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Daily Tech News Show

5 Jun 2026 · 35m · 12 chapters

Episode artwork

How Does Gurman Get All Those WWDC Leaks? - DTNS 5284

In short

DTNS 5284 focuses on how Bloomberg’s Mark Gurman gets Apple WWDC leaks, plus a roundup of major tech news and an interview about a drug to regrow teeth.

Guest backgrounds

The episode’s interview guest is Dr. Nikki Ackermans, a science correspondent who discusses teeth biology and related research. Other hosts (Jason Howell, Jen Cutter, etc.) discuss Gurman’s reporting methods.

Key claims

Gurman’s high WWDC “hit rate” likely comes from longstanding, informal access across Apple’s large employee base, plus people leaving companies and possibly internal review-style relationships (not necessarily paid). Apple may tolerate leaks to stay in the news cycle ahead of WWDC.

Notable examples

Leaked expectations include OS 27 across Apple platforms, an overhauled Siri, and a revamped AI strategy with deeper system integrations. Interview: an anti-USAG1 antibody drug (developed by Dr. Takashi’s team) aims to regrow teeth; Phase 1 started in 2024, with Phase 2 targeting children with congenital tooth absence and Phase 3 planned for 2029.

Written by AI. May contain mistakes.

Chapters

0:03

Mark Gurman's Apple WWDC Leaks

Explore how Mark Gurman gathers information on Apple's WWDC.

“It's called Chat Concierge and it's simplifying car shopping.”
2:57

Mark Gurman's Apple WWDC Leaks

Explore how Mark Gurman gathers information on Apple's WWDC.

“We're going to start with what you need to know with a big story.”
4:32

The Mechanics of Tech Journalism

Discussion on the relationships and sources behind tech leaks.

“I wonder about these things when they happen because it's like here it is Friday ahead of the event.”
8:06

Gurman's Insights on Apple’s Future

Examine the implications of Gurman's leaks for Apple's AI and product strategies.

“you know that this is not coming from just one person.”
14:50

Gurman's Insights on Apple’s Future

Examine the implications of Gurman's leaks for Apple's AI and product strategies.

“What if you had a room where no one interrupts?”
15:26

OpenAI's Memory Upgrade

Discussing OpenAI's new memory architecture for ChatGPT and its implications.

“OpenAI rolled out an upgrade to ChatGPT's memory system that builds on its dreaming architecture.”
19:02

Meta's Facial Recognition Feature

Exploring Meta's unreleased facial recognition technology and privacy concerns.

“That's the name of the feature, apparently.”
20:54

Ferrari's Luxury Laptop

A look at Ferrari's collaboration with HP on a high-end laptop design.

“Ferrari is partnering with HP on a new high-end laptop called the HP Scuderia Ferrari AI PC.”
24:22

Tech Headlines Overview

Rounding up various tech headlines including Valve, vaccines, and AI developments.

“It's called Chat Concierge and it's simplifying car shopping.”
28:00

Regrowing Teeth: The Science Behind It

Learn about the innovative research into regrowing human teeth through protein inhibition.

“And we said if this ever goes to trials, we would follow up.”
Show all 12 chapters
31:40

The Future of Tooth Growth Trials

Explore current clinical trials and the potential for new tooth growth therapies.

“and sooner than you'd think I feel like for these things it's like yeah in in you know 100 years We'll figure this out.”
35:39

Personal Experiences with Dental Issues

The hosts share personal dental experiences and considerations for future treatments.

“And I'm not a dentist, but I think you'd have to like wear braces while it's growing so the other teeth don't move back and fill that spot.”
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Transcript

Automatic transcript. May contain errors.

0:00This episode is brought to you by Capital One. Capital One's tech team isn't just talking about multi-agentic AI. They already deployed one. It's called Chat Concierge and it's simplifying car shopping. Using self-reflection and layered reasoning with live API checks, it doesn't just help buyers find a car they love. It helps schedule a test drive, get pre-approved for financing, and estimate trade in value. Advanced, intuitive, and deployed. That's how they stack. That's technology at Capital One. Hey, it's Paige from Giggly Squad, and I want to let you know that if you want the newest and hottest beauty products, you have to go to Sephora.

0:36I'm obsessed with the One Size Liquid Blotting Paper Spray. It's the first of its kind blotting spray that mattifies for up to eight hours. It's unreal. There's also the Summer Friday Shade Drops SPF 50, which basically lives in my bag at this point. Oh, and the Kayali Eden Plush Pear smells so good. It's sweet, warm, and addictive. like people literally stop me and ask what perfume I'm wearing, which you know I love. So if you want the makeup, skincare, hair, and fragrance products everyone's about to be obsessed with, shop only at Sephora. Shipping, billing, admin, payroll, marketing. You're managing all the things.

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2:34Hello, everybody. This is the Daily Tech News for Friday, June 5th, 2026. We tell you what you need to know, give you the important context, and help each other understand. Today, Dr. Nikki tells us how we can regrow our teeth. I'm so excited to hear about that. And Mark Gurman knows all about WWDC, but the big question is how does he know all that? How does he know all this stuff? We just, we got to ask the question. I'm Jason Howell. I'm Jen Cutter. We're going to start with what you need to know with a big story.

3:08Oh yes, everybody today's talking about Bloomberg's Mark Gurman's piece of what to expect at Apple's WWDC keynote happens on Monday. Gurman does what he does well. We talk about it on this show many times, mentioning his name because he's so prolific. He spills the beans on what Apple has in store, always ahead of any sort of official announcement. He just has some really great sources. And sure, we could spend time talking about what he's sharing. And we'll probably mention a little bit of that. But you're going to want to make sure that you check out Monday's coverage here on the show of the actual announcements.

3:46Tom is going to talk with Nika Montford of Snow Boss. Is it Snow BOS or Snow Boss? My apologies on the show. And they're going to talk about the announcements, the actual announcements, not the leaky stuff. So I'm less interested in the details from the article. But like I said, we'll probably touch on that at the end. I'm more interested in talking with you, Jen, about kind of the machinery around how reports like this happen, Especially when you talk about a company like Apple, arguably one of the most resourced companies, outfits, whatever you want to call them, that could possibly shield themselves from these kind of leaks that just kind of reveal everything.

4:32And I don't know. I wonder about these things when they happen because it's like here it is Friday ahead of the event. Supposedly we know everything. I'm sure Apple has some things that it's holding in its pocket that even Gurman doesn't have. But it makes you wonder, like, how does a person in Gurman's place get access to this stuff? Have you considered that? Yeah. I know from my previous work, especially now, you kind of have an advantage when it's a company as big as Apple. Because Apple has, boy howdy, a lot of employees. And a lot of employees at various tiers. And when you're working in a field, it is unavoidable.

5:07You're going to meet people who work for various companies. You're going to make friendships when you see the same people over and over again. So it's not even like intentionally cultivating sources. You're not like paying people under the table. At least you shouldn't be paying people under the table to get leaks and stuff. Gosh, who knows? And then you have people exiting companies, which happens commonly, like not even for nefarious reasons. You just have people who are no longer at Apple, who move to Google or anything and just decide, hey, here's what I know. Here's my signal. Here's where this is going.

5:39and for something like this too you might also have an unofficial relationship with people higher up where things get sent to you as a test like for video games a lot of companies will do internal reviews where they will pay someone like me to play a game review it internally and give my true hardcore opinion because I don't have to couch it for a casual audience so that they are prepared for any feedback that an audience has so they can get their talking points ready. In some cases, it's early enough that they can fix things that might raise some hackles if they come out. Yeah. Well, and I think that's probably a big part of this, right?

6:23Now, granted, we're kind of guessing here, although I've heard over the years that there are official arrangements, relationships, whatever, that companies can and have struck with certain reporters to make sure that things are leaked in advance at just the right time to get ahead of bad news or to signal to them kind of what to expect. And I'm not saying with any sort of certainty that that happens with Gurman, but it is really interesting that Mark Gurman is so well-sourced. He's got so many sources dotted throughout Apple's internal structure. And not just like the one-offs like, oh, I just left.

7:01Here's some dirt and move on with my life. He's got people that are continuously in there, one has to imagine, because he's so consistent with coverage like this. And it really makes you question like, okay, if that's the case, A, what do those people have, what are they incentivized by? And B, does Apple actually get something out of something like this? And I think you bring up a really good point. Apple's in a very interesting position right now when it comes to kind of its AI strategy. This is the thing, this is the microscope that seems to be on Apple at this moment. Are they behind? Are they going to, you know, renovate Siri to a point to where it seems like they're catching up?

7:43Or are they still playing catch up? And advanced looks into what they're about to announce a couple of days from now gives Apple a little bit of a head start to understand like, OK, people, if they know enough of these details in advance, we start to see how they're reacting to them, what public sentiment is, what is the pushback. And it gives them some time to kind of prepare for what's about to happen. Yeah. Gurbin has a very enviable hit rate. Yes. Dude is on it. you know that this is not coming from just one person. You know that Gurman has done the work, has verified this. And even when he has to come back and say, hey, that thing I said six months ago, it's changed now and they're pushing it back again.

8:25We all take that pretty much at face value because of his amazing hit rate. So that is a huge positive for him. And it is a positive for Apple because it's not like some third-party person who only leaks something once every two years where they found like, hey, we found all of the pictures of the phone. In gaming, a lot of things get leaked in South Korea because you have to file for marks so early. So I know that like for Paradox, a game that I'm looking for, like Lego Skylines is coming in. I'm like, there's a Lego Skylines? That's awesome. And I know that just because of, you know, standard filing in South Korea.

9:02Gurman does not have that to the same extent. And yeah, it's just people. It's good old fashioned journalism and it's good old fashioned. I have contacts. Yeah. And I mean, he is a fantastic journalist. He knows how to handle himself when it comes to these leaks, you know, and to kind of cover his tracks and the source of tracks. Yeah, he knows the line. Yeah, he really does. He really does. That's what makes him so respectable here. But it is interesting, like how much of that relationship with Apple, you know, is done in an explicit sense. Like, is there, you know, direct involvement? Is this all done kind of behind the scenes?

9:37Oh, Apple has no clue. Is Apple actually kind of part of this, whether clandestinely or more outwardly? And if that's the case, is Gurman on the hook to only say the things that he's allowed versus not? I mean, it's a lot of questions. I'm not I'm certainly not casting any doubt. I love Gurman's work. And I just I just find this fast this facet of tech journalism just fascinating because I've been dealing with it for the last 20 years in the smartphone world. Android leaks, Apple leaks and everything. And, you know, they just they continue on. I have to ask, like, you know, a question like, OK, what is the source of this?

10:18How does that work? If it was like an official partnership kind of thing, ethically, you'd kind of want to have to disclose that, which is why I think this is just old fashioned journalism. This has been going on too long. It would be a huge scandal if this was like official, official. But like Apple looking the other way is different. That's like you don't have to take responsibility for that. Yeah, that's what you nailed it. Yeah. And that's what I actually believe is to a certain degree, Apple might not want certain things out there. But it also realizes that, oh, you know what? This actually gets people, it gives them extended attention, extended coverage, you know, when things like this happen in advance.

10:54Oh, yeah. It keeps them in the cycle every Monday. Every Monday, you know, Apple's going to be in the news. And if you know Apple started taking a swing at him, that's going to Streisand affect it to the stratosphere. Totally. Yeah, yeah. Good point. So real quick before we move on, what exactly did Gurman share? I feel like what he shared mostly was stuff that we've already been talking about. So I think it's just more like, okay, all this stuff that you've been expecting from previous leaks is definitely happening. Of course, OS 27 across all of its surfaces, an overhauled Siri as the centerpiece, a newly revitalized AI strategy, though it's going to be labeled beta, apparently, according to German sources.

11:35More conversational, deep integration into system apps, integrations across various models. So the ability to kind of choose different models for different things. And then you got your AI integrations into photos, camera, system-wide writing tools, shortcuts, automation building, wallet, bill splitting features. There's a number of things in there. I don't want to give you the entire list because, I mean, after all, it is still ahead of the event. And the event is where the actual stuff happens. So you've got to check out Monday's episode of Daily Tech News Show where it will all be spelled out in an official sense.

12:14TGNS is made possible by you, the listener. Yes, you. Thanks to AB Puppy, Dale Mulcahy, Matt Zaglin, and Shahar Gevall. Thank you, thank you, thank you, thank you. We appreciate each and every one of you. Yes, indeed.

12:42but real-time cash flow? Wow. Invoices that chase themselves? Even better. Books that automate? That's a big one. And I can keep track from my phone while I get the job done. No spreadsheet in sight. What a life. Do right by yourself and your business and search Xero for your free trial. Conditions apply. This episode is brought to you by Capital One. Capital One's tech team isn't just talking about multi-agentic AI. They already deployed one. It's called Chat Concierge and it's simplifying car shopping. Using self-reflection and layered reasoning with live API checks, it doesn't just help buyers find a car they love.

13:21It helps schedule a test drive, get pre-approved for financing, and estimate trade-in value. Advanced, intuitive, and deployed. That's how they stack. That's technology at Capital One. Hey, it's Paige from Giggly Squad and I want to let you know that if you want the newest and hottest beauty products you have to go to sephora i'm obsessed with the one size liquid blotting paper spray it's the first of its kind blotting spray that mattifies for up to eight hours it's unreal there's also the summer friday shade drops spf 50 which basically lives in my bag at this point oh and the k ali eden plush pear smells so good it's sweet warm and addictive like people literally stop me and ask what perfume i'm wearing which you know i love so if you want the makeup skincare, hair, and fragrance products everyone's about to be obsessed with.

14:09Shop only at Sephora. Parles-tu français? Hablas espagnol? Parli italiano? If you've used Babbel, you would. Babbel's conversation-based technique teaches you useful words and phrases to get you speaking quickly about the things you actually talk about in the real world. With lessons handcrafted by over 200 language experts and voiced by real native speakers, Babbel is like having a private tutor in your pocket. Start speaking with Babbel today. Get up to 55 % off your Babbel subscription right now at babbel.com slash acast. Spelled B-A-B-B-E-L dot com slash acast. Rules and restrictions may apply.

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15:23All right, there's plenty more that we need to know today, so let's get right to the briefs. OpenAI rolled out an upgrade to ChatGPT's memory system that builds on its dreaming architecture. This is meant to make long-term personalization more accurate and much more visible to users, including those on the free tier. OpenAI says the new memory architecture will be much more compute efficient and, quote, significantly more effective at remembering key personal interactions and details. The new system involved a new memory summary system that the LLM will write to as users interact with the model.

16:02Users can take a look at the summary by request and can add or update any information listed there. Users can also tell ChatGPT what it should know or remember to have that information stored there for future reference so you do it once you're kind of ready to go. The changes will begin to roll out to paid users in the U.S. now, free users coming soon, and other countries it'll spread to in the next couple of weeks. Yeah, memory in these LLMs has just continued to be a real, I don't know what the right word is, unlock. Expensive. Certainly, but really powerful when done right. Now, there's the people on the side that are like, oh, you know, I don't want it to know so much about me, particularly, so they're going to feel a little weird about certain details being stored and used, within your chat experience.

16:50But what it really reminds me of, big surprise, because I've mentioned it many times on the show, I've been working so deeply with Claude and Claude Cowork recently. And if you're working in Cowork, you have this architecture inside of there as you get deeper with it, like Claude MD files, Memory MD files for Markdown files. And it's very similar to this. It's like a memory architecture that as you work with it, it stores little pieces of things it learns about you in this Markdown file. and then is able to call those later. And this kind of feels like that, of course, happening in the cloud, not on your machine, happening for free users.

17:26So it's a really powerful kind of development for these systems and makes it a lot more, yeah, just beneficial when you use them. Have you gone into the Markdown files to edit, remove, add anything at this point? Oh, yeah, absolutely. I've been going down the wormhole, the rabbit hole, whatever hole it is. the past couple of months on Claude in really learning and understanding that architecture and how those MD files work. You know, it's all text. It's just text with a few, you know, kind of accoutrements that make it AI readable or LLM friendly, let's say. But it's really easy to understand and to make changes to.

18:09It's just text, you know. So would something like this make you like switch or integrate it a bit more instead of just Claude? Well, I'm not sure because I kind of like having with Cloud Cowork, I like having a space on my hard drive that has the whole architecture. I've created this entire file directory system. I've gotten really nerdy with it, let me be honest. And something like what we're talking about here with ChatGPT kind of happens more in the cloud. And right now I'm more on my device. So it might not explicitly, but I do use ChatGPT for certain things. This will undoubtedly help and inform those interactions going forward.

18:50So, you know, it's just like one of those features that's going to make it a lot more personal, I think. And you'll probably notice it over time. So, interesting stuff. Wired reported finding references to an unreleased facial recognition feature inside the Meta AI app called Name Tag. That's the name of the feature, apparently. It is not running actively. It's not currently sending any biometric data to Meta, so that's confirmed. But the code does describe a system that captures faces through glasses like Meta's Ray-Bans, as one example, and then alerts the wearer later when it recognizes someone they've previously recorded with the glasses.

19:31It places them inside this connections section that keeps track of people that the wearer has met. Meta spokesperson Ryan Daniels confirmed to Engadget that the company continues to explore these features, reaffirmed that nothing has shipped, no final decisions have been made. He also offered, kind of unprompted, that Meta is, quote, not building a central database. I just want to say this randomly. We're not building a central database. And that any sort of launch would be thoughtful and transparent if and when they choose to do something like that. That's not going to stop anyone who's really privacy conscious from saying, hey, well, then don't do that.

20:10But there it is. Yeah. The reaction from my InfoSec friends was, of course they did. Of course it's in there already. Yeah. It doesn't feel like a thoughtful and transparent thing when Wired had to be like, hey, did you know this was happening? Right. I also came across a term that I hadn't heard before. I mean, I've heard spyware before, but I hadn't heard it in terms of this, spy, W-E-A-R. This is spyware, as in like wearable spy. I thought that was interesting. That's going to catch on. That is definitely going to catch on. Definitely, definitely. Well, we will definitely be covering any thoughtful and transparent rollouts, should that happen in the near or far future.

20:52But we are going to shift gears, literally, because Ferrari is partnering with HP, which is not a sentence I ever thought I would say. Ferrari is partnering with HP on a new high-end laptop called the HP Scuderia Ferrari AI PC. Real catchy. It's a$5 ,600 limited edition 14-inch laptop that's built as a design-first machine, as you might imagine, because, you know, their cars are pretty. There are only 4 ,999 units planned worldwide, so very limited edition run. It has a Rosso Magma-style red finish inspired by the Daytona SP3, a carbon fiber underside, and a transparent engine bay with the processor and cooling system protected by Gorilla Glass.

21:42The trackpad is nearly invisible, and each key has RGB lighting shining through Ferrari's typeface. On the inside, which is important, there is an Intel Core Ultra X7 with integrated ARC Intel graphics, 64 gigs of RAM, and a 1TB SSD. And it has a 3K OLED touchscreen. The laptop goes on sale June 12th in select markets, including US, UK, Italy, and Japan. And go look at pictures. It's so pretty. It is pretty. We want more like the old school Macs and the old school Game Boys. We could get clear plastic on stuff. The clear Gorilla Glass section looks awesome. It looks so good. Yeah, I love through the inside a little bit and everything.

22:25But, I mean, this is really all about design, less so about performance. Although I'm not entirely, like, personally familiar with Intel Core Ultra X7. But the fact that it's an integrated graphics instead of, you know, kind of on its own, like a dedicated GPU. For a, you know,$5 ,600 laptop, I'm just like, really? You couldn't go that extra mile. Yeah, because Intel Arc is pretty good and getting better. But yeah, you wouldn't put Ferrari with the integrated thing. And I'm thinking, does this bring the cost down? Also, what does carbon fiber cost these days? Because that probably isn't cheap either.

23:02No, probably not. But it's a pretty machine. I'll give it that. It's so pretty. Look at pictures. Honestly, it's worth it. Cheaper than$5 ,600. It is graduation season. And we would like to congratulate our very own graduate, Live With It. That's the show that reviews products that we actually live with and use. And it is becoming its own show with its own YouTube channel and its own Patreon. To support Live With It as it spreads its wings and grows as an independent thing, please head to patreon.com slash livewithit and keep checking out. They're pushing out banger episodes every single week.

23:42Indeed.

23:48Business is booming, but you know what really helped? Zero, the accounting platform for small businesses. I used to think unpaid bills were just part of it. Ugh. But batch payments? Wow. Automated accounts payable? Even better. All in one place. That's a big one. And I can keep track from my phone while I get the job done. No bills in sight. What a life. Do right by yourself and your business. and search XERO for your free trial. Conditions apply. This episode is brought to you by Capital One. Capital One's tech team isn't just talking about multi-agentic AI. They already deployed one. It's called Chat Concierge and it's simplifying car shopping.

24:30Using self-reflection and layered reasoning with live API checks, it doesn't just help buyers find a car they love. It helps schedule a test drive, get pre-approved for financing and estimate trade-in value. advanced, intuitive, and deployed. That's how they stack. That's technology at Capital One. All right, we have a few headlines to rattle through, and then we got an interview. So let's dive right in. Valve says its Steam Machine and Steam Frame will launch this summer. I don't know how, but they're saying this summer. So we still have like no idea when specifically or for how much, but Valve did share that they will be included in the verified program for games compatibility clarity.

25:15And the Steam store just got a refresh. So look for it and pray and hope that it is semi-affordable. We'll see. Maybe not as expensive as the Ferrari laptop, but yeah, we'll see. Cambridge researchers ran the first human trial of a universal super antigen vaccine designed at its core by an AI model that safely triggered protective immune responses against SARS-CoV-2, SARS, and Sarbeco coronaviruses. Interesting. Fingers crossed for that, for high-risk people. Cloudflare CEO Matthew Prince says that agentic bots now account for 57.5 of global HTTP requests versus 42.5 for humans, something he had previously predicted would happen in 2027.

26:04Wow. Okay. So the percentage has flip-flopped. There we go. Thanks to RWNash and the subreddit, Brave launched Brave Origin. It's a$60 one-time stripped-down version of its browser. It keeps Brave Shield, but then disables a bunch of monetization hooks like rewards, wallet, Leo AI, news, talk, VPN promos, and sponsored images. So, you know, you might like that. Go for it. Anthropic is calling for a coordinated global slowdown of frontier AI, citing internal data that suggests models are getting closer to, quote, recursive self-improvement that could surpass safety efforts and, it says, reshape society dramatically.

26:46I swear with these companies, it's like out of one mouth, they're saying, hey, check out how fast and how capable these things are. And on the other side of their mouth, they're like, but slow down. I don't understand, Anthropic. I don't get it. Fitbit Air users who want a watch on their screenless band are now threading analog and automatic watches onto the Air's strap. So they hide the tracker under the wrist and then the watch face is on top, to which I say, nerds! But it's okay, I would totally do that too. Hey, best of both worlds, ready to go. Metal launched the Creator Assistant, a conversational AI in Facebook's creator dashboard that explains why posts and reels perform, along with suggestions from trends and creator data that might get them to perform better in the future, which sounds pretty handy.

27:39Very handy, if it works. Those are the essentials for today. Let's dive a little deeper. Human trials, actual human trials, have begun for a drug that could let adults regrow teeth. Dr. Nicky tells us more. So we have talked in the past about a drug that will let you regrow your teeth. And we said if this ever goes to trials, we would follow up. And so we are following up. Thank you, Dr. Nikki, for holding our feet or our teeth to the fire. Sure. You're welcome. So give us the background for those who may have missed the earlier stories about this. Sure. So Dr. Takashi of Osaka in Japan has been working on the problem of regrowing teeth for the last three decades.

28:28I like this because it's the scientist who's like, I'm going to fix this problem, and then is very close to fixing this problem. So that doesn't always happen. Right, right. But back in 2007, his team discovered a mouse model that was mutated and it had way more teeth than usual. And they worked on this for a long time to try and figure out what this is and if you can, you know, if it's going to be helpful for the problem for humans. And they ended up finding out that this mouse lacked a protein that's called USAG1. And it's a little bit counterintuitive, but this protein basically suppresses the development of tooth buds.

29:05So you have kind of embryologically a bunch of tooth buds in your, well, in a mouse, in the mouth that unless something is stopping them will grow teeth. So we didn't know this until they figured this out. But once they kind of inhibited this protein in this mutant model, these mice could then just grow a bunch of extra teeth that were fully functional. So that's kind of the principle behind it. Yeah, it does sound backwards to think like there's a protein that stops your teeth from growing versus one that encourages it from growing. how does this work biologically so as you probably know we have a set of baby teeth that eventually fall out around adolescence and then our permanent adult teeth grow and then they stay there and then if those fall out tough luck we've got no more teeth after that except for this group found out that technically we do have a third set of teeth buds that are dormant inside our mouths so that's very lucky for their application because it wouldn't work without this.

30:04So they never grow into a next set of teeth because they're being stopped by this USAG1 protein. So the idea is if you administer an anti-USAG1 drug, you can inhibit the inhibition, which is a double negative, which means your teeth can grow. So it wouldn't be like you inhibit USAG1 and then you're just nonstop teeth falling out of your mouth like some kind of nightmare you have to have the point you have to have the buds but we do we're not turning into sharks but those buds are theirs and you can do it locally so it wouldn't be like all of them at once but if you have one tooth that fell out you could potentially target with an injection like target this one area just inhibited in the area you need it and why do we know why we have the third set of buds i mean if you i haven't looked this up but if you ask me from an evolutionary standpoint a lot of animals before us do and so it's kind of an anomaly that we don't have an extra set so it's kind of yeah it's kind of a leftover um and that actually addresses like why there's multiple animal models which we can get into as well yeah so this third set of buds is for you you might say i don't understand the joke that's a Budweiser old very oh yeah you know they should really jump on this we should get that sponsorship all right let's forget about that uh is this ready for me can I can I like I've got my full set of teeth but who knows for how long if we could pull them out and put right get new ones will I be able to say like yes just grow me a new tooth so potentially soon and sooner than you'd think I feel like for these things it's like yeah in in you know 100 years We'll figure this out.

31:51But it's like maybe five years from now and actually less. So over the last decade, this team has been developing specifically this drug that is an antibody that so suppresses the function of the USAG1 protein. So it turns it off and allows this tooth bud to grow and proliferate. So they tested it in mice and in ferrets. And none of these had serious side effects. And they grew like perfectly healthy teeth. And I think it's really interesting that they had. So the reason they had these two different models is because mice have ever-growing teeth. So if they don't wear them down, they just grow forever.

32:26Kind of like if you think about how beavers have these two front teeth that are really long. If they don't chew on them, they just keep growing and can grow into their mouth. So they don't have the same kinds of teeth that we do, but ferrets do. And the trial was also successful in ferrets. So that's like a step closer to kind of human tooth structure, right? So that was really promising. And once they got those results, they started the phase one human trial, which started in 2024 and ran for a year. So phase one is usually just like a safety trial on. And in this case, they did it on adult men who are missing one molar.

33:03And really, the goal is just to make sure there's no serious side effects happening. Now, we haven't heard back whether this was successful, but the plan right now is to move on to phase two trials. and they're targeting specifically children with a congenital disease where you just never develop teeth at all so hopefully they can kickstart this this tooth growth um and this will run through 2027 so i'm assuming that's running right now but it hasn't been revealed yet and then after that if that one's successful phase three which is usually a large-scale trial uh is planned to start in 2029 and potentially a drug would be available in 2030 so if your teeth fall out in the next four years telling you might just in time for my teeth to start falling out when I turn 60.

33:49So that's great. Yeah. And this has really wide applications. Now, of course, they're targeting these kids with the congenital disease, but about 7 % of people in their 20s in the world has lost one or multiple teeth. And then once you, of course, rise in age, about 20 % of people over 60 are missing teeth.

34:10So potentially replacing implants or even dentures, especially in kids. They have to get different denture sizes as their mouth goes. So huge applications here. Really exciting. This is something I've started thinking about is like my teeth are in very good shape, but, you know, they're old. And I'm always thinking, well, implants are probably the better way to go because then you don't have to take dentures in and out. But this would be much better, I would think. Would you do it? Okay, so here's the first thing I thought. how much does that hurt though? Like surely, I've had braces. I've felt what it feels like to move your teeth, like growing too much.

34:49So I would probably still do it. I'm also like, what if it grows backwards? What if it, you know, are the molecular signals still there to tell it to grow in the right direction? I mean, I'd rather have a backwards tooth. Well, that's why they're doing the trials, right? To make sure, but yeah. I'd rather have a backwards tooth than not a tooth, I guess I suppose like I would probably definitely rather do that than probably definitely yeah honestly I have a cap and I don't like it I can feel you know it hurts when I eat ice cream so I'd rather have my own tooth but then that's the last one there's no more buds after yeah that's true like you got to take care of that one because yeah but still another one well that's a really interesting question too like I have I have fillings that are really old would I rather like Like if the filling needs to be replaced, which I've had that happen once, would I rather just be like, just take it out and grow me a needle.

35:40And I'm not a dentist, but I think you'd have to like wear braces while it's growing so the other teeth don't move back and fill that spot. But here's the other thing I'm thinking about. So teeth evolutionarily come from skin. I don't know if you know about this. So you know how shark skin is like very sandpapery? Yeah. So those are, it's actually like formed with denticles that are tiny mini teeth. And what happened evolutionarily is like the region around the mouth got bigger and bigger denticles. And that's why sharks have this kind of like moving carpet style tooth replacement. It's just like modified skin pieces.

36:14Yeah. Interesting. And so we have a very, very far away developed version of that, but we only have three. And so I'm like, maybe they can activate even more and we can have shark teeth. Right. That would be the next step. is to become shark people. You'd probably have to inject it really early on, like as an embryo, but you know, I'm thinking ahead. Right, no, I appreciate that. This could time out very well for me. I'm very pleased to hear about this. Yeah, you're like in the right time phase for this. Dr. Nikki, thank you as always for helping us wrap our heads around this sort of thing. If people wanna follow more of what you do, where should they go?

36:49Yeah, you can find more about teeth and sharks and all these other things over at nicoleackermans.com and I have the same handle on Blue Sky. So let me know if you would get an injection to grow new teeth. Fantastic. Thanks, Dr. Nikki. All righty. I'm not sure that I would, but I have to give a standing clap for Tom's This Buds for you. I appreciated that, Tom. I appreciate it very much. So you know that commercial. All right. I would absolutely do it. I would 100 % do this. Like Dr. Nikki, I did have braces. Yeah, me too. The day after I got them off in gym class, we were playing lacrosse without helmets.

37:29And I protected the ball and not my face. So that's why, like, my top teeth survived. My bottom teeth got all messed up. And it's been a problem. And, like, yes, I will deal with the pain. Let's go. Put the braces on if we need it. That would be incredible. The day after you got them. Oh, that sucks. That sucks so bad. Oh, my parents. Oh, when I had to tell them that news. But, like, they had to see me all messed up. I didn't break my jawbone, so I was pretty happy about that. But yeah, sometimes athletes aren't smart is all I have to say, myself included. I mean, who would have known the day after you got your stinking braces off?

38:03That's crazy. We end every episode of DTNS with some shared perspectives. Today, Ben from Virginia reports on using Amazon's improved assistant to help him search on the Amazon website. Ben writes,

38:44and got results that included things like Jung Chian Mei Corp. So that part failed, but that seemed like typical LLM uses. I don't see myself using this for other touted uses like agentic actions or deep AI integration, but hopefully it can help filter a bit better. Thanks and love the show, Ben from Virginia. I mean, with all these things, they never work perfectly all the time. So I guess, yeah, sometimes you're going to get what you're looking for and sometimes you aren't. I seem like, oh, Ben, I have one. And I actually have one of those because I bought it when it was so old. Well, I bought it.

39:15My parents bought it. And I still keep it around because sometimes for laptops, you just, yeah, it's just read-only. But sometimes I find my old CDs from high school and I want to save them. Heck, yeah. I've got a whole, I've got spindles full that I, you know, still, I have a Mac Pro from like 2007 that I still have primarily because of that. Like I still need a thing to hold them on. Yeah. And it's too big. I don't know what to do with it. Yeah, exactly. Big and heavy. Like, oh, interesting. That's how I formatted my Word documents back then. Yeah, interesting. Thank you, Ben, for writing it.

39:49As was the style at the time. Do you have styles at the time that you want to share with us? If you've got anything you're thinking about, any insight to a story, please share it with us at feedback at dailytechnewsshow.com. Yeah, big thank you to Ben for contributing to today's show. Thank you out there in podcast land for being along for Daily Tech News Show. You can keep us in business by becoming a patron. Go to patreon.com slash DTNS.

40:19All right, this week's episodes of Daily Tech News Show were created by the following people. Host, producer, writer, Tom Merritt. Host, writer, Jason Howell. Co-host, Sarah Lane. Co-host, Rob Dunwood. Co-host, Jen Cutter. Producer, Anthony Lemos. Producer, Roger Chang. Editor, Hammond Chamberlain. Editor, Victor Bognat. contributing producers Kevin Tech, Noel Cow, and Brandon Richards, science correspondent Dr. Nikki Ackermans, social media producer and moderator Zoe Detterding, our mods, Beatmaster, Wscottis1, BioCow, Captain Kipper, Steve Guadarama, Paul Reese, Matthew J. Stevens, a.k.a. GadgetVirtuoso, and J.D.

40:56Galloway, mod and video hosting by Dan Christensen, music provided by Martin Bell and Dan Luters, art by Len Peralta, A-Cast ad support from Ali Gayo and Patreon support from Bobby Wagner. And thanks to all our patrons who make this show possible.

41:21The DTNS family of podcasts, helping each other understand. Diamond Club hopes you have enjoyed this program.

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From the publisher

Full details from Apple's WWDC next Monday are leaked and we wonder why this always happens, and Dr. Niki tells us how we might someday regrow our teeth.


Starring Jason Howell, Jenn Cutter, and Dr. Niki Ackermans.


Show notes found here.

Hosted on Acast. See acast.com/privacy for more information.

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