AI, Chatbots, and the New Age of Men’s Health: The Future of the Exam Room

23 Dec 2025 · 48 min · 18 chapters

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In short

How AI and health informatics are changing men’s health care—especially the exam room, clinical documentation, the “scary in-basket” (patient messaging), and access to care—while emphasizing privacy, human oversight, and data quality.

Guests (backgrounds)

  • Dr. Denise Asafoje-Jay, board-certified urologist and assistant professor at the University of Chicago; director of men’s health and male reproductive medicine. Research in erectile dysfunction, male fertility, access to care, and AI/informatics. Trained at UCLA (andrology fellowship), Columbia (residency), Michigan (MD), Harvard Chan (MPH/health policy), Carnegie Mellon (BS).
  • Host: Dr. Jesse Mills (urology/men’s health clinician).
  • Producer: Jordan Runtop.

Key claims

  • AI-driven scribes can reduce physician documentation burden so clinicians can focus on patient connection; privacy consent and safeguards are essential.
  • Chatbots and EMR-embedded tools will improve triage and message prioritization, and may automate some low-risk tasks (e.g., refills), but not replace clinicians.
  • Informatics is the “science of information” across patient data and system/policy integration; success requires education, privacy reassurance, and interoperable data.

Notable examples

  • AI scribing during sensitive urology visits (e.g., erectile dysfunction) to avoid typing while summarizing the visit.
  • In-basket triage using keyword/symptom grouping to flag urgent messages.
  • Fertility: AI-assisted sperm detection/selection aims to speed up microscope searches in cases with no sperm in ejaculate, improving assisted reproduction workflows.

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

Tap a time to open that second in VO

Dr. Denise's Journey in Urology

0:04 to 1:26

Dr. Asafo-Jay shares her background and journey into urology and informatics.

“Are you looking for support in your weight management journey?”

Dr. Denise's Journey in Urology

2:34 to 3:07

Dr. Asafo-Jay shares her background and journey into urology and informatics.

“I'm inviting you to join the best-sounding book club you've ever heard with my podcast, Earsay, the Audible and iHeart Audiobook Club.”

Dr. Denise's Journey in Urology

6:12 to 8:31

Dr. Asafo-Jay shares her background and journey into urology and informatics.

“And I am so excited to be officially in the mailroom.”

The Role of AI in Patient Interaction

8:31 to 12:10

Discussion on how AI can improve patient interactions and documentation.

“But I think as I've now incorporated that into like my practice and even thinking about my own personal life, I think you think about how do we work smarter and not harder.”

Patient Trust and AI Acceptance

12:10 to 14:00

Exploration of patient trust regarding AI tools and their integration into healthcare.

“rather than paying attention to the patient.”

The Future of AI in Patient Care

14:00 to 21:48

Explore how AI is transforming patient care efficiency and accuracy.

“And also that's where we worry about, you know, medical errors.”

The Future of AI in Patient Care

21:49 to 23:11

Explore how AI is transforming patient care efficiency and accuracy.

“Are you looking for support in your weight management journey?”

Understanding Informatics in Healthcare

25:14 to 28:00

Delve into the role of informatics in improving healthcare systems.

“There's information and there's automatics.”

Optimizing Patient Access Through Technology

28:00 to 40:13

Learn how technology like chatbots can enhance patient access and streamline healthcare.

“Talk to me about some research, some things you're working on that people can look forward to?”

Optimizing Patient Access Through Technology

42:05 to 42:30

Learn how technology like chatbots can enhance patient access and streamline healthcare.

“Get up to 90 % cash back on eligible vet bills from less than a dollar a day.”
Show all 18 chapters

Optimizing Patient Access Through Technology

42:35 to 42:57

Learn how technology like chatbots can enhance patient access and streamline healthcare.

“$1 a day premium based on 2024 average new policyholder data for accident and illness plans, pets age 0 to 10.”

The Patient Journey: Anabolic Steroids and Fatherhood

42:57 to 45:56

Exploring the impact of anabolic steroids on men's fertility and recovery options.

“We do a segment on every show that is loosely titled, Am I Going to be OK?”

AI in Fertility Treatments: Sperm Selection Advances

45:57 to 49:35

Discussing AI technology's role in improving sperm selection and fertility outcomes.

“So just for like a two-minute sidebar, if there are any couples out there listening and struggling with fertility and a guy has very low to no sperm counts, we now spend hours under the microscope.”

The Future of Medical Decision-Making with AI

49:36 to 52:50

Examining how AI tools can enhance medical decision-making and patient education.

“When I saw one of those demoed and just how fast, you know, I think I'm fast.”

Personal Practices for a Grounded Life in Healthcare

52:51 to 56:00

Dr. Denise shares personal practices that help him stay grounded and effective in his role.

“Yeah, inertia is tough, especially for doctors.”

Wrap-Up and Future Plans

56:00 to 57:58

Dr. Denise discusses her upcoming projects and the importance of her work in fertility.

“What another cool little time to hang out and learn.”

Wrap-Up and Future Plans

59:18 to 1:00:56

Dr. Denise discusses her upcoming projects and the importance of her work in fertility.

“Mills and do not represent the official positions of UCLA or UCLA Health.”

Wrap-Up and Future Plans

1:01:03 to 1:02:19

Dr. Denise discusses her upcoming projects and the importance of her work in fertility.

“And now, another appliance triumph from your friends at Grand Appliance.”
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Transcript

Automatic transcript. May contain errors.

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4:12Welcome to the mailroom with Dr. Jesse Mills. Welcome back, everybody, to the mailroom. Dr. Jesse Mills, your host, joined again by Jordan Runtop, my producer extraordinaire. I'm super pumped, Jordan. You're going to meet one of my dear friends. I've known her for years and also one of the smartest rising stars in the world of urology, men's health, and actually a field that we're going to learn about today, informatics. and of course the two letters that everybody knows about and maybe doesn't quite understand and that is AI and their impacts on health. So it's going to be awesome. You'll probably know more about the tech than I do, Jordan, because you're younger than I am and actually have some tech background.

4:52So this will be fun for you and Dr. Denise Asafwa-Jay to have a convo. But let me introduce her because I'm super pumped for this episode. Super pumped for our listeners to hear a little bit about how technology is going to end up in your exam room. probably already has and is going to get even more interesting and exciting. Dr. Denise Safwa-Jay is a board-certified urologist. She's a researcher of urology, men's health, and a health policy champion. It's a lot. She does more than I think most people do their entire careers in a week. She's an assistant professor of urology at the University of Chicago and serving currently as a director of men's health and male reproductive medicine.

5:29Her research interests include erectile dysfunction, male fertility, access to care especially in that field, AI and informatics. She completed her andrology fellowship training at UCLA out here in Los Angeles, did a residency at Columbia University, a medical degree from Michigan, master's of public health and health policy at Harvard T.H. Chan School of Public Health, bachelor's from Carnegie Mellon, and is a proud member of the storied and legendary sorority Alpha Kappa Alpha, another celebrity to join the likes of Maya Angelou and of course Kamala Harris. And I am so excited to have you on the show.

6:07Dr. Denise Asafoje, as she goes by Dr. Denise. Welcome. I can't tell you, I'm just getting chills seeing you again. How have you been? I am doing great. And I am so excited to be officially in the mailroom. We have known each other for many years. And you have definitely inspired me and many others to really be active in this space and think bigger outside of our patient interaction. So I just thank you for that continued inspiration. But I'm so excited to be here. Well, I thank you for making me smarter. You know, for a guy like me that, as you know, I'm about 50 percent of the time able to do a screen grab on my iPhone and the other 50 percent of the time I just turn it off and it goes to a blank screen.

6:44And yet, you know, tech is like you laugh, Jordan, but it's true. I mean, it is I am like I'm like a 55 year old guy trapped in an 85 year old person's reality. And in fact, my dad is probably more tech savvy than I am in his 80s. So so I own it. And thankfully, I have a lot of people around that can help me. and Dr. Denise, you're going to help our audience really understand this. So, so talk to me about your journey a little bit, because nobody just, you know, when you're 12 or 15, say, I want to grow up and be a medical informaticist. And most people can pronounce it. And you trained in microsurgery.

7:21So you still have a busy surgical practice. You're still a busy urologic practice. You still take care of lots of guys in Chicago and, and points well beyond. So talk to me, Jay, about, you know, what's your day to day and be, how did you get into this? I assume it's something to do with your science background at Carnegie Mellon and beyond. But yeah, talk to me. Let's talk about it. I think, you know, from the perils of CMU and any person who's gone to Carnegie Mellon actually has to take coding. And so I think very early on, I do feel like I had some inclination or, you know, some easy adaptability around that.

7:56But I think, as you know, our field is already very tech forward. If you look at most of these surgical subspecialties, urology is always recognized as being very technology forward. We do robotic surgeries. We've been ahead of the curve, even with microsurgeries, as male infertility specialists we're doing. And so I think the technology piece is always around us. I think as you're doing these things day to day and you're interacting with patients, I think I am constantly having this internal conversation of how can we make this better and easier? You know, AI has been surrounding us for years.

8:29Now it's really penetrated healthcare. But I think as I've now incorporated that into like my practice and even thinking about my own personal life, I think you think about how do we work smarter and not harder. That's certainly a principle we've always learned at, you know, UCLA under you. And it's, you think about how you can leverage some of these technologies. And so I think as I was continuing to work, continuing to build my practice and having this, you know, societal penetration of AI, it was just like, well, we can kind of figure out how we can make it work for us as physicians, right?

9:03Minimizing the brain drain, minimizing fatigue, and thinking about, well, how can I really be in tune with my patients? And how can I leverage these technologies to actually make our day to day easier? Yeah, so walk me through that, because, you know, I go into a room, and I don't bring my phones in the room, I don't use the computer. and I, you know, I love it. I love that patient interaction. And thankfully, you know, I still have a real human scribe and she's terrific. And so maybe that is part of it. But walk me through the patient interface. How is that now? And actually just, you know, tell me what you're doing in your own clinical practice, how you use that in the room with a patient and what are their expectations and, you know, what should they be worried about or what should they be excited about?

9:47Because right now it sounds like it's a lot of like, Like, how can I make, you know, documentation is what kills a doctor. We know it burns us out. You know, every patient note we have to do what some ridiculous amount of 75 clicks or something to close a note. So yeah, kind of give me some highlights about what excites you, what you're using now. And, you know, let's let's let that rip for a while. Yeah. So I think just as you mentioned, everyone thinks about, you know, documentation taking so much time. So I think when you go into the patient room, we're thinking about we want to be one with the patient.

10:20We want to be engaged. We don't want to be thinking about the 75 clicks that we need to finish their note. A lot of places, my institution included, are now incorporating these AI-driven scribes. So this really allows you to talk to the patient, summarize that conversation, and at least get you 90 % of the way there for that documentation. So I think the important thing for physicians is that this really helps us to unload the cognitive brain drain of all the things we are trying to manage in one patient interaction. Like we could just talk to the patient, right, and just know that everything we want to capture is actually being captured.

10:57I think for the patients, they really appreciate this because instead of them watching me type as I'm talking to them, I can actually have a conversation. You know, a lot of the demands of healthcare as it's gotten busier just makes the time shorter with patients and it really has diluted to an extent our interactions. So I think that when someone goes into a room and they're talking to you, that human connection, that communication with your doctor is so key in engaging you with your health care, you know, actually having you engaged in your, you know, your own long-term health. And so I think that that has really revolutionized our ability to just connect with patients.

11:36Now, on the patient side, and I think things that institutions are still working through, it's the privacy piece, right? because everyone now is just thinking about, well, if I talk to you, is this conversation going to end up on like the dark web somewhere? So we are still trying to keep up with privacy laws. We're still trying to make sure that people are appropriately consented to utilize it. But I think there's no way around the fact that this has made our lives much easier just by unloading this task of over-documentation and paying attention to that rather than paying attention to the patient.

12:11So what's been the buy-in so far with your patients? I mean, I imagine if you can increase efficiency and you say, okay, I can see 15 people this morning if they all do AI scribe. But I imagine if to consent somebody and say, hey, is it okay, Jim, if I turn on my AI scribe? And if they say yes, cool. But if they refuse, then all of a sudden your 15 patients feels like 50. So walk me through how the buy-in has been with patients and what that feedback has been like for you. Yeah. So I think the buy-in has been largely positive with patients. You know, in our subspecialty, I think it took some time only because we're discussing really sensitive topics, right?

12:53Like most guys, if we're talking about erectile dysfunction, they're like, I really don't want this conversation anywhere on the dark web. And so I think that when your patients trust you, and I think when you frame it as such like, hey, I'm actually really more interested in hearing your story and engaging with you during this interaction, I don't want to have to worry about typing. I think that most people now, because they also have AI penetrated in different parts of their lives, it's not like a new concept that you're introducing to them just in their visit. But I do emphasize that, you know, there are privacy checks in place.

13:28This is, you know, just internal. This will not end up on the dark web. And so I think that's been reasonable. But I do think that our specialty uniquely because of what we discuss, I can see that that hurdle in terms of kind of trusting things may be a little higher than others. So you got the documentation part down. Somebody, you have a perfectly templated note. Somebody comes into you, say he's 44, he has low testosterone. You get the whole story. You've come up with a treatment plan. What else can it do? I mean, can you say, Alexa, order me a CT scan or Alexa, can I get a CBC, you know, blood work and tell me like, because the ordering also is very onerous.

14:09And also that's where we worry about, you know, medical errors. If you ask Alexa to ask a guy for an acid blocker and instead you end up, you know, with an alpha blocker or something, then, you know, there could be medical errors that have to be oversight. So what are the firewalls there? What are the ways that we protect ourselves other than having to go through and hand edit every node in order set anyway? Right, right. So I would say that most of the AI scribe systems are not quite to the point where they're doing automated ordering. For the most part, I think it really has been optimizing the documentation piece.

14:43That's coming down the pipeline because a lot of the health systems are still dominated. as you know, Epic is like, you know, dominates most of these electronic health systems. And I know they're actively working to also keep up with technologies that are really outpacing what these systems inherently do. But I think we are getting there. We are getting there so that literally when by the time you finish talking to a patient, your order should be done ideally. And that's what we're working to. Orders will be done, your note will be done. And then you can start with your next patient in peace. And so I think the efficiency has really, I mean, even within the next year, I think we are drastically going to see changes in how physicians are able to engage with their patients in this way.

15:23And it's just going to make our lives easier. And quite frankly, the patient's lives better as well, because I think they're going to see a more engaged doctor. They're going to see a doctor that can really go through this interaction with them without the worries and pressures of what do I need to get done before we time out. Right. Yeah. And if the information going in is good, I mean, that's, of course, the entire problem with AI is that, you know, garbage in, garbage out. But if the notes are good, then they can be easily traced. And so you're not having to pour through thousands of pages of medical records.

15:54Say if I send you a patient from Los Angeles and you're taking care of him in Chicago, you don't have to go through either my handwriting, which you know is infantile, or you have to go through my documented notes with terrible spelling or anything else. Although actually that's one thing I'm okay at. But again, I mean, if you had something more concise and bullet points, okay, here's what Dr. Mills did in Los Angeles. Now he's in Chicago. I can take over the care. Is that sort of a reasonable thing for a patient to expect that you're like, oh, well, Dr. Denise, you saw Mills' notes. Here's the game plan.

16:29And that's an easier implementation? Yes, I would agree with that. I think it's also important for people to remember there are still people a part of this process, right? So I think even though you may see, hey, we're using like an AI scribe, it's not as if it's totally hands off and I'm not looking at it or double checking, like there is still some aspects of it that I can kind of override, like we can still override that. So I think we're still important parts of the process, but I also encourage people to press your systems about these questions, right? So if I talk to you and I give the disclaimer about this and you're still like, well, tell me more about that, and maybe that visit, maybe we just do it the old fashioned way, right?

17:09And so you're comfortable, but I do think that the expectation is still, accuracy with our notes, still us being able to tease through what our colleagues are recommending and being able to continue with care. But I do think that as people learn more about this, the biggest thing I see is really concerns around that, you know, privacy and like data aspect, but medical systems take this very, very seriously. And so we're doing the same. Right. And especially, I think as you said, you know, I imagine the world of psychiatry, also incredibly highly sensitive notes the world of urology very sensitive subject matter so it's not like you know you get your sore throat diagnosis thrown out on the dark web but something a lot a lot more concerning especially you know with a lot of high profile people that we see in both of our practices it becomes even more of a concern so your patient experience you you're done with your office visit talk to us about because one of the other things that kills physicians of course, is the in-basket and the patient notes.

18:10And then walk me through, you know, what the world of medical chatbots looks like now that, hey, if you want to send a message, because a lot of the telehealth, if you're going to go through a telehealth company to get your testosterone or your erectile dysfunction, usually it's just, you know, cute little chatbot. I've heard I'm asking for a friend. I just want to be sure everybody knows. But, you know, so I understand there's a little guy there that says, Hey, Jesse, I mean, Hey, John, here's this, here's this, you know, hope you're doing great on your, on your pills. Do you need a refill or, Oh, you're having a headache, do this, do that.

18:43So, so where are we with medical chatbots and helping the doctor with the in basket so that patients feel like they have access to care, but we're not in front of our laptops at 11 o 'clock at night. Yes. The scary in basket as, as I like to say. So I think that's also a really exciting space. So, you know, you send your doctor a message and, you know, now your doctor, maybe likely a team of nurses and other people are also kind of helping to, you know, triage and get these messages going. Largely now, because with AI, we can tap into certain keywords that these systems are recognizing. These chatbots are also being designed to pick up and group symptoms, right?

19:20So if someone messages you and they have a series of symptoms, it can actually now, and people are doing this now, even in their, you know, live patient interactions, kind of summarize and pare down like what could be going on. I would say at least for the system that we're using now in my institution, it's not automating that for us quite yet. But as I keep up with what these telehealth companies are eventually trying to do, that's what it is. So when someone sends a messages, at least they can put to the top of your in-basket, this person's message sounds a little bit more concerning than the other person that maybe just says they, you know, need a refill for Robitussin or something, right?

19:56And so I think it's going to help us to tease through these hefty in-baskets to at least better triage. Because as you know, depending on who's working with you, they may be able to do that, but we really want to be able to target what the most important things are. I think similarly, when you're going through these kind of task-oriented things like refills, those are easy things to build in. Someone sends a message in, with the exception of testosterone, since it's controlled, a lot of things can be, you know, automated. And so I think that is really kind of the lowest hanging fruit where some of the companies are now in terms of just an easy way to have a pathway just to refill easily, like safer medications.

20:37But we are also getting to the point where these bots are also going to be doing the back and forth, you know, with our patients until it's something where maybe like a human may have to intervene. So really exciting space. But I would say now it's still very much me and probably you and the rest of our team, but we are getting to a point where we are further. Because I think as we talk about this technology piece, most of these systems have been set up to automate the wrong things, right? Everyone wants to just automate billing. Everyone wants to automate documentation. And we are really trying to think about how do we ease our cognitive load, right?

21:15And so if some 10 people are messaging us about the same thing, we have to see, be able to, you know, sift through that and not add onto it the technicalities of billing, documentation. And so I think that's where, you know, things like informatics, things like AI come in because we need to actually optimize systems that work better for us.

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Read the full transcript

25:26What is informatics? I mean, just back up that a little. It sounds like a made-up word. There's information and there's automatics. Infographics. Yes. Infotainment. Exactly right. Yeah, exactly. So edutainment. I think that's what this is, is edutainment. Yes, edutainment. Edutain is, Dr. Denise. Edutain is about informatics. I, I, I, is that sort of the entire field or is that, you know, walk me through what, what, I mean, again, that's where I get to like, what do you, what are you thinking about? You know, when you're not taking care of patients and when you're not operating on guys and you're not doing everything else that you're doing, what are you thinking about?

26:09You know, what are you working on in this space that you're going to define for me here? Yeah. Well, you know me, I'm thinking about just changing the world and, you know. Always for the better. Always for the better and how we can leverage systems already in place to do that. Informatics is just how it sounds. It's like the science of information. So it's a science around storing, obtaining information, sorting information. And when you think about it in a health system setting, it's thinking about all this data that we are taking in. And it's not just patient level information, right? It's looking at like policies that govern these systems that we work in.

26:46It's the policies that govern what hospitals are able to do. So there's a lot of different levels of information that we are constantly storing and organizing. But I think what most people think about first is, oh, it's all patient information. There's so much information coming into us on a patient level, but on a system level. And the beauty of informatics is thinking about how are we integrating these systems to actually work better together. So when you think about information systems for, let's say, patient information, that still has to talk to another system that's also giving the health system information.

27:25Nowadays, and really for as long as informatics has really been a field, this also requires interdisciplinary work, right? So when you think about information, every hospital will have their IT team. And I think most people think informatics people are just like information technology, but that's actually just one aspect of it, right? in terms of how we are organizing, storing, and staying within policy. But it's literally the science of information. But in the health system, it's how we are leveraging these different information systems to actually keep the machine going. Does that make sense?

27:59It makes perfect sense. Yeah. So then how do you harness that? How are you going to change the world? Talk to me about some research, some things you're working on that people can look forward to? Because I guess what I want to know is, you know, it's such a rapidly evolving field. Where do you see your practice, not your practice, I guess, a practice of medicine, because you're obviously at the forefront, you know, two years from now and five years from now in terms of the patient experience and, you know, what's your role in that? Yeah. So I think even thinking on first, like the health system level, right, I still think back to access, like we don't do globally good enough of a job of figuring out like the optimal ways for people to still engage and get into the health system.

28:42And now with so many more people needing to get into the health system, we just have to make that more efficient. So whether it's the chatbot that can help someone triage, even what doctor to go and see, right? Like how oftentimes do people just get to us and it's like, I'm meant to see a neurologist or, you know, or just all of these things. And so even just helping people to figure out where to go. And then once they are in the system. I don't know about you, but even when I have a basic medical issue, I literally think about like, I'm a whole physician and it still is so much work to, you know, the teams I have to work with, the follow-ups, the phone calls.

29:19How can we make parts of the, even making an appointment easier for a patient, the right appointment, the right doctor, the right time. And so I think because I care about access, as I know you do, I'm constantly thinking about why aren't these systems optimized to just make it easier for people. And when we get information like patient experience polls and things like that, what are we actually, how are we tapping into that data to actually then pour into enhancing, you know, the experience. So I think on a hospital level, I really envision continuing to work in that space where we can optimize access.

29:54And even though I'm starting in the lens of urology, I think globally, there's a lot of issues with just getting patients to the right people at the right time. And we now have the ability, the capability of empowering patients to utilize these systems to actually, you know, get there. So is that an app? I mean, so the deliverable would be somebody that has maybe less access to care, maybe on public health insurance, that's somewhere in, you know, a lower socioeconomic part of Los Angeles or Chicago has an app on their phone where they say, I have a sore throat, or they click. And then not only do they get, okay, well, you know, do you have a fever?

30:35Do you get the chatbot starting? At the end of that, there's like, hey, there's a doctor, you know, two blocks away that has a 615 appointment. I mean, is that kind of the holy grail of, because even in my busy practice, where we have a wait list of sometimes months to at least eight months sometimes to see me, I still have pockets in the day, you know, where I'm telling jokes and boring my staff with my stories, right? That, that if somebody was walking two blocks away and said, huh, gosh, it sure'd be nice if I could get my erectile dysfunction taken care of and all of a sudden, you know, snap.

31:10Is that, is that a reasonable thing that could happen in the next couple of years? Absolutely. And you hit it right on the head. You know, I think we're thinking about the system of efficiency. How oftentimes do we have blocks of time that are like, you know, underutilized. And, you know, we could actually be getting that patient who otherwise is waiting eight months, but even better. So the patient who actually should be seeing you is getting to you, you know, at the right time. And so I think now, and this is actually a place where our system is working toward, but now there are even embedded chatbots within the EMR.

31:42And where we're trying to get to is that patients can actually have these conversations in the EMR to accelerate systems like, okay, I can make my appointment and I can find this specific person. We are already there. And it's funny, it's a catch-22 because like you said, we sometimes do like having maybe an extra 15 minutes there where we can have a breather. So I think some of the adoption issues, even with our own colleagues, is around, well, is now this system going to make sure every minute of my day on the clock is accounted for as a hospital head. Like, yes, that's what they want, right?

32:18They want to make sure that you are being used as efficiently as possible. But then does that contribute to burnout? If now these pockets that we've been used to leveraging to build in our own rest are now being tapped into to do even more work. And so it's still this push pull I find within the system, but on the patient side, it is actually going to really enhance patient care and access. Okay, so I told you this years ago when we met that I have a feeling that you're going to be my boss someday. You're already on more advisory boards and more national boards than I am in my career from the AUA through SMS and ASRM.

32:56So someday you're going to be, I'm going to make up your job title, say seven, eight, ten years from now, you're going to be chief informaticist for HHS. So what is your blueprint? Like how do we get from where we are now? What structural changes do we need? Where do we need to spend the money to save money? Because a lot of what you're saying is if we do this more efficiently, you know, just like we say in the OR that time is money, because every minute in an operating room in the United States is somewhere around 300 to$400 a minute. So if we can figure out how to turn a room over faster, we can see more people take care of more people and become efficient.

33:30And I feel like there's so much, I hate to say the terms these days, waste, fraud and abuse, but at least waste and abuse in the health system that we could get better, right? And so what do you need when I nominate you for chief informaticist of HHS? Tell me what that looks like. Well, that's so kind of you, Dr. Mills. I think that, you know, the first thing really simply enough is actually education. You know, I think even though there's all these awesome systems and things in place even now that we could leverage even more, the fact is most people still do not trust the system. And I think that when, and this is not even just physicians, even just patients, right?

34:08And so I still think there's a lot of education that needs to happen. Interestingly, even though a lot of people now are using like, you know, AI in their daily lives, right, to come to my office and give me their own diagnosis and other things, when you then contextualize it around like their, you know, like healthcare, like you using it, it takes on a different tone. You know, now with medical legal issues around like, was that really like your, you know, diagnosis and synthesis or was that an AI chatbots? Like those are things that are getting tricky. But I think the first part of this foundation is I think widespread education and reassurance around privacy.

34:45We are still not where most other parts of the world are around just protecting people's privacy and data. If you go to Europe right now, Europe, China, they've been ahead of the curve when it comes to setting up these privacy practices in place. And I would say our government now is actually, I'd say, quite supportive of AI. You know, I think that this kind of ebbs and flows for people, but I do think that people just need education reassurance. And I think after that, we also have to think about just organizing our data, right? So back to informatics, we have a lot of information out there. But how useful is it if we can't actually tap into it and do anything with it?

35:23And I think this is where health systems and these entities have to talk to each other, because right now, the way I'm collecting information may be different than the way you're collecting information. and we can't actually figure out patterns and other ways to tap into it if we're collecting it differently. So I think the next step is that level of, that high level of cooperation just around the way we are doing things, our processes and our data collection, because if we don't study that, we actually can't make things better. So I would say education and then that cooperation really is not where we want to be.

35:56And I think that's going to be key if we're really going to change the world, as I say. I love it. I love it. Yeah, actually, you brought up another point that one of the frustrating things for a consultant such as us, you know, we're not primary care, we're specialists is that say you get an ER note, somebody is in the emergency room, the emergency room notes at 12 pages long, right? And they talk about every vital sign that since they come in. And to get to the salient information, I'm using my non AI brain to go line by line, and I'm a fast reader, and I can process pretty quickly. but is there software now that can look at an ER note or look at a long note, get rid of all of the stuff that, you know, they have to document so that we know exactly.

36:41I mean, talk to me about that. Cause yeah, our medical records now are just, you know, if they were pages, they would be trees worth of information that would be plopped on our desk. Every time somebody gets out of the ER. Exactly. And cut the fat as we say, no, totally agree. You know, our notes probably a fourth of what those other ones are. Yeah. Yes, there is software. A lot of several health systems, maybe not a lot, but several health systems now have their own kind of internal AI systems so that you're not using a public one that could potentially put patient data out there. We're using like Phoenix AI, for example, but you can actually then summarize it.

37:21Now, unfortunately, now it's that extra step where you may have to just upload that document to get those salient points. But I think certainly in the next few years, we are going to get to that point where we're going to have a chatbot in our EMR to just say, summarize this, or, you know, let's pare it down to those salient points because this just contributes to our fatigue and then just a cognitive decline that we face as, you know, physicians, because we're spending time doing things that we don't need to be doing. We need to be thinking about, you know, patients and really optimizing their care, not sifting through someone else's nose.

37:56So I just think, unfortunately, the way that EMRs have been set up, it's again, it hasn't put us first. And I think more of these systems are really thinking about that a little bit better. So yes, I think that's also something coming down the pipeline, but you can do this like manually now for yourself, as long as it's a HIPAA, you know, kind of protected system to summarize that. Okay, well, you're getting me excited. I I think I can get beyond learning how to take screenshots. We can get you there. I'm positive. I'm positive. You'll be getting a lot of texts from me saying, Dr. Denise, I'm stuck in some dark web.

38:34I don't know what happened.

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42:57We do a segment on every show that is loosely titled, Am I Going to be OK? And it's always about a patient journey, you know, sort of like, you know, a guy you and I see all the time in our clinic. He's on anabolic steroids. He wants to be a dad. Is he going to be OK? Is there a way to treat that guy so that he's going to recover sperm? And, you know, you hear the story and, of course, you say, well, yeah, he's probably going to be OK. We can do this. But for this episode, because we're really focusing on informatics and AI, I want to ask about our physician colleagues in a couple of different fields, because we hear things about machine learning that can either help or replace radiology, pathology, dermatology.

43:40So walk through some of those advances and are colleagues going to be okay? Are there still going to be radiologists in five years, 10 years and see what, you know, see how those guys are doing? Yeah. Well, I think short answer is absolutely. You know, all of the systems that we train, you know, in the space of the AI machine learning is still reliant on that human aspect of helping with the training. I think what we have done, which has been smart, has been using policy to continue to protect our specialists. So, for example, if you are a radiologist and they all very openly use these systems to kind of sift through all of the images that they get.

44:20But you can't bill for it unless, you know, there's like a human part of that. So I think at least here in the United States, there has been systems in place. And this is where specialty societies have been key and, you know, protecting themselves. But I think this is where you leverage policy, right? And this is where you partner. And I think as we've seen in radiology and pathology, they have been early leaders actually in the AI and informatics space just by virtue of what they do. It's kind of these fields that lend themselves better to lots of information to then train and do all these things.

44:55But I think they protected themselves around billing. I think they've also recognized that this thorough put of information, they can actually do more, but I think they're still in the driver's seat. So dermatology path, you know, we get these, you know, you get all these articles now, are they going to be surgeons? I'm like, we're always going to be here. I think people just have to recognize that we are still steering the shift when it comes to training. The fine-tuning is going to be what do we still need to be in the driver's seat for, right? And I think this is where the better we get at good data and good information in and getting in good information out, we still have to make sure we have those checkpoints in place with humans behind that.

45:40And I don't think that's ever going to go away. Yeah. I mean, I'm super excited in our field. But I guess we can talk a little bit about what are the advances in the men's health field. And one thing that I came across recently that I'm sort of blown away by is the sperm selection and sorting technique in either using ejaculated sperm or testicular sperm extraction techniques for in vitro fertilization. So just for like a two-minute sidebar, if there are any couples out there listening and struggling with fertility and a guy has very low to no sperm counts, we now spend hours under the microscope.

46:16I mean, I'll give you an example from just yesterday where I was performing a surgery on a man that has no sperm in the ejaculate. And the surgeries, you know, Dr. Denise, takes sometimes two hours, sometimes four hours of looking in the testicle for all these little pockets where we might find sperm. And then it takes hours upon hours. In fact, our embryologist worked for about three hours yesterday and three hours this morning. And they found one sperm, one modal sperm in all of that. Right? I know. So, wow. I mean, you know how that is. It's just, you know, you just never give up until you find it.

46:50But now I'm understanding that there are not only embryologists who are trained to look under a microscope through slides after slides of tissue that can take hours. But there's some sort of oversight with machine learning where there's software, there are companies coming in that they can look through that a lot faster and have maybe even improved accuracy. Have you worked or seen any of this technique and technologies coming down your way? Because I know that there's, I mean, your old alma mater, Columbia, I know has looked into this and has actually implemented AI in assisted reproduction. So give us something to look forward to there for our couples that are struggling with fertility out there.

47:31Absolutely. And I think this is one of the most exciting aspects when we really personalize it to our field. You know, as you mentioned, for those couples where maybe you don't have, you know, sperm in your jaculate and you're doing more of the sperm sample. But I think in these cases, this is really where I think we're going to see these game changers, because the more information, again, getting back to data, right? And this is why data sharing is so important. But these systems are being trained to recognize, even down to like a pixel level, you know, what are the patterns around where we're finding things like sperm cells that are moving as we try to still better define those cases where we spend hours and hours.

48:10But we're going to get to a point where we're slowly getting there to a point where it can actually capture what part of your sample actually has like the sperm, you know, that you need. And so I think that that is something that is already here. It's also stemming to radiology as well. And so when you look at images, even though we don't really, for most of what we do, like require a lot of, you know, like ultrasound and things, but people are actually also using like ultrasound to figure out patterns around people that may actually have like viable sperm, which is like crazy. really getting down to, again, defining that pixel to the way, you know, so I mean, people are already doing this.

48:48But I think in short, you know, this is, and again, to emphasize, this is why we all have to talk to each other, we all have to use, you know, leverage our data with the research. Because if we're not sharing this information, we need enough of these samples to then figure out what part of the sample actually has a sperm and to be able to replicate that with other patients. And so I think, yeah, our REI colleagues already doing this for assisted reproduction, they're already using this to select out the best embryos and other things. But I think for sperm samples, this is already here. And I think this is going to revolutionize couples that previously we may not have been able to find sperm, but doing it in a high level, more efficient way, just because of all the training that these systems have had to really hone in on those samples.

49:35Yeah, no, it's truly spectacular. When I saw one of those demoed and just how fast, you know, I think I'm fast. You've seen me work under a microscope. And I think when I saw what this computer was doing on just a normal slide and how quickly these little halos were appearing every, you know, little sperm here, little sperm here. I mean, it was just like, not even, I can't remember what he was saying. It's like a hundredth of a second it takes to recognize sperm. And when you're doing that over grams and grams of tissue in a large microtessia, just it'll accelerate as well as you know hope improve the accuracy but as you said you still need some person there at the end of the day to to kind of go to the next step and and use that sperm so so it sounds like you and i are going to be okay there you can't you can't do a vasectomy from home and you can't uh you can't put a penile prosthesis in from home and so not yet not yet well that's it so i'm heading off to the the ces consumer electronics show in vegas in a couple of weeks, what should I be looking out for there?

50:33What is, what do you know about what's in the pipeline that, that is exciting you, you know, for the next couple of years? Yeah. So I think, when we think about medical decision-making and how that's really going to aid providers overall, I mean, I think not so much for physicians, but quite honestly, our system, you know, now we have different levels, our PAs and MPs. And I think because of the different levels of training, I do think that some of these medical decision tools are going to actually be quite helpful, especially if you think about places, rural areas, underserved areas that may not have super specialists.

51:08I think that these chatbots and I think that these aids that are AI driven are really going to help people who are in places that don't have access to UChicago, UCLA, and some of these other big places. Paring down even to our surgical field, I think when we think about kind of surgery across the way, right? And so far, robotics has really been a space where they've been able to train and kind of do surgeries from afar. I think it's going to be really exciting for us to do the same with, you know, our microsurgeries and getting to a point where we can also assist people that are not in our, you know, domain necessarily, our geographical area in some of these cases around the world.

51:49You know, I mean, fertility is alive and present throughout the world, but not everyone has the technologies that we may have and other places may have. So I think what I would look for are certainly what's coming down the pipeline with medical decision making, patient education, which we haven't really talked about. You know, I know something I've picked up from you, I have like handouts and summaries for everything. But nowadays, you can really fine tune and personalize patient education, you know, pamphlets, handouts, you know, for individuals. And so I think that aspect is inciting where maybe someone is not just getting your generic, you know, everything to know about like Cialis or something, but they're getting something that's pivoting from the visit you had with them and really giving them what they need and really kind of that, you know, aspect of precision medicine.

52:35I think those are kind of in short, the low hanging fruit of what's out there. Everyone is going to just be trying to find ways to make our lives a little easier and lure us in, but physician buy-in with this stuff is not easy. So if it's not things that make our lives easier, I think it's going to be, you know, a hard sell. Yeah, inertia is tough, especially for doctors. We're kind of stubborn and conservative, and we find one way to do it, and it's hard for us to change. And so that's why we need people like you. I used to call you a rising star. Now you just are a star in urology and health policy.

53:10There's another part of this segment that I always like to ask my guests, especially somebody that is a men's health specialist and therefore a health specialist, is that what do you do, Dr. Denise, every day to make you? What grounds you? What is your thing where you wake up and say, I have to do this to make sure I have a good day, to make sure I can be the best me and take care of the hundreds of guys that are relying on you every week? Yeah, great question. And I think this is also something that as we take care of more people, we have to be consistent with this to ground us. for anyone that knows me, honestly, I think kind of my spiritual base has always been a really important part of me.

53:50I pray every day. You know, I wake up and, you know, I listen to whether it's kind of, you know, just some music that kind of calms me. But I just really pray about the day ahead. You know, I pray that I come home. I pray that it just goes well. And I think that's something that my whole life has really, you know, been able to ground me and just kind of see the bigger picture, you know, what I do. I think outside of that, the physical piece that also connects to your mental and spiritual, I have to stay active. It's so hard to, you know, be still and want to be still when you have so much to do.

54:28But I'm like, you have to get your blood flow going, you got to get those endorphins going. And so that's something that I still keep as an important aspect of my life. Could be better with sleep as we maybe all could be. But I listen to the podcast. We just had a sleep specialist on. So you have to learn from Dr. Kishani. Oh, yeah, I've been working on that for a long time. But I do think that that is one thing that every day, I just wake up with some quiet time. And I think that bridges well to kind of the rest of my day. Yeah, I think this may be the first time in our history and friendship where I've actually seen you sit down.

55:06I'm trying to remember. I don't think I ever have ever seen you sit. Whenever we're at a meeting or conference, you're literally running across the room. You always have time for me, which I'm grateful for. But by the same token, you have three other meetings you're getting to at warp speed. Somehow in the nicest Chanel shoes possible, you still manage to walk a straight, almost a run line to get to where you go because you are always the best dressed person at any conference that I see on top of it all. So it's - I was just trying to keep up with you, you know, you're talking well, just keeping it going.

55:39I can't get into those Chanel shoes as well. But I'm going to try. Those are 26 goals. Dr. Denise Asafwajay, my dear friend, a true just hero to healthcare and guys everywhere. It's just so awesome you spent some time with us and you delivered on the mailroom. with Dr. Jesse Mills. You delivered. Thanks so much, Jordan. What another cool little time to hang out and learn. I am full of hope for the future and for my medical practice. Yeah, well, our part two will be hopefully me coming to tell you more about how we're going to help people find better sperm and egg donors. That will be a part two of what we're doing.

56:25I think that it's, and being in the data space, of course, as if I don't have a million things to do, I've also have actively thought about ways to solve some of the issues on the fertility side. So I'm really looking forward to that. And if I'll drop a shameless plug for people as they continue to follow me, but this will be rolling out soon. My platform just helping people to find egg and sperm donors a little easier and leveraging data. It's not a shameless plug at all. That's a public service. How do people find you? How do we, and we'll put these in the show notes too, obviously, but how do people find the brilliant mind of Dr.

57:03Denise's self-worth? Well, on Instagram, which is, I think, where most of my patients do find me, I'm Dr. Denise Official. That's my official tag. On Twitter, I'm Dr. Denise underscore, and I also have a website, DrDeniseOfficial.com. So usually on my Instagram, patient information there, and I think as I'm getting more things out here with this other platform. You'll see more information there, but I'm happy to connect. And certainly anyone who is in Chicago who needs anything for male infertility to sexual health needs, I'm your gal. Oh man, we knew you when we got you before your star, just supernova.

57:43Thank God. Thanks so much, Dr. Denise. I hope you have a wonderful rest of your day and I appreciate you coming on the mail room with me and Jordan. Have a great time. I can't wait to see you in D.C., if not sooner. Yes. Thank you so much. It was such an honor being here. An absolute honor. So happy. So excited. Follow the podcast. Follow the podcast. If you're listening, you should be. Bam. Look at you. Dr. Denise.

58:23Let's talk about it. Let's talk about it in the mailroom. Let's talk about it. Let's talk about it in the mailroom. The Mailroom with Dr. Jesse Mills was a production of iHeartRadio. It was executive produced by Jordan Runtog. It was edited, mixed, and mastered by Bahid Frazier. And the theme was provided by Long Transit. If you liked what you heard, please subscribe and leave a review. For more podcasts from iHeartRadio, check out the iHeartRadio app, Apple Podcasts, or wherever you listen to your favorite shows. This program is intended for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.

59:13Consult your health care provider for any medical or other related questions or concerns. The views and discussions aired on this podcast are those of Dr. Mills and do not represent the official positions of UCLA or UCLA Health.

59:47or some adults with overweight who also have weight-related medical problems to lose excess body weight and keep the weight off. ZepBound is approved as a 2.5, 5, 7.5, 10, 12.5, or 15 milligram injection. ZepBound contains terzepatide and should not be used with other terzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if ZepBound is safe and effective for use in children. Don't share needles or pens or reuse needles. Don't take if allergic to it, or if you or someone in your family had medullary thyroid cancer, or if you've had multiple endocrine neoplasia syndrome type 2.

1:00:24Tell your doctor if you get a lump or swelling in your neck. Stop ZepBound and call your doctor if you have severe stomach pain or a serious allergic reaction. Severe side effects may include inflamed pancreas or gallbladder problems. Tell your doctor if you experience vision changes before scheduled procedures with anesthesia. If you're nursing, pregnant, plan to be, or taking birth control pills. Taking ZepBound with a sulfonylurea or insulin may cause low blood sugar. Side effects include nausea, diarrhea, and vomiting, which can cause dehydration and worsen kidney problems. Talk to your doctor.

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From the publisher

Urologist and informatics leader Dr. Denise Asafu-Adjei joins Dr. Mills to break down how AI is quietly transforming men’s health, from AI-powered scribes that free doctors to actually look patients in the eye to chatbots that could triage symptoms and streamline access to care. They dig into the big questions patients (and physicians) are asking right now: privacy, accuracy, and whether technology will ease burnout or simply fill every last “free” minute on the schedule. Plus, Dr. Denise (@drdenise_official) shares where the field is heading next — including mind-blowing fertility advances like AI-assisted sperm identification — and what it’ll take (education, policy, and better data sharing) to make the future of medicine both smarter and more human.

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