806. GLP-1 Explained: The Gut’s Secret to Controlling Sugar Cravings

26:51I'm craving more sweets. I'm craving more snacks. It's something that's like, it's something I have to keep up with through the day if I have that. So in the morning time is like the most important time for me to watch my blood glucose levels. Yeah. Yeah. That makes sense. So it's awesome to wear those because you really do learn for you at different periods, like what's working or not working. Yeah. And when we talk about, you know, blood glucose and we talk about, um, diabetes and blood sugar, one of the conversations that we're having that so many people are talking about now is the GLP ones.

27:27Um, I know I have people in my family that have taken it. I know there's many of my friends that have taken it. People are taking it for, to lose weight. People are taking it for vanity. People are taking it for diabetes. There's, it's kind of running the gamut. I think it's probably been the biggest drug that's come on the scene since maybe Viagra or something like that. But I'd love to hear a little bit more about them. I think people kind of know what it does, but don't really know. So can you tell us a little bit about GLP-1s? Yeah, so the GLP-1 drugs that are on the market, so the Ozempic, Wagovi, Semaglutide, all of that family of GLP-1 drugs are actually mimicking your body's natural GLP-1 hormone.

28:10So your body actually makes GLP-1 hormone, and the way things are supposed to work is you eat a meal. It's actually metabolized by these trillions of microbes that are in your gut, and there's one department in that kind of manufacturing microbiome that is responsible for stimulating GLP-1 secretion. So when you eat, your microbiome is actually the primary signal to increase GLP-1 hormone naturally in your body. So you have this department of strains that their job is when you eat to say, oh my gosh, we just ate, let's release GLP-1. And you get a release of GLP-1 into your blood. And there's two really important things that happen when you get GLP-1 up in your bloodstream.

28:51One, it signals to your whole insulin response to metabolize the sugars you just ate. Number two, it tells your brain, we just ate, we're full, we don't need to eat anymore. And so those two signals go up when you have just eaten a meal. So now you're metabolizing your sugars. Your brain is being told, we just ate. We're not hungry anymore. And then over time, your GLP-1 will go down in your bloodstream. And then you'll get hungry. You'll eat another meal. And your microbiome, that department, will stimulate GLP-1. And you'll be like, so GLP-1 is actually supposed to be like this, like your sugar throughout the day.

29:23And so what is happening with these drugs is they are trying to mimic that GLP-1 hormone. And so these are chemicals that you're injecting directly in your bloodstream. So they don't kind of metabolize in this up and down. You're kind of keeping them at really high levels all the time. And so what's happening is all the time you're getting the signal of metabolize the sugars we just ate, we're full. Metabolize the sugars we just ate, we're full. And that's why when people go on them, they have almost an immediate impact on their hunger. Some people even feel a little bit nauseous because the signaling is so strong.

29:55And so I think about these GLP. And so you don't go on the cycle. You kind of got this signal happening all the time at a very high level. So you get this immediate really great impact. But then when you go off of them, you get this immediate rebound because you haven't really taught your body to make its own GLP and hormone. You're just supplementing. And the thing about the drugs and kind of keeping it at a high level all the time is it's almost like talking through a megaphone. Like I was talking to you through a megaphone. You would definitely be able to hear me clearer. But after a while, you would go deaf.

30:25And that literally happens in your body where these beta cells that secrete insulin, they can become deaf to the signaling and they can stop working. And that's why with a lot of drugs, you have to keep titrating up doses because your body actually responds by going deaf. And so that's kind of the downside to the upside of getting that immediate response of those drugs. So if you kind of go over to this side and you say, well, what about your natural GLP-1 hormone? If you can stimulate that, you're really teaching your body how to fish. And so you're teaching your body to re-release the GLP-1 hormone when it's supposed to and have it, you know, on the right cycle.

31:01And what happens when you're doing that well is you don't have these food cravings for foods that your body really doesn't need. You don't have that food noise that a lot of us are walking around with, like, just thinking about what's my next meal and trying to resist and then breaking the resistance and then feeling bad about it. You know, you don't have any of that stuff. And you're metabolizing your sugars optimally. And so that's really kind of the two different modalities to get at your GLP-1. Yeah, it's fascinating too, because, you know, in learning this from you and then just recently that we naturally create GLP-1.

31:34So what's happening though in the body where are people just overriding their natural hunger cues? and then the, cause what's happened, if, if we have a great healthy GLP one signal, wouldn't all of us not be overweight or what's happening there? That's causing people to causing us to need to supplement, you know, through drugs. Well, I want to talk about the probiotic, but through drugs to have this signal continually going, are we having the signal naturally going and then we're ignoring it? What do you think's happening? No, I think we're not having the signal. And so essentially, this is when we talk about metabolism.

32:15It is the metabolism of sugars. It's the generation of your body's GLP-1 hormones. So what we now know is that department that's supposed to release the GLP-1, there are only two strains known to date that have ever been published that can directly stimulate GLP-1 production. They're acromantia mucinophila and clostridium butyricum. You don't have to memorize those names, but those are the two strains. And when you are depleted in them, you're not getting that proper signaling. And the depletion in acromantia has been associated with a wide variety of diseases, not just metabolism issues like obesity, but also GI issues, neurodegenerative issues, inflammatory issues, immune response issues.

33:01And so these strains, particularly acromantia, are really, really important for that GL GLP-1 signaling to happen. And many people are just simply depleted in these. And acromansia has never been found on any food. So it's not like you can go eat these foods that are high in acromansia. And so we're all kind of facing this issue of not making enough of our natural GLP-1 hormone. That's why we have these problems. Wow. So was this the GLP-1 hormone, was this something that in researcher we knew about in the health space? Or is this, because I feel like I've just started hearing about and I've been in the health and wellness space for a long time.

33:40Have we known that this GLP-1 is what supports us in reducing hunger and balancing our blood sugar? Well, for decades, scientists have actually known about GLP-1 and these GLP-1 drugs that are on the market now that have become really well known, many of them, and especially their earlier versions of them, have been around for like 30 years. And so they're new to all of us, but the whole science behind it isn't new. And some of the things that these drug companies that have done is to just make these more and more effective. So even though many of these scientists have known about GLP-1 and known its power and what it could do, being able to create a chemical mimic that can do it as powerfully as these drugs can has taken a few versions.

34:28And so now we're experiencing this heyday where it feels like it's something totally new, but it's actually been something we've known for a long time and people have just been optimizing it to get it to how impactful they are today. And so we've known about GLP-1 for a long time. And even us at Pendulum, we've been working on GLP-1 for a decade. But just how do you harness that? That's the secret.

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38:16So we could say just based on what you were talking about with the drugs and the example of the microphone, which I love that someone that's taking it when you're taking that much of a dose of the GLP one from an Ozempic or Wigobe semaglutide, you potentially have the risk of damaging the receptors that receive the message and no longer having your body respond in the same way. Yeah. And I think if you're on these drugs, you'll know if you're, you know, working with a healthcare practitioner that they're going to, the minute they prescribe it for you is the minute they're also going to say like, okay, now let's figure out how to get off of them.

38:55And maybe there's a micro dosing or we'll do an on off, but your practitioner is always going to be talking to you about that from the first step, because they know that being able to do the on-off or being able to titrate down to the minimum amount you need is going to be best. Right. What do you think is... So would you say that's the biggest risk for someone that was taking it? What are the risks of taking that drug? Well, I think that there's a certain fraction of the population that is intolerant to the drug, And you'll know right away when you go on it if you're one of those people who's intolerant to it.

39:32And that's just sort of true of any drug. And you'll know you're intolerant if you're getting super sick or, you know, you're getting a reaction. I think in the long run, we don't know exactly what are going to be all the potential side effects because we're kind of running a mass experiment here. The drugs were developed and designed and studied for people with type 2 diabetes. There's a lot known about what happens in people with type 2 diabetes. But right now, the mass public experiment that's happening is, well, what if you don't have diabetes? And then there's even people who are completely, you know, they don't have obesity.

40:09They're not even, you know, clearly on this path towards diabetes. We're going to find out what are the different side effects for all these different individuals probably in the next 10 or 15 years. Yeah, in Los Angeles. I swear. I swear the amount and no shade, but the amount of people that I know on it that are absolutely nowhere close to diabetes, absolutely at weight or underweight. It's just, it's just fascinating. And, um, I've been interested in it because my dad has Alzheimer's and I know that, you know, Alzheimer's is diabetes of the brain. And so much of what I believe is a lot of his issues is related to his blood sugar levels and the diabetes that he's kind of experiencing in a different way.

40:57So I've been curious about the research on GLP-1s for that reason. But I want to talk a little bit about us making natural GLP-1s, you know, people having a different solution outside of a prescription that we don't really know the results of. what could someone do to stimulate their GLP-1 naturally, which would then in turn support them in more healthy regulated blood sugar levels and then reducing hunger and cravings? So now that we know these specific strains that stimulate GLP-1, you have a target to go tackle. So there's two primary ways you can do this. One is you can try to feed those strains, and those are some of the foods that we talked about, the prebiotics like the fibers and the polyphenols.

41:42And the second, you know, that and or the second is to actually just supplement with the strains themselves. So there's sort of you could do the one, two punch, which is, OK, I'm going to supplement with these strains, plus I'm going to feed them. And now you're really going to get a chance to have them colonize to help stimulate your body's natural GLP-1 hormone. And if we were. So I want to walk through again, just like this, how the strains produce the GLP-1. So basically, just to make it super simple. So these two strains that we talk about, acromantia and then the other one that you mentioned that I'm not gonna know, these are what are the building blocks of the hormone that is GLP-1 in our body, correct?

42:24They are strains that metabolize your food and then you have in your, it's actually in your gut lining. So in your gut lining, there are these cells in there. They're called L cells. And when these strains are metabolizing your food, they send a signal to those L cells. The L cells basically house GLP-1, and they're waiting for a signal to then release GLP-1 into your bloodstream. And so what these two microbes do, the Ackermansia mucinophila and the Clostridium budericum, what they do is when they metabolize food, they are the signal that tells the L cell, who's just waiting there for their signal, okay, now release it.

43:00And then the L cells release this. And so they're like the guys who ring the dinner bell. I love your examples. They actually are incredibly helpful. And as a teacher myself, I'm like, I need to have good examples like this. They are amazing. So you at Pendulum are just like pioneers in the space of the gut microbiome and of probiotics. So tell us a little bit about the GLP-1 probiotic that people could take. What does it do? How does it work? And how could this be a natural alternative to these drugs? Sure. Well, so all this scientific research around, okay, your microbiome stimulates GLP-1 release, and oh, there's this particular department, and oh, what are those strains?

43:41All of that science is what our products are premised on. And so the product is literally those strains, those two strains that have been published that show that they can stimulate GLP-1. Plus, we added a third one in that we know that works with those two. And that's what's in here is those probiotic strains. And so the best way to get the most out of this is to take those strains and also increase your fiber and polyphenols in your diet because those are the food for those strains. And the way that this works is it really, what it shows up for you as kind of most clearly are reduced food cravings and improved digestion.

44:20That's kind of the things that people most recognize because you don't really know your blood sugar spikes. I mean, that's why we wear continuous glucose monitors. You can't really feel when these things are happening in a real way, but you can definitely feel your cravings and you can definitely feel when your digestion is off. And so there's actually a diagnostic test called the Food Cravings Inventory. And it's a test that has all these questions about different types of foods. And what we know about cravings is there are four primary types of cravings. And when I tell them to you, everybody usually knows which category they fall into.

44:51There's sugars, carbs, fast foods, and high fat foods. And some people will feel like I have all four. I'd say I'm a sugar, I'm a sugar carbs person, fast food. My mom never let us have fast food. So I didn't sort of build that into my repertoire. And then high fat, nah. Yeah. Okay. So you've got sugars and carbs. And so there are these four primary categories. And so this food cravings inventory, when you finish it, it tells you, okay, across each category, where do you rank on food cravings? And I think it's a scale from like one to four, one to five. So you can get your starting position. And then what we found is that after being on this probiotic with these strains that stimulate your natural GLP-1, after being on this probiotic for six weeks, 91 % of people had a reduction in their food cravings.

45:42And the biggest one was actually for sugar. And then moreover, the higher you started, the more you saw an improvement. So if you're like, oh man, I'm off the charts on sugar, that was where those people saw the biggest improvement. If you're like, well, I don't really have like a big craving for fast foods, you might see a little decrease, but it wasn't much to begin with. So you don't really see as much impact. And so 91 % of people though saw statistically significant reductions in their food cravings with this test. And that starts you on a really amazing cycle. We've all been on the bad cycle, which is I'm sad or I'm, you know, feeling down and I'm eating foods that are bad for me.

46:20That makes me feel worse. And then I feel bad about those decisions that I eat again, you know, bad foods. And you could be on this cycle where it's like you have this, there's definitely a gut brain connection where you, you know, not feeling well causes you to eat poorly, which then causes you to not feel well. And then you're on this cycle. What this does is it breaks you out of that. And now you are not having those cravings and you're feeling really good about your decisions. And that actually causes you to make even better nutrition decisions. And then we start seeing people being like, okay, well, I'm feeling really good and I'm going to have the energy to exercise.

46:51And so you can get onto this really amazing cycle. All it takes sometimes is one little trigger to move you from one hamster wheel to the one you really want to be on where you're in like a really good feedback loop. And so all we're trying to do is to give people those little tools that can really change your whole mindset about your health. when we talk about cravings, I love the breakdown that you guys have of the four. I'm always curious about cravings in the relationship between, um, our emotional and mental state and then cravings of the body. You know, our, our body doesn't crave fast food for the most part, I would say, but we have this emotional, um, emotional relationship with food, mental relationship with food.

47:33So we talk about cravings, how is GLP one sort of impacting this emotional comfort we seek in food? Because a lot of us use food, not just for fuel, it's for something else. Yeah, I think, so first of all, it's not going to all get distilled down into one molecule or one hormone that can change your whole life. But I would say the GLP-1 hormone plays a really important role in this. And in fact, there have been some studies that have come out showing that people who are taking these GLP-1s, it can help resolve addictions like alcohol addiction. That's what I've heard. Yeah. And that's that same part of your signaling.

48:12So it's sort of almost agnostic to what the thing is. You've got other issues or nostalgic things that are leading you to, this is what I'm addicted to. And really what the hormone is doing is what it's triggering to your brain is you don't need, you don't need X, fill in the blank. So pick your poison, whatever that is. What the GLP-1 hormone is doing is it's not guiding you to the poison of a particular thing. There's a lot of other factors that I think lead to what our weaknesses are. But what the GLP-1 hormone is doing is it's basically blocking then those desires. It's essentially telling you like you don't need more.

48:48You're good. You're satiated. You're happy. And so that's why I think we're starting to see that those drugs can work for food addiction, alcohol addiction, drug addiction. At the end of the day, these are all things that are triggered by somehow there's a feeling of emptiness. You're not full. You don't have satiety. And that's what this GLP-1 hormone does is it gives you that feeling. That's so powerful. I was talking to someone, he does market research for financial markets and the drugs have impacted the financial markets so much because they've hit on fast food industry, they've hit on the soda industry, and they're hitting on the gambling industry and the alcohol industry as well, just because of that same reason that it's hitting on the addiction centers of our brain that are addicted to gambling, addicted to fast food, addicted to drinking, all of these things.

49:39And so it's so exciting to hear that we can use something that works naturally with our body in a natural rhythm to support ourselves, whether we want to cut our addiction to sugar or whether we want to stop drinking or, you know, stop gambling even in the future. And I'm excited to see what sort of research could come out to support people in that because addiction really has a hold on so many people in America, especially where they do feel that feeling of emptiness and they're looking outside of them for that support. Absolutely. And I think that as we uncover kind of biologically what are the things that are depleted that are leading to this emptiness, you know, this feeling of emptiness that we're trying to fill with these other things, we start to have real things that we can target.

50:23And GLP-1 is a huge one. And that's one of the reasons GLP-1 drugs have become so overnight, immediately exciting for people is because it's really hitting at a core hormone that is dysfunctional in many of us.

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53:40Yes, a hundred percent. So Pendulum has an amazing GLP one product. Can you tell us a little bit about it? So it's called GLP one. What is it made of? Like, how would people take it? Is it something they need to cycle. Like, how would you suggest people go about thinking about this when they want to break addictions to food? They want to curb their cravings. They want to support themselves. And I'll just say for myself, I've been taking it for the past month and a half since you sent it to me. And it has been so nice to feel like I have support in cutting my sugar addiction. I'm someone that has dessert every day, sometimes at lunch and dinner.

54:18And I'm literally not joking when I say this. I had a brownie last night. It's just crazy. And I want to support myself and kind of having a new way of being where I'm not dependent on finding a sweet treat after everything I eat. And it's just in this really natural way supported that. And it's weird because my association to taking a supplement or a pill to supporting myself and changing my diet has always been related to the diet pills I took when I was very young in high school or college. And it was a jittery feeling. And it was this anxious feeling because it was caffeinated, it was taurine, it was all these weird things.

54:51And it was like this aversion to food, but in this weird way. And to just feel like there's a natural choice that I have now, and a natural pause where I'm like, oh, I actually don't feel like I really don't feel like having it, rather than like, I want it, but I'm so hyped up that I'm not allowing myself to have it. Yeah, I think that's right. Rather than getting yourself all hyped up. So then you don't have like the you're just not thinking about eating, you're distracting yourself. You're like a mess. Literally, like calming the mind. This is about calming ourselves from needing more to fill our plates, literally.

55:28And so and I was just talking with Kevin Rose, who we both know, and he invited me to chat with him because he had and he shared this out, which is that he ran into an old friend. And these days, you know, when you haven't seen someone in a while and they've lost weight, you just sort of assume like, oh, you're on the juice. And so what he found out from her was that she was not, in fact, on the juice. She had been taking this GLP-1 probiotic from Pendulum and that she had reduced literally just like how much chocolate she was eating. And so she said, you know, I used to be someone who I would take a bite of a chocolate bar and then that whole chocolate bar is going to be gone.

56:09Like there's not going to be anything left at the end of that sitting. And that now she really could take a bite and then close it up and then be totally fine, feel totally satiated, feel full from that, and not feel like she had to eat the whole candy bar. And that that was sort of the secret. She really was increasing her body's GLP-1 hormone through the GLP-1 probiotic. And that was giving her a sense of satiety. So she didn't have to eat the whole candy bar. And that got him all excited to revisit like, well, hey, how is this probiotic working? And, you know, how can we help more people improve their GLP-1?

56:47Yeah. Do we, so much like the drug, would we have to be on this? Well, I'm on it now, but would we have to take the, I'm talking about the probiotic, would we have to take the probiotic forever, do you think? Or what would be the long-term usage of this? You do not have to probably be on it forever. And Kevin Rose actually is one of our investors. So I even told him this. I was like, I know you're an investor, but the truth is you really don't have to be on these forever. And the reason is because your microbiome is an ecosystem with all these different strains that is fed by you. And so if you can get these strains to colonize, you can feed them so that they can continue to grow and colonize on their own.

57:29And so now it's going to require probably dietary change. It's going to require a lifestyle change where you're eating higher fiber, higher polyphenol foods. You're avoiding processed foods and all of those things. But if you can do that, you can get these strains to colonize on their own. You don't have to keep supplementing with them. And so that's the truth. So it's basically like we take the beautiful strains through the supplement and then they're in our bodies essentially in a beautiful colony. And if we're feeding them in the right way with the adjustments to our diet, which is the goal and what we always need to do, then they essentially will colonize and continue to replicate and recreate in our body.

58:10Exactly. Exactly. And now one of the most fascinating things about this strain, Ackermansia, is that I think I said earlier, it hasn't been found on any foods or any beverages or anything like that. And so there's always been this question of, it's one of the most important strains in our bodies. It is a keystone strain in our gut. And if you can't find it on any foods or beverages or anywhere, like how do we get this? And why do we have so much of it in a healthy gut? There's only been one place that acromantia has ever been discovered, and that is in mother's breast milk. And so the theory is now you get your acromantia from mother's breast milk, and that's your starting amount.

58:50And for the rest of your life, if you're not feeding that, You're not colonizing that. You're losing it. And because it's a keystone strain, as you start to lose it, it shows up in these inflammatory responses, immune diseases, obesity, metabolically unhealthy, GI issues, food sensitivity. So all those things start to show up. But it's all like starting from mom. And then your job is to keep that thing alive through your food. Wow. I'm going to research. I would just wrote that down because I'm like, I'm going to research the difference between when you're breastfed and not breastfed and all of the impact, because that's so fascinating because then you having the acromantia from a mother's breast milk impacts so many other different areas in your life in the future.

59:34And again, this is not to shame any mothers or anything like that. It's just, I'm curious, you know, how that leads to such a trigger point down the line. So where do you guys get your acromantia then when you have, because you have a probiotic with just Acromantia that I've taken. It's amazing. And then you also have this in the GLP-1. Where do you guys source it? We manufacture it. So essentially it's originally sourced from a human and then it is isolated. And then we just, we manufacture it as a single strain and that is how we make it. And I would say also that I also just want to second, like this isn't a shame thing.

1:00:12This is actually a story of hope so that you, for whatever reason, you can't breastfeed. you have an opportunity to still get your kid this acromantia. And if you were someone who didn't have breast milk and you're thinking like, oh, my gosh, this is my I'm low in acromantia, you can actually get it back into your bodies. And so this is really a story of hope. And and one last thing is even if you are breastfeeding, like I have two children and I worked and I had to pump breast milk and freeze it and then thaw it and feed it my kids. And I am like a relatively impatient person. And so if you've ever had to heat breast milk, you know, there's like several settings, that little knob of how hot the thing gets.

1:00:52And I would just put that thing on high. And then I just throw the frozen breast milk in there and be like, all right, how soon? Just fry it. You just fry it. And I was just like trying to get this thing as fast as possible into the kid. And now when I look back on that, knowing what I know now about what's in that breast milk, I'm realizing even though I was pumping breast milk and giving this to my baby, I was killing all the probiotics in there. Every strain that was in there was certainly dead by the time I took it out of that boiling thing and gave it to my kid. And so there are a lot of reasons why we've, you know, maybe not delivered the amount that we wanted to people, but you can give it back.

1:01:31And just remind me, acromantia, what are the benefits of having acromantia outside of its relationship to GLP-1? So there's two big things that acromantia does. One is the stimulating GLP-1 hormone that we talked about. And the other thing, and this is probably actually maybe even the more relevant thing, it plays a really unique and important role in the actual structure of your gut lining. And so your gut lining is, we'll do another analogy here, is like a wooden fence. You know, if you look at a wooden fence, you have all these planks and they're held together by glue. but what can happen over time with your wooden fence through weather and seasons is that that glue can start to weaken and a plank can fall and now you've got a leaky fence.

1:02:18Your gut lining structurally is literally exactly the same where you have these cells, these epithelial cells, and they're held together by glue which is called mucin. And acromantia is the only strain that has ever been discovered that lives right there at that fence and its job is to strip away the old glue when it gets old and to put up new glue. So it's literally always getting rid of the old glue and putting up new glue. That's its job is to regulate the glue of the fence and to keep that fence strong, to keep your gut strong so you don't get kind of these leaks in your gut lining. And it's the only strain that we know that does that.

1:02:52We don't know anybody else who does this. And so that's another reason why it's a keystone strain, because if you are missing it and you literally don't have the physical structure of your gut lining intact and you have these gaps, We know this leads to inflammatory responses, immune problems. You just essentially have all these things in your microbiome leaking into your bloodstream and all these things in your bloodstream making their way into your microbiome. It's just a hot mess. You need that fence there. And so acromantia keeps your fence strong. Wow. And for maybe the GLP-1 or even related to acromantia, we mentioned a study that you were talking about before related to cravings.

1:03:30Is there any other cool studies that you guys are doing? So we are doing a few different studies. One of them is we are actually testing this product in people to see whether you can see their GLP-1 levels go up. So you know how I said your GLP-1 is supposed to be on the cycle. It's actually really hard to catch it to know is it actually going up. But we're trying to measure that and see whether a person could demonstrate to themselves that their GLP-1 levels were actually more, they were back on this like good cycle. And so that I'm super excited about. And we probably have about a dozen different studies going on.

1:04:07Another one that I'm really excited about is not with the GLP-1 product, but actually with Pendulum Glucose Control. So Pendulum Glucose Control is everything that's in GLP-1 plus two additional strains. It's kind of like our highest dose clinical formulation for people with diabetes. Well, there's a group in Australia that is taking that pendulum glucose formulation and they are testing it in post-menopausal women for bone health. And the idea is that actually your microbiome plays a role in your bone health. And this for me is super interesting because after women go through menopause, their whole bone density is really, really a problem.

1:04:50But we all know that way before you enter menopause, you're supposed to be working on your bone health. We're supposed to be getting enough calcium. We're supposed to be building up muscle around all of our bones. We're supposed to be doing all this great stuff. You know, what if earlier on you could really be helping with your bone health and then you kind of are able to do that all the way through? So that one I think is really interesting. Yeah. I mean, the ways in which we're confirmed how the body works as a system, like every single study all the time, it's like, it is so interconnected.

1:05:20We cannot deny it. But I'm really excited about this. We've just been so impressed by your products always and the research that you do and the thoughtfulness. And I always love hearing you as a teacher and to hear about this as an option for people, like a GLP-1 probiotic as a way to support them is just so exciting and incredible and makes total sense to me. It's been really great for me to take it. I'm excited for our audience to dig in. Is there anything else you want to leave our audience with today as it relates to this or anything else you feel like we didn't cover that you'd love to share?

1:05:54I think the only thing I would say to people is that when you're trying to approach these natural systems, so when you take this probiotic, if you're comparing to the drug, it's not gonna be like that. You're not gonna take it and then six hours later be like, now I'm nauseous because I'm hammering my body with this drug. So I would just say to people, be patient. I always say like, give it 90 days. So do a 90-day challenge for yourself. Try the product for 90 days and see whether you have an improvement in your food cravings. But when you teach your body to do things naturally, the bad side of that is it takes a second.

1:06:31The good side is that it lasts. And so you kind of have to take the good with the bad. So just the patience part for this to kick in is the main thing I would want people to remember. I love that. I think for people that really want the change, we got to be patient. We got to be, you know, we got to be on. And I think for anyone that wants body change or body transformation, it's always the patience. That's who we're really working against. So I think that's really beautiful. But it was such a pleasure talking to you. Our time absolutely flew. I was like so in it. I love, again, what you share.

1:07:03And I'm really excited that I'm able to take this and that you guys were able to make this and all the things that you do with such integrity and such class and just with the right intention. So I really appreciate you coming on Almost 30 every time I get to talk to you. Oh, thank you so much for having me and for spreading this information to everybody because it's an exciting time, all the stuff we're learning about our guts. Yes. And keep me posted on new research and I will talk to you soon. Thank you. Bye. Thank you so much, Colleen. Again, you can get the GLP probiotic from Pendulum by going to PendulumLife.com slash GLP one and using the code almost 30 at checkout for 20 % off membership first orders.

1:07:47Amazing. Thank you all so much for listening. Thank you to everyone who has purchased our new book, almost 30, a definitive guide to a life you love for the next decade and beyond that you can get our book. If you haven't already at almost 30.com slash book. Okay. I'll see you on the next one. See you soon. Love you guys. Bye.

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