The Surprising Truth About Longevity Medicine – with Dr. Darshan Shah

7 Jul 2025 · 1 h 10 min · 26 chapters

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In short

Longevity medicine reframed as adding healthspan (productive years) and preventing preventable deaths (heart attack, Alzheimer’s, cancer, metabolic disease). Dr. Shah argues longevity isn’t “biohacking,” but a 4-pillar approach: lifestyle medicine (sleep, exercise, nutrition), functional medicine (root causes like gut/hormonal health), preventative medicine (earlier intervention using advanced diagnostics), and longevity medicine (regenerative/biohacking tools like stem cells, exosomes, peptides, hyperbaric oxygen, LED/photobiomodulation). He emphasizes using technology earlier, especially biomarkers and imaging.

Guest

Dr. Darshan Shah, MD. Board-certified surgeon, published author, founder of NextHealth (health optimization/longevity clinic). Trained at accelerated MD program and Mayo Clinic; functional medicine training. Named Longevity Doctor of the Year by Longevity Doctors Association; nominated for Functional Medicine Innovator of the Year (Athletec).

Key claims & notable examples

Coffee (with quality control) associated with lower all-cause and cardiovascular/cancer mortality; chaga may support natural killer cells and antioxidant enzymes. NAD (NR/Niagen, NMN, NAD+ forms) supports cellular energy; nicotine pouches can enhance cognition/performance but cigarettes are harmful due to respiratory/cancer risk. “Clearly Scan” (AI-assisted coronary plaque imaging) can reveal dangerous plaque beyond cholesterol numbers; plaque formation linked to endothelial damage, inflammation, metabolic health, and hypertension. Surprising bloodwork: A1c optimal target ~5.2 or below, testosterone often low, HS-CRP ideally near zero; fasting insulin as early metabolic marker. Stress management: cortisol rises after ~20–30 minutes; use 30-minute breaks (egg-timer) to reset. Social connection: chronic loneliness increases mortality risk; Jeffersonian dinner format (one person speaks at a time) to deepen relationships.

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

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The Importance of Longevity Knowledge

0:45 to 1:09

Discussion on the significance of learning from experts in longevity.

“Some emerging supplements and some of the science behind it.”

Impactful Beverages on Longevity

1:09 to 1:53

Exploration of longevity-related beverages, particularly coffee.

“And it's just a matter of like, where are we investing our attention?”

The Science Behind Coffee and Longevity

1:53 to 3:51

Evidence linking coffee consumption to a lower risk of death and improved health.

“Now, before we get to our special guest, any conversation about longevity deserves a conversation about some of the most revered longevity beverages that humans have been consuming for centuries.”

Chaga and Medicinal Mushrooms in Coffee

3:51 to 5:36

Benefits of combining coffee with medicinal mushrooms for health.

“researchers at Stanford University deduced that a part of this connection to longevity when it comes to coffee is that coffee has these compounds that have been found to defend our body against age-related inflammation.”

Introducing Dr. Darshan Shah

6:49 to 8:06

Introduction of Dr. Shah and his credentials in longevity medicine.

“That's F O U R S I G M A T I C.com forward slash model.”

Understanding Longevity and Healthspan

8:06 to 11:30

Dr. Shah discusses the true meaning of longevity and healthspan.

“It's so good to have a friend here and to hang out.”

Current Trends in Chronic Disease Management

11:30 to 13:46

Discussion on reversing the trend of chronic diseases and future expectations.

“that we just take it for granted that this is what we're gonna die of.”

Technologies Supporting Longevity

13:46 to 14:00

Overview of technologies and treatments used for longevity at Dr. Shah's clinic.

“So question, and I want to steer this towards, you've mentioned technology a couple of times.”

Understanding Longevity Medicine

14:00 to 18:11

Explore the pillars of longevity medicine and their importance.

“So what I would say is maybe I can take it a step back a little bit.”

The Importance of Inputs for Health

18:11 to 19:18

Learn why foundational health inputs are critical before biohacking.

“Because, you know, we have colleagues that get obsessed with that fourth pillar.”
Show all 26 chapters

NAD and Its Role in Energy

19:18 to 23:00

Discover the significance of NAD for energy production in cells.

“But I don't want anyone getting into a hyperbaric chamber until they've talked to me about all this other stuff first.”

The Emergence of Nicotine in Longevity

23:00 to 24:59

Understand the cognitive benefits and risks of nicotine use.

“So you mentioned a nicotinamide version, which got me thinking about this category of nicotine.”

Detecting Heart Disease Early

24:59 to 28:00

Learn about advancements in heart disease detection and prevention.

“Well, going back to one of the hallmarks of longevity, which is not dying.”

Understanding Arterial Plaque Formation

28:00 to 30:20

Learn about the causes of plaque buildup in arteries and its implications for health.

“So the reason people get plaque is three reasons.”

The Importance of Comprehensive Blood Work

30:20 to 31:50

Discover why comprehensive blood tests are crucial for understanding your health.

“Now all of these factors and being able to deep dive and do more comprehensive tests are now available, right?”

Empowering Health Through Technology

33:10 to 35:34

Explore how technology can help individuals take charge of their health.

“And so I think it's so important for people to start doing it now because we've outsourced our health to, you know, who we thought was taking care of it for.”

Common Surprises in Blood Test Results

35:34 to 37:14

Learn about three surprising blood markers that affect longevity.

“who's a part of this conversation, they're proactively listening and learning to something to empower them.”

The Role of Stress in Health

37:14 to 41:46

Understand how psychological stress can impact physiological health.

“Your body works and the learning is just so self-sustaining too, right?”

Physiological Effects of Stress

41:46 to 42:01

Explore the connection between mental stress and health outcomes.

“So on my website, drshah.com slash biomarkers, there's a list of all the biomarkers.”

The Impact of Stress on Longevity

42:01 to 49:06

Learn about how psychological stress affects physical health and longevity.

“kind of insidious and even hidden in a way is stress.”

Social Connections and Longevity

49:06 to 56:04

Discover the crucial role of social relationships in promoting longevity.

“And, you know, this is one of them that's not so obvious is social isolation and community is a major pillar of health.”

The Importance of Microbial Diversity

56:04 to 57:55

Learn about the significance of microbial diversity in our diets and health.

“There's this one called Acromantia, which is a keystone bacteria that helps us make GOP-1.”

Increasing Plant Diversity in Diet

57:55 to 1:00:16

Discover practical ways to increase plant diversity in your meals for better health.

“So I just think just having a thought in your brain that every plate of food you eat should have some vegetables in it.”

NextHealth and Longevity Medicine

1:00:16 to 1:01:14

Explore the new advancements in longevity medicine and health optimization.

“And so I really feel like we're creating a new system of health care.”

NextHealth and Longevity Medicine

1:01:17 to 1:02:19

Explore the new advancements in longevity medicine and health optimization.

“Right now we're LA, we're New York, we are going to be in Newport Beach, Chicago, we're Nashville as well, Montecito, Santa Barbara area, but we're going to be everywhere in the next few months.”

Wrap-Up and Insights

1:06:06 to 1:07:25

Reflect on key takeaways from the episode and future content.

“It is absolutely amazing, all the value that you get through Levels.”
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Transcript

Automatic transcript. May contain errors.

0:00Shawn Stevenson:You are now listening to The Model Health Show with Shawn Stevenson. For more, visit themodelhealthshow.com.

0:11Shawn Stevenson:What are the latest innovations in longevity? Well, today you're going to hear from the person who was just awarded the Longevity Doctor of the Year by the prestigious Longevity Doctors Association. If anyone knows about the science of longevity, it is our special guest today. And I'm telling you, we're going to dive into a bunch of different subject matters. He's going to talk about these four important pillars when he's working with his patients. And also he's going to be talking about some of the things that we might not know about yet, right? Some emerging supplements and some of the science behind it.

0:49And some things were pretty surprising for me and we haven't really talked about before.

0:53Shawn Stevenson:And so all of this in this rich conversation, but this is one of the blessings of having access to information like this today right at our fingertips is that we get to learn from the very best people in the world in their respective fields. And it's just amazing. And it's just a matter of like, where are we investing our attention? And so I'm so grateful for you being here and choosing to be here with me today and to share in this knowledge. And of course, not just us taking this in ourselves, but being able to express this by the way that we live our lives and to share it with the people that we care about.

1:29Shawn Stevenson:This is important now more than ever to be a model and to also be a giver and a person being of service to help to uplift the people around us. Again, we need this now more than ever. So again, today we're going to be talking about the emerging field of longevity medicine, supplements to keep an eye out for, blood tests, and so much more. Very, very excited about today's episode. Now, before we get to our special guest, any conversation about longevity deserves a conversation about some of the most revered longevity beverages that humans have been consuming for centuries. and one of the most revered, one of the most favorited.

2:14Shawn Stevenson:It would be hearted if it had the ability to push a button in real life when people are having their cup of coffee. Now, if you're like me, growing up, I thought that coffee was the complete opposite of anything healthful. I thought that it was problematic. I thought that my grandparents were super weird for drinking it because taking a little sip as a kid, I thought it was gross. and little did I know that, of course, like the Folgers in your cup, whatever version of coffee that my grandparents were drinking, that was not the good stuff. All right. It was littered with all manner of pesticides and herbicides and, you know, chemical contaminants, probably mold, the list goes on and on.

2:57Shawn Stevenson:But high quality coffee is actually, according to the data, one of the most healthful drinks when it comes to extending your lifespan than just about anything that's been studied. A meta-analysis of 40 studies published in the European Journal of Epidemiology revealed that regularly drinking coffee was associated with a lower risk of death from cardiovascular disease, certain types of cancer, and all-cause mortality. Now, although this was a notable association, the researchers adjusted for a variety of confounding factors, including age, obesity, alcohol consumption, smoking, and still found that drinking coffee stood out as a significant defense against all cause mortality.

3:47Shawn Stevenson:It is a strong element of longevity. Now, some researchers at Stanford University deduced that a part of this connection to longevity when it comes to coffee is that coffee has these compounds that have been found to defend our body against age-related inflammation. But once more, the quality is important. It is extremely important. The best part of waking up Folgers in Your Cup paradigm is over. All right. We're really being mindful of the quality of coffee. And also something that I don't talk about quite enough is utilizing incredible organic coffee, yes, but coffee that is infused with science-backed medicinal mushrooms like chaga.

4:32Shawn Stevenson:I don't talk about chaga enough. Chaga is one of the most researched and has some of the highest amounts of published data affirming its benefits. Studies indicate that chaga can significantly increase the activity and effectiveness of our natural killer cells. So these are immune cells that are able to be essentially trained to help to modulate, right? So immunomodulation, ramp our immune system up if need be, or help it to down-regulate its activity and its function if we're talking about in the case of a potential autoimmune condition where the immune system is overactive. Chaga is also one of the richest sources of antioxidants utilized by humans, and it's been shown to increase our body's levels of something called superoxide dismutase.

5:20Shawn Stevenson:And this is an antioxidant enzyme within our bodies that plays a significant role as a free radical scavenger. It essentially acts as a bodyguard that protects your DNA from damage and helps to reduce the workload placed on your immune system. Very, very special. The coffee that I had today was organic coffee infused with dual extracted organic chaga mushroom and lion's mane as well, which is affirmed by the University of Malaya to be neuroprotective and even stimulate the production of something called nerve growth factor in the brain. Just helping to be protective and to provide us with a better brain and better cognitive function.

6:01Shawn Stevenson:all of this is found in the think blend from four sigmatic head over to four sigmatic.com four slash model right now you're going to get up to 20 off of their amazing coffee blends in particular the think blend is my favorite it's the one that i use most often but they've got some amazing coffee blends they've got some half calf and they've got some higher caffeinated versions of coffee as well. So it's something for everybody. And also if you're not a fan of coffee, they've got dual extracted medicinal mushroom blends that I've been utilizing for years. These wonderful elixirs like their reishi elixir, their cordyceps and much, much more.

6:43Shawn Stevenson:They're just doing stuff the very best way possible. Head over there, check them out for sigmatic.com forward slash model. That's F O U R S I G M A T I C.com forward slash model. And now let's get to our special guest and topic of the day. Darshan Shah, MD, is a health and wellness specialist, board-certified surgeon, published author, and founder of NextHealth, the world's first and largest health optimization and longevity clinic. As a longevity medicine specialist, he's advised thousands of patients on how to optimize their well-being and extend their health span and lifespan. Dr. Shah began his career at an accelerated MD program and earned his medical degree at the age of 21, becoming one of the youngest doctors in the United States.

7:31Shawn Stevenson:He continued his training at the Mayo Clinic, one of the most prestigious medical institutes in the country. After earning his board certification and working with patients for many years, he continued his education and began work in training as a functional medicine doctor. Again, because of his pioneering and empowering work, he was recently named the number one longevity doctor in the world by the prestigious Longevity Doctors Association. And now we have him here to share his insights with us. Let's dive in this conversation with the one and only Dr. Darshan Shah. All right. It's so good to have a friend here and to hang out.

8:10Shawn Stevenson:I haven't seen you in a little while. How are you doing today? I'm doing fantastic today. Thank you for asking. Of course. The one and only Dr. Darshan Shah. You were just awarded the longevity doctor of the year by the renowned Longevity Doctors Association. How do you feel about that? Yeah, it's quite an honor. You know, I got into this field never thinking that this would turn into anything. You know, I was just doing it because I had seen the benefits of some of the advice I was giving on that, first of all, on myself and then on my patients. I'm like, let me just start a little clinic. And now to be here at this moment where, you know, I'm getting awards for longevity doctor of the year.

8:51And also I just got recently nominated by Athletec. You know what Athletec is? Functional Medicine Innovator of the Year. This is a big kind of media house around fitness and the fitness industry. So yeah, it's pretty amazing. I feel really good about it. And even though I don't need the recognition, I'm kind of like shy in that way, you know, but it's just kind of cool. Yeah. Yeah.

9:14Shawn Stevenson:And you know, they couldn't be a better person because just the place that you're coming from with this knowledge. And also you are one of the most generous people that I've ever been around in sharing what you know. And I don't think there's a better person that can help us to get through all the murkiness of the longevity conversation right now and get down to the bare bones. Like, what is this really? What this is really about? And what are the things that are affirmed by science to help us to extend our lifespan? So I think a good place for us to start, first and foremost, in this conversation about longevity, what does that actually mean?

9:49Yeah, it's such a good question. And you and I were talking about this a little bit earlier. The word longevity has been over-marketed now and it's become like a buzzword. And I feel that the term is like losing its significance a little bit. So I'm trying to bring the focus of the conversation back into what really is longevity. And what I mean by that is, it's not biohacking, right? It's not adding a bunch of years to your life that are nonproductive. But what it is to me is really how do we add health span into our years, right? And that's how you get years out of your life is adding more productive years where you still have your brain and your ability to recognize friends and family, where you still have the ability to move.

10:38Maybe you like traveling, golfing, whatever it is. You can still do that, right? where you don't have added risk to your life as well, risk of falling because you've lost your balance, added risk of maybe cancer, maybe all the chronic diseases, heart attack. How do you remove all those risks that we take for granted right now that it's just gonna happen to us, right? Like we think, I'll probably drive a heart attack because that's what most people will die of. And the reality of the situation is you don't have to die of a heart attack. We have the technology now and the tools now to prevent you from dying of a heart attack, Alzheimer's disease, cancer, metabolic disease, all the things that are killing most of us right now.

11:20And so to me, bringing the conversation back to what is really longevity. And to me, that is adding healthspan into our years and removing the risk of dying from something that we just take it for granted that this is what we're gonna die of.

11:33Shawn Stevenson:Right, right. Thank you. That is one of the most Captain Obvious things, but not so much now, because it's so focused on all the other stuff to do. A big part of this is not dying from the stuff that's preventable. Right. The most largely, the biggest killers in our world today, as you just mentioned, heart disease, cancer, diabetes is affecting all these other conditions. Obesity has exploded. Right. And so helping to prevent these issues, yes. But I don't think that we understand. And if you could, since I have you here, what is the current state of affair when we're talking about these chronic conditions?

12:09Shawn Stevenson:Is this now the norm? Are most people just kind of expecting? You just said it, like expecting to have a heart attack. Because of the current state of affairs, is the average person just going to have these diseases? So we are at a really interesting point in human history right now where we're actually reversing the trend of chronic disease, okay? So we have been increasing exponentially the number of people that are being diagnosed with a chronic disease over the last 50 years. But I really believe at this moment in 2025 that we've got to a point where we can reverse this trend now. And so we actually are seeing statistically less people dying of heart attacks, for example.

12:50And the nice thing about that is I feel that we're going to get to an accelerated reduction of chronic disease at this moment in time. So we're living in a really exciting time period. And there's a lot of reasons for that. I think there's good technology out that we're using sooner and is becoming cheaper, but also the mindset of just people has changed since COVID. I think there's a lot more conversation around health. Dr. Mark Hyman says all the time people are sick and tired of being sick and tired, and people now have access to information that they never had access to before. And so I feel really optimistic that you and I were talking about a kid born today, right?

13:36What is their life going to be like in 50, 60 years? I think chronic disease will not be something that they're necessarily worried about the way we worry about it today. Yeah. Yeah.

13:47Shawn Stevenson:So question, and I want to steer this towards, you've mentioned technology a couple of times. what are some of the things that you are utilizing in your practice that you're studying that you're considering when it comes to longevity and also some of the things that you are already you know you've been utilizing for quite some time and i've had the experience of having you know actually going with my wife to next health and having these incredible experiences like top to bottom you know the red light therapy the um hyperbaric oxygen the cryotherapy you got every iv that you can name you know but to do this with my friend my my wife my best friend and what i saw was that a lot of people were coming with a buddy or their significant other and like hanging out and doing all the things yeah so what are some of these technologies that are really supportive of longevity that you're into right now?

14:46Right. So what I would say is maybe I can take it a step back a little bit. Just once again, let's talk about the definition of longevity again. So being a doctor, like I always use medical terminology a little bit more, but when I was going through medical school, we talked about different types of medicine that were been kind of ignored in the Western medicine world of sick care. Right. And so when I look at the longevity conversation, I divide it into four verticals. Vertical number one is lifestyle medicine, okay? So this is something that doctors are told to practice, but they're not given any education on how to really practice lifestyle medicine well.

15:24And you talk a lot about this. I probably learned more from your podcast about lifestyle medicine than I did in medical school, to be honest with you. Sleep, exercise, nutrition, right? And avoidance of metabolic health problems, okay? So if you don't get enough sleep, if you don't get good nutrition, and if you don't have good movement in your life, you're going to be metabolically unhealthy, right? So one of the best pieces of technology in that vertical is a continuous glucose monitor, in my mind, all right? And we can talk about that more a little bit later. Second vertical is functional medicine.

15:57So functional medicine, again, is also ignored by sick care Western medicine because it is root cause medicine. It prevents chronic disease. So when you look at the root causes of why people are unhealthy, things like gut health, detoxifying their lifestyle, hormonal health, this all falls into the realm of functional medicine, stuff that in traditional medicine, you don't really talk about a lot. Like when was the last time you talked to your primary care doctor about your gut health, right? They send you to a gastroenterologist. But we have incredible tools and technology in that vertical now as well.

16:34We have hormone replacement therapy. We have the ability to measure your hormones and to do something about it even without hormone replacement therapy. Same with gut health. We can look at your gut health and we have great techniques now to restore your gut balance. Third vertical then is preventative medicine, okay? And preventative medicine is how do we prevent you from dying of a heart attack, Alzheimer's disease, or cancer. Incredible technology there. And the truth of that vertical is that we've had this technology for a while. We just used it way too late. So it was always like too little or too much too late is the way we practice Western medicine right now.

17:12If we can bring some of that technology into prevention, we can prevent all the chronic diseases. And then lastly, I talk about longevity medicine. And that is where we have also incredible new technology, regenerative medicine techniques like stem cells, exosomes peptides um we have also some of the biohacking stuff like you talked about like hyperbaric oxygen therapy um led light therapy and these have science behind them the only thing i will say about longevity medicine is that if you don't have those first three verticals addressed and perfected the stuff in the longevity medicine vertical is not going to be as effective or it just simply won't work, you know?

17:58And so you have to kind of take it in that order, right? And this is the practice. This is how we practice medicine now in Nexel. This is our entire kind of longevity medicine practice and how we do things. And that's the structure that we have around it.

18:11Shawn Stevenson:Thank you so much for sharing that. Because, you know, we have colleagues that get obsessed with that fourth pillar. Yeah, absolutely. And just like they're looking for that thing and completely missing the ball. Like, this is going to be radically ineffective if you're not doing these other things. We're just going to be trying to cancel out all the other problems. Right. Essentially trying to. Trying to. Yeah. Thank you for that, man. So. No, no problem. No, I was going to say like, you know, the human body is a biological mechanism that's always affected by the inputs that you're putting into it.

18:46Right. And so if you're doing all these biohacking things, but you haven't fixed the inputs, you're just chasing your tail constantly, right? And the inputs are 100 times more consequential than doing some of these biohacks, right? So, and the inputs are diet, toxins, you know, movement. All of these things are inputs. And you got to fix your inputs before you do any of these biohacking technologies. And look, like, I'm not saying they don't work. Obviously, like we have them in Nextel, they work. But I don't want anyone getting into a hyperbaric chamber until they've talked to me about all this other stuff first.

19:24Shawn Stevenson:I love it. I love it. So since I have you here, I want to ask you about some of these emerging supplements and things that people are implementing. You know, I get a lot of questions about these kind of things. And to have you here again is very special. But NAD is one of those things that a lot of people are interested in talking about. And I'm asking this specifically because I was leaving the gym just yesterday. and a guy stopped me who sees me all the time. He's like, yo, like I saw you, you popped up on my feed. He's like, I didn't know you were one of those guys. So he just starts asking me all these health questions.

20:02Shawn Stevenson:And he mentioned that he was utilizing NAD. And so first of all, what is NAD? And what are the best practices? And who is this implicated for? Great, great question. Okay, so NAD is a molecule that without it, we would be dead, basically, because there's a precursor for energy being made in our mitochondria at the cellular level. Obviously, every cell in our body needs energy to perform its function. And if you don't have enough energy, the function of that cell is not optimal, right? So having enough energy is the key to life. And we figured out how to give people that precursor, either an oral or IV form.

20:46And there's different ways of getting this precursor. But as long as it gets inside the cell as NAD, your mitochondria can turn that into ATP, which is energy. So obviously, you know, we all want as much energy as possible, right? And this is not just energy, like I feel energetic today. It's the energy for your liver to detoxify. It's the energy for your brain to keep you moving, all of it. And so you can take NAD in the form of either NAD, NMN, or nicotinamide riboside, and R, which goes by the trade name of Niagen. So those are the three forms of NAD that you can take. What a lot of people notice when they take NAD is they have more energy.

21:29And specifically, like in low energy states, like after traveling or after you've been sick, it can get you better much more quickly, right? So those are the kind of people that use NAD. I also like to use NAD on a daily basis. And so I use it orally. What I found is that niagen or NR is the form of NAD that is absorbed the best into the cell. And this is why that's the product that I use. There's also IV versions of NAD. IV NAD, if you've ever had it before, it's very uncomfortable because when you give IV NAD, your immune system has a reaction to it because NAD is supposed to be inside your cell, not outside your cell floating around in your bloodstream.

22:13So people get chest pain. People get a feeling of nausea when they're taking it. IV NR, Niagen, again, is absorbed incredibly rapidly into the cell. And so you don't feel as bad as you do with IV and AD. And because it's absorbed more rapidly, it actually has a better intercellular concentration as well. So that's like the big picture on NAD. Now there is NMN as well, you've probably heard of, right? And there's a lot of research going around about that as well. Unfortunately, the FDA took it off the market because they're going to consider it as a drug, actually. And so a lot more research needs to be done for NMN to come back into the market.

22:50Some people are getting it in supplement form. But I think there's great research around NMN as well, but it's just harder to get.

22:59Shawn Stevenson:Got it. So you mentioned a nicotinamide version, which got me thinking about this category of nicotine. Ah, yeah. Right? And so now this is kind of having an emergence in the longevity space in particular, but also around cognitive function. But when I think about nicotine, I think about ciggies. I think about smoking. So what's going on there? Is nicotine something that's dangerous for humans? Do you think that this is a potential benefit? Talk about that one for me. Yeah, I mean, I actually use nicotine sometimes, and I use it in the form of an absorbable pouch that you can put inside your mouth, right?

23:37And nicotine, we know, is a cognitive and performance enhancer, and I use it sometimes before I do a podcast, to be honest with you. And I like it for that. nicotine and cigarettes however um obviously the cigarette has a lot of respiratory consequences causes cancer so you don't want to have um you don't want to smoke it um but the problem with nicotine is for some people it can be extremely addictive right and so that's why people get addicted to cigarettes right and so if you are one of these people that get addicted to nicotine you probably want to reduce your consumption of it however if you use if you're one of these people that can manage your intake and you can use it for cognitive enhancement.

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24:19A lot of athletes are using nicotine as well. The form that I use is called athletic nicotine and I love it for cognitive enhancement and performance enhancement.

24:28Shawn Stevenson:Fascinating, fascinating. So there are any other, because again, we tie that so closely to smoking. Are there any other like negative implications if you're utilizing even a nicotine supplement? I mean, I think the main thing is the addiction of it. And so other than that, the dose is always a poison, right? If you can control your dosage, you're using it for specific situations, I think that it can be valuable. But obviously overdosing and getting addicted to it is going to be a problem. Got it. Well, going back to one of the hallmarks of longevity, which is not dying. Not dying from things, especially things that are preventable, largely preventable.

25:10Shawn Stevenson:and the number one cause of death here in the United States and also worldwide, but we're the kings of it, is heart disease. You've got some information about potentially being able to detect heart attacks decades before they happen. Talk about that. Yeah, no, I mean, look, once again, we're living in a really exciting time right now that we can look at the arteries of your heart with a CAT scan and use AI to lay out every artery and see exactly how much plaque you have and where it's at, right? And so for decades, all we did was follow cholesterol levels because we're looking at that as a risk factor, right?

25:51We're looking at your risk factors and we're saying, how at risk are you of heart attack, right? But now we can see with incredible clarity with a non-invasive scan what's going on with your heart. This is called the Clearly Scan. and this is a game changer for cardiology because if you can do a clearly scan early enough and detect plaque enough, you know how aggressive you need to be with mitigating all of the risk factors for heart disease. The risk factors for heart disease are not just high cholesterol. They're also inflammation. They're also metabolic disease. They're also hypertension, high blood pressure.

26:29You have to work on all of those to reduce your risk of heart disease, not just your cholesterol level. And but prior, all we had was, you know, blood pressure and cholesterol. So we would throw medications at it. I could tell you I have patients that have total cholesterols that are really high, like 250, and they have zero plaque on there, clearly. And I can tell you I have patients with low cholesterol levels and they have a lot of plaque in their arteries. And there's reasons for that. Right. And so now with the ability to see with the scan beautifully what these arteries are doing, you can totally prevent yourself from having a heart attack.

27:07Shawn Stevenson:One of my biggest concerns over the years, again, really being acclimated to the research around cholesterol, again, for years. And looking at this number without context has been the habitual problem. And people come in into my office, you know, I was working as a nutritionist for many years. And they're like, you know, I've got this, you know, my cholesterol is high, you know, I'm on the statin, da-da-da. But I'm just like, there's so much more here to this. There's a picture here that your blood work will be telling if you're more educated on the blood work. And unfortunately, a lot of physicians are not educated on that connection.

27:41Shawn Stevenson:Because you just said that somebody could have a high cholesterol number, but not have these plaques showing up to that extreme degree, but their cholesterol could be lower, other people, and have higher amounts of plaque. There's other factors involved here that can make cholesterol dangerous. Let's talk about that. Yeah, yeah, sure. So the reason people get plaque is three reasons. And cholesterol is the last reason, actually. The first reason is there's some damage to the wall of the artery, okay? That's called the endothelium, and there's another layer called the glycocalyx. Once this gets damaged, it starts to allow cholesterol into the artery wall, okay?

28:23The reason you can damage the blood vessel is by overtraining, high blood pressure, a lot of stress can do it, metabolic health issues can do it. All of these are damaging to the inside of your blood vessel. So step one is don't damage the inside of your blood vessel, right? Step two then is cholesterol enters the blood vessel. And this causes the plaque that we talk about. Because once cholesterol enters in there, your body realizes that it's not supposed to be there and it sets off a cascade with your immune system called inflammation, right? So it's a combination of all of these factors that work together to create the plaque inside the artery wall.

29:06And why is plaque bad? Well, because your arteries are tiny. I used to do heart surgery and I used to operate on these arteries and bypass them on people. They're tiny. They're like, you have to use a microscope to sew into them, right? So a little bit of cholesterol accumulating in there can block that artery. But what can also happen, and this is why, you know, 50 % of all heart attacks are, 50 % of heart disease is diagnosed as someone's first heart attack, right? And that's because sometimes when you get cholesterol in the artery wall, you can also get a clot forming in that artery as well.

29:40and this kind of plaque is very dangerous plaque and typically we've never had any way to see if you have this dangerous plaque or not unless you got an angiogram which is a very invasive test so that's clearly a test again once again shows you with even better clarity than an angiogram if you have some of this dangerous plaque as well which makes it more urgent that you do something about it Yeah. So, you know, there's lots of reasons why people get plaque. You have to kind of manage all of those reasons. And like I said, just because you have high cholesterol doesn't mean you need to be put on a statin, you know?

30:19Shawn Stevenson:Yeah. Yeah. Okay. Now all of these factors and being able to deep dive and do more comprehensive tests are now available, right? So if you're wondering, okay, so my cholesterol, these are my numbers here, but what is the context they're existing in? Do I have high levels of inflammation that could be interacting here? My metabolic health, do I have abnormal, you know, management of my blood sugar? Like, how does all this play together, right? And so our blood work, if we're getting something comprehensive, can really tell us a great story. And now we've got this testing that you're talking about with Cleary, clearly that you can actually get a look at what's going on inside and see from that perspective as well.

30:59Yeah, exactly. Every single person listening to this podcast, I don't care if you're, you know, maybe less, maybe if you're 21 and over, if you're listening to this podcast, should go and get their blood work done, right? And look, we live in 2025. You should be able to ask your doctor for it. If they're not going to do it for you, either find a new doctor or just go and get it done yourself. It's not that expensive anymore to do this. Once you understand what your blood biomarkers are telling you, you can avoid heart attacks or any of these diseases, you know. And so I put a guide on my website, actually, if you want to have people get a guide to their biomarkers, which ones they should ask for, what is the optimal range, and why it's important to get into optimal.

31:43And there's only like 15 of them. There's not a lot of them. you will dramatically affect the course of your longevity and your health span for sure and every

31:52Shawn Stevenson:person should be doing this for themselves absolutely just get a get a look at what's going on yeah instead of just wondering and questioning and what i use and i'm just going to share this with everybody is a comprehensive plant panel it's like over 100 biomarkers hormone levels immune system markers uh inflammatory markers the list goes on and on and obviously the cholesterol panels and the other general stuff, but so much more expansive. And it feeds you back also a biological age. And so I got to see, which was pretty cool. I'm eight years younger biologically than I am chronologically. And it's just using the most advanced technology to get this data all put together for you.

32:35And that's number one.

32:37Shawn Stevenson:Number two, also being able to keep an eye on your metabolic health with continuous glucose monitors as well. And so we both love levels for that and so that's the company that i've been working with when i'm getting my own blood work done and if you want to check out levels go to levels.link forward slash model and you can get two months for free when you get their annual membership and they just added in they give you a free 20 marker blood test annually as part of your membership right and so but i just did the add-on where i can get the even more expansive blood panel done so they're really doing some cool stuff levels.link forward slash model you know i love my levels app too is you can take a picture of your food and it's pretty accurate about how much protein is in it micronutrients like it's amazing and you know like sometimes you go to a restaurant like there's no way it's going to recognize what that is and it does it's great i mean but of course of course with the technology is there to do that stuff yeah so the other thing i tell people is with their biomarkers too is once you get your blood test done so i first of all like you're you're super advanced and you have a lot of knowledge obviously most people are really just kind of starting on down this path and but whatever blood markers you get done now you can upload them to chat gpt and it will kind of tell you what to look at now obviously it's not going to give you any intervention so you still want to talk to a doctor before you change anything um or take medications But I mean, the tools are all out there now for everyone to become the CEO of their own health.

34:11Right. And so I think it's so important for people to start doing it now because we've outsourced our health to, you know, who we thought was taking care of it for. And this is not a knock to all the primary care doctors out there. Right. But primary care doctors are basically you're outsourcing your entire health to this person that sees you once a year for 30 minutes. if that yeah if that and they're just trying to like make sure you don't have a disease you know and it's so there's so much more good information in those blood tests than people really realize

34:41Shawn Stevenson:yeah yeah and also again some of these companies providing personalized plans for you based off your unique blood work yeah it's very special this is for me is the right use of technology yes there's a lot going on with technology obviously and some stuff is you know i'm conflicted about because i think it's like really dumbing us down but we can free up some capacity for ourselves to learn right when i'm thinking about dumbing ourselves down i'm thinking about we don't have to remember stuff now like remember phone numbers whatever what happens to that space in your brain if you're not using it proactively for you know memory right that part of the brain is just going to basically, you know, kind of just degrade.

35:24Shawn Stevenson:And right now we have the opportunity to proactively utilize technology for our betterment, but we got to be intentional about it, you know? And so we have access. One of those benefits is right now what everybody is doing, who's a part of this conversation, they're proactively listening and learning to something to empower them. Right. And you could use that same time and, you know, I don't want to throw out any names, but like you could be up into the, you know, Kanye beef or whatever. You know what I mean? There's infinite stuff for you to be, you know, concerning your attention with that's here today, gone today.

35:59Shawn Stevenson:Or you can study things that are more life affirming and sustainable. And you've never, none of us have ever had such close proximity. They get to learn from the person who is the number one longevity doctor, right? And this is affirmed. This award is given to you by your peers and they get to learn from you. Oh, no, they got to do is push a button. That's priceless, man. Yeah. Priceless. Yeah, it's pretty, I mean, look, we live in an incredible age of information. The internet, artificial intelligence, podcasts, Like this, all of this information is all free for people now, right? And I think when you, as using biomarkers as an example, right?

36:45Don't just like get them and then, you know, put them in chat GPT and say, what do I do, right? Learn what they each mean. Because once you learn what each one of those numbers means, like hemoglobin A1C, HSCRP, you start putting this model in your head of where you need to focus your attention and you kind of gamified for yourself too, right? Like you're like watching your numbers get into the optimal range. And so I think that learning process is so empowering because now you actually know how the machine works, right? Your body works and the learning is just so self-sustaining too, right? You just keep wanting to know more.

37:25Shawn Stevenson:What do you feel is the most surprising thing for people as far as like something that is impacting their longevity in a negative way that most people have no idea about? I would say when you get your blood test back, there's probably three things I see that people are always surprised about. Number one is their hemoglobin A1c. This is a three-month average of their sugar. And most people have this in the range of suboptimal. And what I mean by suboptimal is that you want to optimize your blood test number. 5.2 or below to me is optimal. Most people are much closer to prediabetes or in prediabetes already, which is 5.7.

38:08The second thing is their testosterone level. Both men and women are always surprised. And it's mind-blowing to me how low testosterone levels are in the general population when I see blood tests right now. And third is their inflammation marker, HSCRP, highly sensitive C-reactive protein. um many people have this way over two or three actually and so we see a lot of surprises there as well optimal for that number is as close to zero as you can get it and so i think those are my three biggest categories of surprises um and um you know once you know what those numbers are you start making changes or going down a discovery path to see what's causing it powerful powerful

38:53Shawn Stevenson:Yeah, there's a, I mean, to put it bluntly, epidemic when it comes to testosterone. Epidemic. And of course, you know, we know some of the culprits now is really affirmed in the data, just the environmental input of these kind of estrogenic compounds, right? Xenoestrogens. We're just swimming in this stuff. And also it ties back. Testosterone is related to your hemoglobin A1C, right? Right. And so what's going on with your blood sugar, aromatization can be robbing. Even if you're making the testosterone, it can be getting converted into estrogen. Exactly. Right. Like and so all this stuff paints a picture and you can start to find out what what the issue is.

39:37Shawn Stevenson:And I love this so much, man. And that's one of those things, too, where my being mindful of your blood sugar management and seeing that long term. it's kind of like your blood glucose right now is like a snapshot versus something that's more extended, maybe like a long-term movie. What would be a good analogy for hemoglobin A1c versus a snapshot? Yeah, exactly. I think because it's a three-month average, it's giving you all of those habits added together over time, right? And so I guess a good analogy would be like, I don't know, watching the entire game versus just one inning, you know what I mean?

40:15Like when you watch this one inning, you only see like what those specific players did during that one inning. But when you watch the whole game, you get a really good feeling of the entire team and how it's working together, all of it. And so, yeah, you want to, but you also want to look at the snapshots too, right? Because the other important marker is fasting insulin level. So this is the first thing that changes when you start developing metabolic disease. Fasting insulin is the first detection of it. It's not fasting glucose, it's fasting insulin. Hemoglobin A1C changes after things are already broken, actually.

40:48So hemoglobin A1C is telling you like, things are really not going well for the last three months, like really not going well. And so another marker I talk about a lot is fasting insulin level.

41:00Shawn Stevenson:You know what's so crazy is that we're just now getting that as part of the conversation. Yeah. When this was a part of it all, the whole time. I know. The whole time. We've been able to check these markers now for decades, but no one talked about them, you know? And the average panel wasn't looking at that. Yeah, no. A lot of these markers, you can't even, if you ask your doctor to say, if you ask your doctor, I want a blood panel done, they wouldn't even check these things. They would check what's called the CBC, a complete blood count, or a chemistry profile, okay? All of that stuff is, if that stuff is in the red range or the bad range, like you have a bad problem already.

41:38A lot of people are not checking hemoglobin A1C, HSCRP. You know, all these things are not normally being checked. So you have to ask for them. So on my website, drshah.com slash biomarkers, there's a list of all the biomarkers. Just take it to your doctor and say, I want these.

41:53Shawn Stevenson:Awesome. Yeah. What a great resource. Now, something that can affect all of these biomarkers that we've talked about that is kind of insidious and even hidden in a way is stress. Yeah, for sure. I want to talk about the connection with stress and our lifespan. Yeah. So for me, stress is really something that we really need to kind of understand. How is your mental stress affecting you physiologically? Right. And so the whole concept of de-stressing, I think it's something that we spend way too much attention on because it's hard. We live in a very stressful environment. obviously we want to reduce the amount of time that we're exposed to stress.

42:38And the one main reason for that is because psychological stress can turn into physiological stress by the secretion of cortisol from your adrenal glands, right? And we know that if you have high levels of cortisol for long periods of time, it can lead to metabolic disease, it can lead to inflammation, all these problems. So when does psychological stress lead to cortisol release? It's after about 20 to 30 minutes, right? And so whatever you're doing, that's stressful. You're having a stressful conversation. You're on your computer banging away trying to do something and you're not in a flow state and it's stressful.

43:14If you could just break up those periods of time into 30-minute chunks and take a little break and kind of let your cortisol reset, you can really mitigate the negative physiological consequences of stress. Right. And so what do I do with that one? The hack there is I have an egg timer on my desk and I just put it to 30 minutes. And every 30 minutes I get up and I do something different. I'll either, you know, I'll do I'll do a little walk around the office or I'll do some jumping jacks. So I have some weights at my by my desk and so I lift some weights. And if you can break up that stress, it'll be extremely helpful.

43:56Shawn Stevenson:Oh, man, I love that. You know, one of the greatest metabolizers of stress are relationships. Absolutely. But they can also, on the other side, be one of the greatest contributors to our stress. And so it's not an accident that you proactively engage in healthy relationships and get people together. And that's one of the experiences that we had recently. There was a time before last that I saw you. We came to hang out at your house. And you invited over this amazing group of people. It was myself, my wife, Dr. Kelly Starrett, Juliette Starrett, Dr. Casey Means was there with her husband. And it was also Rob was there, who's big in the health and wellness space as far as like a background kind of producer guy.

44:46Shawn Stevenson:And also your amazing wife was there. And we just had this incredible experience. And it was something that was called a Jeffersonian dinner. Yes. Talk about that. Yeah. So Thomas Jefferson, you know, he couldn't hear very well out of one ear. So he was kind of deaf in one ear and his other ear was not that good either. And so when he would have people over, he made sure that only one person talked at a time. And so he would then ask a question and only one person could answer the question at a time. and then he would, if two people were talking or having a side conversation, he would take his ear and just kind of pull it forward and stop the whole conversation to get it back into one person talking at a time.

45:32And it's so powerful when you can do that, right? Because everyone's attention is focused on one person and that person gets to say something deep about what they want to talk about. Like we asked some questions going around the table, like what are you most excited about coming up in your life? How have you contributed to the conversation on longevity and health? And people really think about what they wanna answer. And so it's not just a random conversation. It's very thoughtful. And everyone puts their attention on one person. I love doing that. I do that on almost every single dinner now.

46:03Shawn Stevenson:Yeah, it was an incredible experience for sure to say the least. And also the cherry on top was, I had no idea that this was gonna happen. The dessert that was served was you blew me away man it was from my my cookbook yeah uh the eat smarter family cookbook and it just was just like are you kidding me man you know it's so awesome because i didn't know it at first and i took a bite i was like this tastes so familiar you know and the presentation you know the the energy the people as well why why was this something that you chose to do as far as like investing in relationships and getting people together like this?

46:42It's a rock in my life. I know that I am the happiest and I am the least stressed. And I have the best health when I am surrounded by people that are smart, that I really, I have like a genuine love for, you know, like I want to be around them. And I have great conversations that are meaningful and deep, you know. And to me, if I go more than a couple of weeks without something like that, I do get depressed. And so this is how I stay happy and I just stay vibrant in my own mind is having these kind of conversations.

47:20Shawn Stevenson:Yeah, yeah. We need each other. Even the most introverted among us, we need each other. We evolved in community. And today we know, and this was just actually published as of this recording, just very recently, looking at one of the biggest contributing agents, one of these, again, seemingly invisible issues to early death. And it was on social isolation and loneliness. And so this was a data set of over 2 million people. And it was a longitudinal study. So they're tracking them. This might be six months or even up to 25 years. And they found that people who felt lonely frequently, chronically lonely, had a 14 % increase in mortality.

48:08Shawn Stevenson:So premature death from all causes. But social isolation was more than twice that. So we're talking about somewhere around 35 % increased risk of early death when people are socially isolated. So the distinction is even if you can feel lonely around other people, but being around other people is still preventative. It's still nourishing. You're still getting these inputs. Yes. And some of these inputs are, again, most of them, they're invisible. Right. This change in our chemistry being around each other is something that we can't see, but we feel it. Right. We have an increase in oxytocin. We have a decrease in cortisol.

48:44Shawn Stevenson:Again, if it's people that you connect with and resonate with, we're also doing microbial data sharing. Yeah. Right. Our immune systems get a little light work, a little light, a little lift up, you know, being around each other. What happens when you're not around other people? You're not getting these inputs that you vitally need. And this is something for us to be more intentional about. Yeah, absolutely. It's so well said. And I think, you know, if you look at like all the pillars of health, right, some of them are obvious. Some of them are not so obvious. And, you know, this is one of them that's not so obvious is social isolation and community is a major pillar of health.

49:21And it's easy to forget because, you know, there's not hunger telling you that you need to when you're hungry, you know, you need to eat something right when you're tired, you need to sleep. But for this particular one, there's nothing they're telling you like I need to get out there and like be around other people more, you know, so and got to remember it.

49:40Shawn Stevenson:You're one of those people. And generally, you know, we all know somebody who's like a great connector of people. You put people together. You don't even know how much I love Kelly Starrett and Juliet. You don't even know. All right. And it just so happened we were all invited together on the same date. And like Juliet is one of those people that checks in on me. Like just it'll be like a random Tuesday. And she's like, hey, Sean, good morning. Just wanted to say I was thinking about you, send you lots of love, that kind of thing. That's awesome. Right. and not to mention Casey Meese like we've you know we're just like tight you know and so just being able to to get together this group of people that are so cohesive yeah and it's just very special man it's so valuable and my wife and I were just on a high oh I love it leaving there you know like and it lasts it kind of like stays on you yeah for you know days after it does yeah for sure yeah I'm very grateful and I didn't even know you guys all knew each other I was like right That's what I'm saying.

50:36These are all great people. They're really smart. We're all in the health and wellness conversation. Let's get together, you know? And so everyone kind of recognized everybody for the most part in some way or the other.

50:47Shawn Stevenson:Yeah, it's awesome, man. Yeah. Can't wait to do it again. I know, like yesterday, man. We got to get together. But, you know, with this being said, this is one metabolizer of stress. You mentioned essentially just walking away, breaking up that monotony of like being on your screen, working or whatever the case might be because of that buildup of stress. Right. So is there anything else? You said something along the lines of, you know, not really even believing in this like de-stressing paradigm. Like, can you talk a little bit more about that? Well, I guess what I'm trying to say is no one's going to live a life with no stress.

51:24No one's going to have a day with no stress. There's a scale that you can, you know, go online, take a test. It's called the stress inventory score. There's a lot of like things that are pretty positive on there too. Like I'm getting married. I'm in a new relationship, you know, but these are all still contributors of stress, right? Even though they're positive stress, if you don't kind of understand that stress is always going to be around us all the time, it's hard to like make any progress because you're not focusing on what is the treatment for that. And the treatment for that is breaking up the stress into smaller chunks, especially if it's work-related or conversationally related.

52:04The treatment is doing things like what you're talking about, being social more often. It's also like taking a vacation. Like, you know, I think there's a 70 % of Americans don't even take all their PTO days. It's crazy to me, you know?

52:18Shawn Stevenson:Whoa. Yeah, yeah. Or like having time for self-care. Like, you have to intentionally build in these routines into your life. Otherwise, the consequences will add up into negative physiological consequences, not just through cortisol, but also through things like drinking, being sedentary. Stress makes that happen too. Okay. Got it. Got it. Yeah. We're not going to find some bubble that we can exist in without stress. Yes, exactly. Yeah. So it's arming ourselves and understanding the situation we're dealing with. And there are simple things that we can do. Right. There's simple things we can do.

52:54Shawn Stevenson:Simple things, right. I got to ask you about this since I have you here. I mentioned microbial file sharing earlier. And obviously, or maybe not so obvious. And so right now we know that there is a huge connection between gut health, microbiome, and longevity. And again, having you here, I get to hear it from the guy. So what's going on with gut health and longevity? Like what is this association? and what are some things that we can do to fortify the health of our microbiome so that we could fortify our lifespan? Yeah, great question. Okay. So right now, we're still at the very beginning of our knowledge on this.

53:35We know there's a connection between our gut health and pretty much every other system in our body, whether it be your brain, your heart, obviously your liver, et cetera. There's definitely a connection there. And by gut health, I mean the status of your microbiome, right? We don't know exactly what microbials, other than a few of them that we are focused on, really make a big difference. We just know that you need to have diversity, and there's certain keystone microbials that you need to have in your gut that will promote health in the long term, okay? We also know that our gut microbiome is extremely important for a few other factors.

54:16Number one is that it prevents you from becoming metabolically unhealthy. Number two, it acts as an additional barrier to toxins getting into our system. And also number three, there's chemicals and communication molecules being made between our gut and every other system in our body. That if you don't have good diversity or just really poor microbial populations, that communication is lost. GLP-1, everyone's talking about these now, is one of those communication molecules that our gut actually makes, okay? So, and without a gut-healthy gut microbiome, we don't make a lot of GLP-1. That's why there's this obesity crisis, right?

54:58So what can you do as a second part of your question? Like, how do we keep our gut microbiome healthy? It's actually fairly simple. Number one, don't destroy your gut microbiome by ultra-processed food, pharmaceuticals like non-steroidal anti-inflammatory drugs or antibiotics. Obviously, if you're really sick, take an antibiotic. But don't take an antibiotic just because, you know, you're kind of feeling maybe you're sick. And thirdly, alcohol can also wreak havoc on your gut microbiome if you drink it in excess as well. And other things such as, I mentioned ultra-processed food already, right?

55:38Yeah. So avoid those things. Once you do avoid those things, your gut will naturally become healthier, okay? Now, there's a few additional things that you can do to keep your gut microbiome super healthy, and that is fiber intake is extremely important. Collagen intake is also extremely important. And so you need a varied diet, you know, to keep your gut microbiome healthy. There's some probiotics, I think, that are useful as well. There's this one called Acromantia, which is a keystone bacteria that helps us make GOP-1. That's very helpful. And yeah, I mean, that's kind of a good starting point right there.

56:19Shawn Stevenson:Awesome. Awesome. So you mentioned diversity as being one of those hallmarks. Yes. And we see in our modern society that our diversity of microbial species is significantly less than folks who are living more of what we would consider like a kind of more indigenous experience, hunter-gatherer, adjacent individuals that are being studied today. They can have four to even 10 times more diversity. So we have a lot of species of microbes in our culture in our own bodies that are going extinct or they're on the endangered species list. And so getting them back up to par is focusing on increasing diversity.

56:59Shawn Stevenson:So how do we do that? Is that maybe by increasing the diversity of what we're eating? Yeah, absolutely. This is increasing the diversity of what you're eating. Eating the rainbow, you know, having more fiber in your diet is also extremely important, but that's exactly how you do it. Increasing diversity of what you're eating. Got it. Fiber and fiber types. And fiber types, yeah. So, okay. So what do we want to do as far as, is there like maybe something for us to strive for, you know, each week, maybe, you know, I don't know, 20 different plant inputs. Yeah, I mean, I think that's a good place to start.

57:33I mean, there's some books that write about 100 different plants per week. I'm like, there's no way I can even find 100 different plants. I just start eating the flowers. Right, blend the flowers up. Yeah, but I think definitely at least 10 to 20 different plants per week is a good idea as far as diversity goes. But look, the reality is it's hard to kind of do that, right? So I just think just having a thought in your brain that every plate of food you eat should have some vegetables in it. And maybe definitely trying to diversify the types of vegetables throughout the week is also a good idea as well.

58:14Shawn Stevenson:Yeah. I just did that yesterday, actually. Because you can get into a rhythm or a rut eating the same things again and again and again. Especially, I think a lot of people do this a lot for breakfast. Like they had the same thing, getting this opportunity for some diversity, you know. And so actually my wife made the night before some, a recipe from the East Martyr family cookbook, which was the, it was the Greek salad bowl. Yes. And this bowl includes things like quinoa and arugula and this phenomenal dressing we've been making for, you know, I don't know, maybe 15 years. It's my favorite dressing.

58:54Shawn Stevenson:and just all these even the dressing itself and making the dressing which is super easy to make yourself has like fresh basil and all these different spices and so being able to get this input in cucumber tomatoes all these things that you normally wouldn't see in a conventional breakfast yeah right because i didn't have it the night before because i eaten a little bit earlier i was you know on the run but i was like i'm gonna have that tomorrow for breakfast yeah and i got in this diversity of plants that I normally wouldn't do in that breakfast meal. Yeah, no, that's awesome. Yeah, I think, you know, one way to kind of put more diversity into your food choices is to buy a good recipe book like yours, you know, and once you start experimenting with different recipes, you're going to naturally buy something you've never bought before, you know, and put into your food the next day.

59:44Shawn Stevenson:What are you most excited about right now? What am I most excited about right now? Well, we're kind of on a rocket ship with NextHealth, my clinical practice of, you know, I call it health optimization and longevity medicine. We're opening three locations next month. We're opening probably 30 locations in the next 365 days. And we're going to be the biggest practice of clinical longevity medicine in the world by, you know, in a year. And I'm super excited about it. And when I say biggest practice, I mean we have four-wall clinics that people can go to and use these technologies, meet with a medical practitioner, get their blood tests done, and we put it all together for people under those four pillars.

1:00:32And so I really feel like we're creating a new system of health care. Our previous health care system was really just sick care. we want to create a new parallel system that is true healthcare that keeps you healthy keeps you vibrant keeps you functional for as long as possible um and i think that's the definition of longevity you know that when we you asked earlier in the podcast the first thing you asked me that i really feel like having a place to go where you can experience those four verticals is what we're trying to create yes you're doing it about it you're doing it it's awesome it is so

1:01:06Shawn Stevenson:awesome and inspiring. Can you let people know where they can find a clinic and also just where they can connect with you and get more information? Yeah. So if you go to next-health.com, there's a list of all of our clinics and where we're coming. Right now we're LA, we're New York, we are going to be in Newport Beach, Chicago, we're Nashville as well, Montecito, Santa Barbara area, but we're going to be everywhere in the next few months. And so just, they can find the clinics on the website i'm at dr shah.com is my website for me personally and um i also have an instagram presence of course at darshan shah md and you also have a amazing podcast yeah that by the way thanks to you you know when you interviewed me uh you kind of gave me the push to make it happen and i did you did and you this is the thing about you and i share this with you certain people like yourself if you give them you know this kind of nudge to do this particular thing you don't just do it you do it exceedingly well like i'm talking top tier out of the gate because of the person that you are the knowledge that you have um the the warmness that you have as well but also just knowing how to create a system around things right and having good people and just the studio setup and the placement and just like it was all like you've been doing this forever basically right out of the gate.

1:02:27Shawn Stevenson:So it was super fun to even experience this and to see this. And my first revelation that, oh, it's out is actually, I came out of an interview that I was doing in West Hollywood and I see this gigantic billboard for your show. I was like, I know that guy. And I took a picture, I text you. I was like, yo, the show is out. He was like, yeah, man, yeah, man. So it's just, it's amazing. So people can find your show. Extend, yeah. Extend, the Extend podcast where they're listening to this podcast. Yeah, what we really try to do is, there's a lot of medical information out there. My whole goal with the podcast is to make it so that people understand it.

1:03:04And it's easy for people to have take-home value. And that's another thing I got from you. I always learn something that I'm gonna do after I listen to an episode. And so that's the whole goal. And yeah, Extend is the name of the podcast. We're on episode 65 already, which is amazing. And thank you for coming on the show. It was awesome. Every year we got to do this.

1:03:24Shawn Stevenson:Yes, for sure. For sure. Well, this has just been a joy. I love talking with you. It's always inspiring, always getting new insights. And I just appreciate you so much. I appreciate you so much, man. Thank you for being a great friend. Awesome. Yes, my guy, the one and only Dr. Darshan Shah. Thanks. Thank you so much for tuning into this episode today. I hope that you got a lot of value out of this. Again, we get to learn from the very best people in the world in their respective fields. And Darshan is really leading the charge in longevity medicine. As he mentioned, the importance of getting a blood panel done.

1:03:56Shawn Stevenson:We don't have to solely rely on guesswork anymore. And also the technology, the innovations in understanding our blood work and the story, the important messages that our body's providing us at all time. It's never been more accurate and easier for us to get this information. This is something that you no longer need permission to do, to have someone gatekeep and keep it from you. You can access this information wherever you are right now. There are clinics all over the country that can collect your blood work and then you can utilize the phenomenal levels app and this amazing team to actually read this blood work and to give you valuable information.

1:04:38Shawn Stevenson:I recently did this and I was able to get all of my hormones analyzed, my immune system markers, metabolic health markers, nutrient levels in my body, everything that I could even think of and more, and also to be able to put it all together in easy to read and to understand readouts of all these data points and to see the ranges that my body is in, in all these various aspects. And I was really surprised there was one nutrient that my body was lacking was in the lower end on and something that impacts so many other factors. And of course, getting this biological age back is really awesome, but I could be even younger, already younger biologically than chronologically, but I could be potentially even younger by addressing that one key nutrient.

1:05:26Shawn Stevenson:And so invaluable information. Sometimes our body is already telling us things and we just need to get it affirmed like what is going on, what is going wrong. And sometimes it's just, there might be something going on that's leading to a problem in the future that we can circumvent and avoid by getting this information. So again, head over to levels.link forward slash model. That's L-E-V-E-L-S dot L-I-N-K forward slash M-O-D-E-L to take advantage of the Levels membership. If you get the annual membership, you're going to get two additional months for free. And as Darshan shared, The Levels app is amazing.

1:06:10Shawn Stevenson:It is absolutely amazing, all the value that you get through Levels. And you also get access to CGMs, continuous glucose monitors. And they're also now providing you with, as part of your Levels membership, an annual biometrics test for 20 of the most important biomarkers. But you can also get an upgrade. You can invest in an upgrade to get that comprehensive test like I did. to get over a hundred of your biomarkers checked off and studied. And the data is delivered right to your device, your computer, your phone, in a way that you can understand what your blood work is actually telling you. So incredibly valuable.

1:06:54Shawn Stevenson:And again, make sure to check out Dr. Darshan Shah's podcast, Extend as well, where you're listening to podcasts. He has some phenomenal guests. I was over at his studio recently and got the experience and to see what he created. and it's just really amazing. He's such a big heart and just an amazing person. And I'm grateful to be able to share this conversation with you today. Listen, we've got some amazing, I'm talking about amazing guests coming up here very soon and also some powerful, powerful masterclasses. So make sure to stay tuned. Take care, have an amazing day, and I'll talk with you soon.

1:07:28Shawn Stevenson:And for more after the show, make sure to head over to themodelhealthshow.com. That's where you can find all of the show notes. You can find transcriptions, videos for each episode. And if you got a comment, you can leave me a comment there as well. And please make sure to head over to iTunes and leave us a rating to let everybody know that the show is awesome. And I appreciate that so much. And take care. I promise to keep giving you more powerful, empowering, great content to help you transform your life. Thanks for tuning in.

From the publisher

In our modern healthcare system, most people don’t realize they’ve developed a chronic illness until their quality of life is reduced by painful symptoms. But if you regularly measure and monitor your body’s biomarkers, you’re much more likely to prevent disease and extend your healthspan. On today’s show, I’m excited to share this conversation with the longevity doctor of the year. Dr. Darshan Shah is a board-certified surgeon and the founder of Next Health, the world’s first Health Optimization and Longevity Clinic. Today, he’s back on The Model Health Show for an illuminating conversation on the world of longevity medicine and what it actually takes to live a longer, healthier life. In this interview, Dr. Shah is sharing the four main components of longevity medicine and how to take advantage of them for better health. You’re going to learn about the main biomarkers that can affect your health and predict your risk for chronic disease, how to reduce stress and avoid heart disease, and the critical inputs your body needs more than any biohacking tool. Dr. Darshan Shah has a wealth of knowledge in the realm of optimizing health and extending your lifespan, and I know you’re going to love these powerful insights. Enjoy!  
In this episode you’ll discover: 
The true definition of longevity. (9:53)
How we can reverse the trend of chronic diseases. (12:22)
The four verticals of longevity medicine. (15:09)
How to measure your metabolic health. (15:47)
What functional medicine is, and its evolving technology. (15:58)
Why preventative medicine hasn’t been used correctly in our healthcare system. (16:53)
The different tools that longevity medicine can provide. (17:20)
Why lifestyle inputs are more important than biohacking tools. (17:45)
What NAD is and how to use it. (20:16)
The pros and cons of using nicotine. (23:29)
Why the diagnostics of heart disease are evolving. (25:29)
How to avoid heart disease. (26:19)
Why regularly getting bloodwork assessed is important. (31:01)
What it means to be the CEO of your health. (34:06)
The three biomarkers that are negatively impacting our longevity. (37:38)
How stress and longevity are connected. (42:13)
A strategy for mitigating your overall stress load. (43:03)
The link between gut health and longevity. (53:30)
How to improve your gut health. (55:01) 
Items mentioned in this episode include: 

Foursigmatic.com/model - Get an exclusive discount on your daily health elixirs!

Levels.link/model - Join today and get 2 free months with a one-year membership! 

Next Health - Visit Dr. Shah’s health optimization and longevity clinic!

DrShah.com/biomarkers - Get your free biomarker guide! 

The Stress Inventory Score - Find your risk of stress-induced health conditions. 

Athletic Nicotine - Learn more about clean, slow-release nicotine.
Connect with Dr. Darshan Shah Website / Podcast / Instagram  
Be sure you are subscribed to this podcast to automatically receive your episodes:  
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This episode of The Model Health Show is brought to you by Four Sigmatic and Levels. Visit foursigmatic.com/model to get an exclusive discount on mushroom and adaptogen-packed blends to improve your life. Learn how food affects your health with a continuous glucose monitor (CGM) from Levels. Join today at levels.link/model and get 2 free months with a one-year membership! 

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