How to Eat to Live Longer in 2024 w/ Dr. Helen Messier | EP #76

7 Dec 2023 · 1 h 4 min

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Episode Summary: How to Eat to Live Longer in 2024 w/ Dr. Helen Messier | EP #76

Podcast Title: Moonshots with Peter Diamandis Host: Peter Diamandis Guest: Dr. Helen Messier Episode Description: Aging is one of the greatest challenges to human health. This episode discusses the importance of diet in extending a healthy lifespan.

Key Concepts

  1. Introduction to the Healthspan Revolution
  2. XPRIZE Healthspan: A global competition with a prize of $101 million aimed at revolutionizing the approach to aging. The goal is to improve health before biological aging leads to chronic diseases.
  1. The Importance of Diet for Longevity
  2. Diet as a Key Factor: The food we consume significantly impacts our healthspan—the period of life spent in good health.
  3. Balancing Diet: There is no one-size-fits-all diet; dietary needs vary according to genetics, lifestyle, and life stage.
  1. Healthspan vs. Lifespan
  2. Lifespan: The total duration of life; simply being alive.
  3. Healthspan: The length of time one remains healthy and functional, free from chronic diseases.

Key Discussions

Reversing the Signs of Aging

  • Importance of proactive health management.
  • Discusses the relationship between diet and common chronic diseases associated with aging.

Dietary Recommendations

  • No Universal Diet: There is no single diet suitable for everyone.
  • General principles:
  • Phytonutrients: Essential from plant sources.
  • Fiber: Recommended intake is significantly higher than what most people consume.

Absolute Dietary Guidelines

  • Minimize Sugar Intake: Described as a poison; sugar spikes blood glucose and contributes to chronic diseases.
  • Whole Plant Diet: Emphasis on eating whole, minimally processed plants. This includes:
  • High fiber foods to support gut health.
  • Foods rich in phytonutrients and antioxidants.

Nutrient Timing and Moderation

  • Eating Order: Consume vegetables first to control sugar absorption.
  • Hydration: Importance of adequate water intake and recognizing thirst.

Mindful Eating

  • Parasympathetic State: The importance of being calm while eating to enhance digestion and nutrient absorption.

Protein and Fasting

  • Protein Needs: Essential for muscle mass and overall health, with a recommended intake of 0.8 to 1 gram per pound of body weight.
  • Intermittent Fasting: Discussed as a controversial topic; insights on its role in weight loss and metabolic health.

Key Takeaways

  • Food Choices Matter: What, when, and how you eat can significantly influence your healthspan.
  • Cognitive and Physical Health: Maintaining a balanced diet is crucial for preventing chronic diseases and ensuring a healthier life as you age.
  • Community Support: Engaging in group challenges (like sugar-free diets) can help in achieving dietary changes more effectively.

Resources Mentioned

  • [XPRIZE Healthspan](https://www.xprize.org/prizes/healthspan)
  • [Fountain Life](https://fountainlife.com/)
  • [ProLon Fasting Nutrition Program](https://prolonlife.com/MOONSHOT)
  • [Seed's DS-01 Daily Synbiotic](https://seed.com/moonshots)

Conclusion In this episode, Peter Diamandis and Dr. Helen Messier provide actionable insights for listeners aiming to optimize their diets to live longer, healthier lives. Emphasizing dietary variety, mindfulness, and the importance of nutrition, they outline practical steps for embracing a healthier lifestyle in 2024 and beyond.

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Transcript

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0:00I'm NFL Lineback at Tijayawatt and this is my personal best. YPB by Abercrombie is the active wearer I'm always wearing. That's why I reached out to co -design their latest drop. I work with designers to create high -performance active wear that holds up to my toughest workouts. Shop YPB by Abercrombie in -store online and in the app. Because your personal best is greater than anything.

0:31When did making plans get this complicated? It's time to streamline with WhatsApp. The secure messaging app that brings the whole group together, use polls to settle dinner plans, send event invites and pin messages so no one forgets mom's 60th and never miss a meme or milestone. All protected with end -to -end encryption. It's time for WhatsApp. Message privately with everyone. Learn more at WhatsApp .com. One of the keys of diet is variety.

1:04What are your thoughts on sodas? I would say don't. Fruit juices. The same thing. Alcohol. There's really no benefit from alcohol. Okay. What should I eat? Is there one diet for everybody? There is no one right diet for everybody. And there's no one right diet for everybody at all stages of their life. One of the things that plants have in the only place we can get it is fiber. Typically, the USDA recommends 35 grams a day for people. Most of us get around 5 or 10. Wow. We don't get nearly enough. I can't think of anything more valuable than your health. And it's no longer something that's just for the wealthy, just for the elite.

1:47It's something that all of us can be thinking about. I think it's one of the single most important things that you can do.

1:55Everybody, Peter here. This episode is sponsored by X -Prize. Imagine a future where aging brings more time with your family and friends, opportunities for continued learning, second or third careers, and actually allows you to fulfill your entire bucket list and go for a second one. A future where healthy aging is not a luxury, but a necessity. We designed X -Prize Health Span to make that future a reality. X -Prize Health Span is the world's largest health prize. In fact, it's the largest prize on the planet. It's a seven year, $101 million global competition that incentivizes teams develop and test therapeutics that target the biology of aging to improve function and extend your healthy lifespan.

2:42Now, here's the details on the prize. This radical collaborative effort is gonna bring together top scientists, clinicians, policy makers, industry experts, nonprofits profits to create a future where aging is something that we're not scared about because we're making a hundred years old and you're 60, we're adding decades onto our health span. So if you'd like to be involved, please join the conversation by following XPRIZE on YouTube, Instagram, LinkedIn, Facebook, on X and Discord. We're going to xprice .org and learn more about XPRIZE health span. I cannot tell you how pumped I am about this competition.

3:21Going to space has been something I wanted to do since a kid, X Prize has really opened up the doors and living to 120 in a helpful fashion, that's what this X Prize is going to do. Now, back to the episode. Everybody, Peter D. Amanda's here. Welcome to Moon Shots. The Moon Shots conversation we're having today is, how do you add 20 healthy years onto your life? I'm joined by an extraordinary brilliant physician and friend, Dr. Helen Messier. Helen, good to see you. Great to see you, Peter. So excited to be here with you. I just love this stuff, and I can't wait for our conversation. Yeah, no, it's amazing.

4:00And for those who don't know Helen, Helen is the chief medical officer and the chief scientific officer of fountain life. She is very much a renowned functional medicine, thought leader and position. She's founded the National Chain of Concierge Practices in Canada. She's a PhD in molecular immunology and most important, everybody I speak to about her says, oh my god, she's amazing. She's had previous leadership positions at human longevity and biome and so thrilled to have you as part of fountain. So everybody, let me just start by a disclaimer. This is not medical advice. This is advice that you should think about.

4:42Take to your physician if you want to dive deeper. And we're going to be talking about the things you can do today to extend your health span, not just your lifespan, but your health span. And it's no longer something that's just for the wealthy, just for the elite, it's something that all of us can be thinking about. And in a post -COVID world, and in a world where you can do almost anything, I can't think of anything more valuable than your health. I like the saying, your health is your new wealth. So, Helen, where are you today? I am talking to you out of our headquarters in Lake Noenay, in Orlando, Florida.

5:22Yeah, it's super proud. Foundon has four centers today. We're going to be growing towards 30 or 40 centers around the world. But, Helen and I just had a chance to publish a book. It's called Longevity Practical Playbook. And we're going to talk about the things that you can do. And I want to go system by system area by area. This is the stuff that over the last decade I've started to completely shift my life. And one of the things I love about U -Hellen is you not only understand the general elements, but at a molecular or level what's going on. So, let's begin with a topic that is one of the easiest, I think, and lowest cost things people can do to extend their life, which is their diet.

6:20And we are what we eat. Want you to kick us off there when people say, okay, what should I eat? Is there one diet for everybody? Yeah, that is a loaded question because people get very, you know, diet becomes a religion for many people and it becomes very challenging. And I think the first thing to understand is there is no one right diet for everybody and there's no one right diet for everybody at all stages of their life. You know, depending on what they're trying to achieve, depending on your genetic background, I think your dietary needs are going to change over your lifetime. And they're going to be different from your neighbor.

6:59Now, having said that, there are some certain principles that are, I think, the same across most people, you know, getting your phytonutrients from plants, making sure you get enough of your basic nutrients, vitamins, minerals, and so on is critical, making sure you get enough protein for muscle mass and muscle synthesis is critical, making sure you get enough of the healthy fats, because our cell membranes are brain are made up of fats. So everything you're gonna hear me say probably many times through our conversation, Peter, that it's all about balance, right? There's nothing all good or all bad about most things.

7:37It's really getting them in the proper proportions and balance and I think that applies really mostly to food and fatty acids and even the different components of food Omega -3's Omega -6's you know saturated fats nothing was bad if you take it in the right combination and the right amounts you know you said something a minute ago about your genetic background and it's it's very true right, if you're in Laskin Eskimo, the diet your body wants and needs is very different than if you're, you know, of European descent or Asian descent. And there's an interesting fact that was studied and I think is well documented that your longevity outcome.

8:21And let me take a second to define health span versus lifespan for folks who are going to talk about that, right? A lifespan is how long your heart and your brain waves are going. It's like, are you alive with that? I'm your alive. Yeah, it's a zero one. And your health span is how long you feel healthy? How long you're able to play with your grandkids, go up the stairs, walk around, feel cognitively alert? And I think it's health span we're after first and foremost. Yeah, absolutely. You know, and typically if we think of our, you know, if you think of your grandparents and think of aging in our society as it is now, there tends to be this very long, slow decline in terms of our health, right?

9:03We hit a certain age and we tend to get, you can't do quite as much anymore. And over time, we start to accumulate these chronic diseases, we get some diabetes, we get heart disease. And it happens over time and it happens for a long time and we get less and less able to do what the things that make life worth living. And if we look at even health care costs, the majority of health care is spent in those last years of a person's life when they're really sick. So the issue... I mean, you can spend a ton of money at the last few years of your life. And just point out, if you spend it earlier and spend your time differently earlier, it makes, you know, you want to make that correction as early in your life as you can.

9:46You do. You absolutely do.

9:51And you know, instead of having this long slow decline over the end of your life, you wanna live fully and healthily, right to the end and then kinda drop off, you know, square on the monitor. Yeah, and I wanna extend that end. And I wanna extend that end. And I wanna extend that end. And I wanna extend that end. And I'd like to say life is short until you extend it. You know, one interesting stat that, you know, I think most people, and we'll talk about this when we get to mindset, most people have an age in their minds by which they expect to die. And you've gotten it from their mom or their dad's, their grandparents or society as a whole.

10:28And we have to remember that, you know, if you had had that image in your mind a hundred years ago, it might have been you'd expect to get to 50 versus 80. That line keeps on moving and your mindset has a lot to do, but your genetics have some to do, but not as much as people would think, right? So how much of your lifespan, your health span, is a function of lifestyle versus genetics? Yeah, the vast majority is a function of our environment and our lifestyle. Under 10%, probably some estimates around 7 % of our actual longevity is due to genetics. The rest is really due to what we do. And this really brings in the whole concept of epigenetics, right?

11:12my epine just meaning on top of genetics. So we're all familiar with our genetic sequence, you know, the color of our eyes that we inherit from our parents, the predisposition even certain diseases we understand are genetic, like cystic fibrosis. But the vast majority of chronic diseases that we're really familiar with that really lead to that long decline as we get older. Remember aging is the biggest risk factor for all chronic disease. So, cardiovascular disease, cognitive disease, diabetes, metabolic disease, those, yes, there are certain genetic predispositions, but you do not by any means have to get it.

11:51So your genetics, your DNA is not your destiny. It's what you do with that genetics and what environment you put it in. So the food you eat, the thoughts you think, how you move, actually affects how that DNA is expressed. And that's the epigenetics and we can dive into that a lot more if you like. But understand that the key is your health and who you are is really a function of your environment and your genetics interacting. For sure. And I think that's a lot of hope for people because they say, oh my god, my grandparents, my parents died at this age. And I'm like, yes, they did. It doesn't mean you have to.

12:34You can catch and change a disease early. And I think you have to come to it with that mindset, a belief that I'm not going to succumb. I'm going to overcome that situation. And going back to our subject of hand, which is diet, I think diet is one of the places you can make one of the biggest, easiest changes. I always say it's easy. Changing one's diet is not easy, but it's not expensive, and it is doable. And like you said, there's no absolutes. There are a couple of absolutes as far as I'm concerned. Let's dive into those. I would say the first absolute, and I've been on TikTok and Twitter, and I've gotten more of a reputation as a no sugar guy than I want, because I don't wanna be the guy who's just, that's the only thing I'm speaking about, but sugar's a poison.

13:24Let's talk about sugar one second, Helen. Yeah, so sugar is a poison. Now, we need sugar. Let's put that first and foremost. If we don't have sugar, our cell, we can't say alive, stay alive. If our sugar drops to zero in our bloodstream, we will die. So we need sugar. And this is again, it's about balance, but too much sugar becomes very problematic. And when we have sugar floating around in our bloodstream, so that happens when we eat things that get absorbed very quickly, So simple carbohydrates, sweet, bread. What's that mean? Rice, bread. Yeah, so anything like basic sugar, and then things like rice and white bread, things that don't have fiber in them.

14:06When we eat those, those get absorbed very quickly by our body, and it goes directly into sugar in our bloodstream. Now when that happens, that's really dangerous because when we have sugar, it starts to bind to all the different proteins. Now, some of you may understand one of the proteins it binds to is hemoglobin. That's why we can kind of get a measurement of how much sugar the average sugar in your bloodstream by measuring your hemoglobin A1c. That's just a measurement of how much sugar has attached to your hemoglobin molecules or your red blood cells. But sugar also attaches to a lot of other proteins.

14:41Now when that happens, and that's what we call a glycation reaction. So when sugar binds to proteins, it's a glycation. It happens without enzymes. It's just, it's called again, an amodory reaction, and it will happen on its own when sugar is in contact with the proteins. And then what happens is our immune system goes, oh, that looks foreign, right? Our immune system's used to seeing our own proteins, but it's not used to seeing the proteins with sugar molecules attached to it. And so it will actually mount an immune response to it. So we call these proteins that have all the sugars attached them, we call those ages.

15:19And I think that's a really appropriate name, advanced glycation end products, right? And it does. It ages us. And that those ages attach, we actually have receptors for them specifically to get rid of them in our body because they're so dangerous. And those are called receptors of advanced glycation end products or rages. And really are, you know, I think they're really well -named and it does. It causes a full -body wide inflammatory reaction and we can get into what inflammation is as well. But inflammation, that's the pain in your joints, the redness in your skin. And over, we do know that inflammation that doesn't shut off can cause a lot of damage.

16:03It's one of the underlying factors of a lot of chronic diseases. Let's take us a step further because Because again, you need glucose in your bloodstream. Your brain works on glucose and ketones, but it's when the levels get too high. You can wear a simple glucose monitor, which I do, a CGM, a continuous glucose monitor, to look at the glucose levels in your bloodstream. If you have pure sugar or white bread, you'll see this spike. and then insulin gets pumped into your body and it drops down. We'll talk about that in a minute. But what's interesting is that the impact of this glycosolation, this attachment to the glucose, when I think about this, and if you can expand on this, it's a cardiovascular inflammatory, a neuroinflammatory, it feeds cancers.

17:02I mean, there's nothing good about it. Yeah, the the the rage is was just one thing it causes inflammation in your blood vessels absolutely in your brain. You know, there is nothing good about it and one of the hallmarks of cancer to your point Peter is the fact that the cells the cancer cells now all the cells in our body other than our brain cells typically they burn fat. So at rest and when our mitochondria the little power plants of our cell that take the food that we eat and turn it into energy to fuel our muscles to fuel our brain, everything that we need to do, all the reactions in our body, they love to take fat and make energy from it.

17:46Now, cancer cells can only, one of the hallmarks of cancer is that they burn sugar. They can't burn fat. So the mitochondria are so damaged in cancer cells that they cannot burn fat and they only burn sugar. So the whole idea that sugar feeds cancer is absolutely true. And anyone dealing with cancer, the first thing you do is wanna limit the sugar. I mean, we know this because PET scans are basically labeled sugar, right? And that's how we search for... So PET scan is a positron emission tomography, it's a way of... Yeah, it's a kind of scan. Yeah, to look for cancer in the body and it's radial labeled sugar molecules because that sugar will go directly to where the cancer is.

18:31So, you know, I just want to make our first point here, which is the body was never designed to consume this much sugar, right? This use of sugar cane and sugar in our diet is something recent over the last few hundred years. It didn't evolve with us over hundreds of thousands of years. And it's not easy. In fact, sugar is addicting. You know, I have two 12 -year -olds, and I look at the cereals they're eating and it's like all sugar. I mean I taste it and I go, like this is disgusting, it's so sweet, it brings back memories. But you know it's not easy to break a sugar addiction. Yeah it's difficult I think Peter to your point with evolution.

19:14We've actually evolved to have a sweet tooth. So if we think of human evolution, you know we would have periods of feast kind of in the fall during harvest when we had an abundance of food. And then we would have kind of periods of famine, especially over the winter. Now during that fall is when things, sweet things were available, you know, ripe and fruit, this sweet, right? Honey that's available, from that we would go and get. So we have this innate need and I'd say we search out sweet things and sugar. I think that's in all humans. And at the time, it was very beneficial. So what would happen when we ate that sugar, it would induce insulin resistance.

20:00Okay, so remember, when we eat sugar, it comes into our bloodstream, and we then our body senses it. It says sugar's too high, and it will produce insulin. Our pancreas, the beta cells, and our pancreas make the insulin. And the insulin is like the little door knocker on the cell, and it says binds to the receptor on the cell, basically knocks on the door and it says, open up, let the sugar inside. And so the sugar can now go from the bloodstream inside the cell where it's safe. Okay, so that's a good thing. Now over time when we have a lot of sugar around and also fat in there as well, but think of a lot of sugar, what happens is the cell kind of gets tired of opening up that door.

20:44And the little door knocker, our body has to actually produce more and more insulin for the sugar to get inside for the cell to open up the door, almost like the little boy who cried wolf too many times. And so that's what we call insulin resistance, where our cells become, start becoming resistant to the action of insulin. And therefore the sugar ends up staying around in our bloodstream much longer. And that's the first sign of, of course, diabetes when it gets to a certain point. But if we think back to the evolution, during the fall, we would induce by eating a lot of sweets, this sort of state of insulin resistance, which what did that do?

21:28That allowed us to store fat, right? When we're insulin resistant, we store a lot of fat. That sugar gets converted very quickly to fat. And those fat stores would then allow us to survive through the winter when there wasn't a lot of food there. So, you know, the people genetically that can do this, the people that are much more prone to insulin resistance, those are the people that survived, right? And we're all usually descendants of that. So, they're really, if you think about the fit genes, certain traits, depending on your environment, are very beneficial. You take those and you put those in a different environment and they become very detrimental.

22:03So, humans were never meant to be exposed to vast amounts of calories and food and sugar at all times. were meant to go through those periods of feasting and famine. Yeah, so again, bottom line is high glycemic index foods, sugar, candy, all of these things, not healthy for you. My dad used to say an ancient Greek pine methenidestone, which means everything in moderation. And that's fine, but we are addicted to it. The one thing that I do every year with dear friend, Guillermo Navarrete is part of abundance 360 and abundance platinum. We do a 22 day no sugar fast and everybody together in a WhatsApp group.

22:48So it's much easier to do this as a group than on your own is you give up sugar and we go to really a ketogenic diet for 22 days. And at the end of that, you feel like you have control back, right? You have control back over that sweet tooth and you can say no a lot easier. And so I did that two and a half years ago and I've had really, I'm very, very careful about when I eat any sugar. If I'm going to eat something, it's going to be very mindful and it's going to be a very limited amount. So you'll notice when you actually get rid of that sweet tooth, Peter, that things just taste ultra sweet.

23:30You know, when I first cut out sugar in my diet, it takes about three months to completely overcome that craving and that addiction to sugar. And just so you know, sugar is as addictive as cocaine. Well, I haven't tried cocaine, so I wouldn't actually know, but I have tried sugar. But so it takes about three months and then things like the corn flakes that, you know, I used to sprinkle sugar on top of corn flakes. That's all sweet already. Exactly. All right, let's move beyond sugar. So please consider trying a continuous glucose monitor. So you can see which foods actually spike your glucose?

24:06There's a free Libre 3 now. There's a levels. You know, that's the Dexcom, Libre 3 star Libre. They're really very easy. You just stick them on the back of your arm. you monitor the readout with your iPhone, you just download the app, very easy, and very, very informative. And I think when you start using a continuous glucose monitor, I can't recommend it enough, because not only are you going to find which foods actually spike your blood sugar, I think that's important. And you will notice that that's not the same food for everybody. Some foods, it might not spike, one person's blood sugar and another food it will spike a different person's blood sugar very high.

24:50And so that's number one. And then the other thing you're going to get insights in is all the other things that you do, and we're gonna jump into this more, I know later, but how sleep and how stress and how all of those other things have an effect on your blood sugar. So if you don't sleep very well the night before, the same food can spike your blood sugar more. You'll also notice how at different times of day, you're going to be more or less insulin sensitive. So in the morning, typically, we have these, basically, the circadian rhythms and we have clock genes that control those circadian rhythms.

25:27In the morning, you're much more insulin sensitive, meaning the same food will not spike your blood sugar as much as eating that same food in the evening when we're much more insulin resistant. So from a diet perspective, you know, what you eat is critical when you eat is also critical. So the whole, you know, the old adage of breakfast like a king and lunch like a prince and dinner like a popper is actually very true when you take your circadian rhythm into account. And then, you know, how you eat, which we're going to get into in a bit. I'm just going to. In the next three, four years, we're going to all have an AI system that is advising you all the time 24, seven.

26:07But until then, I've got Helen. Okay, so everybody, I want to take a short break from our episode to talk about a company that's very important to me and could actually save your life or the life of someone that you love. Companies called Fountain Life and it's company I starred years ago with Tony Robbins and a group of very talented physicians. You know, most of us don't actually know what's going on inside our body. We're all optimists. Until that day when you have a pain in your side, you go to the physician and they burn to your room and they say, listen, I'm sorry to tell you this, but you have this stage three or four going on.

Read the full transcript

26:43And you know, it didn't start that morning. It probably was a problem that's been going on for some time. But because we never look, we don't find out. So what we built at Fountain Life was the world's most advanced diagnostic centers. We have four across the US today and we're building 20 around the world. These centers give you a full body MRI, a brain, a brain vasculature, an AI -nabled coronary CT looking for soft plaque, dexascan, a grail blood cancer test, a full executive blood workup. It's the most advanced workup you'll ever receive. 150 gigabytes of data that then go to our AI's and our physicians to find any disease at the very beginning.

27:28When it's solvable, you're going to find out eventually. Might as well find out when you can take action. Fountain Life also has an entire side of therapeutics. We look around the world for the most advanced therapeutics that can add 10, 20 healthy years to your life. And we provide them to you at our centers. So if this is of interest to you, please go and check it out. Go to fountainlife .com, backslashpeter. When Tony and I wrote our New York Times bestseller Life Force, we had 30 ,000 people reached out to us for Fountain Life memberships. If you go to FountainLife .com, Backslash Peter, we'll put you to the top of the list.

28:08It really is something that is, for me, one of the most important things I offer my entire family, the CEOs of my companies, my friends. It's a chance to really add decades onto our healthy life spans. Go to FountainLife .com, Backslash Peter. It's one of the most important things I can offer to you is one of my listeners. All right, let's go back to our episode. Let's jump in, so I was saying what are the absolutes? So the absolutes are, listen, sugar's a poison, minimize your sugar, measure what's going on, try yourself going through a 22 day sugar fast, do it with a group of people. That's one piece of advice.

28:46The other sort of, I think, absolute piece of advice is the idea of a whole plant diet that I think everybody can benefit from a whole plant diet. So what is a whole plant diet? Yeah, I mean a whole plant diet is really just what it says is is eat plants You know they eat everything and it's close to its natural state as possible, right for the You want to not too much and again mostly plants is really the they have you want to think about diet but Whole plant food diet is plant forward doesn't mean that you have to be vegan doesn't mean you have to be vegetarian It just means that you should eat really focus on getting plants first and making sure that you Get all of the phytonutrients all of the so why why plants Helen you know I Been a vegan I've I've gone a whole keto diet I've done everything I'm back to sort of Mediterranean diet But when I see literally I see plants on my plate I attack them I'm like, okay, the Brussels sprouts, the asparagus, the spinach.

29:59It's like, I've learned to love my plants, but why is that important? Why is that important? So plants have so many important things. So one of the things that plants have in the only place we can get it is fiber. Now fiber is not only does it fill you up, not only does it control how fast sugar is absorbed into your bloodstream, so it controls your blood sugar, but fiber feeds are microbiome. And our microbiome is, you know, there's all of the trillions of microorganisms that live, it lives everywhere in our body and our skin and our, you know, everywhere. But the vast majority of them live in our GI tract or in our gut.

30:40And those microbes turns out to do so many important things for us. You know, the list could go on. I think every day there's hundreds of papers published on how important the microbiome is for our overall health. And what plants do is that fiber feeds the beneficial microbes. That's absolutely critical. We do not get nearly enough fiber in our diet. You know, if we look at a lot of times, this is only my own kind of hypothesis, but I think we talk a lot about the paleo diet being all meat and the animal that our caveman ancestors would kill. But if you think if you look at what our ancestors ate in terms of fiber, it would be in the hundred gram per day range You know even if you look at traditional populations now.

31:28It's around that Typically the USDA recommends 35 grams a day for people most of us get around five or ten wow We don't get nearly enough Well, you know by the way one thing that we said about microbiome, we'll talk about that more. I mean, every day the research is showing how it's connected to every aspect of your health, your Alzheimer's, brain clarity, cancers and so forth. And then one of the things, I just, you know, you and I talked about this for me a little a little bit ago, a few months ago, which was I had to take some antibiotics for some after my some dental work and I tried to avoid it but I took it in the final result because of a sinus infection but oh my god I hate antibiotics.

32:21It's like they've saved our lives, they've added decades on to your year but keeping your microbiome in good state of health is so important. We'll get to that. I just want to put that note in for folks to think about do not take antibiotics if you have a viral infection, there's so many reasons not to do it. So please, please, please, think about antibiotics. Not only do the antibiotics, and yeah, with the caveat, if you need them, definitely take them. But if there's any doubt, you know, like you said, a viral infection is antibiotics don't kill viruses. They kill bacteria, not only do they kill the bad bacteria, they also kill all of the good bacteria and you're got that way, those beneficial microbes we talked about.

33:01And I will talk later about your mitochondria are in fact bacteria that were incorporated into cells and antibiotics can actually damage your mitochondria. I don't want to dive into the rabbit hole right now. I want to get back to food. So whole plant diets. So one of the things that I recently learned and I found it really an important tidbit, which is the order in which you eat your food can have a massive benefit. So let me lay it out. When you're looking at your plate, eat your veggies first, eat that fiber first, then eat your protein. And then if you still have hunger, you can eat your rice or your bread or your carbs.

33:47So why is that? Yeah, absolutely. So the order that you eat, it will fill your stomach up, and it will slow the absorption of the sugar from those rice and carbs. if you have the fiber in the protein in your digestive system first, you have much lower glycemic response to those foods. So that's a big reason. Another reason is you get filled up with the good stuff, and then less room for you to eat the stuff that's not so good, sort of that, you know, the nutrient poor food. You want to eat the nutrient dense food first. And, you know, the other thing that's in the plants, we talked about fiber, but all of the phyto nutrients.

34:25So phyto just means from plants and nutrients being, you know, all of the such important components that why do we eat? We eat to get building blocks for our body, the protein, and to get energy, and also to give cofactors for all of the biochemical reactions that we need to stay alive. All of those enzymes that carry out those biochemical reactions, those are required cofactors. And that's what vitamins and minerals are. They're cofactors for these enzymes. We can't carry out any of these reactions without those. So that's really important as well, that, and that comes from the plants. It's, I think that's really critical.

35:09And the other thing plants give us is antioxidants. We will get into the whole oxidative stress and free radicals. We can go down that rabbit hole if you like, but free radicals damage in the process of making energy, you know, taking an oxygen in the food we eat, those mitochondria, which you're going to hear over and over again because we're talking about longevity. So they're so important. They have, they have smoke essentially. Think of them as a power plant that produces a bite. They're burning something. They're burning something. And that smoke is reactive oxygen species or what we call free radicals.

35:47And those free radicals cause oxidative damage. So, you know, think of when a metal piece of metal rusts, that's free radical damage or oxidative damage of the metal rusting. So think of that rusting inside our body. It will damage a lot of our proteins and cell, or cell membranes get damaged quite significantly with those free radicals. So in order to deal with that, if we didn't have antioxidants, again, we would all die. We make antioxidants, but we also need to get them from our diet. A couple of key points here as takeaways. Again, please think about this tonight when you're eating dinner or lunch.

36:26Attack your veggies first. Get that fiber in, you know, I like to pour extra virgin olive oil on all my veggies and really consume olive oil in that capacity. So that's the first thing. And then your protein, we can talk about protein from legumes, protein from beans, protein, from fish, chicken. I don't take and read meat. but then the final thing, and I typically skip it because I feel myself on the veggies and the protein can be your carbohydrates. One of the challenges is you go to a beautiful French or Italian restaurant and what's the very first thing they do, they feed you a giant bowl of bread and a glass of wine.

37:04And it's like, so pro tip here, when they bring it to the table, say can you please bring this back with the main course? Because if it's sitting in front of you, you're going to eat it. Or if you need to, make sure that you soak your bread in the extra virgin olive oil to blunt the glycemic response of the bread, but better yet to eat it on the back end of your meal. Exactly. There's another thing you taught me, which is eat the rainbow, and that doesn't mean fruit loops or skittles. So what does eat the rainbow mean? People would try to make it be fruit loops and skittles. But yeah, eating the rainbow just means eating all of the colors of the rainbow.

37:47Because the phytonutrients, the densest nutrition in these plants, are come from the colors. So think of the green and kale and beans and peas, think of the red and tomatoes and strawberries, think of the oranges and carrots and the blue and blueberries and blackberries. That's like, so you want to get what I tell people is try to get one, at least one food of every color every day. That's going to give it because the key, one of the keys of diet is variety. You know, it's great to, and you know how much I love broccoli, Peter. I love broccoli too. But the key is you can eat a big, laid -of broccoli, which is great, but you want to get variety, want to get lots of different types.

38:33So really go for those colors. And when my kids were little, I used to have them check off the colors of the rainbow, make sure they got one of So that's another thing that I attack for Ociously. It's like, you know, we were at our longevity platinum dinner and my team's amazing. They feed us great longevity diets. And I remember in front of the group was these plates of like, you know, every color out there. And I was like, I was just grabbing, grabbing at them. And so, you know, the order which you eat your food, the color of the food, putting off the high glycemic index. Let's talk about one second, nuts, beans, legumes, and then how many calories to consume per day?

39:14Because that is all over the place. So how much protein do you consume? Where do you get your protein from and how many calories? That's an important part of our diet conversation. Yeah, yeah. I think, honestly, calories, I think it is important you don't want to over -consume calories. But to your point, if you eat the right foods first, I think that's a good thing. I think it's really hard to get too many calories when you eat plants. That becomes very difficult. You'll be full before you can have too many calories. Right? And so really go with that first. And then the calories tend to really take care of themselves if you do that.

39:54I used to calorie count. I used to, I don't think, I think, from an ease perspective, just focus on the good foods. And then don't stuff yourself. Stop when you're about 80 % full. Before you go for those seconds, you want to wait about 15 minutes. It takes about 15 minutes for the food to register from your stomach to your brain that you've had something to eat. I can... That's so important, right? You ever have that feeling like, oh my God, I ate too much. Like, it sneaks up on you because there is that delay. And... That's right. Chewing your food and waiting and having a conversation. and then there's vitamin O.

40:35Talk about vitamin O here. People are going to, hold it, what's a vitamin O? I don't remember that from medical school. Yeah, that's, I love it. The vitamin O and that came from Mark David who's just a fantastic, wrote the slow down diet. It's oxygen. Make sure you breathe. So how, and we talked about, you know, taking a deep breath right now. When you eat, but how you eat, right? So everyone, let's do this together. or take a deep breath. And then let it out, out breath longer than your in -breath. And suddenly, I think you can feel how your nervous system switches. It switches from that sympathetic nervous system, or the fight or flight nervous system.

41:17And it switches to your parasympathetic nervous system, which is your rest and digest nervous system. So all of our bodily functions, whether it's urinating or salivating, you know how you're stressed, your mouth dries up. You're clenching them. Yeah, all of those things happen only when we're in a parasympathetic state. And the key is that one or the other can be active at one time. They both cannot be active at the same time. So you're either sympathetic or you're parasympathetic. And so when you eat in that parasympathetic state, you actually make the best use of your food. you're going to digest your food, you're going to absorb the nutrients, you're going to utilize them properly.

42:00If you eat in a stressed state, you tend to just take it all and store it away as fat for a later date. You don't get it. I remember just like, you're food. Shouveling the food in my mouth just to get it done and then get back to my work. And the worst thing, and you said this the other day, and I grew with you, is sitting there watching Crisis News Network, watching CNN and having dinner as bombs are flying and people. It's like that's the worst state to have had, you know, to eat. Yeah. Over the years, I've experimented with many intermittent fasting programs. The truth is, I've given up on intermittent fasting as I've seen no real benefit when it comes to longevity.

42:39But this changed when I discovered something called Prolon's 5 -Day Fasting Nutrition Program. It harnesses the process of autophagy. This is a cellular recycling process that revitalizes your body at a molecular level. And just one cycle of the five day Prolon fasting nutrition program can support healthy aging, fat focused weight loss, improved energy levels and more. It's a painless process and I've been doing it twice a year for the last year. You can get a 15 % off on your order when you go to my special URL. Go to prolonlife .com, P -R -O -L -O -N -L -I -F -E .com, backslash moonshot. Get started on your longevity journey with ProLon today.

43:23Now back to the episode. It is. If you think about how we tend to eat in our society, right, in our culture, we eat when we're driving, right? We'll go through the drive -through and eat when we go through, and that's obviously stressful. We eat at our desk when we're trying to do work. We eat. We read. We can never think of how many times you actually sit and pay attention to your food and don't do anything else other than maybe good conversation with a friend. How many times in our week think about that that we actually pay attention, taste our food, chew our food, pay attention to it versus just kind of shoveling it in because you have to get some calories in.

44:03You know, my sister made a good point. This is part of from cultures around the world. This is why they say a prayer in the beginning or gratitude, grace, it's slowing you down and it's getting you into a conversation, it's preparing your body to absorb the food. So yeah, really, really important stuff. Protein. So, and intermittent fasting, a lot of conversations here, a lot of depth on diet. So, I'm focused this year on building muscle mass, which comes from lifting weights and creatine and other supplements we'll talk about that later, but it's also getting enough protein in my diet. But then you hear conversations around, no, too much protein is not good for longevity, so help me dissect the situation around protein.

44:56How much should we get? Yeah, and I think a lot of it does, we do need protein, number one. So let me say, we do. Proteen makes up the building blocks, our muscles in our body is really made up of protein. collagen and our skin, our bones. So protein is essential and we also know that our muscle mass is a key determiner of our longevity. So if we get weaker, one of the best predictors of mortality in longevity is just grip strength. So overall strength and muscle mass is very important for longevity. So that's really critical. If you think of the elderly frail people that not only do risk falling and all of those things but just And we'll get to this conversation in depth when we talk about exercise.

45:48Yeah, yeah, so, so how much protein should a person get? Yeah, so you need protein in order to build muscle mass and you know, and I think part of it depends on how active you are. You want to like with exercise, you definitely want to be able to lift weight or some kind of resistance training is really important to build and make use of that protein. You want to make sure you digest your protein appropriately because undigested protein can get down into the lower reaches of your colon and then your bacteria will start to ferment that. That becomes a problem because they produce a lot of harmful substances from that protein fermentation.

46:26So you definitely want the protein that you eat, you want to be able to digest and absorb it appropriately and you want to make use of it by exercising. Having said that, the estimates are somewhere around 0 .8 to 1 gram of protein per pound of body weight every sort of daily. And so that kind of gives you a rough estimate. You know, people obviously with kidney disease and other things, they have to be a little bit more careful with the protein, but that's a general kind of. So I weigh roughly 150 pounds and I take in 150 grams a day. And one of the things that's interesting is you can't just take in 150 grams at a sitting.

47:10No, it's spacing it out through the day. That's exactly right. Yeah. And that stimulates muscle building is when you actually space it out during the day. So that's really important. And you don't want to just fast all day and then eat a 20 pound steak. You know, the idea is to definitely space it out to the day. And so you stimulate that muscle kind of building throughout the day. I think that's really important. And you know, we can get into the whole MTOR AMPK and fasting if we want to. Well, let's touch based on it a little bit because I used to focus on intermittent fasting. and I would typically dinner at six or six done by seven, and then I would fast until the next day at about noon, one o 'clock, have a lunch and dinner, skip breakfast.

48:00And I've changed that. And one of the reasons it looks like the data of intermittent fasting in terms of during the day doesn't impact all -cause mortality, but it does impact my ability to take in enough protein. So I said, I'm going to actually take in a protein shake. I use a kachava, which I enjoy as a plant -based protein shake. I do every morning. So what are your thoughts on intermittent fasting? Yeah. So, you know, there are some evidence out there for intermittent fasting being good for people with metabolic syndrome, you know, sort of that whole insulin resistance and that abdominal weight.

48:45So if you're really overweight or obese and you need to lose that weight, Intermittent fasting can be helpful. But if we pull back and we look at kind of what are you know what we did in terms of evolution, what our humans kind of did. Remember we talked about the feast in the famine, you know how you feast in the fall and famine through the winter. I think that there is a role for going for periods without eating. One of the challenges if you go for longer periods without eating is you do lose muscle mass. So when people lose weight, there is a portion of that weight that you definitely lose body fat, but you also lose muscle mass.

49:27So that's something you really have to be careful of. It's because you say one of the strategies for fasting, because you know, some people do a four or five day water fast where it's like just water and electrolytes and that's it. And that's really hard. There is a product that I love that I write about in longevity, which is the Prolon fasting mimicking diet, which is a little bit different. It's a five -day diet, but day one is like 1200 calories in day two through five is like 800 calories and it's nutritional. The studies that they've done, if I understand correctly, and you can amplify, is it's actually more beneficial for you than just a water diet?

50:12Yes, absolutely, absolutely. So the fasting mimicking diet, you get a little bit of food, so it's easier to do because you're not completely not eating. So you get some olives and other things. They also give you something to kind of feed your mitochondria energy without the sugar. And that can be helpful. And they've done some really good studies on it. You know that people lost body weight, right? they they lost that kind of fat mass their waist circumference their blood pressure went down their cholesterol markers improved So there are you know there's been some good studies around the fasting mimicking diet that have been very beneficial You know sometimes I I use it you know in patients as well Just to kind of kickstart them often people with autoimmune diseases and that kind of thing that kicks start using the fasting and the making diet is a really great way to kind of really get them started, especially around elimination diets we can get into that later.

51:15But so there is benefit. I think that you know some people there's still some you know not sort of misunderstanding maybe around fasting and women versus men who is it work better for, I think all of that is we're still trying to tease it out. But there's a role for going for periods without eating and a role for eating. And so doing that once in a while can make sense. Hey everyone, I want to take a quick break from this episode to tell you about a health product that I love and that I use every day. In fact, I use it twice a day. It seeds DSO1 Daily Sinbiotic. Hopefully, by now, you understand that your microbiome and your gut health are one of the most important modifiable parts of your health.

52:01Your gut microbiome is connected to everything. Your brain health, your cardiac health, your metabolic health. The question is, what are you doing to optimize your gut? Let me take a moment to tell you about what I'm doing. Every day, I take two capsules of seeds, DSO1 Daily Sinbiotic. It's a two -in -one probiotic and prebiotic formulation that supports digestive health, God help, skin health, heart health, and more. It contains 24 clinically and scientifically proven probiotic strains that are delivered in a panid capsule that actually protects the contents from your stomach acid and ensures that 100 % of it is survivable reaching your colon.

52:41Now, if you wanna try CEDDS01 daily symbiotic for yourself, you can get 25 % off your first month supply by using the code Peter25 at checkout. Just go to seed .com slash moonshots and enter the code Peter 25 at checkout that's seed .com slash moonshots and use a code Peter 25 to get your 25 % off the first month of seeds daily symbiotic. Trust me your gut will thank you. All right, let's go back to the episode. But let me hit a few other key points on diet, what I eat, don't eat, what I drink, don't drink. So I've eliminated all sodas. With full disclosure, when I go see an epic movie, I may have a Coke Zero, you know, one to twice a year, but that's it.

53:31I've gotten rid of sodas. I don't want, first of all, sugary sodas. And then I don't want the plus fork acid that comes from that. What are your thoughts on sodas? I would say don't. Okay. I mean, fair enough. Yeah, I mean, I can't really think of anything good that comes from drinking or soda, whether you say artificial sweet. Coca -Cola is definitely not good for sports in this podcast.

53:58Okay, so soda's don't. Fruit juices. The same thing. Fruit juices are really all sugar. fruit is different because fruit comes with fiber, the other things that slow down the absorption of the sugar, but the fruit juices are pretty much all sugar. And if you wear that CGM and you monitor your blood sugar when you drink say orange juice, you'll probably notice it go really high. Yeah, spikes. All right, here's a controversial one. And too much fructose isn't too good either. All right, alcohol, vitamin ETOH. So let's talk about alcohol. Is it lemonade? Is it partial? You know, there's a lot of people who swear by it.

54:52I have personally basically gotten rid of alcohol, 99%. I will have a half a glass of red wine once every two or three weeks. I'll have a shot at Dequila on a special occasion. But otherwise, I minimize my call intake. How do you think about alcohol? Any benefits for you? Yeah, there is. A lot of people will say, yeah, there's studies show that there's a protection, a cardiovascular disease. If you have a glass of red wine a day and it's the resveratrol. But if you really look at the evidence and the scientific literature, there's really no benefit from alcohol. You know, as sad as that makes me to say, there's nothing really good that comes from alcohol.

55:40It doesn't mean that you can't enjoy it once in a while to your point, Peter. But be aware that alcohol is a poison. You know, it has a lot of damage. It kills our brain cells. It kills our gut cells and causes, you know, this increased leaky gut, so to speak. It takes a big tax on our liver to actually detoxify it. Even though it can make you sleepy, it doesn't actually improve your sleep. It can actually disrupts your deep sleep and your different phases of sleep. There's really nothing good that comes from alcohol other than maybe in a social situation where you can... a social lubricant, yeah.

56:24Yeah, yeah, absolutely. And unfortunately, I mean what I have noted is if you're trying to keep your glycemic index down tequila is probably the thing that spikes that your blood glucose the least. Yeah, sometimes you'll see that alcohol will if you're wearing a CGM, alcohol can drop your blood sugar. That's very common, but that doesn't mean that, you know, it's lowering, it's not a good way to drop it. All right, one last topic here is water intake, which most people I think don't sufficiently do. That's correct. We have to out water. Our body is made up of mostly water, and we need to drink that and replenish it.

57:12We lose water all the time just in evaporation and urination. It's really critical. I would say a vast majority of us are walking around dehydrated. You know so many times that we also confuse thirst with hunger and a lot of times when we're thirsty we're going to interpret that as hunger and we'll eat instead of drinking and so one of the things You should do is really anytime you feel hungry. Number one drink a glass of water do that first if you're still hungry then okay go ahead and have something to eat but absolutely drink the water first because a lot of times it's because you feel it because you're thirsty.

57:54Is there any downside to sparkling water to carbonated water? Yeah so you know I like it you know I've got my pellarino here. There's certain soda water for example is quite salty it will make you feel first year. But if you like the bubbles, there's not really a huge downside of. And alkaline water? Yeah, you know, there's a lot of conversation around that. A lot of controversy around that. I've yet to see some really good data around the alkaline water. body alkalinity fruits and vegetables are going to really help with that more than the water. If we think of our stomach, our stomach is very acidic.

58:47And so you want that hydrochloric acid, you want that acid in your stomach. And so I think the alkaline water is fine. I don't think there's harm. But I think it's more important just to drink water. good clean water, you know, water is filled with toxins, so make sure it's clean. A lot of the water bottles even, you know, getting the plastics is a challenge. It's a challenge getting good clean water. So I'll wrap up on a few of the products I use here. I use athletic greens as a, you know, if I'm drinking water out of a, you know, a couple liter bottle, just to flavor it and to get a little bit of additional nutrients.

59:26I'll use athletic greens. One of my favorite products that introduced this year is Nutra 11, which is a hot protein drink in the morning. I'm addicted to it bluntly, and I get 20, I replaced coffee with it, which I talk about coffee. You know, I get some 20 grams of protein, and it's flavor with monk fruit as zero sugar, zero carbs, and again, I'm addicted to it. Caffeine, I used to, you know, when I was in medical school, you know, I would five, six, seven, eight cups, you know, keep me going. It was like I pride myself on being able to down down a few cups and go straight to sleep. But now I'm like, holy cow, I can't do that to myself.

1:00:13How do you think about coffee? Yeah. Now coffee in and of itself is filled with antioxidants and a lot of really beneficial a nutrient sin coffee. So coffee is a good thing. Now some people are more sensitive to caffeine than others. Caffeine can increase your heart rate, it can cause adrenaline, cortisol to be released, and some people can handle a lot more than others. Now genetically we can metabolize coffee. It's the SIP -1A2 gene. If you guys are interested, if you're the C in the SIP -1A2, the year you will be a slow metabolizer. I'm a slow metabolizer. I love my caffeine, my coffee. I used to think I was a fast metabolizer, but my genetics came back.

1:01:00I'm a slow metabolizer and you enjoyed, you know, one cup a day, Peter, that's it. And I tried to go to like one or zero a day. Yeah. So the idea is to, you know, limit it if you're a slow metabolizer. or just limit, kind of maybe stop drinking it by noon so that if you do, otherwise you'll have a lot of difficulty falling asleep. All right, so I think we gave diet a pretty good run for its money and hopefully people have taken away some concrete things that can do immediately and it's not expensive to be clear. These are things that you can do immediately that are available to everybody and a lot of it is the way you change what you eat, when you eat, the order you eat it in.

1:01:47And I think it's one of the single most important things that you can do. I want to take a moment to tell you about abundance 360. My year -round leadership mastermind for people who want to go big, create wealth, and uplift humanity. It's singularity university's highest level program. We are a global community of entrepreneurs, CEOs, investors, philanthropists, who have come together based upon a set of shares I'm going to share with you a few of these core beliefs if they resonate with you, consider applying to the membership. We believe in the power of entrepreneurs to solve the world's biggest problems.

1:02:24Second, we believe it is possible to create wealth while at the same time uplifting humanity. Third, we believe that by the end of this decade, 2030, we'll be extending the healthy human lifespan by decades. Next, we believe that the day before something is truly a breakthrough, it's a crazy idea, so embracing crazy ideas is critical to innovation. Next, we believe that exponential technologies create abundance. And finally, we believe that an entrepreneur's mindset is your greatest asset. If hearing these as you thinking that sounds like me and I want to be part of this community, then consider submitting your application to a360 .com.

1:03:09That's a360 .com. We let in about 50 new members every year in advance of our summit between March 17th and 21st. These spots sell out fast, so if you want to get in, consider applying early to increase your chance. A360 .com has everything you need to know. I hope you'll join me. It's an extraordinary group of entrepreneurs and we'd love to have you. Now back to our podcast.

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From the publisher

Aging is one of the greatest challenges to human health

That’s why XPRIZE is launching XPRIZE Healthspan, a global competition that will award  $101 million to revolutionize the way we approach aging XPRIZE Healthspan will create a  paradigm shift where we e can improve human health before biological aging triggers the onset of chronic diseases and disabilities. .

According to XPRIZE, this is the Healthspan Revolution. Learn more about the prize https://www.xprize.org/prizes/healthspan 
____________
In this episode, Peter and Helen discuss the importance of the food you eat and the role of diet in extending your healthy lifespan, allowing you to live longer.

12:19 | Reversing the Signs of Aging

27:56 | The Health Span Revolution

Dr. Helen Messier is the Chief Medical and Science Officer of Fountain Life. She received her BS in genetics and her PhD in molecular immunology from the University of Alberta.

Learn more about Fountain Life here: https://fountainlife.com/ 

Learn more about my executive summit, Abundance360
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I only endorse products and services I personally use. To see what they are,  please support this podcast by checking out our sponsors: 

ProLon is the first Nutri-technology company to apply breakthrough science to optimize human longevity and optimize longevity and support a healthy life. Get started today with 15% off here: https://prolonlife.com/MOONSHOT 

Get started with Fountain Life and become the CEO of your health: https://fountainlife.com/peter/

Use my code PETER25 for 25% off your first month's supply of Seed's DS-01® Daily Synbiotic: seed.com/moonshots 
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Get my new Longevity Practices book for free: https://www.diamandis.com/longevity

My new book with Salim Ismail, Exponential Organizations 2.0: The New Playbook for 10x Growth and Impact, is now available on Amazon: https://bit.ly/3P3j54J
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