#958 - Dr Daniel Amen - The 11 Risk Factors That Are Destroying Your Brain

30:37And stepping into your world for a moment, what is the contrast that's used in certain types of CT scans for the brain? So we don't do CT. No, but what is it for the ones that do get done? Is it MRI? Is it bromine? Bremeline? Catalineum. Catalineum, thank you. For MRIs, which is a metal, which sort of sticks around. Yes. So if you can do it without contrast, ours, we don't use a dye. we use radiopharmaceutical HMPA or serotech and it's gone in 24 hours. And if you drink 32 ounces of water dramatically gets rid of it faster. Gatlinium was something that's Dr. Gabriel Lyne, who's my doctor, brought up.

31:23I was going to go and get a scantum with contrast. And as I'm on my way in, I get a call, like do not get the contrast, please, that's just do it without you'll be fine. etc etc. And yet, while the additives that are used to try and facilitate something that's supposed to make you better, not even the treatment itself is the issue. It's some weird unsilary part of the process. It's the general anesthetic. It's the gadolinium in order to be able to get the contrast. It takes ages for you to work that out. Right. M. M. Mines. Other toxins, the products you put on your body, the parabens, the thalates, what are they?

32:03They're hormone disruptors. And is there a connection between autism and the products we put on our bodies? I mean, I think it's an important question to ask why you see any evidence around that? I have. And it's frightening because many Many people read food labels and it's like, oh, I don't know what that is. I won't eat it, but they never read product labels. And so look at there's an app I like called Think Dirty, which allows, it's not what you think. How is going to say that doesn't sound like something that allows you to scan your personal products and it'll tell you on a scale of one to 10, how quickly they're killing you.

32:54So, for example, I used to shave with barbersol and one is live a long time, ten is die early, it's a nine. And now I shave with something called kiss my face and it's a two and it's actually not more expensive because it lasts forever.

33:18What you put on your skin goes in your body and affects your body and people just never even think about that. What about environmental toxins and quality mold? Mold is bad for the brain. I'm in a documentary with Dave Asprey called moldy because when I saw his brain for the first time it was mothied and it was terrible, turned out he had mold. And when he got rid of the mold, his brain got better. So mold spent a long time detoxing, last year. He did. Mercury, heavy metals like lead. I often, if I see a toxic brain and they're not drinking or using marijuana, I'm like, why is it toxic? Is it anesthesia?

34:08Is it mold? Is it mercury? Is it lead? And it could be their detoxification pathways just aren't very healthy. And people who take so on as have a lower incidence of Alzheimer's disease in large parakeets is helping the body detoxify itself. That's the T toxins. So the am mental health issues, especially negativity bias, low hope, high amp population, and adverse childhood experiences. We published a huge new study on 7 ,500 patients on how many bad things happen to you growing up and did that happen lasting impact on your brain and it turns out it does. So, have you heard of the ACE questionnaire before?

34:59Yes. So, adverse childhood experiences, zero to ten, physical, emotional, sexual abuse, neglect, witnessing domestic violence, having a parent with a mental health issue, incarceration or addiction. And people score four more, have an increased risk of seven of the top 10 leading causes of death, people who score seven or more die 20 years early. So here we have the inverse of the directional dynamic that we've been talking about. This is something which is going top down. It's something experiential story that you tell yourself a narrative That is now functionally changing the way that the brain works is that current direction that we're into here correct And so the chronic stress causes your emotional brain to become hyperactive where now you're always watching For something bad to happen.

36:01So that's the negativity by so the more A score you have, the higher your A score, the more likely you are to notice the negative. And I actually had a positive training program to teach people to notice what's right. And my wife who has an A score of eight, she's like, this is a dumbest game I've ever seen because she believed noticing the scary people protected her. where I'm like the chronic stress is gonna take you out early. But she's like holding on to safety. It feels like safety. Yeah, yeah. In fact, we just did a whole podcast together on negativity bias. And I'm like, you have to teach people to be more positive in order to feel it yourself.

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38:02Yes, absolutely. Is it required dose as a child less than it is as an adult for chronic stress? The dose would be less for a child because they have an undeveloped nervous system. But I often say it's the brain you bring into trauma, physical or emotional, that determines the brain that comes out of trauma. How far to at least the ground that we're working with here. My first published paper a long time ago, 43 years ago, was on post -vead non -stress disorder, and I called it a metaphor for current and past life events. So if you brought a vulnerable brain into a traumatic situation in Vietnam, it's gonna affect you more than if you brought in a healthy brain.

38:56This has been shown, I think in PTSD, across a lot of different studies that I've seen where people who had a predisposition to anxiety disorder going in are the ones that are the most likely to then suffer with the PTSD on the other side. So I guess that would be the brain that you bring in is what you get out on the other end as well. And it's also the genes you bring in because we have seen that genes can affect generation. So if you have PTSD, if your grandparents had PTSD, you are more likely to develop it yourself because that stress changed their genes, the ones they gave to you. Well, I mean, there's a, you know, if you are a woman, at one point, your grandmother was pregnant with your mother, and inside of your mother, while your grandmother was pregnant with her, was the egg that was going to make you, because every baby is born, female baby is born with all of the eggs that she's ever gonna have.

39:54So you have this odd three -generation window, where, you know, month eight, month nine, everybody's together, kind of, in a way. And so that's exactly right and teenage girls need to know they are carrying their babies. And so the drugs they're using is turning on or off certain genes to make illness more or less likely, not in them, but in their babies and their grand babies. And another new study that just like exploded my mind, they looked at Aspartame. So the sweetener that's in diet sodas, it made the mice anxious, but it also made their babies anxious and their grand babies anxious. And the Aspartame is now in 5 ,000 products.

40:48And so you wonder in part if the mental health epidemic is because of an artificial sweetener that people thought was free. Like I used to drink it like it was my best friend because I'm like, oh it's free. And when I was 35 I had arthritis. Like I couldn't get off the floor and I was playing with my kids, my hands, and my knees hurt. And then one of my patients one day, this is how I learn most of what I know. my patients teach me. She said, I stopped aspartame and my arthritis went away. And I think maybe I had a diet soda in my office while she was saying this. So I stopped and my arthritis went away.

41:31And I'm not that smart. And so a month later, I'm like, nah, probably not. So I had another one and I just had this huge flare and I'm like breaking up with diet soda. M -I. M -I is next. What's I? Immunity and infections. And I think there's going to be a whole sub branch of psychiatry in the future. If you overlay a map of schizophrenia, so one of the most severe psychiatric disorders where people who lose touch with what's real and what's not real. Highest insincency United States is the northeast, the North Mid West, and the West Coast. If you overlay that map with the highest incidence of Lyme disease, they're identical.

42:23So is it possible that an infectious disease is causing some mental illness? And the answer is absolutely yes. And we have so many great stories of people like Adriana, 16 years old, beautiful, normal, ghosty, a semidion vacation. When they get to their cabin, they're surrounded by six deer and they think it's a magical moment. And 10 days later, she starts hallucinating. She becomes aggressive. Paranoid goes to psychiatric hospital. She's diagnosed with schizophrenia, put on medication. the doctor trained at Stanford said to the mother, she's gonna have to be on this for the rest of her life.

43:08And six months later, she's a shell of herself. She comes to see us, her brain's on fire, why is her brain on fire? She had Lyme disease. And on an antibiotic, she's no longer so. Earlier in the BC, you were all do that to a person, yeah. And we saw that with COVID. COVID causes this inflammatory bomb that goes off in the brain. And we've known that. Well, like syphilis, for example, pretty much made you crazy. You can change the way you think. And when I saw many HIV brains, they're so negatively affected. Now, thank God there's treatment for it. But I think infectious disease is a major cause of psychiatric problems.

43:57What are some of the other common infectious diseases you mentioned, lime, that's pretty common. COVID, everybody at some point was probably exposed to that. What are the other ones? Herpes, Cytome, Megalovirus, and something called pandas. Have you heard of pandas? Pediatric autoimmune neuropsychiatric disorders associated with strep infections. So you know if you get strep throat, you have to treat it. Because if you don't, you can develop some very serious heart problems. Well, about 30 years ago, researchers at the NIH found the same antibodies to strep to the attack your heart, attack your brain.

44:38And they can create new onset OCD, obsessive -compulsive disorder in the brain from an infection, which is why it's important if you have a psychiatric disorder to get the infection and assessed. I had this one boy as a consultant on the movie Concussion with Will Smith about chronic traumatic and cephalopathy for Paul Domencia. And one of the people who was involved in the movie had a nine year old son who was on three psychiatric medications and they said, would you see him? And when I saw his brain, I'm like, he's got an infection. And it turned out he had lime and pandas. and when they were treated, he got so much better.

45:28M -I -N, Neurohormone abnormalities. If your estrogen is not right, you're a woman, your brain's not right. If your progesterone's not right, your brain's not right. Obviously, if your thyroid's not right, your brain's not right. If your testosterone's too low, your brain's not right. And if it's too high, you lose half your net worth and visit your children on the weekends because your libido goes up and your empathy goes down. It's a very bad thing. Yeah. And did you know that if you get a sugar burst, it drops testosterone levels by 25%. So if you share the cheesecake with your partner at the restaurant, no one's getting and dessert when you get home.

46:16Mm. Okay, deep. Diabetes city, probably, well, they're all bad, but this is super bad. So diabetes city is your blood sugar is high and or you're overweight. And both of them are just a disaster for brain function. In fact, if you're overweight or have high blood sugar, you have virtually all of the risk factors. Because you have low blood flow at ages your brain, it creates inflammation, it alters your genes. So maybe not a head injury, but fat stores talks and they give you mental health problems. It ruins your immunity. It takes healthy testosterone and turns it into unhealthy forms of estrogen.

47:07You don't sleep well. How does anyone have a functioning brain in the modern world? Love in your brain. Let's talk to one of my patients who has a miserable failure with for eight years and a wild success the last six. She slums her brain and loves her life because every day she just asks out one simple question what I'm doing today. Good for my brain or bad for it. And if I just stay with what's good and people go, we have a high school course called Brent Thrive by 25 and decreases drug alcohol and tobacco use decreases depression and improve self -esteem. Independent research showed that. And in week four when we it's 12 weeks in week four we go, okay, these are the things to avoid.

47:57In variable 14 year old boy, never girl boy raises his hand and go, how can you have any fun. And we play a game with the kids called Who has more fun? The kid with the good brainer, the kid with the bad brain. Who gets the girl and gets to keep her because he doesn't act like an ass. The kid with the good brainer, the kid with the bad brain, who gets into the college they want to get into, who has the most meaningful long term relationships. It's the person with the good brain. Right? We have to get rid of the notion I need to do something that harms me in order to have fun. Yeah, it's an odd trade.

48:34I think being British, the sort of Larry drinking culture that was very popular. When I was at university, you know, I went to university 2006 and I was there until 2011. And that was like a right of passage. My master's dissertation was the effectiveness of anti -alcohol advertising on students at Newcastle University. Shock horror, it's kind of hard to do. if you're 21 or 22 years old and you're at university at one of the biggest drinking unies in the UK that kind of has pride, I guess, in how hard it goes. That it's very difficult to have that sort of an intervention, really, really tough, that people saw it as a badge of honor.

49:14You know, there's not many things that you bond over how painful they are, but nights out at one of them. So if you were to ring someone and say, hey, Alex, how was the night last night? You go, dude, it was amazing. Josh Needy lost an eye. He goes, that's not typically the sort of review that I get. But it's this odd right of passage badge of honor that people go, that's how heavy it was. It was crazy, you know, like ended up without a toe. That's the situation that people get into. And I suppose, especially guys like Jonathan Height, Gene Twangy, they've got these concerns about slow life strategy about young people being too coddled, this extended adolescence as they call it.

49:58But I do think that there's some advantages to this, which is that people aren't sending it in the way that me and the guys that I went to uni did from the age of 18 to 25, whether that's because they're too nervous to leave the house or because their brains are rattled by Netflix and TikTok. Okay, right, there's a trade -off that's going on here. I'm not saying that it's necessarily netbed, But we've got rid of one of the toxins. I'm actually not a huge fan of sending kids away to school to live with other underdeveloped brains. You know, your brain's not finished. Develop it until you're 25.

50:34And when I was 18, I went in the military because Vietnam was still going on. And thankfully for me, I didn't go to Vietnam. I went to Europe. But for me, it was great because it was structure.

50:52But the brain's just not done until you're 25. Why would you send it away where basically have the people are functional alcoholics and where that's just normal and it can have a negative impact on their brain for the rest of their lives. I'm interested. You mentioned early childhood experiences earlier on. How do early childhood experiences shape the brain? What's going on? It changes it. It actually takes their emotional brain and heightens it so that they're always watching for something bad to happen. We look specifically at how good you are recognizing faces and they're very good at it. And then there's something called non -conscious negativity bias.

51:44Do you recognize happy faces faster or do you recognize negative faces faster? And they're masterful with the negative faces. So they're always out looking at what could hurt them, what's wrong. And that chronic cortisol exposure, distress hormones is just bad for them. and they're more likely to get cancer, they're more likely to get sick. A quick aside, if you haven't been feeling a sharp or energized as you'd like, getting your blood work done is the best place to start, which is why I partnered with Function. They're in lab tests twice a year, that monitor over a hundred biomarkers. They've got a team of expert physicians that then take that data, put it in a simple dashboard and give you insights and actionable recommendations to improve your health and lifespan.

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53:06Yeah, I think in schools we should teach kids to love and care for their brains and we should teach them how to manage their minds So for example, I was 28 years old in my psychiatric residency at the Walter Reed Army Medical Center in Washington DC That's why I did my psychiatric training one of our professors said you have to teach your patients not to believe every stupid thing they think And I'm like, but I believe every stupid thing I think No one had ever taught me, even though I had 25 years of education. No one had ever taught me to question my own thoughts. Like when I get a thought, my wife never listens to me.

53:48To the least go, is that true? And I've written and produced now 19 National Public Television Specials about the brain. And she's listened to every script. But just if I don't question my thoughts, I believe them, even though they're a lie, and then I act as if they're true, which gets me no end of grief. So now I get that thought, and I'm like, well, that's not true. And it just helps me so much to live in truth and live in the moment. How much can that impact from early childhoods be reversed in your experience? so much of it. I dedicated my book The End of Mental Onus to my two nieces, Alizeanomaly.

54:39It's about eight years ago now. Wow. Almost nine years ago they were taken into foster care.

54:55So I in a very stressful environment. So on a scale of zero to ten, how many aces they had nine.

55:06I dedicated the book to them because it's like you don't have to live. That is not going to be your destiny. And by teaching them to not believe every stupid thing they have, to get them the right help. I love a therapy called EMDR, stands for eye movement desensitization and reprocess. You get triggered. Think about it. Go there, right? Don't drink it away. Go there. Get your eyes going back and forth. Tell me what comes up. Tell me what's happening with the MDO. It's calming down that diamond pattern or the trauma pattern in your brain. I published a study on it in police officers who were involved in shootings, they all had that heightened emotional brain and after an average of eight sessions all calmed down.

56:02Now, if you grew up in trauma like these girls did, so they had years of it, it takes more than eight sessions. But that plus learning to kill the ants, the automatic negative thoughts, plus not believing that hot cheetos is a health food. They're just doing amazing. Why is the lateral eye movement nice for the brain? Why do I want to do it? It unlocks the left and it gets the left and right hemispheres to work together to unlock the chronic hyperactivity in those circuits and it calms it down. It's very interesting. It's so funny that moving your eyes is this sort of direct access to the brain.

56:48But it's moving your eyes with... Well, your eyes are the only part of your brain that's uncovered, right? I mean, your eyes are really your breasts rooted out through the front of the face. Right. And... But getting them to go back and forth stimulates the left side and the right side, the left side. So while you bring up that memory, it just tends not to bother you anymore. I had one patient recently. He was on a flight. And when he was landing, he started to panic. And I'm like, great, let's go into it. And it went back to very important memory in childhood that he had completely forgotten about.

57:37And as we processed it, flying didn't bother him anymore. And so I was love. I want my patients to keep track of their triggers. So rather than drink, I want you to be curious about it, not furious. And if you write it down, we'll go hunt it down. I'd heard something similar to EMDR about walks that low commotion with the scenery sort of coming past the eyes and typically as you're walking sort of like left, it's a squirrel over there, looking at this cog coming this way. So have you seen with walks? Is this been shown in the data that you've had a look at? You know, I think that's how Francine Shapiro who developed EMDR noticed on a walk when she would look one way and then the other way, one way, then the other way, whatever was bothering her didn't bother her anymore.

58:29I'm then developed this very cool form of psychotherapy. I also use it for peak performance that I'll use the iMovement, I have an MBA player to like, all right, let's go through the last game where he played really well. And just to sort of lock in that feeling. But if he had a bad game. It's like, well, let's go to all the other bad games that you had to just sort of clean them out of your head and then use it to focus on, so how do you want to show up? I'd heard that once patterns and habits are laid down, that there's no pruning or getting rid of those pathways, all that there is is laying more preferred pathways over the top of them.

59:20How true is that from a structural perspective? Yeah, I don't think it's true. I think I've seen people undergo wildly positive transformations. And wildly negative ones. Right? If we think of neuroplasticity as a good thing, But it's not. It's a thing. Whatever you continually pay attention to, if it's positivity, your brain will learn to be more positive. If it's negativity or an addiction, it's going to be more negativity. And so where you bring your attention repeatedly always determines how you feel. As long as you don't have an infection and your hormones are right, And we didn't talk about S, which is sleep, which is so important because when you sleep seven and a half hours, it turns on 700 health promoting genes.

1:00:21And if you sleep less than six hours, it turns off 700 health promoting genes. So making sleep, like, I don't, I go to bed to wash my brain, right? I go to bed because I want my memory to be better tomorrow. That's why I don't drink because I have more RAM. I have word dreams. Hmm. Imagine for a second that you were to design a protocol for someone to follow that would put that brain in the worst possible state. We want to take a well -functioning brain and we want to make them moody and slow and unable to regulate themselves emotionally. What would be your prescription to turn a healthy functioning brain into a totally useless one?

1:01:01So if I was an evil ruler and I wanted to create mental illness, what would I do? Well, if we just use the Bright Minds acronym, I wouldn't let them move. Right? I give them video games and just go stay here. Don't go anywhere. Stay here. And I'd give them a little bit of alcohol that they could have whenever they wanted in marijuana and caffeine. I wouldn't have them learn anything new. I'm like, now you just do Netflix. and not even let them have the documentaries. I would not encourage them to take care of their teeth and floss. I'd give them a process food diet which increases inflammation.

1:01:50I would tell them, oh, your family's fat, so you're gonna be fat.

1:01:57If you drive, make sure you're texting while you're driving to make sure they get a head injury. I would teach them that alcohol is a health food, and marijuana is innocuous, and yeah, to just go under all the plastic surgery they could to get the genital anesthesia that they didn't need, right, to believe every stupid thing they thought. I'd have them start the day by turning on the news, And because people who watch the news are 27 % less happy in the afternoon if they start the day with the news. And I'd have them never check their vitamin D level, never eat onions, garlic, or mushrooms because they boost your immunity, never check their hormones, eat all the bad food they wanted.

1:02:52and keep them up late at night, like get really interested in murder shows right before bed so they couldn't sleep. And that would take somebody that's relatively well functioning and turn them into somebody who needed to see me. That could actually be a good for an end of the funnel for the marketing though. If you promote that and then you can give them on the other side. Something else that we'd sort of touch down earlier on, let's say that someone's suffering from anxiety. What are the biggest do's and don'ts for them? So, few suffer from anxiety and you start to panic, don't leave the situation you're in because if you leave, the anxiety is going to begin to control you.

1:03:34So, that's the first step. The second thing is when you get anxious, learn how to breathe with your belly. diaphragmatic breathing is as effective as Xanax and there has no side effects. And do what I call it the 15 second breath. And you know what I mean when I say diaphragmatic, when you breathe in, stick your belly out as far as you can, because when you do, there's a muscle between your chest and your abdomen called the diaphragm. And it flattens and it doubles your lung capacity. So most vain people, like they hold their belly in when they're having a picture because they don't want to be seen as fat.

1:04:20But do that when you're taking a picture. But in everyday life, you breathe in, stick your belly out as far as it'll go. Four seconds in, hold it for a second and a half, eight seconds out. So take twice as long to breathe out as you breathe in, hold it out for a little bit. So that's a 15 second breath. It'll break a panic attack and under four or five breaths. It's like so cool. And you're controlling your own physiology. And then write down what you're thinking. And odds are, it's scary thoughts. They don't like me. They're judging me. I'm gonna fail in some way. And I teach all of my patients the 1840 -60 rule that says when you're 18 you worry about what everybody's thinking of you.

1:05:13When you're 40 you don't give a damn about anybody thinks about you. And when you're 60 you realize nobody's been thinking about you at all. People spend their days worrying and thinking about themselves, not you. And then if you need something else to calm down, a huge fan of hypnosis, just masterful of calming anxiety, I like supplements like theonine, GABA, magnesium, ashwaganda, curcumins help actually decrease inflammation. There's so many things, but often people go to the doctor and become really anxious. And they write them a prescription for benzo, which I think should be male practice, because once they start the benzo's anax out of an valium, whatever, they never stop them.

1:06:11And benzos are associated with addiction and dementia. So anything that's associated with addiction and dementia, you should only take that really thoughtfully. If your workouts feel flat, your recovery slow or you've just been feeling off, might not be your training plan or your diet, might be something a bit more boring like a testosterone. So if you're not performing in the gym or the bedroom, the way that you would like, or you just want to improve your testosterone naturally, Tom Katali is a fantastic research -backed place to start and when it's stacked with zinc, this can make a huge improvement to your testosterone production, your strength, your recovery and your energy, which is why and such a massive fan of a momentous zinc, it supports testosterone, boosts vitality and helps keep everything running like it should.

1:06:59And if you're still unsure, Momentus offers a 30 -day money -back guarantee, so you can buy it, use it every single day for 29 days and if you don't love it, they'll give you your money back. Plus, they ship internationally. Right now, you can get 35 % off your first subscription and that 30 -day money -back guarantee by going to the link in the description below by heading to livemomentus .com, Sash Modern Wisdom and using the code ModernWisdom, a checkout. That's L -I -V -E -M -O -M -E -N -T -O -U -S .com, Sash Modern Wisdom and Modern Wisdom. A checkout. I'm interested in why we've got this massive onset of anxiety disorders.

1:07:34It seems to be the emotion to sure of the 21st century. So maybe it's Aspera tame. I mean, it was really clear in this study on animals that they got Aspera tame and they were anxious. And Valium, one of the Benzos, calmed it down. No. It's like, and not only did it make the animals anxious, it made their babies anxious, it made their grandbabies anxious. And that's not the only thing, but if you mix that with all the other ultra -process foods, with social media, with the negative news, right, our polarized culture now, which is quite frankly, it's great for psychiatric business, but it's a disaster for our society.

1:08:23I mean, I had people suicidal after the last presidential election. Did you see that study that was done on the Boston Marathon bombing, where they had two cohorts. One were either runners or spectators at the actual event, and the other were people who had watched at least two hours of news, and the people that watched two hours of news showed more signs of post -traumatic stress disorder than the people who were actually there and observed it firsthand. It's crazy. And it's being done purposefully, right? You watch whether it's Fox or CNN. It's breaking news, breaking news, breaking news. That's the same thing I've been talking about for days.

1:09:04Everything can be breaking news, but apparently it is. But it's to keep your attention so they can sell you more things. And that should make you mad. And I'm very interested in your research when you were studying alcohol prevention, because I'm working with the White House on issues with mental health. And I wrote a drug and alcohol prevention program for them. But it's mostly about getting young people pissed off at Anheuser Bush. Because you know, they spent $7 .2 billion last year on sales and marketing. I'm like, they're not only taking your money, they are taking your life and they're doing it with the lie.

1:09:58And so getting them angry about being manipulated because I think that's what motivates teenagers. It's emotion. And not wanting to be controlled. And often they're like, well, my parents said don't drink. So now I have to - It's a revolutionary. Don't control me. I am going after my own independence and my own identity. Don't tell me what to do. They don't realize it's Anheuser Bush, you're telling them what to do. It's Anheuser Bush and Jack in the Box and McDonald's and the food, they're telling them what to do. And they just don't see it. They don't see the manipulation. Put someone, a model like Charlotte McKinney, in a bikini and have her eat Carl's junior.

1:10:49And you know, she's not eating that food because she'd never look like she did. She does, if she ate that food. And so I think it's motivating them with emotion at the same time teaching them to love their brain. The emotion thing's interesting. That was the one area. My master's dissertation, although very well received by my tutors was largely a massive failure in that each intervention that I tried didn't seem to work in reducing. But one that did interestingly was looking at the externalities of how your behavior affects the people around you. So it was imagining a marketing campaign showing you and your friends having a great night out and someone throws up because they've had too much to drink.

1:11:34But the next morning it showed the shopkeeper that had to go and spray his front step from the vomit that one of your friends had left. It was the grand mar that was woken up in her house and she's already got quite fragile sleep, but because you were being raucous in her front garden at four in the morning, that it disrupted her and it made her feel scared and it made her feel anxious. So it was kind of the same as the classic James Bond torture scene where he's being tortured and he can just take it and I don't care. But then they bring in somebody that he cares about or somebody that he loves and that's when they break.

1:12:03It was this externality that I can kind of handle the costs that I need to pay myself, but being the reason for a cost that somebody else has to pay, kind of a special type of pain, and it seemed like people were. But again, with that, it was emotion. The emotion this time, I think, was guilt. It was shame. It was regret. It was pro -social, which was interesting, because I think alcohol a lot of the time is quite anti -social. But yeah, it's interesting that you aligned something not too dissimilar for young people. You mentioned some supplements there. What I mean, there is an endless list of things that are supposed to improve brain function.

1:12:41What are the ones that are the biggest winners from a supplement perspective? Omega -3 fatty acids help mood, memory, and pain. I love that. My favorite of all of them is saffron. So the spice, the most expensive spice in the world has been shown in 26 randomized controlled trials to be equally effective as antidepressants with fewer to virtually no side effects. What's the mechanism it's working on? It seems to increase multiple neurotransmitters and decrease inflammatory markers. And why I got interested in saffron is around 25 years ago, there was a study showing it helped mood and improve sexual function.

1:13:38And most of the antidepressants I prescribe decreased sexual function. And that was always something that used to really irritate me. I'm going to help your mood and ruin your relationship. And I'm like, no, I don't like that. And so I started paying attention to it and then all this research, brand new study out just last week where they looked at 192 studies on 17 ,000 patients looking at what supplements worked for depression. and they compared him against antidepressants and Safran came out the best alone. Interestingly, when you added zinc to antidepressants, dramatically improve their effectiveness.

1:14:27That's so interesting. When you added curcubans from Tomorak, to antidepressants dramatically increased its effectiveness. And so one of my favorites, saffron zinc and curcumin, for mood. They also found salmone, very effective for pain and mood. I've only heard that used to help you get over MDMA come downs. Again, you can tell I was a clip promoter for a long time. 5HTP. Not as effective in the studies as saffron. I'd like it if I'm trying to specifically boost serotonin and Did you know women have 52 % less serotonin than men? I did not which is why if you make them mad they're never going to forget it Because it stimulates the part of their brain that keeps them stuck Hmm And why women are twice the risk of depression as men predisposition to rumination to being stuck on thought patterns.

1:15:36Okay. So I also have better frontal lobes, though. So I published a study on 46 ,000 brains and looking at differences between male and female brains and women have much better frontal lobe function, which is why they go to jail 14 times less than men. I would imagine the testosterone plays a role there as well. It does, but also the lack of forethought. We're taking behavior. If I do this, I'm more likely to be in a cage than if I don't do that. Okay. Omega -3s, saffron, semi -theanine. Love theanine, especially for anxiety. But it also can help with focus. I like that. I like a good multiple vitamin, especially that has vitamin D because low levels of vitamin D are associated with virtually every bad thing.

1:16:37B6, B12 and folate. Methylated? Or have you not got a preference? Methylated. Yeah. And it's about a third of the population has a folate genetic, me too. And so I take extra methyl folate every day to decrease my homosystem and decrease my risk of heart disease. Let me give you an interesting one for my most recent set of blood tests. My MCV was unusually high. Then I had a test done. My Integynetic profile got done toward the back end of last year. I've got four different polymorphisms that wreck my ability to do B12. So one in the gut, one in the blood, one in the brain, and one in the methylation pathway, something like that.

1:17:27So I've switched to B12 injections to try and bypass all of that. and that made a really big impact. In a matter of seconds in what way? I noticed improved energy was the main thing that I was having these dips in energy throughout the day, especially sort of post -lunch, and then earlier on in an evening. So I'm still working through a bunch of stuff on an evening time, but this made an impact despite the fact that every type of different methylated B12 B6 vitamin under the sun. But when you've got this series of different sort of hurdles that you need to jump over. And when you think it's got to the stage where the size of your red blood cells is actually being manipulated by this, I think, I should probably pay attention to that.

1:18:14Any alcohol? No. Because sometimes I'll give you big red blood cells. One of the first things that I see, but that's not it. What else have we not gone through from that Omega 3's saffron, Sami Ashwagandha. I like Ashwagandha. It actually helps boost testosterone levels and can sort of calm you down. Magnesium, I think. Have you got a preferred type? Depends on what we're using it for. If you're constipated oxide, if you can't sleep, glycinate, It's because you have muscle, twitches, torade. But many people are magnesium deficient. And it's like, let's do the simple things before you go to the psychiatric medications.

1:19:12It doesn't mean you won't use the psychiatric medications, but it shouldn't be the first thing. but most doctors, they get no training and supplements, and so it's the medication that keeps you coming back. You mentioned there about comparison scans between men and women. When you look at men and women in your scans, what are the differences that you see in the brains? Women overall have healthier brains. They have healthier frontal lobes, but their emotional brains are busy, which There's not one society on the faith is the earth where men are primary caretakers for children. So bonding is really important, but that heightened limbic system makes them ruinate more, makes them have a higher tendency to depression.

1:20:04And so exercise boosts serotonin. Bright light therapy, I haven't talked about that. I love bright light therapy like sitting in front of a light box for 20 or 30 minutes. And we got a preferred brand of light books. Well, we make one so it has about blue light and white light. So I like ours, but there are many of them.

1:20:28It's been shown to help with pain, with mood, with energy, with memory and sleep. And so too often, you know, we're not in the sun enough. And we've been made afraid of the sun. So I think everybody should know their important numbers, and one of them is their vitamin D level. Normal is between 30 and 100. People who are over 40 have half the risk of cancer of those who are under 20. And when I first tested mine, when I learned about this 15 years ago, I was 17. And I live in Southern California where the sun is out mostly, but I'm working during the day. And I noticed when I got my level high normal, 80, my appetite went away.

1:21:22Like I'd been trying to lose that extra 20 pounds forever, but it was the food chatter. Always the food chatter just went away because my vitamin D level was normal. Is that just crazy? Like things you wouldn't even think about. Well, it's a system that is not compartmentalized and everything is affecting everything else. And I suppose as well, there's so many different contributing factors that you don't know exactly how it's going to impact you. low level of vitamin D for somebody else could cause them to tend toward depression, could cause them to have lower energy, whatever it might be, but for you it was apt to, all right, so that's women, what about men, under the scans?

1:22:08Lower prefernal cortex function, which is why men are diagnosed with ADD five times more than women, plus they play things like football and soccer, drink more. But they had more activity in the back part of their cerebellum, which is involved with coordination and tracking. Men tend to be really good with narrow focus. Women with vision better peripheral vision, which means, I hate this part, if a guy sees a really cute girl, he has to turn his head, so he gets caught. If a girl sees a really cute person, they don't have to turn their head, so they don't get caught. It's sort of unfair. Very interesting.

1:22:58My favorite study around local spatialization versus what's it called when you throw something through the air and it intersects with something else. Anyway, the visual spatial coordination. Thank you. So, this would never be done again, I don't think. But it was in the 70s or the 80s. One of the problems that you have when trying to do these sorts of studies is that male shoulder articulation works differently. You've got different lengths in the forearm. So, if you're going to say, well, look at throwing velocity, look at throwing accuracy. You've just been trained to throw stuff. You put a group of boys near a field that's got some rocks in it and those rocks are inevitably going to end up in the air pretty quickly.

1:23:42That's not quite the same for girls. So anyway, they decided to let their pride alone talk back part of their brain. It's stronger. We did see that on males. Yes. The study that they did to try and reverse this or at least to try and control for the ability to throw the training, the articulation, the length of the forum, all these sort of stuff. They took one of those tennis balls serving machines and they fired it at students and it was the job of the students to just get out of the way as opposed to try and hit something they just needed to avoid it and they didn't hit any one of the male participants once, whereas I think the girls got peppered a little bit more.

1:24:17Again, not convinced that this would pass an ethics board now, but just really interesting. I'm going to guess that the local memorization stuff, if you put a 10x10 card grid, that women will just wipe the floor with men, typically, with stuff like that. But if you want to try and have a darts player on your team, it's like, lean toward the guy, perhaps, then the girl. Yeah. You've done talking with men and women. You've done a lot of scans of couples in conflict. What have you learned about love and the brain and how we regulate in that? But it's easier to love someone whose brain is reasonably healthy because they're reliable, predictable, and you can trust them.

1:25:03When the brain is not healthy, and then it's like, well, in which ways could it not be healthy if their frontal lobes are low? less predictability, less consistency, more impulsive. And the hippocampus in women is larger than in men, the hippocampus is the major memory structure. In the brain, it gets short term memory and to long term memory. So you're just more likely to say things you shouldn't say. And hurt her feelings and then she won't forget it. She's going to hold onto it. She's going to hold onto it. I often, my first couple, they're so interesting. They brought their two kids to me because I thought they had ADD and the little girl had in a tent of ADD and she got way better when I treated her.

1:26:02The little boy didn't get better. And so I started seeing him in therapy. I'm like, why is he not getting better? And I realized He's not getting better because his parents hate each other. And I was young and bolder than. And so I go to the parents and I'm like, he's struggling because of your stress. I said, why don't you let me see you in therapy and see if I can help you? And they said, Dr. Amen, we really like you. We've seen four other marital therapists and it always makes us worse. And in my head, I thought, well, maybe they just hadn't seen anybody really good. And whenever you have that thought, shut it down.

1:26:44And so they saw me. The first week, I had two couches in my office. They sat on the opposite end of each couch. That's a bad sign in Marital Therapy. And after about three months, I know I'm not going to help them. The woman has a PhD in grudge holding. She is beating things from 15 years ago. She just like loops can't let go. And he's the sniper. I remember thinking, you're the sniper. He'll like, he's late, he's disorganized. But whenever she gets into a vulnerable teaching place, he'll say something so mean to her just to get her going again. And at six months, I start having physical stress symptoms when I know they're on my schedule because I hate being ineffective.

1:27:37At nine months, I'm in the shower getting ready to come to work and I'm like, these people are on my schedule and my stomach starts to hurt. And I'm like, today I'm going to tell them to get divorced because it's not good for children to be in homes with chronic problems. If that's happening to you and you just need to see the monster twice a week, imagine what it's like as a child that lives with them. Oh, it's terrible for them. But I grew up Catholic and my mother was not kidding about the whole thing. And so Catholic, divorce, bad hell, things like that. And so I'm in the shower and the Catholic voice visits me because you're not a good enough therapist.

1:28:15You're going to tell them to get divorced and damn their eternal souls to hell. And I started juggling and I'm looking at the water faucet going, how much therapy do I need to get a ruse? And I got out of the shower and we just started scanning people like that year. And I called my friend who owned the Imaging Center and I'm like, Jack, will you give me two scans for the price of one? Because I was always like negotiating for my patients. And he's like, why? I was like, Jack, I have this couple and I'm failing miserably. He's like, couple. He's like, I've been married twice. I can't figure it out.

1:28:53Do you think this will help? Maybe we could do a business together and call it brainmatch .com, which I thought was hysterical. So I told, I'm like, obviously, I'm not being helpful to you. I want you guys to get scanned because that'll give me more information to help you. She had an area of the brain called the anterior singular gyros from hell. It's the gear shifter in the brain. When it works too hard, people get stuck. They go into loops. things don't go their way they get upset. It goes with an OCD -like brand, and he had really low frontal lobes, which as a child psychiatrist I should have figured out the ADD and the kids came from him.

1:29:39And so I put him on Rettelon, Huron Prozac, and just by random chance, if you believe in random chance, the night before I read an article in the American Journal of Psychiatry, the Prozac comes down to Singular jars. And so I put her on Prozac, Kim on Ritalin. I said, let's try this. I don't wanna see you for a month. Let you see how they met. A month later they come back. They sit on the same couch. She has her hand on his leg. Now that's a good sign and marital therapy. And they learned everything they needed to learn and they didn't need me anymore. 35 years later. No, it's 33 years later, it's given a lecture in San Francisco.

1:30:23They showed up. And they're still buried. And they don't see therapists, and they're not fighting with each other. Are they still on Redland and Prozac? No, they're on different things, supplements, but their brains are balanced. And they love their brain. And they love me. So. Well, you kept them together. And so if you think of domestic violence, think of somebody's had a head injury, or there's a substance and it's in ball control. There's bad brains that are involved in domestic violence. And it could be both. It could be one spouse can't let things go and just hammers the other spouse and then the other spouse because their frontal lobes are low.

1:31:05They can't take it anymore. But when you look at it through the lens of neuroscience, judgment begins to go down and effectiveness goes up. Because it's easier to call people bad. The harder it's those moral claim about whether or not you are doing this thing or not doing this thing, but you wouldn't say the same thing to a dog that was poorly trained and had been abused for its entire life. Yeah, compassion goes way up. Can we rewire ourselves to be better partners? Absolutely. I always start with an exercise called the One Page Marital. One piece of paper right down what you want. Relationships work, money, physical, emotional, spiritual health.

1:31:53What do I want my relationship? Kind, caring, loving, supportive, passionate, relationship. Almost everybody I know wants that. And so if your brain is healthy and you get a rude thought. You don't say it. Like Jerry Seinfeld once said, the brain is a sneaky organ. We all have weird, crazy, stupid, sexual, violent thoughts that nobody should ever hear. But when you drink, they get out. And I have crazy thoughts, but I don't say them. And I question them often. What does sex do to the brain? What does sex, the act of sex do to the brain? I wrote a book once called The Brain in Love and I talked about weird sex, fiends and fetishes and how the arousal template, wherever you were, however old you were when you first got aroused, that's going to plant something in your brain that's going to be very powerful for you and it could be shoes.

1:33:09It could be cows or it could be all sorts of unusual things. Generally sex produces a lot of oxytocin that sort of cuddle connection, but also possessive your mind, your part of my tribe don't let anybody take you from me. I think oxytocin is actually involved in racism and oxytocin dopamine and stimulation and then relaxation. It helps heart rate variability go up. But it depends. There's so much wrapped up into sex about performance, about mutual respect. And I think for people who are thoughtful, it's like, let's have really good communication around this and not get our feelings hurt if I didn't do what you wanted me to do.

1:34:09And I often say, guys have a short attention span. You have to teach them sort of like shooting free throws. You know, how do we learn to shoot free throws? We do a lot of them. And that's a good coach. Notice is what you do right teaches you what you could do better. If we had that sort of mindset with our partners, it would be better. And it's harder today because of pornography. The pornography changes the brain for you have different expectations than perhaps before pornhead was everywhere. Why do you think it is that people struggle to communicate more clearly around sex? Is it shame? Is it embarrassment?

1:34:50Yes, and I think it's a lack of really great education on communication. What role does brain chemistry have in how we choose upon this?

1:35:05Well, I think brain function in our past has a lot to do with how we choose our partners. Are we choosing them because they're really a great partner for us or we're filling a deficit in us? Can you give an example of how that should be? Well, a deficit would be, my brother was a drug addict and tried to kill himself. And I loved him so much that I tend to be attracted to people who are troubled. And there's a part of me that wants to fix my brother. So I try to, so I tolerate and want to fix my partner. the eye can fix the main. Yeah. Which often comes from past trauma. Have you noticed any particular brain patterns in people who struggle with commitment or jealousy or envy in relationship?

1:35:59Well, jealousy, they tend to be hyperfrontal. Though their frontal lobes work too hard, it's like they get a thought in their head and it then starts to spin. And I see that a lot, they can't let go. And some of them become stalkers. I had one patient who was the stalker and she had no CD pattern in her brain. She just couldn't let go.

1:36:28Her brother saw me because he had road rage. Couldn't let it go that someone cut him off. I was just gonna tailgate them. She's gonna stalk the person, he's gonna stalk the car. Yeah, actually got arrested for following somebody eight miles down the freeway and then when he cornered him on an off -ramp, he was an orthopedic surgeon, took out a long metal run, and bashed his windshield in. Called me from jail because I was seeing his sister. He had a very obsessive brain. And she did too, just pointed in a slightly different direction. I learned about limmerance a couple of weeks ago. Have you heard of this term?

1:37:09Limmerance. Now. So it's currently being proposed to be added to the DSM. Imagine a crush, but on steroids, and it never goes away, so that infatuation phase, a lot of rumination, but limmerance in particular is often a unidirectional. So the limmerant, the LO, the object of this person's desires often doesn't even know that they exist. Sometimes it can be for fictional characters, cartoon characters, it can be for movie stars, it can be for people that have never met you. And it's fascinating. And I think that the obsessive, the OCD element of this, finding something, grabbing onto it, getting your hooks in and not being able to let it go, it'll be fascinating for you to look at the brains of people that were literate as it's known, are suffering with the limmerance.

1:37:56That would be interesting. And I would expect there to be hyperfrontal. So what if from our previous conversation, that is strep infection, that activated the obsessive part of the brain? And if you treated that effectively, they stopped the obsession. Like how interesting is that? One of my friends, Jason Waller, he was on a show called The Hills. He and I worked together on our foundation. and he went to 14 alcohol and drug programs, like he was not learning. But as a child, he had terrible OCD. To the point where he'd wear gloves at night with Neosporin in it because he'd washed his hands so often that if he had pandas syndromes, we assume he did, he had pandas syndromes that had caused the OCD, which then caused the drugs in alcohol to calm down his brain.

1:38:57and it all goes back to an infection. So I think this is so interesting, but you brought up the DSM, I'm not a fan of it at all. I don't know anybody that is. Right, diagnostic and statistical manual, a mental disorders. I'm like, they're not mental disorders, they're brain disorders, get your brain healthy and your mind will follow. Stop making diagnoses based on symptom clusters, we know biological data. That's the dark ages. Yeah, we need to bring it into the light. You've worked with, you mentioned celebrity, you've worked with a lot of celebrities. What do you wish more people knew about the reality of the lives of high status people?

1:39:43Well, they're like regular people except their dopamine has been worn out that fame is potentially lethal for the brain. When people adore you, want to be with you, want something from you that they don't have the skill. It takes often to manage it. You can't, like I've seen some of the world's most famous people, and they all have this thought, I'm not enough. And I look at them like, if you're not enough, it would ever be enough. Right? But when you give them the tools and they like use them dramatically better. Some of the just the most wonderful people. I just did Chloe Kardashians follow up scan.

1:40:36I scanned her for their show two and a half, three years ago. It was not good because she was in a bad car accident. But she just did what I asked her to do. and her brain's so much better. Oh, that's so bad. She changed how is that manifested in her daily experience? What's different for her? She's just happier and more consistent and making better choices. We've talked a lot about supplement side, some of the ways you can get stuff wrong. What are the daily habits that offer the highest ROI when it comes to improving brain health? Well, so if you gang go back to bright minds, blood flow, it's exercise, walk like you're late, coordination exercises, or the best, played table tennis with my grandkids yesterday.

1:41:22That's the best brain exercise. Table tennis is great. Table tennis. Got to get your eyes, hands, and feet all working together while you think about this spin. Not to pick a ball, is that okay? Pick a ball, but pick a ball is not as fast. Bing pong is much faster if you play at a high level. Retirement in agent is just new learning. Always push your brain to do and learn something new. Inflammation floss and take omega -3 fatty acids, genetics, know what's in your family and be on that prevention program. Every day of your life, if you have addiction, be on an addiction prevention program, if prevention program.

1:42:07Head trauma, don't text while you drive. Don't let your kids play tackle football or hit soccer balls with their head. Toxins, suboid exposures, much as you can and detoxify. What are the detox, drink more water because you'll pee out the toxins and eat more fiber. You'll excrete the toxins, so on as sweating with exercise. Stop the alcohol because it ruins your detoxification organ. Mental health, stop believing, never stupid thing you think. Start every day with today is going to be a great day. And every day, my favorite exercise went well today. Just go hour by hour looking for what you love.

1:42:54One of my patients this morning told me a dream that I'll just never forget because it just shows our work has gotten into his unconscious dream life, which made me so happy. Um, our interview, the show up tonight, um, and what went well today. Um, I know your vitamin D level and I take something called smart mushrooms every day because mushrooms are good for immunity. Uh, neurohormones kill the sugar because you want your testosterone to be healthy, diabesity. I know how many calories I did. I, because I have obesity in my family, and if I ate too much, weight just loves me. I'm wants to stay, and I don't want it to stay.

1:43:40And I go to bed early every night. My kids make fun of me. Like, say, 30. I'm going to go get ready for bed. And it's like, but I'm like, I want to feel good tomorrow. Right? So it's thinking not just about the moment, but thinking about all the moments, including death. It's like, okay, so we're all going to die. What's going to happen between now and then? So I'm not going to encourage it. But I'm also not going to be weird about it because I don't believe we're on the planet by random chance. I think there's creative design to think we're having this conversation and it was an explosion a long time ago and there was no design.

1:44:21I think that actually takes more faith personally. So I'm like, yeah, it's all going to be okay. We've talked about the ants. How do you advise somebody to bring more positive thinking into their life? They've got a very overactive critical in a voice. They're noticing negative stuff all the time. They've got this default to pessimism, to rumination. Where'd you get them to so that they're more optimistic? Give your mind a name. So I'd love that so much on our podcast, interviewed Stephen Hayes, who developed a form of therapy called Act, Acceptance and Commitment Therapy. And he talked about, give your mind a name.

1:45:06Like, what would I name my mind? Came to me immediately when I was 16, I had a pet raccoon. and I loved her and her name was Hermi and Hermi was just like my mind. She's a troublemaker. She'd teepee'd my mom's bathroom one day, very bad, very bad day. She ate all the fish out of my sister's aquarium. She'd leave raccoon poo in my shoe. That's my mind. It just creates trouble. And so when my mind is sort of getting out of control, you're going in the cage or now I put her on her back and play with their metaphorically in my mind, right? Don't believe every stupid thing. You think, separate, gain psychological distance from the noise, and then train it.

1:45:53Today is going to be a great day. What went well today? And then throughout the day, look for the little miracles. What are the micro moments. And for me, it's a hummingbird. As frayvaries of love hummingbirds, or butterfly, or call from my granddaughter, or waking up next to my wife and describing her hand. Notice it, right? You have to train it. If you just wake up with the news and you tend to be negative, you're just noticing what's wrong and you're going to be miserable. I love Rick Hansen's work around that in hardwiring happiness. It's effortful. I think this is the difference when if you pivot from trying traditional talk therapy to doing something like CBT or something like ACT, you go from something that during the moment feels very active to a modality that during the moment is instructive when you get off the cushion with talk therapy, sometimes there's not that much to do.

1:46:58But when you get off the cushion with CBT or with ACT, that's sort of when the real homework begins and throughout the day you've got, you know, a million reminders on your phone popping up telling you like, what's going well right now, what would you tomorrow want you today to do, what went well today? It's an interesting pivot from investigating yourself to trying to change yourself, I think with that. It's a skill and it's easier to do if your brain works right. Dr. Daniel Aiman, ladies and gentlemen, I love your work. I think it's so fantastic to try and take the onus off of you are broken.

1:47:37You don't have sufficient willpower. You don't want yourself to be better. There's some sort of moral judgment on you as a person because you are not where you want to be. to actually, well, let's see what's underneath the hood. Let's see sort of what's contributing to this. So where should people go? They're going on a keep up to date with all of the things that you've got going on. You know, I often say don't take broken people and put them back together. So I take awesome people and help them be more awesome. And with a better brain, it's easier to do that. They can learn more about our work at aimanclinics .com.

1:48:07Aiman like the last word in a prayer. Aimanclinics .com, they can follow me on Instagram or TikTok, DocAmen, or learn about our supplements at brainmd .com. Thank you. I appreciate you. Thank you.