The Man Behind Coinbase: Interview with Brian Armstrong | KMP Ep.52

25 Aug 2026 · 50 min · 25 chapters

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In short

Coinbase CEO Brian Armstrong argues that economic freedom is “foundational to all freedoms,” and that crypto needs clear U.S. legislation (Clarity Act) to prevent overreach and enable innovation. He also discusses why he co-founded New Limit to pursue epigenetic/cell reprogramming to extend healthy lifespan, plus his views on AI, corporate politics, and personal longevity habits.

Guest backgrounds

Brian Armstrong is Coinbase’s CEO; Coinbase went public in 2021. He previously worked at Airbnb (early employee around 2009) and started building Coinbase while there. He co-founded New Limit for aging research. The host is Katie Miller (KMP).

Key claims

The prior Biden-era SEC approach was an “active campaign” to curtail crypto; self-custody gives “ultimate sovereignty” against debanking. Clear rules are needed, unlike AI which should move fast like the early internet. Longevity progress is plateauing; aging is driven by loss of cell function, potentially addressable via reprogramming.

Notable examples

stablecoins (USDC) as regulated payments; Canadian truckers debanked; Reuters example of Merck melanoma work using mRNA-driven reprogramming; exercise/sleep as “longevity drugs”; banking stem cells; creatine and cholesterol management.

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

Tap a time to open that second in VO

The Intersection of Money and Free Speech

0:00 to 1:18

Exploration of the connection between economic freedom and free speech.

“Do you think the ability to control your own money is free speech?”

Legislative Progress on Crypto

1:25 to 2:58

Discussion on the efforts to pass the Clarity Act and regulatory environment for crypto.

“Well, the president is convening a group of people to get the Clarity Act over the finish line.”

Understanding Crypto and Its Misconceptions

2:58 to 6:12

Brian Armstrong explains what crypto is and addresses common misconceptions.

“people out there actively fighting against this.”

The Evolution of NFTs and Meme Coins

6:12 to 7:20

Discussion on NFTs, meme coins, and their potential future impacts.

“What happened to NFTs and where have they gone?”

The Future of Crypto and AI Regulation

7:20 to 10:34

Debate on the need for regulation in crypto and AI, and the implications for innovation.

“It's changing payments, like we talked about with stable coins, making that efficient all over the world.”

Brian's Experience at Coinbase

10:34 to 14:00

Brian shares insights from his career journey and decisions at Coinbase.

“So I think in this case, clear rules like with this Clarity Act coming up for a vote on September 15th, it's almost going to protect us from bad government with clear rules.”

The Political Landscape of Corporate America

14:00 to 17:00

Explore the intersection of corporate missions and political involvement in business.

“And then we were all aligned going forward after that.”

Cryptocurrency and Political Recognition

17:00 to 20:20

Brian Armstrong discusses how politicians are recognizing the importance of crypto voters.

“And, you know, luckily, cooler heads prevailed, or at least we're on a better path now.”

Regulatory Challenges Facing Crypto

20:20 to 23:00

An in-depth look at regulatory pressures from politicians on the crypto industry.

“And that's where I start to get it just doesn't feel right to me.”

The Case for Economic Freedom as Free Speech

23:00 to 26:40

Brian argues the connection between economic freedom and the right to free speech.

“People are thinking about what is the biggest application of AI.”
Show all 25 chapters

Innovations in Longevity Research

26:40 to 28:00

Brian shares his perspective on aging and technological advancements in health.

“disease, but there's a root cause, which is your cells losing function as you get older, which makes us much more susceptible to disease in the first place.”

Population Trends and Longevity

28:00 to 29:00

Discusses declining birth rates and its implications on society and longevity.

“I think it's like 0.6 or 0.7 births per woman.”

Defining a Healthy Lifestyle

29:00 to 31:05

Explores the components of a healthy lifestyle, including diet, exercise, and sleep.

“But one of China's biggest problems was that one child policy.”

Sleep and Genetic Factors

31:05 to 32:25

Covers the significance of sleep, the short sleeper gene, and its implications for health.

“And like I get it, I get like a blood panel done every quarter.”

Biohacking and Longevity

32:25 to 34:03

Discusses various biohacking methods and personal experiences with health supplements.

“But oftentimes I'm excited to go build things.”

Stem Cell Banking Experience

34:03 to 35:39

Shares a personal story about banking stem cells for future health benefits.

“I'm paying like 4K a year for my kids' stem cells.”

Cultural Perspectives on Freedom

35:39 to 37:21

Explores how personal background shapes views on democracy and patriotism.

“We were at this event in LA and yeah, I just was captivated kind of.”

AI in Business Decisions

37:21 to 41:03

Discusses the role of AI in investment strategies and business operations.

“We're going to play our famous game now of Would You Rather.”

Philanthropy and Its Impacts

41:03 to 42:01

Questions the effectiveness of philanthropy and its potential negative consequences.

“Well, there's some, I don't know if this is true or not, but I think it's really funny to think about whether Justin Trudeau is Fidel Castro's son.”

The Challenge of Ideological Foundations

42:01 to 43:02

Explore the difficulties in establishing a foundation without ideological capture.

“And that's, I think a lot of people by trying to do something good, like maybe like criminal justice reform or something.”

Sponsoring a Video Game Championship

43:02 to 44:16

Learn about Brian Armstrong's unique sponsorship decision for a video game.

“What's the craziest thing you've ever spent money on?”

Morning Routines and Social Awareness

44:16 to 45:24

Discover insights on morning routines and social perception challenges.

“What's the first app you open in the morning?”

Understanding the Legislative Process

45:24 to 46:28

Gain insight into the complexities of passing legislation in Congress.

“This is part of the reason why a lot of entrepreneurs, I think, have a little bit of autism and they're willing to just go try things, which most people would be like, that's low status or it's weird, it's contrarian.”

Dinner Party with Historical Innovators

46:28 to 47:34

Imagine a dinner with renowned historical figures and discuss their impact.

“you'd have like a CEO kind of equivalent who is a single decision maker, but they created the balance of powers and the bicameral legislature and everything.”

The Wright Brothers and Belief in Possibility

47:34 to 49:54

Reflect on the Wright brothers' journey and the importance of innovation.

“If you could host a dinner party with three people that are alive, who's sitting at the table, and what are you eating?”
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Transcript

Automatic transcript. May contain errors.

0:00Katie Miller:Do you think the ability to control your own money is free speech? Oh, yeah, absolutely. I mean, economic freedom is kind of like foundational to all freedoms, because think about it. Let's say you in theory have freedom of speech, but someone can debank you or seize your assets. You're not going to be very willing to go actually exercise your right to free speech. Right. But there seems to be a lot of fraud and waste, which is just so it's like an unconstitutional asset seizure and then going to fraud. And that's where I start to get it just doesn't feel right to me. It's against my values. I would say I think it's bad for the state.

0:30and for America. My worldview is that technology is a great way to improve the world and we should all try to go build companies.

0:35Katie Miller:Do you think AI is going to cure cancer? Yeah, eventually. So Coinbase is great. We went public in 2021. I finally got some liquidity and I was thinking like, okay, how do we go help the next big problem and help fix the next big problem in the world? How do we actually like double expected lifespan? I mean, if you go back 100 years, people in the US, the average life expectancy, I think was like 35 or something. And now we've more than doubled it. What's your favorite coin? Well, Bitcoin is the original. I think that's great. And then, you know, things like USDC, like stable coins have been incredible.

1:05That's the top regulated stable coin in the world now that we have a role in.

1:17Katie Miller:Hi, everyone, and welcome to this week's episode of the Katie Miller podcast. We're excited to be in Washington, DC today with Coinbase. How's it going? Great. Thanks for having me. What are you in Washington, D.C. for? Well, the president is convening a group of people to get the Clarity Act over the finish line. And, you know, there's we're meeting with the regulators, Chair Atkins and Chair Selig. They've been making a lot of good progress about publishing clear rules for crypto. And now we've got to get legislation passed to make it durable and cement it so that it can stand for many decades into the future and can't get changed by some future administration.

1:50Katie Miller:You've been at this, though, a while. This isn't new. Yeah, we've been working on legislation for crypto for years at this point. So what's the difference between the last administration, this administration, how close you actually think you are? Yeah, well, I mean, if you go back to the 2024 campaign, the president very astutely recognized that there were millions of Americans who felt disenfranchised by that prior administration. And their kind of attack on crypto, you know, Gary Gensler especially was a very unpopular figure. The president very famously at this Bitcoin conference on the campaign trail, he said, on day one, I will fire Gary Gensler.

2:23And it was like the biggest applause line. I think even he didn't expect it. And he said it again. And, you know, he's lived up to his promise, right? A promises made promises kept that whole line. So in the first few weeks of him taking office, he put out this executive order asking his administration to go create clear rules. He then appointed chair Atkins and chair Selig, two of the most competent and pro innovation regulators anywhere in the world. And then of course, the administration passed the genius Act last year for stable coins. And so now we've got an opportunity to do the second piece of it with the Clarity Act and get that over the finish line.

2:56And, you know, make no mistake, there are people out there actively fighting against this. There's entrenched incumbents who don't want competition from crypto companies that would provide better financial services. And so some of them are actively lobbying against it, trying to kill it. There's senators like Elizabeth Warren who are out there trying to kill it.

3:14Katie Miller:So there's not many things Elizabeth Warren likes, though. That's true. I mean, so anyway, you're on the right side of history, maybe, if she doesn't like it. I think she wishes the government was running all financial services or something like that. So if you break it down for the person who's like, what even is crypto? I don't own crypto. Or I've tried to open crypto, and then I got confused with the wallet, and I clicked out, and I was like, no thanks. Yeah. That's where I am. Yep. So if you start at the beginning and say, what you guys are is like the bank for all cryptocurrencies, right?

3:42Something like that. We don't have a bank license, but we're - Similar. Metaphorically, yes.

3:45Katie Miller:How do you decide what crypto is accepted versus not? Well, OK, so you're right, by the way, a lot of people are still learning about crypto. And it started with Bitcoin, which is kind of like digital gold. Now we see people using stable coins. I think in the future, people aren't even going to really know they're using crypto. It's just a faster, cheaper, more efficient financial way to access financial services, whether you're doing payments or you're getting a loan. Why is it faster? Well, because it's built on modern rails, right? Like the legacy or traditional financial system was really kind of invented around the 1970s.

4:18A lot of the mainframe computers, it's still being run on this like very outdated system. And that's why you can't send money over the weekend. And there's high fees to send a wire or the average merchant.

4:28Katie Miller:What do you think that like AI could solve some of their coding issues and bring Wells Fargo, Bank of America, some of the big banks up to a better standard instead of saying running on COBOL? Yeah, well, AI is making every organization more efficient, including the banks and the folks who run kind of that legacy infrastructure. So I think that will help. But there's a lot of reasons why it's not moving fast that have nothing to do with, like, if it was purely a technology problem, I think it would get solved faster. In some ways, they like the inefficiency of it because they can charge high fees for it.

5:01And it's hard for big established institutions to change unless they have new entrants coming in to create competition.

5:07Katie Miller:So what's a meme coin? Well, a meme coin is something, it's really got created in part due to the lack of regulatory clarity in the US because you couldn't, there was no clear pathway to say raise money for a company on chain like a true security. And so people started trading these meme coins and it was really like, some people call it an attention market. It's like, what are people interested in right now? Now, there was a bit of an unsavory element to it in the sense that these groups of people, some of them would try to like pump these meme coins and dump them. And so like there was a I would say there was aspects of it that were unsavory.

5:42But I think the idea of it is probably going to persist. And there could be a next generation of meme coins like actually, you know, memes are great. Like that's kind of the modern day political cartoon, you know, going back to Benjamin Franklin, you know, join or die or like these famous political cartoons. A lot of ideas can just be like, you know, it takes a thousand words to explain it and no one reads it. But if you see a really funny meme on X or something like that, an idea can go all the way around the world and really stick. So there might be some way that the next generation of meme coins taps into that.

6:12Katie Miller:What happened to NFTs and where have they gone? Well, NFTs are still here. I mean, I think people aren't trading as much like, you know, these bored apes and things like that. But the idea of an NFT is actually broader than that. It's really any kind of, you know, Bitcoin, we'd say, is like a fungible token, meaning any one Bitcoin is exchangeable for another one. They're identical. NFT is like a unique digital item. So these could be used not just for artwork, but also for, say, like governments to issue an ID or a license or a credential, like a university diploma or something like that. Like these could all be.

6:45Katie Miller:So it would just be on your cell phone? Well, yeah, I think in the future, people will have this identity that they control and it can have certifications and attestations attached to it, which would be NFTs underneath. People may not call it that, but the technology is pretty broad. What do you think the biggest misconception is people have about crypto?

7:07I think it's that, you know, they think it's kind of for libertarians or anarchists or something like that. And that's like an outdated view. I mean, I think some of the early adopters of Bitcoin were like that. But crypto is now updating every aspect of the financial system. So it's not just a Bitcoin thing. It is. It's changing payments, like we talked about with stable coins, making that efficient all over the world. It's doing things like prediction markets, which help people figure out what's going to happen next, borrowing and lending, and even things like tokenization of real world assets, like stocks are getting tokenized now, all kinds of different funds.

7:42So it's really updating every aspect of the financial system. And that's something I think people haven't fully realized yet. By the way, agentic finance is going to be a big thing, too, because AI agents need to do real time small transactions all over the world. I think there's going to be more agents than humans in the world. And so we need a new financial system for them. That's a whole nother thing that's going to be solved by crypto.

8:02Katie Miller:Do you think that the AI agents will be nefarious in terms of taking someone's money or being abused by somebody, if not properly regulated as well? Well, I think with any new technology, it can be used for good or for bad, even going back to fire or something like that. The invention of fire or discovery of fire. So I think that the good news is that roughly my mental model is like 99 % of people are good. 1 % of people are trying to do something bad. As long as regulation can help in certain instances. But I actually think free market competition is like sometimes the best regulator because it gives people choice about which one to go use.

8:39And assets accumulate to companies and products and services that are trying to do things that are good in the world and providing better products at lower prices. So anyway, I'm a favorite of free market competition. Regulation can sometimes help, but there's a danger in overdoing it.

8:54Katie Miller:Because Dario over the weekend had said that, you know, they tried the regulation route. Now he wanted to do something with an executive order versus having, say, national legislation or state based legislation. You're pushing legislation for crypto. Where do you think AI should land and why do you think crypto should be regulated then if not AI? Yeah. So this is a great point because I think AI, I think of it a little bit more like the internet. Like part of the reason the biggest technology companies in the world have been created in the U.S., which is a huge boon for American, you know, soft power around the world, et cetera, like, you know, Google and Meta and all these companies, is that the internet was largely unregulated, right?

9:31They allowed the market to go create these things and move fast. I think AI should follow more of that model. So far, we've had lots of frontier labs competing, and there's all these kind of hypothetical things people could come up with that are dangerous, but honestly, none of them have happened yet.

9:46Katie Miller:So when Anthropic or OpenAI say that their model broke into the sandbox or escaped the sandbox and did this bad thing or mythos could be that scary, do you believe that? I think that those are accurate statements. I think, by the way, they're also a little self-serving because it's great marketing for their product. But the reality is human beings do that, too, right? There are instances of human beings who try to do something nefarious within an organization. So, you know, just because you say, oh, well, this AI model, it lied to me. I'm like, well, human beings lie sometimes, too, and the world didn't end.

10:20So that, to me, is not like a good argument that we should just, you know, slow down all progress on AI. I think, just to answer your prior question, crypto is in a little bit of a different situation because we're already dealing with 100 years of financial services regulation. And the lack of clarity has really held back progress and actually got weaponized like in the prior administration. So I think in this case, clear rules like with this Clarity Act coming up for a vote on September 15th, it's almost going to protect us from bad government with clear rules. So I think that that's an important distinction.

10:51Katie Miller:You started your career at Airbnb? Yeah, well, you can go back as far as you want. But I did work at Airbnb, yeah, around 2009 or so. How, when you decided to start Coinbase in your 20s, what did you take from working at other startups and moving that into yours? And what was the decision when you're like, this is going well, or I seem to have made it, this idea works? Yeah, well, you're right that, I think it was 2010, actually. So I was an early employee at Airbnb. I tried doing a startup previously, by the way, in college. And it was like, it was in the education space, tutoring. I would say it didn't go super well.

11:25was kind of like a base hit. I had a small exit from it, but it was not a success. And so I joined Airbnb early on because I wanted to see what it was like to have a successful startup or be a part of it. I learned a lot from them. They had an incredible bar for talent. That was one thing, is like, if you're not a hell yes, you're a no on a candidate. They really had a high bar for design and quality of software engineering and then this incredible culture that they had created. And so there was something, it's actually oftentimes very powerful, I think, for people to get around. If you just read about people on the internet, sometimes you put them on a pedestal and they're like, oh, they're some genius and I could never do that.

12:00Working every day with these folks, you realize they are very talented, but they're made of the same stuff that you and I are made of. And this is possible. This is doable. It kind of gave me a little bit of confidence. And so when I first read the Bitcoin white paper, I started to think about that and sort of nights and weekends started working on a prototype for what would eventually become Coinbase while I was at Airbnb. And when I did leave to finally go do it, I took some of those best practices, and I think it helped to make Coinbase successful.

12:25Katie Miller:Back in 2020, you had famously said to your employees, we're not here to be a political company. We're here to just work. Do you think that was the right decision at the time? Absolutely. Yeah. I think in hindsight, it was one of the best decisions I ever made as a CEO. And it was a very contrarian view at the time, of course. We got lots of attacks for it. But yeah, in that zeitgeist, that moment with with George Floyd and all these kind of COVID where people weren't spending as much time together in person, this kind of anger or like, you know, lack of unity, like really bubbled up where - It's hard to do in San Francisco though.

12:58Yeah, I mean, the culture of San Francisco can be a little odd at times. It has like the most innovative companies in the world and a huge like group of people who think communism is great. It's like, it's a weird place. Polycules, you know, all kinds of stuff. You know, but yeah, that was the first time as CEO, I felt like the employees had really revolted. There was a walkout that happened and there was lists of demands that were being sent to me. And I was very confused at first because I was like, well, the mission of our company is to increase economic freedom in the world. We're working on crypto stuff.

13:29Why are you asking me all these questions about gun violence or whatever, police brutality or something? I'm like, there's a lot of problems in the world, but we're trying to fix this one over here. So maybe we should just focus on that one while we're at work. If you guys wanna do stuff outside of work, great. You can have whatever views you want. It was obviously the right call, but at the time it was very controversial. You know, we got lots of attack pieces written up on us by various traditional media companies and things. And about 5%, we offered an exit package. Like anybody who's not aligned with this path going forward, here's a nice exit package you can leave.

13:59About 5 % of the company left. And then we were all aligned going forward after that. So it was important.

14:04Katie Miller:Do you think corporate America is too political? I think that if it's related to your mission, it's fine to be political. I think that there are another set of companies that, frankly, their mission is not that inspiring. Like, they're just selling, I don't want to make fun of anybody in particular, but, you know, they're selling some piece of software that's just, like, boring or kind of like a utility. So they tried to engage their employee base on some broader issues outside of that mission. And it's tempting to do that, but then you get sucked into every debate is like, well, where do you land on Israel-Palestine?

14:40Where do you land? You know, and it's like just a distraction. So I think it's better to make a company that truly has an important mission and just get people engaged on that. And then you don't have to sell this kind of like virtue signaling luxury belief stuff on the side.

14:55Katie Miller:What's something President Trump understands in relation to crypto that former presidents didn't or that other politicians just don't get? Well, yeah, you have to give him a lot of credit because was during the 2024 campaign, he very astutely recognized there was a massive voter base of people who felt disenfranchised by that prior administration. So like millions of crypto voters, people now realize. And by the way, on the opposite side, like who's the anti-crypto voter? Like nobody, there's no anti-crypto voter. It's like they have other things that they care about. Maybe they don't like crypto, they don't care about it, but they don't vote on it.

15:28Whereas the people who are really into crypto, they're really into it. And they were so mad that they felt like they were being attacked unfairly, unlawfully. And so, yeah, the president recognized that. And he also recognized, by the way, it wasn't just like a good political opportunity. He recognized that for the United States to stay relevant as a financial and technology hub, we have to embrace these new technologies and figure out a way to bring them within the U.S. regulatory perimeter. Because if not, it's all going to go offshore. And then it's not like you can un-invent crypto at this point, right?

15:58Like someone is going to do it in the world. You can't just bury your head in the sands. So whether you like crypto or hate crypto, you got to put clear rules in the book so it can be built here in America.

16:07Katie Miller:You were outspoken about the way Gary Gensler and the Biden administration treated crypto. Do you think they're trying to regulate you guys out of business, trying to pretend crypto didn't exist? Yeah, it wasn't just pretending we didn't exist. I think it was an active campaign to try to curtail or even kill the industry in the United States. I think that, you know, I think folks like Elizabeth Warren believe that the government should run financial services. She had lots of influence with the financial regulators at that time by basically applying soft pressure, one might say extrajudicial pressure, because it was not illegal, let's say, for a bank to give a loan to an oil and gas company or a firearms company.

16:48It was not illegal, but Elizabeth Warren, through extrajudicial measures, could go pressure the bank regulator to go in for their audit. And crypto was seen as a threat to that. And so that's partly why she didn't like it. And, you know, luckily, cooler heads prevailed, or at least we're on a better path now.

Read the full transcript

17:05Katie Miller:Do you think the ability to control your own money is free speech? Oh, yeah, absolutely. I mean, economic freedom is kind of like foundational to all freedoms. Because think about it, let's say you in theory have freedom of speech, but someone can debank you or seize your assets, you're not going to be very willing to go actually exercise your right to free speech, right? And that has happen with people in various cases. Famously, the Canadian truckers got debanked and deplatformed that way. Many people, including the president himself and his kids, got debanked in the United States. You can't get debanked from crypto though, right?

17:38That's right. If you have -

17:39Katie Miller:I'm asking this as a genuine question. Yeah. If you have a self-custodial wallet, that is the ultimate sovereignty because literally, if you have a phone, an internet connection anywhere in the world, you can get access to this and have assets in a way that is truly property rights. Like nobody can take it from you. What's your favorite coin? Well, Bitcoin is the original. I think that's great. And then, you know, things like USDC, like stable coins have been incredible. That's the top regulated stable coin in the world now that we have a role in. What's your favorite meme coin? Well, I love lots of memes.

18:12There's not like, the problem is if I say one in particular, it's going to be like, yeah, I mean, so I don't want to be seen as like pumping any of these in particular, but I do think there's been a particular fascination with my dog for some reason. And I do think it's funny that people create coins around that. And I'm not endorsing any of them, but I think it's funny.

18:35Katie Miller:So what's what's your favorite NFT that you've seen? So well, I actually just recently bought a Crypto Punk, if you know what that is. I don't. OK, well, these are kind of like some of the most original, the early NFTs on the internet and they were basically like profile or identity like characters and there was 10 ,000 of them and they were given away for free. Anybody could claim them. And now they trade anywhere from like 50 ,000 to$20 million each. And they're like, anyway, they're kind of like these, they're kind of like the Mona Lisa of the digital art world, if you want to make that analogy.

19:09So I think those are interesting.

19:10Katie Miller:What do you do with the digital art? Like, what do you do with it? Well, you can use it as your profile photo on the internet and people feel some sort of affinity to it if it represents who they wish to be online. Got it. Yeah. Why do you think so many tech founders are leaving California? You've seen the billionaire tax. What are you personally doing? Have you worked to fight against it? Yeah. I mean, it's the wealth tax, right? I think it's deeply un-American to seize people's assets. It might be unconstitutional. You know, we all benefit from various things in the United States enormously and we should pay taxes.

19:49I don't have an issue with that. I've paid tons of taxes on profits and income. But after you've already paid your taxes, they want to come take another tax from you and seize your assets. That to me starts to feel like a third world country that is a dangerous, dangerous path to go down. And if I thought they were going toward good outcomes, especially like in California, I wouldn't be so opposed to it, like if it was being well managed. But there seems to be a lot of fraud and waste, which is just so it's like an unconstitutional asset seizure and then going to fraud. And that's where I start to get it just doesn't feel right to me.

20:28It's against my values, I would say. I think it's bad for the state and for America. So we're considering any all options basically at this point to be in terms of relocation.

20:38Katie Miller:Ro Khanna had said for founders that he was going to take a percentage of, you know, say their assets were held in a stock instead of in cash, that the government could take some of the their percentage as well. Yeah, I mean, you go down a very dangerous path with that. I mean, just think for a minute about the way it's architected. So how do you even value all of these people's property, right? Can you imagine some government bureaucrat coming in and, you know, hey, how much is that necklace worth? How much is that lawnmower worth? I mean, these are matters of opinion. And the way it's currently drafted, you have to basically have an auditor come in and value all these things.

21:19And if they get it wrong, they're criminally liable or they're personally liable. So every auditor is going to sandbag it and put in all this kind of buffer. However, it just, you get into a, this starts to feel very third world to have the government coming in and seizing your private property. I think it's, it'd be a terrible precedent. You know, the political wins are such that in California, this could genuinely pass though. I mean, I think there's probably people in my own family who might vote for it, right? So it's just, if you see something on the ballot that says, hey, should billionaires pay more tax?

21:49Everyone's like, sure. But they don't think about the second and third order consequences of that. And by the way, it's not just going to be billionaires. They're already talking about it going down to 50 million. And so if you're an illiquid tech founder, I think people have this misconception that tech founders or billionaires have like billions of dollars of cash just sitting around. Most of the people who are billionaires are on paper and all of their net worth is tied up in like a private company stock that's illiquid. So, you know, you might raise$50 million for a company that now has a$2 billion valuation.

22:22And on paper, you're a billionaire, but you have like$2 ,000 in your bank account. So to pay this tax, you're going to be a forced seller of an illiquid asset. Like most of these founders are going to have to just move out of California. And it'll put a huge deficit on the state that is already overspending. So it does not bode well for California.

22:40Katie Miller:You've made billions building a crypto company and then you decided to fight human aging. Yeah. Why? And what's your hack that you found that works the best so far? Yeah. Okay. So, I mean, just zooming out, my worldview is that technology is a great way to improve the world, and we should all try to go build companies. Do you think AI is going to cure cancer? Yeah, eventually. Yeah. And AI is playing a huge role in this. These are all synergistic. People are thinking about what is the biggest application of AI. The biggest one I can think of is how do we get more years, more healthy years, right, and actually cure aging at some level.

23:15I think too many young people today are getting enamored with the idea of becoming an activist and being taught that this is like a virtuous thing, it's actually very easy to be a critic and it makes you feel important and smart. You might get to go to some rallies with some people and make some friendships. But at the end of the day, like you're not oppressed, okay? You live in the greatest country in the world. You have all these freedoms and you could do something useful with your life and try to contribute. And to be in the arena is hard. It's hard to go build something useful and help your fellow man or woman, right?

23:43And so I have a lot more respect for people that actually go try to create something new in the world. And that's what I was trying to do was live that motto myself. OK, so Coinbase is great. We went public in 2021. I finally got some liquidity. And I was thinking, like, OK, how do we go help the next big problem and help fix the next big problem in the world? I hosted some dinners with friends. And we were talking about all kinds of brain machine interfaces and space and fusion energy. And one of the biggest areas that I felt like was underfunded, there's good teams working on a lot of those things.

24:14Aging is something that people, I didn't see good teams working on it. I thought it was underfunded. And we needed to come up with, okay, is there a way to actually tackle this? Because a lot of the people working on it were doing snake oil. It had a low reputation, I would say, longevity in general. I mean, there's things that everybody can do that are just like exercise and sleep. These turn out to be very effective. If there was a drug on the market called exercise, it would probably be the most effective longevity drug out there. And the good news is it's free. You can go for a walk and you can sleep a little bit more.

24:45And everybody has access to these longevity drugs. But I was thinking, okay, how do we actually double expected lifespan? I mean, if you go back 100 years, people in the US, the average life expectancy, I think, was like 35 or something. And now we've more than doubled it. We did that, by the way, by discovering things like washing our hands with soap and And, you know, things like penicillin, antibiotics, like, so these things. Filtered water. Yeah. I mean, these things really actually doubled. We doubled life expectancy, okay, over the last 100 years. But recently, it's kind of started to plateau.

25:18And how do we get that next doubling? The best idea that we have, and this is why I co-founded this company, New Limit, along with other folks. It's about this thing called cell reprogramming or epigenetic reprogramming. And just the brief piece on that is that, you know, all of our cells lose function as we get older. And the genes that were on in a certain cell, some of them get flipped in the wrong way. Like a gene that should be on gets flipped off or vice versa. And so we slowly lose this function in our cells. We've now shown, and other labs have shown, that you can reprogram cells to restore function they had when they were younger.

25:52Katie Miller:Well, isn't that exactly what we saw today? I don't know if you've seen this, so sorry. But Reuters came out with a report that says Merck has a new vaccine for melanoma in which it's reprogramming through an mRNA vaccine, your own cells to be able to fight melanoma. And it's showing pretty much it's secure for a melanoma. Yeah, that's a great example. And if you look at all the major diseases that take us out, whether that's heart disease, cancer, cardiovascular, diabetes, mental health, these all are highly correlated with age. Okay. And it's sort of an obvious, like when you're young, we actually get like cancerous cells in our body all the time.

26:30And when you're young, your body can recover from that and go kill off those cells. You get older and, you know, your cells lose a little bit of their function. And so it's not like, I think a lot of healthcare today, we're trying to go cure an individual disease, but there's a root cause, which is your cells losing function as you get older, which makes us much more susceptible to disease in the first place. So we're trying to solve the root problem of getting ourselves to act younger.

26:54Katie Miller:But don't you think that's the PFAS, all the microplastics, all of the chemicalization, diseases of civilization, you're talking about urbanization of our environment, like all of those things contribute. Yeah, well, it's true. I mean, when we're younger, though, we can recover from those insults to the body, right? And I think it's, I don't know if epigenetic reprogramming will cure like 100 % of all aging. It could be a multi-factor problem. But we, at least our hypothesis, is that we believe it is a, let's say, a material factor, maybe even a predominant factor. And the exciting thing is, this is with New Limit, the company, we've actually demonstrated successful reprogramming of human cells.

27:34We've done it in mice now who have humanized livers. And we are now getting ready for clinical trials in humans next year. So there's going to be a whole set of drug candidates that come off of this pipeline we've built, using AI, by the way, to test millions of hypotheses. And we'll bring the top candidates into the clinic, try five or 10 of those, and hopefully at least one or two of them hit.

27:56Katie Miller:When you talk about longevity, though, my brain immediately goes toward what we're seeing say in South Korea, where they have the world's lowest birth rate. I think it's like 0.6 or 0.7 births per woman. And they're having the oldest population at the same time. So there's no one to take care of their seniors. There's no one doing a lot because you have an older population and no young people anymore. And we're on that trend here in the United States as well, right? The birth rate's decreasing every year. We haven't plateaued. It's still going down. Yeah. So then if you're saying now we're going to live longer than ever, but we're not solving for the problem of having babies, then what?

28:29Katie Miller:And so to me, it's a multifaceted issue, not just longevity, but the fact that we don't have a birth rate that's sustaining population. Yeah, I'm right there with you, too. I think we should raise the birth rate. And, you know, sometimes when I talk about longevity, people will say, well, aren't you worried about overpopulation? I'm like, no, the birth rate is declining. So I think it'd be great if people lived twice as long and we should also fix the birth rate. I agree. The overpopulation argument that resulted in the one child policy in China is what's led to this declining birth rate, many things.

29:00Katie Miller:But one of China's biggest problems was that one child policy. Yeah, that was disastrous for them. Do you consider yourself maha? I don't know. I don't know. I mean, I'm certainly like pro-health. Do you want me to define it for you? Yeah, please. What would that entail exactly? I would say like no seed oils. Okay. Are we eating whole foods? Are you avoiding plastics where possible? Are we cooking with stainless steel? Yeah, actually all those things, yes. Okay. Yeah. So like I would consider that like do you avoid highly processed food? Yeah, of course. So that's what I would consider Maha. Yeah, sure.

29:37Katie Miller:I guess. What's your healthiest take then? In my own personal life? I mean, all of the, so I think there's like a, there's a foundation of things that everybody should kind of get in place, right. Which are, you know, it's, it's exercise, it's nutrition and it's sleep and let's say mental health. Um, and then there's a bunch of stuff you can go do beyond that, but I think the foundation should be there in place first. So, you know, I, I work out like in the mornings, like six days a week, do some stretching. I either do some cardio or some weightlifting. Um, and then I track my sleep and do all kinds of things, you know, that you can try to boost your scores on that and get enough, get like seven and a half hours of sleep or so on average.

30:20Um, and then, you know, I think like the mental health part is important too, because we can all be caught up in like the day of just fight or flight and opening your phone in the morning and looking at all the scary messages coming in and crazy debates happening. And it's important. In the morning, I really try to take about an hour to not look at that stuff. Do you have kids yet? Not yet. Yeah. That'll be a whole other way of meditating, I suppose, in the morning. But, you know, maybe not having your mind on work. Maybe there's like...

30:52Katie Miller:That's a different morning routine. Cheerios being thrown around or whatever, but at least you're not caught up in this. That's a different kind of meditation. But yeah, I think people should get all those kind of foundational things in place. But then, yeah, you can go further with it. And like I get it, I get like a blood panel done every quarter. And I just look at all the biomarkers. And I was with my doctor, I kind of tweak it a little bit. And why I'm a little deficient on this or I, you know, want to improve this one. So a seven and a half hours, the optimal sleep? It's person dependent.

31:21I mean, actually, one of the great things like, you know, appears like President Trump and other people have this short sleeper gene, which I think is understudied. There's actually, this is a fun story. I mean, do you know the short sleeper gene? Like some people genetically don't have to get as much sleep. It's not that they're just running around tired all the time. They can sleep three to four hours a night and apparently be totally fine. A lot of really high performing people have this. Arguably, Elon may have it. Like Indra Nui, who was the CEO of Pepsi, had this. There's other people. But I actually funded this study to see if you could induce the short sleeper gene into adult mice because it's interesting to think, like, do you need to have this genetic thing from birth and it changes the development of the brain?

32:05Or as an adult, could you have some therapy that could give you that short sleeper gene or phenotype? Because if it works in mice and we can induce it in adult mice, then I think it'd be cool to fund some research to see if... I don't know. I would personally love to have that gene. I think it'd make me more...

32:21Katie Miller:I love sleeping. Why would I give that up? Well, it's fun and you can sleep whenever you want. But oftentimes I'm excited to go build things. I just want to get more stuff done. So what's a trendy biohack you think is total bullshit? I mean, total bullshit is like a big statement. I mean, I've tried some of the peptide stuff. I think a lot of it is, some of it may work. I mean, GLP-1s are peptides also, by the way.

32:50So I think some of the stuff that's being done in compound pharmacies is not that effective. And a lot of it's placebo. Like people, you know, if you get like some sore thing at the gym and then you take these and then like three weeks later you feel better, you might have felt better if you had just not done anything or just rested a little bit and not gone so hard at the gym. So it's a little hard to tell. Anyway, most of those peptides that are done in compound pharmacies, I haven't seen like good evidence from a randomized control trial.

33:16Katie Miller:What's the craziest longevity thing you've tried? Let me think about the craziest. I mean, a lot of the stuff I do is pretty standard. I take creatine. Do you think creatine works? Yeah, there's good evidence on that. Creatine works.

33:39In my family, there's high cholesterol. And my grandparents passed away at a relatively early age from heart disease. So I've taken like there's statins are now like cheap and off patent to everybody. It's kind of like good therapy. There's newer ones like they're called like PCSK9 inhibitors and things like that. So anyway, my cholesterol is great. That was like a good one to finally get in there. OK, this is this is probably the craziest one I did. I'm not even sure I would recommend this, but just to be clear, but I banked some stem cells, which I believe there's a standard of care now, which maybe your kids went through, where I think they bank stem cells now from the umbilical cord.

34:18Katie Miller:I'm paying like 4K a year for my kids' stem cells. I'm not sure if we're going to use them. I have all my kids. When I just had a baby, I went into precipitous labor. I didn't know I was going to give birth that day. I didn't buy the stem cell kit that time. My husband was like, you got to do it. I was like, why? We already have three. Why do I need four? He's like, well, you don't want to let the fourth kid not have it. That's rude. I was like, great. My mom's like calling around to try to get this stem cell kit. We eventually get it. Don't worry, it's banked. But I'm like, why am I spending 4K a year for something I may never use for my kids' stem cells?

34:51Katie Miller:But don't worry, I have them all. Yeah. So that, I think, you know, at least when I was born, that was not the standard of care. And so I don't know if these will be useful in the future or not, but I'm just interested in health and longevity. So I went to actually go bank my stem cells when I was like 35 or something like that. And you know, they actually, it sounds like awful. They have to like drill this little hole into your hip bone because the inside the bone marrow is where you get like, and it was kind of pain. It was pretty painful actually. But anyway, I have, you know, the doctor warned me, he was like, on a one to 10 scale, this is going to be like a seven.

35:29I was like, let's do it. I'm, I'm It was rough. But anyway, but I did get my, so now I have these stem cells banked. Is it going to be useful in the future to develop custom therapies or something? I don't know. But anyway, I did that one. That was a little out there.

35:44Katie Miller:So where did you meet your wife? We were at this event in LA and yeah, I just was captivated kind of. So I heard that her and her family came to the United States after she was fleeing persecution. Well, she fled, her family fled communist China. Yeah. Wow. Yeah. And so is her family now here? or they're still in China? No, they're all here. Yeah. And she's a citizen and everything. So yeah, she's in some ways, she's actually more patriotic than I am because she's seen what the alternative is. A lot of Americans, I think, take what we have for granted. So yeah. Has their experience shaped the way you view freedom and democracy?

36:18Katie Miller:And has it shaped, you know, how you guys view things together? I know that like when my husband and I talk about things, it often shapes my world view. Yeah. Sometimes I radicalize him more than he radicalizes me. But how does that work for you? Yeah, there's many times where, you know, I think, like, especially in the past, like, when the prior administration, we were having all these issues with Gary Gensler and stuff, and I would sometimes be kind of critical of the United States, and I'm like, well, yeah, this, the government is doing this and that, and she was like, you have no idea how lucky, don't you dare say that, you know, and she was, like, going and reading the Federalist Papers, and, like, she's, like, you know, understands all the founding father stories, And then she was like, how dare you say that?

37:00Like, you live in the best country in the world. Like, is it perfect? No, but you at least can. She's like, you don't understand how much of a gift it is that you, as a private citizen, can go publicly criticize the head of the SEC. You're like, do you realize you would be put in jail instantly in China for saying that? Like, you don't. So anyway, she definitely made me more patriotic.

37:21Katie Miller:We're going to play our famous game now of Would You Rather. Okay. Would you rather have to explain Bitcoin to a five-year-old or explain meme coins to Congress?

37:32Either one sounds fine, honestly. I mean, I think explaining Bitcoin to a five-year-old sounds more fun.

37:38Katie Miller:How often do you explain Bitcoin on a daily basis? I mean, I used to do it all the time. Like, one thing I realized is, you know, if you, you might have been building something for 10 years, but there's still a huge swath of people who are just getting comfortable with it. So as a founder CEO, you kind of have to get comfortable with like preaching to the choir on a regular basis. And that's normal. Would you rather let AI manage your personal investments or let AI make all of your business decisions? I think AI agentic trading will become a bigger and bigger thing. And we're experimenting with this at Coinbase, like Coinbase Advisor.

38:14I don't think it's quite I'm not quite ready to hand over the reins on all my investments. But you got to pick. I do use AI, though, frequently to get input on business decisions. I think it's better there. So I'd say the business decisions.

38:26Katie Miller:Would you rather know exactly when you're going to die or exactly how you're going to die? I think when. It doesn't matter so much how. If you know when, I think it starts to create a lot of sense of urgency. Like, you know, Steve Jobs was working on the iPhone on his deathbed. Like, you know, arguably one of the people who worked on Bitcoin, who maybe one of the Satoshi Nakamoto is Hal Finney, and he was on his deathbed. So there is something powerful about knowing, like people say that, you know, live every day like it's your last and it's a cliche. But when it's really true, it focuses the mind and you do the thing that you've been putting off.

39:06Katie Miller:Would you rather know exactly what Bitcoin will be worth 10 years from today or know the true identity of Satoshi Nakamoto? Sasoshi Nakamoto. Yeah.

39:18I think the price of Bitcoin, I mean, I have a good sense of what it might be in 10 years. But I think, first of all, the idea of Bitcoin stands on its own regardless of who invented it. But there's been a good documentary that came out recently arguing that it's, you know, likely was Hal Finney and Len Sassman. I tend to buy into that theory, but nobody will know for sure, and that's fine.

39:43Katie Miller:What do you think of when the news got it wrong that they were like, it's this guy, he's living in Argentina. That got it wrong on me? No, wasn't this recently, and I'm not big into conspiracies, but they were like, we know exactly who he is and where he's living. Oh, on Satoshi Nakamoto. Yeah. I did briefly live in Argentina, that's what we were referring to. Was the steak good? Most of the, sorry. I said, was the steak good? Yeah, it was great. I mean, yeah, most of the things that have been published on the identity of Satoshi Nakamoto are totally wrong. I mean, we're clearly wrong. So yeah, that's not out of the norm, I suppose.

40:20Katie Miller:Would you rather be remembered for building Coinbase or for helping humans live longer? I think Coinbase is the thing I've been working on the longest and it's economic freedom, I would say is more like my life's mission. But I think that I can utilize some of the skills and proceeds from that to go. I'd like to help create lots of different innovative companies on the frontier of technology. And so I'd like to think that it's almost like Jeff Bezos kind of built his wealth at Amazon, but he's helping put that into lots of good things for the world. Or Elon with PayPal or something like that. I think those are good.

41:01models to emulate.

41:02Katie Miller:What's a conspiracy theory that you believe in? Well, there's some, I don't know if this is true or not, but I think it's really funny to think about whether Justin Trudeau is Fidel Castro's son. Like you have to admit that if you go look at the photos of his supposed father and Fidel Castro, it's like, it's pretty funny. It's so close. Yeah, it's pretty, so there's got to be some like DNA test or paternity test that could prove this. But I don't know. Yeah. So that's one that's just kind of funny. I think that's out there. But maybe I don't know if this is a conspiracy theory, but maybe like a contrarian view is that I think like the common view is that philanthropy is like this noble cause.

41:45And, you know, like Bill Gates, after the DOJ thing, he's like, I'm going to go rehabilitate my image and do philanthropy. I guess I have sort of a contrarian view, which is like a lot of charities and philanthropies are actually net negative on the world and they get captured. It's actually remarkably hard to find a foundation that has not gotten captured by ideology. And that's, I think a lot of people by trying to do something good, like maybe like criminal justice reform or something. And then it turns out they just increased crime by like letting a bunch of people, like all these kind of unintended consequences happen.

42:18So once in a while, you know, when you, when you have a company go public, you get all these financial advisors around you. and stuff like that. And they're often for like various tax reasons are like, okay, we should set up this foundation for you. And so far I've just been like, no, I'm not going to do that because my fear is that it just gets captured by some ideology that I lose control of it. Like if you look at like the Ford foundation, I think Henry Ford would be like turning over in his grave if he knew what they were up to. So I try to just, I have like a DAF, a donor advised fund, and I just try to put money toward things that I think are helping civilization advance.

42:56But I don't think I'll, I don't know, I don't want to say never, but I don't think at this moment I would ever create a foundation.

43:02Katie Miller:What's the craziest thing you've ever spent money on?

43:08There's this video game called Polytopia. Have you heard of it? Okay. It's pretty fun. It's kind of like the game Civilization. Yeah, but it's on mobile. Anyway, my wife and I kind of got into playing this game. And it has a pretty small following. I think only like 50 ,000 people like globally play it. But we decided at some point, a lot of the tournaments people were playing were like for like 25 euros or like different. So at some point I was like, maybe Maybe Coinbase should sponsor the Polytopia Championship that happens once a year. And we were kind of like fans of it. We were watching the top players and things like that.

43:54And the first year, I actually reached out to them and said, hey, do you want us to sponsor it? And they initially said, no, we're not doing any sponsors. It's very pure and we don't have any corporate influence or whatever. But then the next year, they came back like, actually, it would be nice to have some sponsors. So I think we might still be finalizing the details, but I think Coinbase is going to sponsor the Polytopia World Championship, and I'm pretty psyched about that.

44:14Katie Miller:It's a personal hobby. Yeah. What's the first app you open in the morning? Well, the danger, the temptation is always to look at the messages, whether that's on Slack or any other tool that we might use. And there's a temptation to go look at X, right? But I try actually not to do that because I think it can be a bad way to start the morning. And so try to listen to podcasts or audiobooks to kind of get my head right for the day, try to learn something, something that's educational or like positive or helps me think about how to build the world and build the future. What's something you're hilariously bad at?

44:57Well, okay, so something I'm hilariously bad at, I think that sometimes like reading social situations, because I think I think I'm somewhere on the autism spectrum where I'm not too far, obviously, but one of the gifts of autism is actually you're somewhat oblivious to social norms. This is part of the reason why a lot of entrepreneurs, I think, have a little bit of autism and they're willing to just go try things, which most people would be like, that's low status or it's weird, it's contrarian. And like, believe me, starting a crypto company like in 2012 was pretty weird. And like most of my friends were like, I don't get this.

45:43Why are you? This is weird. Why are you doing it? I didn't. It certainly was not high status or anything like that. So there's sometimes, you know, the positive aspect of it is I'm just willing to play with contrarian ideas in my head all the time and be like, oh, maybe we should try this. Maybe we should try that. Now, the downside of it is that sometimes like in a room, I could be completely oblivious where someone's like laughing at me and I'm like, I actually have no idea. I'm just going to talk, keep talking to them regardless. So it's a superpower and a weakness.

46:12Katie Miller:How would you explain Congress to somebody who's trying to get a bill passed?

46:19Well, by design, the founding fathers in all of their wisdom made sure that it was difficult to get a bill passed as it should be, right? I mean, if you wanted to make it simple and efficient, you'd have like a CEO kind of equivalent who is a single decision maker, but they created the balance of powers and the bicameral legislature and everything. And so you not only have to get a vote in the house, but also, you know, there's a hundred kings and queens so-called in the Senate. And so what does that mean? It's just complete like chaos and factions and collecting votes with, you know, different issues.

46:57But so it's so hard to get legislation passed, but that is by design.

47:00Katie Miller:What's the best part of trying to get a bill passed? I mean, there's just so many big personalities in D.C. It's kind of fun and awesome to just like there's crazy people, there's brilliant people like it's never boring. And I don't know, someone somebody told me one time there's like there's more actors in D.C. than in L.A. or But I think it's, I think like I've made some true, genuine relationships here that are just really fun and brilliant, like smart people. And then there's like some completely crazy people too. And kind of just have to roll with it. If you could host a dinner party with three people that are alive, who's sitting at the table, and what are you eating?

47:39I just recently, I was like reading more about like Claude Shannon and like Oppenheimer and John von Neumann and people. So these were just like brilliant engineers who worked on projects historically. I think that would be a fun dinner to get those folks together. That's just kind of, I think the Wright brothers are particularly interesting too. I've read their biography. You have to remember in the early 1900s or late 1800s, flight was considered kind of a joke by most serious people. They're like, man is never meant to fly. And like occasionally like these loony people would like jump off of a bridge with some like wings attached to their arms.

48:21They would always crash and everyone would laugh at them. And it's like it's really underappreciated. I think that these like two bicycle store owners with a very limited budget, like I think in modern I might get this wrong, but in modern day dollars, it was like they had maybe like a 10 or$20 ,000 budget from their personal savings. They didn't have any venture capital. They had competitors who were trying to build planes that were funded like 10 or 100x as much money. These two bicycle shop owners, just by tinkering in Kitty Hawk, you know, with their own inventions, managed to bring us into the aviation age.

48:58And then like the craziest thing about it is that you would have thought if somebody invented an airplane, everyone would be like, wow, that's super interesting. For years, they were going around like giving these demonstrations and nobody really cared. It was like shockingly, right? It's like the actually the military, the War Department or something at that time in the U.S. said, we believe there's no military application of the airplane. This was in like 1904 or something like that.

49:21Katie Miller:The Wright brothers landed their one of the planes on Fort Myers on Summerall Field here, North Carolina. Yeah. As like a demonstration. Yeah. And then, you know, arguably just 40 years later, it won it won World War Two for the Allies. right? So the airplane. So anyway, it's amazing to suspend disbelief and believe something. What if it was possible? Well, let's try it. That's incredibly important for people to do that. And then you have to be willing to be misunderstood and even vilified in certain cases when you first do something. And the full power of it won't be known for decades. Thank you so much for doing this.

49:58Thank you.

49:59Katie Miller:Thanks so much for watching this episode of the K. Miller podcast. Don't forget, We're live Tuesday nights, 6 p.m., everywhere you get your podcasts. See you next week.

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