In short
Explains ejaculatory disorders—especially premature/rapid ejaculation and delayed ejaculation/anorgasmia—by separating ejaculation vs orgasm, describing the ejaculatory reflex arc (frenulum sensitivity; T10–T12) and hormone/nerve roles (dopamine, serotonin, oxytocin, testosterone, prolactin).
Key claims
Premature ejaculation is usually a reflex/timing issue, not “health failure,” and can be treated by reducing frenulum sensitivity (OTC topical creams/sprays), and sometimes SSRIs (off-label) to raise ejaculatory threshold. Delayed ejaculation may involve desensitization/conditioning (e.g., “death grip”), medication effects, or reversible causes like high prolactin from prolactinoma; cabergoline can help.
Notable examples
Post-prostate-cancer patients may still orgasm despite loss of ejaculation fluid; a fertility patient with prolactin ~500 had a prolactinoma and regained orgasm/ejaculation after cabergoline.
Guests
Dr. Jesse Mills (urologist/sex-medicine clinician) interviewed by Jordan Runtah; host Cal Penn appears only for promo segments.
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VOCasual Check-In
1:50 to 2:20
Hosts discuss their recent lives and experiences, including allergies and holidays.
“There's a difference between liking a house and actually getting it.”
Casual Check-In
2:23 to 3:39
Hosts discuss their recent lives and experiences, including allergies and holidays.
“Talk to me about what's going on in your life right now, man.”
Citrus Grove Tales
3:39 to 6:41
Discussion about citrus trees, gardening, and personal experiences with plants.
“I mean, all kinds of just fun California things to do.”
Transition to Medical Topics
6:41 to 7:36
Hosts shift the conversation toward medical topics related to sexual health.
“I promise that's sort of a 17th or 18th century insult.”
Understanding Ejaculatory Disorders
7:36 to 14:37
In-depth discussion on ejaculatory disorders, physiology of ejaculation, and orgasm.
“So talk to me about, well, you tell me what you know about premature ejaculation, delayed ejaculation.”
Common Issues with Ejaculation
14:37 to 16:47
Learn about premature ejaculation and its prevalence among men.
“So a guy can either come too fast or he can not come at all.”
Expectations and Reality in Sexual Performance
16:48 to 18:40
Discuss how societal expectations affect men's sexual performance.
“And most of time guys don't complain that it gets to the point where they can't have any sensitivity at all.”
Expectations and Reality in Sexual Performance
18:57 to 19:19
Discuss how societal expectations affect men's sexual performance.
“See how the GeneSight test may help you spend less time at your doctor's office.”
Expectations and Reality in Sexual Performance
19:24 to 20:18
Discuss how societal expectations affect men's sexual performance.
“and delivers the soft, fluffy, flavorful experience you love.”
Expectations and Reality in Sexual Performance
20:19 to 20:51
Discuss how societal expectations affect men's sexual performance.
“See nutrition info on Hero.co for sodium and sugar content.”
Show all 24 chapters
Defining Normal in Sexual Performance
21:37 to 23:55
Understand what constitutes normal timing for ejaculation.
“Backing it up a little bit, you talked about too soon, too late, for lack of a better term.”
Psychological Factors in Sexual Performance
23:56 to 26:17
Examine how psychological issues affect sexual performance.
“And really the therapy for that depends.”
Addressing Death Grip Syndrome
26:18 to 28:00
Discuss the implications of 'death grip syndrome' on sexual function.
“I mean, I haven't heard of death grip syndrome, but boy, now I can't unthink it or unsee it probably.”
Understanding Serotonin's Role in Ejaculation
28:00 to 31:24
Learn how serotonin modulation can affect ejaculatory control and treatment options.
“which you talked about as one of the hormones in that ejaculatory pathway, serotonin.”
Balancing Antidepressants and Libido
31:24 to 33:29
Explore the challenges of antidepressants affecting libido and potential solutions.
“It's interesting that you prescribe SSRIs for this.”
Navigating Myths Around Male Sexual Health
34:47 to 38:04
Discuss common misconceptions and the importance of consulting professionals for ejaculatory disorders.
“Are there things that guys should absolutely not do that maybe are myths out there that are old wives' tales that people should steer clear of?”
The Importance of Communication in Sexual Relationships
38:04 to 40:04
Understand how communication can improve sexual experiences and performance.
“So again, it goes back to communication being the most important thing to any sexual encounter, either pre-game, intra-game or post-game.”
Prolactin Levels and Delayed Ejaculation
40:04 to 42:00
Learn how high prolactin levels can affect ejaculation and potential treatments.
“Maybe you should call audibles and sex, but I think only when you're to the point where you communicate and you're such a field marshal that you have command of the situation that you can do that.”
Understanding Prolactinoma and Delayed Ejaculation
42:00 to 43:36
Learn about the impact of prolactinoma on male sexual health and treatment options.
“And he had a big fat tumor on his pituitary gland called a prolactinoma.”
Oxytocin Supplementation for Ejaculatory Disorders
43:36 to 45:26
Discover how oxytocin nasal spray may aid men with delayed ejaculation.
“And there's studies out there on this, again, not FDA approved, very off label, but relatively safe side effects.”
Importance of Medical Evaluation for Sexual Health
45:26 to 46:15
Understand the necessity of thorough medical evaluations before treatment for sexual issues.
“So again, you're probably going to be okay.”
Casual Banter on Fishing and Personal Life
46:15 to 46:34
Enjoy light-hearted discussion about hobbies and fishing experiences.
“and was basically able to solve the entire problem of too much too soon or not enough too late.”
Casual Banter on Fishing and Personal Life
48:09 to 49:40
Enjoy light-hearted discussion about hobbies and fishing experiences.
“It is not a substitute for professional medical advice, diagnosis, or treatment.”
Casual Banter on Fishing and Personal Life
49:43 to 50:43
Enjoy light-hearted discussion about hobbies and fishing experiences.
“Everyone has free phones, but when I switched to T-Mobile, I got more value and so much more.”
Transcript
Automatic transcript. May contain errors.0:00This is an iHeart Podcast. Guaranteed human. What's up, y 'all? Summer's got a different tempo. Everything's a little looser, brighter. One plan turns into another. You hear something, you stay a little longer. Next thing you know, you're somewhere you didn't plan to be. It's those in-between moments. That's where the ideas hit. Conversations stretch out. Little memories sneak up on you. Sometimes, it's just about what's in your hand. That color. That chill. The new tropical butterfly refresher from Starbucks. Guava and passion fruit flavors with mango pineapple flavored pearls. Yeah, that feels like summer before you even taste it.
0:40Funny how one small stop becomes the best part of the day. Start your summer rhythm with Starbucks. Try the new tropical butterfly refresher from Starbucks.
0:54Hey everyone, it's Cal Penn. I'm inviting you to join the best sounding book club you've ever heard with my podcast, Earsay, the Audible and iHeart Audiobook Club. Every episode, I nerd out with amazing guests and dive into the best new audiobooks available on Audible. It's the book club for your ears. Listen to Earsay, the Audible and iHeart Audiobook Club on the iHeartRadio app or wherever you get your podcasts.
1:48We'll be right back. delivery for most internet eligible customers. See if it's an option during checkout. There's a difference between liking a house and actually getting it. Redfin is built to make up that difference and close the gap between finding and owning the home for you. Redfin agents close twice as many deals as other agents. So when you find a home you love, you're not a step behind when it comes to making an offer. That means less watching great homes disappear and more focus on the one you'll call home. Redfin helps turn saved listings into real addresses. Get started at redfin.com.
2:22Own the dream.
2:42Welcome back to the mail room. Jordan Runtah in the house. How you doing, man? You sound a little stuffy, maybe. Talk to me about what's going on in your life right now, man. Man, I went up to visit my folks for Memorial Day. I grew up on a lake in central Massachusetts. Seems like the perfect place to do some grilling, hanging out by the dock. But I got here, and the place was yellow, just pollen everywhere. And I've got nuclear-grade allergies right now. Sorry, everybody. Spring has sprung. No, man, I think, you know, you're like half a register from Barry White. We should lay down some tracks.
3:20No, it's all good. You wear it well. But allergies suck. I've been blessed to not have those. But yeah, bummer. Yeah. Do you do Allegra and all that stuff? I'm on everything right now. No, just the whole cocktail, seeing what works. Yeah. God bless you. How was your holiday? It was good. You know, just did my run, got in the sunshine, worked on my citrus grove. I mean, all kinds of just fun California things to do. What is your citrus grove? Wait, what is your citrus grove? So I, you know, we moved back to California and I grew up here, you know, pretty much. And I was gone for almost 20 years.
3:52And I said, if we're moving back, I really, I got to have an orange tree. I got to have a lemon tree. We actually grew a lemon tree in Colorado that I would take out every winter. I would bring in rather than in the summer, I would take it out and it would grow it on the deck. I mean, I was so citrus fixated because to me, that's like the sign of just, you know, it's live and it's so good and fresh citrus. And I remember the first summer took two to three years of growing this lemon tree, about four or five feet. You know, it was a big ass planter and we had it on rollers so I could roll it in and out in the Colorado sun, which is amazing and it's incredible.
4:25But obviously the winners, we had to bring it inside into our little solarium. And I was growing this lemon and I was so excited. It had this beautiful lemon. It was green. It was just starting to get a little bit yellow. And then a squirrel ate it and it was the worst. The thing that was so bad about it, because I love my nature and our wildlife, but it just, it hated it. It cut it, it bit it out, and it tried to eat it. It was like, this sucks. And so this lemon that I've been nurturing for months to have my first lemon off my Colorado lemon tree, this goddamn squirrel ate it. So I was so pissed.
5:00Didn't get to enjoy it. And then finally, you know, got the call to come back to UCLA, and I said, we're having trees. And so it started off with, like, one lime tree, and then I got a couple Meyer lemon trees. And now I've got navels and pomegranates, which I know are not citrus, but they're in my little grove. I've got grapefruit trees. I've got a couple of Eureka lemons, a couple of tangerines, kumquats, kalmandin, you know, those little delicious kumquat-like varieties are fantastic. Yeah, so I have about 13 or 14 trees that I love to tend to as sort of my outdoor therapy and getting a little bit of the sunshine.
5:34So, yeah, and I'm not allergic to any of those things. So sucks to be you, man. I was going to say, my hometown is the birthplace of Johnny Appleseed, so we're an apple. No way. Yeah. All right, what's your favorite apple variety? Is it Cosmic Crisp? Gotta go Fuji. Oh, really? Okay, yeah. I got turned on to the Cosmic Crisp, which are absolutely fantastic, but yeah, Fugees are great. Yeah, they're kind of a West Coast thing. I think they're grown in Washington, but they're pretty delicious. So that's what I got going on. You are a man of many talents. I don't know about that. Musicians. surgeon, wood major, and grove master.
6:13Grove master, yes. I did spend time when I was a kid. I had a really good friend whose dad had a citrus farm and avocado farm. So I did learn a few things when I was growing up and we spent the weekends down there in San Diego. So maybe I had that, but bottom line is it's great to have your own fresh citrus. So cool. Amen. So that's my deal. Hey, should we do something like medical or do you want to just talk about citrus? And well, we did start out with allergies, for example. I love vitamin C. Vitamin C, scurvy. That's where you get limeys from. No offense to my British listeners, by the way.
6:42I won't call you limeys anymore. I promise that's sort of a 17th or 18th century insult. But it's a supplement that works. Vitamin C is a supplement that works. So you heard it here. Not all supplements are bad. Yeah, I don't know. I was thinking about talking about ejaculatory disorders because when we started this gig a while back, one of our first guests was Natalie Feingold-Goldberg, who is a sex therapist. And we brought up premature ejaculation, brought up delayed ejaculation, touched on a little bit, but it's something that's so common in my practice that I thought maybe we actually do a little Q &A with what's on your mind, as well as a little physiology for our, and anatomy, I guess, for that matter, for our listeners out there, just because I think it is something that you can't talk about enough.
7:24And it just always comes up and it can be vexing for my guys, as well as the partners they're with. So let's talk Welcome to the mailroom. Let's talk about it. Yeah. So talk to me about, well, you tell me what you know about premature ejaculation, delayed ejaculation. What's the difference between ejaculation and orgasm, for example? Okay. Ejaculation actually is the release of sperm. Boom. Sperm. The money shot. And orgasm is something more internal. Orgasm is the euphoric feeling of when one expels a load of semen. Yeah. So that's the difference between ejaculation and orgasm. So there are guys, the most common are men after prostate cancer surgery, where we take out their ejaculation organs, which are the seminal vesicles and the prostate where the fluid is made, but they still have orgasms.
8:15In fact, sometimes they have more intense orgasms afterwards because they don't have that fluid to expel. So the same muscles are just squeezing joy and euphoric feelings up in the brain. And so orgasm is that sensation. and ejaculation is the fluid. So actually, I think that's a reasonable place to start. So I think about ejaculation and orgasm in physiologic anatomic terms. So there is a nerve that is on the tip of the penis in the area we call the frenulum, which is if you're standing up, looking down at your penis and you see the head right on the opposite side of that head. So at the six o 'clock position, that's an incredibly sensitive part of the penis.
8:58And it's also we call an ejaculatory reflex arc, which comes about midway into your spinal cord around T10 to T12, somewhere in there. And it is what causes us to have a orgasm through stimulation, which would be either hand, mouth, vibrator, orifice, anus, vagina, however, pillows, whatever. You know, there's a lot of different ways that guys can generate an orgasm and an ejaculation. And it does stimulate that T12 reflex arc. And so even in guys with spinal cord injuries, interestingly enough, if their injury is above that area, they can actually still have an ejaculation and potentially an orgasm because that arc is intact.
9:44So that's the beginning of this. The deeper center for orgasm actually is in the tiny sympathetic nerve fibers that surround the prostate. And so there are guys that talk about having prostate orgasms, and that's a real thing too, because you can stimulate the nerve fibers right at the level of the prostate, usually through rectal massage. Rarely can guys do it through the perineum because it's a little bit too much skin in the way. But essentially, that's the other way to have an orgasm is through prostatic massage. and now we go up to the brain and there's about five different hormones that are necessary for a guy to be able to have an orgasm and ejaculation just guess one you have five different ones so just give me one i feel like you're one of my medical students now dopamine yeah okay that's yeah damn dopamine good yeah i mean that's that's number one dopamine is that feel-good hormone so that's one serotonin yeah number two why are you googling this come on open book yep dopamine serotonin oxytocin oxytocin wow there's two more i mean the big one that like you know everybody and everybody and everybody's on it the big t man testosterone oh Oh, duh.
11:03And then the last one is prolactin. So you got the three hard ones. Yeah, yeah. So any disorder in any of those or any drugs that we take can cause disorders in ejaculation based on how they perturb any of those levels from testosterone to dopamine to everything in between. So in order to have a good intact orgasmic response, and by the way, those are pretty much the same in women as men. All those hormones are conserved across gender. And so even testosterone. So women that have hypoarousal disorder, where it's very difficult for them to get aroused or have orgasms, often have low testosterone.
11:37So you got to have hormones and you got to have nerves. And those are really the two different ways that we think about orgasm. And so when we think about disorders of orgasm and ejaculation, we think about them as a spectrum of timing. And what I mean by that is there are men that have incredibly shortened ejaculatory responses where they, what we often refer to as premature ejaculation or rapid ejaculation, where briefly after stimulation, sometimes even prior to penetrative intercourse, a man will ejaculate. And that is almost always a reflex issue. And when I try to unshame this and a guy comes into me, because again, this is something guys get judged with, they get compared to other partners with.
12:24It's an incredibly shameful thing for guys to go through. And it doesn't have to be. The reason for that is that when I went to medical school and I did my rotations, one of the rotations that we did is in neurology where we all walked around with their reflex hammers, Maxwell's silver hammer for Beatles fans out there. which I think he used for very different purposes, but it probably started off as a reflex hammer. And it was this little rubber mallet that you would hit right under the kneecap. And that was a great way to test our reflexes. I'm sure if you're at any high school physical, everybody remembers sitting down in the doctor's office with their knees hanging over the bed and she or he hit your reflex and you kicked your knee out.
13:04And we graded that from zero to two, I believe, or two plus where a guy could be hyper reflexic. So those knees, that knee reflex, and the same thing we can do in the elbow is very important for our ability to know how well we're doing neurologically. And if a guy has diminished reflex or hyperreflexia, there could be a neurologic condition. Well, I kind of look at ejaculation the same way because I just said that that reflex arc at the tip of the penis is very important for determining how much stimulation you need to form an ejaculation. Some guys, the wind blows funny, boom, you know, they ejaculate.
13:42Some guys, they can have penetrative sex for minutes upon hours and not be able to ejaculate. And a lot of that is delayed reflex. So that's the way I look at this. I talk about physiology and, you know, I'm good friends with and colleagues with Natalie Feingold-Kolberg, who we had on a few episodes ago, 20-odd. and we talk about that, that a lot of my sex therapists, you know, they want me to correct the physiology so that they can deal with the psychological manifestations of the physiologic or anatomic abnormalities. So whether it's about the size of a guy's penis or whether it's about how quickly they ejaculate, there are things I can do anatomically and physiologically to improve those.
14:21So then my therapist job is a little bit more, I don't know, synergistic. We work together better that way. Okay. So that's the anatomy, the physiology of an ejaculation in six short minutes, I'm just guessing on the time. So what can go wrong? So a guy can either come too fast or he can not come at all. And what can we do to treat all of those? And so I think what I would love for you to do, because I just feel like I talk all the time, Jordan, I want you to put on your journalist hat and pretend like I'm not Ringo Starr. But, you know, as a Rolling Stone journalist extraordinaire, you know, in your former life, interview me.
14:59Tell me what you want to know about ejaculation, the good, the bad and the ugly. What are the most common issues that you see in your practice? I think the majority of guys, and I think this bears out in the literature and surveys, is that most men are more concerned with premature ejaculation. It is something that especially happens, we think, in younger people. And often it starts off with less experienced men because all of this is new to them and their nerves. And so it's something that is prevalent. And there are all kinds of treatments out there, including a lot of off-label things that we use.
15:34In fact, there's actually no FDA approved drug for premature ejaculation. So whatever I write for, if I'm writing a prescription, it's not going to be FDA approved. But yeah, I would say premature ejaculation is the most common one. So the first thing I want to do is rule out any other things going on. You know, I do a full evaluation. Often I will even check hormones because I just don't want to miss anything. But most of the time, the guy with premature ejaculation is perfectly healthy. otherwise it doesn't really indicate any other underlying hormonal pathology or any neurologic dysfunction and it's just a matter of how do we diminish that trigger how do we diminish that t12 reflex arc or that pathway at the frenulum and so for me the common treatment for this is is to do something to diminish the sensitivity not to the point where the guy is numb or not to the point where he could spread any treatment i give to him to his partner especially having a penis and vagina panasex or PNV sex.
16:32But there are really good over-the-counter topical creams and sprays. You can get them online. You can get them at CVS, Target, I think, anywhere that, and I don't endorse any of these, but they're pretty easy to find in Google, is to help decrease that sensitivity so that when a man's having direct stimulation of that area, they don't have that quick trigger. And so I think that's first line. Anybody, it's safe, it's effective. And most of time guys don't complain that it gets to the point where they can't have any sensitivity at all. It's just enough so they can have incredibly meaningful sex and last longer than they would without it at all.
17:08So that's my, that's my first line therapy. Now, do you see, have you noticed in your practice that younger men these days are having more issues with ejaculation than men previously? You know, I think it's what it is, is just becoming much more prevalent and much more talked about. And, you know, one thing we also didn't talk about, which was huge in the zeitgeist is ejaculate volume and this idea of load maxing and shooting ropes. And again, that goes back to what it all goes back to. It seems like when we talk about sex on this podcast is what are your expectations based on what you see on the internet or in pornography?
17:42And so it goes back to the athleticism of some of our adult entertainers that are able to ejaculate volumes of semen and be able to hold their ejaculation through what seems like interminable sexual relations. and that to the average guy, especially some that's not so sexually experienced, thinks that that is what they aspire for. And again, as we talk about so often in the show, most people, especially, well, I should say, most people that have vaginas are not orgasming through penetrative intercourse. And so sometimes too much can actually be too much. And so this is not the goal as to how long are you able to hold out before you orgasm.
18:22But if you do have a partner that does orgasm through vaginal intercourse and you can time it, then this idea of simultaneous climax is a pretty great aspirational thing, but functionally it doesn't really happen that often and is something more in romance novels and in fireworks on scene. So again, don't aspire for something that probably doesn't exist that often in nature.
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21:37Backing it up a little bit, you talked about too soon, too late, for lack of a better term. In real numbers, what is a realistic, what is the normal amount of time? And I hate using the word normal, but... Yeah, I love it. No, actually, there are clinical definitions of what we consider premature ejaculation. And really, the best definition I have is that any time that a patient or his partner is not satisfied with the length of time prior to ejaculation and orgasm, that is what I would consider not long enough because there are some guys that, again, have such severe, I think, is reasonable to say premature ejaculation, rapid ejaculation, that they're having an orgasm prior to even having penetrative sex.
22:22And so that's on one end of the spectrum. The typically agreed upon term is, you know, somewhere under a couple minutes. It's, you know, the average sexual expanse from insertion. Again, this is based on penis and vagina sex for the most part, because that's what we have standardized questionnaires for. Unfortunately, we don't have great other alternative methods of having sex from anal and oral intercourse. But it is this two minute to five minutes is kind of a normal time from insertion to orgasm. And so that means anything greater than that. If again, it's causing discomfort to either the patient or the partner, then that could be delayed ejaculation.
22:59And so really the sweet spot depends on the couple. You know, for some it's the partner comes first and then it's just a matter of the man or the person with the penis that is able to finish whenever at their leisure because the other person has already achieved orgasm. Then premature ejaculation, delayed ejaculation becomes less of an issue. And there are some men who struggle to orgasm during partnered sex, even though when they're alone, that is not a problem. other than performance anxiety or any kind of other psychological issues. Are there some physiological reasons for that? Yeah, I mean, there are.
23:35I mean, I think that I kind of not joke about it, but I do want people to kind of think about the fact that if a man has been used to the feeling of his own hand and grip strength for a long period of time and spends a lot of time in masturbation, then that's a feeling and that's a neurologic condition response that when he goes to have penetrative intercourse with a partner, it may not feel the same way to those nerves and so there can be a desensitization to that i'm not here to judge on you know what the appropriate amount or the ratio of of single versus partnered sex should be because i don't think anybody has an answer to that except for if it becomes a problem where it's pathologic and somebody's having more partnered or more solo sex than partnered sex and the partner's like hey what's going on then that becomes a problem but but for sure it's not as simple as just a psychological issue saying i can't orgasm with my partner, but I can by myself, but it can be definitely a relationship issue that needs to be explored.
24:32And really the therapy for that depends. Sometimes it is sex therapy. Sometimes it is not having solo sex and manual sex for a period of time, and then having engaging in normal penetrative intercourse with a partner that can help some guys through this. But yes, a condition response is for sure. I mean, again, it's a neurologic issue. And if you desensitize the penis or you get used to only one sensation to orgasm it's the same thing with positions i mean there's some men that can only orgasm in one position versus another position and it's that same condition response some of that isn't pathologic as long as you're okay with it in other words as long as you and your partner are okay and you're both sexually satisfied then everything else is just judgment and we don't judge here man i guess dumbtail with that there's a phrase that's become very buzzy I've seen on the internet lately.
25:22I was curious if it's crossed your path in your practice. Death grip syndrome. Does that mean anything to you? Well, I can only imagine, but obviously we have different feeds. I mostly get updates on my sabermetrics on my Dodgers and my inbasket. But okay, Jordan, again, I'm not judging. I've not had any death grip syndrome feet. But it sounds like, yeah, guys are probably using way too much manual grip strength in order to induce an orgasm. So they're used to that incredible level of grip strength, or just the right amount of stimulation, which again, goes back to the whole deal is if you're only doing it one way, then that can condition that response so that that's the only way you're ever going to orgasm and your partners don't stand a chance.
26:08And I think that is much more common than And we think, and one that probably does take a lot of retraining and maybe a little bit of sex therapy, but mostly probably neurologic reconditioning so that they can have a better sex life and not induce death grip syndrome in order to have that same ejaculatory response. That's sad. I mean, I haven't heard of death grip syndrome, but boy, now I can't unthink it or unsee it probably. And I'll go back to my office today and have three guys that have death grip syndrome in my clinic because of you now. Death grip. Weren't they one of the big four in post-punk?
Read the full transcript
26:41Yes, that's right. Exactly. They opened for circle jerks. So there you have it. Death grip syndrome. If not, we're doing it. We're starting our own band right now. DGS, baby. Did you catch DGS at CBGB's? Oh, yeah. 78, that show. I was there, man. I was in the front row. But the Red Hot Chili Peppers wearing socks on their dick. I think you're thinking of death grip for cutie. I mean, they really launched this entire choking vocals kind of indie punk sort of thing. It was really big in the late 90s, early 2000s, Death Grip for Cutie. I think they're probably Hall of Famers by this point. Oh, man, we could go on.
27:24Yeah, we're keeping all of this. Of course we are. Yeah, because again, I mean, the theme of this is also you're probably going to be okay that there are so many treatments. And so we, you know, getting past what we were talking about with the premature, and I'm, by the way, not trying to reroute you at all because I could talk punk rock forever. But, you know, somewhat a medical show. I think we're still in that category. Haven't quite got to the entertainment level yet. But rerouting to thinking about premature ejaculation. So topical sprays, topical creams, first line. But there is a whole branch of relatively good data on looking at starting guys on SSRIs, which you talked about as one of the hormones in that ejaculatory pathway, serotonin.
28:07So if you can modulate serotonin levels through taking the drugs that we usually prescribe for antidepressant, that could be a game changer for some guys. And I think that's really, really interesting. And I've certainly used those over the 20 odd years I've been treating guys with premature ejaculation to a good effect. And you often do, I always start at a lower dose. And again, this by no means is medical advice, just so we know this. But if you were in my office and you were actually my patient, I do often start at a lower dose than I would when a guy would be treating depression with antidepressants.
28:41And sometimes that can be effective at just taking that serotonin level to the point where a guy's ejaculatory threshold gets up a little bit, it takes a little more stimulation to make that release and to cause that orgasmic cascade, which then leads to ejaculation. So SSRIs are, I would say, first to second line therapy for this. And the other therapy that some people have tried is more of a dopamine modulator, and that's something called Ultram. Tramadol is a generic name. Now, the problem with tramadol is it's also considered a little bit along the controlled substance narcotic pathway. And so it never, it was years ago, part of a clinical trial or an advisory board looking at bringing tramadol on at a slightly different dose than what we use for post-operative pain as a premature ejaculation, FDA approved drug.
29:31And it ran into a couple of problems. One is it was already generic. So there was no market for this because you could write for it anyway. And it was pennies on the dollar. But two is because the concern is that it could be habit forming. And it was never really panned out very much as being habit forming, especially at the dosing and the on-demand way that we would prescribe it for premature ejaculation, because you just took it ahead of a sexual encounter, just like you would take a drug like sildenafil or tadalafil for erectile dysfunction. But again, it never got FDA approved, not only have they made it to a clinical trial, may not have even made it past that advisory board, because I think from a financial standpoint, it's really tough to go to the FDA and get in a drug approved that already has an indication and is generic.
30:13There's just no there's just no money in it but but tramadol would be another one that some people use there also are medical devices out and there are a couple of these that do have that i think are pending fda clearance that are available overseas that essentially are like nerve stimulators that you wear behind the testicles in that area that we lovingly referred to as the taint or the perineum where you place a little patch that's the size of a posture stamp and it actually hyper polarizes or causes the nerves to fire a little bit less aggressively and it can delay the ejaculatory response.
30:47And the clinical trials in that are actually pretty good. And so that's a device that'll be a disposable that, again, somebody will wear just prior to intercourse. And it can be so discreet that your partner may not even know that you have it because it's so small. It's just a couple of little electrodes and it's safe. It's not going to shock you or anything, but it is something that can cause a little neurostimulation to delay ejaculation. So I'm kind of interested in that. Again, don't have right now have no financial interest in any of the companies or no consulting for any of those companies.
31:17But but certainly as as an observer and an intellectual, I think that could be a new future for guys with premature ejaculation. It's interesting that you prescribe SSRIs for this. I was going to ask you about what happens because you hear all these stories about people being put on antidepressants and then their libido goes down. Right. In extreme cases or extreme cases perhaps, I should ask you. How do you deal with kind of the inverse of that? Yeah. Yeah, I mean I think that's a big problem. So that goes back to why we discovered this would be an interesting therapy for guys with premature ejaculations.
31:48The guys are on full depressant doses. So you know what? I have not been able to have an orgasm since I've been on these medications and my depression is better. But now I'm kind of upset about this untoward side effect. And so there is a balance. And there are a couple of medications that do better for treating depression that have less orgasmic effects. And those you can certainly talk to your primary or psychiatrist prescribing and they'll know what they are that you can try those instead because some of them have dopamine pathways and some of them have norepinephrine pathways. And so they do modulate differently than just pure serotonin reuptake inhibitors.
32:27And so that's definitely worth having a conversation on. And when I see a guy that's on more traditional pure SSRI, that might be my first thing is check back in with your psychiatrist because there may be something out there that is a little bit better for sexual function that still gives you the benefit of not having the depressive symptoms that got you on that medication in the first place. So yeah, there are better alternatives out there than the classic SSRIs that have been out for 35 years now, at least.
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35:00Are there any ways that you could think of offhand that men well-meaning who are maybe too shy to go speak to a doctor about this will try to help their own, to treat their own, what they may view as performance anxiety or erectile dysfunction or ejaculatory disorders and actually accidentally make it worse? Are there things that guys should absolutely not do that maybe are myths out there that are old wives' tales that people should steer clear of? I mean, I guess for ejaculatory dysfunction or erectile dysfunction, there really are very few to no reasonable supplements that I would recommend.
35:36So I'm sure it's just, it's a scary, scary world out there. And again, a lot of the supplements that are on the erectile dysfunction pathway, especially ones that may have any effect at all, have contraband sildenafil to dalafil in them. So the ED, the pharmacologic ED drugs are in there. and I would hasten and hazard to guess that maybe some of the vitamins or supplements that people would be marketing for premature ejaculation may have SSRIs in them in the same level. Don't know that at all, but it sure stands to reason that if you can go to a truck stop and buy a truck stop Viagra that actually has Viagra and is not just horny goat weed and ginseng and L-citrulline or something, it does actually have an active FDA-approved ingredient in it.
36:20I bet they're doing the same thing on premature ejaculation. So the answer is, yeah, don't. Just don't. Go and talk to your physician about it and get on a real pathway that even if it's off-label like the SSRIs are for premature ejaculation, it's still possible. And that really is the same with delayed ejaculation. I think the other thing that we talked about with Natalie Feinke-Goldberg that I think is really interesting is that there may be a role for pelvic floor physical therapy in both improving ejaculatory response from a premature or a delayed ejaculation standpoint. And there are pelvic floor exercises that can make us have a little better control of our ejaculatory response.
36:57So again, I would go to pelvic therapy before I think about buying any supplements that would report that or any medical devices that don't have any good data behind them. So yeah, be careful what you come across because it's an incredible market out there of things that you can try that really don't have efficacy. And potentially some of them have dangers like hidden prescription drugs that you may have a response to. For example, if you're already on an antidepressant and you still have premature ejaculation, then you take a drug or a supplement that may have snuck in some, that could not be great to be overdosing on that.
37:31Same thing as if you're taking an ED drug and then you take another one at a truck stop or if you have heart conditions that you need to take medications where those drugs are absolutely contraindicated, you could end up really harming yourself. So yeah, really be careful of anything that you see over the counter and anything in the supplement world, anything you can buy online. It was a broad question, but I'm interested in your take on it. What is the healthiest way to think about ejaculation and performance? Because I feel like so much of it is people getting in their own heads. Yeah. You know, I think it goes back to if it's with a partner, it's having that communication, you know, and what feels good to both you and the partner and then having that discussion, especially if you have a history of having either difficulty achieving orgasm or premature orgasm, those are two things that your partner should know because a lot of people will take it personally if a guy has delayed orgasm and they're with a new partner and he has a physiologic or neurologic reason or he is on medication that he has to be on and you don't communicate that up front and you're 10 minutes, 15 minutes, 30 minutes, 60 minutes into an session of intercourse and it hasn't happened, that person may take it personally if you didn't say, hey, look, I just got to let you know ahead of time, this is kind of an issue for me.
38:49So again, it goes back to communication being the most important thing to any sexual encounter, either pre-game, intra-game or post-game. And especially post-game, if you find something that really did work, then you want to be able to talk about that and say, hey, this was really effective for me or this was great. you got to let that partner know. So you got to know what, what to look forward to next time. The main takeaway from a lot of these episodes lately has been talk about it. Yeah, man, let's talk about it. It's, these are things that also that, that it's so hard to talk about. And I, again, I always go back to how grateful I am for the career I have where men are able to come to me and, and speak with me and talk with me about these conditions that they may not have had that conversation with their partners yet.
39:32And sometimes I hear back from them and And say, you know what? That was actually the best thing we ever did is we sat down, we talk about it. And my advice I always hear from my sex therapy colleagues is that you want to talk about sex, not in the bedroom. You want to talk about it somewhere else and then bring it to the bedroom. So, you know, if you're going through your X's and O's and your chalk talk, you do that in the locker room and then you get on the field and you play your game. So don't start doing a game plan mid game. Don't call audibles and sex. That seems very restrictive. Maybe I don't want to say that.
40:05Maybe you should call audibles and sex, but I think only when you're to the point where you communicate and you're such a field marshal that you have command of the situation that you can do that. But for the most part, it's really good to talk about this so that everybody's expectations are on the same playing field, the same level to know what we're all getting ourselves into with this beast with two backs. Damn, we got Shakespeare today, Jordan. Wow. Right? Just seemed to flow. Post Punk and Shakespeare. Post Punk and Shakespeare, same episode. You heard it on the mailroom. So yeah, I think, right, for all of these things, it is just knowing that there are therapies out there.
40:47Also knowing that, especially for delayed orgasm, the medical therapies are very, very limited. You know, we really just, we have zero FDA approved, but there are some things that work. You know, one of the things we talked about is prolactin, is one of the hormones that has to be at a good level for an orgasm. And if your prolactin levels are too high, it can actually inhibit orgasm. So there are medications off-label used for other reasons that you may have some success with. The classic one is something called cobergoline, which lowers the prolactin levels. We use it for guys that have, or women too, that have pituitary tumors where they're secreting too much prolactin.
41:26And we knew that. Again, that's another cause of delayed ejaculation that you should see your doctor about because if he had normal orgasm, normal orgasm, let me tell you a story, actually. I remember this when I was in fellowships, this was 20 plus years ago, and I saw a very nice, he was a PhD student and very smart, obviously, and he was in his 30s and they were coming to us for fertility issues. And the main problem was that he couldn't provide a sperm sample, nor could he orgasm with his partner. And the partner was taking it very personally as would happen. And he said, look, it has never been a problem before, but all of a sudden i've not been able to orgasm and i said well that's interesting i mean no saddle traumas you're not riding your bike 600 miles a day you're not doing any don't have any numbness nope no numbness everything's fine no pelvic trauma and we test all his blood work his testosterone levels all of his hormones and then we also tested his prolactin and his prolactin came back in the 500 range which normal is anything less than 16 and so this guy had a pathologically high secretion of prolactin, which prompted us to do an MRI of his pituitary gland because that's what you got to do.
42:35And he had a big fat tumor on his pituitary gland called a prolactinoma. That's the most common reversible cause other than medications of delayed ejaculation or change in orgasm is prolactinoma. And it's not cancer. It's treatable often with medication. And guess what the medication is? Cabergoline. And so we actually can take a guy with a brain tumor, which sounds horrific, and then reduce it by putting them on a drug that makes the tumor shrink, makes the prolactin levels go down. And this couple was not only able to, he was able to have an orgasm, but they were able to ejaculate and make babies a good old fashioned way just because he had this strange tumor.
43:12And I actually, you know, in my practice, where certainly I take care of thousands of guys every year, but every, you know, I would say two to three times a year, I will pick up a prolactinoma. So it's not the rarest thing in the world by any means. And so So, so cobergoline, we use off label to treat guys with anorgasm or difficulty achieving orgasm, even if their prolactin levels are just a little bit high or even high normal. And there's studies out there on this, again, not FDA approved, very off label, but relatively safe side effects. And so with proper patient counseling and selection, that is probably one of the more common things we see to help guys with delayed ejaculation.
43:50But you got to make sure they don't have anything more serious going on first. the other crazy one which isn't so crazy but also because you either did your homework or just knew you talked about something called oxytocin which is part of those hormones and there are guys that have low oxytocin that they may benefit from oxytocin supplementation usually through a nasal spray which also has there's a british medical journal article from like 2006 so this is again not cutting edge by any means, but showing that guys that have delayed ejaculation by taking an intranasal spray of oxytocin mid-coitus, so it's almost kind of like, hang on, babe, I got to switch over here and just take a little puff.
44:30And that actually, because oxytocin is such a short half-life, like on the order of about eight minutes, that it actually can improve that ejaculatory threshold and cause orgasm. I've had very limited success with that, but the guys that it worked for, they're super happy because it's safe. There's really no downside to it. and this is a compounded drug. There is no pharmaceutical form of oxytocin, so you have to get it from a specialized compounding pharmacy. But you can certainly talk to your local doc or your local sex med specialist probably to at least try a trial of oxytocin nasal spray or they have trochees under the tongue as well.
45:05But I think the nasal spray is the only one that's actually been really studied. So you got to make sure you're getting it from a great pharmacy that has a good track record. And another thing to potentially try to help improve that anorgasmia or difficulty achieving ejaculation. I had heard of oxytocin supplements. I did not know that it was administered that way. Wow. Yeah, yeah. So again, you're probably going to be okay. Rule out the bad stuff. Number one, all we do in medicine, and the reason the only thing I have against telehealth or direct-to-consumer medical or supplement sales is you have to do the evaluation because no matter what condition we're going to talk about on the show, So you need a good high-level medical exam, most likely a physical exam, very most likely blood work before you can just treat this stuff and not worry about it.
45:52Because what if you did have something that needed the medical treatment that could be reversible, could be serious if you didn't reverse it and you just started getting brown paper bags in your mailbox every month. So not cool. You don't want to do that. You want to make sure you get the evaluation and you have a good doc that's in your corner. Well said, my friend. Yeah, man. So we started with orange trees, ended up with some punk rock, and was basically able to solve the entire problem of too much too soon or not enough too late. And we did it again on the mailroom. That's what we do here, my friend.
46:26Jordan, this is too much fun. I mean, I love our guests. I also just love hanging with you and talking through this stuff. So we should probably do it again sometime. I'll let you get back to fighting your allergies and breathing in that beautiful Massachusetts lake air. Are you going to go fishing? Do you fish up there at all? I do fish, actually. Yeah, I got some bass up here. Nice. No, it's nice up here. Oh, yeah. Well, that's right, because you were deep-sea fishing in the Keys, and now you're bass fishing. That's not bad. All right. Next career as a sushi chef. There you go. I love that. I love that.
46:58Well, everybody, thanks again for hanging out with us on the mail route. Thanks to iHeartRadio for making this all possible, and our sponsors, and Jordan Runta, above all, thanks for making it all sound slick, man. Have a good one. Dr. Mills, thanks for doing it with us. We love you.
47:20Let's talk about it. Let's talk about it.
47:43The Mailroom with Dr. Jesse Mills was a production of iHeartRadio. It was executive produced by Jordan Runtog. It was edited, mixed, and mastered by Bahid Frazier. And the theme was provided by Long Transit. If you liked what you heard, please subscribe and leave a review. For more podcasts from iHeartRadio, check out the iHeartRadio app, Apple Podcasts, or wherever you listen to your favorite shows. This program is intended for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Consult your health care provider for any medical or other related questions or concerns.
48:23The views and discussions aired on this podcast are those of Dr. Mills and do not represent the official positions of UCLA or UCLA Health.
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From the publisher
What happens when a man finishes too quickly — or struggles to finish at all? Dr. Jesse Mills explains why issues like premature ejaculation and delayed orgasm are more common than many men realize, and walks through the treatments that may help. He and Jordan also discuss unrealistic expectations shaped by porn, the internet phenomenon known as “death grip syndrome,” and why honest communication with a partner is often the best place to start.
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