In short
Episode topic: BitTensor subnets—Metanova (subnet 68) for decentralized drug discovery, BitCast (subnet 93) for creator “mining” of brand attention, plus a brief setup for Score (vision models). The hosts explain BitTensor’s subnet competitions: subnet operators set challenges, miners submit solutions, and validators score winners; staking (TAU/alpha) governs emissions.
Guests and backgrounds
Michaela Bazo and Pedro Penna of Metanova-labs.ai. Tom Blears, co-founder of BitCast Network (YouTube-based creator miners).
Key claims (Metanova)
Drug discovery is expensive (cited ~$2.6B/10 years) and failure-prone; Metanova aims to de-risk virtual screening by improving predictive power. Subnet 68 launched March 1 last year; miners run two incentives: (1) submit molecules binding to targets (example: serotonin) and (2) compete on chemical search algorithms. Starting dataset: 1B molecules; with 5 combinatorial reactions → ~65B synthesizable possibilities. “Virtual biotech” uses contract research organizations (CROs) for synthesis and wet-lab assays; they validate 50 candidates with partner Yalotain (Shanghai), expanding into nanobodies. They expect “interesting things” in 3–5 years and argue decentralized R&D can cut costs via CRO geographic arbitrage.
Notable examples (BitCast)
Miners are YouTubers who create videos from brand briefs; rewards depend on watch time (not raw views) to reduce “slop.” AI video attempts underperformed; creators (faces/stories) convert better. BitCast scales validation by checking 50–100 videos/day against briefs, targeting 100k/day. Current growth: 2M subscribers across ~50k creators; watch time and views up ~50–60% month-over-month.
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VOExploring BitTensor and its Subnets
0:45 to 3:48
Discussion on the BitTensor project and its associated subnets, emphasizing their diverse applications.
“It's in the late 40s or something, folks.”
Understanding BitTensor's Mechanism
3:48 to 5:00
Explanation of how BitTensor's decentralized network works, including miners and validators.
“So please welcome Michaela Bazo and Pedro Penna to the show.”
Token Economics in BitTensor
5:00 to 6:40
Discussion on staking, tokens, and their economic implications within BitTensor.
“So can you explain to me miners and validators as they relate to individual subnets?”
Drug Discovery Challenges and Innovations
6:40 to 9:20
Insights into the complexities of drug discovery and how BitTensor aims to innovate the process.
“And just like Bitcoin, there's a hard cap of 21 million tokens for Tau, correct?”
Molecule Selection Process in Drug Development
10:28 to 14:03
Discussion on the process of identifying and synthesizing drug candidates from a vast number of molecules.
“When we think about molecules, Michaela, that bind to serotonin, just stick with that example.”
Flexible Drug Development Process
14:03 to 17:02
Learn how a flexible drug development process can maximize options.
“and the validation that was generated in order for them to want to acquire or interact with this kind of novel IP.”
AI in Drug Discovery
17:02 to 19:16
Discover how AI can impact drug discovery timelines and costs.
“And we've all seen biotech companies long go public and then their phase three trials fall apart and then their stock goes to zero and then you kind of cash it in, right?”
FDA Trials and International Testing
21:48 to 24:46
Understand the implications of conducting FDA-compatible trials abroad.
“American responsive trials outside of the country?”
Innovative Drug Discovery Mechanisms
24:46 to 27:31
Learn about the innovative mechanisms for drug discovery and participation.
“Yeah, no, I would say the day we launched the subnet, it was more like.”
Iterating Incentives in Drug Discovery
27:31 to 28:00
Explore the importance of iterating on incentives within drug discovery.
“And Pedro, do you want to talk a little bit more about, you know, how to iterate on the incentives and the submissions?”
Show all 33 chapters
Understanding the Mechanisms of Drug Discovery
28:00 to 29:14
Learn about fast and creative methods in drug discovery and the agentic economy.
“they have a power of breaking, like, really well-published methods in a way that is insanely fast.”
The Role of Agents in Molecule Selection
29:14 to 30:56
Discover how agents are utilized in selecting molecules and patent checks.
“But when you get it right, you can get really, really good things very fast.”
Economics of BitCast: Mining with YouTube Content
32:25 to 33:54
Understand how BitCast allows YouTubers to mine crypto through content creation.
“was the idea of mining being something so far away from the proof of work, you know, Bitcoin OG setup that I'm familiar with.”
Ensuring Quality in Content Creation
33:54 to 35:51
Explore how BitCast ensures high-quality content is produced while rewarding creators.
“So then how does the validation then do validators determine if the views that are accrued to content made from briefs on BitCast are high quality?”
Brand Control vs. Creator Freedom in BitCast
35:51 to 37:39
Discuss the balance between brand control and creator independence in video content.
“So you can get waves and waves of content at the click of a button, whereas previously that would have taken weeks, months, maybe even years to get that many videos out.”
Target Markets for BitCast Content Creation
37:39 to 40:08
Identify which industries benefit most from the BitCast model of content creation.
“Well, it's a tool that can be used by brands and marketing agencies.”
The Booming Creator Economy and BitCast's Role
40:08 to 42:07
Analyze the current state of the creator economy and how BitCast aims to democratize it.
“And so we're leaning into those sort of tech versus with where we're sort of going to market.”
Democratizing Creator Engagement
42:07 to 44:16
Learn how Bitcast levels the playing field for smaller creators and enhances engagement.
“Beast probably has a premium on a per impression basis because he's Mr.”
AI's Role in Content Verification
44:16 to 45:48
Discover how AI tools are transforming the way video content is verified against creative briefs.
“So I guess, you know, as Mark said, AI checks the videos that are created.”
Growth Metrics and Market Demand
45:48 to 47:29
Explore the impressive growth metrics for BitTensor and the emerging market demand.
Brand Demand and Market Expansion
47:29 to 48:16
Discuss the brand demand within the crypto space and plans for niche expansion.
“If we get creators talking about tech, like I mentioned before, or AI, there's thousands of creators and there's massive, massive budgets there from centralized labs, the biggest companies in the world.”
Analyzing AI Bubble Predictions
48:54 to 53:04
Delve into predictions regarding the AI bubble and the factors influencing it.
“You can literally prediction market like a five-minute Bitcoin price changes, for example.”
Public Perception of AI and Technology
53:04 to 54:44
Examine how public perception of AI contrasts with industry insiders' views.
“you know, 76 % feels like a pretty strong wager at this point.”
Exploring SCORE's Vision AI Capabilities
55:18 to 56:00
Learn about the SCORE project’s goals and its advancements in vision AI technology.
“And we have had people from around the world on the show today, but it's always nice to see France show up, the home of Mistral, one of the world's leading AI labs.”
Exploring the Future of Vision Models
56:00 to 57:00
Learn how new vision models can enhance AI capabilities beyond text.
“you can download codecs, for instance, or code codes, and you can start building something.”
Challenges in Producing Effective Vision Models
57:00 to 59:10
Understand the hurdles in training and deploying vision language models.
“that people are bringing to score via BitTensor or how narrow are they, I suppose?”
Building and Tuning Vision Models
59:10 to 1:02:30
Discover the steps in building effective vision models and automation.
“Okay, so that's pretty much how you're trying to, like the first, you just build like a very, you know, a good data set of human annotated pictures.”
Practical Applications and Benefits of Vision Models
1:02:30 to 1:05:20
Learn about real-world applications and the efficiency of customized models.
“So it's a full agentic platform that knows exactly what you're trying to achieve just from a chat with you.”
Market Strategies and Partnerships for Growth
1:05:20 to 1:10:00
Explore how forming partnerships and community building can drive growth.
“Does that mean that some of the winning vision models over on the BitTensor competition will actually be different by the time they reach production on the customer scale?”
Teasing a New Partnership
1:10:02 to 1:10:45
Hear hints about a major partnership involving a tech company.
“And is that a technology company that you're partnering with?”
Commercial Growth Plans for 2026
1:10:45 to 1:11:21
Learn about the growth strategy for Manico and its subnet for 2026.
“We're getting loose because the show is wrapping up.”
Valuable Insights from Max
1:11:21 to 1:11:38
Max shares valuable insights on his work and its implications.
“If you want to learn more about what Max and his team are working on, go to manako.ai, M-A-N-A-K-O.ai.”
Wrap-Up and Future Plans
1:11:38 to 1:11:51
Reflecting on the discussion and future involvement with BitTensor.
“And we'll have you back on when you announce that major partner.”
Transcript
Automatic transcript. May contain errors.0:00Hello and welcome back to Twist. Today is March 25th, 2026. My name is Alex and I'm joined today by my dear friend Lon Harris. Hey! Lon... This Week in Startups is brought to you by Luma AI. Luma builds accessible, professional-grade AI tools for creatives. Try Luma Agents for free at lumalabs.ai slash twist. Every. For all your incorporation, banking, payroll, benefits, accounting, taxes, or other back office administration needs, visit every.io. And Lemon. Building a great team is essential to any business. Lemon is a marketplace of vetted, experienced engineers ready to take your company to the next level.
0:44Get 15 % off your first four weeks of developer time at lemon.io.
0:52How you doing? I'm doing pretty good. What day AO is it? What day after Claw is it? Is it, Alex? We didn't... It's like 40, 47, 48. It's in the late 40s or something, folks. We kind of lost track of that. Much like Lon himself in the late 40s and has somewhat lost track. Importantly, though, we are not going to be spending all of our time on Open Claw today. Instead, we are going to be drilling down even further into the world of BitTensor. We have three different subnets on the show today. Metanova, BitCast, and Score. I'm actually really excited about each one of these companies for different reasons, Lon.
1:25But I love getting a diversity of projects all part of BitTensor because it shows what the project can do as a whole. It's a really cool thing about doing, you know, we were so focused on OpenClaw for a while and it's cool. I still enjoy OpenClaw. I've bonded with my agent. But a lot of the OpenClaw projects are kind of similar. It's people doing kind of similar things. Here's how you can use your OpenClaw. Here's how you can make multiple agents. Here's how you can do this workflow and that. And the great thing about making a show about BitTensor is that every one of these subnets, they're doing different things with the core technology.
1:57It's one core concept or idea, but then you can use it in a whole lot of creative ways for all these interesting applications. And that's what I think is interesting about today's show is that it's three wildly different projects, but all built on the same kind of ecosystem. Yeah, drug discovery, social media for creators, and then also vision models for commercial applications. So we're going to be getting through quite a lot of things. But Lon, I think before we bring up our first guest, we should do a little PSA about our fun little devices that are listening to us as we speak. Yeah, we should talk about how we applaud plod.
2:28You may notice that Alex is wearing one on his wrist. I have one right here on my collar. These are plod pins. And all you do is you hit the button. It doesn't just record you and keep track of notes on everything that you said and the people around you said. It organizes them so that you can go through it easily later, figure out what you said, search through what was said. It identifies the people in the room with you. It gets to know the people in your life. So it really is kind of this magical device that takes interactions that you're doing throughout the day in your regular spoken, allowed life, and then sort of saving them for you and making them searchable and easy to look through later so that you never sort of miss anything in conversation ever again.
3:08Absolutely. I use it for less of that, Lon, and more as my personal scribe for when I'm like holding a child and I want to remember a thought, an idea, a task, a to-do. And I just kind of hit the button, drop it in, turn it off, and then I go back and I have kind of a list of things that I need to get done. An absolute lifesaver on my end. I'm a huge fan. And if you want to get a plod, you can do so. Go to plod.ai slash twist, P-L-A-U-D dot A-I slash twist. Use the code twist to save 10%, look super fly. And then Lon and I will give you high fives when we see you. Or online. Exactly. And we'll give you a virtual high five if you get applauded.
3:41If you send us a tweet, we'll follow you back or whatever the digital equivalent of that is. All right. Let's dive in. We're going to talk to Metanova, or as I like to call them, Lon, subnet number 68. So please welcome Michaela Bazo and Pedro Penna to the show. Just for folks out there who are less familiar with BitTensor and maybe don't know quite what we're talking about. So I don't know who wants to take this, but the way we think about it, BitTensor is a decentralized network that uses crypto incentives to reward individuals who contribute useful AI models, compute or results to task specific subnets.
4:14Thoughts, guys? How can we improve that? Tighten it up so everyone can follow along. I mean, I think as you were saying, day 47 after Claw, we're seeing that now it's humans and agents, right? So it's a marketplace for intelligence production. And there is a wide range of applications. Today, we're going to be talking about drug discovery. But as you were saying earlier, one of the things that makes it very unique is the fact that you can use these, this network to train any kind of AI use case or to develop any kind of digital commodity that you can think of from renting compute to vision to drug discovery.
4:47And we're all in it together and benefiting from each other's success, which I think is something really nice that's coded into the way that the protocol works. Now on that protocol point, I want to talk about the individual actors and players inside of BitTensor. So can you explain to me miners and validators as they relate to individual subnets? Basically, there's like three main actors, let's call it, in the way that each subnet works. You've got the subnet owner slash operator. In this case, it would be us who's basically designing the challenges. And then miners can be anyone from around the world or increasingly any form of intelligence from around the world that's solving those problems.
5:26So validators are then given a scorecard, let's call it, and basically selecting, reaching a consensus and selecting which ones are the winners for each competition. So these are like competitions that are running 24-7. Think about a hackathon that never sleeps that you can apply to any problem that you would like to solve. Pedro, tell me about staking and how Tau and Alpha tokens fit into this. Again, for folks out there who are just tuning in and learning this for the first time. So I think the best way to talk about staking is to see this as a way to vote on the subnets that you believe, right?
6:03Depending on the amount of stake that is flowing to the different subnets, the chain is going to define how much emission these subnets are going to be receiving. So it is also a mechanism for you to vote with your tau on the different, very different projects that are running on Bitensor or the 128. And just to clarify, emissions are, that's how people are getting paid. Like that the tau gets, or the tokens get admitted to them based on their work. And that's how their fortunes rise over time. Yeah, it works as also an incentive from the chain to everyone that is involved in the project. Got it.
6:40And just like Bitcoin, there's a hard cap of 21 million tokens for Tau, correct? Yeah, for Tau and for the alpha tokens that are linked to every subnet. And just to make sure that I'm tracking this correctly, each subnet has their own 21 million token alpha cap. Yes. Got it. Okay, explain the goal and economic structure, please, of subnet 68. Subnet 68 is part of this grand decentralized platform that we're building for drug discovery. why drug discovery is a very difficult, very expensive problem. Most people are describing it as being in a state of crisis with the average drug taking about 10 billion dollars and 2.2.
7:23No, sorry, 10 years and 2.6 billion dollars. Well, we see different estimates. And a lot of people are kind of shooting in the dark. It's a really hard question. There's a lot of points of failure. And so what we're trying to do is improve the virtual screening process so that we can make the best bets so that they don't even feel like bets so that we're de-risking what is really like the most asymmetrical bet that you could make and it has an impact not just like financially but also on people's lives so we launched March 1st of last year and it was first of all proof of concept of can we even do this in a decentralized way like nobody had ever tried to do that before and since then we've grown to have two different incentive mechanisms so right now our miners are doing two things simultaneously.
8:11They're either submitting molecules of interest based on whatever target we set for the competition. So we're like, hey, find us the most interesting molecules that bind to serotonin. And or they're competing on their second incentive mechanism that's focused on chemical search algorithms. Why? Because chemical search algorithms allow us to basically look within the possibilities of the chemical universe in a very flexible way. And we can plug to any kind of state-of-the-art model, and also keep certain information private that might be sensitive from our partner's perspective. Is the second mechanism a way to automate the first, or are they distinct?
8:49They talk a lot with each other. And indeed, we can see that miners can get a lot of inspiration from the second mechanism to compete in the first mechanism. Because you can actually choose. Do you want to open source or code that you're using to win in the first mechanism? Or do you want to keep it to yourself? So we have these two kinds of incentives and you can go for a more open source route of winning with the code itself. Or you can use this code to structure something that will really allow you to explore very, very vast chemical universes and then submit that. When you're launching a brand new company and designing your first product, you don't want to hire just any developer.
9:33You want the best, the best of the best, the creme de la creme. And that's why you got to turn to our friends at Lemon.io. We've had many companies in our portfolio work with Lemon.io and they've gotten great results. And Lemon.io is not just going to save you all the tedious legwork associated with building a team. They're also going to make sure you're getting matched up with top talent that fits within your budget. Here's how it works. Lemon has an experienced lineup of pre-vetted and curated developers sourced from Europe, Latin America, and the US. And they only accept the top 1 % of applications to this very elite program.
10:08So you know, you're going to be working with the best. Lemon IO will collaborate with you to help integrate your new hires into your team. So go to lemon.io slash twist and find your perfect developer or technical team in 48 hours or less. Plus twist listeners get 15 % off their first four weeks. That's L E M O N dot IO slash twist. Okay. When we think about molecules, Michaela, that bind to serotonin, just stick with that example. As a non-scientist myself, little economics, little philosophy, not a lot of chemistry and biology, how many possible molecules are we talking about? Like what's the library we're flipping through to then select from?
10:44So the number of possibilities, bigger number than I can even enumerate, and honestly, it's a theoretical combination of atoms. We're trying to focus specifically on what's synthesizable so that it is actionable, so that our miners are not just, submitting something that then we can't get tested in the lab and advanced into eventually like a drug candidate. We started off with a data set of a billion molecules, and then we layered on top of it five combinatorial reactions. So our miners are essentially recreating, like they're using these generative approach to recreate what it would be like to synthesize molecules in the lab.
11:20And that brought it up to about 65, we estimate 65 billion possibilities. That's a lot of possibilities. Can I jump in here, Alex? I have a question. So being a non-biologist, after this process is done, when we've identified strong candidate molecules through this system, what's the next step towards actually synthesizing them into like a treatment that we could sort of test out on people? It is indeed the synthesis of the molecules. So miners are submitting a lot of potentially interesting molecules. There is a heat picking process, that is the name, that you basically go through the best submissions and also consider a few other parameters.
12:01So like maybe a molecule could work really well, but you have evidence based on the chemical structure that it could be super toxic. So you're not picking that one for synthesis. So during the heat picking process, we consider a lot of other parameters to pick the ones that really go for synthesis and then wet lab validation that it is doing what it should be doing because every model will have some level of success but it is not perfect but it is so much better than testing billions of molecules in the world so the so after the the candidate molecule you've discovered it passes is the test. It's not toxic.
12:39It's worth trying to. Do you send it off to a lab? I mean, what's the actual next step in the process towards getting these drugs made? Yes. So we operate as what is called a virtual biotech. That means we are running with a very lean team, focusing on increasing efficiency and avoiding a lot of overhead for running internal wet labs. So there are companies called contract research organizations. They're specialized in synthesizing what you want them to synthesize and then testing those molecules exactly in the assay that you want it tested. That is how the core format then evolved. And that's something that you guys are taking on inside of your company.
13:22So BitTensor to generate the possible candidates, and then your company then takes those out to a CRO and then runs the test to see if they are compelling. And then at that point, Pedro, would you sell it to a different biotech company? Would you manufacture it yourself? What's that final step look like? So there are multiple paths that you can follow. Since we're talking about a process that is very long and very expensive, it is a game of the risking the assets and generating IP. So you're creating IP along the way and risking the potential drug that you are creating. So there are multiple points where you can be interacting with the industry and they might be interested in, for example, licensing of assets at earlier or later stages, depending on how interesting is the target, the indication and the validation that was generated in order for them to want to acquire or interact with this kind of novel IP.
14:19So if I can add, basically, the core motivation was to support our own R &D process, but we specifically or very intentionally build something that is completely flexible, target agnostic, so that we could also become a gateway for anybody else's drug development process. So it's very flexible, allows us to enter into any kind of co-development or even offer screening as a service. We have one partner who's based in Shanghai, Yalotain, and thanks to them, we're expanding beyond just small molecules into another therapeutic class called nanobodies. and together with them, we will be validating 50 of the candidates that are coming out of the out of the summit.
14:59So it's really about maximizing shots on goal. Okay. Can I ask about that? Because, and this is going to show my ignorance of the actual science at work here, but let's say there's 65 billion possibilities. You guys are looking for serotonin binding, say, and people compete and compete and compete and they find the best possible molecule for it, haven't you solved the problem? Why do you need 65 different candidates? Does this narrow to a single molecule or is there still going to be a range at the end for different variations in use? So that is the thing. You can go up to a point in terms of prediction if your asset is going to be efficient and safe, right?
15:40In some cases, you are going to need to test it to really be sure in many kinds of assays. So the idea is that you can if you can improve versus what would be random, there are a lot of gains that can be made and you can truly accelerate getting to cures. But as of now, I don't think there is any kind of approach that can get to the exact molecule from the first moment. It does need refinement along the way. You got to start giving it to people and seeing if they get sick. Right, but also it's like each person may respond differently. So the goal ultimately is finding something that's safe and effective for broad populations.
16:27Or at least that's usually how, I mean, there's also a whole future in which we're like delving a little bit more into personalized medicine and we deviate from that. But at the current time, what we're trying to do is find things that are safe and effective And commonly, they describe this process of drug development as like a funnel because you're essentially losing options along the way as you move from cell lines to animals and eventually humans. And what we're trying to do is improve the predictive power of step one so that you don't have to go three steps in and figure out that you've been wasting a bunch of time and money on the wrong thing.
17:02And we've all seen biotech companies long go public and then their phase three trials fall apart and then their stock goes to zero and then you kind of cash it in, right? Exactly. Yeah. We're always hearing about like, oh, they're they're testing a new Alzheimer's drug. We'll see. You know, that's it's always this sort of very hypothetical. Speaking of hypotheticals, I have one. So to me, it feels like we're going to use AI to make new drugs. It's going to cure all of these diseases like diabetes and depression and cancer. that's like the cornerstone argument for the AI optimism. Like Americans are very down on AI.
17:34We keep telling them like, no, no, no, you don't understand. We're going to cure these diseases. What is in your mind, because you guys are sort of on the cutting edge of this. What in your mind is the timeline? Like when are we actually going to start being able to offer people therapies that were developed by AI so we could start to actually make this argument for real? So we have a few assets developed using AI in late clinical trials right now. So we could be seeing this earlier than we imagined. But the thing is, even though for you to prove that something that takes a long time and a lot of resources is working, especially when they're doing this the first times, it will take some time.
18:14Sure. Yeah. How much is some time? Oh, I don't expect it to be tomorrow. I'm just curious. In your mind, is this a, you know, in the future we'll be dead, but our grandchildren will be fine? Or is this like five years? No, I think we'll be seeing some interesting things in the next three to five years, considering everything that is being developed right now, and that is undergoing clinical trials. Wow. It is becoming kind of the standard to go for these kinds of techniques because, again, it is truly, truly expensive. So if you can improve in any way, this is really relevant. You can bet more.
19:00That's a perfect segue to my next question. Michaela, you mentioned 10 years and$2.6 billion to get a drug to market today. How much do you think that can be reduced using Pedra's three to five year timeline? do you think it could be five years and 1.3 billion could it be one year and 100 million like how far can we compress the time and cost to get new drugs to market this is where people are gonna be like do not throw a number because then we're not being accurate so i'm gonna i'm gonna refrain from captain from falling into the honey podcast you're allowed to just rip no one's gonna no i'll tell you some things i'll tell you some things yeah but also it's like we need we need to be rigorous or else like everything falls apart like do you want a scam we can scam but that's not what we're here for.
19:42What I can tell you that's really interesting is there are many things to accelerate. So we are a decentralized company. We are decentralizing not just virtual screening, but also the whole R &D process. And that means we think that we can do geographic arbitrage, cut through red tape, accelerate timelines and slash costs even further by choosing the right place to get the tests done by working with CROs. And for example, there was like a very exciting news a few years ago from a treaty between the Brazilian Health Department and visa and the FDA, because the FDA is still kind of the gold standard for drug approval and like the gateway into the largest like addressable markets.
20:24I can't tell you exactly how many years, but we know that, I mean, the clinical trials done outside of the U.S. drastically, reduces the budget, right? And if we can prove or if we can work in locations and with partners that don't compromise the quality of that testing process, that means maybe we can get the best of both worlds, right? So much of what we do here on the pod is about tactical and practical tips for founders. Basically ways for you to save time, save money, and get those chores done and reduce stress in your organization so you can focus on what matters most in your business. And here's a crucial one, delegating your back office administrative needs to a trusted partner like Every.
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21:54Just to make sure that I'm getting this right. So the FDA would accept results, say, from Brazil in this case, so you can go faster and more cheaply, but still get that gold standard seal of approval? Yeah, yeah. For some specific cases, we're seeing that this is where they're moving to. So I think it is... That's really encouraging. ...very reasonable to imagine that we're going to have this substantially more integrated and more common as we are getting to harder and harder diseases to tackle. I want to go back to bedtensor because I have one more question I want to ask about this. When I think about other subnets like shoots, for example, you know, providing compute, it's pretty easy.
22:33It's kind of fungible. People can just bring it. When I think about finding the right molecule from such an enormous set of possibilities, it feels like a different type of challenge to me. And so I'm curious, how many people out there are potential miners for Metanova? Is that a large group of people? Is this a problem that a lot of folks can attack? Or is it a relatively small number of people with a niche set of skills and information? I think the beauty of this system is that in the way that we have designed this problem is that you don't need a background in this field to participate in it.
23:08We've like reduced it to a search problem and that's actually led to very interesting results. So, for example, in our second incentive mechanism that's focused on chemical search algorithms, we saw somebody apply an optimization strategy that's never before been used in drug discovery, outperform a well-established industry technique across a number of targets, across a number of challenges. So we're seeing innovation in being able to change the competition format so that it can allow for this cross-pollination of ideas. Right. So going back to this, we need like a hybrid intelligence model to truly automate science.
23:49At least that's kind of where we're coming at it. And that means humans, experts and non-experts, agents and machine learning competitions that are hosted within Bitensor. If we can bring all of these things together, I think we are in the most solid ground to really accelerate the timelines and hopefully get surprises along the way. You know, we want to be cautiously optimistic, but at the same time, it's truly fascinating to see how much the world has changed since we launched the subnet. Like, everything's truly accelerating and we're seeing like amazing new tools being developed that totally change and force us to update our priors on what we believe can be possible.
24:27So BitTensor then has been the right choice for your company to democratize this work that underpins your future commercial prospects. Absolutely. Absolutely. Has it met exceeded expectations? I'm curious about like the enthusiasm you had on day one when you launched the subnet to where we are today. Better than expected? Better than expected. Yeah, no, I would say the day we launched the subnet, it was more like. Like, so it's interesting to have a workforce that, A, you don't know, and that is in an adversarial relationship with you, right? Like, it's not your usual office job. Like, the miners are actually quite unruly.
25:06So when you first launch incentive mechanisms, there's this warm-up period or this learning curve where they're trying to exploit you. They're trying to break your subnet. They're trying to game it, yeah. They're trying to game it. But there's actually, we noticed what we thought, you know, it's actually a feature, not a bug. So one thing that we found is that at the very early stages, what the miners were doing is they were finding the shortest path to a reward. And that meant that they were pointing to us the areas of low confidence in these state-of-the-art models because they don't have the same bias.
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25:38Right. And everyone else is training this, like in a private company that's trying to protect their valuation or in a research institution that's trying to publish good results. Our miners do not care. They want to make a token. They want to earn their tokens. And that can that can be, you know, a little tense and it can be a high stress environment. But ultimately, it can add resilience to the system. And if we can use that information to build something that has a higher predictive capacity, then I think we have a competitive edge in technology that we're training in a decentralized way that goes beyond just resource efficiency and tapping a global network of like really cracked engineers that are competing for.
26:19your token and for creating increasingly more valuable commodities, the true challenge becomes, can you program their behavior and align them in a way that generates valuable inputs? Yeah. You're productizing the unruliness, essentially. Yeah. And we believe the answer is yes, but it's a very dynamic system. But at the same time, wouldn't it make sense that a dynamic system would be the one that would create the most interesting technology. We're constantly responding to what they're submitting and being like, actually, we need to steer them this way and that way. And that means that ultimately, we have a living mechanism that can learn from the results from their behavior, and you can tweak the incentive so that they can yield different results.
27:09And that's very interesting in and of itself outside of the context of drug discovery. Do you need like an in-house economist to help manage the stuff that you're describing? I'm not even really kidding, Michaela. Like, to me, it sounds like you could have, you know, just get yourself a Chicago School PhD in econ and set them loose to tune and tweak and improve your economic incentives on the platform. Oh, I thought you were pitching yourself for this game. No, no, I dropped out of economics. You're a co-host. I mean, this is actually more like, Pedro's, I think, best suited to really comment on this because, you know, he's constantly tracking submissions and also recently recruited an agent to help look at some of the work that we've been getting from our miners.
27:51And Pedro, do you want to talk a little bit more about, you know, how to iterate on the incentives and the submissions? Yeah, no, it is actually very, very interesting because miners, they have a power of breaking, like, really well-published methods in a way that is insanely fast. and that is actually really really good because in many cases you just don't know what are the potential problems in your scoring function right right with what you're using to to do the predictions and so after you know that and you understand how to consider that um in the in the structuring of the challenges then it really it really goes well right but it is constant iteration It means we need to be checking what is being submitted to be sure it is aligning with the long-term value generation.
28:45This is absolutely our responsibility. At the same time, a lot of interesting things come from that. We started with one mechanism. And then the second mechanism was also a way for us to increase the competitiveness and kind of have everyone sharing their super interesting new approaches to look for molecules. And so you need to be creative on how to do that. But when you get it right, you can get really, really good things very fast. The way we are going to be plugging all of those things with the agentic economy in this wave of agents is also something very interesting because we are considering what is the best way to also make the outputs that we are creating integrated with agents because we do envision a lot of agents doing a bunch of applied science in the next few years, right?
29:48So we need to be able to integrate all of that. We are implementing some very, very interesting agents. There are some that are already in production. and, for example, helping me select the molecules that are going for synthesis or helping me check which ones might already be covered by patents, so not ideal for us to explore. This is really, really interesting. Yeah, I was thinking about some combination of auto-researcher from Andre Carpathy, my local OpenClaw setup, and then somehow doing useful work for Tau subnets or BitTensor subnets. I feel like I should be able to put my agents to work somehow to help with something here.
30:32So I wonder in time how much the ratio of humans to agents doing work at the minor level will shift. But Lon, that'll probably take a couple of years, I think. Mine's still just writing my tweets for me. Oh, well, that explains why they're so bad. The URL is metanova-labs.ai. You can take a look at it. Michaela and Pedro, thank you so much for coming on. I appreciate it. And I think I fully understand it. So rock and roll. You guys are the best. Up next from Subnet 93, we've got Tom Blears. He's the co-founder of BitCast Network. This, Alex, is a subnet where miners compete over who can generate the most social media views for a brand, a product, an individual, whatever your project is.
31:15This is a way to crowdsource user-generated content about whatever you're working on. Tom, thank you so much for being here. Thanks, guys. Really good to be on. AI models can produce stunning, realistic video, but going from an idea to something polished enough to publish, that still takes a long time. Even the pros spend half their time managing tools and jumping between models rather than actually creating. But now there's Luma and Luma Agents. Luma's not just an aggregator of third-party models. That's the future of AI. They know the best tools for that task. If you're doing a website, if you're doing a promotional video while you stay focused on bringing your vision to life.
31:53And Luma's just introduced their powerful new model, Uni1, which understands your full context and turns your original idea into a beautiful finished work. Text to image was just a demo, but reasoning to image, that's the real product in the future. You're not just typing in a prompt and walking away. Luma puts you in the director's chair. Luma's going to 10 extra creativity, not try and replace it. To try Luma's agents for free. Go to lumalabs.ai slash twist. That's L-U-M-A-L-A-B-S dot A-I slash twist. The thing that really grabbed me about BitCast when I was prepping for you coming on was the idea of mining being something so far away from the proof of work, you know, Bitcoin OG setup that I'm familiar with.
32:37So before we dive too deep into this, Tom, can you explain just the economics of BitCast and how the value and tokens flow? You're spot on. We're very unique in a way on BitTensor and our miners are YouTubers. So people essentially mine crypto with YouTube content. And the platform, we can go into a lot more detail on how it all works, but essentially takes care of automating the whole process from creating the briefs to actually measuring attention. Yeah. And the more attention that you can generate, the more rewards that get issued to creators. This was so after years of working on YouTube, working for creators, working on YouTube channels, the brand deal advertising part of it is such a huge part of the job.
33:27And it's such a time suck. And it's really kind of like there's so much uncertainty about it. You get like a little brief from a brand. Here's what we want the video to be. But then you're always sending it in and you're kind of waiting on pins and needles. Are they going to like it? Are they going to reject it? Did I miss saying the one sentence? And so I love the efficiency here of figuring out a model where it's like, here's exactly what we want in your video. And if you do a good job and you hit these three metrics, you get a little tau out of it. Okay. So then how does the validation then do validators determine if the views that are accrued to content made from briefs on BitCast are high quality?
34:05Tom, talk me through how you ensure that people aren't just putting out slop and trying to stick 15 views together 100 ,000 times to make money. Yeah, 100%. So when we release a brief, essentially, that will say a video needs to talk about point A, B, and C, as an example. And then creators create content that matches that. And they're basically scored on how much watch time. It's nothing to do with views. It's to do with how long they can keep people on the videos. So that comes down to obviously the competition here is to make the most engaging videos possible, get the information across as accurately as possible.
34:43And the more you can keep people watching, the more you will be rewarded. Okay. So it's length of time. Okay. So it's not like if a video is made by AI versus having people in it, you're not really that concerned about it as long as the watch time is keeping up with the correct metrics. Yeah, and interestingly, when we launched the subnet at the beginning, Michaela touched on it earlier about people trying different things and exploits, et cetera. We did have a lot of people creating AI videos, but it just generally doesn't seem to convert very well. People like to see people. They like to talk to people.
35:20So that has been experimented with. I don't know why the future is going to land us with that. But yeah, it's generally people bringing stories, bringing information to life and putting their own creative twists on it. Does the system result in a little bit less brand control? Because in the scenario that Lon mentioned, no one wants to submit their video or a piece of content and then wait to hear back and then maybe have to do it again. That process is terrible, but it does leave kind of a lot of the power authority in the brand, Tom, in their hands. Versus in BitCast, it feels more like the brief is put out, people react against it and then they earn a share of emissions via view time but the brand in question has less control over over what goes on does that worry them the camp it all comes down to the design of the brief doesn't it so the briefs um they do go through all the points that you want creators to go into detail on um alongside the brief there's an information pack so if the brief says talk about point a b and c of how they achieve this the information pack will give you all that information so that's all accurate information provided by the the brand um but then we're also leaning on the fact that these creators are these are very very well established creators they have their own reputations and they are leaning on and they are they are providing their opinions so so like all of that combined it results in really really good uh videos and we've not had any instances where people haven't been happy with the videos oh yes the whole i mean this technology yeah this this technology um it really what it can achieve is is not really been done before so we can now get you know hundreds if not thousands of videos created or the push of a button and if you think about the admin saving on that it's all validated against the creator against the brand's messaging.
37:14So you can get waves and waves of content at the click of a button, whereas previously that would have taken weeks, months, maybe even years to get that many videos out. So it's extremely powerful in that regard. So do you think this is going to lead to an overall increase in brands that wanted to work with creators and creators that can monetize their videos? Or does this more replace the current ecosystem and marketplace of creators and brands we have? Well, it's a tool that can be used by brands and marketing agencies. We're not here to completely replace the way that people do things. But it's a very, very effective way of generating a lot of content with reducing all of the admin.
37:53Yeah. And what industries are the best for that fit? Because I presume that if you're selling$2 million watches, you don't really want a mass audience with a very target niche audience, but there's probably a lot of stuff that does fit into this. So what's the best or what's the current most popular brand type that want to use BitCast? So currently, we're working within crypto, we're working with a lot of BitTensor subnets, and we're starting to work with some exchanges as well. And we're still developing the software, developing our AI that analyzes all the videos as they come in. But beyond this, we see sort of AI, general ai and general tech is very very good niches to go down so if you've got a new product release let's say you're microsoft you've got a new product release you can get loads of targeted youtubers to give a breakdown on how that product works again you can sort of apply that to most industries really but you are right like a unique uh watch um really high ticket item might be more aligned to go in with your leonardo dicaprios but if you want to get information out and breakdowns and demos of how products work and you want to get a lot of people to understand you've got a new feature, you've got a new product that you're releasing.
39:07Yeah, we can release that into a targeted pool of creators to bring that story to life. I mean, the one that jumps out at me immediately is like fast food. Like every time a new fast food restaurant introduces a new item, you see the wave of people who've obviously been compensated on Instagram to like go try it out. Like, hey, I've got the new BK chicken, whatever. and like i feel like that is the sort of thing that this was just like purely designed for you could just think burger king could just pay for thousands of people to sort of pretend to enjoy their new chicken sandwich at once whoa whoa whoa you don't like chicken sandwiches what the hell not for burger king someone grew up fancy all right sorry talk would burger king be a good fit for bitcast if they wanted to promote their new chicken whopper probably not right now um But no, we're keeping it to quite sort of technological sort of topics at the moment.
40:01If you think about what YouTube is really good at is sort of putting faces behind names and explaining how things work. And so we're leaning into those sort of tech versus with where we're sort of going to market. We're doing it on This Week in AI with demos. That's YouTube loves a demo. YouTube does love a demo. know what is the health of the creator economy writ large uh there was a wave of startups some number here three four five maybe tom when the creator economy is going to be this big thing and everyone thought that there's going to be you know 10 times as many creators but it seemed to kind of end up like the power law like the top one percent made 80 of the money and things seem to have gotten a little bit quieter so i'm not as familiar or aware today of just how strong the creator economy is that bitcast is going to tap into to create the videos if that makes sense so the creative economy is absolutely booming um i know what you're sort of touching on there with the top one percent taking a lot of the revenue which is a problem that we are solving i'll come on to a minute but the the creative economy is absolutely booming um and the i mean i think the projections at the moment is that it's about 250 billion dollars worldwide um it's growing much faster than any other ad medium, so paper clicks and traditional ads that you see in newspapers, etc.
41:24It's growing much, much faster than any of those, and its return on investment is much, much higher. This all boils down to trust. You trust the people that you follow and you lend your attention to, if you will. But on your point about the top 1 % taking a lot of the earnings, So that's actually a result of the admin behind launching marketing campaigns with creators. So if you were to go and work with, let's say you had the budget and you want to go and work with 10 creators. The effort to go and get 10 creators to talk about your brand, run through the brief with them, get them to understand what you're doing is very onerous.
42:06so you're only going to go for the top creators because your bang for the buck on the admin is way better spent however what bitcast actually unlocks is is really powerful when you think about it because we now have removed all of the admin and the return of investment and the actual trust and engagement for smaller creators is much higher than big creators it feels a lot less commercialized now you can activate all of these creators at the push of a button so you're actually managing to tap into that 99 of creators with your same budget and um yeah it's it's it's it's a theory and it's a sort of point that we're sort of leaning into of democratizes who can participate who can make money from being a creator and it probably also evens out the payments a little bit because if it's just done on view time to your earlier point versus, you know, Mr.
43:04Beast probably has a premium on a per impression basis because he's Mr. Beast. So it makes it more fair as well. Lon, this seems very democratic to me. I like it. Yeah. I mean, I think you're hitting the long tail of creators. There's a ton of creators out there who have, you know, a few thousand, a few tens of thousands of really dedicated fans who will listen to anything they say and who if they started to give brand messages would probably pay a lot of attention and if you sort of cast a big enough net over that group you're still talking about millions and millions and millions of people i think right now everything is so consolidated on like you know the mr beast of the world the people who have those incredibly high profiles a system like this is amazing for like scooping up a whole bunch of those people that are in the middle you know they're not they don't have nobody following them they have a lot of people it's just not record-breaking competing at the very top of the charts numbers another thing that we can actually do which is um very very novel and i think we are the only people in the world that can actually do it is that our system can work with obviously any creator in any place but any language as well so we could have a hundred different languages all on the same campaign because it's ai that validates what they're talking about it it's language agnostic so um as we sort of build this up and introduce much more create many more creators um and as we grow into other software verticals like the the reach that we can do would possibly take multiple teams all speaking different languages all speaking to different creators so the time savings on the admin side are yeah it's the ai verification though that that i keep getting a little bit stuck on tom because if i'm thinking about a creative brief to me that's a very human document because, you know, humans are trying to talk to other humans through the medium of a creator.
44:51So I guess, you know, as Mark said, AI checks the videos that are created. How strong is that? Are there problems with it? Have you improved it? Is that an easy problem that I'm overestimating the difficulty of? That's essentially what we've been learning and that's what we've been developing. And, you know, that's part of the benefits of being on BitTensor. We've got access to some of the best AI tools in the world. So, yeah, we are always iterating our process. And the video, like at the moment, we're sort of checking, you know, 50 to 100 different videos a day against the brief. That system needs to scale up and we're getting it to a very, very stable position now where we could scale up way beyond that.
45:34But, yeah, it's a problem that we're working on and we're getting really, really good results now. and you know it has to it has to scale up to sort of 100 000 videos a day really and based on what we're seeing at the moment we're getting close to that i want to close with growth because when you guys wrapped up your 2025 you said in your substack post uh that in the last two months of the year i think you said your uh hours watch was up 60 percent views were up 56 percent in the same period so a lot of growth going into 2026 how has the new year treated you how's q1 gone really really well so i think we sort of flipped the switch over new year so we were developing a lot last year we flipped it into sort of scaling up the network um we're now our creator network's now at 2 million subscribers and 50 50 different youtube creators um but we are accelerating about 40 50 percent a month on creators and our watch time and views are yeah about 60 50 60 percent month on month at the moment and that's no sign of slowing down um in fact we are getting creators every every day trying to join the network is there enough brand demand inside of your current niche because you're targeting a particular slice of the market start is there enough brand demand there to support that many creators or do you need to start opening up to other niches internet technology sometime soon the whole of last year we were just working with bit tensor subnets um the start of this year we decided to outreach and we've started working with one of the biggest exchanges in the world we're now in conversations with many others and um yeah so we're now starting to attract capital from outside of bit tensor and the demand for this product is um yeah there's a lot of demand there's a lot of custom out there just within the crypto industry.
47:26Obviously, move that out beyond that. We've got creators. If we get creators talking about tech, like I mentioned before, or AI, there's thousands of creators and there's massive, massive budgets there from centralized labs, the biggest companies in the world. And they're going to be very interested in what they can achieve with BitCast. They're coming for Oliver's AI demos. Oliver, look out. You've got some competition. Well, when you are ready for fried chicken demos, that's when I'll be ready to jump in. That's my expertise. Tom, thank you so much for joining us. BitCast.network is where to go if you want to check it out and become a creator, become a miner, become a validator, just learn more about it.
48:06Tom, thank you so much for being here with us. We appreciate it. Subnet 93, everybody. We love to see it. We love a numbered subnet, don't we, Alex? We love a numbered subnet. Well, you know, it's okay. I have a lot of thoughts about this. One, there's a lot of numbers used in company names in China. So something that I've become more accustomed to just as time goes along. Also, it just strikes me as slightly science fiction to have like a series of number subnets in this way. And so, you know, I'm a big nerd, Lon. And so this actually kind of works for me. It does feel a little sci-fi, like a community where everybody is identified by their number.
48:42It's like the prisoner, but for tech. Before we jump into our interview with Scorelon, I want to bring up my new favorite polymarket of all time because often polymarkets are a little bit binary. You know, like, okay, will Elon Musk tweet five times before noon or whatever it is. They're so specific now. They get so specific. You can literally prediction market like a five-minute Bitcoin price changes, for example. But this one is called AI Bubble Burst Buy. It's a question about when things will turn, if they will. And if you're watching the video version, you can see there's a 24 % chance, according to the Sharps over at Polymarket, that it'll happen this year.
49:22But what's interesting, Lon, is the terms here. Talk us through it. We always say you got to look at the rules. And I think this is maybe, of all the Polymarkets we've ever looked at, the most important to look at the rules. Because just will the bubble burst? It's like, well, what does that mean? How are we defining it? And here's how they're defining it. So the AI industry will be considered to have experienced a downturn once at least three of the following events have occurred within 90 days of the time frame. So by December 31st, 2026, 24 percent of the people on Polymarket are betting that three, not one, but three of the following things will happen.
50:02And they are NVIDIA's closing stock price is down 50 percent from its all time high. The iShares PHLX Semiconductor ETF, that's S-O-X-X if you're looking at the stock ticker, that closing price is down 40 % from its all-time high. OpenAI or Anthropic declare bankruptcy. OpenAI gets acquired. The rental price for an H-100 chip falls to$1 or lower for five days straight. or some of these major AI hardware suppliers, their stock price goes down 50 % from its all-time high. That includes Taiwan, TSM, ASML, Broadcom, Supermicro, the big players in the chip world. So I could see one of those things happening by the end of this year, but for three of those things happening by the end of the year, it strikes me as pretty remote, more remote than a one-in-four chance.
50:59Well, that's what you and I think. But, you know, people can take the other side of that bet if they want. But what I appreciate here about this is if three of these things happen, I think it's actually very fair to say, yes, the AI bubble has burst. So much as there was a bubble to begin with. So, like, this is a really well-framed bet. Now, I don't think that we're going to see OpenAI or Anthropic declare bankruptcy because they have – It seems impossible, right? Like they would have to go on like a wild, insane, like Vegas spending spree. They'd have to buy Guatemala. Yeah. Like, I mean, I don't know.
51:33I don't know how that could happen. So that's not going to happen. Now, NVIDIA's share price losing 50%. I did the math before the show, so this is probably a little bit out of date now. But it's off about 15 % from its all-time highs, which is not that much given how bubbly that stock has been. Yeah. But to lose 35 % with the 75 % gross margins,$2 trillion in spending for its latest GPU, blah, blah, blah, blah. So I don't really see it. We're talking three fiscal quarters. We're not talking, like if it was 10 years from now, you know, anything could happen, but that's just not that long a time period.
52:01Yeah, it's not that long a time frame. Also, if you're curious, an H100 hourly rental today is about 750 according to the data source they're using for this bet. So to have it collapse to$1 would imply an absolute inference and AI compute collapse lawn. Yeah. Not super likely, I don't think, but the open air acquisition thing caught your eye. Tell me why. Well, I just, yeah, I mean, that one feels like a weird rule. Like, OpenAI being acquired, it could be a sign of, like, a collapse. Like, it's worth so much less now. Its value has plummeted. Everybody stopped using ChatGPT. Yahoo's going to pick it up.
52:36Like, I could, like, I'm kidding about Yahoo. But, like. I used to work for Yahoo. So, like, you know. But, like, but, you know, I could envision also a scenario where OpenAI gets acquired. And it doesn't necessarily mean AI is dead and over. It just means like another mega deal happened and two companies. It can be super bullish. Right. Someone buys it for three trillion. Then, I mean, Sam Altman's walking on the moon. Exactly. So that one struck me as kind of weird. But I don't know. Obviously, not financial advice. But overall, to me, you know, 76 % feels like a pretty strong wager at this point.
53:10You probably make up 24 cents on your dollar there. Yeah. But this is like, this is actually what I want people to use prediction markets for. And this is my old man yells at cloud thing. But like this is a hedge. If you have a lot of like exposure to like AI stocks, you could buy the other side of this contract and literally just hedge your hedge yourself. And that's super duper cool to me. That's that's the type of thing that I'm most excited about. from Polymark. I feel like there's a lot of culture. If you're inside the tech industry, the idea that any of this could happen by the end of this year is like, you sound insane.
53:46Everybody would be like, what are you talking about? It's just like we were just talking with Metanova. Things are accelerating. From the perspective here at this week at startups, things are moving faster than ever. This stuff is being adopted more than ever. Compute tokens are more valuable than gold, literally. Like, that's how people in the industry feel. So I think this is a lot of like, if you're outside the industry, you're like, I don't even use ChatGPT that much. If you're not coding, so you're not using Claude Code or you're not on Codex or whatever, you're not on OpenClaw. For a lot of people, everyday people, I guess it still seems like, well, this could all just go away at any time.
54:23For Elizabeth and Tech, that sounds crazy. It's like it's too embedded in our everyday lives for it to ever go away. the the average person has asked chachi bt to write them a poem four times at this point in time and that is not enough i think to get your feet let enough to learn how fast the water is exactly i think that's i think that's a big part of what we're seeing here is people outside of the tech industry wagering on this without really understanding how deep it goes already i want them to fire up cloud code and have it build them an app and then run it because i think if you once Once you discover that that's possible, then AI does feel like the old bicycle for your mind thing.
55:00Like, here's a thing that lets you go and do so much more. Anyways, all right, let's do our third interview because I'm stoked about this one. I did the pre-interview for this, Lon, and let me tell you, the technology is astounding. So we're going to talk to Score, or as we call it, Subnet44 over on BitTensor. Please welcome to the show. It's Max Septi. And critically, Lon, he is in Paris. And we have had people from around the world on the show today, but it's always nice to see France show up, the home of Mistral, one of the world's leading AI labs. Max, hey. Yeah, thanks for having me, guys.
55:32Definitely. Great to have you. Happy to be with you today. So let's start with the same question we're asking everybody. What is the goal of the SCORE project? And also, how do the economics work? Yeah, definitely. So the goal of our project is to literally give AI sites. So our subnet is building vision skills, let's say, for agents or human users to build vision AI apps. So the whole thing about, you know, via coding and stuff, it's really, you know, you just said it, you know, you can download codecs, for instance, or code codes, and you can start building something. And it's, you know, it's empowering, it's crazy, it's a beautiful experience.
56:11And we think that if we want to go a step further and go beyond text-based intelligence, we need to give agents and people the ability to build vision as well. I love that. Lon? I was just going to say, as somebody who has constantly tried to get his agent to watch YouTube videos and have them rely exclusively on captions or a transcript, I could not agree with this more. Like, I want my agent to be able to see the video, not just read what was said. Yeah, and you just mentioned Polymarket a few seconds ago. Imagine someone being able to stream something, like mention markets or even sports markets, and then get an agent to act differently based on what's happening on screen.
56:48This is the type of thing we want to unlock. Yes. But this brings up the question of what type of vision model are we talking about here? Because there's a lot of things you could watch. So how broad are the vision models that people are bringing to score via BitTensor or how narrow are they, I suppose? So it's exactly like your second question about, you know, what's the economy around the subnet? The economy is pretty simple. If you try to use a state-of-the-art VLM, which is a vision language model, it's actually quite accurate, but it's not built to run in production. It's built to kind of be very accurate on very specific things.
57:26And most of the time, to access computer vision, you would need to be an expert. You would need to know how to code. You would need to know how to train a model. And you would probably end up with something very accurate, but then way too expensive to run in production anyway. And this is like the biggest problem in vision at the moment. So the way we build our subnet is to actually distill big models into very specific and tiny skills. So then people can use them and can buy them the way they want. And instead of running them on very large GPUs, you mentioned H100s, for instance, they could run it locally on a CPU, which unlocks then a lot of vision use cases that were so far not really profitable or not really interesting from a unit economics perspective.
58:15So we are incentivizing our miners because now we all know the different terms around BitTensor. We're incentivizing them to take big models and to cut them into chunks that are working, for instance, for person detection, car detections, yada, yada, yada. Right. That's what I wanted to get into. Can I ask a sort of a doofus question, jumping off point, just before we go further? How does a VLM differ from an LLM just in terms of like the training process and putting it? I think we all have a pretty good conception of what an LLM is and how you make one. How do you train up a good quality VLM?
58:53So most of the time, and that's a bit of my background as well, I was working for a data annotation company like a few years ago. So you use human annotators to tell you, captures, for instance, captures were the best way to start building VLMs because you're using human beings to tell you if there's a bicycle within the image, right? I could spot a crosswalk like that. Yeah, like crosswalk now. Okay, so that's pretty much how you're trying to, like the first, you just build like a very, you know, a good data set of human annotated pictures. So that was the first step. And that was a big hurdle for us as well because we wanted this to kind of really scale, we had to find a way to create very precise data sets that could bring also what we call ground truth.
59:40So I don't want to go too much into the details, but basically if you want to validate something in vision, you actually need to know if miners are going to produce quality data as well. So you need to find a way to automate this process of annotating content. And that's a bit technical, so I can probably answer two more questions there. But just to your first point, you need to collect a lot of data so the computer would know exactly how a crosswalk looks like, for instance. And this is why, even before you launched the subnet formally, you were already getting partnerships with other companies to collect that data you needed, Max, right?
1:00:19Yeah, it comes from, I mean, there's two reasons around that. First one is obviously, we needed to test our approach. but now I would say the day and age of just needing people to solve captures to get a good model are over what you need to know now is you need to get basically you need to train AI models to understand how human beings are solving problems in the real world so you're not just extracting an annotation like this is a bicycle this is a crosswalk, this is a horse you're also codifying the way someone is solving a problem, you know, in their day-to-day operations. So it goes a bit further.
1:00:59So you want reasoning, you want models to kind of say, okay, so when that happens, well, Bob did this, so it's the right way to solve it. And then I can kind of remind that. So you mentioned distillation earlier. And then also, I think you said chunking a model. So it sounds like what you're doing is taking a general VLM and then letting your miners essentially cut it down and heavily tune it. So that way it does one thing. Well, I think you mentioned people detection, but the models that the miners create are problem specific. So if I made a model as a miner for subnet 44 to help identify, let's just say chickens crossing the road to keep it nice and generic and neutral, then would I win all the emissions from that?
1:01:45If my model stayed the best for that specific task. So for each task, each skills, we've got a winner-tech-sol mechanism. So we always want to have the best model and to pay all the rewards that we're allocating to a task to one individual model. So we can also run this model through our front-end, which I'll show you later on. Yeah, well, actually, that's where I wanted to get to next, because we're talking about the BitTensor backend here. But the front end of your company, which is called Manico, is a pretty, and I say this with love, standard looking software service. So the non-standard part of things is that our front end is actually collecting all the skills from the subnet, so from the infrastructure, and putting it together automatically.
1:02:34So it's a full agentic platform that knows exactly what you're trying to achieve just from a chat with you. So you just come with a prompt. And from the prompt, this platform is going to build a full computer vision pipeline from fine tuning your model. So this is the chat from fine tuning your model to creating your computer vision pipeline and also your deployment. And you don't have to know anything about computer vision. So as you can see, we can create we can generate the code for you. We can generate an SDK that you can plug into your your own app. And also, yeah, and maybe maybe you have a question.
1:03:09Sorry, I saw you're raising your hand. Yeah, I want to clarify something for folks out there who may be a little bit less familiar with this. But when you say fine tuning, that is taking the Alex Incorporated information and giving it to the BitTensor selected best model for my task. So that way it has the base intelligence for the task that I have. And it knows my company's context, right? Yeah, exactly. And in this case, for instance, I was mentioning car detection. I was mentioning, you know, person detection. this is something one of our partners created you know for using the alpha version of our platform they wanted to know across all their stations they're running they're running gas stations they wanted to know every time something like like a car or a truck would kind of crash into a pump and they and they and they started building their own custom model and and and within within a few minutes they realized that they actually found something that happened you know across one station one of their stations which is a truck completely smashing the roof of a pump um and i'm and i'm laughing but in reality when that happens um without things like manaco and agents plugged into subnet 44 um they would have to wait until someone would realize that something happened you know called someone at the station because most of the time in europe that those stations are completely you know automated and then the time to action would be in hours sometimes 24 hours with this system you can literally get a message on slack whatsapp whatever in a few seconds yeah lon this brings back our prior points about agents eventually playing a large role here but i can absolutely see like you could have an agent running these for you and then passing the information to you and kind of being the go-between from your agent like hey a truck just hit our roof yeah yeah yeah and i mean when so like all businesses they have kind of a like a you know a time frame to kind of file a complaint you know uh to their insurance uh company sure and if you miss that it's like a hundred thousand dollars every time a truck you know crushes into a roof so for them that's that's really cool to have access to that type of thing uh but in general just for to know uh and maybe you guys have other questions our subnet is built for other agents to also access to those skills and we built it in a way where we have a twin competition we have the public track so it's fully open source so any of your um you know open claw agents would be able to use what miners would produce in open source and then you have a private track that is going to be launched this week where you know manaco is going to be trained on the actual real customers we have so they can have access to their own skills.
1:05:56Does that mean that some of the winning vision models over on the BitTensor competition will actually be different by the time they reach production on the customer scale? Yeah, but depending on which track they are processed through. So if they're processed on the public track, they're going to be generalized approach to computer vision problems and they're going to be open source. So you would be able to grab them and make them, you know, tweak them the way you want. On the private track, they would be tweaked based on the prompts people would, you know, write on Manico. This actually brings up a question that I had, which is who's paying for the inference?
1:06:32Because on the use of BitTensor competitions and token emissions to help find the best vision models for a specific task, I'm totally with you. But when Manico serves them to a customer, you guys are handling the inference costs thereof. Yeah, so we kind of fixed that problem. We created an app that people can download on their computer, and the inference is then running on their CPU. I'm shocked that it's that efficient. What am I missing? If you had your open claw agent running in like a Mac mini, it could like run this on its own. It wouldn't need to. Wow, that's amazing. Yeah, and the reason for that is because this kind of, let's say, you know, decompose approach allows us to move from a model like SAM3, which is like 3.4 gigabytes, to a model for the gas station that is like 50 megabytes.
1:07:23Because it's an expert model. So you can run it on CPU. Versus a mixture of experts model. You're just grabbing the one slice of it. Wow, that's neat. This is what I'm glad I actually read the MOE papers. Yeah, that feels to me like a very futuristic fit. Like that's what we all need to do all the time. Like I rarely need Opus 4.6 for my problems. I need a very specialized model that my agent could use just to help me write tweets. Yeah, 100%. And I think we should build AI that is smart enough to just use the exact amount of resources you need. You need to use. You're right. Yeah. That makes so much more sense.
1:08:0150 megabytes is nothing. 50 megabytes is like I sneeze 50 megabytes. I mean, often I'll have a Chrome tab that uses a gigabyte. Yeah, it's like a casual game is more than that. That's wild. That was one of the biggest blockers in computer vision as well. Because you could come to a client like the fuel distribution company, but the minute you tell them that they have to buy a machine, like a specific machine that they would just install on site, and then they have to buy a H100 or something like that, the conversation is over. You can't talk to them. it yeah well that's one thing i like about a lot of these budgets or projects uh max that we're talking to is that they they take all this really complicated economics and tokenomics and then it's kind of abstracted uh behind the scenes it almost feels like like it like an api hook that takes away you know the difficulty of telephony in the case of twilio but in this case it's just like do you need a custom tuned vlm well cool yeah we'll do it you don't need to know that BitTensor is behind it.
1:08:58And so to me, that's just so powerful. I freaking love it. But it implies demand on both sides. Clearly, you've shown that you can help make better vision models for commercial use. But how do you go about finding the customers who want to tap into it? Traditional business problem, but still applies in this case. Yeah, I mean, and also traditional, I would say traditional, I mean, not so traditional, but we do believe that and we're building a community of enthusiasts, I would say at the moment. We think that we would get more clients by letting people vibe code with the product. So we believe in vision vibe coding.
1:09:34This is one of our kind of strongest opinion on how our go-to-market strategy should look like. The second thing is we do have, and one of my co-founders is an expert in business sales. We also have within our team, people that are already connected to a lot of large companies. And also I can't talk about this right now, but we also managed to sign a very big agreement with a large corporation that is going to help us fix our distribution when it comes to large enterprises. And is that a technology company that you're partnering with? Give me one little hint. Sprinkle some hints on me. Sort of.
1:10:12Oh, it's IBM. Okay, got it. No, no, it's not. No, it's not. I don't want to do like an announcement of an announcement, but basically they help a lot of businesses, implementing tech in their day-to-day operations. I know who it is. Lawn. Max is in Paris. The company is based out of London. European company. Who is it going to be? It's going to be SAP. But I bet you... No comment. I'm not going to say anything. Stop putting our guests on the spot. It's fun. We're into the show. Being a little loose is good time. We're getting loose because the show is wrapping up. That's what's happening. So as you bring on more partners, is this kind of the year of commercial growth for Manico and Score and the subnet?
1:10:56Yeah, definitely. This is how we see our kind of 2026 year plan rollout. We need to go to market quickly. We need the app to be used by a lot of people. And also we need to show that it's actually bringing more value to the whole ecosystem. So yeah, 2026 is definitely our kind of commercial year for us. Well, between small models, great technology and economics that I understand, I freaking love it. If you want to learn more about what Max and his team are working on, go to manako.ai, M-A-N-A-K-O.ai. Or you can go through the various BitTensor world and look up subnet 44. Max, I think you've taught me more than anyone that I've interviewed in the last two months.
1:11:36So thank you very, very much. I learned a lot. And we'll have you back on when you announce that major partner. Amazing. And it's SAP. Thanks for having me, guys. Thanks, Max. Thanks, man. Cheers. Lon, this has been a real treat. I really hope people like the BitTensor Focus. It's a cool new ecosystem. It's an interesting project. Jason's made a couple of bets, and we're doing our standard learning as we go. I'll tell you who does love it, the BitTensor community. They have been very supportive throughout our exploration of Tau so far. And, you know, we love lots of enthusiasm, lots of passion from the Tau.
1:12:08It's gotten to the point now when I'm thinking about asking the spouse if I can take some chunk of cash, buy some tau and stake it as a learning experiment very similar to how back in like i i said it on this 2012 i'm i'm i'm putting i'm putting one stack into tau i think i think i'm i'm dipping my dipping my toe in i'm wetting my beak a little bit here a stack of hundreds a stack of tens or a stack of ones a stack is 10k a stack is 10k alex that's that's that's how that's how we talk on the street that's that's our that's our well i'm from the mean streets of rural oregon where we have stacks.
1:12:41Anyways, Lon, an absolute treat as always. Guys, Twist is back on Friday. My name is Alex at Alex on Twitter. He's Lon Harris at Lons on Twitter. We think you're fantastic. Thanks for hanging out and we'll see you next time. Bye-bye.
From the publisher
This Week In Startups is made possible by:
Luma AI - https://lumalabs.ai/twist
Lemon.io - https://Lemon.io/twistPlaud - https://Plaud.ai/twist
Today’s show:
What do drug discovery, the creator economy, and AI vision models have in common? In the case of Metanova, Bitcast, and Score, the answer is Bittensor. Yes, each of the three companies leverages the Bittensor network to get more work done, more quickly, in a completely decentralized fashion.
Metanova uses its subnet to run developer competitions to find exciting molecular candidates, parsing through a mountain of possibilities to pluck out the most promising for further investigation.
Bitcast uses its subnet to collect visibility demand from brands, which is served by video creators. The company is focused on the crypto niche to start, but will expand in time to other technology topics.
Score uses its subnet to generate highly performant, specialized vision models, which it then sells to customers through a platform (Manako).
In each case, the Bittensor’s economic engine unlocks global creativity to tackle tasks that were previously time-consuming, fragmented, or expensive to complete. Let’s see how quickly each company can scale and whether startups building on Bittensor can grow faster than their non-decentralized peers.
Timestamps:
0:00 Intro
2:19 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!
3:40 What is Bittensor?
7:22 Metanova Labs joins the show
9:28 Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist
17:16 How Metanova tackles the multi-billion dollar cost of drug discovery
20:48 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io
30:20 Bitcast joins the show
31:23 Luma AI - Luma builds accessible, professional-grade AI tools for creatives. Try Luma Agents for free at https://lumalabs.ai/twist
32:30 Mining crypto with YouTube
36:48 Why Bitcast is focused on the crypto space to start
39:11 How healthy is the creator economy?
47:26 When will the AI bubble collapse?
53:44 Score joins the show
54:42 How Score will make vision AI more accessible
57:16 VLMs v. LLMs
1:01:14 Demo of the Manako platform
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