How Pfizer made the highest scoring Pharma ad of all time - Susan Rienow

10 Feb 2025 · 52 min

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In short

Podcast Notes: Uncensored CMO - Episode: How Pfizer Made the Highest Scoring Pharma Ad of All Time with Susan Rienow

Episode Overview In this episode, John Evans interviews Susan Rienow, the Chief Marketing Officer (CMO) of Pfizer, discussing the success behind Pfizer’s Super Bowl ad "Knock Out," which scored 4.4 stars in System1 testing, making it the highest-rated pharmaceutical ad ever. The discussion covers various topics, including marketing strategies, audience engagement, testing methodologies, and insights into the pharmaceutical industry.

Key Themes

  1. Pfizer's Commitment and Mission
  2. Pfizer aims to "create breakthroughs that change patients' lives," focusing on oncology and cancer treatments.
  3. The pandemic experience showcased Pfizer’s ability to innovate and respond rapidly.
  1. Audience Complexity
  2. Pfizer caters to both healthcare professionals (HCPs) and patients, requiring a balance of technical and emotional messaging.
  3. The ad reflects deep emotional resonance while conveying scientific information.
  1. Advertising Challenges in Pharma
  2. Strict regulations require fair balance in advertising, which means disclosing potential side effects.
  3. The pharmaceutical industry struggles with low average ad ratings, underscoring the need for effective communication.
  1. Role of Testing in Advertising
  2. Testing plays a critical role in developing effective advertising, allowing for data-driven adjustments throughout the creative process.
  3. Susan emphasizes the importance of insights in decision-making and how these can enhance emotional resonance in messaging.
  1. Super Bowl Advertising Strategy
  2. The Super Bowl offers unique reach, as it attracts millions of viewers, providing a platform for impactful messaging.
  3. The decision to invest in the Super Bowl was framed around the need to drive awareness and engagement regarding cancer treatment.

Episode Breakdown

  • 00:00 - Intro
  • 01:20 - Susan’s Career Path
  • 20 years in analytics leading to her role as CMO at Pfizer.
  • Experience in various roles across different regions and markets.
  • 03:19 - Pfizer's Mission
  • Commitment to creating breakthroughs in healthcare, particularly in oncology.
  • 04:21 - COVID Vaccine Rollout
  • Discussion on the unprecedented speed and transparency of the vaccine development process.
  • 06:29 - Insights in Business Decisions
  • The importance of understanding market dynamics and audience needs to make informed decisions.
  • 07:36 - Addressing Different Audiences
  • Balancing technical information for HCPs with emotional narratives for patients.
  • 10:12 - Fair Balance in Advertising
  • The need for transparency about benefits and risks in pharma ads, reinforcing the trust relationship with the public.
  • 14:51 - The Role of Advertising for Pfizer
  • Advertising as a means to communicate critical health messages and the brand's commitment to innovation.
  • 17:04 - Decision to Advertise at the Super Bowl
  • Strategic reasoning behind entering the Super Bowl advertising space.
  • 20:12 - Future Super Bowl Advertisements
  • Insights into plans for upcoming ads and sustained engagement strategies.
  • 25:20 - Importance of Testing
  • Continuous testing to refine ad effectiveness and emotional appeal.
  • 33:31 - Building Confidence through Testing
  • Confidence in board decisions supported by research findings.
  • 37:39 - Impact of Minor Changes
  • Insights into how small adjustments can significantly influence audience perception.
  • 39:15 - Evaluating Super Bowl Ad Impact
  • Metrics beyond reach, such as emotional connection and campaign integration.
  • 41:22 - Qualities of a Great CMO
  • Importance of listening, data-driven decision-making, and patient-centric focus.
  • 46:40 - Advice for Young Marketers
  • Encouragement to pursue interests, embrace failures as learning opportunities, and be proactive in career development.

Key Takeaways

  • Successful advertising in the pharmaceutical industry requires balancing technical information with emotional storytelling.
  • Testing and consumer insights are essential for creating effective marketing strategies, allowing brands like Pfizer to connect better with their audiences.
  • The Super Bowl serves as a powerful platform for brands to communicate important health messages to a wide audience.
  • A great CMO must be a good listener, data-savvy, and focused on the patient experience.

Closing Remarks The episode highlights the intersection of creativity and data in effective marketing. Susan Rienow's insights emphasize the critical role of empathy, strategic thinking, and innovation in the pharmaceutical landscape, demonstrating how Pfizer has navigated these challenges to produce impactful advertising.

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For further details, consider listening to the full episode [here](https://www.youtube.com/watch?v=wNLhMZuA00c).

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Transcript

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0:06Ladies and gentlemen, welcome to the Uncensored CMO. Now, we are talking about Super Bowl advertising in this episode. I love the Super Bowl. It's the highlight of my year where advertisers raise their game and deliver absolute knockout performances on the big game night. Now, one of the brands that has done a stellar performance this year is Pfizer. This is the second year running that they've done a Super Bowl ad, and they have literally knocked it out of the park, scoring one of the top scores in this year's Super Bowl. So I'm delighted in this episode to be joined by Susan Reno, the Chief Marketing Officer at Pfizer, to tell us what does it take to make a winning Super Bowl ad and what goes into it, working with the agency, working with us at System One, and how do you make a Super Bowl ad that is not only going to be a success on game night, but is actually going to change lives as Pfizer deliver their mission to bring cancer treatments by 2030.

0:56This is a lovely conversation. She's got so much great advice to share, and I'm delighted to share it with you. Here it is. Susan, welcome to the show. It's amazing, John. Thank you for having me. Well, this is exciting. So we've just seen the Super Bowl. And I wanted to catch up with you because of course, you've put a lot of work into going on to the Super Bowl. And I can't wait to talk a little bit more about how you've approached it and what the results have been all that kind of thing. But maybe before we get there, tell us a bit about yourself. How do you get into marketing? And how did you get to where you are today?

1:25All right. So I started my career about 20 years ago, actually in analytics, which I think is germane to this discussion. So I was in consulting first, And then one of my clients was Pfizer, actually. So Pfizer at the time was hiring, and I came over to Pfizer to be part of the analytics organization. So I started out in the U.S. part of the business, first in analytics, and then I got my MBA and went over to U.S. marketing. And then in 2009, I actually left the States and moved to Europe, so moved to Brussels. And for sort of the next phase of my career, I was accountable for regional marketing.

2:00So lots of different therapy areas, emerging markets, developed Asia, developed Europe as well. And then I took the kind of third phase of my career, which was to move to the UK and took on general manager roles. So I was in charge of the hospital division for Pfizer in the UK. I moved over to the vaccines division for Pfizer in the UK and then ultimately became country president for Pfizer in the UK. So I've sort of had a circuitous route, but I'm now, as of last August, I've come back home to New York to be Pfizer's chief marketing officer. And in this role, my job is to try to modernize Pfizer's marketing.

2:41And it sort of links back to the original sort of phase of my career in that a lot of that actually is about how do you use advanced analytics? How do we incorporate complex data sets? How do we make sure that we're making data based decisions? So actually, I've always found that that sort of solid foundation on the data analytics side has always served me really well. I can well imagine that, actually. And most of us got a crash course in into Pfizer during the pandemic, didn't we? We're like desperately hoping the vaccine was going to come and, you know, delighted with the rollout and that sort of thing.

3:16Now, obviously, that's a little bit that most people be familiar with. But can you describe a bit about what Pfizer does, what your mission is for those people that might not be as familiar? Pfizer's mission is to create breakthroughs that change patients' lives. It's only five words. And the idea is that it isn't something that sort of lives on a wall or on a PowerPoint presentation, that it's actually something that drives all of the decisions that we make. So if you think about, for example, the pandemic experience, that ethos of really focusing in on proper breakthroughs, things that really make a difference, is where Pfizer is focused.

3:50So I think we're probably publicly most familiar at the moment anyway in terms of our vaccines portfolio. But actually the area of the business that is becoming increasingly more important and will form sort of the future of Pfizer is actually in oncology. So we have a world leading oncology portfolio today. We have a number of standards of care in the oncology business. And then we're also reaching for eight new oncology breakthroughs before 2030. So very exciting times for the company. Now, of course, during the COVID period, you know, vaccines were rolled at incredible pace. It was, you know, every sort of resource was put in it.

4:30I imagine that it's not usually quite as quick as that, is it, in terms of how you develop new drugs? No. I mean, the vaccines rollout during the pandemic was, it wasn't just unique, it was unprecedented. You know, the speed with which that was done, because the world needed them, you know. So there were lots of things that were done in parallel in terms of product development. So it's really important, I think, that we didn't cut corners, that we made sure that we were really transparent about what we were doing and how we were collecting data. And collecting data in exactly the same way with the same level of rigor.

5:00But we ran clinical trials, for example, in parallel. We did lots of innovative things to try to speed up the process. So, yes, I think the development of the vaccines during the pandemic was absolutely the fastest of all time. Yeah. Now, obviously, the legacy is significant in terms of vaccine for COVID. But has that kind of also changed how the industry goes about future developments? Has it enabled you to become more agile, for example, and quicker at getting regulations through? Yes. I think also there's an important development has been the advent of artificial intelligence. as well. You know, so we are starting to integrate AI really deeply into our sort of early stage pipeline development to help us identify, you know, which molecules are most likely to be the most promising, all the way through to commercialization and sort of my universe around marketing and educating the public, educating healthcare professionals here in the US as well.

5:55So AI has been a big transformer, I think, as well of sort of how we think about innovation and speed. Now, you mentioned your career path starting out in insight and analytics as well. That's an unusual background, isn't it, for a CMO? I wonder what advantage does it give you in terms of being maybe a quote I absolutely love. Mark Ritson always says, the one job of, you know, the CMO is to represent the customer when where decisions get made. And I love that because we often forget in our busyness to go and execute the latest thing that actually we're serving the customer. We need to bring the insight into the heart of the business.

6:28But I'd love your perspective on the role of insights in in business decision making? I think it's hard to overstate the role of insights in business decision making, right? So I mean, when I look at what you know, whether you're talking about marketing, you're talking about general management, having the fundamental insights about what is the market look like? What do people care about? How does your solution fit in with the needs of whoever your target audience is? I mean, those are fundamental things that you need to make sure that you get right in order to be able to communicate effectively, develop products effectively, etc.

7:01So, you know, I think being able to develop daring and breakthrough creative, the foundation of that is being able to have the strongest possible understanding of your audience. So I see those two things as being actually incredibly linked. Yeah. Now, talking about audience, you're in a quite an unusual situation that you've got to be, well, I guess in normal parlance, a B2B and a B2C audience, haven't you? because you've got to talk to healthcare professionals that are incredibly experienced, you know, under pressure, delivering, you know, advanced surgeries, let's say. And at the same time, you've got to talk to patients or potential patients.

7:36So how do you deal with the kind of complexities of the different audiences and different users of what you make? Do you know, it's an interesting question because there are differences, of course, right? So healthcare professionals have a load more expertise and knowledge and they're interested in the science. But fundamentally, if you look at what a patient is trying to do, you know, what an average person is trying to do and what a healthcare professional is trying to do for them, they are fundamentally the same, right? So as a person who is ill, you want to get better or you want to prevent disease if you're not ill.

8:08The physician or the healthcare professional is there to be able to help support you to do that. So there are differences in terms of the level of depth that we go into and how we describe the science. But in terms of the ultimate outcome of what we're trying to achieve. Everyone fundamentally, I think, is trying to achieve the same thing. So if you think about, for example, the way that we communicate about science in the big game ad, you know, fundamentally, it's sort of a foundational message that we use in the ad talking about Pfizer's eight cancer breakthroughs that we're fighting for for 2030.

8:40That's a very scientific message. But it also is a message that has deep emotional resonance, because it gives people hope for the future of cancer care. And that's something that is a human interest. That's something that's quite emotional for humanity, for average people, as well as being of interest to physicians who deal with oncology and are treating cancer patients. So I think there's a way very much to be able to marry those two things up. I think sometimes you can get so wrapped up in the head message, the intellectual message, that you forget that healthcare professionals are also people.

9:15And fundamentally for a lot of them, the reason they got into becoming healthcare professionals is because they wanted to do something, you know, really meaningful and important for other people. So there is absolutely an emotional side of things, as well as an intellectual side of things, I think, for both audiences. Doesn't get much more emotional than saving lives as well, does it? You know, whenever, you know, one of your loved ones is in care or in hospital for something serious, you know, that's a very, very difficult time, isn't it? And very obviously, naturally, obviously a very emotional time.

9:43So you've got both a rational message, but you're also dealing, aren't you, with people that are in incredibly emotional state as well. And, you know, I think, I mean, that's the same whether you're talking about communicating to people outside of the company, but also the motivation for the people inside the company as well. I mean, obviously, our scientists are at the heart and the core of our business. But also, I think a lot of us come to work because we deeply care about the impact that we can have on patients. So it is both intellectual and also emotional as well for us. and you also work in a in a highly highly regulated environment as well and and i found this wild when we started working together 18 months ago and anyone not in the u.s by the way will find this crazy but there's a thing called fair balance isn't there that um you might need to explain it to people but you have to dedicate an amount of your commercial over to talking about the potential side effects um it's up to 50 isn't it you you have to spend of your commercial so it it's a rather challenge, isn't it, to sort of communicate the message while also telling people the things that could go wrong?

10:45OK, so I may have my reaction to that question may be a bit surprising, which is. OK, so first of all, to explain what Fair Balance is for people who aren't familiar with it. And yes, it's the case for USDTC advertising, but it's a fundamental principle across lots of countries in terms of how pharmaceutical companies communicate, communicate, which is basically you have to make sure that when you're talking about the benefits of a vaccine or a medicine, that you're also talking about the risks. And so it's very important that our communications are balanced and that they communicate both sides, because every medicine, every vaccine has both benefits and risks.

11:20And so it's very important for us to be transparent about that. Now, how that plays out in the U.S. is that in television ads, in advertising to consumers specifically, that means you have to dedicate part of your communication and your messaging to the side effect profile or other things that consumers need to know about the risks of a medicine or a vaccine in addition to talking about the benefits of it. Now, my view on that actually is if you look fundamentally at what we're doing, what we create, we create medicines and vaccines that go in people's bodies that they trust to be able to help them either get better from an illness or to prevent them from being ill.

12:00This is a deeply trusting relationship and situation for patients, for healthcare professionals in interacting with us. So being able to have the trust of the general public, being able to have the trust of healthcare professionals is absolutely mission critical in terms of our ability to bring breakthroughs out that hopefully will change patients' lives. So I actually don't have a challenge with the idea that we need to be fair and balanced, I feel like that's what enables the trust then that allows us to communicate. So, you know, to me, it's not in conflict with the idea of our ability to communicate in an effective way.

12:40It's actually sort of a foundational thing that creates the trust that allows us to be able to operate. That having been said, when you look at the average star score of the pharmaceutical industry as an example, I think it's 1.3. It is. It is. In fact, it's out of the 45, 50 categories in the world that we try and we measure everything category. It's the lowest average star rating. Yeah. So we are, we don't do a very good job of being able to communicate in an effective way. And you can see that with the star score. And for me, one of the things that's been really interesting is, you know, I left the US, I was out of the U.S.

13:17for about 15 years, almost two decades, actually. And when I came back, the ads that are on TV today are actually remarkably similar to the ads that I was putting on air nearly two decades ago. They haven't changed in 20 years. And so for me, it's not the requirement that we're being transparent about benefits and risks that creates that problem. It's that as a sector, as an industry, that we're not doing a good enough job of communicating in an effective way of making sure that our messaging emotionally resonates, that we come across authentically and that we're really thinking strategically about how are we communicating?

13:58What are we sharing? How are we positioning what we're sharing? You do have to be more rigorous and systematic, I think, about your communications within the construct of the regulations that we have. But I think absolutely there is a way to do that. And if you look at, for example, what we've seen over the last sort of year or so, the systematic review that we've been doing at Pfizer with our consumer advertising here in the U.S., looking at the emotional resonance, looking at the messaging, looking at the branding, looking at the music, all of those sorts of things, have actually raised our star scores on average by about 40 percent.

14:34So it's entirely possible to be able to communicate in an effective way within the construct of the regulations, which I believe are completely appropriate, given the seriousness of the nature of what we produce. But you do have to be more systematic and creative, I think, to be able to make that happen. Yeah. And you've done an incredible job changing that star score in the last year. You've also as well, not just done that, but you've also gone onto the Super Bowl, haven't you, with brand new creative for Pfizer overall, I guess in terms of having a corporate voice. What was the thinking behind that?

15:08Because that's a big move, isn't it? It is. It's really exciting, I think. So I guess if you start with the sector sort of view on this, the sector average pharma score, if I'm correct, is a 2.2. That'd be right. Yeah. So also not very good in terms of corporate advertising. I think if you look at it from a Pfizer perspective, we are in a really unique position. You talked about the work that we've done over the pandemic. So our awareness in the general population in the U.S. is really high. So I think we have about 85 percent awareness of Pfizer, whereas the average is something like just over 50 percent.

15:42So, and if you ask actually sort of what are the associations that consumers have with Pfizer, you'll hear things like trust, like innovation, like science, breakthrough. I mean, things that are incredible associations and are things that we uniquely have if you look across the industry. So I think that puts us in a position of both tremendous privilege and also tremendous responsibility to be able to use that voice and that credibility and the associations that we've built up in the general public to be able to play a role in being able to get out the messages that we think are important in the most responsible way that we can.

16:19So a lot of our focus on the work that we've done associated with the big game, but also a lot of our work that we've done more broadly looking at the Pfizer brand and how do we communicate about the Pfizer brand has been a major corporate push for us overall as a company. Because the goal is that we can use our position in the market to really be able to inspire people to take action, to be able to advance their health. So, yes, it has been a real transformation about how you think about corporate advertising and being able to think about our role in society and the perceptions that exist with us and how do we use that for good.

16:56And so far over the course of the last 18 months, two years, we found it to be tremendously effective and something that we're really quite proud of. Incredible. And in terms of deciding to go all in on the Super Bowl as well, it's notoriously expensive. And there's always a debate, isn't there, about justifying the eight or whatever million dollars per 30 seconds that goes into it. How did you approach that decision? Did everyone sign up to that? Or was it a little bit of a debate about whether it was worth it or not? Well, do you know, I think the big game is a really unique opportunity, right?

17:31So I think it's something like 120 million Americans. watch the big game every year. So if you're thinking about a platform where you can reach the broadest possible audience with a message, it really is unique in all of the different channels and opportunities that companies have over the course of the year. And if you think about what I described earlier in terms of Pfizer's commitment to cancer, commitment to oncology, you know, I think it's something like 40 % of Americans, sadly, can expect to have a cancer diagnosis at some point in their lives. So, you know, this is an area that affects millions and millions of Americans.

18:07So if you want to communicate effectively, get people to take action early in their journey, make sure they're diagnosing early, that they're treating early, all of those sorts of things that they're doing early screening, you know, you want to be able to reach as broad an audience as you can. So the big game is really unparalleled in terms of being able to do that. But 2024 was our big game debut and we scored 3.8. I think we were 11th out of all of the game ads, if I remember correctly. And this year, what we were seeking to do is try to actually build on that and make it even better, more effective.

18:42And so we were really pleased to have ended up with a 4.4 star rating, which I believe puts the ad as the number one most effective ad in your entire pharmaceutical database, right? Exactly right. It is the number one pharma ad. And we've tested thousands, thousands of pharma ads. So, yeah, it's an incredible achievement. Yeah, so this has been something that I have been personally screaming from the rooftops for about three weeks from now. So it's something that we're tremendously proud of. And then I think the other thing that we tried to do with the big game this year that we didn't have in place last year was to try to drive the traffic.

19:19It's not just a reputational message, but also to encourage people to go ahead and get screened early. You know, we know that the treatment outcomes are much, much better if you screen early, if you find cancer early. So we're really proud. We've partnered with the American Cancer Society this year to place their Cancer 360 assessment onto Pfizer4All.com, which is sort of our one-stop consumer hub that sort of helps people navigate the health care system. And so our hope is that not only are we sort of inspiring people about the future of cancer care tomorrow, but we're also being able to actually provide practical help today as well.

19:55So it's absolutely building on the success that we had last year, hopefully with more arms and also with more effective communication as well. It's an amazing spot. It's one of those spots that really does put chills down your spine when you watch it. I'm sure a lot of people will have seen it but for anyone who hasn't seen it just just talk a little bit about the the spot itself the ad opens on a little boy in a hospital bed and he is watching the tv and on tv is the opening of a boxing match so you see him in the bed and you see him watching the sort of opening of this boxing match and he's looking at his hands and you hear the the announcer say, the kind of classic, you know, let's get ready to rumble like that.

20:44And then the ad shifts from reality into this sort of epic journey of this boy home from the hospital on his way back to his parents. And so the first moment where you realize that we're on this sort of epic journey is his feet come out of the bed. And instead of just a child's feet, he's wearing boxing boots, black boxing boots with gold laces all the way up. And then you see him, you know, in a lot of hospitals when cancer patients go into remission, there's a bell and they ring the bell as part of sort of the celebration of leaving the hospital and being in remission. And so he rings the bell.

21:24But when you see him ringing the bell, he's wearing actually boxing gear. So he's wearing boxing shorts. He's got boxing gloves. And so he rings the bell as a kind of kickoff to this moment. And then all of a sudden you hear the sort of powerful anthem. You hear LL Cool J's Mama Said Knock You Out, Come In, as this kid starts his journey out of the hospital. So he starts to walk down the hospital corridor. And all the people in the hospital start to crowd around him, cheering him on, celebrating him. Some of them are crying in joy about how he's been able to emerge victorious from what has been a really difficult situation.

22:04He goes through the hospital corridor and out into the street where he encounters even more people. And the crowd builds and builds, all of these people cheering him as he's walking down, you know, doing the classic sort of, you know, boxer victory moves. You have confetti starts to rain on the whole scene. And then he goes up a whole series of steps and gets to the top of the steps and does the classic rocky maneuver with the hands in the air. And at that point, a super comes on and it says, hey, Cancer, we're going to knock you out. And for me, that's like the moment where the optimism of that, the determination of that, the resilience of that, you know, that this boy has won.

22:46He's beaten it, you know, is the most for me, the most amazing sort of high point of the ad. And then it shifts again. The music shifts a bit. And you start to see the boy sort of transition back to real life. So from the sort of fantasy celebration of his victory into his actual life, he's running down the street. He runs home and the door opens. His mom's there. And he goes and gives his mom a hug. And as they're hugging, it flashes back into a series of still photographs of, you know, what his journey has been like. So it shows sort of him being in the hospital and sort of the journey of being a cancer patient, going through treatment out through the other side.

23:25And I think for me, that moment, what it does is up until that point in the ad, it's a very celebratory, hopeful. It's got swagger, you know, that this kid has has has emerged victorious and has beaten his disease. And then all of a sudden you are reminded of the seriousness of what he's just been through. You know, so it takes you back to understanding his journey and what his family has now gone through, which makes the fact that he's now emerged victorious, I think, even more poignant, even more emotional and more serious. And then at that point, a super comes up and it describes sort of Pfizer's role in this fight.

24:05So it says Pfizer is fighting for eight cancer breakthroughs by 2030. Visit Pfizer for all to join the fight. And so the ad is both a celebration of the determination and the resilience of patients. It is supposed to be able to create hope about the future of cancer care by talking about some of the science that's emerging. And then also with the reference to Pfizer for All at the end, hopefully it also gives people some resources to be able to do early cancer screening and detection and also find some other tools for other disease areas as well. So, yes, we're very proud of the ad. I'm very proud of the ad.

24:39It's been amazing how it's been received. You should be very proud. It's the best pharma tested ad on our database. And it outperforms the norm by an astonishing margin. I mean, that's the other thing is how much better it is. Because particularly as you're in a serious category, aren't you? And therefore, you know, to deliver something that emotional, you know, in a serious category, it's not like we're talking about confectionery or pet care. Something where, you know, just having, you know, pets or confectionery or beer in your ad would give you a high star. But, yeah, the reference point in this is a difficult one.

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25:16So, yeah, well done. It's absolutely brilliant. You talked about your journey from analytics and insight. What role does the kind of testing play in the process of getting to something quite as emotional as that? Yeah, so, I mean, I guess the starting point is that Pfizer uses System 1, as you know, for all of our ads now. So I think we've tested 300 ads over the last couple of years. So, you know, we think that having the sort of standardized approach with really clear benchmarks linked to ROI that allows us to be able to understand how our various ads are performing against themselves, but also how they're performing against other benchmarks has been extremely useful for us to be able to improve the sort of emotional resonance of the advertising that we've put out there.

25:59So our sort of partnership on the big game ad is not unique. We do it with all ads. That having been said, the other big statistic that I'm really proud of is I believe, and you can correct me if I'm wrong, but not only is it the highest scoring pharmaceutical ad that you have in your database, but it's also in the top 2 % of all ads that you have in your database, regardless of industry, right? That's quite correct. Yes. And so I think this has been absolutely a group effort to be able to get here. So if you describe sort of the journey that we've been on, we have a partnership with Publicis.

26:31They're our agency. when we started working on, you know, what we wanted to do for this year's big game. Of course, we start with, you know, really great brief and really good insights and all those sorts of things. And then Publicis brought us maybe six or seven different options, all of which, you know, were coming at it from different angles, different emotions, different calls to action, et cetera. And at that point, we were looking at multiple different versions. So do we talk about multiple therapy areas? Do we just talk about one? You know, Pfizer has lots of medicines and vaccines in different categories.

27:00And so was there a specific place that we should focus, et cetera? So you put all of those into system one to start to get a sense of where we should narrow down. And we started to land on the kind of concept that ultimately became the big game ad at that point. Then we put it back into testing to realize that we needed to not focus on multiple therapy areas, but really we needed to focus in on oncology. That was the one that had the greatest resonance and the greatest fit also with sort of Pfizer's mission and our promise and our commitment for the future. Then the next big pivot point was we actually had two different endings to the ad as well.

27:37And they both scored reasonably similarly. And I remember trying to figure out – I think we sat down with you, John, personally, which is amazing – to get some advice about what should we do, you know, which direction should we take. And I remember you looking at sort of the trace scores and being able to say, you know, look, this one, it scores really well, this ending. But I think you're about at the peak that you're going to be able to get to in terms of emotional resonance. Whereas this other one, if you can sort of overcome a blip that we were seeing at a certain point in the ad, then I think you can actually get to an even higher emotional resonance.

28:13So we aren't – in our work around testing, it's not – we don't test something at the end and then sort of hope that it works. We're testing it all the way through. We're looking at it sort of second by second, making decisions about how swapping things out, switching things around will make a difference in terms of the story arc and then also the emotional reaction as well. So the ad itself is the result of many, many rounds of testing and many, many rounds of feedback and advice, I think, both from the agency side, from our side, and then also from your side as well. You mentioned Publicis, actually, and massive credit to them as well, firstly for the creative ideas, which are brilliant.

28:51And actually, there were a lot of great contenders in the early rounds as well that all did quite well in early stage testing. But, I mean, this one was standout. And my favorite one as well from early on. So I'm really happy that it came through. Well, you always kind of look as a professional, you know, as someone who's there to help testing. But of course, you have your own point of view as well, don't you, as you go through it. But I think it's a really good example of where the creative agency, you guys as obviously the client and we as the sort of the tester in this process kind of collaborate as well.

29:24Because as you described it as well, I think you're absolutely best in class in terms of deciding the role of the music in terms of the peak ends. the role of editing. So which scenes do you use and which order do you use them in? So even down to decisions like that, you know, and the speed at which you're able to turn things around. I mean, I don't think I've ever been testing at the rate of knots that we test with you, honestly. So we filled up a few weekends over the last few weekends going, right, can we get this tested on Sunday? So results are back first thing on Monday. And, you know, even within the day, I think we were kind of turning around testing as well, which is amazing.

29:58Yeah, it's great. And obviously a lot riding on this. Do you know, though, I mean, I have an amazing team that really wants things to be perfect. So we really were looking at it second by second by second, trying to understand what was happening and how we needed to adjust it. I think also I need to give credit to the senior leaders at Pfizer as well, because one of the things that can derail ads is if you let your personal opinion come before what the testing results are. And an individual's reaction to a piece of creative is very individual. So one of my own views is that you always have to be guided by what the research says.

30:31And one of the things that I was really pleased about, you know, this is my first big game ads as my first sort of exposure to how senior leadership was thinking about it is they were absolutely laser focused on what the research was telling us and going in the direction that the research was telling us about how the ad would be received. So we very much were aligned in terms of having one source of truth about how we needed to move forward with the development and then ultimately the rollout, which I don't take for granted. It's quite a privilege and a positive thing to have. you're quite right actually i mean your team are so exceptional at that i mean obviously we work with lots and lots of people and not only do they really believe in the role that the testing plays and the standard you're trying to adhere to but the passion that they have for the work is just amazing as well and and what makes me happy as well because you know as you know something i do every day is just to see the delight from the team when they see the score go up and the celebration It's lovely.

31:30It's just and it makes it, you know, it's great to see, but it makes it extra worthwhile when you see a team respond with such enthusiasm and in the publicist as well. It's just brilliant. A real team effort. You can see how much people care about the quality of the result and what it all means as well for you as a business, which is exciting. And one of the things also that for me has been really exciting is as as the ad developed and we started getting more and more partners involved. Right. So we have a partnership with LL Cool J, for example. You know, his wife sadly was diagnosed with cancer.

31:58And so he and his wife are also working with us to raise awareness around early screening and detection. But of course, it's his music in the ad. And so there was this amazing moment in the development where he was listening to he was watching the ad listening to the music and he's saying, you know, this is amazing that my song is being used for this great purpose. And he's like, but, and he called up one of the creatives and he's like, I think in the transition between this scene and this scene, if you add a beat of the song here and cut a little bit away here, I think the musical arc will be more powerful.

32:29So like, hello, Cool J leaned in to help us optimize the ad. You know, the American Cancer Society has been tremendous. They've been absolutely incredible in terms of, you know, they saw the ad very early on. They were really supportive. The partnership with them has been really powerful and really important from our side and hopefully important in terms of the credibility of the effort as well. So there has been a lot of mothers and fathers to this particular ad. And I think all of us are proud of it and hope that it does some good in the world. Yeah, well said. I mean, you know, the music thing is such an important role.

33:02And as you say, the way it slows down after you've got the rocky moment, that's critical to the feeling you have in the final section where it cuts back to reality. And you have that bump back to, yeah, this is real. This is real. And then you see the emotion of the hugs of the family at the end. And you think, wow, that's the, you know, the chill moment, isn't it? And the music is a key part of that. The way, as you say, the way he kind of changed, you know, the way the song's been changed in that second half is very profound. um i was going to ask you that because one of the things that i used to be a system one client actually because i most of my career was client side and um the one is funny when people used to say to me what what do i use the testing for my answer was often actually it's about confidence it's about confidence in you're taking the right direction but it's also about confidence in the broader business getting behind something whether it's kind of the board or senior management and is that how your experience has been in terms of its role yeah i mean i would say it's deeper Certainly confidence.

34:03Absolutely. Because like I said, it gives you a single source of truth that you can use with everyone. And because it's independent, because it's validated, because it's standardized, you know, there's no sort of second guessing around whether you're cherry picking certain data or, you know, trying to make yourself look good or whatever. Like the score is what the score is. And you have a database. We have been eagerly in the entire prep up to the big game, as you know, we have been looking at our rankings relative to other ad rankings and seeing where we are relative to other companies. It becomes sort of the North Star in terms of whether you think you're communicating effectively.

34:40So absolutely in terms of kind of getting alignment and confidence around it, yes. But for me, the part that has really been the fascinating part is the degree to which you can forensically look at exactly what's working within an ad and what isn't working. So another good example is the first time that we put sort of the finished ad through, one of the things that was lower was around brand fluency, right? So the degree to which people understood that this was an ad from Pfizer. And I remember your team saying, look, you need to give people a clue that this is a Pfizer ad earlier in the ad so that people can follow the storyline and understand what it is that you're trying to communicate.

35:20So there is a point when the boy is on his epic journey, when we cut to a Pfizer scientist who's looking out the window and kind of nods at the boy. That's actually a real Pfizer scientist. It's actually an actual oncologist who is working on developing new oncology therapies that we invited to be part of the ad. And that piece was created because we knew from system one that we needed to increase our brand fluency. And so being able to make it clear to people that this was an ad from Pfizer, but at the same time making sure that we weren't taking over the whole narrative, right? Because there's a very fine line on something like that.

36:01What you don't want is for that to be so prominent that it looks like we're taking credit for the success of the boy. Because the success of a patient, of a healthcare professional, of their family, there are obviously lots of people that are involved in that journey and that own that success. But we also want to make sure that people know that it's a Pfizer ad. So I think the testing, some of it was about confidence. But we were really making decisions second by second about what we were including or not including in order to be able to get to the right place. And I agree. I think my team deserves a lot of credit.

36:31The publicist team deserves a tremendous amount of credit. I mean, they were working nights and weekends. I think they must have gone crazy by the time we finally finished the ad of like the number of revisions that we've done, the number of calls to action that we had tested. I mean, all of that was – they were turning it around overnight again and again and again for us to get to a place that we really felt confident about. And I think there's a professional pride in that, but also I think there is a pride in the sense of – I think – this may sound cheesy, but I think we all genuinely believe in the message that we're trying to communicate.

37:03And so we want to do right by cancer patients, by the science, by what we're trying to do as a company. I mean, all of those things actually matter. So for us, making sure that we were able to communicate in the most effective way was sort of morally important as well as being sort of professionally important as well. You made a really good point about the fluency in the scene that you just talked about there. And that's something we try and encourage all clients to actually is to authentically place yourself in the story rather than just like, here's our logo or like, you know, here's our pack shot or whatever.

37:36Find ways to embed yourself in the story. And that was, you know, a perfect example. The other thing actually I noticed that was quite striking coming through the research when we're looking at different, even different edits is the associations people had with the Pfizer brand. It differed really with some quite fine tuning. So some very subtle different executions of the same idea. Actually, you could see how people took out a different message. You know, it is a broader message or it is a more specific message. But it's amazing. you know i think people don't realize how small changes in these kind of things can actually lead to quite big differences in how people perceive you as a brand completely you know one of the things that surprised me was if i if you were to ask me before testing what are the critical things in in order for people to understand that this is a pfizer ad for example right it would it would have been the amount of time that we had with the scientist and the degree to which you could see the the logo on the um on her lab coat and it's also of course at the very end when we're talking about the breakthroughs and we're talking about going to PfizerFall.com and we have the logo up at the end.

38:40But actually, there were versions of the ad that had those two things exactly the same, but the middle bit was slightly different. And depending on where people were emotionally in terms of how they were responding to the middle bit made them more or less pay attention to or notice the logo at the end. And so that to me was completely counterintuitive in terms of how people were absorbing information, very much depended on where they were in terms of their emotional state at the point at which the information was presented. And being able to actually see that real time at the level of detail that we were able to see it was incredibly helpful.

39:17Yeah, amazing. And how do you evaluate the impact of something like a big Super Bowl ad? Yeah. So, I mean, I think there's reach, obviously. But, you know, if you're looking at the big game, you get reach naturally out of that. Last year, if you look at the number of visits that we had to our site following the big game, I think we had about 2 million visitors over the course of 10 days, which way exceeded all of the traffic that we had to any of our other corporate sites or our branded sites or any of that sort of thing. So reach is one element. We're also looking at the quality of the creative, the ability to emotionally connect.

39:51So, of course, last year we had a 3.8. This year we have a 4.4. So we can tick the box there that we feel like we're communicating in a more effective way this year, which is great, building on what we did last year. We're also looking this year about how this can be integrated into a full-year campaign. So rather than being a one-off effort, which is what it was last year, this is the kickoff of a full-year campaign where there will be presence on all of our digital platforms. There'll be presence on social media, community outreach, and all of the other channels that we have. So there are specific metrics attached to each of those as well.

40:22So if you look at, like, Pfizer for All, for example, which is the website that we are inviting people to go take a look at, there are cancer screeners. There's the ACS, the American Cancer Society's Cancer 360 screener. There's also screeners for – or questionnaires for atrial fibrillation. There are this information about migraine. There are things about vaccines. So there's there are a variety of different things that consumers in the U.S., of course, because the U.S. audience can go to to be able to help navigate the health care system and get home delivery of Pfizer medicines or understand what their vaccine eligibility is or, you know, be able to identify whether they're at risk for certain kinds of cancers and be able to schedule an appointment.

41:05So our hope is also that we're making an impact in terms of being able to help support people today. So we'll be monitoring all of the metrics around that as well to make sure that the pull through into the patient support that we want to be able to kind of rally people around is actually happening as effectively as we expect it to as well. Super important, isn't it? Super, super important that that happens. I wanted to pivot a little bit if I can. You've done a lot in your career. You know, you've managed different markets. You know, you've come up through Insight. You've been general manager.

41:36Now you're the CMO of one of the kind of biggest brands in the world. What advice would you give? What have you learned on the journey about what makes a great CMO? I think the first thing would be you have to be a really good listener. So you have to be a really good listener in terms of understanding the needs of your customers. And as you've correctly mentioned, if you think about my sector, you have HCPs, you have patients, you also have government bodies, you have regulatory authorities. So understanding where each of our stakeholders are, what they're looking for, how we can fit into the solution, how we can support that is really important.

42:13In my sector as well, being really, really laser focused on the patient is absolutely critical. That is why we exist. If we weren't able to create breakthroughs that help people either to get better or prevent illness, then we would not exist. So you have to stay focused on the people who benefit, hopefully, from what you're creating and really understand deeply what their journey looks like and make sure that you're tailoring your messages to them. And I think the final thing I would say is the use of data is just irreplaceable. There is so much data, particularly in the U.S. now, to help you understand what's happening but then also to really refine and optimize what you're doing.

42:59So, you know, I think in the old school, when I started sort of my career in marketing, you were very focused on, you know, you did an ATU. You understood sort of – you did some basic message testing. You know, you did sort of some of that stuff and then you created a campaign and you tested the campaign at the very end to understand what the – you know, whether it was good or bad and hopefully it wasn't bad and then you could put it on air. You know, the sophistication now about how we can understand our customer base, how we can tweak, as we've just discussed over, you know, the period of this discussion, the way that you can tweak your messaging so that it resonates in the right way is extraordinary.

43:37And then when you start talking about deployment from a media standpoint, for example, you know, the AI algorithms that exist to help you find the audiences that are going to be the most receptive, that are the most interested in your message. I mean, all of that that exists today is absolutely incredible. So staying, you know, paying attention to the data, paying attention to AI, to predictive analytics, to what the data tells you and being willing to adjust and modify dynamically on the fly would be the other, I guess, the final point of advice. That's great. I mean, people assume that as a CMO, it's all kind of innovation, creativity, arts and that sort of thing, don't they?

44:14But actually, you know, you're in a business. You need to look at how you're shifting those business metrics and delivering results. And the data is so important, isn't it? And I mean, other people on the C-suite often have, if you're in sales or if you're in finance, you've got a lot of, you know, data is standard really in your world. But I think with one of the challenges that CMOs often face is actually bringing the data to the party. But it's so critical, isn't it? And then it's often the best way of winning over your colleagues and the organization if you can bring the data because it's hard to argue with that.

44:42Completely. You know, there's that old adage that if you ask people what they wanted, they would have told you a faster horse, right, instead of a car. I take issue with that because what you're – the premise of that sort of old adage is that you're asking people what the solution is. The creativity is in finding the solution. But asking people what their problem is is something that absolutely has to be grounded in an insights-based approach. Like if you don't understand the problem, like in that metaphor as an example, the problem is you can't get from point A to point B fast enough. That's the problem.

45:18And then the creativity kicks in around how do we solve that problem in a completely new and different way? How do we transform the solution to that problem? If you think about my industry, you start with nothing and then you innovate and create an entirely new science that then solves people's problems from nothing. I mean the innovation comes from how do you solve the problem. It does not mean that you shouldn't be looking at the data to try to understand what the problem itself is. So to me there's a really important distinction there is creativity and art and daring and all of those sorts of things are bread and butter critical to being a great CMO.

45:55But if you don't understand what the problem is, there's no creativity that you can put at that that actually solves it because you're pointing it in the wrong direction. Yeah, I love that. That's a really good definition. Because we often have this debate in marketing between sort of data led, performance led marketers and the sort of brand led marketers who are supposedly more creative. But your definition is spot on because actually creativity is in coming up with the ideas and the solution. but you've got to start with the data and end with the data, you know, in terms of like, what's the problem, you know, what solutions are going to work and then evaluate what they have done and make sure you're evidence-based.

46:31And I think that's a beautiful way of kind of solving that conundrum that marketers often get categorized into the data-led ones or the creative ones. And actually it's the combination of both, isn't it? And that's critical. Maybe to round up then. So looking back on your career is what would be the one bit of advice that you'd give a younger version yourself or to somebody starting out now? You know, you do this as part of your career planning at big companies, certainly at Pfizer. You are often asked sort of, what do you, you know, what are you aiming for? What do you expect to do in three years?

47:03What do you expect to do in five years? My own personal experience was that I never had any idea what I was going to be doing in three years or five years. You know, I was always trying to find things that were interesting and that I felt like would grow me professionally, but also be interesting from a life experience standpoint as well. And there was a certain point in my career where I just sort of gave up on that obligation of having to sort of define my own life. Because if you'd asked me at the beginning of my career, where did I want to end up, I would have said I wanted to be a market research team leader.

47:36That's where I would have wanted to be. I never thought that I was going to be moving around the world and living in all these different countries and leading up countries and then becoming the chief marketing officer for a fortune 50 company i mean those things were never on my radar so i my recommendation would be to relax a little bit go for the things that are um that are fun and interesting do a really good job be good to people be a good collaborator and don't you know don't focus so much on the end goal focus on the journey itself oh i love that advice that's so good that's so good i mean i've been reflecting on that a lot myself and um i mean maybe maybe it's age but i just think following the energy right work out what gives you energy you know what i mean because if you've got the energy for it you're going to do a much better job and then become really good at something so that people want you you know want you to in their team and so on and then you're absolutely right is that you know we used to have this idea that a career was like this ladder of this to that to that and so on but actually today's careers are much more i mean there's a book um called squiggly careers which i love as a concept you know and it It is that, isn't it?

48:39You have to you can only you can only take, you know, what opportunities that are there in front of you and you need to create those opportunities. But it's really hard to predict what those will be in five or 10 years time. So almost kind of building your network as well. I mean, man, your network is your wealth, isn't it, in terms of opportunity. So building that up as quickly as you can as well is going to help you. And I'd also say don't be intimidated by other people's careers. You know, I call it the Instagram version of someone's career. When you get up on stage in a panel or something like this and you go through sort of the litany of everyone's successes and you don't hear about the time when something went horribly wrong and the person failed and was crying in the bathroom and those sorts of things, that happens to everybody.

49:20So I think don't get too intimidated by these stories of extraordinary success and jumping from one amazing thing to the next amazing thing. Everybody has failures. Failures are really, really important. And so I think it's also really important not to compare yourself to others and, you know, to continue to have confidence in yourself and be able to try to make yourself the best that you possibly can be. And in fact, you probably learn a lot more in those failures as well. And those oddly, those failures are almost like springboards that you you can use them as energy and also use them as insight into what didn't work that can help you help you go on.

49:54And the other thing that she that I discovered as well that I kind of maybe wish I'd learned earlier is sometimes you can create the job you want. You know, we kind of think that we have to apply for the job we want. But the other option is you create the job you want, a bit like doing this podcast. But you can, you know, if you spot an opportunity in a company for something you don't think is there, put yourself out there and say, I want to go and fix this. I want to build this. I want to be the person that does it. And very often you can kind of create your own career. But we sit there waiting to be asked so often, don't we, or waiting for the HR manual to tell us the next step.

50:25But go create it. Go find it. Completely agree. Susan, it's been a real joy to speak to you. thank you so much for doing this it's a genuine pleasure to work with you work with your team and we thoroughly enjoyed being part of the Super Bowl journey and dead proud of what you've what you've achieved so massive congratulations to you and the team and thank you for being open to coming on and sharing your journey and all the wisdom as well thank you no my pleasure John thank you for having me on and thank you for all of the partnership along the way and being willing to turn things around in crazy time periods over weekends to help us along the journey.

51:02I hope that the end has justified the means. And I hope when we all look back on this, that we will all agree that we've done something really amazing. So thank you all the way. Totally certain of that. Thank you. Thank you very much for listening or watching Uncensored CMO. I hope you enjoyed that. If you did, please do hit the subscribe button wherever you get your podcast. If you're watching, hit subscribe there as well. I'd also love to get a review. Reviews make a big difference on other people discovering the show. So please do leave a review wherever you get your podcasts. If you want to contact me, you can do.

51:33I'm over on x at Uncensored CMO or on LinkedIn where I'm under my own name, John Evans. Thanks for listening and watching. I'll see you next time.

From the publisher

The Super Bowl is the biggest advertising event of the year, with the biggest brands in the world flexing their advertising muscles (and budgets). A new entrant to the Super Bowl in 2024 was Pfizer, and they're back again this year with an ad that has blown the socks off the Pharma category. Their big game ad "Knock Out", scored 4.4 stars in System1 testing, also making it one of the best ads overall. I speak with Pfizer CMO, Susan Rienow about what it takes to create such a successful ad in the most competitive environment.

Timestamps

00:00 - Intro
01:20 - Susan’s successful career so far
03:19 - What Pfizer does and their mission
04:21 - The Covid vaccine rollout
06:29 - The role of insights for making business decisions
07:36 - Dealing with the complexities of different audiences
10:12 - Managing the impact of fair balance in advertising
14:51 - The role of Pfizer’s advertising
17:04 - Why have Pfizer gone all in with a Super Bowl ad
20:12 - The Pfizer Super Bowl ad in 2025
25:20 - What role does testing play for creating an effective ad
33:31 - The role of testing giving confidence to the board
37:39 - How tiny changes can make such a big difference
39:15 - How to evaluate the impact of a Super Bowl ad
41:22 - What makes a great CMO
46:40 - Advice Susan would give to young marketers

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