Podcast · 13 episodes
Lifespan with Dr. David Sinclair
by Lifespan Communications LLC · English
Lifespan with Dr. David Sinclair is a health and science show on how to live longer and stay healthier - grounded in the latest longevity research. A Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, Dr. Sinclair breaks down the latest studies into clear, applicable insights so that you can perform at your best and live your longest, healthiest life. Season 1 ranked #1 in Health & Wellness podcasts. Season 2 is now live, starting with two Rewind episodes, followed by new episodes detailing the latest breakthroughs in aging science. Become a Lifespan member at lifespan.com. New episodes every two weeks.
Latest episodes
This Sugar Substitute May Extend Your Life | Lifespan with Dr. David Sinclair - S2, Ep. 9The episode argues that glycine (a simple amino acid, also used as a sweetener) may improve healthspan and potentially extend lifespan, possibly by mimicking methionine restriction.19 Sep 2026 · 49 min
This Sugar Substitute May Extend Your Life | Lifespan with Dr. David Sinclair - S2, Ep. 10Why physical activity extends lifespan, focusing on biology (repair vs “abundance mode”), evolutionary mismatch from modern sitting, and practical exercise “dose” (consistency over extremes).19 Sep 2026 · 1 h 11 min
How to Eat for Gut Health & Longevity | Lifespan with Dr. David Sinclair - S2, Ep. 8How diet affects inflammation, glycation (sugar attaching to proteins), gut microbiome balance, and nutrient-sensing pathways (mTOR, AMPK, sirtuins) that influence aging and longevity.11 Sep 2026 · 31 min
All episodes
This Sugar Substitute May Extend Your Life | Lifespan with Dr. David Sinclair - S2, Ep. 9The episode argues that glycine (a simple amino acid, also used as a sweetener) may improve healthspan and potentially extend lifespan, possibly by mimicking methionine restriction.19 Sep 2026 · 49 min · 24 chapters
This Sugar Substitute May Extend Your Life | Lifespan with Dr. David Sinclair - S2, Ep. 10Why physical activity extends lifespan, focusing on biology (repair vs “abundance mode”), evolutionary mismatch from modern sitting, and practical exercise “dose” (consistency over extremes).19 Sep 2026 · 1 h 11 min · 31 chapters
How to Eat for Gut Health & Longevity | Lifespan with Dr. David Sinclair - S2, Ep. 8How diet affects inflammation, glycation (sugar attaching to proteins), gut microbiome balance, and nutrient-sensing pathways (mTOR, AMPK, sirtuins) that influence aging and longevity.11 Sep 2026 · 31 min · 14 chapters
Why We Age | Lifespan with Dr. David Sinclair - S2, Ep. 7Biological aging begins before birth and continues daily; chronological age doesn’t predict biological age.4 Sep 2026 · 31 min · 18 chapters
Why Exercise Slows Aging | Lifespan with Dr. David SinclairWhy physical activity slows aging and reduces mortality, including how inactivity shifts biology into “abundance mode,” how exercise triggers repair/survival pathways, and why sitting is not fully…21 Aug 2026 · 1 h 11 min · 27 chapters
How to Exercise to Live Longer | Lifespan with Dr. David Sinclair - S2, Ep. 5How to exercise for longevity—what kinds (cardio, strength, balance), how much (near-maximum benefits at 2.5–5 hrs vigorous/week or 5–10 hrs moderate), and how to tailor timing and recovery.7 Aug 2026 · 1 h 9 min · 28 chapters
Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4The episode explains why vision loss is an early, measurable sign of aging, and describes Dr. David Sinclair’s lab work on epigenetic reprogramming to restore sight.23 Jul 2026 · 1 h 12 min · 35 chapters
What to Eat & When to Eat for Longevity: New Science | Lifespan with Dr. David Sinclair - S2, Ep. 3Practical guide to calorie restriction and fasting for longevity, emphasizing chrononutrition (meal timing), time-restricted eating windows, and prolonged fasting mechanisms (autophagy, ketosis).10 Jul 2026 · 1 h 8 min · 28 chapters
Fasting as a Path to Longevity: The Facts | Lifespan with Dr. David Sinclair - Season 2, Episode 2Fasting and caloric restriction (especially eating less often and time-restricted eating) as evidence-based ways to slow biological aging and reduce age-related disease risk, plus how modern food…25 Jun 2026 · 1 h 15 min · 41 chapters
The Longevity Revolution Is Here | Lifespan with Dr. David Sinclair - Season 2, Episode 1Season 2 premiere of Lifespan with Dr. David Sinclair. It argues aging is primarily loss of epigenetic “information” (cellular identity instructions), and that epigenetic reprogramming could reset…11 Jun 2026 · 1 h 6 min · 28 chapters
The Most Surprising Longevity Discoveries | Lifespan with Dr. David Sinclair Rewind“Rewind” episode revisiting Dr. David Sinclair’s most surprising longevity findings from Season 1—aging as a measurable, controllable biological process; longevity pathways (sirtuins, mTOR, AMPK);…21 May 2026 · 1 h 16 min · 39 chapters
Season 2 Official Trailer: Lifespan with Dr. David SinclairSeason 2 trailer for Lifespan, centered on the idea that “biological age” predicts lifespan and healthspan, and that aging can be slowed or reversed by targeting underlying mechanisms rather than…18 May 2026 · 2 min
What To Do For Longevity | Lifespan with Dr. David Sinclair RewindHow to live longer and healthier via time-restricted eating, glucose and protein management, exercise, and “adversity mimetics” (cold/heat/sauna), plus a longevity supplement stack and…6 May 2026 · 59 min · 30 chapters