In short
Lyme disease—what it is, how it spreads, why it’s often missed, prevention, and a controversy about whether it could be linked to bioweapons or climate change.
Guests/backgrounds
No episode guests. Hosts Josh Clark and Charles “Chuck” Bryant discuss the topic; they reference patient advocates and researchers (e.g., Judith Minch, Polly Murray, Willie (Willy) Burgdorfer).
Key claims
Lyme is caused by Borrelia burgdorferi and transmitted by tick bites, especially nymph-stage ticks that must be attached about 24–36+ hours. A hallmark rash (erythema migrans “bullseye”) appears in ~70–80% of cases. Diagnosis is difficult because early antibody tests can be negative and direct detection windows are brief; two-tier testing is recommended. There’s major debate over “post-treatment Lyme disease syndrome” and whether persistent symptoms reflect ongoing infection, immune effects, or autoimmune triggers.
Notable examples
Lyme’s naming after Lyme, Connecticut; 1970s Connecticut outbreak driven by moms’ advocacy; Utsi the Iceman (Lyme evidence) and a 5,300-year-old mummy; prevention tips (DEET, tick checks, shower/inspect); Congress legislation (Chris Smith’s Lyme bioweapon review and TIC Act funding).
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VOUnderstanding Lyme Disease
2:23 to 4:25
Learn the origins and misconceptions surrounding Lyme disease.
“This is Stuff You Should Know, the podcast.”
Statistics and Spread of Lyme Disease
4:25 to 5:41
Discussion on the increasing prevalence and geographical spread of Lyme disease.
“I think what got me was I heard about people saying like, no, Lyme disease, like people take it for granted, but it's actually some, this really mysterious illness.”
Chronic Lyme Disease and Misdiagnosis
5:41 to 7:00
Explore the challenges of diagnosing Lyme disease and chronic symptoms.
“Yeah, which is, I mean, there's a lot of debate over, the CDC calls Lyme disease endemic, which is a disease that has become like an ongoing part of an area or region.”
Transmission and Symptoms of Lyme Disease
7:00 to 9:07
Details on how Lyme disease is transmitted and its key symptoms.
“There's a big community out there of people that are like, why won't anyone listen to us?”
History and Recognition of Lyme Disease
9:07 to 12:27
Discover the historical context and scientific recognition of Lyme disease.
“where it just absolutely wreaks havoc on the human body.”
Global Impact of Lyme Disease
12:27 to 14:00
Understand the global increase in Lyme disease cases and its implications.
“only comes around in like maybe 70 to 80 % of cases.”
Introduction to Lyme Disease
14:00 to 14:47
Learn about the historical context and spread of Lyme disease.
“And there was a German physician named Alfred Buchwald who described this, that EM skin rash that we now call Lyme disease, about 130 years ago.”
The Lyme Disease Epidemic in Connecticut
17:56 to 28:00
Discover the early struggles and advocacy around Lyme disease in Connecticut.
“So Lime, Connecticut, something that's very old hat to you.”
Chronic Lyme Disease Debate
28:00 to 29:20
Explore the ongoing debate surrounding chronic Lyme disease and its symptoms.
“And because the medical establishment said, we got it, it's fine, these antibiotics cured it and didn't go deeper, that bacterial infection is allowed to fester and then present in worse ways later.”
Antibiotic Treatment Controversy
29:20 to 31:50
Learn about the controversy over antibiotic treatment durations for Lyme disease.
“And they think you're cured of the Lyme disease.”
Show all 19 chapters
Lyme Disease Statistics
31:50 to 32:45
Understand the growing statistics and impact of Lyme disease in the U.S.
“And this is something that is probably going to keep playing out, although it seems like it may be on its way out because of the epidemic proportions Lyme is taking now in the United States.”
Tick Transmission Insights
32:45 to 35:05
Discover how ticks transmit Lyme disease and their behavior in the wild.
“and every now and then I'm like, do I have Lyme disease?”
Preventing Lyme Disease
37:52 to 41:06
Get practical tips on preventing Lyme disease and checking for ticks.
“You know what phone calls are always super important to me are the phone calls that I have with my mom.”
Congress and Lyme Disease Research
41:06 to 42:01
Examine recent congressional actions related to Lyme disease research and bioweapons.
“I'm reading a lot about this in books and articles that we did research on Plum Island and other insects too, not just ticks, of turning them into bioweapons.”
The Origins of Lyme Disease: A Controversial Theory
42:01 to 43:54
Explore the theory that Lyme disease originated from government research gone awry.
“But in the book, Newby basically says the government at Fort Detrick, Maryland, and on Plum Island, New York, before it was turned into an animal disease research center, were doing...”
Debating the Biological Weapon Hypothesis
43:54 to 46:08
Discuss whether Lyme disease was an accidentally created biological weapon.
“and, you know, it's really close to this ground zero of where the tick epidemic began, you put two and two together.”
Climate Change and the Rise of Lyme Disease
46:08 to 48:35
Learn how climate change is linked to the increasing prevalence of Lyme disease.
“No, and then again, people who subscribe to this conspiracy theory say, well, they can't all be winners, but maybe it was just something they were experimenting with and it wasn't very good.”
Environmental Factors Affecting Tick Populations
48:35 to 51:40
Discover how environmental changes and deer populations contribute to tick outbreaks.
“And there's this really great article on Aeon, which is a great website, by Mary Beth Pfeiffer, spells it like Michelle Pfeiffer with a P, called Ticks Rising.”
Advocacy and Awareness in Lyme Disease Research
51:40 to 52:18
Discuss the importance of advocacy in Lyme disease research and treatment.
“Yeah, advocate for yourself still, people.”
Transcript
Automatic transcript. May contain errors.0:00Josh Clark:This is an iHeart Podcast. Guaranteed human. With no fees or minimums on checking accounts, it's no wonder the Capital One bank guy is so passionate about banking with Capital One. If he were here, he wouldn't just tell you about no fees or minimums. He'd also talk about how most Capital One cafes are open seven days a week to assist with your banking needs. Yep, even on weekends. It's pretty much all he talks about, in a good way. What's in your wallet? Terms apply. See CapitalOne.com slash bank. Capital One N-A member FDIC. You ever been to the pharmacy counter and your mind goes blank when the pharmacist asks?
0:33Josh Clark:Any questions? Well, that's why you need to listen to Beyond the Script from CBS Pharmacy and iHeart Media. Hosted by Dr. Jake Goodman, each episode features real conversations with CBS pharmacists, the health experts you see most, breaking down the questions you wish you'd asked, from which meds may not mix well to what vaccines you need before a big trip. They're going to bust the myths, decode trends, and share practical advice you can actually use. Listen to Beyond the Script on the iHeartRadio app, Apple Podcasts, or wherever you get your podcasts. This episode is brought to you by Audi. We all know that feeling, a change of plans, a new opportunity.
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1:55Chuck Bryant:of people in Connecticut, and then they finally figured out it was coming from ticks. But the mystery wasn't over because people started developing chronic Lyme, and at first, the medical community didn't believe they had any disease whatsoever. They thought it was all in their heads. Well, they were wrong. You can find out about all this and more in this episode on Lyme disease. Enjoy.
2:22Josh Clark:Welcome to Stuff You Should Know, a production of iHeartRadio.
2:32Chuck Bryant:Hey, and welcome to the podcast. I'm Josh Clark. There's Charles W. Chuck Bryant. And there's Jerry over there. This is Stuff You Should Know, the podcast. And Chuck, I have a question for you. Yes. You know what ticks me off? Lyme disease. I'm so mad at you. Blame Yumi for that one. She's like, you should say this. And I said, you know what, dear? I should totally say that.
3:01Josh Clark:Yeah, this is sort of a follow-up to our July 27, 2010 episode, Why Ticks Suck, which is sort of a legendary episode because we falsely promised to send people T-shirts if they made it all the way through the episode.
3:17Chuck Bryant:That's right.
3:18Josh Clark:We were just kidding, but we still get those requests of where's my shirt.
3:21Chuck Bryant:Yes, that's hilarious. I forgot about that. We get sued today.
3:26Josh Clark:Yeah, probably so. Also want to point out and shout out our former website, HowStuffWorks.com, because a couple of the articles that we used for much of this episode is from the old HSW website.
3:40Chuck Bryant:Nice. They're holding it down over there.
3:43Josh Clark:They're holding it down, and this is some good stuff.
3:45Chuck Bryant:Yeah, so we're talking today about Lyme disease in particular.
3:49Josh Clark:Not Lyme's.
3:51Chuck Bryant:No, we should say it's capital L-Y-M-E disease. And the reason it's called that is because it's named after a town, which is one of three towns where the initial outbreak of Lyme disease that led to this bacterial infection, persistent bacterial infection, was first described medically.
4:11Josh Clark:Yeah, one of the facts of the show, I think. Oh, yeah? Sure. Who knew it was named after a town? Lyme, Connecticut. I knew. Did you know that before this? Sure. Did we cover that and why ticks suck? I don't think so. All right. Well, you're smarter than me then.
4:24Chuck Bryant:No, it's not that. I think what got me was I heard about people saying like, no, Lyme disease, like people take it for granted, but it's actually some, this really mysterious illness. And I'm like, what are you talking about? So I think I looked into this years back and that's when I found out.
4:39Josh Clark:All right. That was all. So we're equally smart.
4:41Chuck Bryant:Right. Exactly. I'm not smarter than you.
4:43Josh Clark:And what is smarts? It's just like someone happens to know one thing, someone else knows another. Sure. I say they cancel out. We're all smart.
4:52Chuck Bryant:There you go. I'm glad you pulled that out because I would have been like, what is smarts? I couldn't have come up with the definition. So Lyme disease, we'll go ahead and hit you with a couple of stats here.
5:05Josh Clark:Lyme disease in the United States has more than doubled since 1997.
5:09Chuck Bryant:That's astounding.
5:10Josh Clark:It is. And it has spread too. It used to be very much localized in kind of the northeast, sort of mid-Atlantic areas, some in the south. But now you can get Lyme disease in, I believe, the entire lower 48. Is that correct?
5:26Chuck Bryant:There are cases in all 48 states. Supposedly half of the counties in the United States now are considered at high risk for Lyme disease. And, like, all of this happened just in the last, like, 20 or so years. Yeah. Yeah, which is, I mean, there's a lot of debate over, the CDC calls Lyme disease endemic, which is a disease that has become like an ongoing part of an area or region. And some other people are saying, guys, what we're talking about here is an epidemic. This is an epidemic and you should start calling it that because it will kind of raise the alarm to the next level or two where it should be because this is a very alarming spread of disease that we're seeing.
6:11Chuck Bryant:right now. Lyme disease is the number one vector-borne disease in the United States. It's way more prevalent than things like West Nile or chikungunya or anything like that, but it's still kind of treated as like up there in the northeastern U.S. thing, and that's just not the case. It's spread in every direction except east because it hit the Atlantic, but everywhere else where it can spread into the interior of the United States and up into Canada, it's starting to.
6:39Josh Clark:Yeah. And there's also a history continuing to this day, even, where Lyme disease can be overlooked, misdiagnosed, not taken as seriously by your doctor as it should be. Yeah. Including what we'll get to later on, something called post-treatment Lyme disease syndrome. And it's all very frustrating if you have been an individual that has had Lyme disease.
7:06Chuck Bryant:Yeah.
7:06Josh Clark:There's a big community out there of people that are like, why won't anyone listen to us? Why won't our doctors take us seriously? And what do we have to do here? Like, do we have to start dropping dead?
7:16Chuck Bryant:Yeah, there's a tremendous amount of frustration in that community because there's a sentiment among the medical establishment that, you know, hey man. Take some antibiotics, you'll be fine. Exactly. It's easy to cure Lyme disease. Here's some antibiotics. You still have persistent symptoms. Those are probably in your head. We're not going to say they're in your head, but they're in your head. And the people who are experiencing these symptoms are like, no, my life has been derailed by these symptoms and you guys aren't doing anything about it.
7:44Josh Clark:It's frustrating. I know there's a lot of people out there that are pretty stoked right now to be hearing this. Yeah, for sure. We're advocating for you guys.
7:52Chuck Bryant:Sure.
7:53Josh Clark:Not patting myself on the back, although I am literally patting myself.
7:55Chuck Bryant:I feel like I see you, Chuck. That elbow is sticking out pretty far.
8:00Josh Clark:So Lyme disease is a disease. It's an infection. caused by the bacterium Borrelia burgdorferi. Wow. Burgdorferi. Burgdorferi.
8:13Chuck Bryant:We're going to get you an apron and call you the word butcher.
8:17Josh Clark:Burgdorferi. Mork, mork, mork. And we'll get to why it's called that in a bit.
8:21Chuck Bryant:Okay.
8:22Josh Clark:But if you haven't caught on by now, it is transmitted through tick bites.
Read the full transcript
8:25Chuck Bryant:Right. So a tick, and in particular a nymph stage of a tick, which is a young adult or juvenile tick, will transmit this bacteria, the Borrelia burgdorferi, into a human. And the reason we usually get it from nymphs, Chuck, is because an adult tick doesn't find humans particularly appetizing. But a nymph tick will because they're stupid. They don't know anything yet. So as they're feeding on us, after somewhere maybe around 24 to 36 hours of feeding, this infected tick that has this bacteria in it, the bacteria will make its way from the mid-gut to the tick saliva, and the tick transmits it into the human bloodstream, where it just absolutely wreaks havoc on the human body.
9:13Josh Clark:Yeah, and you said something really key there, 24, 36, 48 hours later. Really, really important. They have to be attached to you for that long, sometimes even longer, to transmit this bacterium. So if you find a tick on you and you get it off, you don't need to sweat Lyme disease.
9:30Chuck Bryant:No. If you get it off in due time. Right, exactly. If you see it still crawling on you, it's unattached, don't worry about it at all. But when it is attached and when it has transmitted the bacteria, what it's transmitted, this B. burgdorferi, is really amazing at its job, which is infecting you, giving you a bacterial infection. It has figured out how to zoom through the bloodstream, but then also take itself out of the bloodstream by latching onto the walls of your blood vessels.
10:02Josh Clark:Yeah, this was crazy about this cellular stuff, that once it's attached to a cell, they said it's like a slinky. It doesn't let go. It just like basically reaches out and grabs the next cell without letting go of the previous cell and just sort of walks end over end, never unattaching itself.
10:21Chuck Bryant:Right, exactly. So as it's moving along, it's not going to get kind of washed away in the extracellular matrix. It's stuck to the cell if it wants to be stuck to the cell. It can do the same thing to the blood vessel walls to pull itself out of the bloodstream and then go attack specific parts of the body. So it's really good at hanging on. That's one thing that makes it kind of pernicious. Like ticks. Exactly. It's basically, yeah, it's like the bacteria version of a tick. I didn't think about that. And then another thing it does, Chuck, I think this is really, really recent research, it can actually change its protein expression at a much faster rate than the normal mutation rate for bacteria.
11:04Chuck Bryant:Something like 15 times faster.
11:06Josh Clark:Yeah, what that does is that just makes it really hard for our human immune system to catch up to it.
11:12Chuck Bryant:Right, because our immune system will produce antibodies based on the initial infection, But by the time the antibodies come around, the bacteria may have changed itself so that the antibodies won't recognize it. They'll just go right past it because it doesn't fit the description that the antibodies have.
11:32Josh Clark:That's right. And you'll know that something bad is happening, first of all, if you find that tick. But if you get headaches, fever, fatigue is a huge, huge symptom.
11:43Chuck Bryant:Yeah.
11:43Josh Clark:But the real telltale is what's called EM. It's an expanding skin rash called erythema migrans. And it's like that circular pattern. And I know we did talk about this on the Ticks episode, but it's a circular pattern with what looks like a bullseye in the center of it.
12:01Chuck Bryant:Yes. And you can take off your butcher's apron now because you just, that was beautiful. Put on your chef's hat. You're sweating over there. Yeah. So that particular rash, that bullseye rash that is like just an absolute telltale sign that you have a Lyme borreolus, a Lyme borreoliosis infection, that only comes around in like maybe 70 to 80 % of cases. I think if every person got that rash, we would not have this problem with Lyme disease because it would be caught very quickly because you get that within usually about a week or less of getting infected. But it doesn't come up in all cases. And with some of those other symptoms, like you said, like weakness, headaches, flu-like symptoms, like those could be a lot of different other things, joint pain.
12:58Chuck Bryant:And so the Lyme disease infection goes undiagnosed or misdiagnosed in a lot of cases or did for many, many years. It's just now that they're starting to kind of recognize it or suspect Lyme when otherwise they might not have.
13:14Josh Clark:Yeah, I mean literally hundreds of things can have the same symptoms as Lyme disease. So Lyme's been around for a long time. We'll talk about the history here in a minute as far as the 1970s go. and official recognition, but it's been around. I believe Yale School of Public Health find the bacterium in ancient North America, like 60 ,000 years old, before the arrival of humans. They have an autopsy of a 5 ,300-year-old mummy that had Lyme disease.
13:48Chuck Bryant:Yeah, you know, Utsi the Iceman. Remember him? I remember Utsi. Yeah, I was disappointed that they referred to him as a 5 ,300-year-old mummy. It's like, no, it's Utsi. The ice cream, everybody knows him. Give him his name. But he had Lyme disease.
14:01Josh Clark:He did. And there was a German physician named Alfred Buchwald who described this, that EM skin rash that we now call Lyme disease, about 130 years ago.
14:13Chuck Bryant:Right. So Lyme disease has been around a while, but we are just now seeing a huge, again, an epidemic of it. And a massive spread of it, not just in North America, but there's also two other kinds of ticks that transmit two other kinds of Lyme-causing bacteria in Europe and Asia. And in all three places, North America, Europe, and parts of Asia, the incidence of Lyme disease is picking up at an alarming pace.
14:44Josh Clark:I think we should slow down our pace, take a break.
14:47Chuck Bryant:Okay, all right.
14:47Josh Clark:We'll come back and we'll talk about Lyme, Connecticut, right after this. Da-da-da-da-da-da-da-da-da-da-da. Stuff you should know.
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17:55Josh Clark:All right. So Lime, Connecticut, something that's very old hat to you. Right. Brand new to me. I've known about it for years. Lime, old Lime, and what was the third town? I don't remember. No, let's just call it New Lime. It was not New Lime. They're going to be so mad.
18:11Chuck Bryant:Their high school football team is going to go berserk. On old Lyme this year?
18:15Josh Clark:In the 1970s, though, there were a group of children and adults in these towns in Connecticut that were having all these weird symptoms. Swollen knees, skin rashes, headaches, all this severe fatigue. And it's bad enough these days, but in the early 1970s, doctors were definitely, did not have this on the radar and were very dismissive of what was going on in these towns. And if it were not for the work of Judith Minch and Polly Murray, two just regular moms, although Polly Murray did work for the World Health Organization for a while, they were advocates. They were patient advocates because their families were getting sick and no one would listen.
18:57Josh Clark:And they were like, someone's got to do something. Something's going on here. And these doctors are not being any help. Right. And it was a big deal. Polly Murray ended up writing a book. She made it sort of her life's work in 1996, a book called The Widening Circle. And because of sort of the persistent sexism in science, they were largely discounted, even though they had a list of 37 individuals. They researched on their own, contacted scientists. We just really need to shout them out. Polly Murray died just about a month ago at the age of 85.
19:32Chuck Bryant:Oh, is that right?
19:32Josh Clark:Yeah.
19:33Chuck Bryant:Yeah, she was a persistent cuss, as they call them up in the Yankee states.
19:37Josh Clark:That's right.
19:37Chuck Bryant:So on the one hand, yes, from everything I've read and all the impressions I have, they were very much dismissed and it was very much sexist. And also, I think, because they weren't doctors. But on the other hand, the doctors who were being presented with these cases were like, I have no idea what this is, so let's just pretend it's not real. But luckily, those two women in the groups that they established, they went on and they contacted Yale Medical School. They contacted the state and they really kind of put this on the map. They said there is a mysterious epidemic that's going on where you have a lot of kids who suddenly have juvenile arthritis out of nowhere.
20:17Chuck Bryant:What are you guys going to do about it? And because of their agitation, this mystery made its way to the desk or I guess the microscope of a guy named Willie Bergdorfer. And he was at the time the world's foremost authority on what's called Rocky Mountain spotted fever. which is another tick-borne bacterial infection.
20:40Josh Clark:I remember that when I was a kid. That was a big news item. It was. A scary one.
20:44Chuck Bryant:He was working out in Colorado, and Colorado was ground zero for Rocky Mountain spotted fever for a while, which is, yeah, you do not want to have that. It's a really bad bacterial infection. But by this time, they had done, thanks to the legwork done by the moms and the patient advocate groups in Lyme, Connecticut, it, it had been pretty well established that the common thread between all these people, besides where they lived, and by the way, it was Chuck Lime, Old Lime, and East Haddam. Sorry, East Haddam. Aside from the fact that they all lived in the same region, was that all of them, or almost all of them, were called being bitten by a tick.
21:24Chuck Bryant:And a lot of them had a mysterious rash right before the symptoms presented. So it came to this guy, Willie the Bergdorfer's microscope because they had said, there's something in the ticks here that is creating this disease that we haven't encountered before.
21:39Josh Clark:That's right. And he had already discovered this bacterium called, how do you pronounce that? Spirochet? Spirochete. Spirochete.
21:51Chuck Bryant:But a spirochete is a type of bacteria. Spirochet.
21:55Josh Clark:That's what I know. Give me the apron.
21:57Chuck Bryant:There you go.
21:58Josh Clark:All right.
22:00Chuck Bryant:Spirochet. You just made me think of the older brother Chet in Weird Science.
22:04Josh Clark:Now go make yourself one, buttwad.
22:08Chuck Bryant:Man, that guy had some good quotes.
22:10Josh Clark:Oh, yeah. R.I.P. What? Bill Paxton. When? He died a couple years ago. Very sad. Are you sure? I'm positive.
22:19Chuck Bryant:You're thinking of Bill Pullman.
22:21Josh Clark:No, Bill Paxton died. It was so sad because I had just listened to his Marc Maron interview, and he was like, after that episode, I wanted nothing more than to be Bill Paxton's friend and neighbor. Oh, neat. He just sounded like the best guy and best family man, and he passed away way too early.
22:37Chuck Bryant:Yeah, really. I did not know about that. I saw Frailty not too many weeks ago. It's still pretty good.
22:43Josh Clark:Was it the first viewing?
22:45Chuck Bryant:No, no, no. I'd seen it before, but years ago. Yeah, man, great movie. Yeah, but he wrote and, I believe, directed and starred in it.
22:52Josh Clark:Yeah, it was so good. And I love a good Powers Booth casting call.
22:55Chuck Bryant:For sure. It was unusual and surprising, but it was perfect.
23:00Josh Clark:Very good underrated film. Where are we?
23:03Chuck Bryant:Oh, yeah. We were talking about Rocky Mountain spotted fever, Willie Bergdorfer identifying the spirochete that was causing Lyme disease.
23:12Josh Clark:Spirochete, right.
23:13Chuck Bryant:Spirochet. What a dum-dum.
23:16Josh Clark:No, no.
23:17Chuck Bryant:Remember we established we're all smart.
23:19Josh Clark:Yeah, so he discovered this parakeet. and he was honored by this discovery and naming that thing after himself. That's why it has that interesting name.
23:33Chuck Bryant:I get the impression he didn't name it after himself. They named it after him. No, so they honored him. No, go on. Yeah. Okay. But there's a big difference between him saying this thing's called the Bergdorfere bacteria and somebody saying we're going to name this after you.
23:48Josh Clark:No, I totally agree.
23:50Chuck Bryant:Okay. So Bergdorfer, he figures out what is the basis of Lyme disease, which is great. That's an enormous breakthrough. It establishes that, yes, it is its own thing. It's its own disease. And because it was a bacteria, it's a spirochete, which, again, it's kind of a snake-like shaped bacteria, a specific kind that walks like a slinky. Because it was a bacterial infection, the medical establishment said, oh, we got this here. Take some antibiotics. And over, you know, the course of several years, starting in, I think the 90s is when they really started to say, okay, we can cure Lyme disease, especially if we catch it early on, by a two - to four-week round of antibiotics.
24:36Chuck Bryant:Here you go. And they said, case closed. We're the medical establishment. Let's go have a party for ourselves.
24:43Josh Clark:Yeah, and here's the thing. Like, many times that can take care of the problem.
24:48Chuck Bryant:Mm-hmm.
24:49Josh Clark:So it's not like they were just lazy and not doing their work. But I think they closed the book a little too soon, and a lot of people do, because that round of oral antibiotics, if you catch it early, it can really work. And I think they say, what, like nine times out of ten, if you catch it early, then that will work.
25:10Chuck Bryant:Right. They're so persistent with that assertion that if you find a tick on yourself and you live in an area where Lyme disease is known to thrive, if you can't say how long that tick's been on you, they're probably just going to give you that round of antibiotics prophylactically. Yeah. And again, like you said, in a lot of cases, and I believe from what I've read, the vast majority of cases in early stage Lyme disease, that round of antibiotics should work.
25:41Josh Clark:Yeah, and they say that if you, and this is from the American Lyme Disease Foundation, quote, if you live in an endemic area, have symptoms consistent with early Lyme disease and suspect recent exposure to a tick, present your suspicion to your doctor so that he or she may make a more informed diagnosis.
26:00Chuck Bryant:Right, show up to your doctor and say, Madam, sir, I would love to present my suspicions to you. Please sit down.
26:07Josh Clark:Well, they're saying you still sort of need to be your own advocate. Because it is so hard to diagnose still. Because if you're going on symptoms alone, like we said, there are hundreds of things that share those symptoms. And Lyme disease may not be the first thing they think of. That's a huge problem with Lyme disease.
26:24Chuck Bryant:Another huge problem is that the test we use to test for Lyme disease doesn't actually test for the B. burgdorferi bacteria. Right. It tests for the antibodies that should be present in your bloodstream if you have a bacterial infection. Not even specific to that one, but a bacterial infection. The problem is it takes days, if not maybe a week or two, before your body mounts an effective immune response against this infection. So if you find a tick and they give you a test, say, within the first couple days, it's going to come back negative. Even though you very much have a burgdorferi infection, it's going to come back negative because the antibodies haven't been created yet.
27:07Chuck Bryant:The other part of the problem is even if you take a blood test that tests directly for the Bergdorfere bacterium, it moves out of the bloodstream really easily and within several days. So there's a very brief window of time where you can directly test for the Bergdorfere bacteria and find it in a simple blood test.
27:29Josh Clark:Yeah, you can also get false positives. and they're advocating now for two-tiered testing for confirmation of the diagnosis. So if you get that first positive test, sometimes now you'll get a different test, a Western blot test that's going to really get more specific to that antibody, not just the general antibodies.
27:49Chuck Bryant:Right. So part of the other problem is the reason a lot of patient activists and patient advocate groups say, no, doctors, you're wrong. Like this is not good enough. is that there's a sneaking suspicion among people who have what's called chronic Lyme or post-treatment Lyme disease syndrome is that the round of antibiotics, the two - to four-week round of antibiotics that seemingly cured the Lyme disease symptoms that you had actually failed to fully knock out the bacteria that created this infection, that created this Lyme disease in the first place, that it just burrowed further into your body.
28:30Chuck Bryant:And because the medical establishment said, we got it, it's fine, these antibiotics cured it and didn't go deeper, that bacterial infection is allowed to fester and then present in worse ways later.
28:44Josh Clark:Yeah, and it's a really big deal because, you know, what will happen is they'll say, you're cured. We gave these antibiotics. They worked. but weeks and months and even years later when people have persistent fatigue and muscle aches and headaches and, you know, like your knee joints hurt, they said like a brain fog can happen. And these are all things that are, I don't want to say generic, but if you walk into your doctor and say I feel like I'm fuzzy and I have a brain fog and I get headaches and I'm tired, it's sort of a wide, it's hard to pinpoint what's going on. Sure. And they think you're cured of the Lyme disease.
29:24So that's where some of the more dismissive, at least from the Lyme disease community, they're saying, like, I have this chronic issue.
29:31Josh Clark:And they're saying, but no, there's no such thing as a chronic issue.
29:35Chuck Bryant:Right. Well, they're also saying, like, look, we gave you a test for Lyme disease and you came back negative. Right. You know, we know you had it before. We tested you. We came back positive. We treated with antibiotics. Now we've tested you again and it's coming back negative. if you don't have Lyme disease anymore. So there's a huge debate whether the antibiotic course is not enough and that the Lyme disease is persisting elsewhere in the body and that maybe it's changed its form so that it won't show up on the tests like it should or there's remnants of it. I saw one article that suggested that the cell wall from the spirochete, the Bergdorf-ry spirochete, can remain even after the thing's dead and persist in like joint tissue and cause an immune response there, which would explain this long-term arthritis as like a post-treatment Lyme disease syndrome symptom.
30:30Chuck Bryant:Or is it that it converts into an entirely different disease like an autoimmune disorder?
30:37Josh Clark:Yeah, some people think that it could trigger an autoimmune response. And the infection's gone, and this is what's happening later on is you have this autoimmune response It can lead to other things like rheumatic heart disease. I think we did. We cover Guillain-Barre syndrome or just talk about it in different episodes.
30:58Chuck Bryant:We've talked about it. And I think if I remember correctly, it's Guillain-Barre.
31:02Josh Clark:Guillain-Barre. Give me the apron.
31:04Chuck Bryant:I'm pretty sure. Yeah. We could both be wearing the apron for this one, though.
31:08Josh Clark:Well, we'll split it up. I get the lower half.
31:10Chuck Bryant:All right. I get the top half.
31:12Josh Clark:I'm Porky Pig in it. All right. I'm going to just cover my bits down there. but regardless of what's happening what people know is that they don't feel right and it's extremely frustrating to feel these symptoms months and years later and not be taken seriously in a doctor's office
31:31Chuck Bryant:yeah so a lot of people are saying this course of antibiotics shouldn't be two to four weeks it should be many months because you really need to get all of the spirochete out of there or else it's going to persist and you're going to have big problems And then the medical establishment is saying like this, what you're talking about doesn't even exist. So there's a lot of frustration, like you're saying, a big disconnect. And this is something that is probably going to keep playing out, although it seems like it may be on its way out because of the epidemic proportions Lyme is taking now in the United States.
32:04Josh Clark:Yeah, I mean, the statistics are mounting up such that it can't be ignored any longer. Not that it was ignored, but, you know, that's probably a harsh statement. But it's being taken way more seriously now.
32:14Chuck Bryant:Yeah, so something like there's an expectation that there's going to be something like 300 ,000 to 400 ,000 new cases of Lyme disease in the United States alone. And that 10 % to 20 % of those patients will end up with chronic Lyme disease.
32:33Josh Clark:Yeah, I mean, I spent a fair amount of time hiking around the woods with my dogs and have pulled plenty of ticks off of them and plenty of ticks off of myself. and I have fatigue a lot because I have a four-year-old and every now and then I'm like, do I have Lyme disease? Well, probably not, and here's why. Well, I've never had the bullseye, first of all.
32:52Chuck Bryant:Okay, that's a big one, but also the ticks you pull off of your dog, those are dog ticks. They do not transmit Lyme. It's specifically the black-legged tick, which is a type of deer tick.
33:04Josh Clark:Well, but here's the thing. There are plenty of deer ticks in the woods. Are you saying that they would not latch onto a dog and they'd be like, ooh, no? I don't know. I don't know. Because there's deer ticks all over the woods.
33:16Chuck Bryant:Sure, there definitely are. I don't know if deer ticks will latch onto a dog. It's entirely possible they won't since there's such a differentiation between dog ticks and deer ticks. But I do know that dog ticks don't transmit Lyme.
33:30Josh Clark:Well, I think we should talk about my favorite thing from the ticks episode, and this is one I will lay on people from time to time, is remember how ticks attach themselves? Sure. They just hang out on blades of grass and things and just snap their little claws constantly, just waiting for something to pass by that they can latch onto.
33:50Chuck Bryant:Right. They sense the CO2 of the mammal that's walking past them. So interesting. And Chuck, one thing I read is that somehow the Lyme-infected ticks, because they're infected themselves, Lyme resides in like small mammals and rodents as a reservoir. They're infected, but they don't have symptoms. Ticks get infected with this stuff and they're just passing it along. It's not like they're the ultimate source of Lyme disease. No, ticks are misunderstood. They're really great. Right. But from what I saw, the ticks that are infected with the Lyme bacteria are actually better at finding hosts than non-infected ticks.
34:31Chuck Bryant:Like it somehow enables them to be better parasites.
34:35Josh Clark:That's amazing.
34:36Chuck Bryant:Isn't that interesting?
34:37Josh Clark:Yeah, that sounds familiar. Did we cover that or do I just know that because I'm smart?
34:41Chuck Bryant:I don't remember. But I do, I remember you talking about in the ticks episode about how they wave their arms in the air waiting for somebody to pass by. And I remember one of our listeners made some art of that. We got to find it.
34:54Josh Clark:That's right. And from snapping their little fingers on a blade of grass to my dog's butt to my scrotum, it's quite a ride. It's a wild ride. And then to Emily eventually plucking that thing out for me. That's nice. That's what marriage is all about, folks.
35:11Chuck Bryant:Yeah. You just have your forearm thrust across your eyes. You're like, get it out, get it out.
35:17Josh Clark:So let's take another break. Okay. We'll talk a little bit about prevention and then a little bit about some very recent interesting wacky things going on in Congress about Lyme disease as a bioweapon. Okay.
35:34Chuck Bryant:Okay. Da-da-da-da-da, da-da-da-da, stuff you should know.
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38:50Chuck Bryant:Okay, Chuck, you talked about prevention. How do you keep from having to have a tick pulled from your crotch?
38:55Josh Clark:Don't ever go into Mother Nature. Just stay in your mid-century modern home with tiled floors and don't go into the woods.
39:04Chuck Bryant:Sounds delicious.
39:05Josh Clark:No, I love the woods. You love the woods, right?
39:08Chuck Bryant:Yeah. Yeah? I love watching the woods on television.
39:12Josh Clark:From your mid-century house?
39:13Chuck Bryant:No, I do. I love the woods myself.
39:16Josh Clark:Yeah, I'm just kidding. Get in the woods, but they recommend things like DEET. I don't use that stuff. on my own body. But some people will say, put that all over your body and put it on your clothes and put it on your socks and shoes.
39:32Chuck Bryant:Just walk around spraying a cloud of it around you constantly while you're in the woods.
39:36Josh Clark:What I do is I just check for ticks.
39:38Chuck Bryant:Yeah, a good thing to do, seriously, it looks super dorky, but what do you care is to tuck your pant legs into your socks.
39:45Josh Clark:Yeah, sure.
39:47Chuck Bryant:And then when you come out, like wear light colors too because you can see the ticks a lot more easily. And then when you come out of the woods, take your clothes off and take a shower as soon as you can and just inspect yourself. Inspect your groin, your armpits, your scalp. Part of the problem with Lyme disease, though, is remember you get it from ticks in the nymph stage, which are really, really small. So you've got to check really, really well to see if you have that tick on you. Yeah, and just while you're at it, take off the adult ticks as well. Yeah. Don't leave them. Yeah, don't just leave those on.
40:25Josh Clark:And check your dogs, you know. You check your dogs under their haunches, like on the armpit of their legs, whatever that's called, their leg pits. Check behind their ears. Check under their collars. Because ticks are trying to, you know, they're not going to hang out just like on the top of their back. They may start there, but they're going to try and find a place that's dark and warm and out of view.
40:48Chuck Bryant:Yeah, I don't mean to say you can't get Lyme disease from an adult, Chuck. It's just that the nymphs are far more likely to feed on a human than an adult is. But a Lyme-infected adult tick will transmit Lyme to you too, for sure.
41:03Josh Clark:Yeah, a very important distinction.
41:05Chuck Bryant:Yeah.
41:05Josh Clark:So now we move on to the U.S. Congress.
41:08Chuck Bryant:Yeah.
41:08Josh Clark:Very recently, about a month ago.
41:11Chuck Bryant:End of July, I think.
41:12Josh Clark:Yeah, there was a U.S. House rep named Chris Smith, a Republican out of New Jersey, who introduced legislation that said, hey, Department of Defense, you should review these claims that I'm seeing that our own Pentagon researched using ticks to spread Lyme disease as a bioweapon in the mid-20th century. I'm reading a lot about this in books and articles that we did research on Plum Island and other insects too, not just ticks, of turning them into bioweapons. And this thing passed. And a lot of this comes from a book written by Chris Newby called Bitten, colon, The Secret History of Lyme Disease and Biological Weapons.
41:55Chuck Bryant:And this book, like, I think Chris Smith, the representative from New Jersey, said, like, this book really inspired me to take up this legislation. But in the book, Newby basically says the government at Fort Detrick, Maryland, and on Plum Island, New York, before it was turned into an animal disease research center, were doing...
42:16Josh Clark:It was an insect disease research center before that, I guess.
42:19Chuck Bryant:They were looking into... Well, they definitely were doing biowarfare research there.
42:26Josh Clark:Early 1950s?
42:28Chuck Bryant:Mm-hmm.
42:28Josh Clark:Yeah.
42:28Chuck Bryant:And then Fort Detrick for however long, if they're not still doing it now. But they were apparently looking into ticks as delivery systems for biological weapons. I couldn't find that that is actually verified, but I find that highly believable. But what Newby is saying is they were doing that research and then the way we got Lyme disease is whatever research they were coming up with escaped, say a tick attached to a bird that flew off of Plum Island and landed in the area around Lyme, Connecticut. And these ticks got off and they started to breed and they became endemic in this area, and that's where Lyme disease came from.
43:11Chuck Bryant:There was actually a biological weapon that was produced and then inadvertently, probably not purposefully, released into the larger population in the Northeast.
43:22Josh Clark:Yeah, so here's my question. I haven't read the book, but are they saying that we created Lyme disease or that we just weaponized it? Because those are two very different things.
43:36Chuck Bryant:Yeah, I don't know what she's saying either. And I think she stops short of saying that, but that it's implied that if you put two and two together, the government was looking into biological warfare and they were talking about, you know, using ticks at some point. and, you know, it's really close to this ground zero of where the tick epidemic began, you put two and two together. That's the impression I have is that she didn't actually come out and say it, but that she lets the readers surmise for themselves, which is the problem.
44:09Josh Clark:Well, I mean, that's very easy to disprove if she's actually claiming that they created Lyme disease because we just got through saying it was in, who was the mummy? Ootsie. It was in Ootsie 5 ,300 years ago. Over in the Alps. Well, true. But also in the United States, I mean, it came around in the—we first discovered it in the 1970s in, like, several different places. It wasn't just Lime, Connecticut. They found it in California. Right. And you can't just—it doesn't add up that it would be popping up in all these random places if it escaped from Long Island Sound in 1953.
44:47Chuck Bryant:Right, which I think somebody who's subscribed to this conspiracy theory, and it's very much what it is as a conspiracy theory, that, well, then the release wasn't purposeful or accidental. It was purposeful.
44:58Josh Clark:Okay.
44:59Chuck Bryant:And that they spread it around the Northeast, California, and then Spooner, Wisconsin, which supposedly is the actual place where the first case of Lyme disease was described in the United States in 1969, about six years before this cluster of juvenile arthritis cases popped up been old lime, lime, and east had them.
45:20Josh Clark:Well, it's a very bad idea if that's what went on, because you have to depend on a lot of things, which is A, these ticks definitely finding their way to the enemy. B, they attach to the enemy successfully and transmit the disease. And then what does it transmit? A very slow acting disease that will give people headaches and fatigue over the course of a long time.
45:47Chuck Bryant:Right, that also produces a one-of-a-kind telltale rash that tells you supposedly in plenty of time that you have this disease that needs to be treated with a simple course of oral antibiotics.
46:01Josh Clark:Yeah, and it has to be probably in the country. They don't thrive well in the city. Right. So it doesn't make a good biological weapon.
46:08Chuck Bryant:No, and then again, people who subscribe to this conspiracy theory say, well, they can't all be winners, but maybe it was just something they were experimenting with and it wasn't very good.
46:17Josh Clark:Trust me. I mean, we've done enough research on stuff our American government used to do and continue to do that it's not the most outlandish thing in the world.
46:25Chuck Bryant:No, it's not. And that's also why Chris Smith, the representative from New Jersey, shouldn't just be dismissed out of hand because it's entirely plausible. Yeah, it's not just a complete wacko idea. The other reason Chris Smith shouldn't just be dismissed out of hand is because he is a true Lyme warrior. He introduced other legislation called the TIC Act. And of course, he had to make TIC an acronym. An acronym, not an anachronism. What does it stand for? TICS, colon, Identify, Control, and Knockout Act. He was really grasping like a tick on a blade of grass with that one. But the point is—
47:05Josh Clark:But knockout's not one word unless you use it as knockout.
47:08Chuck Bryant:That's what he's saying, I guess, because it's one word. So it's really the Ticko's Act. But it would create an additional$180 million in federal funding for Lyme disease research, which is sorely needed right now.
47:22Josh Clark:That's awesome. I didn't know he was such an advocate. That's good.
47:24Chuck Bryant:He really is. He hates Lyme disease, like, a lot.
47:30Josh Clark:I was about to say something, but.
47:32Chuck Bryant:I wish I could take a pill that would bulk up my analogy region in my brain. Oh, your analogies are great. What were you going to say? I want to know. We can beep it off.
47:41Josh Clark:I was going to get political. I was going to say he hates ticks like he hates b****. Okay. Can we leave that and bleep it?
47:49Chuck Bryant:I don't know. We'll find out. All right. So the whole idea that it's a bioweapon, almost certainly not the case, right? But it makes for good press. I mean, like if you look up like Lyme disease and bioweapon, there is a lot of recent articles written on it just because a member of Congress introduced this legislation. Yeah. What a lot of people are saying is, look, it makes sense, like this conspiracy theory that people would go to that. But on the same at the same time, there's another really great explanation for it. And it's climate change, that this whole thing came about in the 70s because we're starting to see what was called the first epidemic from climate change.
48:35Chuck Bryant:And there's this really great article on Aeon, which is a great website, by Mary Beth Pfeiffer, spells it like Michelle Pfeiffer with a P, called Ticks Rising. And she's an investigative reporter, a science journalist, who really went to a lot of trouble to explain how climate change has created a new world for ticks, and we are now living in it.
48:59Josh Clark:Yeah, I mean, in 2014, the EPA actually started to use four new indicators about what's going on with climate change and the impact, and one of them was the spread of Lyme disease. So, like the EPA officially uses that as a factor and an indicator in determining the impact of climate change now.
49:19Chuck Bryant:Right. And so the whole basis of this idea is that because of warmer weather, ticks are being killed off in far fewer numbers over the winter. So they're surviving longer. As it gets warmer and warmer, higher and higher up, their range is spreading rather rapidly. Oh, yeah. And wherever these ticks go, Lyme disease is game to go with them. So the spread of Lyme disease is increasing as the spread of ticks is increasing too. And ticks have gotten totally out of hand in some areas. In that same Aeon article, Mary Beth Pfeiffer was talking about how moose are dying in their thousands in like Wisconsin and the Dakotas because they're being bled to death by 100 ,000 ticks at once.
50:08Chuck Bryant:That's amazing. That never happened before. And now all of a sudden it's kind of becoming routine because the ticks aren't dying off in the winter like they're supposed to. And again, it's because of climate change. And then in the Northeast, Chuck, one of the reasons why there's been this explosion of ticks is because there's been an explosion of deer to support the tick population.
50:28Josh Clark:Sure. Sure. Back in the day, there were things like mountain lions and there were predators that would help control the deer population. Yeah, wolves. Wolves. They're even suggesting reintroducing wolves to help control the deer population.
50:41Chuck Bryant:Oh, yeah. You can bet that's going to happen.
50:44Josh Clark:No, really. I mean, do you think so?
50:47Chuck Bryant:Yeah, totally. Like if 300 ,000 people a year are coming down with Lyme in the United States, they're going to start reintroducing wolves to combat it if it has even a half of a chance. I'd be interested to see if that happens. For sure.
51:00Josh Clark:Because humans are going to want to hunt those wolves.
51:03Chuck Bryant:Yeah.
51:04Josh Clark:You know?
51:04Chuck Bryant:It just brings it out in us for some reason, huh?
51:07Josh Clark:Well, I mean, they hunted the mountain lions. Right. But I think that's the idea of, oh, wait a minute,
51:16Chuck Bryant:really weird and circuitous bad things happen when we overhunt mountain lions and wolves. Maybe when we reintroduce them, we won't have to, you know, or we won't follow that impulse. We'll just let nature take its course. Right. Who knows? You got anything else, man? I got nothing else. So there's a solution, a round of antibiotics and some wolves, and that'll cure what ails us.
51:43Josh Clark:Yeah, advocate for yourself still, people.
51:45Chuck Bryant:Sure. And the wolves. Be persistent. That's good advice for everything, Chuck. Agreed. Almost everything. There are certainly cases where persistence is not a good idea, but you know what I'm saying, right?
51:58Josh Clark:I do know.
51:59Chuck Bryant:Okay. If you want to know more about Lyme disease, go check out all of the articles there are to read. And again, go check out the Aeon article by Mary Beth Pfeiffer. It's really interesting. And since I said it's interesting, that means it's time for Listener Mail.
52:17Josh Clark:I'm going to call this a neat story about how great Stuff You Should Know listeners are. Ooh, I like that. From Portland, Maine. Hey, guys, my wife, daughter, and I, all Stuff You Should Know listeners for years, decided last minute to buy tickets to the show while on vacation at Old Orchard Beach, Maine, just a short drive south of Portland. We had nosebleed seats, naturally, because we waited until just an hour before showtime. And that was more than cool by us, and we were totally stoked just to be there, whatever the seats. When we got to our balcony seats, a friendly fellow named Matt approached us, said he had three tickets for orchestra seats and asked if we'd like them.
52:52Josh Clark:The tickets were intended for friends of his who were stuck in Labor Day weekend traffic, couldn't make it to the show. Turns out he had been scouting the crowd for 40 minutes looking for a group of three, even enlisting the help of the ushers to find three people together. And we were the first group that he saw. A brief walk downstairs and there we were, three rows from the stage for the supremely excellent show about podcast topic redacted. Thanks to Matt and his friends being stuck in traffic. We went from not having tickets an hour before showtime to having third row, 10 minutes before you guys took stage.
53:27Josh Clark:We considered it a little piece of true magic. So while I'm confident this lengthy setup in telling you the story is way too long for the air. No. Not true, Richard Clark. The whole family would be forever grateful if you could give Matt and the Connecticut groundskeeper a huge thank you from Rich, Susan, and Emily in upstate New York for sharing those seats with us.
53:47Chuck Bryant:That is fantastic. I love our shows, man.
53:49Josh Clark:It's great. People are so kind. And that is from Richard Clark. Not Dick Clark, but Rich Clark.
53:55Chuck Bryant:Oh, that's even better. Yeah. Dick Clark's taken. That's right. And good for Rich Clark for recognizing that too. Yeah. Thanks for coming to the show, Rich, and bringing the family. And thank you, Matt, for being such a cool dude. That was very nice of you. I'm utterly unsurprised because our fans are pretty great people. Yes. Okay. Well, if you want to get in touch with us, you can go on to stuffyoushouldknow.com and you can send us a tweet or an Insta post or a comment or what have you, that kind of thing, because all of our social links are there. Or you can just do it the old-fashioned way and send an email.
54:31Chuck Bryant:Wrap it up, spank it on the bottom, and send it off to stuffpodcasts at iheartradio.com.
54:39Josh Clark:Stuff You Should Know is a production of iHeartRadio. For more podcasts from iHeartRadio, visit the iHeartRadio app, Apple Podcasts, or wherever you listen to your favorite shows.
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From the publisher
If you live in the Northeastern U.S. then you may know someone who has had Lyme disease. But it's spreading all over the country and parts of the world. Learn all about this tick-borne disease in this classic episode.
See omnystudio.com/listener for privacy information.


