In short
Podcast Summary: The Diary Of A CEO with Steven Bartlett
Episode Title
The Groundbreaking Cancer Expert: (New Research) This Common Food Is Making Cancer Worse! Cancer Is Getting Worse Worldwide & It Might Not Be Genetic, It's Your Diet!
Host
Steven Bartlett
Guest
Dr. Thomas Seyfried
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Episode Overview
In this episode, Steven Bartlett interviews Dr. Thomas Seyfried, a Professor of Biology, Genetics, and Biochemistry at Boston College, focusing on the metabolic aspects of cancer. Dr. Seyfried challenges the traditional genetic theory of cancer, suggesting instead that cancer is a metabolic disease influenced significantly by diet and lifestyle. He discusses the role of blood sugar, stress, and lifestyle choices in cancer growth and prevention, advocating for a metabolic approach to cancer treatment.
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Key Topics Discussed
Introduction
- Dr. Seyfried's Role:
- A professor focused on cancer research, specifically its origins, management, and prevention through metabolic theories.
Global Cancer Overview
- Cancer is increasingly prevalent worldwide, with millions of new cases and deaths annually.
- Predominant types of cancer include lung, pancreatic, breast, and colon cancer.
Cancer as a Metabolic Disease
- Warburg Effect:
- Cancer cells rely on fermentation (energy production without oxygen), a process stemming from defective mitochondria.
- Dr. Seyfried's Argument:
- Cancer arises from mitochondrial dysfunction rather than genetic mutations.
- This dysfunction leads to an increased dependence on glucose and glutamine.
Ancestral and Lifestyle Factors
- Examination of ancestral diets shows minimal cancer incidence; modern lifestyle changes have increased cancer risk.
- Lifestyle Factors:
- High carbohydrate intake, lack of exercise, stress, and poor sleep contribute to mitochondrial dysfunction.
Metabolic Therapy
- Ketogenic Diet:
- Reducing glucose via a ketogenic diet can slow cancer growth by depriving cancer cells of their preferred fuel.
- Exercise:
- Helps in reducing blood sugar and maintaining healthy mitochondria.
- Fasting and Calorie Restriction:
- Suggested as methods to enhance metabolic health.
Scientific Resistance and Paradigm Shifts
- Comparison to historical paradigm shifts (e.g., germ theory and heliocentrism).
- Resistance from conventional medical institutions due to economic and systemic inertia.
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Practical Advice
- Dietary Recommendations:
- Consider low-carbohydrate diets to maintain metabolic health.
- Regular exercise to reduce cancer risk.
- Understanding Cancer Risks:
- Environmental carcinogens and lifestyle can increase cancer risk despite genetic predisposition.
Case Studies and Anecdotes
- Dog Study:
- Application of a natural, calorie-restricted diet in dogs showed potential benefits in controlling cancer.
- Human Experiences:
- The case of Pablo Kelly, who managed a brain tumor using metabolic therapy, highlights possible benefits and challenges.
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Conclusion and Future Outlook
- Dr. Seyfried’s Vision:
- A shift towards metabolic understanding and treatment of cancer could drastically reduce cancer incidence and improve survival rates.
- Call to Action:
- Encouragement for personal lifestyle changes and wider acceptance of metabolic therapies in medical practice.
Final Thoughts
- Dr. Seyfried emphasizes personal responsibility in cancer prevention and management through informed lifestyle choices and metabolic health awareness.
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Follow and Support
- Dr. Thomas Seyfried's work can be followed on Instagram and Twitter. Donations to his research are accepted through Boston College and other foundations.
- Steven Bartlett's new book and other related resources are available online.
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Note: This summary captures the essence of the podcast's discussion on cancer as a metabolic disease. For detailed insights, consider listening to the full episode of "The Diary Of A CEO" with Steven Bartlett.
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Transcript
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0:36And over the course of my career, I've learnt just how crucial having the right systems in places, one which has helped me across many of my investments is NetSuite. They're also a sponsor of this podcast. NetSuite is the number one cloud financial system through their streamlined platform. You'll find all of your accounting financial management inventory and HR in one place. Their technology has been a real game changer, especially for my team at Flight Studio. As over the last year, we've moved out of startup mode and into scale at mode. We no longer have to juggle multiple systems and having everything together has reduced the number of manual tasks and errors.
1:11Over 41 ,000 businesses have chosen to future -proof their business with NetSuite. So if you'd like to learn how it can help your business, head to netsuite .com slash Bartlett. And free download the CFO's guide to AI and machine learning. That's netsuite .com slash Bartlett. Cancer is very preventable. When the medical establishment acknowledged what I know about this disorder, what's causing it, and what we're not doing to prevent it or treat it, it'll be recognized as the greatest tragedy in the history of medicine. Thomas C. Freight is a professor of biology, genetics and biochemistry who has dedicated the past 30 years gathering scientific evidence on what could be the true origin and prevention of cancer.
1:48The answer is getting worse and there's no major advance in reducing death rates that I can speak to the reasons for that. All major cancer research centers think cancer is a genetic disease. You believe otherwise. It's not whether you believe it's what the data tells us. And the evidence is massive to support that cancer is a metabolic disorder. And the problem is we're doing everything we possibly can in our lifestyle to induce it. The scientific evidence is there. Like for example, we know that cancer was extremely rare in African tribes that were living according to the traditional ways. But when modern lifestyle entered into their societies, cancer out of control, we even did a study on dogs.
2:24We know that wolves in the wild don't die from cancer. But cancer is the number one killer of domestic dogs. Why? It's because of our lifestyle issues. And a lot of us are doing things without the knowledge that it would put us at risk. But with metabolic therapy, you can use it as both a prevention and a treatment. And we're seeing more and more of hormonal cancer patients outliving their predictability because of this. And let me tell you one thing and remember it. If you do metabolic therapy, you can actually reduce risk for cancer. You can take away the fear. And when you say metabolic therapy, tell me what those things are.
2:54Number one.
3:01Professor C. Fried. If someone walks up to you on the street and they know nothing about science and they know nothing about medicine, et cetera, and they asked you, what do you do and why do you do it? How would you respond? I'm a professor of biology at Boston College. So in that role, I spent a lot of my time working with undergraduates and graduate students in training them to be scientific literate in various aspects of biology. The research program that we have at the university is also focused on understanding how to manage cancer better, how it originates, and how to prevent it. How much of a problem is cancer globally?
3:41What have had line statistics on the macro view of cancer? For someone that really doesn't know? Yeah, well, it's getting worse. I can't say, it's in the millions, I know precisely what's going on in this country because the American Cancer Society, every year, distributes the data on cancer. We have almost two million new cases diagnosed per year in the United States. And we have 1 ,700 people a day dying from cancer in the United States, which comes to about 70 people per hour in the United States. Now, when I went to China, I looked at some numbers there, and it was 8 ,000 people a day dying from cancer.
4:29Obviously, the population is so much larger. And I don't know what it is in the UK. I mean, we'd have to go to their cancer registries. But what we do know is that it's supposed to be a lot worse by 2050 than it is today. So there seems to be no reduction in death suffering for this disease. And I can speak to the reasons for that. But right now, I would say it's a global epidemic of cancer. It's not getting better. It's getting worse. More people are dying from it. There's no major advance in reducing death rates. So it's a great tragedy. And when we understand what's causing it, and what we're not doing to prevent it or treat it, it'll be recognized as the singular greatest tragedy in the history of medicine.
5:18Worldwide, when they come to know what I know about this disorder, and then they realize what we've been doing in a misdirected way, it'll be recognized as the greatest tragedy in the history of medicine. What types of cancer people are dying from? What is the most popular types of cancer for men and women? Well, it's always been lung cancer, pretty much for men and women. Lung cancer has always been the number one. But we have pancreatic breast cancer, colon cancer. These are all on the rise. Colum cancer is on the rise. Pancreatic cancer is on the rise in this country. I can't speak for other countries.
5:55They may vary slightly due to diet lifestyle issues. But lung cancer has always been recognized as the number one cancer. How many people in the United States then based on the statistics would develop cancer? Well, it seems to increase every year, so it's kind of a moving target. It doesn't seem to go down. What it is today, I don't know, but what I do know is the numbers of people that are dying each day. Because the American Cancer Society comes out with, I think it's 612 ,000 people will die this year, 2024, from cancer in this year. So divided by 365, and it comes out to just about 1700 people a day, divide that number by 24, and you get about 70 people an hour.
6:43Based on the numbers provided to us from the American Cancer Society. When they say we've made major advances in cancer incidences, right? So in the 1990s, they instituted the anti -smoking campaigns. So today, if you read, they say we have reduced cancer deaths by 31 or 32%. Wow, that sounds really impressive. So what they do is they take the number. This is what the National American Cancer Society has done and it's published in their papers. If we didn't stop smoking in the 90s and everybody continued to smoke, the trajectory would be very, very high. Because we stopped smoking or this, we have 33 % lower death than if we didn't stop smoking.
7:32But the trajectory is continuing to increase, maybe not as steep as it would have been, had we continued to smoke. So it was clearly a prevention. It had nothing to do with a treatment. It had to do with prevention. That was giving the know -oh, we've made major advances in reducing cancer deaths. Yeah, because people stopped smoking. For many, many people, more people would have died had they not smoked. So we have people that are not real people. We're just looking at what would have happened if we didn't stop smoking. What are the leading causes of death worldwide in terms of diseases? I hear that heart disease is number one.
8:11I think that's, heart disease is number one. Cancer is number two. Okay. And there are many different types of cancer. There's hundreds of different forms of cancer. If you look under the electron microscope or a correction, even the light micro... This is how most cancers are diagnosed by light microscopy. You look under the microscope and you see a bunch of cells that are dysmorphic in the way they look. And then they all have genetic defects and all this kind of stuff. But they all have one thing in common. They depend on a fermentation, energy without oxygen. So all cancers are a singular type of disease.
8:47It's just that they happen in different tissues. But when you look at the underlying problem, they're all very, very similar. They can't live without a fermentation, which means energy without oxygen. So that's the common pathophysiological problem in all cancers, whether it's a colon, brain, breast, bladder, skin, lung. We've looked at all these cancers and they're all... Essentially using the same mechanism to grow out of control. So what is that fermentation you mentioned? Permanentation is energy without oxygen. What does that mean? We breathe air and we exhale CO2 and water vapor. And those are the waste products of the food that we eat.
9:26We breathe, everything is broken down and combusted in our mitochondria of the cell. And the waste products are CO2 and water vapors. Those are the waste products. But if you and I were to stop breathing for any particular pine period, our bodies would fill up with lactic acid and succinic acid, like if we were to have a heart attack or someone somebody has a heart attack. They don't die instantly. If they're there without for five or seven minutes without oxygen, they may die because the brain dies. But if you can get the heart to beat again and get oxygen back into the system, you can come alive again.
10:03But when we have that massive interruption of oxygen into our body, the cells fall back on an ancient, they immediately turn on these ancient pathways to get energy without oxygen for a short period of time. And that's the sugar glucose, which is already in our bloodstream from the food we eat. And the amino acid glutamine, which is a high, amino acid in our bloodstreams, highest level of amino acid is the glutamine. These two fuels are now burned for energy, obtained energy without oxygen. There's no, there's these pathways up regulate and you can get ATP, which is energy. To keep you alive for a short period of time, but your bloodstream is filling up with the waste products called lactic acid and succinic acid.
10:51Lactic acid is coming from glucose to sugar and succinic acid is coming from the amino acid glutamine. And they build up and that tells you you're fermenting. You're getting energy without oxygen because you're not breathing. Very simple, you're not breathing, but I'm not dead yet. Now of course, if you don't get it for very long, you die. It's just that. Now, the other way you can stop oxygenation in our bodies quickly is with the poison cyanide. So if we got for bid, we would take cyanide, we'd be both dead within a minute. Because our bodies are completely shut down of energy from oxygen. Now here's the cancer cell.
11:30The cancer cell lives in, can live in cyanide. The cyanide does not kill a tumor. I don't worry, I showed this a long time ago and we've also shown the same thing in our lab. Others have shown this. The interesting thing is when you look at cancer cells, even in the presence of oxygen, even in oxygen. They're throwing out lactic acid and succinic acid. What does that mean? That means the organelle inside the cell that generates energy is not efficient. It's inefficient and the cells are using an ancient fermentation. And when I say ancient fermentation, you have to realize the earth is four and a half billion years old.
12:11The organisms that existed on our planet two and a half billion years ago were all fermenters. There was no oxygen in the atmosphere until the photosynthetic bacteria started to make an oxygen. They were living cells. They had no oxygen. And they were growing like crazy, unregulated growth. Just unregulated, what's going on here? And they would die as soon as the fermentable fuels were dissipated as they gobbled up everything. They would just die. So they lived as long as they could reproduce and have fermentation fuels. The cancer cell in our body is doing nothing than falling back on these ancient fermentation pathways that become accelerated, upregulated in the tumor cell because the efficiency of the energy coming from the mitochondria is now depleted.
12:55It's defective in many different ways. So this is very clear. And this happens in lung cancer, colon cancer. We've looked at all the major cancers. And we found out these common defects are seen in all the cancers. So they're all very similar in their metabolism. They're very different in what they look like under the microscope. Long doesn't look like colon, doesn't look like brain. They're very different genetically. They're all different from each other. But they're all common in a dependency on this ancient pathway of energy metabolism. Can you take me back? You mentioned a guy called Woolberg that?
13:27Yeah. Can you take me back on the journey that the scientific community, or at least you have been on to arrive at the conclusion that the central sort of causal factor, or at least an indication of the causal factor of cancer lies in this shift in energy systems? Where did this understanding start in research? Well, it started without a warberg for sure in the 1920s. The other linkage before I could tell you what auto warberg did because I was like everybody else. I thought cancer was a genetic disease. And I heard about warberg didn't really know what he was talking about or invested anytime thinking about what he said.
14:03But Lyndon Nebling was a PhD nursing student at Case Western Reserve University in Ohio. And she took these two little hopeless kids, a brain cancer. We call hopeless cases when they have no predictability of long -term survival. And she gave them a ketogenic diet, a lower blood sugar. And she was able to rescue these kids. One eventually died. The other one was lost to follow -up. And she said, her strategy was based on what auto warberg had said about glucose and cancer. So then I said, warberg, I said, who the hell? Let me go back and check out who this guy was and what he did. Because I was seeing similar things in the mouse with that drug.
14:44It was lower in glucose. And we were shrinking these tumor cells. And we published a paper, the first one of the first ever papers, linking that how high your blood sugar is, determines how fast your tumor will grow in the mice. And now how this has been replicated in all human cancers. The higher your blood sugar, the faster the tumor grows, the lower the blood sugar, the slower the tumor grows. Undeniable for all different human mouse cancers. Wow. So warberg had said this a long time ago back in the 1920s. He was taking slices of all kinds of human and rat mouse tumors and slicing them up. And he noticed something really strange about these cancers.
15:24They take in less oxygen compared to the normal tissue from which they came. Wow. So they're kind of like oxygen deprived. And they were throwing out this lactic acid waste product that he was saying. And they were taking in so much more glucose than the normal. So the normal cells taken just a little bit of glucose and they can make tremendous energy from a tiny amount. This guy was taken in huge amounts of glucose, but not fully metabolizing it to CO2 and water, but dumping it out as lactic acid, which is a breakdown product of glucose that is not fully metabolized in the cell. Wow. He said, this is unbelievable.
16:01And then he did all kinds of tissue. I looked at his data. For some believe him. He was cutting humans, mice, rats, and seeing the same thing over and over again. And he was saying the origin of cancer has to do with something in the ability of the mitochondria, the organelle to generate efficient energy from oxygen. So the mitochondria is the part of the cell that creates energy. It's the part of the cell that creates energy through oxidative phosphorylation, which is burning energy using oxygen. Okay. So it's like an engine. It's an engine, a very highly efficient engine. This is an organelle.
16:38You have to realize we have the cell. Yeah. And we have a nucleus that everybody knows about. This nucleus. And then we have all these little organelles in there. We have lysosomes. And we have the mitochondria in which is like a spaghetti network inside the cell. It's actually a second living organism inside ourselves. And to simplify what they do the mitochondria. They convert oxygen and glucose into energy. Yes. And they combust energy. They take the foods that we have carbon hydrogen bonds. Okay. And we break those down inside our mitochondria. And we, and we, and when we break those bonds down, we create a hydrogen gradient.
17:18And we dissipate that gradient through an impeller mechanism that generates energy like crazy. It's unbelievable. Very efficient, highly efficient. But the cancer cell has corruption in that system. But it doesn't happen overnight. As Warburg said, if you break that system too acutely and too fast, the cell will die. It doesn't have the, so you have to have two things to get from oxidative phosphorylation to energy with, with minimal oxygen fermentation. Sorry, just to give it simple, from a normal cell to a cancer cell. From a normal cell to a cancer cell doesn't happen overnight. Okay. It's a chronic damage to the ability of, of that organelle inside the cell to generate efficient energy.
17:59Okay. So all we have to know with cancer is that they're, how are they growing so rapidly? Why are they going out of control? How come it's so hard to kill them? Because as long as you have those fermentable fuels that drive this ancient fermentation pathway, they will continue to grow. They're very hard to kill. And the fermenting fuels are glucose and... And glutamine. Glutamine. Yeah. Okay. So here, let's let me tell you in a nutshell. I read it. Brace yourself. Are you ready? I read it. Are you braced? It's sufficiently bleb -braced. Sufficiently bleb -braced. He's sufficiently braced. Okay.
18:34So, a solution to the cancer problem, to manage cancer without toxicity, is to simultaneously restrict the two fuels that are needed to drive this dysregulated growth, while transitioning the whole body off to a fuel that the tumor cells can't use, which is fatty acids and ketone bodies. So when we take the cancer patients or the mice, we put them into a calorie restriction, lowering the blood sugar, that I said is one half of the two fuels. You can lower that down, really, really low. And then we use specific drugs to target the glutamine. And together, we can selectively restrict the two fuels, while we transition the whole body over to ketones.
19:21We, as a species, evolved to be in nutritional ketosis for the majority of our existence as a species, like one and a half million years, for centuries and centuries, thousands and thousands of years. Our species, you and me, are ancestors. We're always in a state of nutritional ketosis, because there was very few carbohydrates in the environment for them to be consuming. Right? So the cancer cell, the body, you and I, could, if we stopped eating and we took a low carbohydrate diet, just the water only fasting, we would get into nutritional ketosis, where the normal cells, our brain, our kidneys, our heart, can be burning these ketone bodies, because they have a good mitochondria, and they can burn these fuels effectively.
20:05The tumor cells have a bad mitochondria, they can't burn those fuels. They're dependent on glucose and glutamine. We can replace glucose and glutamine with ketone bodies in the normal cells of our. So we selectively marginalize these tumor cells slowly over time. They slowly start to die, the blood vessels disappear, and the body comes in and dissolves them. So for someone that has never had the time ketone before, ketosis, or ketones, in a simple way, what are ketones? Ketones are water soluble breakdown products of fatty acids. Okay? They're beta -hydroxybutyrate, acetoe acetate. These are small molecules that are water soluble.
20:43They'll deliver, it throws them out like crazy. Kidney a little bit, but mostly liver. So as I told you earlier, when we don't eat, you get anxious mainly because our brains are addicted to glucose. It's like cocaine and nicotine and whatever. You start getting old antsy. Look, I'm gonna eat anything, you know. What's going on? So you then, once the body realizes, you ain't gonna eat anything. We have to start mobilizing out of our fat resources. And the fats go into the bloodstream as triglycerides, which are three fatty acids attached to a glycerol backbone. They go to the liver, the liver chops them up and puts out these little water soluble ketone bodies.
21:26The name ketone body is kind of a weird thing from biochemistry, but they're called ketone bodies. And they can supply the brain with energy, the heart with energy. And not only that, they're a super fuel. It's unbelievable that mitochondria burns these ketones. Okay? But they're, remember I was talking about how energy efficient the mitochondria could become? When they burn ketones, they become even more energy efficient. It's unbelievable. They don't need as much oxygen to generate more energy. That's why my colleagues called, and some of the greats in the biochemistry field called them super, super fuel, because you can get more energy bang for buck burning a ketone body than you can burning a pyruvate coming from glucose, or even a fatty acid.
22:12And the biochemistry for that is interesting. But the bottom line is when you transition away from these fuels to keep, don't forget, we evolved. Our ancestors were always in a state of ketosis. You get into that state by consuming very few carbohydrates and having a lot of energy. And this is the way our ancestors were. So what can we learn from our ancestors about cancer? How prevalent was cancer when we look back at our ancestors? If they were often in a state of ketosis? Yeah, well, it's hard to determine from skeletal records, but I think we can look at modern pop -up, modern man who live according to their traditional ways.
22:54You know, Albert Schweitzer, the great humanitarian physician, went to Africa, and looked at Africans that were living according to the traditional ways. He said, one of the weirdest things that don't have cancer, it was like, what? The cancer was extremely rare in Africans, in a wits living in the areas, British, when they came, you know, in looking at the health conditions of folks that lived in the Arctic Circle, cancer was not there. They had other things, but they didn't have cancer, Aboriginal folks. So it seems as though our living, we can't go back 50 ,000 years ago because we don't have people to examine.
23:34But we have people to examine today, and that was one of the things Schweitzer and several other physicians from Europe would go to Africa. And they would look at these some of these tribes that were traditional, and they would say, whoa, what's going on with these Africans? How come they don't have kids? But when modern diet lifestyle entered into their societies? Cancer out of control. What about other primate cousins? Yeah. There's never been a documented case of breast cancer in a female chimpanzee, and they're 98 % similar to us in gene and protein sequence. You know, what's going on with that?
24:10Monkeys, they don't generally form cancer. They're eating. They're not eating what we eat. Don't forget, we did not evolve to eat pork pies and Dunkin' Donuts, Jelly -filled Donuts and pizzas. We did not. Our ancestors did not eat this. We were killing eating animals. As I said, we ate everything that walked crawled, flew, or swam on this planet, became part of our diet. We did not have donuts in every corner, delicate testons on every corner. We evolved over this period of time, just like our primate ancestors. The animals, chimps and gorillas and things that you see in the zoos are fed their natural diets as if they were living in their habitat, their natural habitat, whether it was in South America, Africa or wherever it was.
24:58We're not throwing in jelly donuts every day and pizza pie into the chimpanzee pen. And as a matter of fact, I even went to the zoo down here in Boston, Franklin Park Zoo, and also to see the Angles Zoo. I said, how come you guys don't give these guys, run down and get a big pizza for these animals? Oh no, it would be animal cruelty. Their systems aren't geared for this. Well, neither are we.
25:25We have an obesity epidemic, we have all these different chronic diseases. Why? We didn't evolve the old crap that we're eating today. So what I've told many people in these podcasts is that our food science and technology and our society's technology has evolved so much faster than our biology. Can you explain to me in simple terms the role that exercise is playing in staving off cancer? Well, exercise lowers blood sugar. And also lowers glutamine. So the two fuels that are driving, now we can't completely remove glutamine by exercise, that's for sure. But my late good friend, George K. Hill published some papers on showing how exercise could actually lower glutamine availability.
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26:08So it's a little bit of a push. But you're also, when you exercise, you're burning and you're not eating a lot of carbs, your mitochondria burning ketones and the oxygenation from all the exercises, keeping those mitochondria super healthy at their highest level of energy efficiency. So exercise, you're building muscle as well, aren't you, sir? Yeah, you build it, well, you can build muscle, but you're certainly getting aerobic exercise to, oxygen is coming in and you're burning ketones, which I already told you is a super fuel. So your body is super healthy. These bodies from the Paleolithic period, these men were jacked.
26:42It was an old B city in these people. They had tremendous energy. They're not dying from the things that are killing us. They're dying from injuries and infections. When you described this slow and gradual shift in the cell, as it moves to this sort of ancient system, it sounded very gradual. So in my head I thought, okay, so does that mean that the cancer is a gradual process that is kind of building up in me, or isn't building up in me based on the lifestyle decisions I'm making and my environmental factors right now? I'm trying to say, does cancer start slowly? Yes, before you find it. Yeah, it is a gradual process, but it can be impacted by several provocative Asians from the microenvironment.
27:30Lack of exercise. Okay. So we're not exercising nearly as much as our Paleolithic ancestors, bar none, right? We have massive amounts of processed carbs in our diets. We have a lot of emotional stress, mental emotional stress that's impacting negatively on our biology. We have lack of sleep, sleep. A lot of us because we have stresses. You have to have, when you put all of these impactful things together in one person, you can put yourself at risk for cancer, all of which will damage and reduce the efficiency of mitochondria. And also the joy of living, having friends and friendships and this kind of thing, reduces stress in a lot of different ways, makes people enjoy getting up and having a nice day rather than being depressed or these kinds of things.
28:25You put all this together and you put yourself in a diet and a lifestyle that puts you at risk for damage to oxidative phosphorylation, and the transition from one form of energy to a fermentation energy. And what I'm trying to understand is that it's a gradual transition. You have to be able to do that. And how long does it take for a colon, a group of cells in a crypt of your colon to transition from one stage to another? You have to be constantly under stress, those cells in that organ. Now why somebody gets colon cancer, another person gets breast cancer, another person gets bladder cancer, and some person gets a brain cancer and all these different kinds of cancers.
29:04Whatever happened, the process was causing a gradual disruption of oxidative phosphorylation, oxidative respiration, and a gradual transition to a fermentation, like in the brain. The neurons, rarely if ever get cancer, but the glial cells that support neurons, they are usually the source of the origin of cancer in the brain for those kinds of cells. And you can look at different cells and some are more at less prone. And why this guy get lung cancer from smoking cigarettes, this guy got bladder cancer from smoking cigarettes. How did it all start? It all started from a population of cells in one of those organs having an acronic, not instant, acronic interruption of oxidative energy, followed by an up -regulation of this fermentation energy.
29:51So really we need to be thinking about all the things that have caused dysfunction in the mitochondria. Absolutely. I want to get a list of the key things that are associated with causing this dysfunction. Okay, carcinogens. Okay, so carcinogens. Yeah, and you know there's so many asbestos, there's all kinds of chemicals in the environment. You hear about this, oh there's a whole list of carcinogens. And they put them on the labels on different chemicals. They say carcinogenic potential and whatever you have. What are the types of things that are carcinogenic that most people don't realize? Oh, well now we're talking about microplastics.
30:22We're talking about... Is that in part what causes breast cancer? Because I always think about deugium with breast cancer and this stuff that we're kind of... Oh, lathering on to our own. Yeah, well the one that was most interesting was the talcum powder one. How does talcum powder would cause ovarian cancer? Okay, it's taken up into the urigenital tract and it forms a foci in a part of the ovarian tissue. What's a foci? A locust, like a collection of material. A foci is an area where say talcum materials would be accumulating. And that leads to an inflammatory area of the body. And our immune system comes in to see what's going on.
31:06Our immune system is a healing machine and they see something that's not normal. Normally they would clean it up but they throw side of kinds and growth factors on there. Leading to dysregulate damage to mitochondria and dysregulated. And then you get this tumor that starts. So if I get a talcum powder, a granule or whatever and it goes into my body, my body then tries to attack it to sort it out. And in doing so it creates inflammation which leads to... Damage to mitochondria in a particular group of cells near that foci. Okay, and this is applicable to it. I guess a lot of different nanoparticles.
31:41Yeah, yeah, and microplastics are this now. They're looking at this. But then we have chemical carcinogens, tetrahydrochloride, there's all kinds of other things that can actually damage arsenics and these kinds of chemicals. You're worth anything that could chronically damage a mitochondria and forcing over time, forcing it to upregulate the fermentation, the energy without oxygen. It's just most things. I'm trying to figure out how to live my life. Yeah, well that's why it was called the oncogenic paradox. But you can avoid that, that's why I'm saying. If you can keep your mitochondria healthy, exercise and reduce consumption of highly processed carbohydrates.
32:22Do I need to be avoiding these microplastics as well? You know, the problem with microplastics, they're very ubiquitous. We're not really sure. We're just now becoming aware of it. Nobody really knew that before. Yeah, look it up. But it could cause small foci in different populations of cells. But you know, it's very hard to really chronically damage mitochondria. Mitochondria, a tough organelle. The problem is we are chronically abusive without realizing what we need to do to keep it healthy. So even if you are exposed to chemical carcinogens, even if you are exposed to all these things, but you're keeping your body as healthy as you possibly can, you could possibly delay or even prevent the damage to the mitochondria, even though you have the, even though you are being exposed to this.
33:06So it's actually in your hands. You can actually reduce risk to floor cancer by knowing what keeps your mitochondria healthy. Vigorous exercise, fasting, water only fasting. You know, it's very hard. But sometimes when we were putting mice on calorie restriction, it was hard to get them to get tumors. Their body was so healthy. This was shown years ago by a couple of scientists and mice using mice that developed a lot of breast cancer. If you put them on a calorie restricted diet, the incidence was way, way down. So you can't say it's very preventable. It's a very preventable disorder. It's just that we're doing everything we possibly can to induce it in our diet lives, though.
33:50A lot of big institutions believe that cancer is a genetic problem.
33:57You believe otherwise. The evidence is striking. I mean, it's not whether you believe it's what the data tells us. Okay. So according to the somatic mutation theory of cancer, mutations in the nucleus lead to dysregulated cell growth. That's the somatic mutation theory. In the mitochondrial metabolic theory, it's a transition from oxidative phosphorylation to a fermentation metabolism inside the cell. The mutations are largely irrelevant. What do you mean by that? When the mitochondria become defective, they throw out ROS, reactive oxygen species that are carcinogenic and mutagenic. What does that mean?
34:39Causing mutations. So a lot of the mutations that we see in the nucleus of the tumor cell, that is the subject of the somatic mutation theory, are downstream effects of the dysfunction of the mitochondria. So the mitochondria is causing a downstream effect, which are mutations, which according to the somatic mutation theory, are the cause of the dysregulated cell growth. Let me tell you why that's absolutely untrue. There's some cancers cells growing out of control have no mutations, and normally not discussed. Well, how can that be? That's a challenge to the theory. If the theory says that all cancers have mutations, and you have some cancers that have no mutations, and they're growing out of control, that should say, well, Bell Ring won.
35:18Then the somatic mutation people, people who think this, said, oh, okay, we have a problem here. Not all mutations are the ones that cause the dysregulated, only som. And we have a name for those som. That's called driver -mute. Okay, now it's a nice term. Because some of those mutations are called passengers. They don't really do anything. But the drivers are the ones that lead to the dysregulated cell growth. So we should be focusing our attention on these driver -mutations. New evidence from the recent scientific literature. Can you believe this? They're taken tissue, normal tissues from patients, different organs, and things like this.
35:52From not patients, from normal people, no cancer. Perfectly like yourself here. We would take tissue from you and say, oh my, crap, look at that. You got driver mutations in your soft August, in your different parts of your body. You got a driver. But you don't have a tumor. What's going on with that? How you explain that these driver mutations are causing dysregulated cell growth, when we have thousands of driver mutations that are there that are not causing dysregulated cell growth? Oh, okay, that's another problem. The biggest devastating information against the somatic mutation theory. This is if you take the nucleus from a tumor cell, cleanly take it out of the tumor cell.
36:27And you have another normal cell here. You take the nucleus out of the normal cell, and you put the tumor cell into that cytoplasm. You get regulated growth, no dysregulated growth. But if I have the normal cell, and have a tumor cell, take the tumor nucleus out of there, and take the normal nucleus, and put it into the tumor cytoplasm, which contains mitochond, defective mitochond, dysregulated cell growth. This has been seen over and over and over again. So just to summarize that, so if you take the tumor nucleus out of the cell, and put it into a normal healthy cell, everything's fine. Everything is fine.
36:59But if you take healthy cell nucleus and put it into a tumor cell, you still have the cell. Disregulated cell growth. Tumor. So which means that it's not the nucleus. Absolutely. It's something else. That's something else. And that's the mitochondria. And I told you, then you have cancer cells with no mutations. And then you have driver mutations in normal cells that never become cancer. You put all those things together. And you have to be a hopeless idealist to think that cancer is a genetic disease. It's a silent assumption in the field that cancer is a genetic... Every textbook of biology, cell biology, and bio -cancer is a genetic disease.
37:34Well, it hasn't people's opinions changed, despite the evidence that you present. It's a very difficult thing. It goes back to when you have one theory replacing another theory. It's called paradigm shifts. And all in history of science, paradigm shifts have been met with great, great resistance. The clearest one was the cappernichian revolution. For eight, 1 ,800 years, astronomers in our earlier astronomers thought the Earth was immovable in the center of the solar system. For 1 ,000, this was the clodiest teleme, Aristotle, and the Bible, and all these earth is immovable, and the sun and the moon and the planets all revolve around the Earth.
38:241 ,800 years. Even cappernicus was working with these mathematical formulations. As Kepp was being constantly confused until he said, what happens if we put the sun in the center of the solar system and consider the Earth as simply another planet that would revolve? All of a sudden things started to make sense. And yeah, Donald Bruno, a theologian, was put to death for suggesting that cappernicus was right. There was a tremendous resistance on the part of the Roman Catholic Church at that time. And this is the same thing that happened when Lewis Pesto said the germs rather than bad air or the cause of disease.
39:06And when Darwin Wallis theory of evolution came, it's not special creation, it's natural selection that can explain this. These were massive paradigm changes in the history of science. And what we're seeing today is the same thing. The mitochondria is the center of the problem with cancer, not the nucleus. The mitochondria, it's a mitochondrial metabolic disease. And once you realize that, we're going to drop these death rates massively in a very number of years for sure. So if we take two paths, and if we realize that the mitochondria is the center of the dysfunction and ultimately disease in the cell, if we go that down that path, what impact you think that'll have on the cancer statistics over the coming years?
39:49It'll drop it massively. Okay. I'm not going to say we'll get rid of cancer completely. But here's the thing, we may never get rid of it, but we can learn to live with it and keep it at bay if we know how to, if we know that it can't survive without these two fuels. And you can do a diet and lifestyle that can restrict the availability of those two fuels and keep your mitochondria as healthy as you possibly can. What if we don't go down that path, what do you think? Then you're going to be right. One out of two people are going to be having cancer. That your statistics are going to be absolutely correct.
40:19Is there anybody that you believe, because when we talk about these subjects, often we think of big farmer and incentives and money and follow the money and you'll figure out why people don't want change? Is any of that sort of conspiratorial thinking correct in your view? I don't know if that's conspiracy. I don't like conspiracy terms. That's absurd. I like what are the facts of what we're looking at. But do you see a resistance from big farmer to entertain this point of view? What do you think? I mean, do you think this is, I mean, you're making a lot of, I'm not you, but, but people in these, and those industries, the hospital industry is making enormous amounts of money.
40:57They're awarding, we get $7 billion a year for cancer research in the, in the, in the National Cancer Institute awarding great many, many, not all, many grants to look at for gene mutations and all this kind of stuff. And we have drugs that are extremely expensive based on a somatic mutation theory of cancer that are basically not dropping the death rate. As I said, we got, while we're talking here, we've got 140 people dead from cancer, 1700 people years getting worse and worse. With, as you said, we're always running for raising money for cancer research. Where's the lot of money going? What are you doing with all that money?
41:33No accountability. And then when you look at the scientific advisory committee of all these societies that you're running for, they won't think published papers on cancer is a genetic disease. It's too hard for the field to accept at this point. It's, it's too traumatic at what I'm saying. It's too disruptive to a massive industry at this time. They will come to gradually adjust to what I'm saying. It's just a matter of time because we cannot continue this trajectory. It's immoral what we're doing to some of these people. I read a stat that said the global incidence of early onset cancer increased by roughly 80 % between 1990 and 2019.
42:15That's in the BMJ oncology. Early onset of cancer is basically patients under the age of 50. And when I think about this, growing up in the UK, whenever there's a fun run, a charity race, a marathon, whatever it might be, cancer research gets the money. And to hear that, you know, there's been so much money invested in cancer research over the last couple of decades, but there's been an increase of 80 % in early onset cancer in the same period. For me, I'm like, this research doesn't appear to be doing it being very effective. Well, as I said, what people don't do is they never ask where the research go.
42:51What kind of research, what are you doing? What is the research? It's the theory that drives the impetus to do research. Now, a lot of great stuff has been done on, you know, keeping people alive that suffer from cancers, right? Because if you think about the probability of dying from a cancer, I'm assuming that has gone down. Yeah, to some extent, it has, you know, we call this two ways of looking. It's called progression free survival and overall survival. These are the terminologies that are used in the clinical world of cancer. And they represent the approval of drugs through the Food and Drug Administration.
43:25If you have a drug that improves progression free survival, progression free means it looks like the drug is working on the tumor. Because, you know, the tumor, you can see it, it gets bigger and bigger and more lethal and more lethal. And if I see it not growing nearly as much, I say, wow, look at the, it's slowing the, what we call traditional progression. Okay, it's called progression free survival. And then you have overall survival. So you have two ways to approve drugs mostly for cancer, right? How does it work on progression free survival and how does it work on overall survival? Well, they stop looking at overall survival.
44:05Now somebody's going to bark and say, well, you know, bottom line is mostly progression free. Which means that the patients, it looks like the tumor is being effectively managed, but they live only a couple of months longer than they would have if they didn't use this drug. So therefore it's approved. And, and, and that as opposed to overall survival, you know, you're only living it to, okay, you live two and a half extra months. The tumor looked like it was managed pretty well, but your overall survival is this much, but you didn't see the tumor growing. We're going to approve that drug. So a lot of the new drugs that we're giving do a really good job, but progression free survival, but they do a horrible job and keeping people alive much longer.
44:44Which ultimately is what you want to do. You want overall survival. Let me give you an example of a vasten bevacism. This, this is an immoral drug that should never be used on people. It was blocked because it caused colon perforations and women with breast cancer. They still use it on brain cancer. And when you, so the, in the tumor, you got a tumor, you can see it with pet imaging and you can, not so much pet MRI and cat scan. And you can see it there. And it's looking there. Okay. You can see it. Now you give the patient a vasten, and which is this anti angiogenic drug. It's supposed to stop the abnormal blood vessels, right?
45:23They think that the angiogenesis blood vessels is, is driving the dysregulated growth. It's the fermentation that's driving the dysregulated growth, by the way. So all of a sudden you give the tumor kind of disappears. It doesn't look like it. Well, patient gets all excited. The physician looks and says, look at that. Look at that. Looks like you're doing well. What it does, the, what the drug does is it causes the tumors to permeate your entire brain, just spreading it through your whole brain. You don't live any longer. But you had this progression free. Look at the tumor. So the patient gets excited because it looks like the tumors disappearing with this very expensive drug.
46:02But what it does is it almost guarantees that that patient will not survive because you spread the tumors cells through the whole brain. So this is why I call it an immoral kind of a thing. But chemotherapy and sort of these radiation therapies, they have proven to keep people alive who otherwise would have died. In some cases, they, it can. And that's another thing we have to look at. Do we have, and I work heavily in brain tumors and glioblastomas and things like that. When you irradiate somebody's brain, who has one of these tumors, you free up massive amounts of glucose and glutamine in the micro environment.
46:34And if you look at the survival, when we did survival, looked at survival curves for glioblasts throughout the world, you can't even design experiments so consistent how fast people will die. It's like all the different hospitals have the same survival, same survival. What are you doing? Well, we do chemo, we do surgical debulking, Temozolamide, and we give steroids which raise blood sugar and we irradiate. We irradiate. We irradiate. Everybody's dead. So not everybody, but you know, five years survival is very, very low. Ten years survival is almost zero. But if you go, if you got a breast cancer, or if you go, this is brain cancer, I'm talking about this is freeing up now.
47:13Yes, if you have a circumscribed tumor and it's not anywhere else, you can come in with a radiation or surgical procedure and cure, essentially cure that patient. But if you have any level of spread or anything like this, that person now, and also if you're taking a toxic poison into your body like red devil, doxarubusin, they call it red devil, your p turns red, everything turns red. What is that? Is that chemotherapy? Yes, it's a chemotherapy to kill a small group of cells or maybe a little bit of a spread. But your hair falls out, your body gets brutalized by this. And then if you survive the cancer, and many people do, we have millions and millions of cancer survivors on this planet.
47:54But many, many folks in that group suffer from the adverse effects of being poisoned or irradiated or surgically mutilated. I mean, they have to change their hold. And oftentimes the cancer comes back or they die from cardiovascular disease or they die from secondary adverse effects of being brutalized. With medieval, I call it medieval approaches to this. Are you kidding me? What they're doing to cancer patients? So when we do metabolic therapy, we shrink the tumor down for sure. Then the surgeon can come in and he sees it smaller, fewer blood vessels because of the metabolic therapy and we can take out a greater amount of this.
48:33And then we transition back to prevent this tumor from recurring. Metabolic therapy can be used to not only prevent the cancer, but can also be used to treat the cancer. Now they only tell you, most hospitals, suppose people say, well, I really want to do things to prevent cancer. Can I do standard of care before I have a tumor? What do you mean? You want to go into a major cancer clinic and have toxic, toxic rubison and radiation to your body just in the event that you might get a cancer? This is absurd. But yet when you have cancer, that's what they do to you, right? But with metabolic therapy, you can use it as both a prevention and a treatment.
49:08It's just that with a treatment, we bring in some more drugs to target the glutamine. We don't do that on the prevention side. On the, I was just looking at some stats as you were speaking around the five year survival rates of a variety of different cancers over time. And it does appear that survival rates of these cancers from breast cancer, prostate cancer, lung cancer, telekimius, various melanomas has improved since the 1970s. So the 1970s to the 1990s to 2010s, there's been an improvement in the survival rate, which I guess is a credit to the research that's been done. What you're saying is that the treatments we have still today are horrific.
49:48Yeah, and the, and the survival's are not that much greater. It's not like you're getting massively longer survivals. Yeah, I mean, I have to, I have to preface that these stats might not be right because this is AI we're dealing with here. Yeah, but there's a 5 % for example with breast cancer between the 1990s and 2010. There's just a 5 % difference in overall survival. Okay, so your survival, your overall survival is 2 .5 to 3 months greater. I don't actually have those stats in the video. No, but that's that's the evidence the papers that we're looking at. So, so how do we prevent? Prevent this then.
50:21I'm 32 years old now. So I want to make sure that I live my life in such a way that I limit my chance of cancer. One of the things I always reflect on is the fact that many of the people that I know that have got cancer, breast cancer or other forms of cancer, appear to be remarkably healthy. Yeah, always at the beginning. They're not always, but many times the person comes and says, she's just diagnosed with cancer. I didn't know I had it. I didn't feel bad. And they're all the sudden you get treated and they look like death warned over. But I'm saying like how can healthy people be getting cancer if there's this sort of central?
50:52Well, because you, as I said, are the, the, the, and we're seeing this. I'm seeing it in my own. I'm getting more and more emails from young people in their 30s, late 20s, 30s, early 40s, like with colon cancer, breast cancer and all these kinds of things. But look at our diet and lifestyle situation today. Those, those things that I'm talking about, lack of exercise, a lot of stress, poor sleep, bad food, all of this kind of stuff impacting parts of our bodies. So what do we do about it there? Know about it. And then, and then what do we do? So I know that's that's personal choice. I'm not here to take pieces and jelly donuts off the market for sure or a breakfast here.
51:29I love that stuff too. But the question is I don't eat it every day. And I know if I do, it'll kill me.
51:38So, so yeah, skipping meals, water only fat occasionally. There's a lot of things you can do to keep your mitochondria healthy. Okay, so tell me what those things are. I just exercise. You look like you're a pretty healthy guy. Yeah, I go to the gym. You don't look morbidly obese to me. Not, not, yeah. Well, that's important because you don't ever want it yet. We've been America too long so much. Yeah, well, and listen, it's not just the United States. We were kind of like the first ones to plow that field. But it's starting to spread everywhere. I think in China, they have the most 200 million obese people in China now.
52:07So, should I be on the keto diet then? Here's what we did. Okay. We developed a glucose ketone index calculator at Boston College. All right, my students and I, because we were trying to work with cancer patients, blood sugar and ketones independently of each other. We had a ketone meter and we had a blood glucose meter. So we were monitoring ketones by itself and glucose by itself. And we worked with a very nice woman from America who lived in East France who since passed away from a brainstem tumor. It was very, very difficult. We kept her alive very long, but eventually we didn't know what we know now.
52:46But she got into an argument for a handicap parking spot with her neighbor upstairs and her blood sugar went through the roof. She ran upstairs and she took her blood sugar. And she says, oh my god, the tumor's going to grow. I said, what's your ketones? And she says, oh, it's still 2 1 ,5 milli -mole. Well, that's still pretty high. Usually it's very, very low. It's very, very high. So my students and I, we said, you know, this is too traumatic to try to measure these two independently. Why don't we make a singular number divide the glucose in a milli -mole or in the blood by the ketone and milli -mole or in the blood.
53:17But now you get this number that's much more stable. And it allows the cancer patient to know that if I keep the zone at 2 .0 and below, my tumor cells aren't going to be able to grow very fast. I did this for the brain cancer, right? Now it's being used for all cancers. And now it's being used for guys like yourself who just want to stay healthy. Because what it is essentially is a quantitative determination of you're in the paleolithic zone or not. Oh, so if I'm at 2 .0, like my friend Dominic Diagostino, he's always down on these zones. He's a paleolithic man living in modern society. What's a paleolithic man?
53:52That's how our ancestors were during the paleolithic period. Okay, so he's got the right balance of glucose and ketones. It's like we did when we were hunting mammoths and buffaloes and these kinds of things. When we were hunter -gatherers in the thousands of years of our existence as a species, tens of thousands of years, he is in that zone. Is he in keto? Yeah, well that's what the low GKI is. That means you're at a level of keto. Yes, he doesn't eat a lot of carbohydrates in his diet. He's leafy vegetables and a lot of meat and this kind of thing. Sparingly on fruits, like grape fruits we learn from the epilepsy field, grape fruits provide a tremendous amount of vitamin C and do not spike glucose.
54:33That's very interesting. So you can have certain fruits that can keep you in this metabolic zone of pale. I call it the paleolithic zone, which is the way we evolve, but there was no cancer in our existence. When people hear that, they might start jumping on the paleo diet. I don't even know what the pain is. Not a paleo diet. It's a diet that are low in carbohydrates, okay? I can. Mediterranean diets. People say to me, you told me, what should I eat? Should I eat this? Normally, you would eat foods that have very low glycemic index, which means the speed with which glucose is released like a banana.
55:04Very high in glycemic index. You eat a banana, you have blood sugar, immediately spikes. Many fruits are like that. But you want foods that keep a low -steady GKI. Now, I built that calculator for brain cancer patients initially. Then we realized it's powerful for all cancers. We put the cancer patient in the low glucose ketone index. We get them down in there. Then we come in with the glutamine targeting drugs to kind of polish off these tumors or put them in even a more dormant state. But now, I'll find out all these young kids. Like yourself, all these 30, 20 -year -olds, what's the GKI? I mean, around the weightlifting and they're looking at their G...
55:44They don't have cancer. They're just excited to see if they can get into this paleolithic zone by themselves. And that, yes, that will prevent cancer. Because you can't get cancer if your mitochondria healthy. If you're in a paleolithic zone where our ancestors, there's rarely if ever got cancer, then you're back in this... Oh, you mean to tell me I can't eat this and I can't eat that? What does it do to your GKI? Oh, it may say go up, well, don't eat that. So you did a study on dogs. I dove a tumor. Can you tell me about that study? Well, it was a woman came to me and this is... What I say, you don't have to have a PhD in biochemistry to understand what some of the things...
56:20This woman had no degree whatsoever. She just heard about what we did to these mice and she did the same thing to her dog. It was a pit bull and at age seven years old it had big masts cell tumor on its lip. So she listened to my YouTube video over and over. She said to me, I just kept listening. She says, I got some raw chicken. She says dogs wolves evolved to eat chickens. So she got some chicken chopped up the chicken. She cut the calories of... She found some dog food calculator to how much calories the dog was getting. She cut the calories, the dog looks lost only 5 % of its body weight. She got a pelvic fish oil, raw eggs, and cut all the calories to everything was all natural for this dog.
57:07And all of a sudden we have the pictures. You can see them in the... If you saw the picture, big tumor on its lip, the veterinarian said this dog is going to survive. You have to give him chemo and radiation and surgery and all this kind of stuff. And it's going to cost a lot of money. The dog's going to have diarrhea. It's going to be... Well, she didn't want any part of that. So she said, well, let's just try this metabolic thing. And she's kept all the records in the pictures and what she did and how much she gave the dog and all this. I was able to get all that information from her, put my friend Lauren...
57:38Lauren Nations, who was a veterinarian on the paper because I said, what biology guy at Boston College is telling you how to manage cancer in a dog. We got to have some veterinarian on here to validate to make sure he's there. And he looked at the pictures and we looked at all the things that disappeared. So what happened was the dog eventually died of heart disease at 15 and a half years of age. So essentially that's the only... When people say, well, metabolic therapy, cure cancer, I say metabolic therapy is never considered a cure for cancer. It's an effective non -toxic management for cancer.
58:12But in the case of that dog, it appeared to work. It's a cure for the dog. But that's the only one I'll say. Oh, he's going to say, cure, can't not. That dog happened to get... He died from old age from a heart attack. And we did it with a brain tumor guy, Pablo Kelly, who just passed away, unfortunately, from a surgical... He had a major cerebral hemorrhage after his surgery from Devon England. You know Devon England? That's what I'm from. Are you from Devon? Yeah. Oh, wow. Well, Pablo was there. He just passed away, fortunately. We've talked on to him the day before he passed away. Pablo Kelly.
58:43So he was from Devon England, had a glioblastoma, which is the worst of the worst. He's all over your newspapers there in Devon. He was always sending me articles from England. Man rejects standard of care. So he had this glioblastoma, and they took the tissue out. Which is brain cancer. Yeah, brain, the worst of the brain cancers. They took the tumor out, and they said, Oh, it's inoperable. Inoperable. But if you do radiation and chemo, you might live nine, maybe 12 months at the most. Well, Pablo came from a family of like, we don't dabble in this kind of medicine. We're more holistic kind of people.
59:25So he emailed me. This was in 2014, and said, I want to try this metabolic thing. So he rejected chemo and radiation, and they said it wasn't surgically capable of being completely removed anyway. So he did this. I gave him the information that I give to everybody. And this was way back before we knew a lot of what we now know. And I said, this poor guy, he says, he doesn't want it. And they said, you're going to be dead. They brow beat him. They try to force them to put the radiation mask on. They hacked his beard off. All this kind of stuff. And he just jumped up, he said, I can't do this stuff.
1:00:03So he didn't take any steroids. He didn't take any radiation. He didn't take any chemo. He just did the metabolic therapy. And he's on English television or things with all of his paleo diet, which actually a very low carbohydrate diet. He had the avocado, stereo, the fish oil area, this different stuff. Two and a three years go by. He emails me, I said, Jesus, Pablo, what you would have been dead. Still alive, what's going on with that? So he calls me up and he says, you know, I went in for a CAT scan. The doctors are like still surprised that he's alive. And they said, this tumor is still there and it's growing.
1:00:41And they think they can cut it out now. So he was three years on just metabolic approach. He didn't take any glutamine inhibitors, which was really remarkable. So anyway, he asked me, and I have physician friends that are radiologists that can look at it. And they measured that when it was first diagnosed in 2014. And then we saw it did become a little bigger. So now the surgeon said, I think I can get it. It looks more more susceptible. Here it was inoperable. Now it becomes resectable. So he took it out. And Pablo recovered really well. And the surgeon says, I think I got it all. Wow. So, and Pablo is measuring his glucose ketone index with our keto amount of it.
1:01:24So I had every day, sometimes two and three, five years at that on Pablo Kelly. Can you believe this? So anyway, Pablo thinks he's cured because the surgeon, all of the sudden he goes back to his kind of week, week ways. And you can see that his GKI goes up. And all of a sudden the tumor starts to show up again. Pushed the fear of God back into him. Goes back on a more restrict condition. Another three years goes by. And this time the tumor is growing slowly, very slowly. Again, glial blastoma is killing you very quickly. With standard of care, you can barely get out of at his age. If you can get two years, you're doing, you're doing really good.
1:02:02So anyway, now he's three and he's got six years out. And he says, you know, it's still back, you know, I got to go in. So at first, so this is second to bulk. First the bulkier goes off gets back on. Another second, the bulkier. So another three years goes by. He has a third the bulkier. Can you believe this? A third the bulkier. The bulkier is the cutting the tumor out. It's the removal, a surgical removal of this tumor. But he's never had radiation or chemo or any of the kinds of stamp, what we call standards of care. So for, and now he has, I talked to him a couple of weeks ago. And he was doing, he was doing really, really good.
1:02:39He had the third removal and we were laughing with myself and Dr. Durya and my associates. He says, yeah, can you imagine? I've had now three operations on a previously inoperable tumor.
1:02:56So we were saying, wow, they got that one wrong. Didn't they follow up? And they kept wanting to irradiate them and do all this stuff. And he said, no, no, I'm going to keep doing this. And so we were speaking to him. And he's now 10 years. The tumor was diagnosed in August 2014. And he passed away August 2024. From, they tried to go in and get the last bit of tumor out of his brain. He came out a week by the time we talked to him. Thumbs up, smiling, talking like crazy, six hours later, cerebral hemorrhage. And he dies. So he didn't die from the cancer. He died from a surgical problem with the surgery.
1:03:35So he was, you know, you talk about long term survivors. You rarely survive two years with the glioblastoma, the fact that he was out 10 years. And if he hadn't had that last bit of surgery, the guy would have still been alive. Because he was talking like you and I are talking. This is a guy who has a terminal. So I said to Pablo, I said, you could outlive me. I said, we're all terminal to some extent, right? Whenever all of us aren't going to live to it. I said, he was a young guy. He was only 22 or 23 when he was diagnosed. He was in his 30s now when he passed away 10 years. So he's 33, 34 years old.
1:04:08And I said, you know, I could be dead before you. And we were laughing. And we had a good time. And the next thing I got an email from his wife, he said, Pablo is on. He was on. He was brain dead and something. I said, what the hell happened? What happened to this poor guy? And it wasn't the cancer. So who now? I don't know what how long you would have lived, how many more things. But what I'm saying, oh, he's an anecdote. Listen, if I had a drug that did what metabolic therapy did, and I could get more people like Pablo, are you kidding me? They'd be running all over the world. And when you say metabolic therapy, you mean the combination of the calorie restrictive?
1:04:45Yeah. ketogenic approach. Avoiding. Well, first of all, you're avoiding things that are going to kill you. The radiation is going to kill you for many people. Not all people. Okay, everybody say, well, listen, you can look at the, go have people look at the data themselves for crying out. And you can see how long you're going to live. He didn't do what they, what they grab everybody in. What did he do specifically? He didn't take radiation or chemo. Yeah. And he brought his glucose ketone index down to the 2 .0 zone and kept it, kept it low. And he took some supplements and a few things here and there.
1:05:16But he wasn't really targeting the glutamine like we thought it, we thought we, we thought we, we found now certain parasite medications will be effective in targeting glutamine. So we're doing all non -toxic strategies to manage cancer. You don't have to be brutalized by the system. If you know what to do and how to do it, the problem, the problem is most of the poor oncologists never heard of what I'm talking. The stuff I'm telling you right now, they never heard of it. The risk is someone gets cancer that's listening to this or someone has cancer that's listening to this. I mean statistically there's a lot of people listening to this, I have cancer right now.
1:05:45And they're speaking to their doctor. And their doctor is saying chemotherapy, radiation therapy, et cetera, et cetera. And glucose has nothing to do with tumor, eat whatever you want. Yeah. And so what do you say to those people who are, who they've just got a diagnosis? And their doctors are saying, right, listen, this is pretty bad severe. We're going to suggest that you take chemotherapy. Yeah. You're not telling them not to take chemotherapy, are you? I'm not telling them that. And what we found, what we found is that when you are in nutritional ketosis with a glucose ketone index of 2 .0 or below, my colleagues that we work with in Istanbul, Turkey, we're able to show that chemotherapies at much lower dosages can be even more therapeutically powerful when you're in nutritional ketosis.
1:06:27So you don't have to get rid of a lot of these different procedures that we have today. I'm just saying radiation for brain cancer. I'm not saying radiation for a long or some of the other cancers. Because if you can, if you can shrink those tumors down and make them very weak and vulnerable, a surgical procedure or radiation procedure, even low dose chemo could come in. And even immunotherapy, if you, if you took a big tumor and shrunk it down to a small, small nub and it's resistant to a lot of the things, they all have to share something in common for them to survive this path. That might be an immunotherapy, but you could come in because they're going to target whatever all of them have together and you could possibly get rid of it that way.
1:07:06I'm thinking of a friend of mine that has been diagnosed with brain cancer, brain tumor. And this is one of the most, you know, it's a woman in her 40s or 50s, trying to keep her anonymous as possible, who is just the most fit athletic person that either I know eats amazingly well, is literally known for exercise. And I'd go, how? How is it possible that someone who I would probably say is fitter than I am if you looked at this sort of metabolic health has got a severe brain tumor? Well, they can stay healthy for, and I'm not saying everybody who has, as it depends on what kind of a tumor it is as well, is it a glioblastoma or oligodendroglyoma, you know, peanut, a lot of different kinds of tumors.
1:07:52Well, I know that it's not growing necessarily, but it's big and it's in the brain and they're going to remove it for a surgical operation. Well, if they can, what we always suggest for the brain cancer, if you do metabolic therapy up front, and I've had surgeons tell me this, you can shrink it down, because one of the, it's angry, it's an angry thing, right? And you can see some slight invasion. If you can shrink that down so that it's more circumscribed, now the surgeon can look at it and go, oh my god, we know many, many scientific publications. The more you can debulk, that's called the removal of the tumor, debulking.
1:08:29The longer the patient will survive, the evidence is massive to support that. But, you know, with a lot of these brain tumors, you don't get it all. And there's always some little piece that remains, and when you irradiate, you explode the ability to sell us the ferment energy, and it's very hard to kill them. But if you can get the majority of it out, and then transition the patient back into a metabolic state, keeping the pressure on those tumor cells, you can remain healthy, like Pablo, I mean these guys can... And when you found in mice, is that when ketogenic diet was combined with hyperbaric oxygen therapy, the average survival time was increased by roughly 80%.
1:09:03Yeah, even more sometimes now. But okay, so why do we hyperbibaric oxygen? Right? That's the question. What's going on with hyperbaric oxygen? Why is this like a good thing? It works best when the patient and the mouse is in nutritional ketosis. Okay, so look, we have a tumor. We irradiate that tumor. How does the radiation kill the tumor cells? If its oxygen blows up and it causes a reactive ROS, and it's like a stepping on a landmine, it blows the tumor up, right? So, cancer cells protect themselves, even though they make a lot of rust, they're this close to death anyway. But they have a very powerful antioxidant system, and interestingly enough, that besides causing the dysregulated growth, the glucose and the glutamine also protect them to some extent from the rust that they're making.
1:09:57Can you believe this? The roasts. ROS, ROS, reactive oxygen species that are carcinogenic and mutagenic. So, they destroy our proteins, lipids, and nucleic acids. They're disruptive molecules. So, radiation will cause a ROS in the microenvironment, ROS that will blow up and kill cells, normal end and tumor cells. But if you want to selectively kill tumor cells, with ROS, not to cause your hair to fall out, your gums to bleed, and all this crazy stuff, you take the patient, you put him in nutritional ketosis, and you say he's got a low GKI, then you go into hyperbaric oxygen, which dissolves oxygen directly into your blood now.
1:10:40It's better than just breathing 100 % oxygen, because you can actually dissolve oxygen in the bloodstream. Then you're taking away the two fuels that protect the tumor, and you're giving it internal ROS, which kills the tumor internally, only to the tumor cell, not to your surrounding tissues. So, you're killing selectively killing tumor cells without collateral damage to the rest of your body, as a matter of fact, the rest of your cells are getting super healthy, because they're burning ketones in pure oxygen. How do we measure for... Can you believe this? I can't even believe I'm saying this stuff myself.
1:11:13You really got to know the biochemistry, and you don't have to know the physiology of your own body, and you have to understand evolutionary biology. Most people just aren't that intelligent, including me. It's not intelligence. Most people kind of want things sort of simple principles that they can live by and implement. And also quick and easy. Yeah, of course. They don't want to do what I'm talking about it, because it might be... Let me tell you one thing and remember it. If you do metabolic therapy success rides heavily on your shoulders. You're not sitting there like some porn with mannequin, some guys poison and are radiating it.
1:11:47To make metabolic therapy work, you are the one doing the GKI. You're the one... It's your soul. It's your responsible for your existence on this planet. You're going to put your precious soul in the hands of someone who has a less of a knowledge about the problem than you might. As an entrepreneur, I'm always looking for ways to connect and to create. And that's why I decided to launch the conversation cards. I turned to Shopify, who also sponsored this podcast, and Shopify made it so easy to set up an online store and reach all of you, no matter where you are in the world. I remember the challenges we faced when we first launched the Diroverseo conversation cards, managing inventory and throwing a seamless checkout process and reaching our audience.
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1:13:40Over 41 ,000 businesses have chosen to future proof their business with NetSuite. So if you'd like to learn how it can help your business, head to netsuite .com slash Bartlett and free download the CFO's guide to AI and machine learning. That's netsuite .com slash Bartlett. Could you be predisposed genetically to accounts? Yeah, that's where those germline mutations, but you can manage that. Because people think my grandmother had breast cancer, my mother had breast cancer. They live in a common environment too. It's not like you're like in order to prove that. You and all the siblings would have to be raised in a different environment, different countries, different lifestyles.
1:14:16And then see if you all got cancer at the same time under all these different conditions, that's definitely genetic. That's like Huntington's disease, Tasex disease, or these kinds of things, where they'll manifest regardless of the environment. So you're saying to me that I should, as a 32 year old man, that's cancer -free, God willing, I think I've touched with, I should calorie restrict myself to keep my mitochondria healthy. And my metabolism healthy now, I should be in a sort of a health restricted state. Yeah, I say it's good to visit the state. Our paleolithic ancestors had no choice. There wasn't a donut shop on every corner.
1:14:52There wasn't pizzas. There weren't the kinds of highly processed carbohydrates, foods available to them. So should I be fasting? Should I be doing keto? I don't want to tell you what you should or should not do. I'm not a physician here. I'm a scientist. I study what causes these things, and I study how to manage them. You have to read what I'm saying, and you have to come to your own decisions about how you want to conduct your life. What is your view? I've given you information. What's your view on fasting? Fasting is a powerful way to get your body into nutritional ketosis, but it ain't easy.
1:15:23Try doing it. Try you try doing it. See how easy it ain't easy, right? But that's why we developed this procedure where if you go rather than go in cold turkey, and say, today I'm going to have a big, I'm going to eat as much as I can, and then tomorrow. Okay, you can go to my eye. It's the second, third days when you start to really know what that was going on. Believe me, I've tried it. It ain't easy. That's why we developed a zero carb diet for 14 days, 10 to 14 days, just zero. You eat meat, fish, chicken, whatever you want, but just don't eat any bread pasta, this kind of thing. On keto, how do we get into that sort of ketosis state that people often talk about?
1:16:02Measure your glucose ketone index. How do I do that? With the keto mojo meter, you can buy it from Amazon. Okay. Okay, you can buy. Now, don't forget they get a free leabron meter now for the blood. They're working on ketone blood meters, but it's not there yet. Right now, the keto mojo, or some other keto meters, where you can take a prick, your finger like a diabetic, you take a glucose strip and you put it on the blood and you put it into the machine, it tells you what your glucose is. Squeeze your finger a little bit more, take the ketone strip, touch it to the blood, put it in the meter, it gives you the ketone value, push the button GKI comes right up.
1:16:34Okay. Okay, very simple. Everybody can buy it from Amazon, get the meter by the consumables, and then they can test it. This is what Pablo, this is what all the cancer patients, the ones who really want to get into metabolic ketosis. I think I've tried keto before, and I say think because I didn't measure my keto level. Yeah. So I was a shimmy idea. Yeah, no, it's really people say, well, I haven't eaten, you know, I'm in keto. How do you know? Well, I blew into this thing and the bulb came out, I peed on a strip, it looked like it was ketosis. They are indirect measures. The most accurate is the blood measure.
1:17:06It's hard to stay in that state for most people, right? This is one of the things I can do. Because the temptations in our society are so strong. Yeah. I mean, paleolithic man had no choice. Do you think he, that was his state, that's all he knew for thousands and thousands, tens of thousands, hundreds of thousands of years? That's all he knew. He didn't say, I'll make go down to get a big jelly filled out at the end of the river there. No, there's none of that. He had to live in that state. Now we have so many temptations, all the things that we are biologically clear for. When you see obesity, that's evolution in action.
1:17:40They are the descendants of our long ancestors that could hold on to energy so efficiently. We were in an energy starve species for the majority of our existence on the planet. So anything we ate would be very little waste. We never peed out glucose. Glucose is converted to fat and we store energy as fat. So those guys are energy, efficient human beings. Now all of a sudden we find ourselves with everything. That's evolution in action, man. We're just, we're just, you're allowing to see how we can store energy so efficiently. Because our ancestors lived through such environmental forcing. We had famines.
1:18:21We had long tracks. Our body could store energy so efficiently. Because it wasn't, we had to store what little we could get from the environment. And now we've got 300 million Americans in this food environment where, when they walk out their front door, they see the Dunkin' Donut. They can line bad in order of Dunkin' Donuts to have their own 10 minutes. You don't even have to unass the car. They can't do through the window. Yeah, so no energy, no energy expenditure energy and... So, so, giving them this information might be fairly futile because the temptation... Well, yeah, well, that's, I'm not here to tell people again.
1:18:52I'm not here to tell people what they should or should not do. I'm just here to explain like, why do we have all these, not mystery. It's all biological evolution. You understand biological evolution. Almost everything that I'm talking about makes perfect sense. And unfortunately, that's not part of our scientific literacy anymore. So, we need what, discipline? Discipline is important. Discipline is important. You know, every major religion had had a point of fasting. To be whether your Islamic Judaism or whatever, Catholicism, Hinduism, whatever, I don't know, whatever. They always had some sort of fasting.
1:19:31Why, why you do fasting? Because you want to purify your body. You want to become closer to God. You want to, you want to, you want to feel in control. And that's always point. And if you do it with prayer, it's even better. So, there was a reason for doing all that. People realized the ancients knew this kind of thing. But we don't do that anymore. We don't go 40 days without food like Jesus did in the deserts. But a human being, you can absolutely do that. I know because I can look at your weight. I can look at your size. And I can pretty much tell you how long you can go before you died. And how do I know that?
1:20:08Because George K. Hill, a good friend, late George K. ran the Jaisland Diabetes Center. And he evaluated people that would just go water only fasting until death. And some of those constant, you know, mays, prison camps and things. So, he was able to know how much you could, how long you could go. Now, what about Angus Barberi went 377 days without food? George K. Hill would fast some of these obese people for 250, 300 days. What happens inside their body with that? They burning fat. So, what happens is you burn fat. Okay, liver stores a lot of bone store the minerals that you can get minerals from your bones.
1:20:50You can get a lot of fat storage vitamins are stored in fat, a lot of vitamin D. Outside of the weight loss, what's going on? And, you know, we said, really just people used to fast to get closer to God. Yeah. Which seems to me to point to some sort of cognitive. Yes. And you ask from burning ketones. When you burn ketones, I said in the brain, when your brain starts shifting to ketones, your energy, the bang for the buck for each calorie that comes in from a ketone body, increases the efficiency of oxidative fast for allation. So, you're more focused? Massively. And, you know, this is why our ancestors were the way that if you are dependent on killing some animal for your survival, and you are out on the hunt, you are focused.
1:21:36Because if you're not focused, you're going to starve to death. So, every organ, since organ in our body is super jacked when you're in these ketotic states. So, and these guys walking around with headphones, listen to that, you know, all this. I mean, this is like the priving ourselves of the natural ways of our ancestry. Don't forget, we're not just you and I are not just here over the last, you know, 100, 300, 400 years. We are the descendants of members that are same as us, you know, hundreds of thousands of years ago. They just didn't have the technology that we have today. But if you could put a paleolithic man from say 500 ,000 years ago, and you gave him a bunch of donuts and told, he would die, he went to heaven.
1:22:18You mean to tell me, I don't have to go out and kill the elk anymore, they're going to hand me the food right through the window. Of course he's going to do it. You go in the cave and you throw a bunch of jelly filled donuts into a bunch of cavemen who've been chewing on the half eaten rat or something. You think they're not going to eat those jelly donuts? They have some chimpanzees live with the family down in Florida there, some YouTube thing. The chimps that they're eating the food with the family. And then they give jelly sandwiches to the chimps to bang another table. You think they were going to go crazy.
1:22:48Chimpanzees love on the jelly sandwiches. Do you have kids? Yes. What advice would you give to your children if they're listening to this now about how to prevent their chance of getting sick through cancer? Well, they'd probably say, well, dad, how come you don't do a lot of the things? First of all, I'm not telling, I told you, I don't tell anybody what to do or how they do it. I'm just telling you the science behind why things work. Yeah, my children, my two sons and my, they're all very, very successful. And they said, if we ever got cancer, we would be doing the metabolic therapy if we were to ever get cancer.
1:23:26And I said, just keep exercise and do what you can do. The best you can in our environment. I mean, don't get me wrong. I mean, I'm eating a jelly donut. I'm drinking beer. I'm drinking whiskey. Why? Because I like it. But I'm not going to be doing it all the time. You know, it's just, it's just, I'm not going to be saying, I'm going to eat pizza sure. But I'm not going to be not doing it. I do intermittent fasting. I don't eat for 18, 20 hours at a time. I do a lot of exercise over at the university, the gym and the facilities that we have. But I understand it. And then if I were to get cancer, I would have to bite the bullet and do what I'm, would do what I know works as much as it wouldn't be pleasurable.
1:24:07But it would be certainly a better alternative than being irradiated and poisoned. I'm telling you that. If that has brought your conviction to the point that you're so convinced that the real issue is this sort of metabolic dysfunction. Why aren't you optimizing your life to be sort of metabolically perfect? Well, because I live in the same society you do. Yeah. Okay. And fortunately, yes, our technology has improved significantly. You know, I'm not a monk. I'm not going to be in some monastery, you know, chanting something. I am a member of this society just as you are. And I enjoy the things that we have to offer us to make our lives a little bit more pleasurable.
1:24:48There's nothing like sitting down over a nice meal and having a discussion with some wine and enjoying it. Enjoy the moment. But not to be locked into that kind of diet and lifestyle all the time. Put you at risk. There's an election going on in the United States at the moment. Trump versus Kamala Harris. If you are on the election and you became president of the United States and you have to introduce some regulations or some laws around food and all of these kinds of things. What would you do? Well, I think, you know, you're talking about a food industry. You're talking about a multi -dimensional economy.
1:25:27I would not, again, you don't want government to tell you what you should do. You should make the choices. But you have to recognize, are there are there choices? And what are these choices? Right now, we're not, and we're not seeing or understanding how things harm people. If we have an obesity epidemic and that would put you at risk for all these horrific chronic diseases, why do they not know that? We introduced some regulation in the UK regarding smoking. So you can't smoke inside anymore. But do you see your second -hand smoke can impact negatively the person sitting next to you? This obese person's personal choice to be obese is not going to make you obese or sick.
1:26:11So this is a different kind of a situation. That has to come from internal to the person. And they have to be concerned with their own health. We're not drugs though. Like cocaine is not legal. So why can't they intervene to say you can't have Dunkin Donuts? Because they're both, you know, going to hold me into the juice. I think you'd get a revolution if you can't eat a Dunkin Donut. You're not going to get a revolution if you can't have a... You try to go down here in Brooklyn and take away all these donuts from people. You know, you're going to see they're going to go. You know, it's like, it's personal choices.
1:26:45I like Dunkin Donut. I mean, I like the coffee especially. But you can go to a donut shop and get some of these crawlers and jelly fills. And you can't get these. You can't get these blueberry muffins. It's a tremble when you eat some of this stuff. You know, it's... And I'm not going to take that away from me. But if I want one, I'm not going to be... Oh, every day I got to eat. No, I just don't eat it. On the weekend, I might get one. And even sometimes two or three weeks months go by before I'll get one. You know, but when you get it, man, you enjoy it. You really love it. Are you hopeful? I am very hopeful.
1:27:19Because when your science comes, you can't suppress the truth. It's going to come out. The evidence, the scientific evidence is there. I'm documenting this scientific... And it's based on the shoulders of Otto Warburg. Are you kidding me? I mean, this was a giant in the field of biochemistry. It's not like I made this stuff up. I'm just extending what he has done to a new dimension and putting it into a practical application which he had never done. So it's just an extension of the knowledge base over this time. Why'd you cast so much? Why do I care so much? You know, I'm not in it for the money.
1:27:54You know what I'm in it for? I want to see the scientific principles substantiated. If you know that you can keep these people alive at a higher quality of life based on the knowledge of the science that's doing that, that's gratification, man. It's gratification to know that these... Because you were right on understanding the mechanism of the problem. And if you say, you know, if we do it the way we're writing a big treatment protocol as we speak, it's under review, a really comprehensive treatment protocol. And we institute that in the clinic and for glioblastoma patients and these advanced cancers, they're not living a few extra months.
1:28:33They're living several years longer. Why? Because you knew the science. What's wrong with that? That's gratification. You don't have to make a billion dollars on that. What you have to know is that all those folks are living longer because you understood the science that was put into apropractical application. What's wrong? Our research is supported by philanthropy and private foundations. That money allows me to do these experiments, to test what I'm testing, on pre -clinical models, and then we translate it back into the clinic directly. And we see, like Pablo Kelly, he should have been done years and years ago.
1:29:09He lived all those years extra. He's had a wife and he's got kids. He didn't have to have his sperm frozen. He didn't have to have any of that stuff done. What's wrong with that? I'm seeing people that are should have been dead a long time ago and they're still alive and they're saying, I'm doing fine. I get calls from people. Geez, I thought that guy would have been a goner. He's still alive. He's doing well. I said that keeps me going because it tells me that we're on the right path. This is a solvable problem. This cancer. This cancer can be dropped significantly. You can take away the fear.
1:29:42People now put it on the shoulders. I know what to do. How to do it. I'm going to follow this. Will it work for everybody? No. It will help a lot of people. Much more than what we have today. But it's paradigm change. Massive paradigm change. So they will come to know. It's just a matter of time. I don't know how long it's going to take, but I ain't going anywhere. I'm continuing to do this. I'm going to get better and better results. I'm going to keep pushing. I've published these case reports in the scientific literature. Let the scientific field make their decision on the results from these papers.
1:30:12And if you want to succeed, what happens? People improve. I'm not going to live forever. But I know that what I've done with following Otto Werberg and cleaning up the misconceptions and misunderstanding of why he was stalled when the field ran off Chase and Jeans. We've got to bring it back on track. It's a metabolic problem with metabolic solutions. So that will help a lot of people. But it's also going to change a lot of way people are thinking about this. But I can tell you, they want to open clinics. I get calls from Asia, Africa, South America. They want to open clinics. People are being brutalized by a system that's not working.
1:30:52Don't forget, besides the terrible financial talk, the personal physical toxicity, people are going bankrupt. Their marriages are falling apart because they can't pay for the expensive drugs on these cancer things. And they die and the bills are passed on to their love. This is immoral stuff. Is there a particular case study that's broken your heart more than any of this? Trudy Dupont, who originally let me... We built a glucose ketone index calculator on her. Pablo was still devastated by Pablo's loss because Pablo was a guy that I've known for 10 years. He worked him through and then all of a sudden he gets a cerebral hemorrhage and dies.
1:31:32He was our poster chaffer. How long you could live with a glioblastoma on metabolic therapy? But he didn't die from the cancer. You have this, some others that we wish they could have lived a little bit longer with the appropriate help. What I find is that sometimes within the family, there's a lot of... The guys, I really want to do what you're doing. But my wife and kids say I'm foolish to do that. So it's still a very... We're in a very early stage of this. We haven't really worked it out into an effective standard yet. It will come. So people... And the other members of the family get super help.
1:32:08When they all work together and they do it, everybody says, I can never felt so healthy in my life. Guy Tonobom had prostate cancer. He wrote a book and he's on the web. And he had hypertension, high blood pressure, overweight, more obesity, it, or everything. And then he does 18, several 18 -day water -only fasts, got himself. Everything, all these things went away. Diabetes went away. He's hypertension, high blood pressure. And the cancer can't be found. So is he cured? I have no idea. But he's managed? Yes, he's managed. And he's healthier. So what's wrong with that? Isn't that... Ultimately what medicine wants to do?
1:32:44Keep people alive longer. And a healthier quality of life? How many more do we need? They so has a fluke. That's a fluke. That's a fluke. That's a fluke. How many damn flukes do you want? If there's someone listening now, and I'm sure there's going to be many thousands and tens of thousands of people listening, that are currently battling cancer, have early stage diagnoses. I don't know. I feel bad about this because people say, Oh, I want to do medical therapy. Where can I go? And they go to their local hospital and get slapped out. There's no evidence. There's everything that should have come out of my mouth has never been taught to me in medical school.
1:33:18So what do you say to those people? You know, I say... I say... I'm sorry that the medical establishment has not come to recognize what I'm saying. And then I tell them, right? You know, the change has to be coming from the people. I ain't going to come from the top medical schools. They are doing what they're doing. The status quo is very profitable. The status quo is very effective for these people, but it's not helping the cancer patient as well as it can. And don't forget, we're not throwing out all this stuff. We're just asking people to know how to use the tools we have in a better way. We don't have to throw out immunotherapies radiation.
1:33:56We don't have to throw out toxic poisons. We just have to know better how to use it when the patient is in this new state. And the data will prove it. But who's going to do that? Who's going to do that? The doctor says, I'd love to do this. But I'm going to lose my license if I do it. What's going on with that? They wrote the standard of care as if it were in granite. Can't be changed. No, it should be flexible. When new evidence comes, I don't believe your evidence. What number do you not believe? What piece of science do you not believe on this? Well, I haven't read it. You can't be right when 99 % of the world says it's this way, and you're saying it's something different.
1:34:31That's confirmation bias. You're not looking at the numbers. And then when they get cancer, they come to you, what can you do for me? It's like that. But yes, it has to change. It will change because we're on the momentum to move it. People are coming to know this. And once the change happens, it's going to be like a major, a major chair. And people are going to have to just readjust. Thomas, we have a closing tradition on this podcast where the last guest leaves a question for the next guest, not knowing who they're going to be leaving it for. And the question that's been left for you is, imagine the end of your life.
1:35:06Your closest friends and family are at your funeral. What do you imagine or hope they say about you?
1:35:17He changed the course of cancer treatment for the world.
1:35:26It, that's it. Dr. Thomas Seafried. That is exactly what you're doing. And I think that's an extremely, you know, I can't even find a word that describes the profundity of such a mission. Because so many people are struggling with cancer as if it is this sort of opaque black box of a disease that strikes us at random and picks on people like Ruler and debilitates their lives out of the blue and having more information out there about the root causes of these issues turns the lights on and allows us to go in search of better solutions to what has always been a really, really complex, hard to understand disease.
1:36:05Your work runs almost entirely, I believe, on philanthropic donations, right? That's right. So that's people that, um... They make donations to both my university, Boston College, which is a Jesuit University in Chestnut Hill, Massachusetts. And we, we follow the Jesuit philosophy of service to others predominantly. And private foundations. So someone wants to make a donation, where do they go? Do they go to your website? I know there's a donation button there. They go primarily to our university. They can just... On my university biology webpage, there's a donation button. And Travis Christofferson's foundation for metabolic cancer therapies, which is a 503 foundation.
1:36:48He supports our research through philanthropic donations to his foundation. I would urge anyone that wants to support your mission to go to your university website. There's a donation button there, which I saw earlier on. Click that button. And they can make a donation if they... That's right. And, and, and, and, and Travis Christofferson's foundation, okay, which is the foundation for cancer metabolic therapies. It's a 503 foundation. Travis Christofferson's. When people email me, I send them the links to those, those found there. I cannot accept personally any money from anybody. Okay, it's one thing.
1:37:22It's one thing I'm not here. So people say, oh, I want to give you money to do it. No, no, no, no. I can't. You have to give it to the university to come through me through the appropriate channel. I can support my research through the university. Dr. Thomas Seafry, thank you so much for your time today. And I'm, I'm hugely inspired and enlightened by everything we've discussed. And I think there's a bunch of very straightforward practical things I'll be implementing in my life, specifically buying one of those bloody machines that I can keep on my GK index. Yeah, GKI. GKI index. Yeah, Glucos Quito and index.
1:37:52Well, listen, thank you very much for having me here, because your, your programs and others alert people to know that there are alternatives, effective alternatives. And once the system changes, the outcomes will not be so bleak as we currently have them today.
1:38:14Is this cool? Every single conversation I have here on the diorevasio, at the very end of it, you'll know, I asked the guest to leave a question in the diorevasio. And what we've done is we've turned every single question written in the diorevasio into these conversation cards that you can play at home. So you've got every guest we've ever had, their question, and on the back of it, if you scan that QR code, you get to watch the person who answered that question. We're finally revealing all of the questions and the people that answered the question. The brand new version two updated conversation cards are out right now at the conversation cards .com.
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From the publisher
Could fighting off the most feared and deadly disease be as simple as controlling what you put on your plate? Here is the revolutionary cancer care advice you’ve never heard.
Dr Thomas Seyfried is a Professor of biology, genetics, and biochemistry at Boston College. He has over 150 peer-reviewed publications and is also the author of books such as, ‘Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer’.
In this conversation, Dr Thomas and Steven discuss topics such as, the link between blood sugar and cancer growth, how stress management impacts your cells, the biggest misconceptions about cancer, and how calorie restriction could prevent cancer.
(00:00) Intro
(01:59) What Would Dr Seyfried Say He Does?
(02:37) How Much Of A Problem Is Cancer Globally?
(04:30) What Types Of Cancer Are People Dying From?
(05:02) How Many People Will Develop Cancer?
(06:56) Where Does Cancer Rank In The Probabilities Of Taking My Life?
(08:12) What Is The Fermentation Process?
(12:16) How Have You Arrived At This Conclusion?
(16:52) Why Do Cancers Grow So Rapidly?
(19:17) What Are Ketones?
(21:23) What Can We Learn About Cancer From Our Ancestors?
(24:36) What Role Does Exercise Play In Fighting These Diseases?
(25:44) What Lifestyle Choices Are Causing The Cancer To Develop?
(29:07) Is Cancer Genetic?
(31:09) How Do We Keep Our Mitochondria Healthy?
(32:42) Is Cancer Genetic?
(36:27) Why Haven't Opinions Changed Based On Dr Seyfried's Evidence?
(38:27) If We Adopt This Mindset, What Will Happen To Cancer Statistics?
(39:17) Are The Current Cures Working?
(41:50) The Current Technologies Used To Prevent Cancer
(49:10) How Do We Prevent Cancer?
(51:06) Should I Be On A Keto Diet?
(54:57) Dr Seyfried's Dog Study
(57:14) Human Cases Of People That Have Followed Your Research
(01:03:39) What Is Metabolic Therapy?
(01:04:36) What Should Someone That Has Cancer And Is Listening To This Do?
(01:07:52) Keto Plus Hyperbaric Oxygen Study
(01:11:57) Can You Have A Pre-Disposition To Cancer?
(01:12:28) Should I Restrict What I Eat, To Stave Off Cancer?
(01:13:16) What's Your View On Fasting?
(01:13:58) How Do I Get Into The Keto State?
(01:17:10) Do We Need More Discipline?
(01:18:36) What Happens When You Fast?
(01:20:52) What Advice Would Dr Seyfried Give To His Kids?
(01:22:14) Why Isn't Dr Seyfried Trying To Be Metabolically Perfect?
(01:23:04) What Food Laws Would Dr Seyfried Introduce?
(01:25:18) Is Dr Seyfried Hopeful?
(01:28:14) And What If You Are Successful?
(01:29:10) Are There Any Studies That Have Broken Dr Seyfried's Heart?
(01:30:50) What Would Dr Seyfried Say To Someone Listening?
(01:32:55) Guest's Last Question
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