Trump Aims to Seal Iran Deal, Says Truce Extension Unlikely

20 Apr 2026 · 40 min · 22 chapters

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In short

The episode covers three fast-moving topics: (1) U.S.-Iran ceasefire and nuclear negotiations, (2) macro/market implications of the war and interest-rate expectations, and (3) AI chip competition plus psychedelics regulation.

Guests and backgrounds

Jeff Mason (Bloomberg Washington/White House correspondent). Rich Weiss (CIO, Multi-Asset Strategies at American Century Investments; ~$330B AUM). Dina Bass (Bloomberg AI infrastructure reporter). Kabir Nath (CEO of Compass Pathways; synthetic psilocybin COM360 trials).

Key claims

Trump says a two-week truce extension is “highly unlikely” without an agreement; U.S. straight-up sanctions remain blocked until an accord. Weiss argues markets are “looking through” the war; politics/midterms drive expectations; rates likely fall, possibly via Fed rationale and even yield-curve control. Bass reports Google likely to announce a TPU for inferencing (fast responses) at its Las Vegas conference, challenging NVIDIA’s dominance in fast inference. Nath says Trump’s executive order accelerates FDA/DEA pathways via expedited review vouchers and DEA status changes; Compass is ahead with late-stage COM360 in treatment-resistant depression and PTSD.

Notable examples

Iran sending negotiators to talks in Islamabad; oil/Brent around ~$95; Weiss cites demand destruction and GDP forecasts ~2% real; Bass mentions Marvell rally on Google chip discussions; Nath cites 25% and 40% symptom response after one administration and durability up to six months.

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

Tap a time to open that second in VO

Trump's Position on the Iran Truce

1:55 to 3:30

Discussion on President Trump's comments regarding the Iran ceasefire and negotiations.

“Well, noting that the straight-up form moves would remain blocked until an accord is finalized.”

Iran's Response and Negotiation Dynamics

3:30 to 4:15

Exploration of Iran's pushback and the dynamics of the negotiations.

“This is just one side of the negotiations.”

Trump's Communication Style and Strategy

4:15 to 5:30

Analysis of Trump's direct communication with reporters and its implications.

“But interesting nonetheless, as you rightly say, Carol, that a lot of what the president was saying last week ended up either not being confirmed or directly contradicted by Iran.”

Impact of War on Financial Markets

5:30 to 7:10

Discussion on how the war affects stock market performance and investor sentiment.

“So I think it's I think it's just a part of who Donald Trump is.”

Market Reactions and Political Implications

10:11 to 14:00

Discussion on market reactions to political dynamics and upcoming elections.

“Listen on Apple Car Play and Android Auto with the Bloomberg Business app.”

Equity Market Expectations

14:00 to 15:00

Discussion on how political stability influences equity markets.

“And you think equities, let's go to the equity markets first, that they're rallying on those expectations that Republicans will be back or can maintain power.”

Interest Rates and Economic Growth

15:00 to 16:10

Exploration of factors affecting interest rates and their impact on growth.

“But that's not what the Fed chair's responsibility is, right?”

Treasury Strategies and Yield Curve Control

16:10 to 17:20

Examining potential Treasury strategies and their implications for the economy.

“lowering rates despite inflation being problematic at the current time.”

Spending and Economic Sustainability

17:20 to 18:20

Debate on government spending priorities and their economic effects.

“It's something we've done before where you pull down not only short-term rates, but long-term rates.”

Taxation and Revenue Challenges

18:20 to 19:50

Discussion on the challenges of taxation and government revenues.

“This is not a new problem, but it does look like it's getting unsustainable.”
Show all 22 chapters

Oil Prices and Economic Impact

19:50 to 21:00

Assessing the implications of rising oil prices for consumers and the economy.

“That was certainly the hope at the time.”

Investor Strategies Amid Uncertainty

21:00 to 22:40

Advice on investment strategies in the context of ongoing geopolitical tensions.

“Depending on where you are in your life cycle, what you're going to do.”

Google's Chip Innovations

22:40 to 24:50

Insights into Google's upcoming chip developments for AI and inference.

“We're interested in what Google is up to and what they've been doing.”

NVIDIA vs. Google in AI Chip Market

24:50 to 28:00

Analyzing the competition between NVIDIA and Google in the AI chip sector.

“Google's chief scientist, Jeff Dean, you know, told me in an interview, look, you know, there's all this demand growing for fast inferencing.”

Google vs NVIDIA: The Chip Dilemma

28:00 to 30:08

Explore Google's strategic decisions in the chip market compared to NVIDIA.

“But also, even more than that, they have to decide what they want to do and what they want to be.”

Trump's Executive Order on Psychedelics

32:58 to 33:59

Analyze the implications of Trump's order on psychedelics for mental health treatments.

“Catch us live weekday afternoons from 2 to 5 p.m.”

Compass Pathways and Treatment-Resistant Depression

33:59 to 37:50

Delve into Compass Pathways' progress in treating depression with psilocybin.

“If these turn out to be as good as people are saying, it's going to have a tremendous impact on this country and other countries, too.”

The Impact of the Executive Order on Treatment Access

37:50 to 40:31

Understand how the executive order may expedite access to psychedelic treatments.

“anything, whether we're talking about GLP ones, you know, it's not like you take one shot and you don't have to take any more again.”

Differentiating Compass Pathways in Psychedelic Treatments

40:31 to 42:01

Explore how Compass Pathways stands out in the competitive psychedelic treatment landscape.

“No, I was just thinking, though, as you were saying that, you know, expediting everything, And that includes, I was thinking, Tim, coverage by health care as well.”

Exploring Psilocybin Therapy

42:01 to 43:36

Learn about the distinct therapeutic experiences and potential of psilocybin.

“First, we are significantly ahead of other companies.”

Clinical Trials and Regulatory Standards

43:36 to 44:56

Discover the rigorous standards Compass Pathways is applying to its clinical trials.

“And they cited the quality of research and questions over the clinical trial design.”

Market Reactions and Stock Performance

44:56 to 45:59

Analyze the impressive stock performance and market reactions surrounding Compass Pathways.

“We believe strongly that the data we've shown on efficacy and safety is compelling, but ultimately it is the FDA's decision as to whether to approve.”
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Transcript

Automatic transcript. May contain errors.

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1:29Carol Massar:News.

1:54President Trump said it's highly unlikely he would extend the two-week truce if an agreement is not reached before it ends. Well, noting that the straight-up form moves would remain blocked until an accord is finalized. Brent Crude hovering just around$95 per barrel. President said that to Bloomberg News Washington and White House correspondent Jeff Mason, who caught up with President Trump earlier today. Jeff Mason is back with us from Washington, D.C. Jeff, great, great piece out on the Bloomberg terminal, on Bloomberg.com about your call with the president. Take us back there earlier today and sort of how this went down and what you learned from him.

2:28Sure. Yeah, I appreciate that. I gave him a call this morning. He picked up and we started talking about the war. And obviously, the key question right now is about the ceasefire because that deadline is initially we thought it was tomorrow. The president told me it was now Wednesday night. And him saying that he's not likely anyway to lift that ceasefire unless there's a deal certainly adds another level of urgency to talks in Islamabad in the next couple days. So that was certainly a big takeaway. Also, again, the fact that he said he was not in a rush to get a deal, that felt like a shift from what he said last week when he was basically describing a deal as already being done.

3:11I would always caveat what the president says to me or says publicly otherwise, that this is a president who likes to give mixed signals. And those mixed signals often are related to a negotiating tactic. So lots of questions still, but certainly interesting in terms of where he seems to be today in his thinking.

3:30Carol Massar:This is just one side of the negotiations. And we want to talk a little bit more about this call that you did with the president. But I do think about Iran. it seems like that they continue to push back on some things and certainly with what the president says, Jeff. Yeah, there's been a lot of pushback from Iran. What is interesting is, and this is in the story on the terminal as well, is that some officials did indicate to our Bloomberg colleagues that Iran is going to send some negotiators to that negotiation. That was kind of up in the air over the last few days and seems to have still been up in the air for a while.

4:03So interesting, at least that there's not going to be a scenario, at least as of right this minute, where U.S. negotiators show up and don't have counterparts to talk to. But interesting nonetheless, as you rightly say, Carol, that a lot of what the president was saying last week ended up either not being confirmed or directly contradicted by Iran. The president's been very active on True Social, on his social media platform lately. I think that's, I could probably say that any day over the last 18 months, Jeff. Or longer. Or longer, fair. He does tend to sometimes call into TV shows at various different networks.

4:46He'll speak to the press. As you know, you're there for most of those. What does it mean to you when he goes one-on-one with you, for example? What's the message that he's trying to send? Well, I don't know how to interpret that exactly other than to say I think he does like not having the filter that a White House would normally put around the president. And certainly all the other White Houses that I have covered have had that filter. So this is someone who is accustomed to reaching out to reporters directly or receiving their calls when he was a New York businessman. And he has brought a little bit of that flavor to this second term, a little less so in his first term, but quite a bit in the second term.

5:27And he even said to me this morning when I called that he likes having that direct line. So I think it's I think it's just a part of who Donald Trump is. And it's got to be a little bit tricky for his comms folks and probably also for the Secret Service, knowing that he's he's having these calls on on his cell phone. Hey, Jeff, I do wonder, too, did I can only imagine I can't imagine.

5:55Carol Massar:It is unlike any other White House, I think it's safe to say, in this direct line. The financial markets, any of that come up in the call? You know, we've often had, and we've often had discussions, I think, with you and others, just about how we do believe that the president keeps a watch on what's going on in the financial markets. And they seem, you know, pretty calm. Yeah, stocks are down a little bit. Energy, oil is up a little bit. But, you know, I'm just curious if any of that came up. We didn't talk about financial markets. The call was focused primarily on the war. But I think it's a good question, and I think you raise a good point.

6:32This is something that the president clearly does watch. And honestly, on sort of a macro level, the war has taken away a lot of the talking points that the president likes to use. He likes to talk about the records that the stock market had reached during this second term. He likes to talk about having been responsible for bringing gasoline prices down. Those stock market records are nearly back, but the fuel prices are still very high. And as we have certainly talked about before, that presents a great deal of political risk for him and his Republican Party going into the midterm elections in November.

7:10Carol Massar:Yeah, absolutely. It was a big topic of conversation that we had earlier with one market guest. Jeff, thank you so much. Really appreciate it. Jeff Mason, Washington and White House correspondent there at Bloomberg News, joining us from our D.C. Bureau. Stay with us. More from Bloomberg Businessweek Daily coming up after this.

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10:15Or watch us live on YouTube.

10:18Carol Massar:Not the weekend that we thought it was going to be, Tim, when it comes to the U.S. war in Iran. I think we thought there were going to be talks and progress. It didn't exactly play out that way. Yeah, but it kind of reminds us that things can change in a minute. Absolutely. Exactly. Exactly. That's where we are. I, in fact, am surprised we're not seeing a bigger market reaction. Yeah. Well, I think, you know, it's an environment we keep talking about that investors look kind of for a reason to buy, certainly on the equity side of things. But let's see what our next guest has to say. In fact, looking through his notes, he points out that repositioning now depends on as much as your personal situation as it does on the macroeconomic and geopolitical environment.

10:53Carol Massar:Great to have back with us. It's been a while. Rich Weiss, he's Chief Investment Officer of Multi-Asset Strategies at American Century Investments, which has about$330 billion in assets under management. He's back here in our studio. Hello, hello. It is good to have you here. It's great to be back. Good to see you both. Tell me about this environment and how you see it and how you keep thinking about the war. Do you feel like we should be looking through it at this point? I'd say the market's looking through it pretty clearly. And as far as the war is concerned, if someone's looking to bet on the war, its duration or severity, or bet on oil prices, go to Calci or Polymarket and make your bet there.

11:27Don't rejigger your longer-term investment strategy on that kind of element. But yeah, I think there's one explanation for why the market is hitting new highs despite low consumer confidence, inflation expectations up, inflation up. Most economists are ratcheting their expectations for real GDP this year downward. How could the stock market be hitting new highs? The one explanation is politics. It's the midterm elections. I mean, if there's one thing they're concerned about, they have to get this war resolved in order to keep at least one house, if not two. I'm talking about the Republicans. So I think that's paramount here.

12:08That's what the market is looking at. That also explains why Fed funds futures can't seem to decide whether rates are going up or down. They're clearly going to go down. So let's start with the markets, because in other words, you're saying that investors are betting that Republicans will end the war, ASAP, get energy prices down so inflation expectations come down ahead of those November polls? Well, it'll take a little while for oil prices to come down, maybe weeks, months, right, just to get production rammed up. It's pretty risky politically. But to get an end to this or some kind of truce in place, because as it keeps going, it's just a debacle.

12:49One thing on that, though, is that I think that it's challenging because, as Iran has indicated, giving up enrichment doesn't seem like it's going to be one of the concessions that the country would offer. And it seems like the president doesn't want anything short of that. We just spoke with Jeff Mason in Washington, who said the president wasn't a fan of any timeline delaying or stopping enrichment for five years, 20 years. He wants to see forever. And with all due respect, the president says a lot of things, which then reverse the next day. So the president said he's under no pressure. I'm not sure that's the case.

13:27I think the Republican Party, the White House, the administration is under quite a bit of pressure to get this result by their own party. OK, for real humanitarian reasons, but also for political reasons.

13:39Carol Massar:Rich, I think it's interesting because I think there's an expectation. There's a lot of folks, some momentum based on some of these, you know, elections that we've seen in different states, in different areas around the country where Democrats have either won or put in a strong showing. And I think there is a line that's being pulled through to November in the midterms thinking that, okay, that the Democrats are going to be back in power. That's not a given in your view. And you think equities, let's go to the equity markets first, that they're rallying on those expectations that Republicans will be back or can maintain power.

14:15Right. At least one of the houses, right? That they won't lose both. And that's an imperative there is that to find some resolution short term or otherwise for this conflict in the Middle East.

14:26Carol Massar:So let's go to, you said clearly rates are going to go down. Why? Why do you say that? Because of the growth slowdown or what? A combination. But I believe one, again, political pressure, bringing rates down, lowers borrowing costs. It gooses the economic growth, potentially gets the housing market restart. So it's good for Americans to get interest rates down for business investment, et cetera. So it'd be a great thing if they could do it. I believe the administration, the president wants that to happen. I assume Kevin Walsh will be placed. But that's not what the Fed chair's responsibility is, right?

15:06Carol Massar:It's to look at inflation, look at employment. That's the dual mandate. And then figure out the right policy. And it's not only always comfortable. Just go back to Paul Volcker and ask him. It's not always comfortable what you have to do as Fed chair. So what is more important to have a Fed chair that looks at the data and does the right policy or succumbs to the White House? I believe he can do both. Why? Why? Because you can come up with a viable economic rationale for lowering rates, which is what his mandate is going to be from this president who handpicked him. He's at a central casting. I think the president said that himself.

15:45And the economic rationale is inflation is an existential threat and is causing demand destruction. I think that's the phrase to look for or listen for. Demand destruction. You already see it happening. economists are lowering their GDP forecast for this year now to somewhere around 2 % real GDP and maybe even lower as this conflict continues. So there is a viable economic rationale for lowering rates despite inflation being problematic at the current time.

16:16Carol Massar:But then don't you worry that by lowering rates and creating even more liquidity in the market that you drive inflation even higher? And so you get to that point where we have stagflation of lower growth and higher inflation, which is not anything that anybody wants. Well, the hope there is you'll spur economic growth, right? And so inflation then is a secondary effect, which you'll take care of afterwards. That's one hypothesis. I firmly believe rates are coming down with this new Fed. Well, that's the Fed side of this. What about the Treasury side of this and yield curve controls? Yeah, I think, well, there's, I described, you know, the Fed is the left hand of the president and then treasury's the right hand right and president's a good fighter and a one-two punch secretary besant uh when he came out a while ago didn't he call he referred to the u.s i think it was as insolvent which i'm not i'm not sure that's a pretty strong word i mean we're not bankrupt right but i think he was referring to the fact that interest expense now is at a level where we can't support it with current annual revenues so it's a fair definition but secretary besant may come out and could pair with Kevin Walsh or the Fed and implement what's known as full yield curve control.

17:27It's something we've done before where you pull down not only short-term rates, but long-term rates. We did it in World War II. It helps spur the economy. It lowers your debt expense or interest expense. It's a wartime maneuver. Japan did it. I think Australia did it recently. It's problematic when you do it when you already have inflation because it can be inflationary. Again, back to that problem. But it's very likely or possible Secretary Besant will also move to lower rates to help the economy lower the debt burden. And that's good. How about not spending less?

18:02Carol Massar:How about spending less? Why does this always come up, Carol? I mean, no offense, but I mean, you do a lot of deep dives. Hank Paulson, David Weston. We talked about this last week. Doing a great interview with him, you know, saying you have to, what is it, you know, have shatter glass, like broken glass to deal with where we are headed. This is not a new problem, but it does look like it's getting unsustainable. And especially when you look at the president's plan spending of, was it 2.2 trillion? I think it is. And about one and a half on defense. Are we a war economy now? Are we, you're cutting on all the other programs.

18:42Carol Massar:Is this America today? Well, I'm afraid so. You know, it's a tough, you know, I'm glad it's not my job to figure it out. But do you know what I'm saying? When you're spending on so much of that and you're not spending on some other programs that are important for many citizens and social programs, but also, you know, that feeds back into the economy. Certainly. And this is the old right defense versus social programs. The old red, red, blue debate. Right. And far be it from me to solve that one. So I think the numbers I saw were something like 25 percent of Social Security and or Medicare would have to be cut in order to get the debt burden and the deficit back in line.

19:25Now, that's a nonstarter. Right. You know, because you know who really votes?

19:30Carol Massar:People who get Medicare. Well, there's all the other side of the equation is taxing. And that's also another political third rail. You know, you're not going to find anyone who's going to come in there and raise taxes. But there, you know, there is the tax bill that the president passed through last year. And I'm wondering if the country will be able to pay for that with growth rather than through revenues. That was certainly the hope at the time. I'm not sure it's it's coming out that way now, especially with the war and the oil prices now, which are essentially taxing Americans, even though they are getting refunds from the one big, beautiful bill.

20:11So one's canceling the other out at this point.

20:14Carol Massar:Well, and the Secretary of Energy, Chris Wright, talked to, I believe it was CNN, and said that he kind of undercut President Trump's earlier claim that price increases in terms of gas prices would be short term. And he said that they may stay above$3 until 2027. I mean, that's something that certainly impacts a lot of Americans. Yeah, well, oil prices, again, if the strait were closed tomorrow, right, it would still take weeks or months. If it were open tomorrow. It would still take weeks or months for production to really ramp back up. So, you know, envisioning oil below$70,$80 a barrel, that's not happening for a while, no matter what happens politically.

20:51Carol Massar:So 30 seconds. I love this macro, deep, deep thought. What do investors do here then? Just quickly. Well, first of all, don't bet on when the war is going to end. That's not a smart move to make. Depending on where you are in your life cycle, what you're going to do. If you're a young investor, you have many years to put money in the stock market, you're earning, you buy on these dips. I mean, if you have a 20, 30-year horizon. On the other hand, you're a retiree or near retirement, and you're already maxed out in equities because the equity market's been so strong the last few years, good time to get out or move out.

21:26Because you can't suffer another 20 % if that were to happen.

21:29Carol Massar:We've talked to Rick Worcester of Schwab, the CEO, and he has said that you do see the younger folks buying on the dips throughout this war. Rich Weiss, Chief Investment Officer of Multi-Asset Strategies at American Century Investments.

Read the full transcript

21:59Alexa, play Bloomberg 1130.

22:03Carol Massar:I want to just pull up shares of Marvell Technologies because that stock has been on a bit of a rally today. Yeah, it's pretty much near its highs of the session, up about 6.4%. This is after the information reported that Google is in discussions with this semiconductor company to develop two new chips to run AI models more efficiently. And then we have our own Dina Bass of Bloomberg reporting out that in a matter of months, Google's AI chips have become, Tim, one of the hottest commodities in the tech sector. Yeah, this leading artificial intelligence developer, some of the firm's biggest rivals are actually stocking up on them.

22:37I was also just looking at shares of Marvell this year. Yeah, what are they doing? Up 75%.

22:41Carol Massar:Not too shabby, right? Yeah, not too shabby. A little outperformance there. I think that's fair to say. Let's get more, though. We're interested in what Google is up to and what they've been doing. It's not just recently, but for a while now. With us is Dina Bass, Bloomberg News AI infrastructure reporter. She joins us from Seattle. Hey, Dina, great reporting. interesting story. It does feel like, though, increasingly we're in this world where these big tech giants want to make and are making their own semiconductors. Tell us about Google, because they've been, what, designing chips for over a decade.

23:12Carol Massar:But what's interesting about what they are doing right now? So, first of all, you've mentioned in a matter of months, let's talk about what's likely to happen in a matter of days. Later this week is Google's next conference in Las Vegas. And as we reported in our story, they are likely to announce at that conference that they are releasing a version of their trip, a TPU, for inferencing workloads. So inferencing is when you've already got an AI model that's trained and you need to run it. You need to enable it to answer people's questions quickly. So we're reporting they're probably going to announce a TPU for inferencing.

23:51And that would sort of, you know, as you mentioned, individual companies doing things, you know, some of what's gone on in the last couple of months also is this focus on, you know, low latency or very fast inferencing. So if we're getting into a world where people are looking at agents and things that need to be more conversational, you want to be able to answer those queries quickly. And so last month we had NVIDIA, which is obviously the giant, the dominant player, releasing a fast inference chip based on the technology they acquired from McGraw. I know, you know, Cerebris just filed their IPO.

24:27They're also in this fast inferencing space. And so now we're expecting that Google is going to get more fully into that space with a chip that's specific for that task. Whereas up until now, as NVIDIA had in the past, Google has been, you know, using one set of TPU model for both training and inferencing. So that's what we're expecting, you know, later this week. Google's chief scientist, Jeff Dean, you know, told me in an interview, look, you know, there's all this demand growing for fast inferencing. And he said, quote, it now becomes sensible to specialized chips more for training or more for inference workloads.

25:03You know, that said, the head of their chip division, Amin Vedat, declined to say specifically what they're going to do later this week. But, you know, he did say that more will be shared, you know, quote, in the relatively near future. OK, so before we get to the relatively near future, we're here in the now and we have what you've reported, which is just absolutely amazing. And I'm curious about NVIDIA and the competition that this could or potentially would pose to NVIDIA, which, as you mentioned and we all know, is the market leader when it comes to this stuff. So I think you have to remember that it's not just that NVIDIA is the market leader.

25:37Everyone uses NVIDIA. That everyone includes Google. You know, Google's latest Gemini model, however, which has been very well reviewed and very successful, was trained on TPU and uses TPU for inference. Now, last week, there was a podcast with NVIDIA CEO Jensen Wong and Dorkesh Patel in which Jensen talked about the TPU threat and said, look, the growth in TPU is all anthropic, which is a huge, obviously, huge Google TPU customer. But, you know, Jensen's argument was, look, this is not a phenomenon. It's a one-off customer. You know, I spoke to Damasco, Google DeepMind CEO, and, you know, he pushed back on that.

26:18He said a lot of customers do want to do what Google does, which is use both GPU and TPU. And in fact, the problem for Google is that they don't quite have enough supply to meet that. We talk in the story about some other customers, about Meta, about Citadel Securities. But Demis' comment is that they don't have enough supply to meet all the interests. And so for now, at least, they're prioritizing the really high end, you know, frontier model teams who he said really are, you know, best able, best skilled to take advantage of the, you know, the advantages that TPU brings. And then, you know, we talked a lot about what those advantages are.

26:54I think from Google's point of view, what helps them is the fact that they co-design the TPU chips with both the hardware team and the folks at Google who work on those leading AI models. And that gives them a view into what you need to successfully, you know, design a chip that trains and inferences great models. It also helps them see problems more quickly. You know, they argued to me.

27:20Carol Massar:Does NVIDIA need to be worried here, Dina? NVIDIA is still the dominant player. You know, everyone that I talk to expects them to be the dominant player for the foreseeable future. I don't know that it's I think there's a different metric of success for for Google TPU and NVIDIA. NVIDIA success looks like continuing to dominate the market, starting to pick up some of these newer growing workloads in a significant way, such as the fast inference. TPU is coming from a place of being so much smaller in terms of share. It's really more a question of, you know, can they pick up some share? But also, even more than that, they have to decide what they want to do and what they want to be.

28:07NVIDIA sells chips for companies to use in their own data centers in whatever way that they want. Google has thus far almost exclusively focused on giving you access to TPUs through their own cloud. Now, they're starting to experiment with some other models. You know, Anthropic, for example, has been able to, you know, do with Google some experiments where they're running TPUs for Anthropic in data centers that Anthropic controls rather than through Google Cloud. But Google has to figure out, do they want to be a chip seller like NVIDIA that's not tied to their cloud? And then also with that limited supply, how do they allocate between customers who want a certain amount and not everyone can get what they want, as well as all of the Google workloads that are using the TPUs?

28:51and, you know, including Gemini, including Google search. You know, that's also a question. They sort of have to figure out where they want the business to go. It's not quite the same thing as NVIDIA. Why? And just we only have about 30 seconds left, Dina, but why sort of this this identity question? Like, why wouldn't Google try to do both things really well? I think it's just a question of where they want to go and where they want to invest. NVIDIA is, you know, a chip company that also does some AI models and they do some some of the new ideas ai models are increasingly excellent they're very open source focused but they're a chip company coming at that space google is a company in a lot of different areas including you know cloud and search and ai models before they're a chip company i think they have to figure out how what the chip portion uh you know where that fits in and how it helps them

29:40Carol Massar:sounds like tbd and let's see what we get out of the internet what are you just real quickly uh 10 seconds. The announcement. So just the detail, the devil in the details or what? I think we'll have to see what they say and when they're available. And, you know, again, this is, you know, next starts on Wednesday. So keep your eyes peeled for what they say. We certainly will. And we'll be looking out for your reporting as well. Dina Bash, she's Bloomberg News AI infrastructure reporter joining us from Seattle. Stay with us. More from Bloomberg Business Week Daily coming up after this.

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32:51Here today, roam tomorrow. Join now at Sonesta.com. Terms and conditions apply. You're listening to the Bloomberg Business Week Daily Podcast. Catch us live weekday afternoons from 2 to 5 p.m. Eastern. Listen on Apple CarPlay and Android Auto with the Bloomberg Business app. Or watch us live on YouTube. Check out shares of Compass Pathways right now. ADRs, I should say, up more than 42%. They were up as much as 53 % earlier in the session. This after President Trump signed an executive order that directs the FDA to issue expedited review vouchers to psychedelics with a so-called breakthrough designation.

33:29It shortens the review time to one to two months from six to 10 months. Here's President Trump on Saturday in the Oval Office. Today, I'm pleased to announce historic reforms to dramatically accelerate access to new medical research and treatments based on psychedelic drugs. In many cases, these experimental treatments have shown life-changing potential for those suffering from severe mental illness and depression, including our cherished veterans. Our veterans have a tremendous hard time. If these turn out to be as good as people are saying, it's going to have a tremendous impact on this country and other countries, too.

34:09There you have it, President Trump on Saturday in the Oval Office. Compass Pathway is not the only stock that's moving on this. Look at this. You've got a Ty Beckley up more than 22%. GH Research up 17%. Defining Therapeutics up more than 2 % right now. I want to go to Kabir.

34:28Carol Massar:If you look at the advisor share of psychedelics, ETF2, that too, which pulls in all of them up. I'm looking at it right now. Up about 10%. Talia pulled it up. Yeah, nice job. 10.6%. You should do that as one of your gainers today. In fact, it is. Okay. Kabir Nath is watching this closely. CEO of Compass Pathways. He joins us from London. Kabir, welcome back. It's good to have you back on the program with us. I want to talk about this executive order and what it means for Compass Pathways. First, you, though, are using synthetic psilocybin for treatment-resistant depression, TRD. I just want you to remind everybody on where you are in terms of clinical trials, where you are with exactly what you're treating, availability, and that sort of thing right now.

35:11And then we'll talk about the EO. No, thanks very much. and it's a great pleasure to be back here with you both. So we are studying synthetic proprietary form of psilocybin, COMF360, in treatment-resistant depression. That's depression that does not respond to at least two drugs. That affects 4 million people in the United States, and these are people who have had no real treatment options until relatively recently. We're also studying it in PTSD, which affects more than 13 million people. A couple of months ago, we put out the results from our late-stage studies, our two late-stage studies, which showed both of those studies that for a significant percentage of patients, there was a clinically meaningful response in terms of their symptoms of depression based on just one or two administrations of Comp360.

36:06So we're redefining what rapidity and durability can look like with this medicine. We have discussed those findings with the FDA, and we're engaged on working with them so that as we generate more data, we can submit it to them for that review. So that process is already well underway with a view to potentially completing that regulatory submission later this year.

36:32Carol Massar:So, Kabir, one thing I want to go back to what you said, significant results. What does that mean, significant, as a result of the studies? And is it lasting? Is it something that once this is done, I hate to say a person's cured, but I would like to say a person's cured, that they will have a different health trajectory going forward. So, can you just address those two? Absolutely. So, what we showed in one of the studies was that a quarter of all patients had a real meaningful reduction in their symptoms from just one administration. In the second study, that goes to 40%. And to your point on durability, what we're showing is that from just one or two administrations, one or two sessions with psilocybin, that can last out to six months.

37:20So while this would not be characterized as a cure, what that suggests is for many patients, maybe just two or three or four sessions a year can keep them well over the long term. And again, compared to anything that's available for this population, and again, these are patients with this chronic recurrent depression, people who have typically been failed by multiple medicines over the course of their illness, this truly is transformational and game-changing. And look, I'd also remind people that, you know, when we think about treatments such as this for anything, whether we're talking about GLP ones, you know, it's not like you take one shot and you don't have to take any more again.

38:02Or, and one doctor told me with regard to, uh, comparing GLP ones to like exercise, for example, you know, to stay fit, you have to keep going to the gym over and over again. So, you know, you can think about treatment like that.

38:15Carol Massar:And listen, I do think about this could be, or, cause I think we all know people who have either been in a tough way and numerous medications just don't do it. And so if you can actually help somebody live a more normal or a normal and healthy life and feel good, it's a game changer for them. So let's go to the executive order. I believe on the executive order, you said that Saturday's order was a quote, important step forward in accelerating access without compromising rigorous science. So tell us a bit more about this executive order, what it really means? What will you do differently or what can you do differently now because of it?

38:57Yeah, well, first, we welcome the executive order because it's really grounded in two fundamental principles. First, that patients urgently need new treatments and they've waited too long for that. But second, that it must be informed by rigorous science. So the focus on FDA approved medicines, doing the studies to the right level and so on. So we welcome the executive order. What it talked to was some potential regulatory flexibility around the FDA moving perhaps faster. And there's talk of certain vouchers being given out. We don't yet know who may receive those, but that's one element. And second, these medicines today are illegal.

39:37So until and unless they receive approval, they are not able to be made available. There is the DEA needs to change that status and executive order accelerates the process of that. So taken together, this is really about first those medicines like ours that are very late in development, potentially getting to patients significantly sooner, but it also encompasses another and other executive, another, other actions that potentially make it easier to research these medicines, which today is complicated and takes time and a lot of money because of some of the restrictions that have been around them, but also directs a number of agencies within the government to work together to really build the implementation, the infrastructure, and to accelerate the potential for psychedelics to get to patients across the spectrum of serious mental illnesses.

40:31And I would assume... So together we...

40:33Carol Massar:Yeah, no, forgive me, forgive me. No, I was just thinking, though, as you were saying that, you know, expediting everything, And that includes, I was thinking, Tim, coverage by health care as well. Well, that's certainly, yeah. Part of this, a big part of it. Well, so answer that and go there. Go there for us. What it means for this to be expedited, what the next step of actually getting this covered by insurance, at least here in the United States, would be. What's the outlook for that? So assuming an FDA approval, so if we are approved for COM 360, then we believe that data we've generated showing the efficacy and the safety.

41:09This is well-tolerated, generally safe. First, we need that to get an FDA approval. And then we will take that data, that profile, and work with commercial insurers, government pairs as well. And we're confident in the strength of that data, particularly relative to anything that's available for patients with this chronic refractory depression today. And we're confident in delivering that value through insurance to patients. Okay. We'll have to wait on that one. You know, there are a lot of steps before that, that actually happens, but before you get there, and because you are a publicly traded company, there are a lot of companies that are working on using psychedelics to treat treatment resistant depression.

41:53Where do you think about differentiation and like, what's your biggest competitive advantage to other companies that are working on this? First, we are significantly ahead of other companies. So I think it's important to say that we have the potential, if approved, to be the first in it. But again, psychedelics are very different. So there are a number of dimensions of difference around the different modalities. There is the nature of the experience. Psilocybin is an experience. Typically, a patient will be wearing eye shades with music playing in a relaxed environment exactly as we have used in our clinical trials, it's a very inner directed experience.

42:34It's an experience where the patient is working through the acute psychedelic experience, allows them to work through their sense of self, their sense of self in relation to their symptoms. That's a very different experience from some other psychedelics. And so those differences in terms of the experience, the nature of the subjective experience, as well as perhaps duration and so on, those will actually all become apparent over time. We believe, again, with the rapidity, durability we've already shown, and nobody else has come close to doing the size of studies we've done yet to come to that, with that and the nature of the experience itself with psilocybin, that indeed will be differentiated and will be compelling both to providers and to patients.

43:19Carol Massar:So I am curious too, though, you know, we were thinking about this, Kamir, when we were thinking about talking with you, that if you go back to 2024, you did see the FDA reject an MDMA-assisted therapy for PTSD from Lycos Therapeutics. They were a private company, I should point out. And they cited the quality of research and questions over the clinical trial design. Is there anything Compass is doing differently to ensure it won't meet the same fate? or do we need to be worried at all? We have conducted a very different program. So the Lycos program was designed many years ago in a different era.

43:58Compass has conducted this really to the highest standards of rigor. First in our two late-stage studies, we actually have over 800 patients represented. The studies themselves are very well aligned with the FDA's own draft guidance from three years ago for how they want to see studies designed. We have been incredibly rigorous about collecting all safety data, all elements of the subjective experience and how they impact on it. And also, we are not providing therapy alongside the drug. This is we're providing the medicine with support, with patient safety, absolutely the heart of it. So it's really a very, very different model from the MDA model, not only in terms of what it actually means for the patient, but also in the way that we have conducted the trials.

44:45So we are confident that based on the data we're seeing, based on the robustness of that data, we will have a very different experience with the regulatory process. Kabir, on that, and only 20, 30 seconds left on this to follow on Carol's question, what are the remaining clinical risks for psilocybin therapy in treatment-resistant depression? We will work with the agency. We are already working with the agency. We believe strongly that the data we've shown on efficacy and safety is compelling, but ultimately it is the FDA's decision as to whether to approve. We are excited about what the EO means for us.

45:21We're excited about the path forward and getting this to patients as soon as possible.

45:25Carol Massar:Bottom line, it's a big change, big move, that executive order. It is. Absolutely. It's a great move for the field. All right. Kabir, always appreciate the time that you've given us over the months, over the years, and really appreciate you coming on, especially as this is certainly a sector we're watching in today's trade. Kabir Nath, CEO of Compass Pathways, joining us here. And again, as we said, that stock is on a tear. We saw it. Let me just pull it up. It was up more than 50 % earlier. Yeah. And right now up 43%. Yeah. So quite a bump to the upside. And the stock is now positive for the year, which is interesting because it was under pressure.

46:02Carol Massar:It's now up about 38 % year to date. This is the Bloomberg Business Week Daily Podcast. Available on Apple, Spotify, and anywhere else you get your podcasts. Listen live weekday afternoons from 2 to 5 p.m. Eastern on Bloomberg.com, the iHeartRadio app, TuneIn, and the Bloomberg Business app. You can also watch us live every weekday on YouTube and always on the Bloomberg Terminal.

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US President Donald Trump said he’s not likely to extend the two-week ceasefire with Iran, increasing the urgency for negotiators to conclude a deal to end the war.

Trump said in a Monday phone interview that the truce, which he announced April 7, expires on “Wednesday evening Washington time” — possibly buying more time for negotiations. But the president also said it’s “highly unlikely that I’d extend it” if no deal is reached before then.

“I’m not going to be rushed into making a bad deal. We’ve got all the time in the world,” the president said.In the interview, Trump reiterated that the Strait of Hormuz would stay blockaded for now, saying “the Iranians desperately want it opened. I’m not opening it until a deal is signed.” Iran previously said it would open the critical waterway for energy supplies to international shipping, but reversed that decision in light of Trump’s refusal to follow suit.

Details about the next negotiating session, expected to take place in Pakistan, started to came into focus on Monday. Iran is also sending a team, according to people familiar with the plans who declined to be identified, although it is not clear who would lead the delegation. Earlier, Tehran said it was hesitant to participate in further peace talks with the US.
Today's show features:

  • Jeff Mason, Bloomberg News Washington and White Correspondent on his conversation with President Trump & Stuart Paul, Bloomberg Economics US and Canada Economist to Preview Kevin Warsh Hearing
  • Rich Weiss, American Century Investments Chief Investment Officer of Multi-Asset Strategies
  • Dina Bass, Bloomberg News AI Infrastructure Reporter on Google Bets on New AI Chips
  • Kabir Nath, CEO at Compass Pathways, on President Trump Signs EO to Ease Psychedelic-tied Therapies Access

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