript. May contain errors.

0:00Hey guys, welcome back to Skin Anarchy. This is a very, very special episode and I am truly honored to be hosting our guest today. He is literally the trailblazer when it comes to dermatology communication and like educating us online. He has over 20 million followers. Many of you might recognize him. He was on our show very early on and I was so honored to host him back then. And since then, he's launched his own skincare line and has expanded so much in this space. So without further ado, please welcome Dr. Muneeb Shah back to the show. Welcome Dr. Shah. Thank you.

0:29Dr. Muneeb Shah:Thank you for having me back on. The first time was a blast. I have a ton of updates, life updates. You know, I think this is even before Remedy and before I had my daughter. So, you know, life is very different than it was the last time that we chatted. I know you've been absolutely killing it. And I mean, I am a huge, huge fangirl of Remedy. I mean, what you've created is extraordinary, genuinely. And I think it was when I first saw the line, I was so excited that you made it the way you did and the way the products just sit in this space and what they do. But all that aside, I want to get started.

1:00And I actually would love to learn more about what made you want to start the brand? Because I know we didn't get to talk about that last time. What made you want to go in that direction?

1:09Dr. Muneeb Shah:Yeah, I think there's the education piece, right? And initially, I was seeing patients in the office, right? And each patient I was educating in a very bespoke way. And then pandemic hits. I'm scrolling TikTok myself, seeing a lot of misinformation. I find this opportunity to educate people at large. and sometimes it's hard to get the nuance that you would in a patient room where you're knowing the person specifically and their needs, but you try to get a broad message that's generalizable and can have an impact on lots of people around the world. And I started to work with lots of brands in different capacities.

1:41Dr. Muneeb Shah:A lot of what people see on social media is when I do any sponsorship work, for example, but those sponsorship work a lot of times turned into consulting work, contracting work and development work. So I started to develop products for lots of brands and I realized that there was this opportunity to really take more risks with the brand, make products the way the dermatologist really treats skin in clinic, combine multiple ingredients into one formula so some people can get more impact from their formulas. And so I just saw this white space that similar to content where it's like, you can do one at a time in the office.

2:10Dr. Muneeb Shah:This is a way to basically get great products to lots of people with the nuances that I find important. And it's not just about what we put in the formula, it's also what we keep out of the formula, where we source ingredients from, how we look at allergens and as they emerge and they change how we remove them from our formulas. And so it just gives you a lot of control over the formulas to create better products for a large group that I was educating on social media. And so, I don't know, it's my new hill to climb, I keep saying. You know, content was a hill at one point and this is my new hill is building a brand that really becomes a legacy brand.

2:41I love that. And, you know, I think for me, when I first saw the brand launch, it was cool because for so long you were educating on like, guys, this works, this doesn't work, you know? And I remember the first time we spoke and you were on the show, I remember asking you a question. I don't know if you remember, but I was like, Dr. Shah, does the finger trick work for the eye creams? Because back then, everyone was using their ring finger to apply eye cream. And it was like, you know, a common myth. And I remember you were like, you laughed at the time and you were like, no, you know, that doesn't do anything.

3:09And that really speaks to like just how I've seen you in the space where it's like you've always been debunking myths. And so when I saw Remedy, I was like, this is such a cool brand because it's like everything that we know is tried and true, you know, from the dermatology side, like you've brought that forward in a very novel way. And I would love for you to speak on that, honestly, because as you know, right now the industry is so saturated, you know, and there's so many angles people are coming at dermatology with, you know, whether it's like biotech or whatever. And I'd love to get your take on that in terms of what are the things you've noticed over the years that are like, yeah, this is what works.

3:43This is what your skin needs. And this is what it just doesn't need.

3:46Dr. Muneeb Shah:Yeah, it's a good, it's a really good question. And I think it's becoming more and more important. To your point, it's actually easier than ever to launch a product. You know, there's contract manufacturers that have white labeled formulas. You as a brand, if you have enough capital or you have a distribution network, whether you have an audience or have an office, for example, you can just take products off the shelf, throw your label on them and launch them, right? So it's not hard to launch products if you have the capital and the distribution network to support it. It's hard to launch good products because they take a lot of nuance and development and time and stability testing, right?

4:15Dr. Muneeb Shah:Like I have a very unstable vitamin C formula we created that, you know, after, you know, 30 different trials, we ended up with our stable vitamin C formula, right? So there's a lot of nuance to making great formulas that are not white label formula, which is a policy of ours. And so I think for me, it's been the same things that are tried and true over time have been consistent, right? There's lots of trends on social media, right? So you'll see some ingredient like PDRN, which I'm not saying PDRN doesn't have any value or efficacy. It's actually really big in East Asia. And a lot of the derms there are actually the champions of it in East Asia, right?

4:47Dr. Muneeb Shah:Especially the injectable form, right? So I'm not saying that that doesn't have validity or evidence. Time will tell if this is something that stands the test of time. But you have all these really trending and viral ingredients, right? And then you have these contract manufacturers that have stock formulas. And so what you end up having is all you keep seeing is these same products being launched over and over again is because brands go, okay, well, PDRN is popping off. Let me throw my label on this stock PDRN formula and see how it does within my brand, right? And so I think that works to get you a big sales bump, but it doesn't build a brand that people truly, truly love.

5:18Dr. Muneeb Shah:And so our formulation philosophy is we start with a patient need and it doesn't matter if it's trending or not, right? We start with a patient need and then if this is a product that basically would benefit our patients, then we know that eventually someone's gonna find it and benefit from it. And maybe it's not gonna do amazing at launch, but we know that people gravitate towards it because it's a real patient need. Now, there's always marketing, right? On top of it, there's a marketing layer, right? where it's like, okay, I have a product that patients need, but this concept is really trending right now, right?

5:49Dr. Muneeb Shah:Or people really care about like skin flooding. So how do we position our product within this like marketing language that's popular right now or insert ourselves into a trend? But I think the products have to be really great products that people will use forever. And they have to use ingredients that truly have the efficacy studies on them, like your retinoids, for example, that I've always been a big proponent of, your alpha hydroxy acids that have tons of evidence for them. Some peptides have lots of evidence for them, not all of them. Ceramides, you know, for skin barrier. Niacinamide is a tried and true ingredient.

6:19Dr. Muneeb Shah:Azalic acid is a tried and true ingredient. So we really leverage our formulas around these tried and true ingredients. And then maybe when it gets to marketing, we'll try to insert ourselves into a trend, but the formula has to be. And I think if you do it the opposite way, where the product comes from a marketing trend, I think that's where you become really problematic. Yeah, absolutely. No, I couldn't agree with you more. And I think I've definitely, as a consumer fallen prey to a lot of products like that, where it really does like hurt your skin health for a long, long time. And I remember like, even before I started this podcast, there were so many products I tried that were like that are very trend driven.

6:50And I found myself literally buying like 50 extra products just to heal my skin. And so, you know, I completely resonate with what you said. And again, like no hate towards ingredients like PDRN or anything, but it's like, I just wonder like in this industry, like when are we going to get to the point where it's like we have to understand like where the efficacy truly is and like let's hone in on that and like dive deeper you know like let's do more studies let's understand the more mechanistic aspects of these like like as lake you brought up as a lake we don't know nearly enough i think about as lake acid and we could you know definitely learn more so i hear what you're saying actually i

7:26Dr. Muneeb Shah:think the marketing side is actually so fascinating to me because when i talk to my team about a particular product they'll make they'll they'll say something about another brand for example They'll say, oh, this brand has a really interesting surfactant technology in their formulas. And I go, well, why do you think that? And they go, well, the packaging says next generation biomimetic surfactant technology on it, right? You know? And I go, well, what does that mean? So we start to kind of like, you know, work backwards on it. And the marketing element is so powerful, right? Like they're using the same surfactants everybody's got in their formulas, right?

8:00Dr. Muneeb Shah:You know, everyone's got the same surfactant bases. Like no one's inventing new surfactant technologies. And it becomes this marketing layer, right? That's very confusing to consumers. And it's very confusing to even like the more sophisticated consumer, right? Because there's just not enough knowledge about certain parts of a formula that you can really fall victim or prey to that. And it makes you think that this product is either more efficacious or something that you should be spending more money on. And this is, you know, where a lot of people spend a lot of their budgets is like coming up with terminology that is meant to make something seem more advanced or more sophisticated than it is.

8:31Dr. Muneeb Shah:and then you kind of fall prey to that. Yeah, absolutely. And one of the big things I really would love for you to educate us here is since we last spoke, the GLP-1s and like all the effects on the skin has absolutely blown up. You know, I think there's been some education on it, but there's definitely still a huge gap in understanding, like, you know, what are they doing to our skin? Obviously, short-term and long-term. I'd love to have you educate us on that. From your perspective, like if you are on a GLP-1, what are some things that we should know about going into it? And then while we're on their journey, What are things we should care about when it comes to our skin health?

9:03Dr. Muneeb Shah:Yeah. And I'm sure you've heard this before with GLP. GLP-1s are exploding in use, right? So I remember when at first, when people first started using them, like was coming out of diabetes patients who like, I lost a lot of weight. I'm on this GLP medication for diabetes. And then it started to become mainstream for people to lose weight, right? So they were specifically using it as a weight loss, which is not really fully indicated for, but, you know, people are going to do what they want to do to lose weight. And some people are on it for the right indications. But I remember when it was just a few patients that had lost weight from this, and then suddenly it was a lot of patients.

9:39Dr. Muneeb Shah:And then it felt like it was like every patient, you know, and it's probably not, it's probably about like 12 % of the U.S. population is on a GLP, which is a crazy, crazy number if you really think about it. And so now we really have to contend with like, what is the proper thing to be doing while you're on a GLP, if you're going to be on a GLP for whatever reason, medically indicated or not, what is the best way to basically support your health while you're on this? And so the main thing that we were seeing was termed ozempic phase, and they've come with all different terms for this at this point, but it really is just due to rapid weight loss.

10:11Dr. Muneeb Shah:And we used to see it when people would get gastric bypassed too, but it was so infrequent that we never really like thought to name it anything. But now that it's 12 % of the population, we have to really contend with this. Like, what does it really look like? And this is something dermatologists actually don't probably know enough about or spend enough time thinking about because we've never really had to contend with it. But there's also a nutrition element to this that I think is actually very important as a layer, right? Because I could talk to you all day about the skin stuff that's going to happen and we'll talk about that next.

10:38Dr. Muneeb Shah:But there is a nutrition layer here, right? About getting enough protein, you know, because you're not going to want to eat and you're going to be losing a lot of weight and you need to be making sure that you're getting the right nutrients. So you have to have the right, you know, amino acids that you're taking, the right, you know, other supplements that you're taking that maybe you're not getting. You need to be getting enough protein, for example, right? Because there's going to be a lot of muscle loss that happens during this period. There's going to be a lot of fat loss that happens during this period.

10:59Dr. Muneeb Shah:So there's a nutritional layer that's actually very important here. And I think anyone that's on a GLP really needs to optimize their nutrition while they're on it because you're eating less. But what you're eating really then matters and making sure that you have a balanced diet, that you're not under indexing on any particular really essential elements of your diet. So that's one layer that I think derms need to talk about and need to be part of the discussion when you're treating someone who's on a GLP. And then there's like the skin layer and the deeper layers, right? And so during the weight loss process, the weight loss is happening oftentimes so fast that there's nothing you can do to like really, if it was like a gradual, but I think a lot of people are on too high of a dose initially.

11:37Dr. Muneeb Shah:Sometimes even the starter dose is too high. Well, they'll lose like 30 pounds in a month. And when you lose 30 pounds in a month, there's really no skin treatment that can account for that loss of weight to make your skin snap back the way that it should as quickly as it could. It'll take a much longer time to keep up. And so there are a couple of things you can do from like a topical skincare perspective and then a more aggressive skin perspective. So I'll kind of start there, which is the topical skincare element of being on a GLP, which you should be on a retinoid, I think is probably the best collagen boosting or other collagen boosting ingredients.

12:07Dr. Muneeb Shah:So retinoids, for example, whether it's retinol, tretinoin, retinol, whichever one you choose, an alpha hydroxy acid, like a glycolic acid can help stimulate collagen production, your peptides like your matrixal and other peptide ingredients that have been shown to support collagen is something that you should also consider being on during this period. And anything that's going to support your collagen and elasticity, maybe even like a copper peptide, do the elasticity element of the skin to help your skin. But that's not going to, like if you've lost a ton of fat or a lot of muscle, your skin might be healthy on the top surface collagen and your epidermal layer, your dermis and your epidermis.

12:40Dr. Muneeb Shah:But beneath that, you've lost a lot of fat. So you're going to have that crepiness of the skin. You're going to have that undulations of the skin where, you know, your skin is loose. And so what can you do in that case? And that's where you'd probably need to have either wait a long time for your skin to snap back, which a lot of times it does if the weight loss is not as aggressive or, you know, procedures like lasers, deeper chemical peels, and then sometimes even filler in certain areas around the bony structures to really support that weight loss. But, you know, if you lose a lot of weight rapidly, topical skincare can help, but it's not going to solve the entire problem.

13:13That makes a lot of sense. And, you know, it's interesting that you brought up nutrition and I'm glad you did because I also would love to see dermatologists really step into the space of that nutritional component and really educate on like, I mean, all we really hear about is like X grams of protein a day, you know, and we don't really learn about how should you be keeping up? What should you be measuring at regular doctor's visits? You know, those kind of things like that conversation never happens. And it makes me wonder because we have this whole movement right now going on on the longevity side, right?

13:43Where everyone's like longevity everything. But then at the same time, it's like, guys, before we get to the injectable peptides, can we talk about fiber? You know, can we talk about, you know, these kind of things that I'd love to get your take on just longevity and dermatology at large. Like, where do you think we're going right now with this? And do you think we're putting that cart before the horse?

14:02Dr. Muneeb Shah:It's a good question. It is a really exciting time, really in health in general, we're in a really interesting swing, I feel, a very interesting part of the pendulum, let's say. There was a period in which, right, there was really this type of conversation, whatever you call it, whether you call it anti-aging or longevity, is longevity just another word for anti-aging? That could be debated. But these topics, right, of like, okay, I want to live longer and I want to live healthier and I want to do these preventative treatments in my dermatology office, for example, or I want to go to saunas or I want to do these cold plunging.

14:39Dr. Muneeb Shah:Like this type of stuff really only happened in a small subsect of society, right? And these aren't people that generally have a lot of means or have a lot of access, like a celebrity, for example, right? And we exist now in a time that's really, really interesting to me because the information is actually everyone can consume it. Like there is no limits to the amount of information, lots of bad information out there, but there's no limits the amount of information that's out there and the access that people have to it, right? So you could see how anyone lives, right? Someone can go watch a Brian Johnson video and see everything.

15:09Dr. Muneeb Shah:He's like a billionaire, right? And he is doing all this biohacking stuff, right? And he's trying to optimize his life so that he can live better. And he's testing and trying all these things. And, you know, you could, no matter what walk of life you're from, you can log onto YouTube and you can watch what he's doing, right? And so you have access to all this information. Even, you know, you have these AI tools that can give you good and bad information. You have all these influencers that are creating content online. You have all these celebrities that are being honest about the procedures and stuff that we're having done.

15:35Dr. Muneeb Shah:And so we're at this time where we have this like information access and it's actually starting to coincide with an accessibility piece where now you actually, not only do you have this information, but you almost kind of starting to have access to these things as well, right? Like you can just go online and go to a, you know, a peptide, you know, telehealth website and you can order peptides online, right? So now you have the information and you have access to actually do something about it, right? And it used to be, right, okay, if you wanted to get one of these really advanced laser procedures, you'd have to go to some really expert dermatologist that was probably booked out for a long time.

16:06Dr. Muneeb Shah:He's the only one that had the device or she's the only one that had the device and it was going to be very expensive. So it was off the table anyway, even if you heard about it, right? So you have all this information and you have more access because now there's med spots popping up everywhere. You know, anyone can go operate a laser device, whether that's good or bad. Anyone can go online and order peptides, right? So we're at this like really like, okay, what's going on? Like you have all this information and you have all this access. And so this, I think, is an exciting time to watch this happen because on this side of the pendulum, I think, you're going to need this regulation now to come in.

16:34Dr. Muneeb Shah:And this regulation layer, whether it's imposed by a governmental organization or it's going to be self-imposed, right? Because what's going to end up happening is a lot of people have bad negative consequences from injecting peptides, for example. And then they're going to go, actually, maybe I should try to figure out where I'm getting these things from. And maybe this should be regulated and maybe I should look for something that's FDA approved, for example. and then it's going to swing sort of back into a territory where there's like some regulation to this access. And same thing with like med spas, these unregulated med spas, people are going to get injured, unfortunately, and you see cases of that.

17:04Dr. Muneeb Shah:And then people will go, okay, maybe I should actually be vetting the people. Yeah. I know I wanted that laser procedure, but I should probably vet who's going to do it. Right. And here are the ones that are good because, you know, there's some vetting process in place and maybe they're credentialed in some way. Maybe they're board certified even. That'd be awesome. But the reality is like people are going to do what they want to do if they've heard about something and they're excited about it and their friend got it done, for example. So, you know, we're at this really interesting inflection point where I think, you know, experts like yourself, like doing podcasts like these are really helpful because they help people navigate all this information that's out there to make better choices for their skin health and health in general.

17:35Dr. Muneeb Shah:You know, I think longevity is interesting. You know, to me, it's really just what people have always been trying to achieve through anti-aging. And it's just become maybe a bit more of an extreme form of that kind of like looks maxing, right? Like, I don't know if you've seen this looks maxing trend amongst men, but it's really just trying to maximize your looks, which always existed in the bodybuilding community. And now it's just extended to like facial skincare, injectables, hair care, right? So it's just like instead of just the body now, it's extended to the face and they're taking very extreme measures to achieve that, right?

18:04Dr. Muneeb Shah:So longevity is really just similar to anti-aging and to bodybuilding in the sense that it's a more extreme form of maybe maximizing your health. And I think all of us are trying to aim for some degree of longevity. So I'm not against longevity. And all of us are trying to aim to looks backs also, right? But we just, what extent are we willing to go is a bit different, right? And so there's some middle ground here, I guess is what I'm saying. And so we're at this exciting time where there are these really new, exciting peptides that are coming to market that have some like initial preliminary, you know, phase one, phase two studies that are actually really exciting.

18:38Dr. Muneeb Shah:And if they end up panning out to be safe and effective, like they will help lots of people like GLPs. I think GLPs help lots, lots and lots of people. You know, I think there's an epidemic related to weight in this country, an epidemic related to diabetes in this country that was really damaging to health, right? In general, fatty liver disease, you know, cardiovascular disease, kidney disease, for example, right? So it's like, these things are important. And so I'm excited about the technology that's coming out as a scientist. As a doctor, I'm nervous about the access and lack of regulation.

19:08Dr. Muneeb Shah:And once these two coincide with each other, I think we'll actually be in a better place. So I'm, you know, longevity is exciting to me. I'm willing to always try and learn about more stuff. I'm not like one of the fully skeptic people that you'll see online. And I'm not like the fully bullish people. I kind of live in like the middle zone. And so all my takes are always like a middle ground take, you know, on any of those things. I like that. No, I think I'm very much there with you, honestly. And I love everything you said because you know what, what really is very fascinating to me. I'm just wondering where all the immunologists are and this whole like peptide conversation.

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19:40Like I had a conversation the other day with a friend of mine. She's an immunologist. I'm like, why don't you create a video about something? You know, because like peptides, like that's one of the things like it's cool that we're coming up with all these like interventions now. Right. But it's like there is serious science that is way beyond clinical medicine that's coming into play. And I would love to see the PhDs and the researchers that have been working in these fields come forward and be like, yo, that peptide you got at XYZ pharmacy is probably going to lead to a serious immune reaction.

20:12You know what I mean? Like that kind of conversation. And I just don't see it. And it's not that there's anything wrong with peptides. It's just that like what you were saying, the regulatory component, it's not even close to being where it needs to be. And God knows how many years it's going to take, you know? So I wish like there were more experts, you know, that were just like coming out and saying, here's 15 reasons why I say pros and cons, that kind of thing. But I'm with you. I'm in that middle ground too with longevity.

20:38Dr. Muneeb Shah:It's actually a really good point that you bring up on the immunology piece, because it is something no one ever talks about, but actually a lot of the side effects that people have to some of these medications are immunological side effects. Even to your GLPs, a lot of people actually develop antibodies to GLPs. Now, it doesn't mean it's not going to make them effective, but your body recognizes it's a foreign invader and tries to neutralize it. And in an attempt to neutralize it, a lot of people will get injection site reactions. Some people will get fevers. Some people will get muscle aches where I feel like you have a flu every time you inject OZEMPIC, for example.

21:10Dr. Muneeb Shah:And a lot of that is immunologic side effect. No one talks about it, right? And no one talks about like, what does that mean to have some type of inflammatory reaction in the body to something that you're injecting into the body, right? Because our body does a good job of trying to neutralize invaders, right? And you have a really good point. I don't know if you're familiar with the PD-1 inhibitors in oncology, which allow your immune system to kill cancer cells. And I remember when that first came out, everyone's super bullish on this technology. It's like, whoa, we got this new medication. And I remember Dr.

21:38Dr. Muneeb Shah:Maxwell and I, who do YouTube together, we actually wrote like the first case report on like a side effect of these medications, which was the body started to attack the pancreas. And this patient developed diabetes, like type 1 diabetes as a 70-year-old from taking PD-1 inhibitor medications. And now it's common knowledge in the literature that a lot of patients will have immunologic side effects to PD-1 inhibitors. But at the time, it wasn't common knowledge because people weren't thinking about the immunological consequences, self-immunological consequences to being on these medications. And so So it is something that is always not within the realm of thought for a lot of people, but it's a really important thing.

22:13Dr. Muneeb Shah:And I actually think to your point, like an extension of this is we can no longer operate in silos as medical professionals anymore. I was saying about if you're on a GLP, you need to be thinking about nutrition. That means the dermatologists need to be collaborating with nutritionists and gastroenterologists on these types of and weight loss experts on what should we be telling our patients who are on GLPs. Oh, they shouldn't just be getting corrective laser treatments. they should be on a proper nutritional diet. If you're going to be on peptides, for example, like what other things should we be thinking about for your body outside of just like surface level organ based approach to this, right?

22:50Dr. Muneeb Shah:Like there should be a team of people who are thinking about how to approach these types of patients. And so I think there's going to be need to be more collaboration amongst medical professionals, especially as people start thinking about longevity, because longevity is not just the face, the skin, the hair, right? Right. There's the internal consequences of that as well. Right. So it is interesting. Like, I think we're entering a totally new way of looking at how we think about health and medicine. I love that. Yeah. And I couldn't agree more with you. I think I'm excited because of exactly what you said, where it's like, this is a great opportunity for medicine to really come together and be like, let's have like multidisciplinary practices, you know, like let's create entire like epicenters of medicine that are going to target so many diseases in so many different ways and angles.

23:32And people don't have to go to multiple doctors. You know, like I remember I went to an endocrinologist recently and I was asking about like hair loss because I'm getting being older and I'm losing hair. And I was like, should I go talk to my derm? And the endocrinologist was like, honestly, I have no idea what's going on with you. And I was like, how cool would it be if you had a derm in your practice? You know, like you just, you have the same person here. So yeah, I think it's, it's an exciting time, I think, for medicine also.

23:56Dr. Muneeb Shah:A hundred percent. And I think actually that application layer is going to get lost, right, with the developing technology, right? Telemedicine is allowing people to have access to the medications better than ever, right? So say for example, you know, somebody's online, you know, Gen Z, Gen Alpha, I imagine they prefer to do everything online. Could be wrong. There's probably a subsect that want to go see the doctor in person, but probably some of them are like, can I get this thing online? Right? So they go, I got hair loss. They do some research. They go to Reddit. They watch some YouTube videos.

24:26Dr. Muneeb Shah:They watch the podcast. They come back with the conclusion. They ask chat GPT. They come back, they go, well, I need to be on minoxidil finasteride, spironolactone if I'm a female, right? And they go, okay, where am I going to get that from? They go to HIMSS, HERS, wherever telemedicine company offers that, right? They ask for it, they get it, shows up at their door, right? Turns out they have thyroid disease, right? No one asked the question because why would they, right? Because like this element of integrated medicine is being completely removed. That layer is getting completely removed by this process.

24:54Dr. Muneeb Shah:It's like, how do we contend with this, right? There's no way to insert ourselves into this conversation. Like we've been totally removed from this conversation if you think about it. Absolutely. And, you know, I want to actually really point this out because your platform to me has been honest to God, like before I even got to interview you, it has been one of the most responsible platforms I've ever seen from a person who's educating about science because I've never seen you go crazy with anything. That middle ground thing, like you really maintain that. And I want you to really talk about this because you have literally created a movement, you know, in this space of like scientific communication online.

25:29And I feel like when I go online right now, I open Instagram, there's so many polarized opinions. And a lot of times these people, you have these crazy scientific beliefs. That's fine. That's how science grows. But at the same time, there's also a responsibility you have to your consumers, to your audience. And I would love for you to speak on this about creating content that's still educational, but you're not misleading somebody because whoever's watching your content, they're going to interpret it the way they're going to interpret it. And exactly what you were just speaking on, they're going to go and do whatever it is, whether that's like that one of these telehealth pharmacies or whatever, you know.

26:03And so what is your take on that in terms of being responsible with content creation?

26:07Dr. Muneeb Shah:Yeah, we talk about this a lot, actually, internally. Is this valuable to people? Is this enough information? and I think the trouble is short form a lot of times is lacking of nuance. And that's the nature of short form content. So you can't get everything in there, right? So you have to try to see how can I make this still entertaining, get the points across, make sure all the things that are important nuances are mentioned, but then there's always something that's gonna get lost in the conversation, right? So no one I think can get it perfect in short form. YouTube, podcast, I think you can really go into the details where you can make sure that you're caveating everything, you're adding different layers to what you're saying and you can get the point across, right?

26:43Dr. Muneeb Shah:So I think the way we communicate or the platforms we communicate on limit our ability to really be as nuanced as I'd like to be in some cases. But even then with short form content, I try my best to try to make sure that anything really important ends up in that piece of content. I think that as far as like these different polarizing points of view, I kind of see the both spectrum of it. And I see the inclination to lean one direction or the other. There's a lot of people who will say, it's sort of interesting, like let's say we take a conversation like parabens or we take a conversation like fragrance, or we take a conversation, like anything that, you know, has been fear of chemical sunscreens, for example, right?

27:16Dr. Muneeb Shah:Like we take any, benzene, for example, right? If you take any of these like particular topics, right? There's going to be very polarizing views. There's going to be somebody on the maybe deep chemical side that's going to say, hey, these are safe, completely safe, right? And you have these other people that are like, these are completely toxic, right? And it's like, how can both of them be right at the same time? Someone's got to be wrong, right? Reality is like, they're probably both wrong to some extent. And so I think it's very enticing to speak in absolutes always because it's clear and you put your foot in the ground on things.

27:46Dr. Muneeb Shah:But I think when you speak in absolutes, most of the time you're gonna be wrong because there's not enough information out there, right? Like the chemical sunscreen debate, which I personally wear chemical sunscreens. That is a personal decision. You know, I like the way they look on my skin. I prefer chemical sunscreens personally, but there is data that they absorb into the body more than we thought they did. Is that good? We don't know. Is that bad? We have no idea, right? And so to absolutely say these are completely safe and nothing bad will ever happen to you, that's a dangerous absolute to live in, in my mind, because there is a nuance there that we could be wrong.

28:19Dr. Muneeb Shah:The data is not yet there that says, yes, we have a body of data that says they're probably okay, but to absolutely say they're okay? And then on the flip side, there's no evidence from those studies that say that these are actually bad for the body, right? It's just like they do absorb more. And maybe there's some smaller studies that show different interactions with chemicals in our body that can theoretically be harmful. They've never been shown to cause harm in anybody, right? Because that's why they're still available on the market, right? And so you have these like two absolutes that are like not fully supported by evidence.

28:44Dr. Muneeb Shah:And then if you live in this world where you're always giving absolutes, you're going to be wrong sometimes, even if you had the best intentions. And then the more times you're wrong, the less people trust you. And I think a classic example of this was COVID. COVID was like every single person was coming out of speaking in absolutes about, you know, what to do and how to do it. And masks are doing this. And if you distance and you do this or, oh, you got to take some crazy medication that, you know, is going to save you. And everyone's just making all these and nobody knows anything yet. Right.

29:13Dr. Muneeb Shah:Like we're all like dealing with such limited information. Right. And the problem there, the problem with always being so certain and trying to be first with being certain is that now nobody trusts anybody anymore. And then you've lost trust for the medical community because everyone was making these assertions before they had the information. And so I think as a content creator or somebody who's a science educator online is that you have to resist the temptation to insert yourself in every conversation before all the information is out there and then be humble enough to go back and say, hey, either I was wrong.

29:41Dr. Muneeb Shah:You know, I assumed something and I was wrong or you need to put the nuance in there and say, hey, this is what I'm doing based on what I know. But I could be wrong because we don't fully know everything yet. And I think that's how you build trust people over time. Right. Because there's like a trust element. If no one trusts what you say, then you could talk all you want. So you have to earn people's trust and try to keep it. And I 100 % Dr. Maxfield and I always say this in videos like we're going to be wrong about things. We making our best estimation based on everything we've learned and we've done our best to cut through all of the science that's out there.

30:07Dr. Muneeb Shah:But new information will come out eventually that will make some of our old content look wrong. And it's a chance we take and we hope that people trust us enough for us to go back and fix some of those mistakes. And so I try not to speak in absolutes. I try not to be the first to react to anything. And I try to apologize when I'm wrong. And so that's how I try to position it. I love that. Well, thank you so much for being so like just honest and like being like real about it. You know, I honestly cannot say how valuable that is because even as somebody who has studied science my whole life, I go online to learn.

30:37I do it every day, you know, like I'm looking for experts every day to teach me about stuff. And there's so many times where I'm like, I don't understand why you're so adamant, you know, like about your take, like just, just be a little humble about it, you know, just, and so yeah, your message is so important. So thank you for sharing that. You You know, I think my last question for you is really about right now, especially dermatology, especially in skincare, everybody is trying to find their place. It feels like, you know, when I go online and I see all the people that are educating, they're trying to find their niche and their space.

31:06I would love for you to offer some words of wisdom here about growing as a young doctor. Like, say you're a young physician, you want to grow yourself on social media, you want to grow your presence, your influence. What are some words of wisdom they can take with them to really do it in a way that's meaningful?

31:21Dr. Muneeb Shah:Yeah, I'm glad you said that. Yeah, I think that's a really good question. A lot of young derms ask me this question, but I think the first thing I would say is like the skincare community in general is truly a community and it's made of lots of different contributing folks, right? You have dermatologists, we have our clinical expertise, we have our knowledge from what we see with patients, right? We have our feedback that we get from our patients and we have our knowledge that we have about understanding scientific literature, the best of our abilities, right? You have chemists who have a lot of knowledge about the chemical structure of ingredients.

31:49Dr. Muneeb Shah:They have some knowledge of toxicology. They have, you know, knowledge of, you know, how to maybe potentially formulate things. They're contributors to the conversation. You have skincare enthusiasts who try lots of products and give you their honest opinion. They're valuable too, right? Because they're going to tell you, are you going to like this product when you put it on your skin? Like they're going to say, hey, I have rosacea and I tried this and it really helped me, right? That's valuable too, right? So I feel like the skincare community, like everybody has a voice. Nobody's opinion is like more valid in my mind than anyone else's opinion.

32:18Dr. Muneeb Shah:It's just a piece of the puzzle, helping consumers try to find the ultimate type of things that are going to help them. Right. And so I have my lane and I try to stay in my lane. Right. But there's a community at large and I listen to everybody. Right. Like I, James Wells, YouTuber in the UK, love his recommendations. I think he's super honest. I think his recommendations are super solid. And when I watch his recommendations, I'm like, yeah, like I would try that. That's that looks like a really good take, you know. So ultimately, I think everyone like he's not an expert, never says to be an expert.

32:45Dr. Muneeb Shah:But like I find his his advice credible and I find his take on skincare products credible. There's lots of people like this, but that's just one example. And so I think community at large, everyone has a voice in it. And I just don't try to be something you're not, I think is one thing I'd say is like, don't try to be an expert when you're not an expert and don't try to be an enthusiast when you're not an enthusiast. I think that's important also, right? Because it's tempting as a dermatologist to take a brand deal that is a consumer product to insert your authority, the responsibility of the white coat into that brand deal when it's not something a derm would recommend, right?

33:16Dr. Muneeb Shah:So on the flip side, I don't think, I think if you're going to represent yourself as a derm online, take all the credibility and white coat and all the advantages that come with that, then you also have to take some of the restrictions that come with that too, which means you can't just be like saying things you like to do because, you know, you like to do them and they benefit you in the moment. So I think everyone kind of should try their best to stay in their lanes, but everyone is an important part of the conversation. And then I think on the young experts coming up in the world, I think always important to get new people and new voices in.

33:43Dr. Muneeb Shah:I think a lot of people see my platform, they say, oh, he's got 20 million followers. What am I going to say about dermatology that hasn't been said? You know, I've made a video on everything at this point, I feel. And so why should anyone else do this? And the reality is there's just lots of people who are not going to connect with me, right? There's 20 million people that follow me. They're all over the world, half are in the U.S. That means that in the U.S. alone, there are 340 million people that are unserviced by my content, right? And you might make a video that connects with them that I can't connect with them.

34:11Dr. Muneeb Shah:they don't look like me. They don't talk like me. They don't, they find that I'm a male. They'd rather listen to a female, for example. Right. So there's a value to amplifying expertise. And I think that everyone still has like a voice and like, just stay true to yourself, be unique in the way that you present things, be honest, be trustworthy and be consistent over time. And like, you'll find your community that loves your type of content. I still think there's huge opportunities in content creation. I think more experts need to be doing it because there's more misinformation than there is good information still.

34:39Dr. Muneeb Shah:And a lot of us who are experts, right, we follow a lot of other experts. So it feels like there's just so many experts online. But a lot of the consumers, they follow like one expert, maybe. So the reality is there's actually not enough experts. And so I think we need more. I think we need more nuance. I think we need different types. I don't think everyone needs to do the same type of content. You know, I feel like everyone falls into that. They're just doing the same thing. But like, I like different forms, like different forms of content, you know, different opinions on communicating, different ways of communicating.

35:07Dr. Muneeb Shah:Like that's how we're really going to break through. But I'm super excited. I mentor lots of young DERMs, especially, you know, I'm hopeful. I've seen this new wave of DERMs this last year, which I'm really excited about. You know, people are doing it in their own way. And I'm like, good, like, like I need to stop doing this and we need to like bring other people in is how I feel. I've been doing this six years, you know, I gotta, I gotta find something else to do at this point. No, but you've laid, you've laid a blueprint though, you know, like you've, you've really laid a blueprint. And I feel like so many people have learned so much from what you've created.

35:35And I love that. And I love that you teach. Like, that's awesome that you teach people how to get into the space because for so long, doctors are siloed. You know, it's like you go through your training and then you go into clinical medicine and that's all you do. And then this opens up so many avenues for like exploring so many fields you never even thought. If you're somebody who loves research and you don't even know you love research, you might discover it through making content, you know, who knows? So it's really, really neat that you, that you mentor people and that you are advocating for people to come out in a meaningful way.

36:04So really hats off to you for that.

36:05Dr. Muneeb Shah:Yeah. And I think your form of content, it's different, right? Like that's what's exciting to me is like when I see your videos online, you know, whether it's podcasts, but it's also like the short form stuff you've been doing lately. It's like a different way of communicating. It's a different form. It's a different perspective, right? You're talking about things other people aren't talking about. And so I think that that's so needed, right? Like this type of content is so needed and I appreciate anyone who does it and puts themselves out there. And to your point, I think I said earlier, like a lot of people see the opportunities like a brand deal, for example, what they don't see are the opportunities to consult, to develop, to change the way that the industry is moving, to be on committees.

36:40Dr. Muneeb Shah:Like I'm on committees with the American Academy of Dermatology where I help with policy and things like that. So there's just so many ways to engage once you start creating content beyond just creating content. So there's a whole nother layer of opportunities that I think is super exciting that no one ever sees. Yeah, absolutely. Well, thank you so much, Dr. Shaz. This was an incredible honor to host you again. And I would love to have you back if you ever have the time for it, because I always learn so much. And I know our audience really appreciates all of your insights. So thank you so much.

37:07Dr. Muneeb Shah:And thank you. And if you haven't checked out Remedy, you need to go check out Remedy. It's an amazing, amazing brand, like genuinely. So thank you so much. I appreciate that. It's good seeing you again. It was wonderful talking to you again. Thank you.

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Dermatologist Dr. Muneeb Shah returns to Skin Anarchy to break down what actually works in skincare, how GLP-1 medications affect the skin, the truth about trending ingredients, and how to spot credible science communication online. Below are the biggest questions answered in this episode.

Why did Dr. Muneeb Shah start his own skincare brand, Remedy?

After years of educating patients one at a time in clinic and then millions online, Dr. Shah saw a gap between how dermatologists actually treat skin and how most products are formulated. Remedy was built to combine multiple ingredients backed by evidence into single formulas, control ingredient sourcing, and remove emerging allergens as the science evolves. He frames it as the natural next chapter of his work: "Content was a hill at one point, and this is my new hill... building a brand that really becomes a legacy brand."

Why do so many skincare products feel identical?

Because many of them are. Dr. Shah explains that contract manufacturers offer white label stock formulas, so any brand with capital and distribution can put its label on an existing product and launch it. "It's not hard to launch products if you have the capital and the distribution network to support it," he says. "It's hard to launch good products." When an ingredient trends, brands rush to license the same stock formula, which is why the market floods with nearly identical products around every viral ingredient. Remedy's policy is to never use white label formulas and to start from a patient need rather than a trend.

Which skincare ingredients are actually backed by science?

According to Dr. Shah, the strongest evidence still sits with the tried and true ingredients: retinoids like retinol and tretinoin, alpha hydroxy acids like glycolic acid, select peptides but not all of them, ceramides for the skin barrier, niacinamide, and azelaic acid. His formulation philosophy anchors everything around these proven actives first, with marketing layered on only afterward, never the reverse. "The products have to be really great products that people will use forever, and they have to use ingredients that truly have the efficacy studies on them."

Is PDRN worth the hype?

Dr. Shah does not dismiss PDRN, noting it has real traction in East Asia, where dermatologists champion it, particularly in injectable form. "I'm not saying that doesn't have validity or evidence. Time will tell if this is something that stands the test of time." His caution is about how trends work: brands slap labels on stock PDRN formulas to ride the moment, and an ingredient trending is not the same as an ingredient being proven.

What does "next generation biomimetic surfactant technology" actually mean?

Usually nothing. Dr. Shah points out that "they're using the same surfactants everybody's got in their formulas... no one's inventing new surfactant technologies." Terms like this are marketing language designed to make a formula seem more advanced or worth a higher price, and even sophisticated consumers fall for it because there is not enough public knowledge about what these formula components actually do.

What do GLP-1 medications like Ozempic do to your skin?

Rapid weight loss from GLP-1 medications can outpace the skin's ability to retract, leading to crepiness, laxity, and undulations where fat volume was lost beneath otherwise healthy skin. Dr. Shah notes dermatologists saw similar effects with gastric bypass, but it was rare enough that it never needed a name. That is no longer the case: "Now that it's 12 percent of the population, we have to really contend with this."

What skincare should you use while on a GLP-1?

Dr. Shah recommends topicals that support collagen throughout the weight loss period: a retinoid such as retinol or tretinoin, an alpha hydroxy acid like glycolic acid to stimulate collagen production, and peptides with collagen evidence such as Matrixyl. "Anything that's gonna support your collagen and elasticity, maybe even like a copper peptide due to the elasticity element of the skin." These support the epidermis and dermis, but he is clear that topicals alone cannot compensate for significant fat and muscle volume loss underneath.

Can loose skin from GLP-1 weight loss be fixed?

Sometimes it resolves on its own if weight loss is gradual, but Dr. Shah notes many patients are started on doses that are too high. "When you lose 30 pounds in a month, there's really no skin treatment that can account for that loss of weight to make your skin snap back." For skin that does not recover, professional options include lasers, deeper chemical peels, and in some cases filler around bony structures to restore support. Slower weight loss gives the skin the best chance to keep up.

Why does nutrition matter so much on a GLP-1?

Because appetite drops sharply, patients risk falling short on protein and essential nutrients during a period of significant muscle and fat loss. "Anyone that's on a GLP really needs to optimize their nutrition while they're on it," Dr. Shah says, "because you're eating less, but what you're eating really then matters." He argues nutrition is a layer dermatologists need to be discussing with every GLP-1 patient, ideally in collaboration with nutritionists, gastroenterologists, and weight loss specialists rather than working in silos.

Do GLP-1s cause immune reactions?

"A lot of people actually develop antibodies to GLPs... your body recognizes it's a foreign invader and tries to neutralize it," Dr. Shah explains, which can produce injection site reactions, fevers, muscle aches, or symptoms that feel like the flu after injecting. This immunologic layer is rarely discussed, and he draws a parallel to PD-1 inhibitors in oncology, where he and Dr. Maxfield published an early case report of a patient developing type 1 diabetes from the immune system attacking the pancreas, a side effect now well documented in the literature.

Are chemical sunscreens safe?

Dr. Shah personally wears chemical sunscreens and prefers how they look on his skin, but he refuses to speak in absolutes in either direction. The data shows chemical filters absorb into the body more than previously thought, and no one yet knows whether that matters. At the same time, no study has shown actual harm in people, which is why they remain on the market. "To absolutely say these are completely safe and nothing bad will ever happen to you, that's a dangerous absolute to live in, in my mind."

Is longevity just antiaging rebranded?

Largely, yes, in Dr. Shah's view: "Longevity is really just similar to antiaging and to bodybuilding in the sense that it's a more extreme form of maximizing your health." He compares it to how looksmaxxing extended bodybuilding culture to the face, the same pursuit taken further. What has changed is access. Anyone can now watch a billionaire biohacker's routine on YouTube and order peptides from a telehealth site, which is exactly what makes this moment both exciting and precarious.

Are injectable peptides from telehealth sites regulated?

Not in the way most consumers assume. "I'm excited about the technology that's coming out as a scientist," Dr. Shah says. "As a doctor, I'm nervous about the access and lack of regulation." He predicts a regulatory correction, whether imposed by government or by the industry itself, after enough people experience negative consequences from unvetted peptides and unregulated med spas. He expects consumers will eventually start asking where products come from, seeking FDA approved options, and vetting the credentials of anyone treating them.

What is the danger of telehealth prescribing without integrated care?

Dr. Shah gives the example of someone with hair loss who researches online, requests minoxidil, finasteride, or spironolactone through a telehealth platform, and receives it at their door. "Turns out they have thyroid disease. No one asked the question... this element of integrated medicine is being completely removed." As telemedicine grows, conditions get treated at the surface while underlying diagnoses are missed entirely.

How do you know which skincare experts to trust online?

Dr. Shah's rule: be wary of anyone who speaks in absolutes. "When you speak in absolutes, most of the time you're gonna be wrong because there's not enough information out there." On polarizing topics like parabens, fragrance, or chemical sunscreens, both the "completely safe" and "completely toxic" camps overstate what the evidence supports. Trustworthy communicators caveat their claims, resist being first to react before information is complete, and publicly correct themselves when new data proves them wrong. He cites the erosion of trust in medicine during COVID as the cost of premature certainty.

What advice does Dr. Shah have for young dermatologists building a platform?

Stay in your lane and do not pretend to be something you are not: an expert should not act like an enthusiast, and an enthusiast should not claim expertise. Despite having over 20 million followers, he argues there are still not enough credible experts online, since most consumers follow only one, and new voices will connect with audiences he cannot reach. His advice: "Stay true to yourself, be unique in the way that you present things, be honest, be trustworthy, and be consistent over time, and you'll find your community that loves your type of content."

What opportunities exist beyond brand deals for doctors creating content?

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