In short
“The Mail Room” episode focused on men’s warning signs that shouldn’t be ignored—especially bleeding from any body opening, exertional chest pain, persistent lumps, blood in stool/urine/ejaculate, and “red flag” headaches/coughs.
Guests
Jesse Mills (host; urologist, “Male Reproductive Specialist”) and Jordan Runtog (co-host/executive producer). No outside medical guest appears in this transcript.
Key claims (examples included)
- Coughing up blood: needs evaluation (possible lung cancer, TB, ulcers/esophageal tears); chest X-ray/CT suggested.
- Shortness of breath: can signal heart failure or pneumonia.
- Vomiting blood: can be Mallory-Weiss tear or ulcers; not to dismiss after heavy drinking.
- Pissing blood: gross painless hematuria can indicate bladder cancer; persistent cases need urinalysis and cystoscopy.
- Blood in stool: don’t assume hemorrhoids; colon cancer in younger people is rising; colonoscopy recommended for unexplained blood.
- Blood in semen (hematospermia): usually not dangerous, but persistent/recurrent cases need evaluation; example of massive bleeding on a blood thinner after orgasm.
- Chest pain: exertional/persistent pain warrants urgent care; aortic aneurysm/dissection can present as back/shoulder-blade pain.
- Lumps: fixed/non-movable lumps or testicular/neck lumps should be checked promptly.
- Headaches: “thunderclap” onset, vision loss, photophobia, uncontrollable vomiting require urgent evaluation.
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VOWarning Signs Not to Ignore
0:41 to 2:03
Discussion on the importance of recognizing health warning signs.
“ZepBound Terzepatide may be able to help.”
Warning Signs Not to Ignore
3:50 to 4:39
Discussion on the importance of recognizing health warning signs.
“But again, this is going to be one of those like, even though it's just me and Jordan, no heavy, heavy stuff.”
Coughing Up Blood: What It Means
4:39 to 5:51
Exploration of the potential causes and seriousness of coughing up blood.
“And so I wanted to put together by no means an exhaustive list, but a thing if you're out there driving and listening to your podcast at work and thinking, oh, wow, that's me.”
Shortness of Breath and Its Implications
5:51 to 7:35
Discussion on shortness of breath as a symptom of serious health issues.
“of how much bleeding can we generate on one episode?”
Vomiting Blood: Causes and Risks
7:35 to 11:20
Analyzing the causes of vomiting blood and when it becomes serious.
“And so yeah, coughing of blood needs to be evaluated at least with a primary care visit, they'll at least get a chest x-ray.”
Understanding Hematuria: Blood in Urine
11:20 to 14:00
Discussion on the implications of hematuria and its potential causes.
“No, I can imagine that's never good either.”
The Risks of Vaping and Bladder Cancer
14:00 to 14:57
Learn about the health risks associated with vaping and its potential link to bladder cancer.
“The nicotine in it is bad for your heart, potentially bad for your lungs.”
Understanding Blood in Urine and Stool
14:58 to 15:30
Explore the significance of blood in urine and stool, and what it might indicate.
“They have so many carcinogens in them and they tend to concentrate in the bladder because that's where we store urine.”
Understanding Blood in Urine and Stool
17:01 to 17:19
Explore the significance of blood in urine and stool, and what it might indicate.
“The GeneSight test may reveal which mental health medications require dose adjustments, be less likely to work, or have an increased risk of side effects based on your DNA.”
Understanding Blood in Urine and Stool
17:28 to 18:49
Explore the significance of blood in urine and stool, and what it might indicate.
“ZepBound terzepatide may be able to help.”
Show all 28 chapters
Understanding Blood in Urine and Stool
19:42 to 19:57
Explore the significance of blood in urine and stool, and what it might indicate.
“Same day delivery for most internet eligible customers.”
Recognizing Serious Symptoms: Blood in Stool and Cancer Risks
20:08 to 21:11
Understand the serious implications of blood in stool and the increasing rates of colon cancer.
“I wish though for every Jordan, I mean like, you know, there are so many guys are like, ah, it's just hemorrhoids.”
Blood in Semen: What It Means
21:17 to 22:16
Learn about hematospermia, its causes, and when to seek medical advice.
“I mean, guys can have not cancer blood in the stool to the point where their hematocrit or their blood counts go down.”
Causes and Responses to Hematospermia
22:18 to 23:54
Explore the potential causes of blood in semen and the importance of evaluations.
“You've lived a good life so far, my friend.”
The Realities of Blood in Ejaculation
23:55 to 26:55
Gain insights into the nuances of bleeding associated with ejaculation and its implications.
“which just like a kidney stone causes blood in the urine, you can have stones or concretions that cause a tearing in the lining of the prostate that when you have an ejaculation, it causes blood.”
Heart Attack Warning Signs Every Man Should Know
26:56 to 28:00
Identify key warning signs of heart attacks and the importance of immediate response.
“So get it checked out, but not so worried about it.”
Understanding Chest Pain and Aortic Aneurysms
28:00 to 30:18
Learn about chest pain causes and the critical importance of recognizing aortic aneurysms.
“They may give you even something like morphine or a narcotic to help kind of relax things and keep the oxygen demand to the heart a little bit less.”
The Importance of Seeking Medical Attention
30:18 to 31:15
Discuss the significance of not ignoring symptoms like chest pain, even if they seem minor.
“And so again, these are all things that need to be evaluated because that is stuff you can't ignore.”
Lumps and Their Implications
31:15 to 33:19
Explore what different types of lumps indicate and when to seek medical care for them.
“And if you look at the number of chest pain diagnoses that are made in an emergency room that lead to, you know, immediate cardiac catheterization, you know, it's probably less than 10%.”
Lumps and Their Implications
33:33 to 33:56
Explore what different types of lumps indicate and when to seek medical care for them.
“Do you find yourself spending too much time on healthcare visits?”
Lumps and Their Implications
34:00 to 35:22
Explore what different types of lumps indicate and when to seek medical care for them.
“Are you looking for support in your weight management journey?”
Headaches: When to Worry
36:39 to 42:00
Identify headache types and know when to seek a doctor's advice.
“Like when we started this whole journey together, you and I, you know, you were 36 and you're like, I don't know when the last time I've been to a doctor.”
Understanding Headaches: Causes and Concerns
42:00 to 43:50
Learn about the significance of headaches and when to seek medical evaluation.
“And then also then just, yeah, the uncontrollable vomiting and headache.”
The Importance of Cough Evaluation
43:50 to 46:08
Discover when a persistent cough should be a cause for concern and the potential underlying issues.
“I mean, again, I'm a urologist, but certainly these are the things that come up to my list of what we shouldn't do.”
Medical Awareness: Listening to Your Body
46:08 to 47:00
Understand the importance of evaluating persistent symptoms rather than self-diagnosing.
“But yeah, I mean, you shouldn't just normally cough all the time.”
Inspirational Insights on Life and Health
47:00 to 48:44
Explore the profound messages about enjoying life and taking care of your health.
“I think, you know, and then even, you know, even as he sung on his way out, My Ride's Here.”
Inspirational Insights on Life and Health
49:54 to 51:32
Explore the profound messages about enjoying life and taking care of your health.
“The views and discussions aired on this podcast are those of Dr.”
Inspirational Insights on Life and Health
52:34 to 53:16
Explore the profound messages about enjoying life and taking care of your health.
“Same-day delivery for most internet-eligible customers.”
Transcript
Automatic transcript. May contain errors.0:00This is an iHeart Podcast. Guaranteed human. Let's be real. Eating is a huge part of our lives. It fuels us. It brings us together. And yes, it's one of life's great pleasures. But once a meal's over, we don't think much about what happens next. Unless something starts to feel off. Introducing Eating Interrupted, a new podcast from iHeartRuby Studio, hosted by longtime journalist and Crohn's patient, Cynthia McFadden. Listen in to unpack what it means when your body doesn't always respond to food the way you expect and what science is now revealing about why. Listen to Eating Interrupted on the iHeart app, Apple Podcasts, or wherever you get your podcasts.
0:40Are you looking for support in your weight management journey? ZepBound Terzepatide may be able to help. ZepBound is a prescription medicine used with a reduced calorie diet and increased physical activity to help adults with obesity. or some adults with overweight who also have weight-related medical problems to lose excess body weight and keep the weight off. ZepBound is approved as a 2.5, 5, 7.5, 10, 12.5, or 15 milligram injection. ZepBound contains terzepatide and should not be used with other terzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if ZepBound is safe and effective for use in children.
1:20Don't share needles or pens or reuse needles. Don't take if allergic to it, or if you or someone in your family had medullary thyroid cancer, or if you've had multiple endocrine neoplasia syndrome type 2. Tell your doctor if you get a lump or swelling in your neck. Stop ZepBound and call your doctor if you have severe stomach pain or a serious allergic reaction. Severe side effects may include inflamed pancreas or gallbladder problems. Tell your doctor if you experience vision changes before scheduled procedures with anesthesia. If you're nursing, pregnant, plan to be, or taking birth control pills.
1:51Taking ZepBound with a sulfonylurea or insulin may cause low blood sugar. Side effects include nausea, diarrhea, and vomiting, which can cause dehydration and worsen kidney problems. Talk to your doctor. Call 1-800-545-5979 or visit zepbounds.lily.com. Hey everyone, it's Kel Penn. I'm inviting you to join the best sounding book club you've ever heard with my podcast, Earsay, the Audible and iHeart Audiobook Club. Every episode, I nerd out with amazing guests and dive into the best new audiobooks available on Audible. It's the book club for your ears. Listen to Earsay, the Audible and iHeart Audiobook Club on the iHeartRadio app or wherever you get your podcasts.
2:41The washer won't start and the laundry's already piled to the ceiling. Hopping on grandappliance.com. Great idea. I heard they have next day delivery. Uh-huh, I'm seeing that too. And they have a bunch of GE options in stock. Oh, that's great. We've always had good luck with GE appliances. This one looks perfect. Scheduling for tomorrow. Gosh, Grand really makes it easy. Another crisis averted by the team at Grand Appliance. Visit GrandAppliance.com today. Grand Appliance, appliance experts since 1930. Let's talk about it. Let's talk about it in my room. Let's talk about it. Let's talk about it, the mailroom.
3:29Welcome to the mailroom. Hey, welcome back to the mailroom. I had to do a little Zeppelin. We're Beastie Boys, I guess, for that matter, right? Didn't they sample that at one point? I think so. Yeah, there you go. Welcome back, guys. Hey, Jesse Mills here with Jordan Runtah. As always, we're breaking it down, taking fact from fiction and figuring out how to make your lives a little better. Today, you know, we always have fun. But again, this is going to be one of those like, even though it's just me and Jordan, no heavy, heavy stuff. But this is going to be what will probably end up being generated as the stuff you can't ignore episode.
4:04And I think it came to my mind because we had a couple of summer, you know, very unexpected deaths in relatively healthy people. I won't go into the details, but, you know, pathology is anything from acute pneumonia to a ruptured aortic aneurysm. I mean, all kinds of horrible ways that guys can die. And this isn't like, could these have been prevented? Because who knows? I mean, I don't know the medical history necessarily of these guys. But it did get me thinking that there are things, the warning signs, that if we don't catch them soon enough, they can lead to really bad stuff. And so I wanted to put together by no means an exhaustive list, but a thing if you're out there driving and listening to your podcast at work and thinking, oh, wow, that's me.
4:48Then I want this to work as a PSA, public service announcement of stuff that you probably shouldn't ignore and get in to see your doc. And I wrote a chapter in my book a few years ago on this, too. So shameless plug for a field guide to men's health. But it does resonate today. These are universal things that have happened since humans have been humans that we really shouldn't say, you know, I'll deal with this next month, next year, you know, next decade. Are you up for it, Jordan? Absolutely. No, I think that as I reach my, as I lurch towards 40, I start to notice a lot of things I didn't notice before.
5:25And I often find myself wondering, you know, is this just what happens or is this something I should take a closer look at? So no, this is very good. This is very useful. I mean, there's headaches and then there's headaches. We'll talk about that. I got a bloody nose versus I'm coughing up blood. And so I think it's important. I got chest pain and I got heartburn. What's a different, right? So yeah, let's unpack it. I love starting with the Tarantino effect of how much bleeding can we generate on one episode? So we'll start with bleeding. you shouldn't ignore and go from there. So coughing up blood, is that, and this will be open forum, so chime in, but is coughing up blood ever like something you should ignore?
6:14I'll ask you the question. I'm going to answer your question by saying I didn't have my first bloody nose until I was 25 and I got so freaked out I fainted. So I would never ignore any blood coming out of any orifice, but that's just me. But I would say for coughing up blood, I'd say, I think I've only done it once. And that was after a really bad cold that bordered on bronchitis. And I was told it was more of a throat thing. But I would say you should not ignore that. Yeah. No, you're right. You shouldn't. And I'm glad you said I was told that. I'm hoping you were told that by a physician and not somebody that you were just on the subway next to who wasn't a physician and said, yeah, really the fact that you just coughed up blood all over me doesn't make me feel very good about sharing this metro with you right now.
7:04But yeah, no, coughing up blood is usually very bad. You know, it can be anything from lung cancer to tuberculosis, which is still around these days. So yeah, really bad bronchitis, really bad cold can even come from upper GI issues. So you can have ulcers in the esophagus or even tears in the esophagus that can get bad enough that it comes up as if it's either coming from the lungs or the abdomen or the elementary tract. So yeah, if it doesn't go away, especially that's something you really need to check out. But every time, you know, there's this dramatic movie scene, doesn't matter what it is, whether you're, you know, whether it's the tuberculosis has finally got us or whether the lung stage, the lung cancer has caught up to us or the metastatic cancer, you know, that's the sign that the hero is about ready to exit.
7:49And so yeah, coughing of blood needs to be evaluated at least with a primary care visit, they'll at least get a chest x-ray. but these days high resolution chest ct scans are are pretty cost-effective ways and especially if you have a history of cigarette smoking chemical exposures those are all things that are super important you know i you know i think about our coal miners still if you can believe it yeah things like black lung disease and mesothelioma are still out there you know and the safety mechanisms that we're supposedly have to have in in place for the collier's disease is not necessarily as good as it is.
8:24And so coughing up blood is always bad. I'll tell you on a side note, you know, the other thing that's really bad is something called silicosis, which is on the rise from all of these synthetic stone countertops that people are putting in their homes. And in fact, in the state of California, we're looking at potentially even banning those because we have all these young men coming in with what we call late stage pulmonary fibrosis because their lungs just start filling up with silica, which is this fine particular matter as you're grinding down your beautiful Cape Cod countertop that you're eating breakfast off of.
8:59Somebody's lungs are paying for that in the respiratory. The respiratory aspect of that, you know, putting on good masks isn't always followed. They're cumbersome. They're usually done in these hot, hot studios and workshops where it's almost impossible to breathe with a respirator on. You take it off, you can breathe, but then you're breathing in essentially shards of little glass that can cause pulmonary fibrosis. And so I will lead right into this, which is shortness of breath is another thing that if all of a sudden you can't finish a sentence because you can't quite get your air, not very good acting, I know, but that is also a really bad thing.
9:34So shortness of breath can be anything from heart failure to pneumonia, which is something that can come up even in young, healthy guys. And so that should be evaluated along with coughing up blood. So yeah, blood out of the chest or the belly, which leads us into vomiting blood, also really bad. You think, well, geez, I mean, of course it is. But it's amazing how often people will puke up blood for a little while before they think it's something that needs to be evaluated. If you got just absolutely plastered, blind-faced, drunk, you're supporting Spain in the World Cup, the only way that you know how.
10:10And yeah, you puke up a little blood and it goes away and it doesn't come back. probably just, you know, overindulged to the point where you may not need an evaluation for that. But it can actually be life-threatening from two reasons. One is you can have what we call a Mallory Weiss tear or an esophageal tear where you can so violently vomit that the esophagus rips and bleeds from the esophageal vessels to the point where you can need a blood transfusion. Same thing with stomach ulcers. I know they still happen, right? It happened to Springsteen a little while ago. I was surprised by that. But he had to cancel a few shows last summer.
10:46We have protein, what we call proton pump inhibitors or PPIs that can prevent the spread of stomach ulcers, usually from a bacteria called H. pylori. But again, even to people that have the best access to care, sometimes it can sneak up. And again, if you've got demands, you're working, and you just can't slow down, that can catch up to you. So really, vomiting blood, also bad, really never a sign of anything good. There can be incredible infectious diseases that, you know, that can cause puking up blood as well that you need to get worked out. So, yeah. So that's not good. What about pissing blood?
11:23Is that ever good? No, I can imagine that's never good either. Right answer. Yeah, you're winning this game. Yeah. I mean, pissing blood is often, it's probably just a bladder infection. I'll take some over-the-counter medications to make sure that it doesn't pee like glass when it comes out. And so there's two kinds of hematuria or blood in the urine. One is we call gross painless or GPH, gross painless hematuria. And then there's just dysuria, which means it hurts to pee and it feels like you're pissing glass. Usually, the more painful it is, it's a weird thing in medicine, but the more painful it is, usually the more of an acute, not life-threatening or cancerous process.
12:07that can be. And so if it really hurts to pee, and most likely it's a bladder infection that can cause the lining of the bladder to slough or to chafe, and then you have a little bit of blood in the urine, and it gets better on its own. But again, a urinary tract infection is not something you should try to treat at home. By the same token, if you see blood and you're urinating, then you need to get a urinalysis. You need to look for infection because if there is an infection and it's treated and it goes away, you're probably going to be okay. There it is. But if it persists, and unfortunately, the number of times that I've diagnosed bladder cancer in patients that were treated with antibiotics and it goes away and it comes back and it goes away and it comes back is nowhere near zero.
12:51In other words, that still should warrant a urologic evaluation where we look into the bladder with a tiny fiber optic or now digital scope called a cystoscope and see that the lining of the bladder is okay. And then there aren't things like bladder stones that can cause it, which can also cause urinary tract infections, as we talked about in a previous episode, or we can see bladder tumors. And bladder tumors are the early signs of bladder cancer, which if caught early can be like finding a little mole that you take off, never comes back. Great news. But again, skin is easier to check than the bladder.
13:28So even if you ever get a bladder tumor and it's even a low-grade cancer, you still need to come back to your urologist on an intermittent basis, depending on the severity of it, either every three months, six months, or yearly, to make sure that that tumor doesn't come up somewhere else. So yeah, gross painless hematology is usually associated with bladder cancer. That needs to be evaluated. Just like coughing up blood can be a sign of lung cancer, the most common cause of bladder cancer is cigarette smoking. It turns out smoking really is bad for you, Jordan. I know, shocker, stop the presses.
13:59We need to stop all sponsorship from big tobacco, of which, of course, we have zero. But yeah, not necessarily good for you. You're going to ask me about vaping. Don't know. Vaping, not good for you tobacco-wise. Still really bad. The nicotine in it is bad for your heart, potentially bad for your lungs. Haven't really had vaping around long enough to know if it has much of an effect on bladder. But I will say this, again, and this is out for all my firefighters and exposure, people out there that are in exposure areas, soldiers that are breathing in particulate matter, a lot of those things can be a trigger for early bladder cancer.
14:36So if I see a 35-year-old or even a 30-year-old firefighter and he's coming to me, say, for low testosterone, because that's also common in young guys that work shifts and work too hard, I'll still get a urinalysis on them because the risk of developing prostate cancer, bladder cancer from breathing in these horrific things that are in industrial fires can lead to both of those. They have so many carcinogens in them and they tend to concentrate in the bladder because that's where we store urine. Urine processes toxins. Those toxins eventually make it out of your body into the bladder. And if they sit there long enough, they can cause changes in the cellular anatomy, which can lead to bladder cancer.
15:15So yeah, pissing blood, not good. Or it could be a stone, right? And kidney stones, those are usually incredibly painful. And you will know if you have one most of the time. but for the most part, those are bad, you know? So yeah, good, good call on that. So pissing blood bad. What about, uh, what about the other kind of, uh, excretion? What about blood in the stool? Shitting blood? Is that good for you? Bad for you? Nothing to worry about? I would imagine that's, that's equally bad. That's my guess.
15:52let's be real eating is a huge part of our lives it fuels us it brings us together and yes it's one of life's great pleasures but once a meal's over we don't think much about what happens next unless something starts to feel off because what we eat and how our bodies respond to it is complicated. From the very first bite, food kicks off a chain reaction, signals moving between the gut, the brain, the immune system, a constant back and forth we can't see and often don't fully understand. Introducing Eating Interrupted, a new podcast from iHeartRuby Studio. Hosted by longtime journalist and Crohn's patient Cynthia McFadden, Eating Interrupted explores everything from food allergies and intolerances and why they seem to be on the rise to how digestion changes as we age and what it's really like to live with a chronic GI condition.
16:44Through personal stories and expert insight, listen in to unpack what it means when your body doesn't always respond to food the way you expect and what science is now revealing about why. Listen to Eating Interrupted on the iHeart app, Apple Podcasts, or wherever you get your podcasts. Struggling with side effects? your genes might tell you why. The GeneSight test may reveal which mental health medications require dose adjustments, be less likely to work, or have an increased risk of side effects based on your DNA. If your medications aren't working for you, discover how the GeneSight test may help.
17:19Visit genesight.com forward slash iHeart today. That's genesight.com forward slash iHeart today. Are you looking for support in your weight management journey? ZepBound terzepatide may be able to help. ZepBound is a prescription medicine used with a reduced calorie diet and increased physical activity to help adults with obesity or some adults with overweight who also have weight-related medical problems to lose excess body weight and keep the weight off. ZepBound is approved as a 2.5, 5, 7.5, 10, 12.5, or 15 milligram injection. ZepBound contains terzepatide and should not be used with other terzepatide-containing products or any GLP-1 receptor agonist medicines.
18:03It is not known if ZepBound is safe and effective for use in children. Don't share needles or pens or reuse needles. Don't take if allergic to it. Or if you or someone in your family had medullary thyroid cancer or if you've had multiple endocrine neoplasia syndrome type 2. Tell your doctor if you get a lump or swelling in your neck. Stop ZepBound and call your doctor if you have severe stomach pain or a serious allergic reaction. Severe side effects may include inflamed pancreas or gallbladder problems. Tell your doctor if you experience vision changes before scheduled procedures with anesthesia, if you're nursing, pregnant, plan to be, or taking birth control pills.
18:38Taking ZepBound with a sulfonylurea or insulin may cause low blood sugar. Side effects include nausea, diarrhea, and vomiting, which can cause dehydration and worsen kidney problems. Talk to your doctor. Call 1-800-545-5979 or visit zepbounce.lily.com.
19:01Zach, nice vacation spot, but without T-Mobile 5G home internet, I feel so cut off. It's scary. Relax, just breathe in the woodsy woodsy-ness. Zach! Don't open it! It's a monster! I just know it! Buddy, it's just our DoorDash driver delivering our T-Mobile 5G home internet. Here you go, guys. Thanks. Look, Donald, now you can get the fastest 5G home internet with same-day delivery powered by DoorDash. And it's easy to set up. See? Nothing to be afraid of. We're saved! It's scary how easy it is. Get T-Mobile 5G home internet delivered the same day. Powered by DoorDash. Just$35 a month with auto pay and a voice line.
19:46Plus taxes and fees. Same day delivery for most internet eligible customers. See if it's an option during checkout. Fastest according to UCLA speed test based on speed test intelligence data. Second half 2025. All rights reserved.
20:08You're winning. You're winning. I wish though for every Jordan, I mean like, you know, there are so many guys are like, ah, it's just hemorrhoids. and totally could be. Sure. A lot of guys will just say it's probably hemorrhoids. Unfortunately, you know, you get these news feeds or at least I do in health where like, ah, they told me it was just hemorrhoids and now I'm 40 and I have late stage cancer. So it does happen and we do know, and I believe we're going to have an expert on this in the next season, but we do know that colon cancer is on the rise in younger people and we don't know why yet.
20:41You know, it's probably environmental, probably linked to obesity, potentially linked to a change in our microbiome from antibiotic exposure when you're younger and you have a lot of ear infections, you take antibiotics, it can mess up the gut pathology. And then years later, it may lead to more of a pathologic bacterial microbiome that could be a precursor to cancer. We'll figure that out in another episode. But the bottom line is, don't just say it's hemorrhoids and you need to get it evaluated because of the incidence of colon cancer is on the upswing. And again, in general, if somebody younger, even than 40, comes in with blood in the stool, then the American GI or Gastroenterology Association, they looked at this about seven years ago, six years ago, and says they really should get a colonoscopy for all episodes of blood in the stool, not easily explained.
21:38And so that's important. And it can cause anemia. I mean, guys can have not cancer blood in the stool to the point where their hematocrit or their blood counts go down. They get lightheaded. They fall over. Their blood counts are so low, they need blood transfusions. And so, yeah, turns out crapping blood also not good. Yeah, easy enough. All right. I mean, what about blood in the semen? Hematospermia, ejaculating blood. Is that good, bad, or not a big deal? I'm just going to give a blanket blood in any orifice unless it's maybe the nose, probably not good. But so yeah, I'm going to guess. I've never heard of blood in the semen.
22:16That's a new one to me. And that sounds like a fresh hell that I don't want any part of. You've lived a good life so far, my friend. Yeah. Actually, the answer is that hematospermia is almost always not bad. So I threw a trick one at you. Okay. All right. It's kind of like a nosebleed. So why do nosebleeds happen? because the mucosal lining of the nose sometimes gets irritated. It's really dry out. You sneeze really hard. You cause a lot of pressure. It ruptures a vessel up in the turbinates or some part of the nose that is very easily bloodied. And you get a nosebleed. Well, actually, it turns out the same thing happens most often in the prostatic mucosa in the urinary system where sometimes an incredibly forceful ejaculation can cause blood in the urine.
23:06It turns bright red and it can take a week or two or three weeks to clear. And what will usually happen is a guy has a forceful ejaculation, ejaculates blood, and then it gets rusty and then it gets better. And most of the time, it doesn't need an extensive workup. You got to rule out things like prostate cancer. In 20, almost 30 years now of being a physician, I've not ever once diagnosed prostate cancer from blood in the semen, but I make sure the guy gets the evaluation he needs to rule that out. Sometimes, just like if you get recurrent nosebleeds, you're going to need an endoscopy of the nose to see if there's some ulcer up there or some, you know, God forbid, sometimes you can get nasal cancers that can lead to bloody noses.
23:46So persistent nosebleeds do need to be evaluated. Just like if the hematospermia, the blood in the ejaculate doesn't go away, we need to check out too. You can, believe it or not, have stones in the ejaculatory duct, which just like a kidney stone causes blood in the urine, you can have stones or concretions that cause a tearing in the lining of the prostate that when you have an ejaculation, it causes blood. But almost always is not dangerous. Still need to have it checked out. Still need to make sure nothing else is going on. But it's not like you have to run to the ER the first time you see blood in the semen.
24:17But the most common cause is you haven't had an orgasm in a long time and you just have this amazing release and that can grip those little vessels in the prostate and lead to hematospermia. I'll tell you a story of a guy years ago that I took care of who was in his 80s. And he had had a prostate procedure a long time ago called a TURP or a transurethral resection of the prostate where we shave out the inner lining of the prostate so that guys can pee better. And we'll have a whole episode on that too coming up. And he was peeing great, but as he got older, he realized that he was unable to have an orgasm, which is we've talked about before.
24:56Anorgasm is a real problem. It's frustrating if a guy gets great erections, able to have intercourse, but can never get to that finish or that payoff, it can be vexing. And there's an off-label use that we've talked about in previous episodes. There's a medication called Kerbergoline, which can help lower that neurologic and neurohormonal threshold so that some guys that can't orgasm can finally have an orgasm again. And so this guy, it is 80s, very healthy, very active guy, still very fit, has a great relationship with his partner. And I just want to orgasm, Doc. This is crazy. It's been all these years.
25:35He also had a little bit of heart issues. So he's on a blood thinner. And so he, you know, easily bruised, you know, and every time he, he really did any activity that, you know, that would, a shaving cut would bleed a little bit longer, that kind of stuff. And he, he said, Doc, I do something for me. And so I gave him cobergoline and went home. And then a couple days later, I get a call that my patient is in the hospital with massive bleeding coming from his penis. And I went in and saw him. He was in another urologist taking care of him, but I kind of made a courtesy visit. I said, what happened?
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26:15He said, well, you know, I finally had that orgasm. So he literally had bleeding to the point from hematoptermia because he was on a blood thinner that it just let it rip. that prostate vessel ruptured because you not had a strong orgasm in years. And he looked at me and said, Doc, I'm not mad. It was worth it. So, you know, thankfully we were able to control it with a little cautery. But, yeah, I mean, that is the nut of all nuts, right? I mean, you just end up in a hospital with blood that you can't stop. So, yeah, so, again, most of the time ejaculating blood, not good, but still can be pathological, especially if you have any kind of bleeding disorders.
26:57So get it checked out, but not so worried about it. So anyway, those are the blood things you can't ignore. What about like heart attack stuff? Things that are things. I mean, things that are issues like we know that you should call 911. You have substernal chest pain, radiating down to the arm. Most guys know that they really shouldn't ignore that. It's amazing how many still do. But what are the things that you should look for is what we call exertional chest pain. So in other words, if you're just sitting at your laptop and you get a little catch, you know, and you kind of adjust and it goes away and it doesn't come back, you know, then that's probably not a heart attack.
27:37Not as big a deal. But if, you know, if you're walking up a flight of stairs, if you suddenly get some stressful news that you clutch your chest, then that's exertional chest pain. And that needs to be worked on right away. If you have an aspirin handy, then you can chew on it because that's the first thing they're going to do when they get to the emergency room or when your paramedics come actually is they're going to give you oxygen. They're going to give you aspirin. They may give you even something like morphine or a narcotic to help kind of relax things and keep the oxygen demand to the heart a little bit less.
28:12Because basically what happens is your blood flow to the heart is not able to keep up with the exertion that you're performing. And that's what can lead to a heart attack. So you've got to slow down that with a little bit of Astro. and then again, if you've had a history of it, then everybody knows that you have a little nitroglycerin pill that you can take and that will immediately open up the blood vessel as much as you can until you get emergency care. But those are kind of the early warning signs of chest pain. But the heart is not the only thing that can cause chest pain, the aorta can too.
28:45And so if we worry about things like an aortic aneurysm or a dissecting aortic aneurysm, which again, will kill you very quickly, that tends to be more, if it's up in the upper aorta, it tends to be more in the back. You'll feel it between your shoulder blades. And any kind of boring, grinding pain that is getting progressively worse between your shoulder blades, that is what we call a dissecting aortic aneurysm until you know better. So you need to go to the emergency room right away. If it's down in the belly, you get just incredible acute onset belly pain, then we got to worry about that too.
29:20And again, that could be from a GI source. He just had food poisoning. But again, if it's this grinding, grinding pain, that can be a real sign of something bad. I'll tell you the story that came up recently that I was tangentially involved with as a young guy who had what we call a mycotic aneurysm, which is where he had a fungal infection. This came from eating. He was out of the country and he ate undercooked lamb and the lamb had something called brucellosis in it. And that can set up a fungal aneurysm where the fungus can get into the wall, the lining of an artery, and eventually erode it and then cause a dissecting abdominal aortic aneurysm as well.
30:00And again, he really didn't want to get treated. He wanted to catch a flight. But thankfully, one of my astute vascular surgeon colleagues in the ER said, no, this is going to kill you if you don't get operated on immediately. So aortic aneurysms can happen in young guys. IV drug users, male and female, can get fungal aneurysms from dirty needles. And so again, these are all things that need to be evaluated because that is stuff you can't ignore. So I laid a bunch on you there. I want you to catch up with your questions and signs of horror. You still have all your color in your face. So that's good news.
30:34I mean, chest pain, that's the scariest thing to me because I feel like the spectrum, I am not able to really tell the difference because to me, chest pain is chest pain, But the spectrum of really not being a big deal to being a huge deal is so broad. Blood coming from an orifice, that I can understand and generally understand is something you should get checked out. But chest pain, that's the thing that I think scares me more than any symptom that seems like something that you could very easily ignore. Because you're right. It could be indigestion. It could be anxiety. It could be a pulled muscle.
31:09It's so easy to dismiss it as nothing. Yeah. And I think that's important is the persistence of it. And if you look at the number of chest pain diagnoses that are made in an emergency room that lead to, you know, immediate cardiac catheterization, you know, it's probably less than 10%. But those are the lives you're saving. Yeah. You still have to do the workup, which is usually pretty easy to do. But, yeah, it's usually the chest pain that doesn't go away, you know, in just a couple seconds that is still there and persistent that you can't ignore. So, yeah, I mean, it's tricky. You know, the human body is amazing.
31:45It heals itself pretty well, but every once in a while it can't. That's what we're here for as doctors. What about lumps? Like, you know, if you had a new lump that just developed in your neck, in your testicle, in your arm, like, are those things that you should ignore or are those things that you should, you know, seek a relatively immediate care for? I usually, just because of family history, go to a dermatologist as soon as I can or a primary care physician.
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34:35It is not known if ZepBound is safe and effective for use in children. Don't share needles or pens or reuse needles. Don't take if allergic to it. Or if you or someone in your family had medullary thyroid cancer, or if you've had multiple endocrine neoplasia syndrome type 2, tell your doctor if you get a lump or swelling in your neck. Stop ZepBound and call your doctor if you have severe stomach pain or a serious allergic reaction. Severe side effects may include inflamed pancreas or gallbladder problems. Tell your doctor if you experience vision changes before scheduled procedures with anesthesia, if you're nursing, pregnant, plan-to-be, or taking birth control pills.
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36:36Yeah, yeah, right. Good for you. I mean, you are, you know, you're amazing. Like when we started this whole journey together, you and I, you know, you were 36 and you're like, I don't know when the last time I've been to a doctor. And now, I mean, you're just a wealth of anxiety. That's right. Well, if I've only helped one person in my entire mission on air, it's Jordan Runtog, everybody. But yeah, lumps tend to be bad. There you go. Lumps tend to be bad, but there is a way, especially if you get something not within an organ, like if it's in the testicle, always need to get evaluated. If it's in the neck and it doesn't go away, if you have a sore throat, for example, and you have a little lump in your neck and it gets better with an antibiotic, then you just add a swollen lymph node.
37:19And especially if it's tender, but if it stays around for more than a week and if it doesn't move, if you grab it, And again, you can have a lump on your arm, on your knee, and the majority of them are benign and often what we call lipomas. But if they're fixed, in other words, if you can pick up this little rubbery nodule and you can squish it back and forth in your arm, you still get it checked out and certainly removed, especially if it bugs you. But if it doesn't move, if it's there and it's like this little claw that doesn't want to move, then that's something that needs to be checked out because there's a lot of different kinds of bad tumors that can generate from lumps on the body, whether it's on the abdominal wall, whether it's on your back between your shoulder blades and your shoulders, arms.
38:02There are all kinds of things. Usually it affects younger people, but not always. And so again, get it checked out. Lumps are bad. Tell me about headaches. You know, when should you see a doctor? Yeah, talk to me about that. I mean, we all get headaches, right? I get headaches a lot because sometimes I'm poorly hydrated. I'm often stressed, bad, bad posture. So many, you know, looking at a screen too much and I don't have those glasses that are supposed to be better. So there's a lot of I get headaches a lot for a lot of reasons that I always honestly chalked up to. This is my one thing that I do tend to ignore my headaches.
38:42I get a lot of headaches. um but i i mean let me ask you how when does that cross the line into being uh other than maybe seeing an optometrist for reading classes when does that cross the line into something that i should check out um with a position yeah well you said something very important you you know you don't ignore them you know you say oh i'm dehydrated what do you do you drink and and and a headache goes away then you solved your own problem same thing it's like oh well there okay Okay, well, yeah, and Excedrin actually, you know, it's a fantastic headache cure because it also, in addition to the acetaminophen or Tylenol it has in it, it does have a little bit of caffeine.
39:22And so if you already have a little bit of a caffeine habit, then yeah, I mean, sadly, I, you know, I will open up to the world that my only true addiction, which again, isn't really an addiction, but my true dependency is caffeine. I mean, I love my coffee that, yeah, if I, you know, if I don't drink my cup of coffee in the morning, which is a never event, but if I don't say, yeah, somewhere around noon, I'll start to get a headache and say, oh yeah, that's right. I didn't have my coffee. So, you know, it's not going to kill me. And I know why. And if I said, dang it, I got to stop drinking coffee because, you know, people are telling me it's bad for you, which you'll never hear from me, even though I'm a doctor, a voice among the din.
39:58but um but the bottom line is that you know caffeine withdrawal excedrin will cure right why because it has caffeine in it so it's a little hair of the dog so yeah that's why excedrin it works but but so right if you're pounding it though and you and that's a really good point because if you're if your treatment for any headache you get is to take acetaminophen or or ibuprofen which is advil motrin those kinds of nseds or caffeine and you keep getting it the same day, same time, and you're not getting that, that actually should be evaluated. So you shouldn't have to take Tylenol every day of your life without a diagnosis of why you're getting those headaches.
40:36So that is a sort of a relative warning sign. But right, if you get a headache and you drink a glass of water and it goes away, or if you shut your damn computer down for a little bit and you go out and walk along the beach or take a walk in your neighborhood and reconnect, take some deep breaths and it goes away, great. Then that was a lifestyle-induced headache and you know that you shouldn't be on your screen 12 hours a day. If you get a thunderclap onset, they literally, that's a term, a thunderclap headache, where it's just pow, you know, comes out of nowhere. You see stars, you lose vision for a little, even a second or two.
41:09Those are really bad headaches. And you have to get those immediately evaluated because they're never good. And sometimes they are, you know, can be attributed to just acute vascular headaches that are not dangerous. But The problem is sometimes headaches can be from an intracranial bleed. A subarachnoid hemorrhage is kind of the classic one that you can get that then can lead to a stroke and that can then lead to death or intracranial pressure elevations. And so thunderclap, those you have to be evaluated, even reasonable to go to the emergency room for those. If you have a loss of vision, a lot of things can cause that from brain tumors to vascular strokes as well to the thalamic nerve.
41:49And so those need to be evaluated right away. If you have what we call photophobia or incredible light sensitivity where you can't see it, it could be a migraine, which are not benign, but they're also not going to kill you. But if you don't have a diagnosis of migraine headaches and they haven't done the head CT scan or the functional MRI or some kind of mediated MRI where they're looking with a contrast to make sure you don't have some kind of aneurysmic malformation, then you need to get you need to get evaluated for that and if you like look dude at the end of the day you just get bad migraines there's great treatment for that but and i'm sure actually this kind of says we need an episode on headaches and bring in a true headache specialist because we really can unpack a lot of stuff and it is such a common thing maybe it's more common these days because of screen use and uh and chronic dehydration and all the other things but but But yeah, we really have to bring an expert for that in.
42:44So yeah, foreshadowing. And then also then just, yeah, the uncontrollable vomiting and headache. Those are the things we worry about. You hear about things like meningitis, which can go through summer camps and college dormitories and military barracks when everybody gets together in a tight space. Those are also really bad. So yeah, in general, the only headache, well, actually you should ignore none. But can you self-treat? Yeah. You know, if you do something simple and it goes away, then you're probably going to be okay. But yeah, but headaches, they really, it's an amazing, the amount of work loss that happens on an institutional level with headaches.
43:20It's amazing the amount of pain and suffering and sleep deprivation. People that I can't exercise, I can't get out of bed. And so it is, if not a epidemic, at least it's a public health concern, both from the workplace and how much work we're able to get done. and lifestyle. I mean, if you live with somebody that has chronic headaches and they're grumpy all the time and you do your best to support them, that's tough. That could take a real caretaker toll. So, yeah, headaches are bad too. That's all I got for you, things that I worry about. I mean, again, I'm a urologist, but certainly these are the things that come up to my list of what we shouldn't do.
43:55What do you got for me that you're like, oh, Mills, you forgot this i mean like you know i've won uh i'm a big fan of uh warren zivon and i i love his interview that he gave with uh with david letterman shortly before his death which is really for i recommend to anyone really his line of you know enjoy every sandwich like basically advice from a man who's dying about how to enjoy life but he talks about how he first discovered he was diagnosed with lung cancer and he just had a chronic cough that he thought was a cold that wouldn't go away and that always haunted me and now every time you know if i've i have a cough that goes on for more than a week and a half i start to panic and thinking of you know my caudal cancer um yes i wanted to talk to you about when to get a cough checked out because it's you know summer cold season and all that kind of stuff right and then we're going to be going in the allergy season and in the fall and yeah i just want to ask you about right yeah i mean i would say that it is anytime that it doesn't go away, you know, after a solid week or two, and you don't have an explanation.
44:58So, you know, you have allergies, you have, you know, kind of post-nasal drip, all those things that you can't obviously explain away, then you definitely get checked out. If you have risk factors, like you live in an area that has a lot of fungal infections, a lot of agriculture areas, especially in the Central Valley here in California, we know something called valley fever, which is an endemic issue, especially for farm workers, people that live close to the soil. That can cause the, I mean, God, we just had the hantavirus epidemic in the cruise ship. And those, you know, we used to think those were pretty much isolated to sort of high desert regions in Southern Colorado, Northern New Mexico.
45:41California is starting to see it a little bit more. But again, these are rodent-borne illnesses that can start off, you know, with just a cough. And then usually it's associated with the fever. So you need to get that checked out. And again, coughing up blood at any time is bad. But yeah, even if you have a dry hacking cough that doesn't go away after a week or two, reasonable to get checked out. You know, a chest x-ray is an easy thing to start with and let your doc kind of figure out how to do the workup from there. But yeah, I mean, you shouldn't just normally cough all the time. Well said.
46:14Right? Yeah. I mean, you know, common sense mixed with a little bit of medical knowledge. That's how we roll around here. That's what we do. But yeah, I mean, I think, you know, the take home too is, you know, if anything just doesn't seem right to you that has always been right your whole life and is not getting easily corrected, you should get it evaluated. You know, you shouldn't just kind of Google it away or AI it away. There could be a source and could be easily treatable, especially if it's just annoying to you, like a chronic cough. But eventually, you know, you got to see somebody for that.
46:47You'll have a medical expert tell you you're probably going to be okay or you'll catch something, you know, as early as you can and take care of it. So either way, it's a win-win. Well, and also, you know, and make sure that you're enjoying every sandwich along the way. Yes. And I think that's true. And I quote him often. I think, you know, and then even, you know, even as he sung on his way out, My Ride's Here. I mean, that's such a brilliant song that once you watch the David Letterman, just listen to him and then listen to Springsteen do my rides here. When he announced live in concert, he just heard about Warren's death and he did it live.
47:21If that doesn't bring tears to your eyes, then, you know, you have no feeling. I'm just telling you that it is the most beautiful homage, not to mention him doing Knocking on Heaven's Door. Oh, the winds. Yeah, taking Dylan's song. And wow, I mean, between that and Axl Rose's version, you can just do a whole playlist on that. Yeah, we need to get DJ Hesta back in here and say, give me a good death playlist about what I want to hear. But my rides here has definitely got to be at the top of that. Right on, I second that. Dude, too much. That was sort of an inspiring, invigorating way to say, hey, stay alive as long as you can.
48:03Enjoy it while you can, which is what I'm going to tell you right now is that, man, you got to get out of here. Have a great day. Get out, walk the beach, get just enough sun so that you get some vitamin D exposure, but not enough to develop melanoma. I don't know what that threshold is, man. But, you know, put a little SPF on and, you know, enjoy yourself, brother. It's doctor's orders. You got it, my friend. All right, dude, so much fun. Thanks for hanging out with me again. Thanks to the listeners for tuning in to yet another enthralling episode of the Male Reproductive Specialist talking about all things health and wellness.
48:37Too much fun. And we'll see you next time. Long Transit, thanks. iHeartRadio, double thanks. Thanks.
49:14The Mail Room with Dr. Jesse Mills was a production of iHeartRadio. It was executive produced by Jordan Runtog. It was edited, mixed, and mastered by Bahid Frazier. And the theme was provided by Long Transit. If you like what you heard, please subscribe and leave a review. For more podcasts from iHeartRadio, check out the iHeartRadio app, Apple Podcasts, or wherever you listen to your favorite shows. This program is intended for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Consult your health care provider for any medical or other related questions or concerns.
49:54The views and discussions aired on this podcast are those of Dr. Mills and do not represent the official positions of UCLA or UCLA Health.
50:24some adults with overweight who also have weight-related medical problems to lose excess body weight and keep the weight off. ZepBound is approved as a 2.5, 5, 7.5, 10, 12.5, or 15 milligram injection. ZepBound contains terzepatide and should not be used with other terzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if ZepBound is safe and effective for use in children. Don't share needles or pens or reuse needles. Don't take if allergic to it, or if you or someone in your family had medullary thyroid cancer or if you've had multiple endocrine neoplasia syndrome type 2.
51:00Tell your doctor if you get a lump or swelling in your neck. Stop ZepBound and call your doctor if you have severe stomach pain or a serious allergic reaction. Severe side effects may include inflamed pancreas or gallbladder problems. Tell your doctor if you experience vision changes before scheduled procedures with anesthesia. If you're nursing, pregnant, plan to be or taking birth control pills. Taking ZepBound with a sulfonylurea or insulin may cause low blood sugar. Side effects include nausea, diarrhea, and vomiting, which can cause dehydration and worsen kidney problems. Talk to your doctor.
51:32Call 1-800-545-5979 or visit zepbounds.lily.com. Ugh, the washer won't start and the laundry's already piled to the ceiling. Hopping on grandappliance.com. Great idea. I heard they have next day delivery. Uh-huh, I'm seeing that too. And they have a bunch of GE options in stock. Oh, that's great. We've always had good luck with GE appliances. This one looks perfect. Scheduling for tomorrow. Gosh, Grand really makes it easy. Another crisis averted by the team at Grand Appliance. Visit GrandAppliance.com today. Grand Appliance, appliance experts since 1930. Zach, nice vacation spot, but without T-Mobile 5G home internet, it's scary here.
52:20Don't open it. Relax. I ordered T-Mobile 5G home internet with same-day delivery powered by DoorDash. Nothing to be afraid of. We're saved. Get T-Mobile 5G home internet delivered the same day. Powered by DoorDash. Just$35 a month with auto pay and a voice line. Plus taxes and fees. Same-day delivery for most internet-eligible customers. See if it's an option during checkout. There are exciting things happening at your local CVS. shop new extra big deals with extra care every two weeks no coupon needed plus get access to exclusive sale prices personalized deals and more as a member extra care is the way to save at cvs join for free online or in store and start saving visit your local cvs store or cvs.com extra big deals for this week's deals this is an iheart podcast guaranteed human Thank you.
From the publisher
When is a strange symptom just part of getting older—and when is it a warning sign you should never ignore? Dr. Mills breaks down the red flags that warrant medical attention, including unexplained bleeding, persistent chest pain, sudden severe headaches, new lumps, shortness of breath, and a cough that won’t go away. He also explains why some frightening symptoms may be less dangerous than they appear, while seemingly minor changes can signal something serious.
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