In short
a16z Podcast Episode Notes: Why America’s Health Crisis Is an Incentive Problem
Episode Overview In this episode of the a16z Podcast, Erik Torenberg converses with Justin Mares, founder and CEO of TrueMed, about the troubling state of American health outcomes compared to other developed nations. They explore the origins of the current health crisis, the role of crop subsidies in creating a food system that promotes unhealthiness, and innovative solutions to tackle chronic diseases.
Key Themes and Concepts
- Current Health Crisis in America
- Poor Health Outcomes: The U.S. ranks poorly in health metrics, with high rates of obesity and chronic diseases.
- Environmental Factors: The discussion emphasizes that chronic disease may be more of an environmental issue rather than purely a healthcare problem.
- Role of Food System
- Ultra-Processed Foods: A significant portion of American diets consists of ultra-processed foods, contributing to poor health.
- Historical Context: The 1970s marked a turning point when food production began to prioritize profitability over nutritional value.
- Crop Subsidies: Government subsidies for corn, soy, and wheat have led to a food system that outputs unhealthy products at low costs.
- Proposed Solutions
- TrueMed’s Approach: TrueMed enables users to spend tax-free HSA and FSA dollars on lifestyle interventions such as gym memberships and healthier food options.
- Preventative Care Incentives: The podcast discusses the need to shift the healthcare model from treatment to prevention, with financial incentives to promote healthy lifestyles.
- Chronic Disease as a National Security Issue
- Health as a Priority: The hosts argue that chronic health issues should be treated as a national security crisis, emphasizing the interconnectedness of health and societal wellbeing.
- Political and Policy Changes: Suggestions include reforming crop subsidies, improving drug regulation, and enhancing school and military meal programs.
- Emerging Therapies
- Psychedelics for Mental Health: The conversation touches on the potential for psychedelics to revolutionize mental health treatments, especially for conditions like PTSD.
- Peptides: There is speculation about how peptides could disrupt the pharmaceutical industry by offering affordable alternatives for enhancing health and wellbeing.
Key Takeaways
- A Need for Behavioral Change: The need for a paradigm shift in the healthcare system towards preventative measures and healthy lifestyle choices.
- Community Focus: The health of individuals is tied to the health of their environments; initiatives should focus on community health rather than just individual health.
- Personal Responsibility: Individuals should explore their dietary choices and how they impact their health through experimentation and biomarker tracking.
Resources
- Follow Justin Mares on X: [@jwmares](https://x.com/jwmares)
- Follow TrueMed on X: [@truemed](https://x.com/truemed)
- Listen to the a16z Podcast on [Spotify](https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX) and [Apple Podcasts](https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711).
Conclusion This episode of the a16z Podcast provides an insightful examination of America's health crisis, emphasizing the need for systemic changes in food production, healthcare incentives, and community-focused health initiatives. The conversation also highlights innovative solutions like those offered by TrueMed as potential pathways toward better health outcomes for Americans.
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VOUnderstanding America's Health Crisis
0:45 to 2:19
Discussion on the poor health outcomes in America and the impact of the environment.
“That what you eat, how you move, and where you live matter more than the pills you take.”
The Role of Food in Health
2:19 to 4:19
Exploration of how traditional diets and environments contribute to health.
“I kind of came across that idea when I was 20.”
The Amish Lifestyle and Health Outcomes
4:19 to 5:04
A look at the health practices of the Amish and their impact on well-being.
“Just as an example, what do they do differently?”
Historical Shift in Food Quality
5:04 to 6:29
Examining how the 1970s marked a decline in food quality and health outcomes.
“Or was there sort of a moment where things started to escalate?”
The Impact of Crop Subsidies
6:29 to 8:16
Analyzing how U.S. crop subsidies contribute to unhealthy eating patterns.
“Like most kids today are eating like 70 % of their diet is ultra processed foods.”
Chronic Disease and Healthcare Solutions
8:16 to 10:45
Discussion on the healthcare system's failure to incentivize prevention.
“I mean, the U.S., our food system, relative to like Europe or something like that.”
The New Food Pyramid and Nutrition Guidelines
10:45 to 11:34
Overview of recent improvements in U.S. nutritional guidelines and their implications.
“like have to solve the food issue if we want to have a healthy country.”
Opportunities for Health Innovations
11:34 to 13:00
Identifying potential business opportunities in health and nutrition.
“So I think there are tremendous, tremendously positive stuff.”
Incentivizing Preventive Health Care
14:00 to 16:04
Exploration of how financial incentives can shift focus towards preventive health measures.
“I can do all of these things that will prevent an acute heart attack or something like that.”
The Mismatch Between Genes and Environment
16:04 to 17:41
Discussion on how the environment influences health outcomes using animal analogies.
“hundreds of billions of dollars towards lifestyle interventions over the next couple of years.”
Show all 22 chapters
Health as a National Security Concern
17:41 to 19:16
Connecting the dots between public health, national security, and the obesity crisis.
“Like how do we promote human health and flourishing?”
Regulating Chemical Safety and Health
19:16 to 22:09
Insights on chemical regulation differences between the U.S. and the EU and their health implications.
“What would, you know, you gave one example of, and the subsidies, what are some of the biggest levers you think?”
Challenges for Startups in the Food and Health Space
22:09 to 24:21
Exploration of barriers startups face in competing with large food corporations and their lobbying power.
“And it's something you're going to hear a lot more about in the coming years.”
Rethinking Grocery Stores as Health Interventions
24:21 to 27:05
Proposal for grocery stores to integrate health intervention strategies into their operations.
“it becomes very, very challenging for a startup to kind of come along and make a real play at some of these things.”
The Role of Psychedelics in Health
27:05 to 28:05
Discussion on the potential benefits of psychedelics in treating mental health issues.
“Are some of these ingredients that we're discussing or foods or, you know, soda, like so dangerous, so addicting or so dangerous or so appeasant that they should be outlawed?”
Psychedelics as a Treatment Option
28:05 to 29:43
Explore the potential of psychedelics in addressing mental health issues.
“And like, if we don't take effort to uniquely like address this thing, I think that the U.S.”
Integrating Biological and Mental Health
29:45 to 30:56
Understand the connection between physical health and mental well-being.
“I think that we are hugely underestimating the impact of biological health and how that is tied to mental health.”
Curiosity About Consciousness
30:56 to 33:17
Delve into the philosophical exploration of consciousness and its implications.
“idea that many diseases that we put in the mental health bucket, things like epilepsy, depression, schizophrenia, many of these things have causes that are actually metabolic and root.”
Community Health Initiatives
33:17 to 34:38
Learn about the importance of community in improving overall health.
“Well, obviously you're focused on building TrueMed.”
TrueMed's Approach to Healthcare
34:38 to 36:14
Discover how TrueMed incentivizes healthy lifestyle choices through tax benefits.
“So if I had copies of myself, I would explore companies in that direction.”
The Future of Peptides in Healthcare
36:14 to 37:39
Examine the potential impact of peptides on the healthcare system.
“And I actually have to ask, what are your thoughts on peptides and any predictions as it relates?”
Nutritional Science and Dietary Experimentation
37:39 to 40:35
Investigate the challenges in nutritional science and the importance of personal experimentation.
“You got into the repeat diet or you were writing about it.”
Transcript
Automatic transcript. May contain errors.0:00You look at our food system today, the majority of what people are eating is ultra-processed crap. The average child spends less time outside than like a maximum security prison that people are spending, he plus hours on phone. We are in the midst of one of the biggest problems in the country. If we don't fix this, like America is going to have even more serious problems. The environment that we exist in is just structurally just hard to be healthy, which is why you see the default health outcomes in the U.S. being so poor. Why not just universal basic ozempic? Why doesn't that solve the problem?
0:25I think now the problem is we're feeding our kids poison and like all of them are sick. I think many of our problems are downstream of the fact that the majority of the country is just sick. No matter if we get richer or whatever, if most of the country is sick, it's kind of like, what is the point?
0:39Erik Torenberg:What if the chronic disease crisis isn't a health care problem, but an environmental one? Justin Maris has spent 15 years building companies around a single idea. That what you eat, how you move, and where you live matter more than the pills you take. His great-grandmother lived to 95 without ever shopping organic or asking for no seed oils. She didn't have to. She grew up in an environment that wasn't actively making her sick. Today, the average American child spends less time outside than a maximum security prisoner. 70 % of their diet is ultra processed food. Almost 80 % of adults are overweight or obese.
1:12Erik Torenberg:And the healthcare system will pay hundreds of thousands or millions of dollars to manage a heart attack, but nothing to prevent one. TrueMed is trying to change that math. The company allows people to spend tax-free HSA and FSA dollars on lifestyle interventions. Gym memberships, better food, sleep aids, that treat, reverse, or prevent chronic disease. The idea is simple. If we're going to fix American healthcare, we have to make prevention as easy to pay for us treatment. I speak with TruMed founder and CEO Justin about why the 1970s were the turning point for American health, how crop subsidies created a poisonous food system, and why peptides might be the most disruptive thing to hit healthcare in decades.
1:52Erik Torenberg:you've been on a quest for the last few years to uncover and make a dent in solving our food crisis our health crisis our disease crisis why don't you trace your journey a little bit to how you became obsessed with this and then we'll get into what we're up to yeah so peter steel has this idea of like a secret and i feel like the idea that what you eat your lifestyle all these things they impact your health outcomes, they impact your energy, they impact how you feel. I kind of came across that idea when I was 20. And it felt like this secret where if you look at any data in the U.S., U.S. healthcare outcomes are horrible.
2:28They're bad. They're getting worse, like obesity, heart disease, all of these conditions are basically at record levels and continue to go up. And as I started to read more about our food system, about environmental toxins, about all these sorts of things, I just became more and more convinced that everyone's like, what's going on with our obesity crisis? Why are we so sick? And the answer is just simply that we exist in an environment that systematically outputs unhealthy people. And that this idea that you could just change your food, change your diet, change your exercise, change your environment, and that would lead to much better health outcomes naturally, feels to me like this secret that, you know, I've believed and invested behind and started companies behind for 15 years, that still the average person does not totally fully internalize.
3:11And so I just became obsessed with this idea the first time I came across it when I was like 20 or so.
3:16Erik Torenberg:And you yourself have gone out of your way to go against the grain in terms of your own personal life and trying to be healthy, but it's very difficult to be healthy today. It's almost like people used to say when they were canceling people on Twitter all the time, hey, just build your own Twitter. Like, you want your own information, you can just build your own. And similarly, like you have to build your own like food. Totally. Yeah, I mean, in so many ways, I feel like health used to just be an output of the environment that we exist in. Like my great-grandmother, she lived till she was 95, very healthy until the day that she died.
3:45And she never shopped organic. She never like avoided and asked for no seed oils at the grocery store. She never did like any of the insanity that I've kind of had to learn, figure out and do. That's because primarily she lived and grew up in an environment that was not sickness promoting. She was not exposed to 40 ,000 novel chemical compounds that exist in the U.S. or eating foods that were like addictive and made her feel shitty and like impacted her health. And so I think that the environment that we exist in is just structurally just hard to be healthy, which is why you see the default health outcomes in the U.S.
4:19being so poor. And how are the Amish exempt from this? Just as an example, what do they do differently? I mean, they do a lot differently. You should go to one of the communities. There's a lot of things they do very differently than you and I. But basically, they're eating food that is grown locally, seasonally all the time. They're outside all the time, working with their hands. They're existing in a tight-knit community. And there's like a whole host of environmental and lifestyle differences that the Amish have. So you can argue, do you have to live like the Amish to have better health outcomes?
4:48But certainly, they have much better health outcomes, and they live very differently than you or I. But they're not doom-scrolling like us, so how do they make it?
4:55Erik Torenberg:It's like they might live longer. They're uninformed, I know. They might live longer, but at what cost? So when did things start to get really bad? Or has it just been monotonically for the last century? Or was there sort of a moment where things started to escalate? And what happened? Yeah, things started to get much worse in the 1970s. My view is that that is around the time when you started to see childhood obesity tick up. You started to see obesity, heart disease, things like this kind of start to move. And in my view, a big reason for that is there was a lot of shareholder and other pressure, specifically geared towards big food companies around that time where basically these companies are today like 150 years old.
5:33Almost every big food company is shareholder owned. They are not run, controlled or anything by CEOs. They're basically just like these lumbering corporations that the market is just having them optimize for like earnings per share. And what that means is these companies for the last 50 years have consistently decided to trade a real ingredient for something that's like kind of a fake version of that. Like they've moved from strawberries to strawberry flavoring, or they've moved from sugar to high fructose quart syrup. And you kind of roll this out over a 50-year period and you look at our food system today and the majority of what people are eating is ultra-processed crap that is like addictive, is not nutrient-dense, and is full of like environmental toxins, chemical compounds, things like this that the human body has in our entire millions of years of evolution never encountered many of these compounds.
6:21And so I think that that shift started in the 70s. It's compounded generationally. It certainly doesn't help today that the average child spends less time outside than like a maximum security prisoner. Like most kids today are eating like 70 % of their diet is ultra processed foods. People are spending eight plus hours on phones. Like all these sorts of things are factors. But I really think that our food system started to become uniquely poisonous in the 70s. And especially in the U.S., that's why you started to see many health care and health outcomes trend in such a negative direction, especially relative to the rest of the world.
6:53Erik Torenberg:What are the levers that could make a dent in reversing some of these trends as it relates to the food system? Yeah, from a food system standpoint, I think the biggest single lever that we could pull, which would be extraordinarily politically challenging to pull, is fixing our crop subsidy system. So if you look, the U.S. government, I think it's the last decade, has spent close to$100 billion on crop subsidies. They're basically subsidizing corn, soy, and wheat so that American farmers can grow corn, soy, and wheat. Because it's subsidized, it's artificially cheap, So we grow a lot of it because it's subsidized.
7:23It's artificially cheap. And so these big food companies use it in everything. And so these big food companies have basically gone on like a 30-year journey to replace sugar with high fructose corn syrup or to replace olive oil or something like that with soybean oil, which is highly processed and inflammatory, causes obesity and all sorts of like rat and human models. And I think that this sort of wholesale swapping of let's take the worst ingredients in their most highly processed form and replace them with an ingredient that humans traditionally ate is one of the root causes of chronic disease.
7:53Like today, the average American gets almost 20 % of their caloric intake from soybean oil. This is historically anomalous. And it's not because anyone wants soybean oil. Like you're probably not like a big consumer of soybean oil or anything like this. It's just because it's artificially cheap. And because it's artificially cheap, it ends up in everything. And I think that that is one of the core kind of root causes of what is going wrong in our food system today. And is that a uniquely U.S. problem? Yeah, it's a uniquely U.S. problem. I mean, the U.S., our food system, relative to like Europe or something like that.
8:23Europe, many of their countries are smaller. They tend to lean much more into a local food agriculture system. They also don't have as much of a federal intervention on their food system. The U.S., like in many ways, this sort of subsidy of corn, soy, wheat, things like that, it had good intent. I mean, a lot of the crop subsidy stuff started with a farm bill in the 80s where basically like farmers were exposed to inclement weather, bad weather that was like impacting their crop yields. The US government stepped in and was like, okay, we're gonna try and keep these farmers solvent. I think that the intent was good, but now here we are, like years later, we have billions a year going towards these crop subsidies that are making Americans sick.
9:02And I think that we used to say, okay, we just need to make sure that we're growing enough calories and make sure that Americans are not dying of starvation. They're not like, you know, make sure our kids have enough to eat. I think now the problem is like we're feeding our kids poison and all of them are sick. Why not just universal basic ozempic? I mean, why doesn't that solve the problem? Yeah, well, so I think there's two things. One, I think that GLP-1s are potentially an incredibly interesting technology. Like I think that we are in the midst of the worst chronic disease crisis, one of the biggest problems in the country.
9:34And if we don't fix this, like America is going to have even more serious problems like 20 years from now. So given that the average American is overweight, we're looking at almost 80 % obesity overweight rates. I think that it does make sense to put a bunch of these people on a GLP-1 to try and jumpstart them in a direction where they are moving towards health. That said, I don't at all think that giving universal GLP-1s to everyone is like necessarily a universal solve. There's just a very poor history of saying, here is an intervention that like is going to solve all of our problems as a species.
10:10You know, and I just think that it is quite unlikely that Ozempic is the one thing that is going to be a cure-all. Like just to use one example, what is, you know, how does Ozempic work? Is it basically, it turns down someone's appetite. So you're just eating less. If you're still eating the same crap that the average American is eating today, but you're on Ozempic and eating less of it, like you are almost certainly going to be deficient in protein and micronutrients and a bunch of things that will have like long-term health implications if you like under eat or get exposed to not enough of those nutrients for a very long period of time.
10:44So I think we fundamentally like have to solve the food issue if we want to have a healthy country.
10:49Erik Torenberg:By the way, have we yet updated our food pyramid in the sense that we have an accurate understanding of what we should be getting at a country level in terms of nutrients? Yeah, I mean, the new food pyramid is a tremendous improvement over the old guidelines. I mean, not only is the site super sexy, you know, Joe Gebbia did a great job on that. But finally, for the first time, people are saying like, eat whole foods, eat more vegetables, eat, you know, meats and like other well-sourced sources of protein, vegetables, fruits. It's crazy that it took until now to say maybe we shouldn't be giving kids, you know, 15 servings of whole grain and saying that like sugar is totally fine for kids under two.
11:27Like we recommend some amount of sugar for kids on the age of two, which was the past, you know, past administration sort of guidelines. So I think there are tremendous, tremendously positive stuff.
11:37Erik Torenberg:And so for people who want to make a difference in the food system, you mentioned that policy recommendation. What about people want to do something direct that you obviously, you know, before TrueMed, you started a bone broth company. What are other big companies that could be built in the space or opportunities to make a difference? Yeah, I think there's a ton of opportunities. I mean, within the space that I, like I think the core problem is that a bunch of these lifestyle interventions, like eating a healthier diet, exercising, taking certain supplements, taking like peptides, if that makes sense for your sort of individual person and risk profile, all of these things can be considered healthcare interventions.
12:14And yet, if you look at our healthcare system, nothing in the healthcare system thinks about someone who is at risk of heart disease exercising as a healthcare intervention. No payer pays for it. No one incentivizes you to do that. It's just sort of like a doctor is like, yeah, you should like clean up your diet and exercise. And so I think that there is a tremendous, tremendous opportunity for people that want to make a dent on this problem, figuring out how to make these sorts of lifestyle interventions part of the healthcare system is what we're doing at TrueMed and incentivizing people to actually invest in their health, to invest in prevention, to invest in things that like move the needle from a chronic disease standpoint.
12:50Erik Torenberg:Yeah. So let's get to TruMed. First, trace the idea maze a little bit in terms of, you know, you've been obsessed with this problem, sort of meta problem, this series of problems. And it's kind of like, where do you even start? I'm sure you, you know, picked over every nook and cranny. How did you settle that? Hey, this was the opportunity. What were maybe some other things you would consider? Yeah. So in growing Kettle and Fire, basically, when we launched, it was like$16 a carton for 16 ounces of bone broth. And everyone was like, this is good, but this is like very expensive. And now, nine years in, we're in every grocery store in the country and the average price per box is like$7.
13:26Way more people buy it, but they're also like, this is very expensive. I kind of like had that experience and then looked at things like Costco and Walmart are the two largest sellers of organic products in the country. To me, that is a signal that like people want to invest in products that are good for them. They want to buy products that leave them off better, healthier and like but it's just cost prohibitive. And then if you look at the healthcare system, we have this weird dynamic where if I am at risk of cardiovascular disease or heart disease, like I basically can exercise, I can eat well, I can do all of these things that will prevent an acute heart attack or something like that.
14:04And I'm basically not, that's all like cash pay. I'm paying out of pocket. I'm doing all of that kind of stuff totally on my own. Whereas if you take someone that doesn't do any of those things, basically they have a heart attack early and then the healthcare system will pay hundreds of thousands or millions of dollars to manage that person's condition basically for the rest of their lives. And so I think that fundamentally, like we need to incentivize people to invest in prevention, to invest in, you know, leveraging lifestyle interventions that can make a dent on chronic conditions. And that was kind of the lens through which I was looking at what's the company that I want to start after Kettle and Fire.
14:40When I met Dr. Mark Hyman, who is basically, you know, he's a functional medicine doctor, or co-founder function, he mentioned that something he was doing with a bunch of his patients was for patients that would come in, he would recommend lifestyle interventions and he would write them something called a letter of medical necessity, which is basically a letter that the IRS has said for certain people where an intervention matches, matches like a lifestyle intervention, matches a condition someone's working to treat, reverse, or prevent, they can spend, they can get that letter and use tax-free HSA, FSA dollars on sleep aids, healthy, you know, better diet, supplements, exercise, things like that.
15:19And so when Mark Hyman told us kind of about that idea, I was like, this is a really interesting thing. Like we could basically try and build infrastructure that allows the average person to get one of these elements, if they qualify, and use like the telemedicine rails that HIMSS, Rho, and other companies have spent the last several years building. But rather than prescribing Ozempic or prescribing TRT, we can actually prescribe food interventions, exercise, things like that. So that was kind of the idea and like where it started from. I looked at a whole host of other things like thought about starting a grocery store, thought about starting like a life insurance company that would be aggressive in terms of like helping you live longer and making lifestyle interventions.
16:03But ultimately felt like this was the type of thing that had the potential to direct hundreds of billions of dollars towards lifestyle interventions over the next couple of years. And so it felt like it was the right thing to do.
16:16Erik Torenberg:Yeah, everyone knows we need to shift more, you know, from chronic to preventive care. And this is basically a way to financially incentivize people to do that. Exactly, yeah, exactly. One of your ideas is that the root cause of a lot of issues is this mismatch between our genes and our environment. Why don't you flesh that out a little bit more? Yeah, so if you look, like, think of an animal in the zoo. Like, an animal in the wild with few exceptions. Like they can get, break their leg, get an infection, whatever. But when an animal is like, exists in a species appropriate environment, that animal tends to be healthy.
16:54Like there's a natural match between the health of the environment and the health of an animal. When you take an animal away from its natural habitat and put it in the zoo or something like that, like zoo animals exhibit all of these diseases that their counterparts in the wild just don't get. They have weird ticks, they get depressed. You know, in some notable cases, like animals have even killed themselves, which is just something you like don't see in the wild. And they get obese, they get all sorts of things. And so my take and what I think is very true is that the health of an animal is basically a reflection of the health of an animal's environment.
17:28If an animal is existing in an environment that is not health promoting, like you're in a season of drought or there's not a lot of food, that animal gets skinny and dies. Like you basically can kind of see that that animal is not existing in an environment that's health promoting. I think that over the last 100 years or so, we basically as humans have seen, you know, we've built an environment that is not considering or not underwriting, not thinking about what is the right thing to do for human health. Like how do we promote human health and flourishing? and so I think that so often when we think about health we think about like what is going on with you Eric with this specific condition as opposed to thinking about what is the environment that you exist in that leads to you not getting 8 ,000 steps a day that leads to you spending all day on your phone that leads to you like eating a terrible diet no not you know not you actually but I mean so so I think that that is like an important idea that people don't think about enough is just how do you shape your environment so that it's naturally health promoting as opposed to, you know, having to like discipline yourself and doing all the stuff that most people frankly fail at, myself included.
18:33Erik Torenberg:There's this, you know, there's this Twitter competition for a million dollars for who gets the best article. And there's this like, so people are doing kind of clickbait stuff. And there's one guy who's like, you know, how to change your life in a day, how to change your life in an hour, like these kinds of posts. And there was one that went super viral that was how to change your life in one minute. And it was a photo of smashing the phone. That's pretty good. Totally. The, um. Okay, so I'm curious for more, you know, you've talked about this idea of, hey, we should take this health crisis as serious as we take sort of our, you know, national security crisis.
19:06Erik Torenberg:Like, you know, we as a country have something of a NRA for health or something of a, you know, collective effort because it's a, you know, problem that, hey, the market might not solve, isn't solving on its own. And in fact, you know, exacerbates. What would, you know, you gave one example of, and the subsidies, what are some of the biggest levers you think? Yeah. So I'll answer that. But like just to frame how I think about the problem, you know, if, for example, like China or one of our adversaries deployed a bioweapon that made 75 percent of our population obese or overweight, 45 percent of kids obese or overweight, like and health care, like the largest cost in the country all of a sudden because everyone was sick.
19:48everyone in America would be up in arms and trying to figure out like, how do we solve this as an existential crisis? This is like a matter of national security that we make a dent on that. You know, no matter if we win the I-Race, get richer, whatever, if most of the country is sick, it's kind of like, what is the point? You know, we're not thriving as a nation. I think many of our political problems are downstream of the fact that many, the majority of the country is just sick. And so if I was like able to wave a magic wand and do anything, I think fixing the subsidies would be one thing for sure.
20:17that I would do. Secondly, I would have our healthcare system just invest far more in prevention. You look at other countries that have incredible health outcomes on a per capita basis. Singapore is a good example. They basically have these people that are not quite doctors, but are like coaches or something like that, that will check in with you and try and nudge you towards making better choices. Then I would take a much stronger stance, one much more similar to that that Europe takes when it comes to like certain environmental toxins, chemical regulation, things like that. Like in the US, we basically take the approach that if a company makes or manufactures a totally novel environmental chemical, that as long as they tell us under current regulations, something called grass generally recognized as safe, as long as they tell us, hey, this chemical is safe, we can introduce it into our food system.
21:10This is how like you've heard of the forever chemicals and stuff like this got into our food system and basically are all over the planet now because 3M invented them something like 60 years ago. And basically they just started using them. In the EU, these novel chemical compounds have to go through something that is much more like what it takes to unleash or get a pharmaceutical approved in the US today, where they have to do many years of safety testing. They have to show that it doesn't cause acute harm. And they basically have to approve it before it's allowed on the market. And the end result is we have between like 60 and 80 ,000 chemical compounds in the U.S.
Read the full transcript
21:47that are not allowed in the EU. And I think that that regulatory approach is one of like the hidden reasons why so many people are sick. And I think is one of the reasons that, you know, the U.S. Americans are exposed to more toxic compounds and novel chemical compounds than basically any nation in the world. And I think that is like a big kind of hidden part of our chronic disease crisis. And it's something you're going to hear a lot more about in the coming years.
22:13Erik Torenberg:Yeah, fascinating. I had one college professor, I have no idea if this is remotely accurate, but they were convinced that Monsanto was evil. Not just in terms of its, you know, health impacts, but they thought they were sort of like getting involved in all sorts of foreign wars and like influencing our foreign policy and stuff. And I just say that to say, could there be competitors to some of these like mega players? Like could startups even emerge that would begin to, or is it just like structurally unsound? I think it's really hard structurally. And I think that that doesn't mean that it's not going to happen and hopefully it will.
22:45But one of the things that you have seen is with Monsanto, for example, like the pesticide lobby and the chemical and ag lobby is one of the strongest in America. And a big part of what they're doing is like, for example, a couple months ago, Monsanto was lobbying hard, spent tens of millions of dollars to get a rider and a bill that would basically make sure that no one could ever sue them for the potential health impacts of one of their most popular products, glyphosate. That sort of thing is like these companies get big, they provide a bunch of chemicals. Monsanto specifically has done a lot of things that I think are incredibly morally dubious.
23:28And then once they get big enough, once they start selling billions and billions of dollars of these products, they spend a lot of that money on lobbying and making sure that they are immune from any of the harms and health impacts that come from some of these toxic products that they spray everywhere. Glyphosate is the number one pesticide sprayed in the U.S. And the largest maker of it is spending as much as they possibly can to make sure that glyphosate, which there's been$14 billion of damages awarded to people that have gotten cancer or other diseases from glyphosate exposure. Monsanto is spending as much as they can to try and buy basically like pesticide liability shields and other things that shield them from competition and that shield them from the actions and the consequences of like the diseases, their compounds of cause.
24:14I think that when these companies can kind of rig the game in that way, it becomes very, very challenging for a startup to kind of come along and make a real play at some of these things. Yeah.
24:29Erik Torenberg:You mentioned a grocery store just as a simple idea. Yeah. Is there, what's the opportunity that Whole Foods hasn't done with what they've tried to do? Yeah. I mean, Whole Foods is amazing. And so I think that John Mackey was like a total pioneer and like legendary entrepreneur. I think that the thing that grocery stores have not really done is, and this is kind of the thesis for TrueMed is like, think about food as like a healthcare intervention. And to me, I think there's a ton of potential for people to, for example, like look at their biomarkers and have a grocery store or some other entity that is responsible for improving your health.
25:05Like, I think that if you think increasingly about food, grocery as a health intervention, as like part of one's healthcare and, you know, part of the fight against chronic disease, you would think about a grocery store very differently than today, which is basically just like, let's figure out the sourcing and then people can buy whatever they want. So I think there's like, you know, my idea was that I think there's a ton of room for a grocery store that is a more active participant in your, in your health, telling you to eat certain things, you know, tracking your macros, like all these sorts of things that I think would solve a lot of problems for people.
25:39Erik Torenberg:Yeah. So let's talk more about if we, you know, fully identified the health crisis as one of our main sort of national priorities, what else we would do? Maybe we could start looking at it in the light of like, what were some of the pillars or main principles? And maybe we talk about where they are so far. Yeah. So I think that you have seen across all of healthcare, across all of food, just corporate capture of our food guidelines, of our health guidelines, of all these sorts of things. Like the previous FDA commissioner, you know, their stated goal with running the FDA, their number one goal was to combat misinformation.
26:12The current one is to like make Americans healthy. That means grass reform. So cleaning up like how we regulate chemicals. That means fixing school lunches, fixing like military lunches. Basically what we feed kids, you know, 80 % of schools have contracts with soda companies. These soda companies literally like will pay a school district to put these vending machines all over the schools. It helps fund schools, but it also like comes to the cost of getting kids sick. So I think like cleaning up school lunches, cleaning up military lunches, cleaning up like the food guidelines. Second thing is like improving and streamlining the way that we look at regulating drugs, make it faster for companies to like lean in and launch innovative therapies that can make a dent on the chronic disease crisis.
26:56And just trying to like bring common sense back into the way that we think about health, the way that we think about food and try and make a dent in the chronic disease crisis.
27:05Erik Torenberg:Are some of these ingredients that we're discussing or foods or, you know, soda, like so dangerous, so addicting or so dangerous or so appeasant that they should be outlawed? Or is it like, how do we think about it? No, I actually don't think that many of these things should be outlawed. Like I do actually think that consumer choice is a very important thing. You know, but we have got like specifically with kids, we have guidelines and we already don't think that kids should have free choice. Like we don't let them drink. So I think that there is a place for soda in this country. I just also think that if you want to drink soda all the time, that probably we shouldn't be subsidizing it by subsidizing high fructose corn syrup.
27:43probably we should not have Coca-Cola spending$140 million to influence our nutrition guidelines like they have over the last, you know, 15 years. And I think that it's things like that where a lot of times the big food companies and people will sort of fall back on this idea of consumer choice. I think it's very important, but we also are like currently grappling with an incredibly important chronic disease crisis. And like, if we don't take effort to uniquely like address this thing, I think that the U.S. is like in an incredibly tough spot 10, 20, 30 years from now.
28:17Erik Torenberg:I want to ask you about psychedelics. And I'm like, is that in this discourse at all? Does that move outcomes? Or is that kind of not really? Not really? I think that if you just look at the data, psychedelics are an incredibly powerful intervention. Like ketamine therapy, ketamine assisted therapy works better than SSRIs in many cases, especially for treating things that are very intense, like treatment-resistant depression, PTSD, things like this. I think that for many of our veterans and others that suffer from PTSD and intense depression, psychedelics should be part of a menu of treatments that we are open to giving people.
28:53I think that we probably vastly underinvest in them. I think that there's a ton of really promising research around their efficacy and things like this. I think it's an open question of like how ready the average American is to think about these things not as like a group of people dropping acid in Golden Gate Park in the 60s but as like a vital mental health therapy for people that are really really struggling I'm very supportive of you know again just looking at psychedelics as another therapy that can address the many mental health and depression issues that we have in this country and if you look at it just as that through that lens a therapy that has few to no side effects, especially when done with doctor oversight and things like this, I think they should be part of how we treat and address many of the mental health crises that we see today.
29:45Erik Torenberg:Are there any other really big levers that you would focus on if one of your main goals was to target the mental health crisis? I think that we are hugely underestimating the impact of biological health and how that is tied to mental health. There's some really interesting studies out there around taking a functional medicine approach where, you know, you come in and say you're depressed and rather than like doing talk therapy and things like this, that statistics show like sort of don't work very well for many people. We focus just on like reducing your inflammation and fixing your gut. And there've been studies that show just by focusing and taking a functional medicine approach, you know, focusing on sleep, focusing on gut health, focusing on lowering your inflammation through diet and exercise, that combination of therapies works better than, you know, just talk therapy and things like that.
30:32So I think that we massively underestimate the degree to which we are, you know, human beings who are biological organisms and like our mental health is very tightly coupled to our emotional, you know, sorry, to our physical health. And so I would have much, I think that we should fund much, much more research along these lines of what's called metabolic psychiatry, which is basically this idea that many diseases that we put in the mental health bucket, things like epilepsy, depression, schizophrenia, many of these things have causes that are actually metabolic and root. And like, for example, one of the best therapies for someone that is schizophrenic or epileptic, or even in many cases, bipolar, if you put them on a ketogenic diet, these things will, in many cases, just resolve.
31:19That is not a thing that our current mental health
31:24Erik Torenberg:world really underwrites. Yeah. Yeah, it reminds me of a conversation I once had with Daniel Gross when he was saying, hey, anytime someone is feeling depressed, it would behoove them to, you know, before attributing it to some psychological, you know, defect or making some deep psychoanalysis about it. First, just saying, hey, am I sleeping well? Am I eating well? Yeah. Am I exercising? Totally. Have I been outside recently? Yeah. Totally. the um i want to shift lastly to another topic um that you've just been really curious about um for a while which is which is consciousness um what has sort of your driven your your hunch or curiosity there and and and where is your thinking drawn you yeah i think that i have just been interested in this idea of like what what does it mean to be healthy what does it mean to live a life that people are like excited about, have energy with, you know, have energy and are just like, what does it mean to like feel great in your body and your mind and everything?
32:22And I think that consciousness is sort of this root layer of like, what does it mean to, what is your experience of being alive, of life? And frankly, like we don't really have a great answer to this right now. You know, like a lot of our theories and philosophies and things of like, what is consciousness are not great. They're not predictive. and you ask the average person, you ask even like philosophers that have thought a lot about this. And there's nothing near consensus. And so I think that I don't, it is an area that I'm very interested in. I think we're going to learn a lot about in the next decade.
32:57I hope to like have friends and like play somewhat of a role in like exploring and learning more about what consciousness is, like how to change it, how to improve it, you know, all these sorts of things. But yeah, I would put it very much like personal pet interest bucket. Not like I'm doing anything around it right now.
33:16Erik Torenberg:Yeah. Well, obviously you're focused on building TrueMed. We'll close there. But if you could scale yourself, you know, infinitely, like for people listening who are like also obsessed with this problem, is there something else you think is underexplored, whether it's a research area or a company idea or some sort of policy thing that not enough people are looking into that we haven't yet discussed that you want more people to spend? Yeah. Yeah, an idea I've been thinking about recently is, like we mentioned at the beginning, that the health of an organism is like the health of your environment.
33:46And in my view, what that means is that if we started thinking about not improving just Eric's health, but improving the health of like all of your friends and community and people around you that exist in the same environment, like intervening and improving your environment could have a much larger impact on health than just like optimizing your own health. And so I think that there's like potentially interesting models of improving one's environment, whether that's building like a health oriented city or town or like suburb, you know, development or something like that. Whether that's like group health insurance for people that are deciding to live differently and like make have different interventions and invest in sort of like root cause lifestyle interventions.
34:27I think there's a lot of interesting things that could come about when you start thinking about health through the lens of a community or like tens, hundreds of people, not just through the lens of like me as an individual. So if I had copies of myself, I would explore companies in that direction.
34:42Erik Torenberg:Yeah, I love that. Let's close on TrueMed and go deeper into it in the sense of we're obviously, the company's done phenomenally. We're obviously very lucky to be a part of it. say more for people who are not in terms of the actual product and the direction in terms of where it's going. Sure. Yeah, so TruMed, basically what it is is we, for people that qualify, we allow them to spend tax-free HSA and FSA dollars on things that treat, reverse, and prevent disease that fall within the lifestyle intervention category. So we're partners with 8Sleep, we're partnered with Peloton, we're partnered with Momentus, Lifetime Fitness.
35:17All of these brands that, you know, for someone that is working to treat, reverse, and prevent heart disease or obesity or things like this, these lifestyle interventions are healthcare. And so we've built a payment integration that allows people to spend their tax-free HSAF, say, dollars on these interventions and are scaling that up. Like, I think that where this can go over the next decade is every American that is at risk or has some sort of chronic condition should be incentivized, and tax-free money is a great incentive, to spend their own money, their dollars, on things that treat, reverse, or prevent disease.
35:48And there's no mechanisms in today's healthcare system for someone to actually spend, you know, for someone to get like a gym membership for cheaper than the list price or to get a gym membership covered by their employer, by an insurance provider like that. And so that's kind of the thing, the way that I think about what we're building is building infrastructure that allows people and incentivizes them to invest in lifestyle interventions to stave off and prevent different chronic conditions. Yeah.
36:14Erik Torenberg:And I actually have to ask, what are your thoughts on peptides and any predictions as it relates? Oh, man, I think peptides are going to be so disruptive to our current healthcare system. You know, I think that if you look at peptides, there needs to be way more research. I'm like not totally yet a peptide believer, but there needs to be way more research. But from early signs and even just like N of 1, people taking these things and using them, this seems like a class of compounds that are very effective. They are not patentable. You know, like you can basically buy these for fairly cheap. And I would put them in the bucket of like human enhancement companies.
36:53Like our current healthcare system and most of our pharmaceuticals are kind of like, don't die. Like, oh, here's a statin, like don't die, take this pill. I think that these peptides are in a different class where many of them are like, give me more energy, improve your sex drive, lower your inflammation. improve your gut health. Like they're just a different category of compound. And I think that as many people start to experiment with them and try them and things like this, you're going to see like really interesting, positive healthcare, you know, outcomes from a class of compounds that like no one has thought about for a long period of time.
37:30I think it's going to be exceptionally disruptive to pharma and to like a bunch of other players in the healthcare system.
37:36Erik Torenberg:And I'm also curious for you You were just collectively like, are we learning more about, you know, optimizing our nutrition? You got into the repeat diet or you were writing about it. What are your thoughts there more broadly? I think that nutrition science is probably among the worst of the sciences in the U.S. right now. You know, most of nutrition science is funded by a big food company. They outfund the NIH like 11 to 1 on nutrition science, at least historically. It's hopefully changing. I think that there are all of these different diet tribes out there. The Peters, the Ray P crowd, I think is one that's particularly interesting that's focused on like ramping up your metabolism.
38:18But I think that for many people, you should just kind of try and experiment with the diet that where you feel good. Like we now have lab tests that you can get, you know, via function or something like that to show how does this diet impact your energy, your biomarkers, things like this. You have wearables that can actually give you feedback around how is your sleep? How's your HRV? How's your resting heart rate since switching your diet or since doing things differently? And I think that that combination of like getting insight into how these things are actually making you feel and how they're impacting your biomarkers means that people should be just way more open to experimenting and seeing like, hey, I'll try a p-dating diet for like 90 days and just see how I feel.
39:00So I'm very bullish on like people doing end of one dietary like exploration and experimentation. And I think that the peating community is like probably the most interesting one out there for me right now. And why is that? Because there is like two schools of thought, basically. There's like the Brian Johnson school of thought, which is we've done all the research. We know that you need to eat a plant-based diet. We know that you need to do caloric restriction all in the name of longevity. That is like the current dogma in many ways. The Peters are the exact opposite. And, you know, and Brian Johnson would say like sugar is bad.
39:34You should not eat carbohydrates, all this. The Peters are like, you should eat as much sugar as you possibly can, mostly in the form of like honey and fruit and stuff like this. You should try and avoid, like hugely avoid seed oils, hugely avoid things that are going to impair your metabolism. But if Brian Johnson is like, I want to eat less and ramp down my metabolism. It means I can live longer. The Peters are like ramp it up as much as you can. And like the more energy you have, the longer you are able to use that energy over a long period of time. And so it is like such a contrarian view to a hundred years of nutrition dogma that says sugar is bad, should be avoided, that I think it's a very interesting idea.
40:16And a lot of the people in the Petey community have seen phenomenal results. It's like I've started drinking orange juice and like eating fruit in the morning. And like, I feel great. My biomarkers have gotten even better from, you know, I've been doing probably a decade plus of like mostly low carb kind of paleo. And so it's just a very interesting, different lens that is worth playing with.
40:34Erik Torenberg:Yeah. No, essentially, I'll have to check out the Peters. You know, Brian Johnson's obviously been so interesting on so many topics. One question I was curious, if I, you know, if I get a girlfriend, should I make a launch video? So Justin, the company is TrueMed. Thank you so much for coming on the podcast. Thanks for having me on. Lucky to be involved. Thanks for listening to this episode of the A16Z podcast. If you liked this episode, be sure to like, comment, subscribe, leave us a rating or review and share it with your friends and family. For more episodes, go to YouTube, Apple Podcasts and Spotify.
41:08Erik Torenberg:Follow us on X at A16Z and subscribe to our Substack at a16z.substack.com. Thanks again for listening, and I'll see you in the next episode. As a reminder, the content here is for informational purposes only. It should not be taken as legal, business, tax, or investment advice, or be used to evaluate any investment or security, and is not directed at any investors or potential investors in any A16Z fund. Please note that A16Z and its affiliates may also maintain investments in the companies discussed in this podcast. For more details, including a link to our investments, please see a16z.com forward slash disclosures.
From the publisher
a16z general partner Erik Torenberg speaks with Justin Mares, founder and CEO of TrueMed. They discuss why American health outcomes are so poor compared to the rest of the developed world, how crop subsidies created a food system that "systematically outputs unhealthy people," and what it would take to treat the chronic disease crisis as a national security issue. Mares explains how TrueMed allows people to spend tax-free HSA and FSA dollars on lifestyle interventions like gym memberships, sleep aids, and healthier food—and why he believes this could redirect hundreds of billions of dollars toward prevention. They also explore the case for psychedelics as mental health therapy and why peptides could disrupt the pharmaceutical industry.
Resources:
Follow Justin Mares on X: https://x.com/jwmares
Follow TrueMed on X: https://x.com/truemed
Stay Updated:
If you enjoyed this episode, be sure to like, subscribe, and share with your friends!
Find a16z on X: https://twitter.com/a16z
Find a16z on LinkedIn: https://www.linkedin.com/company/a16z
Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX
Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711
Follow our host: https://x.com/eriktorenberg
Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see http://a16z.com/disclosures.
Stay Updated:
Find a16z on X
Find a16z on LinkedIn
Listen to the a16z Show on Spotify
Listen to the a16z Show on Apple Podcasts
Follow our host: https://twitter.com/eriktorenberg
Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
