The Loneliness Epidemic Is Worse Than We Thought

7 May 2026 · 26 min · 8 chapters

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In short

The episode argues that loneliness/social disconnection is a worsening public health crisis with measurable biological effects, increasing risk for heart disease, dementia/Alzheimer’s, autoimmune dysfunction, cancer progression, type 2 diabetes, and early death. It claims loneliness chronically activates inflammatory pathways (NFKB), elevates cortisol, disrupts sleep/amyloid clearance, and drives neuroinflammation. It also promotes “vulnerability” and deeper, reciprocal connection as the key behavioral lever, citing oxytocin and heart-rate variability “entrainment” research.

Guest backgrounds

No guests are interviewed; host Darin Olien speaks throughout.

Key claims + notable examples

U.S. Surgeon General advisory (Dr. Vivek Murthy); 50% of U.S. adults report measurable loneliness (vs ~20% in 1980s); 29% report no close friend; UK “Minister of Loneliness” (2018), Japan (2021), Australia strategy (2023). Meta-analysis (2015) linking social isolation/loneliness to higher premature death risk. UCLA NFKB findings; PLOS 2020 dementia risk (40% higher). Brene Brown (worthiness) and HeartMath (HRV synchronization).

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

Tap a time to open that second in VO

Understanding Loneliness

2:13 to 4:47

Exploring the concept of loneliness and its biological implications.

“And it doesn't have to be someone physically next to you.”

The Loneliness Epidemic

4:48 to 8:00

Darin discusses the statistics and societal implications of loneliness.

“And today is the episode I've been building on for years, and I'm about to tell you about it.”

The Biological Impact of Loneliness

8:01 to 14:00

Exploring how loneliness affects health at a cellular level.

“Loneliness is not a feeling to be managed.”

Impact of Inflammation on Well-Being

14:00 to 14:21

Learn how inflammation affects sleep, mood, and motivation.

“So this disrupts the sleep, increases the inflammatory markers and turns on a whole bunch of gene expression just by that alone.”

The Loneliness-Alzheimer's Connection

17:54 to 19:27

Explore the link between loneliness and Alzheimer's disease risk.

“You will not want to miss this incredible deal and this incredible uptick to your healthy cells.”

The Biological Impact of Social Connections

19:27 to 21:07

Uncover how social interactions affect our biological health.

“We have traded the convenience of maintaining real, deep, vulnerable friendships for the convenience of surface-level digital connection, and we are paying for it.”

The Power of Vulnerability in Relationships

21:07 to 23:14

Understand how vulnerability strengthens social bonds and personal growth.

“So the real barrier, my friends, that we can change, I believe, is vulnerability.”

Practical Steps to Enhance Connections

23:14 to 25:59

Learn actionable strategies to deepen your social connections.

“Take a piece of paper, write down some names of every person in your life, and genuinely, is there something, is there a judgment I'm holding on someone?”
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Transcript

Automatic transcript. May contain errors.

0:03Darin Olien:Welcome to Super Life with me, Darin Olien, a podcast where we explore, discover, and share solutions that promote a healthier life and a better world. Together, we'll ignite possibilities, inspire change, and build sovereignty, creating a roadmap towards a super life for you and for all. Get ready to start living your super life.

0:32You know, I'm absolutely obsessed with what I put in my body. And by the way, you should too. However, the NAD market is certainly exploding right now. And here's the shocking truth. Independent tests showed that 87 % of the supplements, the NR supplements, which is the precursor for NAD, had not what they advertised in it. And many of them had zero of the NR in the product at all. And that is a problem. That's why I believe you need to choose TrueNiogen. TrueNiogen is the research pioneer in this space, full stop. I fully support TrueNiogen because of their commitment to quality assurance and safety for what is in the product is verified and supported scientifically.

1:31That's why TrueNiogen's independent verification and tests is so important. The whole brands of trust us and just buy the product is not good enough. It needs to be verified. It needs to be supported. So you can confidently know that what you're buying and what you are taking is exactly what's in the product. So why would you gamble with your health with people that aren't supporting it with their own tests? Support the companies that are supporting you. So all you have to do is go to trueniogen.com. Use the promo code Darren20 and you get 20 % off. That's Darren20TrueNiogen.com

2:42Darin Olien:truly known by them. That's the difference. And it doesn't have to be someone physically next to you. And you also can be lonely with someone physically next to you. However, being understood by someone, being seen by someone deeply is powerful. Here's what I didn't know then, but that I know now, that loneliness, that specific invisible kind of ache was not just an emotional experience. It was all throughout my body, a slow fire triggering a cascade of now that I see biological events inside every cell that was contributing to biological risk, which we're going to get into today. Some of those risks I discovered, which we'll talk about, is increased heart disease, dementia, autoimmune dysfunction, cancer, and early death.

3:44Darin Olien:That's right. And this is not fringe science. It is some of the most replicated, well-funded, consensus-driven and research in all of modern medicine. And almost nobody is talking about it in the health and wellness space. We talk about food all the time. We talk about the right supplements. We talk about sleep, movement, about stress. All of those are important, of course. But we almost never talk about the number one predictor of how long you live, how healthy you will be, your happiness quotient, and how much capacity you have of joy. That predictor is the quality of your close relationships.

4:35Underscore quality. So it's not just happening.

4:39Darin Olien:There's something I'll discover later in the episode that will give you a key to being able to cultivate this. I'm Darren O 'Lean. This is Super Life. And today is the episode I've been building on for years, and I'm about to tell you about it. So here's the thing. We absolutely have a loneliness epidemic in the world, and it's getting worse. In the May of 2023, the U.S. Surgeon General, Dr. Vivek Murthy, did something that had never been done before. he issued a formal advisory, the same distinctions used for the AIDS crisis or the opioid crisis. Now listen, just because you're creating an advisory situation doesn't mean the problem's away, but at least it's on the radar.

5:33Darin Olien:Because it was declaring that loneliness and social disconnection is a national public health crisis, not a social problem, not a mental health concern, Of course, all of those play in, but a public health crisis on par with epidemics that killed hundreds of thousands of people. Here are the numbers, and I need you to literally sit down for these. 50 % of all American adults report measurable levels of loneliness, up from roughly only 20 % in the 1980s. This is not a blip or a hiccup. It is a generational collapse of connection. 29 % of adults say they have no one they consider a close friend.

6:31Darin Olien:29%. That number has tripled since 1990. 26 minutes less. the average person, the average American spends 26 fewer minutes per day in a face-to-face social interaction compared to 2003. Less face-to-face connection. That's across every age group, every demographic, full stop. And this isn't uniquely American. The UK appointed the Minister of Loneliness in 2018 after their research found that over 9 million people, nearly one in six, often or always felt lonely. Let that sink in. Japan followed in 2021. Australia launched a national loneliness strategy in 2023. Are you seeing a theme? We have built the most connected-looking civilization in human history.

7:38Darin Olien:More smartphones, more social platforms, more ways to connect anyone at any place on the globe almost instantaneously. And we are more isolated than at any point in recorded modern history. Something has gone catastrophically wrong. and the body is keeping score. This isn't just a feeling. This has ramifications. Loneliness is not a feeling to be managed. It's a biological alarm as primal and as urgent as hunger or thirst. And when we ignore it long enough, it begins to eat at us from the inside. Unquote. Before you tell yourself this isn't you, like I did, let me describe who we're actually talking about.

8:36Darin Olien:Because loneliness looks nothing like the image most of us carry around in our heads. It's not just the elderly widow eating alone at home. it's the 34 year old CEO who hasn't been in a vulnerable conversation with anyone in his adult years now we're going to go back to vulnerability because that is a key and it's also the new mom who is physically never alone but feels utterly unseen it's the guy who has a fantasy football group chat, but no one he could call at 2 a.m. in a real crisis. It's the person with 3 ,000 followers and four real friends and who's slowly replacing the real friends with a scroll.

9:31Darin Olien:The research confirms this. Loneliness has almost nothing to do with how many people are around you and almost everything to do with whether you are genuinely known, valued, seen, and securely connected to even just a few people. The clinical term is perceived as social isolation, and the body responds to perceived isolation almost identically to actual physical isolation. Your brain cannot tell the difference between being alone on a desert island and being in a room full of people who don't really see you. So just let that sink in. There was a meta-analysis in 2015 in perspectives on psychological science, analyzing 70 studies covering 3.4 million people across multiple continents and found that social isolation increases the risk of premature death by 26%, loneliness by 26%, and living alone by 32%.

10:46Darin Olien:To put that in perspective, those figures exceed the mortality risk of obesity, which is 18%. It's almost double. Physical inactivity estimates between 20 % and 30 % and are comparable to smoking 15 cigarettes a day. This was not a survey study. It was a synthesis of mortality outcomes across millions of real human lives. So I'm going to nerd out here for a second just for the people that want to know what the hell is biologically going on and what may be going on in our genes. So here's where the science gets wild and kind of extraordinary. And that's where this stops the conversation about feelings per se and becomes a conversation about what's going on biologically.

11:44Darin Olien:Inside your cell, there's a protein complex. I didn't even know about this before I dug into this. There's a protein complex called NFKB, nuclear factor kappa B. It's one of the master regulators of what? Your immune system. and it controls the expression of dozens of pro-inflammatory genes. NFKB is supposed to activate in short bursts in response to actual infections or tissue damage. It ramps up inflammation to fight the threat, to fight what your body needs. Then it backs down. This is the design. But researchers at UCLA made a stunning discovery. social isolation and perceived loneliness reliably and consistently upregulated this NFKB activity.

12:40Darin Olien:Loneliness literally turns on inflammatory genes at the transcriptional level in your genes. It changes which of your genes are being expressed and it does it chronically. Because the loneliness doesn't resolve. What does chronic NFKB activation cause, you ask? Cardiovascular disease, Alzheimer's, cancer progression, type 2 diabetes, autoimmune flares, accelerated cellular aging. This is not a metaphor. This is a molecular pathway. The science, which I grabbed a lot, is also in the show notes. Cortisol and sleep inflammation cascade. It doesn't stop at the gene level. The cascade happens every single day chronically with lonely people.

13:37Loneliness signals threat.

13:40Darin Olien:Threats trigger the stress axis, the HPA axis, which pumps cortisol, elevates the cortisol at night, destroys sleep, destroys the architecture. and where the brain tries to clear the amyloid plaques, it doesn't get a chance to. So this disrupts the sleep, increases the inflammatory markers and turns on a whole bunch of gene expression just by that alone. Elevated inflammation, worsening moods, reduces motivation, increased pain sensitivity. It goes on and on and on. I'd like to take a quick break from this episode to thank our sponsor, Fatty15. That's right. I want to talk about something that isn't talked about enough, keeping our cells healthy.

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15:29Darin Olien:That's right. They're susceptible to oxygen and sunlight and the supplements can't even help to improve our health usually. But fatty 15 or C15 naturally protects against damaging oxidation both in the bottle and in your body. If you want to get a little more sciencey about it, studies show that C15 works by strengthening our cells, improving our mitochondria function, and protecting us against damage from free radicals on a very deep level. The result? Better long-term metabolic liver and heart health functioning. It ends up many of us are massively deficient in C15, which results in weaker and weaker cells that makes us have less energy and we quit working earlier.

16:20Darin Olien:We're seeking to find that energy. Where is it? All of this makes us age faster and faster, and the science around this is so fascinating. We sleep poorly, we feel sluggish, and we're all looking to feel better and have more energy. Does it sound familiar? Fatty 15 is science-backed, award-winning, vegan-friendly, and pure C15 supplement. That's it. By replenishing ourselves with this newly discovered C15, the nutrient of fatty 15 effectively repairs our cells and restores our long-term health. That's when you have to celebrate science. When science discovered something sitting there all along.

17:11Darin Olien:After 90 years of discovering essential fatty acids like omega-3, 6, and 9, we now have discovered this incredible odd chain saturated fat C15. Fatty15 is on a mission to replenish your C15 levels and restore your long-term health. And I'm with them in that. You can get an additional 15 % off your 90-day subscription starter kit by going to Fatty15, F-A-T-T-Y-1-5.com slash Darren, D-A-R-I-N, or use the code Darren, D-A-R-I-N, at checkout. You will not want to miss this incredible deal and this incredible uptick to your healthy cells. There is also an Alzheimer's connection nobody talks about. Think about it.

18:07Darin Olien:Alzheimer's is the ultimate loneliness. You're in your own bubble and you can't remember people. You can't have interactions. So I want to spend a moment here because this is wild. Loneliness is now one of the most robust modifiable risk factors of Alzheimer's disease ever identified. A study in 2020 in PLOS, P-L-O-S-1, following over 12 ,000 people found that those reporting high levels of loneliness had a 40 % greater risk of developing dementia compared to those with strong social ties. That's 40%. The mechanism is dual. The cortisol disrupts sleep, allows amyloid beta plaque to accumulate faster.

19:03The protein tangles associated with Alzheimer's and chronically elevated neuroinflammation

19:12Darin Olien:accelerates the degradation of neural networks. Your brain is literally shrinking. The hippocampus, your memory center, is measurably smaller in chronic, lonely people. This is an ultimate fatal convenience. We have traded the convenience of maintaining real, deep, vulnerable friendships for the convenience of surface-level digital connection, and we are paying for it. for cognitive decline, years of quality of life, true quality, and the epidemic of preventable diseases. There is also oxytocin economy. If you don't connect with someone deeply, you're missing out on genuine, warm, reciprocal social connections, where your brain releases is oxytocin, dopamine, serotonin, endorphins, all four simultaneously.

20:13Darin Olien:Oxytocin specifically is the most anti-inflammatory molecule in the human body. Hug someone, hug someone longer. Look at them, look at them longer. Connect with them, connect with them deeper. This research is astonishing. Research from HeartMath Institute shows that emotional, warm, coherent social connection synchronizes heart rate variability between people. Your nervous system actually entrains. You borrow each other's calm. You regulate each other's biology. So we are definitely, definitely connected. This isn't soft science. It's one of the most elegant examples in all of medicine of how our social environment is literally our biology.

21:07So the real barrier, my friends, that we can change, I believe, is vulnerability. The willingness

21:15Darin Olien:to be vulnerable, share how you feel, because that creates, I see you, I want to be close to you. And this is, vulnerability is a massive topic. Maybe one day I'll talk a lot about it. But I have experienced vulnerability, certainly in the last few months, at a depth that is extraordinary. And every time, I didn't want to do it, necessarily. I mean, I did, but it's uncomfortable because you're getting vulnerable. I had one of the most powerful conversations I've ever had with my brother, my mother, ex-partners i mean two my ex-wife and an ex-partner and it created a level of i owned stuff that i should have owned a long time ago but no there's no shoulds but i just got vulnerable i also got vulnerable with in a good way with how much i appreciate people in my life stepping in and giving compliments and being the source of the vulnerability which every time and i'm talking in 10 different conversations with different people in my life, every time it's met, every time it's wanted, every time those people gives them the permission to step in.

22:33Darin Olien:It's extraordinary. Research by Brene Brown at the University of Houston on over a decade of interviews identified one clear distinguishing factor between people who had deep, nourishing social connections and those who didn't. those with social, those with connection believed they were worthy of it. That's it. Not that they were more charming or more interesting or more whatever. They simply believed. They embodied the belief and they stepped in. This is incredible. This is one of the greatest things that I've researched right now and sharing with you. What can you do? Take a depth audit. Take a piece of paper, write down some names of every person in your life, and genuinely, is there something, is there a judgment I'm holding on someone?

23:26Darin Olien:Can I own something? You don't have to go into it going, I need them to apologize. No, just own your shit. Or just, I haven't told them how much I care about them. I haven't told them how much I appreciate them. I haven't told them how much I love them. And just in the middle of the day, there's no perfect time. So if you're holding back, that is the point to lean in. Schedule time today to be with someone without the phones. Schedule a sacred hour, go for a hike, leave the phones in the car. Just sit with someone. Just listen without your mind needing to fill the gaps of their story. just listen to someone.

24:10Darin Olien:Vulnerability creates the opening. What's actually hard for you right now? Ask someone that. What's going on for you? I'm here to listen. Is there anything you haven't talked to anyone about lately? And or come to that yourself going, hey, something's on my heart today. I told my brother how much I respected him and holding, being the glue to our family and helping my mom and helping everyone around he's he does it unapologetically no matter what for anybody in our family incredible so i told him all these things vulnerability just gets blown away because other things seem to be more important protect yourself from social media and scrolling be present in your relationships look for connection even when you're going to a grocery store, look people in the eye.

25:04Darin Olien:And if they have a cool shirt on them, say, man, that's a cool shirt, brother, sister, with not needing anything in return. Be the source of happiness and joy and connection. Instead of your head down, worried about nothing, just ruminating nonsense. So I was lonely sitting here in the yurt for seven years. Yes, I love it out here. I've cultivated a life with my two dogs and oak trees and I was feeling lonely. It wasn't crippling me. It was subtle. I do have deep friendships, but I just went deeper, meaningful, not flippant conversations, acknowledging great people in my life at any time, no matter what.

25:58Darin Olien:So if you are feeling lonely in any way, there's ways that you can change it. Get vulnerable. Open your heart. If you want love, give love. You want connection, create connection. Be the source of your life. Generate the kindness, the care that you want to see, and it will come back to you. This is Super Life. I'm Darren O 'Lean. Peace.

From the publisher

What if loneliness isn't just an emotion… but one of the most dangerous biological threats to your health?

In this deeply personal and scientifically explosive solo episode, Darin opens up about something he recently realized in his own life: despite being surrounded by people, he was lonely. But what began as an emotional realization quickly became a deep dive into some of the most shocking research he's ever uncovered, showing that chronic loneliness may increase the risk of heart disease, dementia, cancer, autoimmune dysfunction, accelerated aging, and early death.

From inflammatory gene expression and cortisol dysregulation to oxytocin, vulnerability, and the collapse of real human connection in the digital age, this episode reveals why loneliness may be the most overlooked "fatal convenience" of modern life, and how vulnerability may be the medicine.

What You'll Learn
  • Why loneliness is a biological crisis, not just an emotional feeling
  • The shocking link between loneliness and heart disease, dementia, and early death
  • Why the quality of your relationships is the #1 predictor of long-term health
  • How loneliness activates inflammatory genes inside your body
  • The role of cortisol, sleep disruption, and chronic stress in social isolation
  • Why social media and "surface-level connection" are replacing real intimacy
  • The connection between loneliness and Alzheimer's disease
  • How oxytocin and genuine connection reduce inflammation
  • Why vulnerability is the gateway to meaningful relationships
  • Practical ways to create deeper connection starting today
Chapters

00:00:33 – Sponsor: the truth about the exploding NAD supplement market

00:01:04 – Why supplement verification and transparency matter

00:02:17 – Opening: Darin admits something deeply personal

00:02:30 – "I realized recently… I'm lonely"

00:02:37 – The difference between being surrounded by people vs being truly known

00:03:06 – Loneliness as a biological experience, not just an emotional one

00:03:27 – The hidden risks: heart disease, dementia, cancer, early death

00:03:45 – Why this is not fringe science

00:04:13 – The most important predictor of long-term health

00:04:34 – Why relationship QUALITY matters more than quantity

00:05:06 – The global loneliness epidemic

00:05:11 – U.S. Surgeon General advisory on loneliness

00:05:39 – Loneliness declared a public health crisis

00:06:02 – 50% of Americans report measurable loneliness

00:06:22 – "A generational collapse of connection"

00:06:30 – 29% of adults have no close friends

00:06:40 – Face-to-face interactions dramatically declining

00:07:01 – The UK, Japan, and Australia loneliness crisis initiatives

00:07:32 – The paradox: hyperconnected but deeply isolated

00:08:04 – Loneliness as a biological alarm signal

00:08:31 – What loneliness actually looks like in modern life

00:08:42 – The lonely CEO, the unseen mother, the isolated social media addict

00:09:31 – "Perceived social isolation" and why the brain can't tell the difference

00:10:21 – Meta-analysis of 3.4 million people

00:10:55 – Loneliness vs obesity and smoking risk comparisons

00:11:18 – The biology of loneliness begins

00:11:50 – NF-kB: inflammatory gene activation explained

00:12:33 – How loneliness changes gene expression

00:13:02 – Chronic inflammation and disease pathways

00:13:21 – Cortisol, sleep disruption, and immune dysfunction

00:14:00 – How loneliness affects brain repair and amyloid plaque clearing

00:14:21 – Sponsor: Fatty15 and cellular health

00:18:02 – The Alzheimer's and dementia connection

00:18:25 – Loneliness as a major modifiable dementia risk factor

00:18:57 – Cortisol, neuroinflammation, and brain degeneration

00:19:16 – The hippocampus physically shrinking in lonely people

00:19:27 – Social media as a "fatal convenience"

00:19:57 – The oxytocin economy: connection as medicine

00:20:15 – Oxytocin as one of the body's strongest anti-inflammatory molecules

00:20:30 – HeartMath research: emotional synchronization between people

00:20:48 – "You regulate each other's biology"

00:21:07 – The real barrier: vulnerability

00:21:32 – Darin's recent experiences with radical vulnerability

00:21:54 – Conversations with family, ex-partners, and loved ones

00:22:35 – Brené Brown's research on connection and worthiness

00:23:14 – The "depth audit" exercise

00:23:42 – Reaching out, expressing appreciation, and owning your emotions

00:24:01 – Sacred hours: spending time without phones

00:24:13 – Questions that create real intimacy

00:24:30 – Darin's emotional conversation with his brother

00:25:03 – Protecting yourself from social media disconnection

00:25:20 – Becoming a source of joy and connection in everyday life

00:25:25 – Darin reflects on seven years of subtle loneliness

00:25:48 – The shift from surface conversations to meaningful connection

00:26:01 – "If you want love, give love"

00:26:19 – Final message: generate the connection you want to receive

00:26:22 – Closing thoughts and outro

Thank You to Our Sponsors
  • Truniagen: Go to www.truniagen.com and use code DARIN20 at checkout for 20% off

  • Fatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/DARIN and using code DARIN at checkout.

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Connect with Darin Olien: Key Takeaway

"Loneliness isn't weakness. It isn't failure. It's a biological signal telling you that something essential is missing. And in a world addicted to surface-level connection, the real medicine may simply be this: vulnerability, presence, eye contact, honesty, and the courage to let yourself truly be seen."

Bibliography/Sources

The Loneliness Epidemic & Public Health Data

  • Bureau of Labor Statistics. (2023). American time use survey. U.S. Department of Labor.

https://www.bls.gov/tus/

  • Cigna. (2023). Cigna U.S. loneliness index. Evernorth Health Services.

https://newsroom.cigna.com/loneliness-epidemic-continues-to-rise-cigna-study

  • Murthy, V. H. (2023). Our epidemic of loneliness and isolation: The U.S. Surgeon General's advisory on the healing effects of social connection and community. U.S. Department of Health and Human Services.

https://www.hhs.gov/sites/default/files/surgeon-general-social-connection-advisory.pdf

  • Survey Center on American Life. (2021). The state of American friendship: Change, challenges, and loss. American Enterprise Institute.

https://www.americansurveycenter.org/research/the-state-of-american-friendship-change-challenges-and-loss/

Mortality & Systemic Health Risk

  • Cohen, S., Doyle, W. J., Skoner, D. P., Rabin, B. S., & Gwaltney, J. M. (1997). Social ties and susceptibility to the common cold. JAMA, 277(24), 1940–1944.

https://pubmed.ncbi.nlm.nih.gov/9200634/

  • Hawkley, L. C., & Cacioppo, J. T. (2010). Loneliness matters: A theoretical and empirical review of consequences and mechanisms. Annals of Behavioral Medicine, 40(2), 218–227.

https://pubmed.ncbi.nlm.nih.gov/20396846/

  • Holt-Lunstad, J., Smith, T. B., Baker, M., Harris, T., & Stephenson, D. (2015). Loneliness and social isolation as risk factors for mortality: A meta-analytic review. Perspectives on Psychological Science, 10(2), 227–237.

https://doi.org/10.1177/1745691614568352

  • Valtorta, N. K., Kanaan, M., Gilbody, S., Ronzi, S., & Hanratty, B. (2016). Loneliness and social isolation as risk factors for coronary heart disease and stroke. Heart, 102(13), 1009–1016.

https://heart.bmj.com/content/102/13/1009

Genetics, Inflammation & The Immune System

  • Cole, S. W. (2013). Social regulation of human gene expression: Mechanisms and implications for public health. American Journal of Public Health, 103(S1), S84–S92.

https://pmc.ncbi.nlm.nih.gov/articles/PMC3786756/

  • Cole, S. W., Hawkley, L. C., Arevalo, J. M. G., Sung, C. Y., Rose, R. M., & Cacioppo, J. T. (2007). Social regulation of gene expression in human leukocytes. Genome Biology, 8(9), Article R189.

https://pmc.ncbi.nlm.nih.gov/articles/PMC2375027/

Sleep & Cognitive Decline

  • Cacioppo, J. T., Hawkley, L. C., Berntson, G. G., Ernst, J. M., Gibbs, A. C., Stickgold, R., & Hobson, J. A. (2002). Do lonely days invade the nights? Potential social modulation of sleep efficiency. Psychological Science, 13(4), 384–387.

https://pubmed.ncbi.nlm.nih.gov/12137144/

  • Holwerda, T. J., Deeg, D. J. H., Beekman, A. T. F., et al. (2014). Feelings of loneliness, but not social isolation, predict dementia onset. Journal of Neurology, Neurosurgery & Psychiatry, 85(2), 135–142.

https://jnnp.bmj.com/content/85/2/135

Oxytocin & The Biology of Connection

  • Szeto, A., Sun-Suslow, N., Mendez, A. J., Hernandez, R. I., Wagner, K. V., & McCabe, P. M. (2017). Regulation of the macrophage oxytocin receptor in response to inflammation. American Journal of Physiology—Endocrinology and Metabolism, 312(2), E183–E189.

https://journals.physiology.org/doi/full/10.1152/ajpendo.00424.2016

  • Uvnas-Moberg, K. (2003). The oxytocin factor: Tapping the hormone of calm, love, and healing. Da Capo Press.

https://books.google.com/books?id=b-aKjQoB_nQC

Psychology, Vulnerability & Relationship Science

  • Aron, A., Melinat, E., Aron, E. N., Vallone, R. D., & Bator, R. J. (1997). The experimental generation of interpersonal closeness. Personality and Social Psychology Bulletin, 23(4), 363–377.

https://doi.org/10.1177/0146167297234003

  • Brown, B. (2010). The gifts of imperfection: Let go of who you think you're supposed to be and embrace who you are. Hazelden Publishing.

https://brenebrown.com/book/the-gifts-of-imperfection/

  • Cacioppo, J. T., & Patrick, W. (2008). Loneliness: Human nature and the need for social connection. W. W. Norton & Company.

https://wwnorton.com/books/9780393335286

  • Dunbar, R. I. M. (2012). Bridging evolutionary approaches to the social brain and social bonding. In F. B. M. de Waal & P. F. Ferrari (Eds.), The primate mind. Harvard University Press.

https://www.hup.harvard.edu/books/9780674063104

  • Dunbar, R. I. M. (2021). Friends: Understanding the power of our most important relationships. Little, Brown and Company.

https://www.hachettebookgroup.com/titles/robin-dunbar/friends/9781408711736/

  • Waldinger, R., & Schulz, M. (2023). The good life: Lessons from the world's longest scientific study on happiness. Simon & Schuster.

https://www.simonandschuster.com/books/The-Good-Life/Robert-Waldinger/9781982166694

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