Natural Ozempic, Peptide Clinics & What’s Really Driving Hunger

30:56A very interesting story there and so much more. So we'll see you in a sec.

31:04Starting or growing your own business can be intimidating and lonely at times. Your to-do list may feel endless with new tasks, and lists can easily begin to overrun your life. So finding the right tool that not only helps you out, but simplifies everything as a built-in business partner can be a game changer. For millions of businesses, that tool is Shopify. Shopify is the commerce platform behind millions of businesses around the world and 10 % of all e-commerce in the U.S. from household names like Gymshark, Rare Beauty, and Heinz, to brands just getting started. Shopify has hundreds of ready-to-use templates that can help you build a beautiful online store that matches your brand's style.

31:45And you can tackle all the important tasks in one place, from inventory to payments to analytics and more. No need to save multiple websites or try to figure out what platform is hosting the tool that you need. And if people haven't heard about your brand, you can get the word out like you have a marketing team behind you with easy to run email and social media campaigns to reach customers wherever they're scrolling or strolling. Start your business today with the industry's best business partner, Shopify, and start hearing. Sign up for your$1 per month trial today at shopify.com slash realm. Go to shopify.com slash realm.

32:23That's shopify.com slash realm.

32:30Good sleep is everything. That's why Oli's science back support is made with a blend of melatonin and L-theanine for both kiddos and grownups. So when your mind won't switch off, you've got something that can help. Erasing thoughts and restless nights won't stand a chance. Find Oli's sleep solutions for the whole family at Oli.com. That's O-L-L-Y dot com.

32:56Thank you guys so much for that. we are moving into headline two. Okay, so headline two is very different. Aspirin cancer risk and why this matters now because aspirin has been shown to potentially reduce risk of cancer and then we're starting to understand more why and it's actually from the BBC and it does sound almost too good to pursue doesn't it but a 4 ,000 year old drug, you know, most commonly used for pain relief potentially can prevent certain tumour, Zella, from forming and spreading. Oh my gosh, if this interests you I so recommend going to BBC and reading this article I then read kind of quite a lot else on it and obviously we know so much about this but it's such it's a very thorough article and it's so interesting I actually didn't know anything about the history of aspirin either I know but it's absolutely extraordinary so there have basically been a series of new trials and studies that reinforce this potential link and interestingly some countries have already updated medical guidance to include aspirin as a first line prevention strategy for really really important high risk groups this is not for everyone yet don't go out by aspirin everybody and again the stressing is kind of under medical supervision which some of these high risk groups will be anyway but i don't know if you guys know this i didn't know this aspirin actually goes back thousands and thousands of years so in the late 19th century some archaeologists uncovered these four and a half thousand year old clay tablets from the ancient mesopotamian city of Nippur.

34:21I don't know if I'm saying that right, but it's in what's now modern day Iraq. And these tablets listed early medicines made from plant, animal and mineral compounds, including a substance derived from the bark of a willow tree. And that contains something called salicin. Is that how you say it? Yeah, salicin. Salicin, which the body converts into salicylic acid, which helps to relieve pain. And it's structurally very similar to modern aspirin, which is a different type of acid. But anyway, so the original form apparently was much, much harsher on the stomach. But that's the kind of inspiration, as I understand.

34:55And then other ancient civilizations, the Egyptians, the Greeks, the Romans also all used it. And then in 1763, there was an English cleric and he described the fever reducing effects of powdered willow bark to the Royal Society. And then about a century later, scientists refined it into this less irritating form, this synthetic form, which is aspirin today. Isn't it fascinating how all these ancient medicinal systems, the discovery of everything. It's so cool. It is very cool. It's actually mind-blowing. But by 1972, researchers were basically starting to explore its role beyond pain relief. And a study in mice, so we've got animal studies first, found that adding aspirin to drinking water did reduce the spread of cancer cells, which we call metastasis, and compared to those that weren't given the drug.

35:43So it was a trial in mice. But then the interest grew further in 2010. So this is when Professor Peter Rothwell at the Oxford University reanalyzed large data sets that were originally collected to have a look at cardiovascular benefits and aspirin. So I think that's where most people might actually know aspirin from, blood thinning and all sorts of things. And his findings suggested that aspirin didn't just help prevent heart disease. It also appeared to reduce, of course, the incidence of cancer and its spread. And the research continued. And then from that moment, we're looking at those high risk groups.

36:16So one of the most important studies we've got focused on patients with Lynch syndrome, which is a genetic condition. And that significantly increases your risk, sadly, of colorectal cancer and some other cancers there too. And in 2020, a landmark RCT, so a randomized control trial, 861 participants followed them for over 10 years long and found that those that took 600 milligram doses of aspirin for at least two years, they had to take it for two years, 600 milligrams, found they had a 50%, that's a half lower risk of developing colorectal cancer. Yeah. And these were all people who had this syndrome, this predisposed.

36:56Lynch syndrome. Yeah. Yeah. Which predisposes you for the risk of colorectal cancers. Exactly. Really, really helping me out there. Yeah. No, no. But it's honestly, I think we're just a bit gobsmacked by it. It's extraordinary, isn't it? Now, it's so important to say this, guys. Aspirin isn't a risk-free drug. It has side effects, could be indigestion, could be stomach ulcers, could be internal bleeding, even like the very small likelihood brain hemorrhage. So generally speaking, this is why the advice for the whole population is not go out and take aspirin every single day. You can't just take it with so many different ailments as well, I think.

37:28Or if you're on certain medication, if you're pregnant, I believe it's a different areas of when you can and can't have aspirin. Interestingly, apparently the UK guidelines are now recommending that people with Lynch syndrome consider taking aspirin from around the age of 20 or 35 in milder cases under medical guidance, of course. But that's because they're really starting to look at this, which is extraordinary. They're seeing a lot of new discoveries. Ella and I actually have some other headlines that I'm sure are going to come on cancer research, which is absolutely fascinating, that's coming up.

37:56But research led by Martin looked at patients with colorectal cancer who carry the specific genetic mutation, something that's seen in around 40 % of cases of this particular cancer. And in a three-year trial of 2 ,980 patients, those that took 160 milligrams of aspirin a day after a surgery, and they had less than half the risk of cancer recurrence compared to placebo groups. So we're now looking at the chance of cancer coming back, as well as a reduced risk of cancer spreading of cells to begin with as a preventative measure. So we're looking at prevention. It's extraordinary. So apparently in Sweden, so since January this year in Sweden, patients are now routinely screened that they had these mutations that offered low dose aspirin.

38:39Isn't that amazing? It's preventative. We were talking about preventative generational shifts last week with smoking and diet. And now thinking about the fact that finally, perhaps in cancer research, we're able to look at more prevention based methods rather than just, you know, dealing with the sad diagnosis once you get it. So, guys, we will check back in on this next year because there is a big ongoing trial. It's got 11 ,000 participants there across the UK, Ireland and India. And they have colorectal breast gastroesophageal or prostate cancer. And they're testing daily doses for these people of 100 or 300 milligrams of aspirin.

39:15And so, yeah, those results apparently are expected next year. So that is going to be so interesting. Anyway, there were loads of doctors talking about different theories of why this might work. But one of the theories and the leading theories, if I understand, is that aspirin could help the immune system better recognize cancer cells. Because obviously, I think that's quite widely understood that one of the issues is the cancer cells are very good at evading the immune system and kind of hiding. So essentially, it's making those cells more visible so the body can better respond and remove them, which is extraordinary, isn't it?

39:44So yeah, a reminder of something good to come, I think, something promising. But of course, lots of nuances always. Be careful in real life. We just want to raise some positive research that's coming our way. Yeah, and also just one of those things you read and you're like, oh my God, that's crazy. It's more as well, the link to the history of it all. I just find it so absolutely fascinating. It's one of my favourite areas of studies looking at the history of things. So headline three is what really controls our appetite? Is it hunger, stress or habit? I actually love this headline. This was honestly so much homework for you guys.

40:18This was in The Guardian. Really recommend reading this as well. This was one of the best pieces of journalism on health and wellness that I have personally almost read since we started doing this show. It was so non-scary and it was so incredibly helpful. And it's essentially exactly as Rhi said, like how do we know the difference between hunger and appetite and understand like all the cues behind it. And there was this amazing analogy that the piece started with that I think we can all relate to. It's like imagine you're sitting in a meeting room at work and someone brings out a plate of biscuits.

40:49So you've got like a packet of Jeremy Dodgers or whatever on it. And then maybe you want one, maybe you don't. But the chances are is that someone around you is going to react really differently. So someone's going to grab a couple straight away. Someone else eats one slowly, doesn't seem like that bothered, almost noticing it. another person like barely registers the biscuits are there just like keeps going and someone else spends the whole meeting wanting one and like almost itchy because they're not going to take it and i think that's a really relatable and a good analogy and i was curious really who of those people are you are you going straight for the biscuits are you mulling it over i'd decide what the best one on the plate is first yeah i don't really fancy a jammy dodger i think i really yeah i would have gone for a custard cream or um and i wouldn't have gone for the chocolate ball what What do you call it?

41:36Oh my God, I used to love chocolate ballgards. See, I never liked those. I preferred the custard creams. I would eat the middle out. I always thought custard creams were really average. Did you? See, this is it. I've always preferred vanilla to chocolate with ice cream as well. I prefer vanilla. I don't like chocolate ice cream, but I like a chocolate biscuit. So you see, there is a lot of different thought that goes into which biscuit and how you pick it. But then when I was reflecting on which one of those ones I would be, it was exactly as the article says, it would depend on the day. Like there'll be days where I'm like, couldn't care less about the biscuits.

42:05and there'll be other days where I'm stressed and I'll be like, give me all the biscuits. Yeah, or you've forgotten to have like your breakfast that morning. You're starving. Starving hungry. Other days where I'd eat one over an hour. Like I just like, I thought it was really, really good. Anyways, there's so many reasons why you might oscillate between being those different characters. And the reason we like this type of journalism is because it's not clickbait, it's educational. That's why we like it, Ella, because it actually explores psychology of eating and the reason that hunger is not just the simple thing we can control with our head.

42:35It just does not work that way. So it's, you know, the feeling, how you feel things. If it was a plate of fruit versus a plate of biscuits, I'd also ask what the decision making process would be for many people. Would they give or take? You know, exactly. And that's really different, isn't it, between hunger and appetite, isn't it? Because it's like appetite is everything that surrounds why we eat. It includes hunger, but it's also that kind of fullness, the reward system, the more complicated bit of like seeing an amazing fresh cake or like a lovely smelling loaf of bread that's just come out of the oven versus yeah a plate of fruit but you're not really that hungry and the fruit doesn't look great it's physical hunger versus hedonic hunger what we call it that's a nice way of explaining how you feel um the relationship and the past and the emotions surrounding the food versus if you're physically tummy rumbling hungry totally and then they're regulated by completely different things the hunger is regulated by a part of your brain called the hypothalamus and that's really practical like it's monitoring your blood sugar your hormones like your hunger and fullness hormones leptin and ghrelin and it's assessing like does your body need it is there an energy keeps everything balanced in your body it's like looking at all the markers in your kidneys even with how hydrated you are and the body's doing something all the time exactly to regulate itself but we psychologically override that and that's the interesting bit isn't it exactly that is that we respond differently depending also on our genetics and I think that bit's so interesting.

44:01Yeah Giles Yeo always explains this very well he says there's always that person that will have that second slice of cake you know there's always someone that can and then you've always got that he makes it very comical because he's such a fantastic public speaker Professor Giles Yeo he then would say but then there's always that person that never has a second slice of cake and will get full up on the first you know oh who are these people that can just have one and stop at one and it's because we all carry these different genes and there is a link between a lot of research he does on the ob gene like the obese gene and it's shown that there are those people that will always have the second slice it's so interesting my kids are the most amazing example of it one of them you could give her like we went to stay with my mom and she often gives them little treats and she gave them some sweets and one of them she sucked on a sweet for like an hour and then yes i said to you i bet you anything we leave on monday morning and she hasn't finish the pack like she'll just forget about it she's someone first the other one ate the whole thing in three minutes yeah yeah i'm just saying it's young young yeah yeah younger one what does eat it all isn't that funny um but you're right we're so intuitive as children and we kind of we lose that as we go on because of different cues that we have with smell in society psychological reasoning and you know food is more than just fuel and that that's something they raise in the article they discussed that that food does bring us joy and it's also social and there's those different interactions that it can play as well but it's the cues around us in society this is why we call them obesogenic environments and yeah the neuroscientists call the hedonic hunger because when we smell something or see something we're drawn to it completely and that's why at home your food environment what we do in the clinic a lot of work is um you know that treat cupboard you've if you have a disordered relationship with food did you grow up with a treat cupboard in your house is that a habit you're still fulfilling now and to cope and then we have to look at their food environment and what enables and what could be helpful and not helpful that's so interesting do you recommend a treat cupboard no um do you know it's so interesting because there will be people that have it and not remotely fussed but if you are somebody that is currently really struggling with your relationship with food it might be an idea to do what i call i used to i used to do the servicing clinic i used to go over people's houses and do a kitchen detox I probably wouldn't call it that now obviously times have changed but yeah you'd get in trouble we can rebrand it like a kitchen sweep but you know what how you organize your kitchen can enable healthy behaviors and I would argue that it is a healthy behavior to have a treat in your house but only if that works for you at this current point in your relationship with food yeah that's so interesting so everyone acts differently of course we know sugary salty and fatty foods well UPFs of course rapidly increase glucose responses which means that you can also activate dopamine pathways in the brain as well yeah which I think is so interesting there were two things to me that was so interesting about this article is one is that reward system with the dopamine which I think is so important to understand so if you're eating let's just say you've got like a delicious bowl we're going to marinate some tofu we're going to pan fry it till it's crispy going and do like a spicy miso dressing we're going to have some lovely fresh avocado with sesame seeds I mean, so we've got a lovely bowl, but it's that's not triggering your dopamine response.

47:13No, that's what it means. You're going to eat it. You're going to feel full. It's going to be lovely. Yeah. Then on the other hand, we're going to have some, let's say, Krispy Kremes and you're going to have those and it's going to trigger a large jumbo bag of crisps in the evening. And you're just going to want to keep going. And that's not because you don't have willpower or there's something wrong with you. That's because your brain's going to keep getting these like, yes, it's engineered food to be hyperpalatable. Yeah. And your dopamine, like this reward system is like reward. I know give me some more but that is not also what's so interesting I remember writing about that we did this in the live show last year I think we discussed it on wilder scoop live the dopamine response cycle with the unprosed and you get that from scrolling as well yes you get it from scrolling but it's not the same as addiction so once again scientists are really trying to bring this link between food addiction or food noise and people are using these terms incorrectly and applying them to everybody on a blanket level whereas they have such deeper meanings in themselves and the dopamine reward cycle is not the same pathway as an addiction yeah that lights up the brain and i think we have to make that very clear to people but it is very valid yeah because you often you think oh is this why do i want more and more and more on phone it's like because your brain is like yes yes yes not because you're addicted but because your brain it's just lighting up these parts of your brain that are then pre-programmed to make you want more when you watch TV I think this is a really good challenge or just I think everybody would do it and you have a jumbo bag of crisps I bet you'd eat way more than if you weren't watching TV and you were sat with no distractions you were actually looking at each individual crisp it's also how we eat when we eat why we eat well it's like every mindfulness course I've ever done you start with like there's an exercise and you get you know a food so let's just say we've got a square of dark chocolate and you really look at the packaging and like what color is the packaging and then you open the packaging how does it feel to open the packaging exactly and then you break it off like how does and then you look at it it's like how does it look you smell it so you spend like two minutes where you put it in your mouth then you put it in your mouth and you like really feel it on your tongue and like gently suck it and you're like it's this experience of like obviously that's a very extreme way of mind but eating but it is a really interesting thing yeah of how different it is yeah and the other thing that makes a huge difference and that was the other thing we wanted to pick up on today was the impact of stress yes because we always talk about how stress that affects our appetite.

49:27And again, this was just a really nice look at that, where if you're kind of cognitively overloaded, you're fatigued, you're just stressed, your regulatory capacity of your kind of prefrontal cortex, that people call it like the CEO of the brain, the decision-making bit. That homicidases is off. Completely. And that's the part that's really involved in self-control, decision-making, as I said, executive functioning. That reduces when we're really stressed. Well, we see glucose responses. is your glucose levels can actually, so your blood sugar levels can spike when you're stressed as well. That stress can cause a response in your blood sugar.

50:01Exactly. So your reward systems remain completely active. So your dopamine is still like, yes, yes, yes, yes, yes. And your executive functioning is down. And so again, like your brain's demanding quick, reliable fuel. You want more of that because you want to be ready to run from your tiger because you're in this fight or flight mode. Your kind of executive functioning is down. And so obviously you've then got this stronger desire to eat more combined with a reduced ability to regulate that drive. So again, if you're really overwhelmed and you want to keep eating like way beyond being full and enjoying a tree, that's completely normal.

50:36You don't have a lack of willpower. That's actually how your body and your brain are designed. This is why I get infuriated with the narrative of supermarket shaming and the people that walk through it as if your life is that easy and simple that that one choice you make is going to change your entire life and the nuance here this article thank you so much because I really hope lots of you get a chance to just read it and be kind to yourselves because it is far from simple or that easy like people paint it out to be these influences. And I think as we were just saying it's this idea that you're like our biological drives like the way our systems are designed to be haven't really changed since our kind of hunter-gatherer past as we could call it.

51:20But then we live in this like endless food environment filled with things that will keep that like positive reward pathway going while your executive functioning is down and you're better, you're less able to kind of control things. And it just becomes really, really hard. Again, we always say this, like it's really hard to eat well. Good example. When I came in this morning, I've still got my present from Will. Ella's got me this cookie. I already actually had my porridge pot. So I made that executive decision actually to eat my breakfast and save my cookie for a bit later and look forward to it.

51:52But for some people, that decision would actually have been very, very different. They might have said, oh, slack off for breakfast. You know, I'm going to have the cookie. There's no right or wrong to what you do in that moment. But it goes to show how we individually face different things. If I was exhausted, I'd be like, hand over that cookie. Yeah, exactly. Yeah, yeah. I'm going to eat your birthday cookie. You know, the day when I said I had that worst commute and everything was going wrong on the day, it would have been that way around. For sure. Yeah. Anyway, it's a nice reminder that like willpower.

52:20I hate willpower. I just find it annoying. It's regulation, self-efficacy. It's involved with your self-esteem. It's so psychological. It's got nothing to do, and environmental, nothing to do with. Yeah, you're not a bad person. And I know this is just what's worked for me. But on a kind of general thing, I do think having practices in your life that give you a moment of kind of connection with yourself are so powerful. and that you know for me that's been sort of mindfulness and meditation and things like that but it is just even if it's a few minutes a day it's a moment just to be like hey I have a body I mean a mind and a breath and like I'm I'm here and you connect with yourself and it's so easy just to be a kind of headless chicken it's so true and find what works for you it's different for everyone let's move on to our what's trending in wellness because we have a big peptide update they're exploding since we first mentioned them on the podcast bigger than we thought this episode is absolutely jam-packed let's see if we have time to move on to homemade um asempic or we might have to move that to next week we will keep you updated okay peptides oh my god they're everywhere at the moment it's actually gone out of control i'm really glad we've got medics speaking up now about it and that's what we're going to discuss today because that's been all the headlines we've been saying it's been absolutely everywhere i've heard all these mainstream podcasts celebrities in LA particularly this has all really come from LA initially so peptides are short really come over here now though yeah it's really made it over here a lot of wellness influencers they are they absolutely are and they're short chain amino acids um short chains are these kind of building blocks of proteins that occur naturally in our body and people are essentially saying you can add a synthetic form like a supplement lab made peptides mostly injectables and the claims with them are quite wild you've got anti-aging or weight loss or muscle growth, recovery, injury, healing.

54:11It's actually huge. It is. It's so interesting. So I think also part of the reason, so just for what it's worth, insulin, for example, like that's a peptide and that's obviously a hormone that's regulating. It's life changing. People without insulin would be type one diabetics. You know, you're listening, you know. And everyone that's going on all the time to regulate your blood sugar levels, that's a great peptide that people use, obviously medically. Then we obviously have got your semiglutides and teresepatides. Teresepatide, yeah, it's a horrible word there. Which are the active ingredients, again, peptides in things like Wagavi and Monjaro, so your weight loss injections.

54:50Those obviously are synthetic peptides and they're mimicking these natural hormones. So peptides are, like in the case of insulin, life-changing, but also obviously very kind of topical at the moment with those weight loss injections. And so essentially we've seen this on like every single mainstream media. Even though it's unregulated. Yeah. And that's the thing. So there have been a few investigations. The Guardian, for example, did an investigation into different clinics in the UK that are prescribing these peptides and making potentially unlawful claims about these unregulated therapies. So we have got a regulator for medicine in the UK called the MHRA.

55:28They're now investigating this and whether these clinics are breaking the law because exactly this, they're marketing these peptides as like anti-aging recovery, performance enhancing, which you're not allowed to say. The American Medical Association, again, just published guidance. There was a piece titled, What Doctors Wish Patients Knew About Injectable Peptides? Again, highlighting their medical concern about safety, evidence and regulation. And I think evidence here is really important. Because we have no strong human trial data on long-term safety or effectiveness. Exactly. So yes, this isn't regulated.

56:03Obviously, that's a problem. Yes, there could be safety issues. Again, obviously a problem. But generally, I think the main concern here is like, it's not regulated. They could be unsafe. We're not saying they are unsafe, but they're not proven to do anything for you. So like you could be spending a wild amount of money using something that's not regulated and where you don't have huge long term data or almost any strong human data on whether or not they even work. Can I just to show you how little data there is, the only one that we could pull out is there's one very small human study with 10 to 12 people that said there might be knee pain help if you have some peptides.

56:41That is it. There's a popular peptide called BPC157, catchy name, that's often kind of marketed as support for like recovery. And that one exactly is a small human trial. 10 to 12 people might help knee pain. But it's because of TikTok. It's because of Instagram. It's because of. Oh, my God. I'm seeing it. There's this wellness influencer pops up last night. She's like, this is my skin before peptides. This is it after. It's called stacking, isn't it? Peptide stacking. I've seen that one going around. But I'm like, what else have you done? Have you done Botox? Have you done filler? Have you done like all these other treatments?

57:14Like, have you got a filter on? I mean, what are we selling people here? The Wall Street Journal recently described peptides as all the rage. So in places like LA, testimonials, yeah, are flooding. It's all anecdotal. Remember what we say on the Wellness Group. It's a red flag if someone say this is what it looks like for me, like Ella just said. It's a farce. One thing can only do so much, generally speaking as well. But as she's saying, like Wall Street Journal, Guardian, all of these publications, the American Medical Association, the MHRA, all of these people are saying these huge bodies of like doctors being interviewed, big medical bodies are saying these are not studied.

57:54These are not regulated. Do not take this. Well, it leads on from the NAD plus conversation that we were having as well. I feel like that was the first like home injectable situation. Well, it was after the salmon sperm, I think. Do you remember people were putting salmon sperm in? I actually have friends that have done that. And I remember discussing it because it really makes me nervous. The thought of anything going under your skin that you don't know where it's going to go. But I was intrigued. Obviously, I looked at it and thought, oh, maybe this will help with the bags and the bags when I've had no sleep.

58:23You know, all those sorts of things come into your head. But one listener has asked about NAD +, saying that two friends had started injecting it multiple times a week and claimed that it transformed their mood and overall well-being. And that's what we're seeing the whole time with all of these. I know NAD +, isn't a peptide, but I feel like it sits within the same family in the way that people are thinking about these things. You can't measure placebo. That's the problem. And what I will say is when you try anything new, you've always got a burst of optimism and hope. And there's loads of co-founding variables.

58:53But what's really, really clear is you don't know what happens once you inject something into your body, where it goes, how quickly it's broken down, the likelihood of even surviving anywhere, let alone reaching where you want it to go. And it's super expensive. How much is it, Ella? Clinics, for example, like in the UK, charging maybe£350 a month for a single peptide,£450 for a stack. £450. Again, this is what I call, it's nothing to do with public health. This is our wellness trend. This is just a money-making entity. and until I see any remote body of evidence, but then look how collagen took off without any robust evidence behind it.

59:29Really, when you do break down all the studies, they're not great. It's crazy. Creatine has research, but not collagen. So you could just be spending an insane amount of money on an unregulated product that's not proven to do anything. And we've got anecdotes. And also, don't forget, when people start doing this, you're often then prompted to do other things. You know what I mean? You've got a pep in your step, you're going to the gym, you're going to bed, you're eating well. And everybody was getting their lips done. Then they were getting them dissolved again. And actually now, because I was watching, because I'm a bit of an Olivia Atwood fan, her doc on Shout Out to Liv on the cosmetic surgery scene, because she's a self-confessed surgery fan.

1:00:07And she said that actually it never does quite dissolve once you have it. It is actually there for a long time. You can't dissolve. The way people thought they could just put something in, yeah, and take it out again. It's not that straightforward. I know, it's nuts. Okay, one more nuts thing. we'll do this quickly we can go into it in more detail if you guys want another day okay natural as mpick read true or false you know what another thing i get pulled into underneath the comments on and i love this morning it's one of my favorite like shows to watch i've always been such a humongous fan i just wish they get health professionals on instead of influencers to share any remote health info on itv we saw a prominent influencer sharing her tips for natural as M.

1:00:47Pichella. She basically was quoted saying that her MCT oils and things that you find in coconut basically signal and do something very similar to GLP-1s. It's not true. It is not true, I just want to say. And I've also seen recently books from health professionals, I don't know how this even got across the line with a publishing house, in their blurb saying that their foods and their recipes help stimulate or, you know, create a weight loss effect different GLP-1s. It's just a selling method. I get very frustrated. You see articles, Independent, for example, what to eat to mimic the effects of a Zempic without the jabs.

1:01:22Like there is just so much of this. Again, yeah, the Telegraph had something along the same lines, how the Zempic hormone works and ways to increase it naturally. And it's interesting. I watched the whole YouTube clip of this, for example, and like there was some bits in there talking about, for example, Dr. Zoe was talking about how like a high fiber diet it can help optimize your own GLP-1 production because the high fiber foods are coming all the way down into the bottom of your gut. Zoe does a great job but she knows she did say you know it's not the same. No exactly so you can kind of do things that boost your fullness which we already know like eating healthy fats and high fiber diets and good protein but you can't cheat it like you cannot make GLP-1 like you would if you injected yourself with it.

1:02:07The drug GLP-1 is a what we call a receptor agonist which means it mimics the hormone glucagon which is like a peptide one basically at a sustained rate so it makes you feel fuller for a very long time if add up to seven days it's actually been shown because of the strength of this medication no fats or mct oils or products or powders or anything is going to do that and the natural response from food lasts about two minutes hella that the food and the diet that we eat to eat healthily before it gets broken down by enzymes within our body and i love posts by some uh idris dr idz on social media that break down all of these types of things it's definitely worth a follow because the drug semaglutite can last yeah seven days you just cannot compare it in fact it's a thousand times stronger than the natural release of the hormone that we get from food you just cannot so for someone on prime time tv to sit there and say that so what we're saying is natural zembic false what you can do is increase your sense of satiety by eating a healthy, balanced, plant-rich diet.

1:03:11For two minutes. Yeah. No, no, honestly, no. Satiety is one of the key things we're lacking in society, to be honest. Like feeling positively full. Yeah. As in like a nice fullness where you're not thinking about food and you're not hungry. Because we don't allow ourselves to feel full. Do you know what's so interesting? The amount of clients I have that don't do full balance plates because they don't know actually how to feel full. Oh, I want to talk about this another day because I feel like I can get into this page. It's just a big discussion. Just one last thought on this. I'm going to make a note to talk about this next week.

1:03:43Is what I see a lot, and I've seen quite a lot on socials about this, which I think is quite good. Exactly that is we're like predisposed. I feel like a whole generation. We grew up with a special K woman. Yes. It's all like small, small, small, eat a 30 gram bowl of cereal for dinner and you'll lose weight and look great like a special K lady. Always have a little bit of hunger. Always feel a bit hungry. It's a very toxic trait. And it's almost like we don't exactly that. Like we don't almost quote unquote allow ourselves or know what it's like to eat that big bowl with like, as I said, you could have some like lovely miso fried tofu, but with some white, like lovely jasmine rice in there or some sweet potatoes and some broccoli.

1:04:15And you've got this lovely full meal. But people will do it without the jasmine rice, for example, because they're like, I'm doing the skinny version and then they're hungry. And it's not allowing yourself. I don't want to talk about this. Yeah, that's heavy. This is my core, core work is relationships with food. And it's allowing yourself the opportunity to feel full, to feel hungry, to enjoy the food. And that is something that we're... And add those carbohydrates to your plate. Goes back to the article, how we're conditioned to feel hungry. It's hedonic and psychological. But yeah, this was a good episode.

1:04:46Even if you don't think you're restricting yourself, are you kind of just like gently restricting yourself where you're like, oh, I'll just have a small bit of toast. I won't have a full bit of toast. Let us know what your feedback has been today. We're going to delve into this another time, everyone. Okay, but otherwise, we will see you on Thursday. We are talking about fruit sugar. We are talking, and whether that's actually bad for us, we are talking about smarter ways to hit 30 plants a week. We're talking about chia seeds and soaking them or not soaking them. Can you be healthy if you don't eat fruit?

1:05:13I'm excited about that. Some calorie tracking questions and calories in general. Lots and lots of stuff to get into. I'm so excited to talk about it. It's true. I know. We will be here Thursday, guys. We'll see you then. We can't wait. Bye.

1:05:34Spring just slid into your DMs. Grab that boho look for that rooftop dinner, those sandals that can keep up with you, and hang some string lights to give your patio a glow up. Spring's calling. Ross, work your magic. Did you know if your windows are bare, indoor temperatures can go up 20 degrees? Get ahead of summer with custom window treatments like solar roller shades from Blinds.com and save up to 45 % off during the Memorial Day Early Access Sale. Whether you want to DIY it or have a pro handle everything, we've got you. Free samples, real design experts, and zero pressure. Just help when you need it.

1:06:11Shop up to 45 % off site-wide right now during the Early Access Memorial Day Sale at Blinds.com. Rules and restrictions apply. You can't reason with the sun. Trust us, we've tried. This summer, it's time to put that angry ball of fire on mute. Columbia's OmniShade technology is engineered to protect you from the sun's harsh rays that can burn and damage your skin. The sun is relentless, but so is our gear. Level up your summer at Columbia.com to spend more time outside and less time slathering on aloe lotion. You're welcome. Columbia. Engineered for whatever.