What Women Need to Build Muscle & Lose Fat with Nutritionists Mikki Williden, PhD & Brandon DaCruz

3 Sep 2026 · 1 h 2 min · 17 chapters

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In short

Midlife women’s fat loss and muscle retention, focusing on protein targets, how GLP-1s fit into sustainable dieting, and when to use protein-sparing modified fasts/rapid fat loss (including “low energy availability” vs energy deficit).

Guests

  • Brandon DaCruz, PhD: Nutrition researcher/clinician; cites meta-analyses and dose-response research on protein in deficits; emphasizes appetite, adherence, and metabolic/health markers.
  • Mikki Williden, PhD: Clinical nutritionist; adds practical considerations (appetite regulation, adherence) and discusses protein “floors” and metabolic health; mentions essential amino acid supplementation for low-appetite contexts (e.g., GLP-1).

Key claims

  • Protein “ceiling” of 1.6 g/kg is context-dependent; in deficits, higher targets help preserve lean mass.
  • Practical heuristic: aim around 1 g per pound; higher in deficits/for recomp.
  • GLP-1s are tools (appetite suppression), not plans; results depend on maintaining protein/fiber/training and lifestyle behaviors.
  • Rapid fat loss/PSMF should be short-term, nutrient-dense, high-protein, and not for chronic use; assess labs and risk (bone/hormones).

Notable examples

  • Protein in deficit: 2.5 g/kg vs 0.9 g/kg in women physique-athlete study improved recomp (more fat loss + more muscle).
  • GLP-1 weight loss magnitudes cited (e.g., semaglutide ~15% over 68 weeks; other agents higher).
  • Rapid fat loss originally 7–14 days; extreme multi-month use risks nutrient deficiencies and lean-mass loss.

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

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Introduction of Guests and Discussion Setup

1:20 to 2:24

Hosts introduce nutritionists Brandon and Mickey for a roundtable discussion.

“I think a lot of people think they're doing the right thing.”

The Importance of Context in Nutrition

2:24 to 4:00

Understanding the importance of personalized nutrition advice for women.

“I'm thrilled to be here and especially to be on the line with both of you.”

Protein Recommendations and Misunderstandings

4:00 to 5:06

Exploring protein intake recommendations and common misconceptions.

“And I'm going to say this because it's been a little controversy online as of late, which I think kind of fluctuates where we hear these absolutes and then somebody else is saying this.”

Analyzing Protein Needs in Different Conditions

5:06 to 10:13

Dive into the various protein needs based on energy balance and goals.

“And then there's this other camp and this other research that comes out that they're pointing to that's like, well, yeah, it does matter if you're in a deficit or it can help with hypertrophy.”

Practical Advice on Protein Intake

10:13 to 14:00

Offering practical protein intake strategies for women aiming for fitness goals.

“And actually the Martin Raffaello data from 2025, a linear dose response, the more protein, the more favorable increases in fat-free mass.”

Understanding Protein Intake for Muscle Health

14:00 to 17:00

Learn the importance of sufficient protein intake for muscle metabolism and appetite regulation.

“better than the 1.6 ceiling or 0.75 grams per pound if we're getting nitty gritty.”

GLP-1 and the Shift in Dieting Trends

17:02 to 22:20

Explore the impact of GLP-1 medications on appetite, dieting, and long-term weight management.

“But GLP-1 takes a lot of the hunger cravings away.”

Differentiating Food Noise from Hunger

22:20 to 25:28

Understand the distinction between food noise and genuine hunger, and the implications for diet.

“from food noise, which I think has really gotten the colloquial term of food noise.”

Rapid Fat Loss and Its Considerations

25:28 to 28:00

Discuss the nuances of rapid fat loss strategies for different body types and health conditions.

“supportive of utilizing it where appropriate.”

Introduction to Fat Loss Methods

28:00 to 28:51

Discussion about differing approaches to rapid fat loss and protein-sparing modified fasts.

“in literature, we've covered in one of my groups and I had Bill Campbell come on and talk about it.”
Show all 17 chapters

Explaining Protein-Sparing Modified Fast

28:53 to 33:36

Detailed explanation of protein-sparing modified fast and its applications.

“So a protein-sparing modified fast is, as its name implies, a high-protein diet that lacks carbohydrates and direct fats, essentially.”

Calorie Cycling and Rapid Fat Loss

33:36 to 42:00

Exploration of calorie cycling and practical applications for fat loss.

“And honestly, a lot of times what I'm seeing are people that have such massive appetite suppression from GLP-1s when they're doing rapid fat loss.”

Understanding Low Energy Availability

42:00 to 48:08

Learn the difference between energy availability and energy deficits, and how they affect women's health.

“And say that I was able to induce a 1500 calorie deficit on those days.”

The Myth of Spot Reduction

48:20 to 56:00

Explore the nuances of spot reduction, including misconceptions and the role of exercise.

“I've got, this is all the question number three.”

Understanding Body Composition for Midlife Women

56:00 to 56:57

Learn how high-intensity exercise affects fat loss and the importance of low-intensity workouts.

“But I, of course, learned that from Brandon as well.”

Nutrition Strategies for Fat Loss

56:57 to 1:01:25

Discover effective strategies for creating a calorie deficit and targeting stubborn fat areas.

“back on because i feel like we barely got through a great conversation and i feel like we nailed all of these big issues but man i'd love to have a whole other two hours with you well consider it done.”

Behavioral Insights and Food Awareness

1:01:25 to 1:04:28

Understand the importance of food awareness and how personal habits impact weight loss.

“but it really came from me testing these things with myself and with other clients and then going back into the literature to find the physiology to reinforce it.”
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Transcript

Automatic transcript. May contain errors.

0:00Hey, it's Hailey. If you're a woman in midlife who has done everything right and those stubborn pounds won't move, stay with me for a minute. You cut your calories, you've added more cardio, you try harder than anyone around you, and the scale just sat there while your energy crashed and the weight crept back on. In midlife, your hormones, sleep, muscle, and your bones all change the math. I want you to be the woman who knows exactly what her body needs now and can make a fat loss phase work for her lifestyle. Fat Loss Happens Education is seven weeks of evidence-based guidance from registered nutritionists, menopause doctors, and exercise physiologists with me right there alongside you.

0:43You learn how protein, training, hormones, and recovery work together in midlife and how to hold on to your results long after the course ends. We start the live course in September. To get first access in August, go to hayleyhappensfitness.com forward slash fatlosshappenseducation or grab the link in the show notes. Now, back to the show. Tyler Reddick here from 2311 Racing. Victory Lane? Yeah, it's even better with Chumba by my side. Race to chumbacasino.com. Let's Chumba. No purchase necessary. VTW Group. Void where prohibited by law. I think a lot of people think they're doing the right thing.

1:27So they hear the problems that everyone has. They need to eat more protein, that they need to have more fiber. They have to start exercising more. And these are all likely true. But to add nuance and context, you actually have to think about yourself and have awareness of your own habits and behavior. Hi, everyone. My name is Haley. And this is Laura. And welcome to The Body Pod.

1:50Okay, I am thrilled, Brandon and Mickey, to welcome you back to the BodyPod and have this roundtable discussion. I feel like there's so many things on my list, and I'm dying to dive in with both of you that I look up to so much and really get a good grasp on some of these more nuanced questions and subjects that I think get lost in translation, sometimes with the bigger overall messaging. So welcome, both of you. Thank you so much. I'm thrilled to be here and especially to be on the line with both of you. Mickey is someone that I highly respect, one of my closest friends and confidants. And Haley, we've had great interaction, so I'm very much looking forward to this and it's an honor to be here.

2:37Similarly, this is always such a joy to jump on the call with both of you. And I love these conversations. And Hayley, particularly when you said nuance, you know, because to your point, so much of what people hear out there is just lacking the context. And I think having conversations with people like you really just allow people to filter some of it as to how it might sort of apply to them, I suppose. Yeah. And I love that both of you are so educated and so smart, but you have this beautiful way of making the research approachable and the subjects approachable. And I think in this time, we are so lucky to be alive at this time in the world, even with all of the scary things that are coming up and AI and whatever, but we have knowledge at our fingertips all the time.

3:31now with that there are definite pros and there are definite cons um so my goal of what i want to achieve here is to really get down and and give midlife women some concrete answers to the they've all heard yes we need protein we need to be strength training blah blah blah no one's here that is is hearing this for the first time that that is new but i want to start with i i'm just diving right in to protein recommendations. And I'm going to say this because it's been a little controversy online as of late, which I think kind of fluctuates where we hear these absolutes and then somebody else is saying this.

4:16And for women, Mickey, I think you and I have talked about this in some of my groups where it really isn't that confusing when you have more context to it. But to the average midlife women, it's super confusing because they're like, well, so-and-so said this, and then now I'm hearing this. And I want to start there because there's been research that's come out, and I actually dialed back the shred calories that we gave them, dialed back the protein a little bit because the research had come out that 1.6 grams per kilogram, which is around what? almost 0.75 grams per gram or pound, if we're talking about pounds.

4:59That was the ceiling. Nothing happens above the ceiling. Eat it if you want, but you're literally not getting anything more. And then there's this other camp and this other research that comes out that they're pointing to that's like, well, yeah, it does matter if you're in a deficit or it can help with hypertrophy. I want your opinions on that because I feel like I'm pretty in the know with all of you guys and the experts that I bring onto my courses, but the friction I didn't really see coming. And, um, it's with a lot of really big people in the space. What are your thoughts? What are your thoughts on the ceiling of 1.6?

5:41I don't think anything is right or wrong because there's clearly research to support everything that we can say. And before I let you dig in into that answer, I was talking with Celine Yeager a few weeks ago on a podcast, and she's like, Haley, I've written for all of these magazines for 20 years. I've written books for Stacey, Vonda, you name it, all of these different people. You can find research to back up almost anything that you're hearing out there. Now, where that comes into the nuance. So nuance, Here we go. I want both of your answers on that and how we can have a discussion there. Mickey, if you don't mind, I'll kick this off because I have a feeling that you both have discussed this.

6:23So I'll take it from an unbiased perspective. I'll give you guys the evidence and then also my practical application and you guys can throw any caveats or whatever it may be at me. So first and foremost, we have to first look at the status of energy balance a person is in. So if we are talking about women at maintenance or in surplus conditions, meaning that they have sufficient energy availability. The literature would show that 1.6 to 2.2 grams per kilogram of body weight per day would be a sufficient protein intake for maximizing muscle protein synthesis. This comes from Morton Meta-Analysis from 2018, which was based out of Stu Phillips' lab.

6:56The caveat here, and many people don't read this research, is it's compiled of around 57 studies, if I remember correctly. And if you go into the methodology of the actual study itself or the review, you'll see that there's not exclusion criteria, but in the inclusion criteria itself, it says participants cannot be, first of all, they have to be resistant trained. Secondarily, they need to be out of an energy deficit. So we have to look at energy balance in a different context. So if you were to say someone's at maintenance, someone's in a surplus, I would say the broad body of evidence would say there's a confidence interval, meaning that 95 % of the population will fall between 1.6 to 2.2 grams per kilogram per day.

7:33So 0.75 to one gram per day. Now we go into deficit conditions. Now let's think about the physiological implications of a deficit. First and foremost, if you go into an energy deficit between 20 to 33 % deficit, we see a knockdown in muscle protein synthesis. So your ability to accrue muscle tissue. So Redding colleagues found that a 20 % deficit causes like a 19 % decrease in muscle protein synthesis. And the other literature shows 27%. So just being in an energy deficit of 20 to 33 % causes a decrease in muscle protein synthetic rates of 19 to 27%. How do we rescue that? That's actually, there's a linear dose response by increasing protein can offset that when it's done in conjunction with resistant training.

8:11Now let's go to the best body of evidence. We actually have a meta regression, which looks at a linear dose response of protein intake. And I'm very fortunate that I've seen Eric Helms present on this in person. He is one of the researchers on this paper. I've spoken with Martin Ruffalo, who's a lead research primary investigator on the study. And I also have had many interactions with Eric Trexler, both in person and then online. All three of them were the reviewers for this meta regression that came out in 2025. And what they found is in deficit conditions, there's two broad-based outcomes. First and foremost, I guess the floor for retaining lean mass in a deficit is 1.9 grams per kilogram per day.

8:45So we're going from 1.6 up to 1.9. Now, if you want to maximize muscle gain in a deficit, so for body recomposition, we actually increase that. And the area is between 2.3 to 3.2 grams per kilogram per day. So we're looking, if you mathematically deduce it, divide 3.2 by 2.2, somewhere in the realm of 1.45 grams per kilogram per day. Then we look at other studies. So let's look at the broad body of literature on women. I'm going to talk right to your women. We look at Bill Campbell. He has a deficit study where they looked at two different interventional groups, and these were aspiring physique athletes in women.

9:18And they looked at a differentiation between protein intake. That was the only difference they made. Training program held constant, everything the same. They looked at 2.5 grams per kilogram per day versus 0.9. And they found that the group that had 2.5 grams per kilogram per day ate more calories, but lost more body fat and gained more muscle. They recomped. Whereas the other group lost body fat because they were in a deficit, but gained a very small portion of muscle mass itself. And so really when it comes down to it, we have to look at the differentiation between where is that person from an energetic status?

9:47Are they looking to lose fat? And many of the women that come to me, they want to recomp. We look at any of the recomp data, it's over 2.2 grams per kilogram per day, and it's certainly over 1.6. So we have to look at a, the person's energy status, their goal. If most people come to us, that's a holy grail. They want body recompensation. They want to lose that and gain muscle concomitantly. So if you are someone that you are, say you're a newbie, you're eating at maintenance, you're just getting into the gym. 1.6 is great. It's a great starting lever. It's not the ceiling though. The data does not reinforce that.

10:15And actually the Martin Raffaello data from 2025, a linear dose response, the more protein, the more favorable increases in fat-free mass. So the more muscle you gain. And that goes all the way from 1.9 to 3.2 grams per kilogram per day. And the only reason it doesn't go up even more, that's an asymptotic increase is because we don't have data beyond that. Jose Antonio has done between 3.4 to 4.4 grams per kilogram per day, but we don't have enough data on those upper intakes. So I would say broadly speaking, I would recommend what I do with clients, lean women, trying to get leaner, 2.5 to 2.7 grams per kilogram per day.

10:47And if they really are someone that's protein forward, someone like a Mickey, if she was trying to re-comp with me, we would go 3.2. Mic drop. right there. Okay. I just learned something new about that too. And that makes so much sense. Mickey, take it away. Well, I have nothing to add from the literature side of things, but if I can just add a couple of clinical comments, because this is how I think a lot of the time about the research and applying it. And I know, Hayley, you mentioned hypertrophy, which obviously is the goal for a lot of all of us sort of midlife women who we work with particularly.

11:25But I often think of elements outside of muscle protein synthesis. Like this is where all of the research is and I absolutely understand that. But when I think about appetite, when I think about adherence, when I think about how the brain feels when you've got more protein on board, these are things which I think are super important are often sort of missed in the conversation because the conversation isn't around these other sort of important factors when it comes to adhering to a deficit and just like you know living your awesome life. Now Don Lehman talks about this in a lot of podcasts and as you both know he's done so much research in the space on protein he hasn't actually published on it and I asked him about it last time I was speaking to him is that he thinks there's this metabolic sort of floor to protein intake whereby under 100 grams of protein absolute in a day, and this isn't related to body weight, but I just think it's worth mentioning, you don't get a lot of the same metabolic health benefits that you do when you eat above 100 grams of protein a day.

12:30And that's actually a relatively small amount, if we're thinking about the amounts that Brandon's mentioning here and Hayley, that a lot of the women in shred and fat loss happens would sort of be allocated. but I think that the shifts in glucose sort of management and insulin based on insulin and the sort of the cholesterol changes to cholesterol profiles like I think all of these are really important elements too so I obviously I'm aware not to there's the same detail that Brandon you know talks about you can just like you can just like reel it all off Brandon but I know of those numbers that um and the difference between the 1.6 and the 1.9 and then up um up higher but I also um so this is why I generally keep or try to keep protein high for a lot of women like a lot higher than 1.6 if they're in a deficit having said that though and I think Hayley you and I have talked about this before that sometimes if you set the bar a little bit lower people won't even reach that bar so if we're setting up at sort of 2 or 2.2 we sort of know that if they hit you know 1.8 1.9 that's actually going to get them closer to their goal than if the bar was 1.6 and they're only sort of up at 1.3 1.4 so these are just some of the things that I think about with that okay so if I'm wrapping this up are you both I know that there this can fluctuate too, but closer to one gram per pound in a lot of situations is aiming a little bit better than the 1.6 ceiling or 0.75 grams per pound if we're getting nitty gritty.

14:12Yeah. I think from a practical heuristic point of view, like if I had to give, and I work with clients all around the world, if I had to give someone a tangible piece of advice, aim for one gram and just realize that you need to track these things and this is going to be an acquired skill, but I think that that would at least cover your bases. And even if you go to the Morton data, the reason that it's 1.6 to 2.2, and they always just kind of, some researchers just hyper-focus on the 1.6, it's a confidence interval. It means it's covering 95 % of the population. The reason they did that was because there is response heterogeneity, meaning individual differences between people.

14:44So we want to cover, I would always say you'd rather err on the side of overeating protein than under eating it just to do the benefits on muscle metabolism, on metabolism in and of itself, energy expenditure levels on longevity, on appetite regulation. We look at increasing protein from 15 % to 30 % caused in a 2005 study by Weigel and colleagues of 441 calorie per day deficit spontaneously. They weren't even trying to reduce their energy intake. They lost over the course of 12 weeks, they lost something like eight pounds due to the fact that they had their appetite suppressed. So when we look at appetite regulation, we look at hunger management, we look at muscle metabolism, the body composition, the ability to accrete lean body tissue and then also recover, I think it's really more advantageous to at least hit one gram per pound.

15:28I'm in a great list. And then you're saying, Mickey, that under 100 grams, regardless of whatever, under 100 grams is not really giving you a lot of the benefits that you could be getting from this higher protein amount per day. Yeah, correct. So that's good to know too, because you have some leaner individuals, women as they get older that just don't have the appetite and eating is kind of a chore. Same thing I would say with somebody that's on a GLP-1 where it's harder for them to eat. That's kind of like you want to get a triple digit number of protein. Yeah. And practically speaking as well, Hayley, I talk to women and I'm sure Brandon does as well about utilizing essential amino acid powders that allow them to sort of just back up the protein they can eat with those essential aminos that are required for that muscle protein synthetic response, particularly with people, to your point, low appetite and on a GLP-1.

16:32Yeah. Okay. Wow. Well, that was a heavy hitter right out of the gate. I wanted to make sure that I didn't get distracted and we didn't cover that one. Keeping on with the conversation of GLP One. Tyler Reddick here from 2311 Racing. Another checkered flag for the books. Time to celebrate with Chumba. Jump in at chumbacasino.com. Let's Chumba. No purchase necessary. BTW Group. Void word prohibited by law. CTNC 21 Plus. Sponsored by Chumba Casino. So I read something the other day about, did GLP One kill fad diets? we have these keto we have paleo we have all of these ways and essentially they're just a different way that somebody can cut calories essentially and get into a deficit with maybe foods that that work for them or in their mind they're just already convinced that this is the magic diet and as we all know it comes down to energy deficit and you can get that in every diet provided you stick with it and you're tracking well, blah, blah.

17:41But GLP-1 takes a lot of the hunger cravings away. I mean, I have clients that aren't really interested in alcohol. I know Dr. Jocelyn Whitstein yesterday had posted about this new study of hormone therapy and rotator cuff injuries, but somebody had said, well, I started on a GLP-1 and my rotator cuff injury went away. And she's like, well, yeah, it helps with anti-inflammatory. So what are your thoughts on that subject? Okay. Great, Brandon. So I think this was such a great question, Hayley, about whether GLP-1s killed fad diets. And I would say the reason why a lot of people might think that is because they think that taking a GLP-1 is the plan and that's not the plan we still need the principles of sustainable fat loss in place if someone is taking a GLP-1 medication so I um and it's you know in in my experience with the clients I work with I have got clients who take the GLP-1 and they genuinely get a shift in their appetite so they're actually eating I'm not sure how to say this any other way but normal amounts of food you know but like plates of food that that we might sit down to and they're satisfied and they're putting into practice the you know the protein recommendations that we're talking about in addition to fiber etc and they're seeing results because they're able to do that but then I do also have other clients when it absolutely kills their appetite and they can't actually eat the same like um almost anything and And so there's someone that I really have to work on in terms of the essential amino acids that we were talking about and making sure they're hitting a baseline protein, which is lower, a little bit lower than the levels that we were discussing.

19:37but I think in both instances where people who might not be so well schooled in GLP-1s are talking like GLP-1 is just another fad to get someone to lose weight is that I mean quite clearly as you said Hayley as soon as you know it's no different from any diet as soon as someone comes off a medication or makes a shift like that then if they haven't instilled those lifestyle behaviors, then they've not had the opportunity to actually embed the things that they need in order to sustain the fat loss. So people can't, and if anyone's out there thinking, oh, just take a GLP-1 because it'll sort of kickstart me, but not also have in their head that they need to do the things that we all talk about every day, then they're really just kicking the can down the road, essentially, because that's not a plan.

20:30Yes. So first and foremost, I think that we have to look at and really conceptualize GLP-1 therapy for what it is. It's a tool. And as with any tool, it could be used or it could be abused. And we see people in these dichotomous camps, they're on opposite sides of the equation. Some people think it's a fad that is going to be here today and gone tomorrow. And then others really look at it for its pure pharmaceutical properties that it has. So it's the most potent appetite suppressant that we ever had. If you really look at some of the stimulant-based pharmaceutical interventions, we're looking at something between 5 % to 7 % body weight loss.

21:02And semiglutide in and of itself, Wilding colleagues in 2021 found 15 % weight loss over 68 weeks. We look at transeptide over 20%. We look at tetratide, which is not clinically approved. Everyone's jumping on board a little bit too early. We have to realize that we cannot get that from a compounding pharmacy currently, but that's looking at 25 % to 27%. So these are potent apatite suppressants, but they work in two different distinct manners. So we have GLP-1 receptors in the gastrointestinal tract, which is going to help with slowing down the transit of food. And then we also had them in the brain in the hypothalamus.

21:33And so that's going to shut off our actual appetite signals essentially, or it's going to signal satiety to the brain. And so what we really have to realize is that it is a tool that can be advantageously used in conjunction with lifestyle interventions, such as a nutrient-dense diet that's calorie controlled, proper resistant training that's going to help you build lean mass and maintain it, especially when you're in an energy deficit, high protein intake, because we were just talking about the concept of leveraging higher protein intakes for muscle retention. That's even more important if you are able to pharmaceutically induce a much larger calorie deficit than you could through adherence and just by nature itself.

22:07So I think that we have to look at this as a tool in and of itself. And perhaps what I'm seeing in practice, I'll just give you an example, is not that it's like we're putting it or pitting it against fad diets, but what I am finding in certain contexts with certain individuals that they were people that suffered from food noise, which I think has really gotten the colloquial term of food noise. If you actually look at it as compared to what it is in the literature, they're completely different. Food noise is essentially an incessant hyperfixation on food, a focus that distracts you from everyday activities, from your family, from engagements, from connecting with others.

22:39It is almost all encompassing. It could be very similarly described as something we have in the weight loss literature as hyperphagia, which is an incessant hunger that comes from a precipitous loss of lean mass during dieting, where you essentially, you go through a body fat overshooting effect. You can't stop eating your ravenous. And so people with food focus or with food noise, they essentially cannot even focus on their daily tasks, whether it be work or the relationships or their children. So this powerful pharmaceutical intervention can help with that. It's being currently tested clinically to help with food noise.

23:09And then we're also seeing the downstream implications on other behaviors that are dopamine driven, such as gambling, excessive alcohol intake. So we're seeing that it's having interactions with dopamine receptors and things of that sort. So I think that if used correctly, and by correctly, I mean dose escalated correctly with a physician, meaning starting low and titrating up as need be, it's not based on, your dose should not be. This is very funny. If you look into the menopause literature on hormone replacement therapy or menopause hormone therapy, it's not based on the actual clinical, like your clinical levels in the blood.

23:39Like if you went to the menopause hormone therapy society or menopause society in and of itself, and you looked at the MHT guidelines from 2022, it's not based on your estradiol and progesterone concentrations. Once you're on estradiol replacement and oral micronized progesterone, it's based on symptomology. So the same thing should be applied and really visualized with GLP ones. It's based on how can you suppress your appetite and that food noise that you have, not how can I ramp up my dose to the point that I'm losing a precipitous amount of weight or just rapidly crashing on the scale? Because that is actually leading to disinventageous effects where we're having a lot of people that are speaking out up against muscle loss or nutrient deficiencies or thyroidal issues.

24:18Yeah, you're in a massive calorie deficit. That's from a lack of energy availability and being in a state of relative energy deficiency. And can I just add, Brandon, because I really love how you made the distinction of food noise from what we see in the literature versus what we hear people say when, because everyone's talking about food noise now. Everyone has food noise, but that's... Everything. Yeah, exactly, Hayley. And I think people are almost, there's no judgment, but they're like, oh, I've just got this food noise. And I'm like, you know what? If you slept a little better and if you actually had that high protein breakfast and you included more fiber and maybe moved a little bit more during the day, then I think that food noise probably, well, that's not food noise.

24:57I think you're actually just probably a bit hungry. you know you've got a bit of a dysregulated appetite and so that I think that distinction is important I think sometimes some of the pushback from GL on GLPs is because not enough people are making the distinction as to why it could be helpful and so almost everyone is seeing it as almost this all-encompassing sort of cure for you know anything related to weight loss and a lot of the other things that we discussed albeit all that to say I am hugely supportive of utilizing it where appropriate. Yes. Okay. So staying on this a little bit, the subject, I want to move to protein sparing modified fast and rapid fat loss, but also kind of encompassing that with what we're seeing in Hollywood that is definitely rapid fat loss.

25:52and I'm sure use of GLP ones with a lot of these stars that are rail thin. And so with anything, we have this, there is a need, as Brandon said, a tool. Everything is a tool, but that tool can be taken to extremes. So we're seeing that in the weight loss world right now with people that are really pushing this frail, very, very thin, scary frame. So I think when we talk to midlife women who have, most of them, I'm sure all three of us are in the same boat. Most of them have been dieting for a good amount of their life. Not dieting right because we didn't have the information and we didn't have podcasts and online social media to really get good information and decide what works.

26:46So you have women coming in here and I see it in two camps. I see women that have perpetually dieted and are thin, but not liking their body composition. And they're kind of like, well, where do I go from here? Because if you're going to tell me to sit and prime my body for a year, I'm going to say no. So there's that conversation of why we don't want to push any maybe rapid fat loss to these people that they are the, probably the ones that want it, even if they don't have a ton. And then we have more overweight, maybe even to, into obese women that where the pro like the rapid fat loss might make more sense.

27:29Um, it's maybe a little bit safer, even if they have been quote unquote dieting, um, or try different things throughout their life, very different conversations for the same age woman, say 55 year old, that is slightly obese versus someone that has 15 pounds. And it's just a little bit as they would say, fluffier, just not happy with body composition, but they're doing all of the things. And they're probably the ones. How do you gauge those conversations with something that as we know in literature, we've covered in one of my groups and I had Bill Campbell come on and talk about it. And then it kind of went the wrong way because then everyone was like, well, I want the, I want the fast, rapid fat loss.

28:14Why aren't we all doing that? Why did you bring Bill Campbell on and then say, well, but the group's going this way. So I learned a lesson there, but curious your thoughts. Cause I know we had a little chat about this offline with that subject. I'll let you go first, Brendan. All right. So I'm going to be the king of caveats here because I work with lean women. Good. That's what we're trying to do. Nuance. Tyler Reddick here from 2311 Racing. Victory Lane? Yeah, it's even better with Chumba by my side. Race to ChumbaCasino.com. Let's Chumba. No purchase necessary. VTW Group. Void where prohibited by law.

28:50CTNCs. 21+. Sponsored by Chumba Casino. So first and foremost, let's define a protein-sparing modified fast and then rapid fat loss. So a protein-sparing modified fast is, as its name implies, a high-protein diet that lacks carbohydrates and direct fats, essentially. So we are looking at lean protein sources plus veggies. And then if we kind of go and transition to rapid fat loss, rapid fat loss was developed by a friend of mine named Lyle McDonald. He wrote about this in 2005, and he was kind of the one that brought this to the forefront. If you guys are interested, please go back to Chasing Clarity.

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29:19I've done a three-part podcast with him in depth on this topic. Now, rapid fat loss was conceptualized as a crash diet, but doing it in the right way. That is what Lyle came to. And really what it is in the foundation of the diet is a high protein intake from whole food sources because a lot of the early PSMFs that were in the literature were liquid diets. And there was actually one that was basically collagen based and people died from this. So it was called the last chance diet. And what they meant by that initially was it was the last chance to lose weight. Well, people actually died. So it was their last chance at life, essentially.

29:48So we have to take into consideration the nutrient deficiencies that can come from this. So what rapid fat loss was conceptualized to be and how I apply it in practice is a very large and assertive deficit that is created through a high protein intake that is often to the 1.5 grams per pound per day. So we're in that 3.2, 3.3 grams per kilogram per day. And we are reinforcing that with vegetables. So we have nutrient density, vitamins and minerals, and then we're back filling that with omega-3 essential fatty acids. So you have all your nutrients covered. You have essential amino acids from whole food protein sources.

30:19You have your vitamins and minerals from, and sometimes we will include like, I'll personally include some fruit in the diet, but we're looking at no starchy carbohydrates essentially. And then we have omega-3 essential fatty acids. So you have EPA and you have DHA. Now, rapid fat loss is supposed to be over very short time periods. If you look at the initial writing of Lyle, it was seven to 14 days. Where that has been brought to an extreme are people that are doing months and months and months of rapid fat loss. So you take yourself, and if you guys are familiar with the energy availability literature, In 2023, the IOC, the International Olympic Committee, put forth a new consensus statement on REDS, which is relative energy deficiency in sport, and they delineated low energy availability.

30:59There's problematic low energy availability when it's sustained for a long period of time. And particularly in women, we see a knockdown of the HPO axis. You have low estradiol, low progesterone, you have low thyroid hormone. You have all these downstream implications, low bone mineral density. There are many physiological ramifications of that, but then we also have adaptable low energy availability, which would be the context of someone in a fat loss phase or a very short-term rapid fat loss study. So Bill Campbell's study is at a 37.5 % deficit for two weeks. So you're getting in, you're getting out.

31:27And that can be a tool. And that is something that I utilize with clients. But in practice, we have to delineate who is that right for. And what I have found, I've done about six hours worth of content with Lyle on this. The people that contacted me about this were the people that this was least appropriate for. It was a lean woman trying to get leaner, the person with a chronic dieting history, if we look statistically between 42 to 60 percent of US adults around the world are dieting each and every year. There are many people, if we actually look into the micronutrient, the vitamin and mineral analysis literature, many people are deficient in zinc, iodine, selenium, vitamin D.

32:00These are all things that are cofactors for hormone secretion and conversion, such as testosterone secretion. And then also particularly with thyroid and women are five to eight times more likely to suffer from thyroid disorder. 12 % of women around the world will have some type of thyroid disorder, whether that be Hashimoto's, which they're up to 60 to 75 % of cases is women, or they're going to suffer from hypothyroidism. So we have to delineate, is this appropriate for you? We have to look at lab work first and foremost. So I'm leading with that. And secondarily, we have to look at your starting body fat percentage.

32:27If you're a woman that's close to like 20 % body fat, you don't need rapid fat loss. If you want to get a little bit leaner, we need to take a more sustainable, conservative approach to protect not only your muscle mass, but your bone mineral density, especially as you get into your 40s and your 50s, and then also your hormones. And so where rapid fat loss is very advantageous is if someone has excess adiposity or they have something, and I'm going to be completely honest about this. I have a lot of people that were physique competitors or they were photo shoot preps people, or they had a wedding coming up, or I used to work with a lot of people that they were musicians and they had a music shoot that came up last minute where they were working.

33:03I worked with a lot of people in New York that were actors. Those are things that we would use that for a very short-term basis. Seven days of rapid fat loss, get into a massive deficit, make sure that we're keeping the resistant training stimulus there. We're not doing excessive cardio because that would actually increase the essentially low energy availability state that they're in. But we're doing it. We're getting in, we're getting the fat off, and we're getting right out and back to maintenance so that we can restore the metabolic adaptations that have been sustained through that aggressive deficit.

33:29But protein has to be kept high. Your essential vitamins and minerals, your omega-3s, your essential amino acids, and your vitamin and minerals have to be covered. This cannot be a shake diet where you're just going to drink protein shakes all day and try to lose weight as quickly as possible. And honestly, a lot of times what I'm seeing are people that have such massive appetite suppression from GLP-1s when they're doing rapid fat loss. It's more so not like the structured approach that I'm speaking about. They're just rapidly losing weight. And it's a lot of tissue coming from lean mass and some coming from fat mass.

34:00Okay. Before you answer, Mickey, Brandon, that was amazing. And I love how you talked about, was it, did you say adaptable, low energy availability? We have two terms now. We have adaptable, which would be, I'm going to give you a couple of examples. And they use this in the literature. This could be someone in a fat loss phase. It could be an athlete getting ready for a weight making situation, or it could be someone that's getting ready for an event, a photo shoot, a wedding, a vacation. This is short term. It can be chronic. Now, when you go months in and months out in low energy availability and an aggressive deficit, that's where we see a knockdown effect to your HPO access, to your thyroid hormone to your estradiol, to your progesterone, then it goes downstream.

34:36When estradiol falls, your bone mineral density is going to lower as well. And then we also see immunological effects. So people are getting sick more often, getting upper respiratory infections. You see this a lot in the endurance athletes. You see shin splints, bone breaks, things of that sort. Yeah. Okay. Mickey. Yeah. No, I love that, Brandon. I love hearing how you use it in practice. And I think, and it's quite different as to how I use protein sparing modified fast in practice, actually. So So I use it from a calorie cycling perspective, actually. So in the literature and when we think about rapid fat loss, as Brandon said, it's sort of you're in and you're out and it may be several days sort of strung together or a couple of weeks, et cetera.

35:17Whereas I use protein sparing modified fast as a way to drop calories and create a deficit across a week in an otherwise sort of eating it maintenance style week. um is the calories on the other days would probably be lower than the maintenance but essentially it's only ever one day where you're doing protein sparing modified fast and you're following the guidelines that brandon suggested um or not suggested i'm sorry that brandon sort of detailed as to what that actually entails and then the other days are the type of diet that we would all be sort of recommending that people follow so and the reason i use it actually and Hayley I think both of you know this about me is that you know I don't I don't utilize calories um I haven't utilized um calories in terms of macros if you like um with my clients for like probably 25 years of my clinical practice and I think it's just because my training in nutrition science didn't lead me down macro counting the same way that personal trainers get a macro sort of counting education when they do their courses so that's just not the the training that that I had uh so so my sort of foray into calories and counting and utilizing with small pockets of the people I work with is relatively new so what I found is that in order to this was an a a way to create that deficit without having to overly think about it and overly sort of restrict on every day of the week actually so it's a it's a form of calorie cycling And then in addition to that, the groups that I run, I also like to have like a diet break, essentially, sort of every couple of weeks where we lift calories up on three consecutive days.

37:02Those calories come from carbohydrate. People get what I call a metabolic reset meal and what Brandon would call a free meal. And we essentially practice being at what could be considered maintenance. And I know, Hayley, that we run these and you run these in your groups as well, because, of course, a lot of the issues around fat loss isn't necessarily that they don't know how to diet, it's that they don't know how to keep it off because they've never practiced eating in a way that actually allows them to maintain their weight. and so it's just trying to sort of override their fear of eating more um but obviously in the context of eating less with those protein sparing modified fast days that are sort of that are tiered sort of one two or three days of a week but non-consecutive so so that's how i use protein sparing modified fast just as a as a calorie cycling tool i love it i love how different both of your like similar, but different ways that you use it.

37:58And I would say what, what popped out to me is, um, a couple of things, but number one, that just from, this is from my experience from the groups that I have worked with. And I would say calorie cycling it in more like that seems, more doable for the groups that I work with. I love the other version of like, get in and get the heck out. That to me says you have to work with a coach because most of these women don't know what's going on. They're not getting blood work in large group settings. I mean, I couldn't recommend that just because you need more information. But man, I mean, I would be sending people to Brandon for that.

38:46Haley, if you, if you would let me expand, because I have another take on this and another approach, to be honest with you, I run something called rapid fat loss days. And this is an integrative approach that I utilize where I stair-step someone into a larger deficit just on their off days, but very similar to Mickey. And I think Mickey, we had talked about this when we detailed my own fat loss phase. So this is how I diet myself on training days. I really, my philosophy around nutrition besides like the bioenergetics and biochemistry of nutrition is I want to match the energy demand, like from a nutritional perspective, fuel.

39:17I always say this from James Morton, fuel for the work required. So I want that my energetic status of what I'm taking in from a nutrient perspective, both in a macronutrient perspective, and then also in a total energy intake perspective matches the activity I'm doing. So when I have resistant training days, which is a glycolytic activity that relies of a carbohydrate metabolism, I have higher carb days and I have lower fat days. And then But on my non-training days where I leverage more steps, I leverage more low-intensity activity, especially in a fat-set state so I can mobilize free fatty acids and burn them off for energy, I utilize a very low carbohydrate, higher fat, and then a very high protein diet to really increase that.

39:50And I will often stair-step people from a normal diet that's just a non-training day and a training day where it's essentially a high-carb day and a moderate-carb day. I will essentially transition them when I need to get extra fat off them. I will transition them into one day per week that's on a non-training day into a rapid fat loss day. And that's what I call it. And it's high protein and it's the same conceptualization. Sometimes I'll start with fruit at two or three meals per day, especially before bed, because I want to restock liver glycogen. So especially women can sleep better at night because that's something I find in women between 40 and 55, they have a lot of sleep issues.

40:20And that often comes due to the fact that liver glycogen is essentially falling and they're getting like an adrenaline dump and a cortisol release in the middle of the night. But I will start with say four meals of protein with veggies. Two of those meals will include fruit and I'll have omega-3 essential fatty acids at those meals. So I'm driving a much larger deficit on those days, but they're not, they're not working out. So they're not getting taxed from an energetic perspective. And then if that person has Tyler Reddick here from 2311 racing victory lane. Yeah. It's even better with Chumba by my side.

40:50Race to chumbacasino.com. Let's Chumba. No purchase necessary. VTW group void where prohibited by law. CTNCs 21 plus sponsored by Chumba casino. More body composition goals, or they have a closer deadline, I will walk them into that. And basically I have a lot of clients training between three to five days per week. Eventually the highest amount of rapid fat loss days they'll have is the highest amount of non-training days that they have. So say someone's training four days per week and we really have to get fat off. And we really want, I really want to preserve that, that training day diet. I will leverage those rapid fat loss days on non-training days.

41:20So they'll go from say three non-training days that were normal, moderate carbohydrate. I'll, I'll take one of those out and I'll add in a rapid fat loss day. So high protein, low carb, low fat. And then as we go through the diet, I'll leverage two and then we'll go to three, but I'd never let them first. I don't like them sequential just personally, where they're one after another, because then I start seeing people really struggle with hunger. And then also from an adherence perspective, you can do one, one, you could go low calorie for one day. Anyone can do that because the next day you have a training day diet.

41:46But if I told you, Hey, Friday through Monday, you have to do this or Friday through Sunday, you have to do this low calorie diet. That's a protein sparing modified fast. Most people want to stay on board. So I actually usually dose them throughout the week and I make sure that they're not on weekends. So it usually looks like Monday, Wednesday, Friday for the maximum of three rapid fat loss days per week. And say that I was able to induce a 1500 calorie deficit on those days. So three days per week, I induced a 1500 calorie deficit. That's 4 ,500 calories. So we're looking at one in a third pound of fat loss or even more.

42:13So much to think about. I mean, I love both approaches and just to wrap this up, because I don't want this to get missed. I'm loving the adaptable low energy availability. mainly because the women coming in to a lot of my groups are terrified of low energy availability. Like after two days being in a diet, I'm feeling really low energy. I think I'm in LLEA. And that's a hard conversation too, because we have to be in low energy to lose weight, right? Yeah. But I think we have to delineate between energy balance and an energy deficit and low energy availability. So if you would let me explain the two.

42:57So energy balances is calories in versus calories out. So if you're in an energy deficit, you're essentially expending more energy than you're consuming. And that's just colloquial. We know calories in versus calories out. Low energy availability is a knockdown effect where you are under an energy availability threshold. And initially, Lauchs and colleagues had termed that 30 kcals per kilogram of fat-free mass. So the calculation for low energy availability is you take your exercise energy expenditure and you divide it over your amount of fat-free mass, how many kcals per kilogram of fat-free mass do you?

43:27So it's only muscle metabolism and it's only exercise. Most people, A, are not burning enough in exercise to really be in low energy availability unless they're an endurance athlete. They're doing copious amounts of activity. Really, when it comes to resistance training, if you look at the literature, there's a great study, I believe, by Lidl or Lidl and colleagues that looks at the energy expenditure of an exercise session. And for women, it's around 1.6 to two calories per minute. Because remember, resistance training is an intermittent activity. You rest more than you train. Think about it logically.

43:54You're taking two, three minutes rest or even 90 seconds. Your actual exercise durations of your contractions are much less. Not a lot of calories. Not a lot, but endurance athletes can really rack it up. So Haley, someone like yourself or Mickey, both of you guys would be more susceptible to low energy availability. And we see that in the endurance literature. We don't see that as much in the resistance training, except this is the caveat here. If you look at female bodybuilding contest prep, when you're the combination of very low body fat and very low energy intake for the amount of muscle that you have leads to low energy availability, but it's over a sustained period of time.

44:22First and foremost, we don't really see harmful effects. Mickey, you could speak on this better than I can, but Jose Aretta is actually doing studies looking at what are the effects on muscle metabolism, on muscle protein synthetic rates of short stints at low energy availability. And we're seeing no knockdown effect on muscle. We're seeing no knockdown effect on mitochondrial changes. So that would be what we would term adaptable LEA. To be in true low energy availability, you will feel it. You will have cognitive issues. You have - Oh, I've felt it before. It sucks. You have - Yeah. The first leading indicator is usually menstrual cycle irregularity.

44:55So once you start seeing you're not having between a 21 to 35 day cycle and you start extending out to oligo amenorrhea, so 45 days, where you start seeing you're missing multiple cycles and amenorrhea in and of itself would be termed or would be classified as three months or more, three cycles or more without your menstrual cycle, you're in low energy availability. Now, the caveat here is that psychological stress can actually knock down your HBO access and can cause amenorrhea. But in most cases, for very active women, under-consuming calories, under-fueling themselves. So when I talk about it's not being in an energy deficit, you are under-fueling yourself for the amount of activity, exercise, and body fat percentage and muscle mass that you have, that would be low energy availability.

45:32Most women, if you have excess adiposity, you're skinny fat and you're in an energy deficit and you're not losing, say, more than one pound per week, you're not an LEA. Okay. Yeah. And I just will just say, it's that people hear a term and they're like, oh, that is me. That LEA, I want to avoid that. We love to identify with a term. Absolutely. Sorry, Hayley, you go. No, I was just going to say, and that is the difference right there, is that the majority of women, at least that I'm working with, are not endurance athletes. Some of them are, but not the majority, by far, not the majority. They're exercising for maybe 30 to 60 minutes most days, three to six days a week.

46:19If they're not in this aggressive deficit for weeks or it's that energy balance, really under eating, over exercising, that applies to endurance athletes, elite athletes. I felt that on a couple of these, a little bit on these rides of the last few months from what I've been doing just because I'm not used to training this much anymore. And I wasn't intaking the food because I'm sitting up in my attic doing work all the time. And so it was really hard for me. And I definitely know, I mean, I've had times in my life where I felt that way, but on average for the average female midlife that has some, most women are coming that maybe have 10 to 30 pounds, maybe 40 pounds to lose.

47:11They're only exercising most days, but not every day. And they're exercising for about 30 to 60 minutes. Probably don't have to worry about low energy availability. I'm in complete agreement. And it's, it's very similar to overtraining syndrome. People say that all the time. If you actually look in the clinical literature on that, you have more of a likelihood of getting struck by lightning than you do over training syndrome, especially from a resistance training perspective. Oh, yeah. Yeah. I mean, in the resistance training. Yeah. I mean, as you said, the calories, it's not a lot. It's not a lot.

47:42But that's not why we do it. So moving on to spot reduction, and we're for sure going to need a part two. Tyler Reddick here from 2311 Racing. The rush of racing? Nothing beats it. But Chumba Casino comes close. Chumba's got fast spins, fun games, daily bonuses, and all the action you can handle. Now that's a ride. Ready to hit the throttle? Get in the driver's seat and head to ChumbaCasino.com. Let's Chumba. Sponsored by Chumba Casino. No purchase necessary. VGW Group. Voidware prohibited by law. 21 plus. Terms and conditions apply. This is going to be a long one. There's a lot of nuances. I've got, this is all the question number three.

48:26Okay. Go ahead. Spot reduction. I know Mickey, you have recommended Brandon or you've referred to Brandon on some of our courses. And this is the question that always gets brought up. So the nuances and everything, because again, I don't want women to just hear and be like, okay, cool. I'm spot reducing. And where's your program, Haley, that spot reduces X. Insert whatever you want. So Brandon, tell us what that is as far as how you see it, what you do with it, what you know about it. Go ahead. We want to hear it all. All right. Haley, you had asked me off here, what was maybe a controversial take that I had or something that I just didn't agree with the industry on.

49:15And this is one of my primary ones. It's spot reduction. And I think that there's been a mis-extrapolation of the research and a misinterpretation. And I also think that definitionally, we're looking at two different things. So if you were to ask most people in the fitness industry, what spot reduction is, they would tell you, or they would probably spout out something to the effect that you can target and lose fat from one specific area by simply exercising that area. So a great example is if you do more crunches, you'll lose L.A. fat. Or if you do enough tricep extensions, you'll lose fat on the back of your arms.

49:44And I will tell this straight up, that version of spot reduction is still a myth. You're not going to sit up your way to a slimmer stomach. You're not going to do a single exercise in isolation enough to produce noticeable fat loss. Now, how I actually define spot reduction based on the clinical literature is differently than most. And I define spot reduction as the potential to preferentially lose body fat from a specific area by combining localized resistance training for that region. So let's say for the arms or for the abdomen, and then combining that with cardio after and making sure that you have a sustained calorie deficit.

50:16And I think that's where it really gets delineated because a lot of people are looking at the old literature. So for instance, if you look at the original studies on this, it's in the 60s and 70s. And most of them were examining isolated resistant exercises that fail to demonstrate meaningful fat loss in that area. So a great example of this is there was a study on tennis players essentially, and they were looking at the trained arm or it wasn't trained, but essentially the arm that they played on versus the other arm. And all they found was that the arm that was trained had more muscle mass, but the same amount of subcontinuous body fat.

50:48The same team can be said they did a massive crunch study back in the day. It was like 2010. And they found that even with like 30 minutes of crunching per day, they were not losing preferential abdominal fat. Now, if they were able to sustain a deficit, they were able to lose some type of fat. Now, when it comes to actual spa reduction, when we actually look at some of the more updated literature, we see that we actually can spot reduce, but it takes a multimodal approach to this. And so that's really where my approach or my stance on this has changed because I think that a lot of, there's a confounder here.

51:20A lot of the people that say just colloquially spot reduction is myth. They are referring to old literature first and foremost. And secondarily, they have not looked into the most recent literature. So I'll give you guys a couple of examples of some of the limitations of the early research and why I don't share the same perspective as many people in the space. So first and foremost, the most of the literature that came in the 60s, 70s, early 2000s, they only tested one type of exercise. So that was usually high repetition, localized, resistant training, like crunches or unilateral training. They would train one arm, they would train one leg.

51:51They didn't combine that localized resistant training with aerobic exercise. The other thing is we have to realize what is going on from a physiological perspective. Let's talk about fat loss physiology. If you are exercising a limb, you're only mobilizing fat. So you're getting fat out of fat cells. So essentially, the process of lipolysis, which is breaking stored fat in the form of triglyceride down into free fatty acids and a glycerol backbone that can happen from resistant training in and of itself. But if you have nothing to oxidize, to transport and oxidize those free fatty acids, you can't lose fat.

52:22You've just liberated fat. That's going to get restored through a process called re-esterification. And then the other thing is, if you look at the original research, none of it had dietary control. They let people eat their regular diet. And here's the thing, A lot of these were done on untrained people. And we know just working in practice and we can see in the literature for most people that have began exercising, many are going to unconsciously increase their food intake. So they're going to get into a surplus and no matter what you're doing, whether you're doing crunches for all day, where you're doing tricep kickbacks, you know, until the cows come home, if you're in an energy surplus, you're not losing body fat.

52:52So it doesn't matter. So really when it comes down to it, I think that many people have misunderstood the spa reduction, like what it is from a myth perspective. And then also what I find with a lot of individuals is that they don't understand fat loss physiology. So they don't actually don't know the process in which the body needs to go through to burn fat because they think about fat, like it just gets burnt. And that's really not the process it goes through. There is a three steps, three step process, which includes lipolysis, transport and oxidation. And so really what we need to do, and this, this applies to every single context, any body fat that you want to lose, you have to go through this process.

53:26You need to go through lipolysis, which is breaking fat out of a fat cell. and that is going to be stimulated through catecholamine release, which is noradrenaline and adrenaline. And the things that do that are exercise, especially high intensity exercise. So if you do resistant training or HIIT training, a calorie deficit is going to increase catecholamine release. And then certain stimulants, you can use caffeine. There's other central nervous stimulants that you can use that are going to increase catecholamine release. But all that's doing is getting fat into the bloodstream. Now, what we have to realize is that does not mean that you're losing fat in that area.

53:54You have to go through a second process, which is called transport, which is where you take those free fatty acids, you take them through the bloodstream and then you deliver them to the oxidation process. And one way that we increase blood flow is through training, through exercise. It increases localized blood flow. So if you get a local contraction, say that you want to burn fat in your abdomen, you're going to have to work out that area to increase blood flow, especially because if you especially look at the low abdominals where a lot of men hold visceral adiposity, that is an area with really poor blood flow.

54:21It's not really hot. It's not other areas like your limbs, which are usually vast, veiny and they have good vasculature and good blood flow. So you need to do exercise to transport those nutrients. And then you have to go through fatty acid oxidation or beta oxidation. And that is where fatty acids are delivered into tissue like skeletal muscle. And the way to do that, the whole process is going to require exercise to liberate that or supplementation. Then you're going to have to do something like low intensity aerobic activity to burn off those fatty acids to be able to actually lose fat. So I think that a lot of people don't understand the actual full process and what it actually takes.

54:56And we have updated literature that actually looks at. Tyler Reddick here from 2311 Racing, another checkered flag for the books. Time to celebrate with Chumba. Jump in at chumbacasino.com. Let's Chumba. No purchase necessary. BTW Group. Void where prohibited by law. CTNC 21 Plus. Sponsored by Chumba Casino. You know, the process of spot reduction and how using a multimodal approach can actually elicit spot reduction. Now, before I go into that, I want to throw it back to you guys and see if you have any questions regarding that. I've got a whole bunch, but we don't have time for all of mine. Vicki, go ahead.

55:31All I will say is just that I've learned so much from Brandon about the whole spot reduction process. And Brandon and I have had some back and forths because I guess it's not a caveat, but it's something just to consider that if you're someone who has lipoedema which is um fat storage sort of uh that is sort of inflamed fat tissue typically in the lower limbs um that is fibrotic and a lot of women i say a lot of women but up to 10 percent of women do have lipoedema and and it's very that is a different condition and doesn't it may respond it doesn't respond the same way as normal fat tissue does to sort of losing body fat And the one thing that I will add, I'm sure Brandon would say it, is that high-intensity work post the resistance exercise won't allow for that same spot reduction effect because it increases glucose in the bloodstream and will suppress that fat oxidation.

56:36So it has to be low-intensity exercise. But I, of course, learned that from Brandon as well. yes i okay i love that uh delineation so that it because that could get confusing too with the intensity type but okay so if we're to like i said i i would love to invite you both back on because i feel like we barely got through a great conversation and i feel like we nailed all of these big issues but man i'd love to have a whole other two hours with you well consider it done. We'll make it happen. So if we were to wrap this up and we're talking about, obviously, I only care about midlife women in this phase and they're listening to this podcast and they're like, okay, cool.

57:25Some great points. They're probably following all of us anyways, but kind of still feel like where, what, where do they start? Like what, what, where do they start and where do they go without feeling overwhelmed as a midlife female that desperately wants result? And, and, and we'll, let's just go for body composition. Cause I know everyone wants muscle, but most of the women that are coming to us probably want a little bit of fat loss as well. Yeah, absolutely. So in the context of spa reduction, that's not going to be the first lever that I pull. That is something that is most applicable for people once they get leaner and they also have to already induce and sustain a calorie deficit.

58:08So the first thing I'm doing, I'm a nutritionist first and foremost. So I take a food first approach. So first thing we have to dial in your nutrition, we have to create an effective calorie deficit before anything. And I like really using the scientific method. I like isolating each variable by itself to see engage someone's response. So before I do anything, and we're just going for the goal of fat loss, before we put the bat wings on, you know, you know, the underarms under the scope or your belly fat, whatever it may be, we're going to focus on creating a calorie deficit before we do cardio, before we do step count or supplementation.

58:37Once that deficit is established, then I start layering in other principles. So first and foremost, I'm going to get that person to tell me what are the stubborn areas that you want to work on? And if they have a specific area that they want to improve, I have to make sure that they're training it directly. And it's going to be in a very specific way, but I'll just give you a broad base overview. If it's their midsection, they want a tighter abdominal, they want tighter abs and leaner abs. We're going to do direct abdominal training. If there are triceps, which a lot of women tell me, so that's why I'm giving that specific example, we're going to make sure that they're progressively training their triceps.

59:06And if it's their low back, we're going to do back extensions and things of that sort. Now, the thing is that I'm using resistance training with the goal of providing a localized stimulus that increases blood flow to that area and helps that fat mobilization process. It's going to turn on that lipolysis process. So what I'm trying to do is just get fat out of that fat area. Obviously, if you have excess fat in your low back, your low abs on your triceps, on the back of your arms, we need to get that out. So first and foremost, we're trying to liberate that. And then right after that, we're going to go into some steady state cardio.

59:32And really what we're doing is looking, like Mickey had mentioned, the different modalities from an energetic perspective of what energy substrate is he using. And also if we look like bioenergetics, like what is he doing? Resistant training, high intensity. So it's working off aerobic metabolism, but it's going to have that increase in catecholamines, which are going to bind to those receptors and liberate free fatty acids from that fat storage. Then we're going to follow that with low intensity exercise because it relies on that metabolism in and of itself. So that's going to help. We've already mobilized fat out of the fat cell during the resistance training session.

1:00:02And then we're going to use that lower intensity exercise to burn off those free fatty acids while they're in circulation. Now we're going to do that combination, but I have many, you know, we would have to really get into nuances, like all the approaches that I take, but really if I was to say, Hey, what is the basic thing? Let's get you an energy deficit. Make sure that you're actually losing fat effectively. Secondarily, I'm going to tack on some extra work at the end of your session to increase localized blood flow to that area and make sure that we're burning off. So I will do this actually with a high frequency.

1:00:30This is not going to be a once per week that we're hitting your say glutes for a woman. It's not gonna be once a week that we're doing this. I will do some type of isolation type exercise with a very high rep ranges to increase blood flow and vasodilation to that area. So it could be, I'll give you an example, glute bridges. If a woman has extra fat off them and she wants to lose fat in the area, we're going to do high rep glute bridges. And to, you know, we're talking 50 reps sometimes. And so we're going to do a few sets of that. We're going to increase localized blood flow to that area. We're going to increase that mobilization from those fatty acids in the glute tissue, the gluteal femoral area.

1:01:04And then right after that, we're going to go do some cardio and we're going to do that on a frequent basis. I also have some strategies that we have to get into because they're very nuanced and I don't want to just throw them out there, but there's specific supplementation. There's some facet training type of modalities that I utilize. These are all things that I've seen work in practice. And you can even look, I have transformations where I've literally done this, where I've done it in practice. And this all comes from in the trenches. I read the literature, but it really came from me testing these things with myself and with other clients and then going back into the literature to find the physiology to reinforce it.

1:01:33So this is not just like an evidence-based perspective, but it's also, hey, I have clients that come to me that are super self-conscious about the fat under their arms or their glute fat or their low back fat. I had to find a solution. And that's why I take a different stance than others in this industry. It also took me an immense amount of time to comb through the literature and actually get a great understanding of it and then break this all down in a simple fashion. Really, when someone's able to explain something simply, it's because they know it to an extent that most people can't conceptualize.

1:01:58Okay, Mickey, your take. And then I want to cover one question at the end of I'm barely eating enough, but I'm not losing weight. And what your thoughts are on that question to end. Yeah, I love it. And in fact, Hayley, I think I could probably encompass that question with my answer to the previous question that you had because I just, I stepped back and think, I just thought really big picture. I think a lot of people think they're doing the right thing. So they hear the problems that everyone has, that they need to eat more protein, that they need to have more fiber. They have to start exercising more.

1:02:30And these are all likely true, but to add nuance and context, you actually have to think about yourself and have awareness of your own habits and behavior. So my almost very first thing that I like people to do is, it's really simple, but can you just keep a food diary for three days. And actually write down everything you eat at the time that you're eating it, how you're feeling when you eat it, how full you feel, how hungry you are going in, how full you feel going out, and get them to have some awareness of actually what they're doing on the food front. Because sometimes they're trying to solve a problem that isn't really there.

1:03:08But they think that what they need to do is have better snack options at three o 'clock because they keep diving into the chocolate, whereas actually what they need to do is probably eat more earlier in the day so they're not needing a snack at three o 'clock. And it's not until we bring this awareness to their habits and behaviors that we actually are able to then sort of pinpoint how to implement all of the best practice stuff that we talk about all of the time with people. So that was sort of my take on your question, Hayley. And I think that also probably answers that your last question as well so and I know that sounds like people get impatient with change they just want the answer immediately but you just don't know if that's correct for you in your situation until you're aware and as we know from the literature we might be aware of 10 % of our food decisions because we run on autopilot all of the time like the things that you just aren't aware that you're doing is way more than those sort of most deliberate and conscious decisions you make around food.

1:04:13Wow. Okay. Well, what a way to wrap it up. Brandon, Mickey, thank you so much for joining us on the BodyPod for this roundtable discussion. I have loved it. And I really hope that there is another one in the future. Thank you so much, Hayley. Thanks for listening, everyone. If you enjoyed this episode, please consider giving us a five-star rating and sharing the BodyPod with your friends.

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From the publisher
If you're a midlife woman trying to build muscle, lose stubborn fat, and finally get straight answers about protein, this episode of The Body Pod is required listening. Host Hailey Babcock sits down with nutrition scientist Mikki Williden, PhD, and nutrition coach Brandon DaCruz to tackle the online protein controversy head-on: is there really a "ceiling" of 1.6 grams of protein per kilogram of body weight, or does that number change entirely once a midlife woman is strength training and eating in a calorie deficit? Drawing on a 2025 meta-regression on protein dosing, Bill Campbell's body recomposition research, and decades of clinical experience, Brandon and Mikki break down exactly how much protein women over 40 need to protect muscle mass, support bone density, and build a body recomposition: losing fat and gaining muscle at the same time.

The conversation goes far beyond protein numbers, digging into the fat loss strategies every midlife woman should understand before trying them. Brandon explains protein-sparing modified fasts and rapid fat loss protocols — including who they're genuinely appropriate for and why chronic dieters and lean women trying to get leaner should approach them with real caution — while Mikki offers a more sustainable alternative using calorie cycling and diet breaks to create a deficit without the burnout. The two also unpack the real science behind spot reduction, walking through the physiology of fat loss (lipolysis, transport, and oxidation) to explain whether targeting fat loss in the abs, arms, or glutes is actually possible.

This episode also confronts the hidden hormonal risks of chronic dieting in midlife, including low energy availability, thyroid dysfunction, and declining bone mineral density, referencing the IOC's 2023 consensus statement on Relative Energy Deficiency in Sport. Hailey, Mikki, and Brandon also touch on GLP-1 medications, muscle loss, and the pressure many women feel to be "rail thin," closing with Mikki's simple 3-day food journal exercise designed to reveal what's really stalling fat loss progress. Whether you're navigating perimenopause, menopause, or just tired of conflicting advice, this roundtable delivers the nuanced, evidence-based guidance midlife women need to build muscle, lose fat sustainably, and protect their long-term hormone health.

If you love what you learned in this podcast, Mikki Wlliden is one of the featured experts in our Fat Loss Happens Education course starting September 8th. Join now for our 7-week science-backed education program that teaches midlife women how to lose fat, build strength, and keep results, without extreme diets or endless cardio.

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Finish 2026 Strong. Two expert-led ways to close out the year, each with a community of women learning and training beside you. Be first in line → when we open doors for early access to Fat Loss Happens Education course and the Shred Happens challenge.


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