In short
Listener Questions #46 answers three questions—(1) how tick bites can cause an allergy to mammal meat (Alpha-gal syndrome), (2) whether aliens could experience quantum superpositions despite “decoherence” and Wigner’s friend constraints, and (3) a follow-up about daisy-chaining Wigner’s friend and causality.
Guests (co-hosts)
Daniel is a particle physicist who studies aliens/quantum ideas (co-host). Kelly Wintersmith is a parasitologist who studies parasites in space and explains biology/physics questions (co-host).
Key claims
- Alpha-gal allergy can follow bites from ticks (especially Lone Star ticks). After a delay (weeks), eating mammal meat triggers reactions 3–6 hours later.
- The allergy is to a sugar (alpha-gal), not a protein; ticks may introduce alpha-gal into the bloodstream while feeding.
- Quantum “seeing” depends on interference and coherence; big, messy brains cause decoherence, and Wigner’s friend limits interference access for an observer inside the system.
Notable examples
- Cetuximab drug reactions helped identify alpha-gal.
- Rocky Mountain spotted fever/tick exposure correlations.
- Self-experimentation by Dr. Platts-Mills (biopsy scars).
- Wigner’s friend “cat box” daisy-chain causality: linear quantum evolution prevents cross-terms; causality remains consistent.
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VOHosts Share Personal Stories
1:05 to 3:35
Daniel and Kelly discuss their surprising experiences as adults, including humorous anecdotes.
“When Republicans are messing up, I say it.”
Introduction to Listener Questions
3:35 to 7:19
The hosts introduce the listener question format and highlight audience engagement.
“Welcome to Listener Questions episode number 46.”
First Listener Question: Tick Allergy
7:19 to 7:55
Zach asks about developing a meat allergy from a tick bite, prompting a technical explanation.
“I've heard about a tick that can make you allergic to meat.”
Understanding Alpha Gal Syndrome
7:55 to 14:00
Kelly explains the science behind Alpha Gal syndrome and its connection to tick bites and meat allergies.
“The idea that you could pick up an allergy to a very common food just by getting bitten by an insect, that's terrifying.”
Understanding Alpha-Gal Allergy
14:00 to 18:04
Explore the surprising link between Lone Star ticks and meat allergies.
“And one of the things that he emphasizes in his career is that you need to be like open to things that are surprising.”
Tick Bites and Meat Consumption
18:04 to 20:56
Learn about the implications of tick bites on meat consumption and allergies.
“And apparently if you are the kind of person who itches for more than two weeks after you get a Lone Star tick bite, you are more likely to develop an allergy to meat.”
The Rise of Meat Allergies
20:56 to 21:56
Discuss potential reasons for the recent increase in meat allergies related to environmental changes.
“And Zach, did this slate your thirst for Alpha Gal info?”
Listener Question: Quantum Effects and Aliens
21:56 to 22:50
Zach number two asks about alien experiences with quantum effects.
“Also, what purpose does alpha-gal serve in mammals?”
Alien Perspectives on Science
22:50 to 28:00
Explore how alien senses may alter their understanding of the universe.
“I can make a brain for you, and then we can test what draw is the best for your brain, as opposed to his brain.”
Senses and Alien Experiences
28:00 to 29:44
Exploring how our senses might limit our understanding of alien experiences and quantum interactions.
“And so, for example, you know, when we see images from the James Webb Space Telescope, they're shifted into the visible range.”
Show all 22 chapters
Understanding Quantum Amplitudes
29:44 to 31:36
Delving into the concept of quantum amplitudes and the relationship between observers and quantum phenomena.
“And so Zach's comment essentially is like, hold on a second.”
Seeing Quantum Weirdness
31:36 to 34:13
Discussing how quantum interference occurs and the conditions required to observe it.
“with it, meaning that now we can think about them together as one quantum system with two states.”
Decoherence and Its Implications
34:13 to 37:09
Examining the concept of decoherence and why it prevents us from observing quantum effects in large systems.
“And in the same way, to get those interference effects, you have to get those phases of those waves to be just lined up.”
Wigner's Friend Thought Experiment
37:09 to 41:24
Explaining Wigner's friend scenario and its implications for observation and entanglement in quantum mechanics.
“It's like washed out across too many different states.”
Alien Consciousness and Experience
41:24 to 42:05
Speculating on the nature of alien consciousness and its potential to experience quantum effects differently.
“And so he can't use his memory, which is also inside the system, to observe quantum effects by crossing the wave functions.”
Understanding Alien Consciousness
42:05 to 46:42
Explore the complexities of alien consciousness and experience.
“Like, maybe number one, maybe it's very, very small, right?”
Zach's Follow-Up Question
46:42 to 47:42
Listen to a child's intriguing question on quantum observation.
“Well, this was a very complicated question for a seven-year-old.”
Causality in Quantum Mechanics
47:42 to 49:51
Delve into the mechanics of causality and observation in quantum contexts.
“And as we say down in Antarctica, good day, mate.”
Exploring Uterine Fibroids
53:46 to 56:00
Learn about fibroids, their impacts, and common misconceptions.
“All right, our last question of the day is from Senia about fibroids.”
Understanding Fibroids: Size, Symptoms, and Impact
56:00 to 1:02:15
Learn about fibroids, their commonality, symptoms, and their non-cancerous nature.
“And sometimes these growths, they can be small.”
Understudied Women's Health Issues
1:02:15 to 1:03:56
Discover the lack of research on women's health problems and its implications.
“unfortunately, is that women's health problems are very understudied.”
Listener Response on Fibroids and Research
1:03:56 to 1:05:14
Hear a listener's thoughts on fibroids and the importance of ongoing research.
“So I'm sorry to be giving sort of a sad answer, but I think that's exactly what the listener expected when they sent this question.”
Transcript
Automatic transcript. May contain errors.0:00This is an iHeart Podcast. Guaranteed human. I'm Maria Garcia. You may remember me from my podcast, Anything for Selena or My Dibble. I love pop culture. I think about stuff like, what did Mariah Carey and Luis Miguel's relationship mean? Why was the world so unfair to our girl, Britney Spears? And why do some women yearn for Shakira's black hair to make a comeback. I'm always trying to find the meaning behind pop culture and beyond. And now I'm back to unpack more divas, more drama, more stories from the present and the past that I'm muy excited to tell you about. We're going to have fun, we're going to keep it cute, and we're going to figure out what it all means.
0:51Listen to Muy Excited with Maria Garcia as part of the My Cultura podcast network available on the iHeartRadio app, Apple Podcasts, or wherever you get your podcasts. When Democrats are messing up, I say it. When Republicans are messing up, I say it. I'm Essie Kupp, a journalist and political commentator. And on my podcast, Off the Cup, I help you make sense of the often nonsensical news. I do this on cable news too, but on my podcast, I can really let loose and be my honest, unfiltered self. I just want to talk about something that happened this week because it's so bonkers, so stupid, such incredibly bad politics.
1:33We have to talk about it. Come for the hot takes, stay for the sanity. Listen to Off the Cup on the iHeartRadio app, Apple Podcasts, or wherever you get your podcasts. I'm Mange Shatikular, and I'm back with a new season of my podcast, Skyline Drive. This time I talk to scientists, biopunks, curmudgeons, blues owners, super seniors, and Goa's top cryotherapy lab to try to understand this obsession with living forever and what it means for all of us. And I get into a bit of trouble along the way. I'd say probably start bone smashing. That doesn't work. Make it look more defined. They say it works.
2:06I don't know. Listen to Skyline Drive, How to Live Forever, on the iHeartRadio app, Apple Podcasts, or wherever you get your podcasts. This is Michael Rappaport, and my podcast, the I Am Rappaport Stereo Podcast, is unlike anyone you've ever heard. If you're looking for strong opinions about sports, entertainment, politics, pop culture, and whatever else catches my attention, then subscribe now. This kid Jafar Jackson should absolutely, positively get nominated for his portrayal as Michael Jackson. Listen to I Am Rap Report on the iHeartRadio app, Apple Podcasts, or wherever you get your podcasts.
2:51I was once a happy carnivore, but after a visit from Lone Star, it's meat no more. Begrudgingly, I'm an herbivore. And while I miss steak tartare, it's not worth dying for. I tried to get some internal rhyme in there, and I don't think it went the way I imagined it would. No, I think you're basically the M &M of science at this point. Yeah, okay. If alien brains are strange and quantum mechanical, could they see quantum effects or was Daniel being over-dramatical? Up to 80 % of women will have uterine fibroids by the time they turn 50, but they're understudied. Wouldn't equal representation in medical research be nifty?
3:34Whatever questions are keeping you up at night, Daniel and Kelly's answers will make it all right. Welcome to Listener Questions episode number 46.
3:57Hi, I'm Daniel. I'm a particle physicist who thinks about aliens, and I'm the only co-host who hasn't been invited to rap on someone's album. Hello, I'm Kelly Wintersmith. I study parasites in space and it is yet to be determined whether or not, A, that will happen or B, that was a good decision on that person's part to invite me to do so. I think you have an awesome voice for rapping, Kelly. Oh, sure. Yeah, thanks. I'm not sure the poems help make that argument, but that's okay. What is the most surprising thing you have found yourself doing as an adult where you were like, I just did not imagine I would ever be doing this?
4:40Because if I do the rap thing, that will be my answer. I've had some funny moments recording ads for the podcast in the past. I remember recording one for Starbucks Nitro Cold Brew that Katrina listened to and convinced her to get a Nitro Cold Brew one day. That's amazing. And now she says every time she goes to Starbucks and she sees that drink, she hears my voice in her head, nitro cold brew. That's amazing. That's kind of cute, too. How about you, Kelly? You've ended up in some pretty funny situations in your science communication career. Yeah. I mean, I don't know if I wasn't limiting the question on purpose to science communication career.
5:20I mean, I remember donning a wetsuit pretty soon after the ice had melted in northern Wisconsin and swimming around to monitor the behavior of male largemouth bass as they were guarding their nests. And one of them came over and slammed me in the face and knocked my goggles off. I mean, he's not that big, right? It was mostly just cute. But, like, he was defending his nest. And I was just, like, amazed because I'm so much bigger than he is. And then I ended up in the ER for an ear infection. and I was in the ER for the third time and the woman was like, you're back? Why do you keep getting into the water?
5:56And I was like, well, I'm studying the reproductive behaviors of male smallmouth bass. And it was like, she was kind of listening and she goes, oh, okay, that's interesting. And then it like, once she processed what I had actually said, she said, to you, that's interesting to you. And I was like, oh my goodness, I'm suffering. Anyway, I think that was like, that whole summer I was like, I did not imagine that I would be in this situation. And people talk a lot about peeing in their wetsuits when they have that job. And I just remember thinking, I thought I was going to med school. This is, what a strange place I've ended up.
6:29But I'm getting face slapped by fish. Wow. That's right. That's right. So anyway, I don't know, that was a surprising path. I also got slapped by a leatherback sea turtle and that hurt a lot. That does sound like it wouldn't be fun. Well, today we are slapping nobody, but we are answering questions that are interesting to you, hopefully. Nice. Because everybody out there is interested in how the universe works. And we have the best listeners, the most curious listeners, ones who think about how things work. And sometimes those ideas don't click together just right or bump up against each other in an uncomfortable way.
7:02People write in to help us sort it out. We love hearing from y 'all questions at danielandkelly.org. And today we're answering three fascinating questions about biology and physics, two of them from people named Zach. Yes, it's a Zach-y sort of day. And so let's go ahead and hear our first question from our first Zach. Number one, Zach. Hey there, Extraordinaries. I've heard about a tick that can make you allergic to meat. I'm allergic to pollen and avocados because my dad is allergic to pollen and avocados. It's genetic. So how the heck can you get an allergy to meat from a tick? You're the parasitologist, Kelly, so I'm tossing this one to you.
7:49Thanks in advance. Wow. Number one, Zach. All right. Okay, this is fascinating and terrifying. The idea that you could pick up an allergy to a very common food just by getting bitten by an insect, that's terrifying. Absolutely terrifying. I'll note ticks are not insects, but still terrifying nonetheless. They're arachnids, so we're related to spiders and stuff. But what's really amazing to me is that we ever figured this out. OK, so here's the deal. You get bit by a tick and then some period of time after that can be weeks or whatever. You build up an allergy to meat and then you eat meat. And three to six hours after you've eaten meat, you have an allergic reaction.
8:31So the fact that we were ever able to connect those dots is like mind blowing to me. But let's take a step back and talk about like how we figured this out. Yeah. So over a decade ago, a bunch of allergists were getting reports from people who were saying, I've developed an allergy to meat. And their initial response was like, it's probably something else. Because allergies to meats don't happen? Yeah. I mean, allergies to meat are just very uncommon. It's not a thing that has been documented a lot in the past. And so I think a lot of people were like, OK, well, you know, you should avoid meat then.
9:06But this is very surprising and doesn't fit with what we know about allergies. So allergies in general, like I'm familiar with, I'm allergic to a cat and it makes me sneeze or get hives or I'm allergic to grass and I get a rash. Or if you're allergic to foods like peanuts, then when you eat them, your throat can swell. Is that what's happening when you're eating meat? You're getting a throat constriction or is it more like affecting digestion where you're vomiting it? It could be all of the above. So it sort of depends on who you are. But so you can have, let's call it gastrointestinal distress.
9:37You can get covered in hives or you can get anaphylactic shock where essentially your throat starts to close. So it's very clearly an allergy. Yes, very clearly an allergy. Because gastrointestinal distress after eating meat could also be caused by like E. coli or something else, right? Yeah, sure. Right. If you eat bad meat, you can get the runs or whatever. But this is like every time you eat meat, you reliably get this response. And so it's probably not a batch of bad meat. It is just the way your body responds whenever it encounters certain kinds of meat, meat from mammals in particular. This calls up some memory I have of my younger brother eating camembert for the first time.
10:15I think he was like six. And I was like, wow, this is so delicious and creamy. And he was like, creamy? This is spicy. And I was like, spicy? What are you talking about? He's like, yeah, it's really spicy. And then I discovered, oh, he's having an allergic reaction. It was like stinging as he was eating it. And he had it was spicy because he was only like six or seven. And so, yes, then at the ER, I had to relate this story to the doctor. And my parents were like, why didn't you say something? Anyway. Oh, my. What was he allergic to? Camembert, yeah. But just the cheese. Some soft cheeses. Yeah.
10:49Because they all have different molds. Okay. And so some people are allergic to specific cheeses. So if you're eating a hamburger and it's not supposed to be spicy, and it is, you might have this allergy. So here's the thing. You usually don't respond at all for three to six hours, which is kind of weird. And so often when you have an allergy, your immune system has essentially decided that something you've consumed is bad, even though it's not. So, for example, there are proteins made by peanuts and our bodies will produce immune cells that are constantly circulating. Whenever they see proteins from a peanut, they decide that there is an invader that must be attacked.
11:27And they're bringing along other immune cells. And when they find the peanut, those immune cells like burst open and create like a massive inflammatory response to try to destroy what they think is a harmful invader. But actually, it's just, you know, this thing that isn't really going to hurt you. Peanuts aren't going to start replicating and trying to like take over your lungs or something. They're just something that's there because you ate a peanut. Right. So in general, an allergic response is your immune system responding to something that's benign. Yes, right. Okay. So there was this cancer drug that came out called cetuximab.
12:05Matt, I want you to keep all of those attempts in there. Yes, sir. Oh, come on. Cetuximab or something like that. And very unfortunately, there were some people that were taking the cancer drug and they would die. Oh, no. And they clearly were dying from an allergic reaction to the drug. So allergists were called in and the allergist started like looking at the people who have allergic responses to this cancer medication and those who don't. And it turned out that this cancer medication had a sugar in it that we usually just call Alpha Gal and has a much longer chemistry name. But none of us want to hear that, least of all, Daniel.
12:41So we're just going to call it Alpha Gal. Alpha Gal sounds like a teenage superhero. It does. Yeah. No, it sounds awesome. Let's call Alpha Gal to solve this problem. But now it's also become the name of the allergy. So if you have Alpha Gal syndrome, you know, you don't have amazing superheroes who come to get you out of trouble. You get anaphylaxis when you have a hamburger. Much less cool. That's not a very cool superpower. No, no. And so they were trying to figure out like, OK, this sugar is what's causing the allergy, but it doesn't cause the allergy in everyone. And so they started like laying maps of different like kinds of diseases from the United States over the maps of areas where people were getting allergic reactions to this drug.
13:25Such cool detective work. Yes, right? This is like cholera episode all over again. I know, which was such – I had so much fun researching that episode. And so anyway, somebody after looking at maps and maps and maps and maps of diseases noted that the areas where people were more likely to get allergic reactions to this drug overlapped with areas where people were likely to get Rocky Mountain Spotted Fever, which is a disease that you get from ticks. And so they reached out to a bunch of people and they were like, do you remember getting bit by a Lone Star tick? tick and when they asked people some of them were like yeah i got bit by a lone star tick you know a year ago and then they'd be like oh well did you start also like responding strangely to meat because meat also has alpha gal sugars in it and they'd be like yeah i get these hives now after i have a burger and they were able to like create this correlation amazing i know it was totally incredible they must have been so skeptical of this connection when they first saw that like what how could it be this no but then you know that's the thing about science the data speaks right Yeah, well, and so one of the amazing, this problem was solved concurrently by scientists in Australia and a scientist at the University of Virginia named Dr.
14:37Platts Mills. And one of the things that he emphasizes in his career is that you need to be like open to things that are surprising. Yeah. And so when people were like, I'm allergic to meat, you know, he admitted that he was like, yeah, allergic to meat. And then but he's like, but, you know, I listened. And then a lot more people were like, I'm allergic to meat. And he I think he was part of the team that figured out this alpha gal sugar thing. And then it turned out that he went on a hike once and he walked through an area where Lone Star ticks had been breeding. And he picked up a bunch of baby Lone Star ticks.
15:10And now he has this disease. Oh, no. And so he's been experimenting on himself. I found a quote where he said, I'm covered in biopsy scars from doing research on myself. So I think he'll like eat a little meat and then be like, boop, biopsy to collect some data. And he takes a little bit, a little sample of himself. So here's a couple additional things that are like surprising about this. So usually allergies are to a protein. Alpha-gal is a sugar. That's weird. Usually you don't get allergies transmitted by organisms like ticks. And to be honest, we don't know why ticks are giving us this allergy.
15:46So we know that ticks, sometimes when they're taking a blood meal, they definitely spit in you while they're taking the blood meal to add insult to injury. What they're spitting in there is like anticoagulants and other things to make sure the blood flows nicely into their face. But when they essentially spit into you, they have this sugar and they're putting it into your bloodstream and your bloodstream responds by creating this allergic response. but not always. So hold on a second. Ticks spit some stuff into you. I get it. But one of those things they spit into you happens to also be a sugar that's in like hamburgers.
16:21Is that coincidence? So we don't understand, right? So that's a great question. So this sugar is made by almost all mammals, but not humans and some of our close primate ancestors. Weird. We don't totally understand why we didn't make it. But this sugar is one of the reasons why it's hard to do transplants of pig hearts into people because pigs do make this sugar and our bodies, our immune systems respond to pig hearts. And so one of the things that people are doing when they're genetically manipulating pigs to try to make it so that their organs can go into people is they're removing the genes that cause the pigs to make this sugar.
16:58And so does that mean if you have this allergy, you can't eat a hamburger, but you could eat a people burger. Oh, I should have known. All right, bing, cannibalism. I want an answer to my question I wasn't just going for the points the answer is yes you would not have anaphylactic shock if you ate a human burger a Daniel burger also you won't get anaphylactic shock if you eat chicken for example because this is a protein that you tend to find in mammals so pigs, cows bacon would give you hives or something like that if you have this reaction well I don't eat a lot of mammals anyway and I'm not a big fan of eating mammals So this is feeling less apocalyptic to me, but it's still a fun science puzzle.
17:43Well, I have some neighbors in my community who have this allergy because one of the hotspots is central Virginia where I live. And I have some neighbors who raise cows for like a living and they have this allergy now. So they can't, you know, they can't eat the cows they raise. They have to like sell that meat to other people now. And so, you know, for some people it is a pretty big problem. Yeah. And apparently if you are the kind of person who itches for more than two weeks after you get a Lone Star tick bite, you are more likely to develop an allergy to meat. And I definitely have a tick bite that's been itching for more than two weeks.
18:17And so last night I went out to eat and I was like, do I have the burger? Do I not have the burger? And like, anyway, so I'm starting to worry that I will eventually have this. And did you have the burger? I did have mammal meat and I was fine. My back kind of hurts. Oh, man. That sounds so unappetizing. It does sound unappetizing. Mammal meat. Yeah. It's like, I'll have the mammal meat burger. I don't really care which one. Just throw in some mammals. Just some mammal. You can mix them all together. I'm fine. Whatever. A little raccoon burger. Oh, never mind. All right. Okay, so there's a couple things we still need to figure out.
18:52Why is it that some people get bit by Lone Star Ticks and don't get the allergy? Yeah. We don't really know. I mean, I guess that's sort of similar to the question for why are some people allergic to peanuts and others aren't. But there's also lots of other immunoresponses that we don't understand. You know, for example, like 1 % of people get type 1 diabetes, but something like 30-something percent have the genetic disposition for it. There's some environmental trigger. And so there must be some combination of being bitten by a tick and something else. You're also like struck by lightning or were sick beforehand or some other environmental combination.
19:27Yeah, yeah. I mean, loads of job security if you work in the field of allergies. There's a lot we don't know yet. And it seems like there's some ticks whose bites are more likely to give you this allergy. It's not just Lone Star ticks. There are ticks in Australia that do it, ticks in Europe and Africa that do it. But not every tick bite is equally likely to give you this allergy. And so trying to figure out what it is that makes some ticks more likely to make you allergic to meat is an open area of investigation. And so one of the things that I was wondering when I was doing this research is like, presumably this allergy has been around forever or like for a very long time because like Lone Star ticks have been around for a very long time.
20:08But we didn't figure this out until more recently. Right. But haven't tick bites been going up a lot? Yeah. So we think that tick bites have been going up and we don't know 100 % why, but some guesses are because deer numbers have been going up. And ticks, lots of ticks have deer as like a very important host. And since we killed the predators of deer and deer numbers are going up and they're encroaching in our habitats more, this might be why we are coming into contact with ticks like the Lone Star Tick more often. Wow, this is like Revenge of the Wolves. Yeah, that's right. We killed off the wolves and now we can no longer eat hamburgers.
20:44That's right. That's sinister. Yeah, yeah. I mean, this is some nasty stuff. So anyway, stay tuned to find out if Kelly can no longer have mammal burgers in the future and has to convert to cannibalism. And Zach, did this slate your thirst for Alpha Gal info? Thanks, Kelly, for the dive into this weird allergy, which I feel is definitely owed a place in Ripley's Believe It or Not. I was especially intrigued by the history of its discovery and the way it took input from so many different areas of science. allergology and oncology, epidemiology, parasitology. Given the usual way this allergy is framed, like becoming allergic to a hamburger, I had the impression that it was somehow an outgrowth of industrial intensive cattle farming.
21:33But it sounds like it might be driven more by different human behavior, namely more contact with wildlife as we encroach on their habitats, and maybe climate change, improving conditions for ticks. I'd be really curious to see if anyone has gone back in time to look for medical case studies on meat allergies. Has this happened before? Or if other parasites can cause other kinds of allergies. Also, what purpose does alpha-gal serve in mammals? And why don't other taxonomic classes of animals have it? These are good things to ponder as I toss a dry brined ribeye steak on the grill this weekend while I still can.
22:14I hope by the time this airs, you and Zach number two can still enjoy one too. Thanks again.
22:30I'm Munga Shatikula and I'm back with a new season of the podcast Skyline Drive. This time I'm diving into a rabbit hole of peptides, organoids, blood boys, blue zones, and brain replacement to try to understand what this longevity obsession is all about and what it really means to live forever for all of us. I learned about some rad science. I can make a brain for you, and then we can test what draw is the best for your brain, as opposed to his brain. Here are some hard truths. I would expect Indians to age faster, but I did not expect it to be almost a four to five year acceleration. And get myself into a world of trouble.
23:15I'd say probably start bone smashing. That doesn't work. Make it look more defined. They say it works. I don't know. Listen to Skyline Drive, How to Live Forever on the iHeartRadio app, Apple Podcasts, or wherever you get your podcasts. We've all been there. We've had seasons that have shaken everything. The question is, what remains when the shaking stops? Hi, I'm Gary Valenciano, and on my podcast, Unshaken with Gary V., I sit down with amazing personalities and we talk about the seasons that nearly broke them, the lows that carried them to their highs. Listen to Unshaken with Gary V. on the iHeartRadio app, Apple Podcasts, or wherever you get your podcasts.
24:04This is Michael Rappaport and my podcast, the I Am Rappaport Stereo Podcast, is unlike anyone you've ever heard. We're a variety show and if you're looking for strong opinions, funny opinions about sports, entertainment, politics, pop culture, and whatever else catches my attention, then subscribe now. This kid Jafar Jackson is as good as Rami Malek as Freddie Mercury, and it's as good as Timothy Chamillai as Bob Dylan. And I say that with love and respect for both of those actors. And I don't know how many Oscar nominations they give out. I don't know if it's five, six for best actor. 150 % this kid Jafar Jackson should absolutely positively get nominated for his portrayal as Michael Jackson.
24:52Listen to I Am Rappaport on the iHeartRadio app, Apple Podcasts, or wherever you get your podcasts. I Am Rappaport Podcast. Bill, why is my eye twitching? Does this mean I'm in perimenopause? Maybe I have adult ADHD. I need to look this up. Where's my phone? Juliana, your phone is hot to the touch. I think it's asking you for a break. You know what? Maybe I should just ask chat GPT. Or maybe we can ask an actual human. Yes, like a couple sex therapist. Whoa, that escalated quickly, but okay. Because I have questions. We have questions. And I bet everyone has questions. Like, is it normal to sleep in separate bedrooms?
25:32We do that. How about this one? Is bribing your kids bad parenting or just negotiating? Oh, and I still do need to know, why was my poop green that one time? Hypothetically, right? Okay, well, instead of letting the internet guests, we've got actual people answering these exact questions. And laughing with us has got to be better than spending three hours down a rabbit hole online. Listen to Bill and Juliana, the podcast on the iHeartRadio app, Apple podcasts, or wherever you listen to your podcasts.
Read the full transcript
26:14Okay, next up we have a question from Zach number two, the second tier, Zach. Let's go. Hi, Daniel and Kelly. My name's Zach Wienersmith. I'm a seven-year-old girl from Indonesia. I was listening to your discussion on Inner Cosmos, and you referred to this idea of an alien being able to experience quantum effects. And it was my understanding that once you're entangled with some system, you can't see quantum amplitudes. You can see, like, the effects of the interference, and you can use wave functions to predict them. But I did see how it would be possible to have a, like, sensory apparatus that couples to some system without eliminating quantum weirdness.
26:58Like, if you looked inside a Schrodinger's cat box that had two cats in it, presumably the cats don't see each other as quantum. Only you outside the system do. And similar for the Wigner's friend thought experiment. Love the pod. Thanks for answering my question. This Zach doesn't sound to me like a seven-year-old girl from Indonesia. What do you think? Are we being pranked? You know, we might be being pranked. And I don't want to judge any seven-year-old girls for having deep voices. However, I do suspect that maybe this is the Zach that lives at home with me. Well, here's hoping that Zach number two climbs in the rankings and one day reaches Zach number one status.
27:44Well, it's a tough competition, but I wish him the best of luck. All right. Well, this is a great question from Zach. Thank you very much. And some background. What he's referring to is some speculation I've done in my recent book, Do Aliens Speak Physics? Where I was wondering about how aliens might do science and if they think about the universe the same way. and was speculating that something that influences the way we think about the universe that we might not always be accustomed to confronting is our basic senses, that the way we see and the way we hear and the way we touch influences our sort of internal mental intuitive language and the answers we express about the universe.
28:25And so, for example, you know, when we see images from the James Webb Space Telescope, they're shifted into the visible range. Or when we talk about what is a quantum particle? We try to express it in terms that are familiar to us. And often that's not really possible. And so I was wondering if aliens could have a really alien experience in a way that couldn't be translated to our experience. And one way to imagine that is to think, well, we struggle to experience quantum effects. Is it possible for there to be aliens to have such a different experience that they could, for example, interact with the quantum world in a different way and have a different kind of experience, a superposition experience where you're like seeing two states simultaneously.
29:09You know, imagine like a photon that might hit your left eye or your right eye. We see it hit your left eye or your right eye. But is it maybe possible for an alien to like experience both branches of that wave function? And I just want to interject to say that another thing I enjoyed about your book is that you talk about how animals experience the world differently and how we can maybe use that to think about how aliens might experience the universe differently. Yeah. Since we haven't met any aliens yet, we're limited to what we can study here on Earth. And already here on Earth, we see a huge variety of senses and likely experiences.
29:41But of course, we can't really tap into that. And so Zach's comment essentially is like, hold on a second. Is it possible to experience quantum weirdness? Maybe there's some constraint from quantum mechanics here that tells us already that Daniel's fanciful speculation is impossible. And he says, once you're entangled with some system, you can't see quantum amplitudes. And is Zach right or is Daniel right? The short answer is that since we're talking about experience, there's a consciousness aspect to this, which means that physics can't cover this whole question. And I'm going to drive a huge truck through that loophole at the end here.
30:23But let's back up and talk about quantum amplitudes and seeing quantum stuff. What does that mean? What are we talking about here? Let's give the background to Zach's question. And I think the first thing to talk about is like, well, what do we mean when we say seeing, right? We're experiencing the world somehow. And so simplify the whole thing from like the world and a person, whatever, and just imagine you have like a photon. That's the thing you're trying to see. And then you have the eyeball. That's the sensor that's trying to see it. Okay. And so in physics, when we say take a measurement, what we do is we try to use some sensor and we try to use the world to change its state so that we can read it out.
31:02Right? So for example, I have this sensor that's my left eyeball and my right eyeball. And I shoot a photon that might go to the left or to the right. And then I want the left eyeball to indicate if it hits the right, right? Very basic. And so the idea is to correlate the sensor with the photon, right? You want a correlation between the two. If it's going to go to the left, you want the left sensor to zing. And so this is really quantum entanglement. We want to entangle the sensor with the photon. If the photon has a possibility to be left or right, then we want the sensor to be entangled with it, meaning that now we can think about them together as one quantum system with two states.
31:47Instead of it just being the photon that could be left or right, now we have the whole system, the photon and the sensor, and there's two states. One state is the photon went left and the sensor read left, you saw it in your left eyeball. The other one is the photon went right and your right eyeball saw it, right? So you just align the sensor with the photon and you're entangled them because now the off diagonals are not allowed. By off diagonals, do you mean you can't make type one or type two errors? Yeah, exactly. You've entangled them, which means that like photon going left, but right eyeball seeing it is no longer allowed.
32:23In the same way, we talk about entanglement from like particles spin up and spin down. If one is spin up, the other one has to be spin down. That's just a constraint, right? It's a constraint on the possible outcomes. And that's what entanglement is. And that's what's happening here. So the sensor measures it, meaning you've entangled the sensor with the system, with the photon. Okay. And you can just say that, you can be like, and no mistakes. I mean, especially with human eyes. Yeah, no, we're here and we're imagining a perfect sensor, but you could definitely add off diagonal elements here from imperfect sensors, absolutely.
32:57And so this isn't destroying quantum behavior. Entanglement itself is quantum behavior, right? This is all entanglement is. And Tanglewind seems fancy and spooky and whatever, but it's just correlated outcomes, essentially. And there's some subtleties there because you can have quantum versus classical correlations. But right now, we're just talking about correlated outcomes. And so the idea is the sensor and the eyeball are now in a superposition of both possibilities. They're connected and they're not independent. And so if you have a system like we've just described, the photon and the eyeball, you can see quantum weirdness.
33:30You can see interference effects between two branches of the wave function, like the double slit experiment, right? We see interference between the two branches. The photon could have gone to the left slit, could have gone to the right slit. Those two possibilities interfere with each other. We see weird quantum effects like interference, right? So that's what we mean by seeing weird quantum effects. So why don't we see those kind of quantum effects all the time, right? Like why don't we see cats interfering with themselves or baseballs having interference patterns, et cetera, et cetera. And the answer is that you need more than just superposition, in order to see interference, you need something else in addition.
34:07These quantum wave functions are waves, right? They go up, they go down, they wiggle, just like waves in the ocean. And in the same way, to get those interference effects, you have to get those phases of those waves to be just lined up. They have to go up at the right time or down at the right time, so they cancel each other out or they add up together. In order to get nice acoustic effects Because in a room, you need all the sound waves to be like coherent. So they like add up in the right way or cancel each other out in the right way. You have noise canceling headphones in your ear that cancels the sound by producing a coherent opposing wave, right?
34:43It's like lined up just right. So you need these waves to be lined up just right. They need to not only for there to be multiple possibilities, but you need them to be like lined up just right to have the interference effect. Still with me? I think so. So does seeing quantum effects mean that you would also be able to observe these waves in some way? Because to see quantum effects, you sort of need to know why you're getting one answer and not the other? Well, in the case of these quantum amplitudes, you can't see them directly. You can only see the interference effects. The quantum amplitudes are hidden.
35:15But you can see the interference effects without seeing the waves directly, which is why it's so cool. Because that's one way that we reveal that there really is a superposition there, is that we see the interference effects. All right. So to see quantum interference, what you need is a superposition. You need two possibilities at once, and then you need them to be coherent, not scrambled. Like if you scramble the phases of one branch, then you wouldn't be able to see any interference because it would just all be randomized. And you have to bring them into contrast, right? To bring those waves together and say, okay, add up or okay, cancel each other out.
35:50And this is how quantum computers work is they have a bunch of qubits, which can be in a superposition of states. And then you operate on those. In the end, you make a measurement which brings them together. You have the superposition, you have the interference, you get some quantum state. And so you could take advantage of the superposition and all the quantum weirdness, and quantum computers definitely take advantage of all that quantumness. Okay. Okay. So why can't we see cats and baseballs and whatever doing quantum interference? why can't Zach see quantum weirdness in his everyday life? And the answer is two reasons, right?
36:27So number one is Zach is big and messy, right? So he is, I mean, we've all seen his office. We know about the Doritos bag and whatever. But the device I described earlier, the simple idea of an eyeball that either indicates yes or no, I've seen a photon. It's a very simple device. and you can entangle that with a photon and keep everything crisp and see quantum effects. But in reality, an eyeball is big and it's complicated and it's connected to a brain, which is big and it's complicated and you cannot describe it with one internal state. It's not like the eyeball can say yes or no. It's like a huge, messy system with lots of different internal states.
37:10And so the superposition is still there and the entanglement is still there, but it's spread out across so many internal states inside Zach's eyeball and inside his brain that you're never going to be able to bring these things together to contrast them in the way you need to see quantum interference. It's like washed out across too many different states. It's like if you have a teaspoon of salt, you can taste a teaspoon of salt. You put it in your mouth, it's very salty. But if you add it to an enormous vat of beans, it's still there. right? It's changed it a little bit, but you can't even really tell necessarily this salt in there.
37:48This is like adding a teaspoon of salt to a planet of beans, right? The quantum effects are small, and Zach's brain is really, really big compared to a quantum system that it's essentially just lost. That information is still in principle there, but it's basically washed out. So this is called decoherence for those who want to learn more about it. When you have quantum effects, but they're essentially unrecognizable and unrecoverable because they're averaged out over a big, messy system. So does that suggest that for an alien to be able to observe quantum effects, they would have to have a very, very, very simple brain?
38:26Yeah. And they're not going to be able to tell you the secrets of physics? Well, it does. We're going to get there in a minute, but essentially it suggests that you can't have a human-like brain. Okay. And so that's one reason why Zach can't see quantum effects is decoherence. But there's another one that he raises, which I think is much more interesting, which is that he's inside the system. He's entangled with the system, right? And he mentions this cool experiment, Wigner's friend experiment. And so Wigner's friend says like, all right, you have a cat in a box, right? Schrodinger's cat. The cat is in the box.
39:01You don't know if the cat is alive or dead. Now let's say that Zach is doing that experiment. I mean, he has the cat, he has the box, but Zach himself is inside another box. Oh no. Okay. And Kelly is outside the box. Now, Zach, inside the box, he opens up his own box and he can tell if the cat is alive or dead, right? Okay. Okay. But Kelly has not yet opened up the Zach box. So she doesn't know whether Zach has seen the cat alive or Zach has seen the cat dead. Okay. Okay. So according to Kelly, Zach himself is in a superposition. He's entangled with the cat. If the cat is alive, there's a version of Zach that has seen a live cat.
39:43If the cat is dead, there's a version of Zach that has seen the dead cat, right? But from Kelly's point of view, both Zachs still exist as possibilities. So this is Wigner's friend experiment. And it argues that each of those individual Zachs see a live cat or a dead cat. There is no Zach that sees the superposition that sees the sum of live and dead cats somehow, even though Kelly on the outside can see the superposition. So this is the Wigner's friend experiment that he raises. And the crucial thing to understand here is that the reason Kelly can see the superposition, but Zach cannot, is that Kelly's brain is not part of the quantum system.
40:27Zach's brain is inside the quantum system. And so he can't, for example, see the two branches of the wave function interfere. Kelly could cause the two Zachs to interfere with each other and have weird Zach interference effects. That would be pretty awesome. Zach can't do that because he can't coherently manipulate his own memory and brain state from the outside while that brain is the thing doing the manipulating. You can't use your memory as the instrument that reaches in and re-superposes your memory and also observes it, right? So the thing that makes Zach and Kelly different in this scenario is not that Kelly has access to anything that Zach doesn't have.
41:07It's that Kelly's observation, her memory isn't part of the system, okay? So those are two separate things. One is like Zach's brain is too big and messy to keep quantum effects and recover them. And the other one is that Zach is inside the system. And so he can't use his memory, which is also inside the system, to observe quantum effects by crossing the wave functions. Okay. And so then is Zach's question essentially, wouldn't an alien be in the system? Yeah. And then so how could this possibly work? Yeah, exactly. So Zach is saying once you're entangled with some system, you can't see quantum amplitudes.
41:46And so I don't think I would agree with that statement exactly. I would say, you know, once the information has leaked uncontrollably into many degrees of freedom, like his brain, interference becomes effectively impossible. But let's do this point by point. So point number one, which you already alluded to, like, okay, what about being big and messy? And so, yeah, the idea here is like, well, maybe aliens have a brain that operates completely differently, right? Like, maybe number one, maybe it's very, very small, right? Because you have an alien that's effectively like a qubit. And so it can be in a superposition with a photon without being big and messy, keeping all of that coherence.
42:26But if you want an alien to experience that superposition, that's probably not going to do it because I don't think qubits experience anything. But already, we're bumping up against what do we mean by experience? How sophisticated does the system have to be to be conscious? We totally don't know. And that's the direction I was gesturing towards in the book, which is like, look, this whole business about experience is totally unknown. What is an alien experience like anyway? We don't even know what an octopus experience is like with their multiple brains. And so that's the loophole I'm basically driving this entire thing through.
43:00But, you know, it's also possible to imagine not just small brains that can maintain quantum coherence, but larger brains. Like we are currently trying to build quantum computers, which are larger and larger. And one of the challenges of that is keeping them coherent, keeping them from decohering by interacting with the environment. And we're getting better and better at that. And so you can imagine perhaps there's some alien out there who's got a brain that's effectively like a quantum computer, which can maintain these phases. And so, you know, it can somehow interact with a photon without decohering.
43:36But then you still have this question of like, can that alien experience it? The second point of like, you're inside the system. Can you experience the system from the inside since your memory is also inside? And here again, I'm just going to say like, look, experience is a fuzzy thing. We don't know what it means to experience it. And our sense of experience means like you see it with your eyeball, you record it in your memory, you then call that up, you think about it. What did I feel about seeing that photon? Or what did I feel about seeing that cat? And now we're speculating about what it's like to be an alien.
44:11And if you imagine an alien with like a quantum computer-like brain that can maintain those superpositions, then it's not important that the alien can construct interference, that the alien can bring the two sides of the wave function into contrast with each other to create interference effects. We're just talking about experiencing the superposition. So maybe this alien brain can exist across these two branches of the wave function. And there's some alien-like experience. This is totally hand-wavy, right? This is not supported by physics, but I think it's also not a question quantum mechanic answers because it depends on what does it mean to experience and whether it's possible to experience a superposition if your brain is very different and quantum mechanical coherent.
44:57So I would say to Zach, quantum mechanics doesn't say that's impossible, but it's not well enough to find, I think, really is the reason why there's a loophole there. Okay. One, clearly your writing process involves a lot of smoky banana peels. And two, so does this suggest that like if you track an organism through evolution, like when it realizes it's observing something, it would lose the ability to observe it? Because based on what you said, it's like you kind of need to know what's going on and be like conscious of what's happening. So could bacteria on our planet that don't know what's going on observe quantum effects and we don't realize it because they don't know what's happening, but we can't because we're like too smart for that?
45:41It's possible, but again, we don't know if bacteria experience anything. I mean, I can't even understand what it's like to be another human being, not to mention a bacteria. And so saying anything concrete about the nature of another being's experience is all just extrapolation from their outward behavior. And so we don't know. And that was essentially the point I was trying to make with my book is that, look, we want to make this sort of mental connection with aliens. We should be prepared for the fact that their internal experience could be so alien, we might not be able to map not just our ideas about physics, but our ideas about what it means to be alive and experience the world, the very basic nature of interacting with the world.
46:25They could have a very alien sense of that. And this is just part of the argument of the book of like, I don't know what aliens it's going to be like, but I suspect we haven't thought it through and it's going to be much weirder than we imagine. Maybe in this direction, maybe in that direction. And so I was looking for like, which parts of this are not crisply defined so that I can gesture vaguely in that direction. Well, this was a very complicated question for a seven-year-old. This little girl is going to take over the world one day. So let's go ahead and see what little Zachy Wienersmith had to say.
47:02Hello, this is Zach Wienersmith. I'm a nine-year-old girl from Austronesia, and I just wanted to say I appreciated the answer to the question. I was talking to some other kids here in Austria about it, and what we were wondering is, what happens if you do like a daisy-chain version of Wigner's Friend where there's like 80 outer layers of observers? how is it that when the topmost observer starts observing everyone down, you have causality maintained the whole way down? How does the universe do that off? We thought that would be nice to know. And thanks again. Big fans of the show down here. And as we say down in Antarctica, good day, mate.
47:49Hey, Zach, who's from Virginia but can't seem to admit it on the pod. Great follow-up question, but the key thing is that causality actually works the other way, bottom up rather than top down. So remember the setup here. We have an experimenter with a cat in a box. Until they observe it, the cat is in a superposition of alive and dead. Now you put that whole experiment inside another box with Wigner on the outside. So if the inner guy opens his box first, he gets entangled with the cat's alive or dead state. And for Wigner on the outside, the bigger box is now in a superposition of two states.
48:29One, the cat is dead and the inner guy says it's dead. And two, the cat is alive and the inner guy says it's alive. There's no cross term there where the cat is alive and the inner guy saw it dead. That's the crucial thing. The quantum evolution here is linear, so it acts on each term separately and can't mix them. When Wigner opens the outer box, he either sees a live cat and an experimenter saying it's alive, or a dead cat and an experimenter saying it's dead. So that's why causality goes bottom up. The correlation starts when the inner guy entangles with his box, and Wigner just joins a chain that was already consistent.
49:07You can do this 80 times and daisy chain them, but it doesn't change the basic setup. but still two branches, just a lot more guys entangled. Okay, but maybe does it depend on the ordering of the box openings? We described the inner guy going first. What if you do it the opposite direction? Well, that's not as interesting. If Wigner opens his outer box first, he finds the inner experimenter sitting next to a still-sealed box, just an ordinary guy with a superposition of alive and dead inside the box. The guy he sees is not in a superposition. And now Wigner is basically just part of the inner box experiment, and whoever opens the cat box entangles them both.
49:49So there's no causality issues. Causality still works bottom up.
50:02I'm Mungish Hatigular, and I'm back with a new season of the podcast Skyline Drive. This time I'm diving into a rabbit hole of peptides, organoids, blood boys, blue zones, and brain replacement to try to understand what this longevity obsession is all about and what it really means to live forever for all of us. I learned about some rad science. I can make a brain for you and then we can test what draw is the best for your brain as opposed to his brain. Here's some hard truths. I would expect Indians to age faster, but I did not expect it to be almost a four to five year acceleration. And get myself into a world of trouble.
50:48I'd say probably start bone smashing. That doesn't work. Make it look more defined. They say it works. I don't know. Listen to Skyline Drive, How to Live Forever on the iHeartRadio app, Apple Podcasts, or wherever you get your podcasts. We've all been there. We've had seasons that have shaken everything. The question is, what remains when the shaking stops? Hi, I'm Gary Valenciano, and on my podcast, Unshaken with Gary V., I sit down with amazing personalities and we talk about the seasons that nearly broke them, the lows that carried them to their highs. Listen to Unshaken with Gary Vee on the iHeartRadio app, Apple Podcasts, or wherever you get your podcasts.
51:58is as good as Rami Malek, as Freddie Mercury, and it's as good as Timothee Chalamet, as Bob Dylan. And I say that with love and respect for both of those actors. And I don't know how many Oscar nominations they give out. I don't know if it's five, six for Best Actor. 150%, this kid Jafar Jackson should absolutely, positively get nominated for his portrayal as Michael Jackson. Listen to I Am Rapaport on the iHeartRadio app, Apple Podcasts, or wherever you get your podcast. I Am Rapaport Podcast. Bill, why is my eye twitching? Does this mean I'm in perimenopause? Maybe I have adult ADHD. I need to look this up.
52:43Where's my phone? Juliana, your phone is hot to the touch. I think it's asking you for a break. You know what? Maybe I should just ask ChatGPT. Or maybe we can ask an actual human. Yes, like a couple sex therapist. Whoa, that escalated quickly, but okay. Because I have questions. We have questions. And I bet everyone has questions. Like, is it normal to sleep in separate bedrooms? We do that. How about this one? Is bribing your kids bad parenting or just negotiating? Oh, and I still do need to know, why was my poop green that one time? Hypothetically, right? Okay, well, instead of letting the internet guess, we've got actual people answering these exact questions.
53:21And laughing with us has got to be better than spending three hours down a rabbit hole online. Listen to Bill and Juliana, the podcast, on the iHeartRadio app, Apple Podcasts, or wherever you listen to your podcasts.
53:46All right, our last question of the day is from Senia about fibroids. Dear Daniel and Kelly, thank you so much for an awesome podcast and thank you for taking your time to looking into my question about fibroids. I just finished listening to your episode on perimenopause. I want to thank you, Kelly, for being so open about your own situation and for talking about this important topic. I'm 38 years old and I have a uterus and ovaries. So I'm especially concerned about this topic. I have a personal history with uterine fibroids. I have had severe problems for seven years or more. I've had surgeries and hormone therapy.
54:36And I've seen a lot of different doctors. they all seem to give very different answers to my questions about why we get fibroids and how they might affect fertility. Fibroids seem to be very common. To my understanding, it's estimated that 70 to 80 percent of women by the age of 50 will have fibroids. And that's just basically most women, yet we seem to know so little about them. So, like, did Mother Nature plan for this condition? Or is there a relationship with our modern lifestyle? And how come we know so little about a condition that is so common? I would love to learn more about this if you have the time to investigate.
55:27Thank you again. Bye. All right, Kelly, what is a fibroid? Well, first, I would like to prudently start by reminding everybody that I'm not that kind of doctor. I do not have a medical degree. So if you are concerned about any of this for yourself or your loved ones after hearing this segment, please go talk to an OBGYN or your family practitioner. OK, so what are fibroids? So fibroids are growths. And I think when most of us hear the word growth, we immediately think cancer. These are very, very rarely cancerous. But these are just places in the uterus where you start getting rapid growth of cells.
56:06And sometimes these growths, they can be small. They could be like, you know, poppy seed, whatever. You totally don't notice you have it. But sometimes they can be as big as like grapefruits or even bigger. Grapefruits? Grapefruits, yes. That sounds uncomfortable. Yes. And sometimes you have one, but sometimes you have many. And by the time you are a woman who's 50 years old, about 80 % of us have these. And the number is higher for African-American women than it is for Caucasian-American women. But yeah, these are very common. And so when you say they're benign, they're not cancerous. I understand cancer is sort of like a category.
56:44It's not a single pathology. And it has to do with cells growing out of control. And so here we have cells that seem to be growing kind of out of control. What makes them non-cancerous? So one, they're not going to metastasize. And two, so I am not a cancer doctor. I'm guessing that a part of the issue is that if you have uncontrolled growth in something like your liver, it is likely to cause problems that could kill you. Whereas if you have uncontrolled growth in your uterus, most of the time it's not going to cause problems. So a lot of us who have fibroids experience no problems from it. And so, you know, it might be interesting to have a cancer doctor, an oncologist on the show at some point.
57:24But to me, what's important is that one, it's not metastasizing and two, it's probably not going to cause like a life threatening illness. It does sometimes cause problems. So if it gets too big, then it can, for example, push against your rectum and cause issues with constipation or it can push against your bladder and cause issues with urination. In very rare instances, it can cause infertility issues. I hear that that's not very common, but it does happen sometimes. It can increase period bleeding or increase the frequency of bleeding in between periods. And so some of these things are things where you can be like, well, that's annoying.
58:01I can ignore it. And then some of those are problems where you're like, I absolutely need to deal with this. And so this sounds like it's never good, but it's not always bad. It's just sometimes uncomfortable or there are some other issues. But if a lot of women have this, like 70 to 80 percent, then like, is there some benefit to them? Is there some reason we have them? Yeah. So as far as I can tell from my research, I have never found a benefit. So I think what's happening is that in the uterus, you have a lot of cells that have receptors for estrogen and progesterone. So these are hormones that we think of as being important for females.
58:37They're important for maintaining your menstrual cycle, your estrus cycle. So maintaining like the cycle of things that happen to the female body every month. And one of the things that your uterus does is at certain times of the month, it produces a lot of uterine lining where, you know, eggs can implant in this. And then it releases all of that once a month during your period. And so you have cells that are used to getting the message that it's time to reproduce, reproduce, reproduce, reproduce, make a lot more of me. And then they also get messages that it's time to stop doing that. And so I think what's happening is that some of these cells get the message that it's time to start replicating and they replicate a little bit out of control.
59:16and that might explain why this is a problem that is typically not experienced until after you get your first period and stops being a problem after menopause because your body stops like producing a lot of estrogen, for example, to induce these cycles. So is this something people have been dealing with like throughout all of human history? Do we have like records of it from ancient Egypt and stuff? Ah, okay. Yeah. So I did not come across records of it from ancient Egypt. It is possible that this is a problem that we are dealing with more now because a lot of the risk factors for getting this are things that happen more in our modern life.
59:55So for example, if you have a higher body mass index, you are more likely to have fibroids and higher body mass indices were probably not a thing that was happening to our species thousands of years ago when food was much harder to come by, but is more common for people to be experiencing now. Earlier onset of menstruation, so the age that you get your first period as a predictor. And if you get your first period sooner, you're more likely to experience fibroids. And over time, young girls have been getting their periods earlier and earlier. So that might contribute to why we're seeing this in a lot of women.
1:00:33Late age for menopause is a contributor. But then there's also some like quintessential, quote, modern life issues that might be at play here. And one of them is that a lot of the stuff that we put into plastics has chemicals in it that mimic things like estrogen. And so it's possible that our estrogen receptors are getting bound by stuff more often and are getting the message, hey, replicate, replicate, replicate more often than they did in the past because our environments are now sort of inundated by these chemicals that look like hormones but are not things that were made by our body to actually send a message about something that should happen.
1:01:10So as far as I can tell, there's not a benefit to fibroids. for most women, having fibroids is not a problem. You may not even notice you have them. You may never have to get treatment for them. If you do need to get treatment, sometimes those treatments are things like, hey, I'm going to take some pain medications because I feel a little uncomfortable. Or maybe they are like birth control pills to help deal with the problems of excess bleeding. Sometimes it'll be a surgery if the fibroid is big enough and it needs to be removed because it's causing problems. And in very extreme cases, you might end up wanting to get a hysterectomy where you essentially take out your whole uterus so you don't have to deal with the problem anymore.
1:01:49But that means you can't have children anymore. So that's a pretty extreme option that a lot of folks decide to not go with unless they are done with their uterus and are ready to yeet it into the sun. And I'm getting close. And has there been enough science about this? Have we studied this as well as we need to? No. No, we have not. Yes, right. So the last part of the question is why don't we know more about this? And the answer, unfortunately, is that women's health problems are very understudied. In fact, in general, when you study medical issues, it's much more likely that men are part of the experiment relative to women.
1:02:25For a long time, women were thought of as something like a complicating factor. Let's just study it in men so we don't have to worry about the fact that women have cycles that, you know, change over the course of the month and we'd have to like control for that. And then sometimes women might be pregnant. So we don't want to be like testing drugs on them because, you know, what if we end up messing with the fetus in some way? And so for a variety of reasons, some of them nice, like trying to make sure that fetuses don't get exposed to chemicals we don't intend to expose them to. And some of them just sort of overlooking women in general, which is not so nice, is how we got to this place today.
1:02:58And so if I can make a book recommendation, Invisible Women, Data Bias in a World Designed for Men by Caroline Criado Perez. This is a great book that goes through a variety of different places where data has essentially been collected for men. And the thought that data on men will tell us everything we need to know about humans in general and how this has sort of harmed women in a variety of ways. And she has a great chapter on how this has impacted women in medical settings, which is where I learned, you know, that we are often even today, even today, when you do rodent studies, they're more often done on male rodents.
1:03:31Sometimes even when they're related to questions about female reproductive health, you'll do them on male rodents. And so anyway, totally blows my mind. This book won the Royal Society Science Book Prize. And so it's got, you know, like the science. And only the best books win that prize. Oh, that's not what I was going for. But thanks for saying it. But anyway, so yeah, in a lot of domains, women are simply understudied relative to men, and that includes medical research. And so we don't know a lot about this issue that affects something like 80 percent of women around my age and a little bit older.
1:04:03So I'm sorry to be giving sort of a sad answer, but I think that's exactly what the listener expected when they sent this question. And let's go ahead and hear what Xenia has to say. Hello again, Daniel and Kelly. thank you for looking into my question about fibroids thank you for the book recommendation i will look into that but yes it's more or less what i expected we don't know so much we haven't done much research so i just try to stay positive that we can talk about this problem and that there are gofundme campaigns and stuff like that to try and collect money to do more research for instance there's the project called Make Fibroids Count.
1:04:48I was curious to hear that there has been an earlier onset of the first period for young women. I wonder if that is also tied to modern lifestyle or if there's some other reason for that. Yeah, thanks a lot. Your podcast keeps me thinking and challenging my ideas about the world. So please keep it up. Thank you. Bye. All right. Thank you so much to everybody who sent questions in to us. If you have a question, you can shoot it our way at questions at danielandkelly.org. Or you can join us on Discord and share your questions with the Discord community. Even if your name is not Zach, you are very welcome to send us a question.
1:05:34Even particularly if your name is not Zach. We answer every question and some of them end up on the show. Write to us. We'd love to hear from you. Until next time.
1:05:51Thanks, everybody, for listening. Please go and do us a favor and rate the show on whatever podcast app you're using. It really helps people find us. Daniel and Kelly's Extraordinary Universe is edited by the amazing Matt Kesselman. He really is a wizard. You can also find us online on Blue Sky, Instagram, and XDNKUniverse. Come engage with us. You can email us at questions at danielandkelly.org. We really do want to hear from you. And you can find our website, www.danielandkelly.org, where you'll also find an invitation to join our Discord, where everybody comes and talks about the amazing universe.
1:06:31And we also have the most amazing moderators. This is an iHeart Podcast. Thanks for joining us. When Democrats are messing up, I say it. When Republicans are messing up, I say it. I'm Essie Kupp, a journalist and political commentator. And on my podcast, Off the Cup, I help you make sense of the often nonsensical news. I do this on cable news too, but on my podcast, I can really let loose and be my honest, unfiltered self. I just want to talk about something that happened this week because it's so bonkers. So stupid. Such incredibly bad politics. We have to talk about it. Come for the hot takes.
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From the publisher
Daniel and Kelly answer listener questions about tick-induced meat allergies, experiencing quantum effects, and fibroids.
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