3 Broken Breakers Worth Buying

13 Oct 2025 · 29 min · 6 chapters

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In short

“Broken breakers” (stocks/innovators punished by the market) and whether “dark clouds we can see through” create buying opportunities; includes biotech investing impact from federal budget cuts/shutdowns.

Guests

Tim Beyers hosts with Rick Munarriz and Karl Thiel (longtime Rule Breaker teammates/old friends). Carl Thiel discusses biotech policy impacts; Rick and Carl cover stock picks.

Key claims

FDA is mostly user-fee funded, so drug review capacity is partly protected, but during shutdown it can’t accept new NDAs/BLAs; NIH cuts disrupt early research “top of the funnel” for years. Three broken breakers: The Trade Desk is down ~63% and faces AI/CTV competition fears, but connected TV remains a large market and it’s priced <25x forward earnings. Bristol Myers Squibb is hit by major patent cliffs (Eliquis ~2028, Opdivo ~2028) yet offers ~5.6% dividend and new-drug pipeline. Progeny (PGNY) is down ~99% vs market, but self-insured client growth and cash generation plus share buybacks support a rebound thesis.

Notable examples

IONIS Tringolza supplemental approval (no user fee) as a mitigation; GLP-1 early research linked to NIH; Trade Desk connected TV targeting; BMS radiopharma acquisitions; Progeny infertility and added menopause support (20% of existing clients/40% of new considering).

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

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Impact of Federal Layoffs on Biotech

0:46 to 5:42

Discussion on the effects of federal layoffs and budget cuts on the biotech industry.

“of minutes to talk about the federal layoffs and any potential consequences you see for the biotech industry.”

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5:43 to 6:18

Promotion for the Schwab Market Update podcast, highlighting its benefits.

“Up next, three broken breakers we still believe in.”

Investing Principles and the Trade Desk

6:19 to 10:00

Analysis of the Trade Desk as a broken breaker and its investment potential.

“That's schwab.com slash market update podcast.”

Bristol Myers Squibb as a Broken Breaker

10:01 to 14:00

Evaluating Bristol Myers Squibb's challenges and future outlook as an investment.

“I mean, look, I think connected TV has changed everything and logged in experiences for all entertainment is a big boon for companies like the trade desk.”

Progeny: Analyzing a Broken Breaker

14:00 to 20:28

Discussion on the potential of Progeny and its market position amidst healthcare uncertainties.

“And they've made some interesting I mean, they have some fast growing newer drugs that are relatively new introductions.”

Yes And Game: Stock Insights

20:58 to 27:56

Engaging discussion on several stocks using the Yes And game format for insights and concerns.

“All right, it's time for Yes And, which is our improv-style game that Rick brought to us a while back.”
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Transcript

Automatic transcript. May contain errors.

0:05When are broken breakers worth buying? We break it down. You're listening to Motley Fool Money.

0:20Welcome, fools. I'm your host, Tim Beyers. And with me are longtime rule breakers, teammates, and old friends, Rick Munarriz and Karl Thiel. It's a Gen X Power Half Hour. Today, we're talking about our favorite broken breakers, innovators that have yet to convince the market of their long-term potential. Carl, Rick, we've got a lot to talk about. But first, Carl, since we've got you here, I'd love to take just a couple of minutes to talk about the federal layoffs and any potential consequences you see for the biotech industry. And for those who haven't been following along, this relates to federal cuts having to do with CDC and related health and human services agencies.

1:04Carl, what do you see in here and what should we pay attention to as biotech investors? You know, we're seeing things that have been affected both by budget cuts and then also by the government shutdown. I don't want to underplay any of this because every agency that gets cut can have a big impact. But I would say the most important ones near-term for investors is FDA. The good news there is that FDA is largely funded by user fees, so drug companies literally pay for their own reviews, which does mitigate the impact somewhat. The agency has said something like 86 % of employees are still active, and that keeps them active even through the government shutdown.

1:48The bad news in that regard is that there are certain things that they cannot do during the government shutdown. One of them is accept new NDAs or BLAs. You cannot accept any new drug application that requires a user fee payment because literally there's nobody to operate the till. If you're trying to submit a new drug, you can't do it during the shutdown. This is one of those things that if the shutdown is a few weeks, hopefully that doesn't impact things too much. Obviously, the longer that drags out, the more serious that gets. Companies that already have pending applications for the most part should be okay.

2:32Companies that are looking at making new submissions a little further out, hopefully we'll be back in business by then, but there is a little awkward period right now. I will say there's some mitigation to that as well. If you're a company that's trying to submit a new drug application that is for something already approved. To pick a random example, IONUS has said this year that they're going to submit an approval for a drug called Tringolza, which is for high triglycerides. It's already approved for a rare disease. And because this is therefore a supplemental application, it doesn't require a user fee and they should be able to submit that on the normal schedule.

3:10Right. So that's the sort of good news and bad news on that. And then, you know, I think the other biggest impact for the industry has been all the NIH budget cuts and grant issues. And again, that's sort of a good news, bad news story. I mean, the impact on it is really at the top of the funnel for research, which is that a tremendous number of ideas come from NIH research. And just to pick an example, you know, you can come up with these stupid sounding studies that NIH is doing. It's like, why are we paying taxpayer money so somebody can study the diet habits of the Gila monster in the Southwest or something?

3:51But that's, in fact, where GLP-1 drugs come from, is that kind of early, early research. And so you're hurting the top of the funnel when you do that. The good news, such as it is, is that the current budget, which is not being passed because of the shutdown, but the current budget calls for basically both the House and Senate versions call for restoration of most of NIH funding. This is one area in which House and Senate Republicans, for the most part, kind of push back against the White House and they want to restore most of that funding. So hopefully, the impact will ultimately be less than it could have been.

4:32But it's still extremely disruptive and it's going to work through the funnel for years. Okay. So just a quick follow-up on this and then we'll move on. I think what I'm hearing from you is that there are some short-term disruptions here, but we like early-stage biotechs in rule breakers. You're the one that brings us most of these. This does not sound like something that over the long term should dissuade us from getting interested in emergent science in biotech. There's going to be maybe some short-term disruptions. There will be possibly some approval delays, but over the long term, we still should like emergent science biotechs because those are still necessary and will come to market.

5:26Yeah, I think that's right. And I do think there is an expectation that some of the sort of most radical moves made by the administration will be mitigated or reversed at some point. Got it. Okay. We'll keep our eyes on this. Fools, let us know what you think and what emerging biotechs you're investing in. Up next, three broken breakers we still believe in. Get a concise daily market preview from Charles Schwab, including stock updates, U.S. and global economic news, monetary policy decisions, and key results and statistics that may impact your trading. Schwab Market Update is an original podcast from Charles Schwab.

6:07Join host Keith Lansford for this information-packed daily market preview delivered in 10 minutes or less. Listen today at schwab.com slash market update podcast or wherever you get your podcasts. That's schwab.com slash market update podcast. All right, welcome back to Motley Fool Money. We like dark clouds we can see through. And if you don't know what that principle means, I'd like to introduce you to David Gardner's new book on Rule Breaker Investing. Dark clouds we can see through means, and it's a long-held principle of David's in Rule Breakers. We aren't trying to buy the low, but we love it when a company that we really believe in that has significant Rule Breaker traits gets punished for reasons that maybe are temporary or maybe are unfair.

7:00And so we like these companies as rule breakers that may have kind of taken a backward step for reasons that are partially their own fault, but maybe not completely. There are dark clouds. We can see through them, and we're willing to stick it out and wait till the sunny skies return. And we're going to talk about three of them. And, Rick, I'm going to start with you. We're going to start with the trade desk because, boy, has it been – I mean, is it just raining on their boardroom? What's going on here? Yeah, yeah. It's raining in their boardroom, and apparently it's like an open roof. It's a convertible boardroom because they're getting soaked.

7:39But yeah. So the Trade Desk, it's a 15-bagger since becoming a rule breaker recommendation eight and a half years ago when Carl Thiel and I coincidentally just approached David Gardner at the same month and said, hey, we like this stock. Carl and I rarely have the same stock on our minds, but we did that time. But it used to be a shinier star on our scorecard. The leader in programmatic advertising has fallen 63 % since peaking 10 months ago. Obviously, that's more than rain. That's a deluge. The first hit came a few weeks after its all-time high, when after 33 quarters of breezing through guidance, it proved mortal.

8:12Two quarters later, it's its most recent quarter, it missed on the bottom line, and revenue failed to top 20 % for the first time as a public company outside of the second quarter of 2020, when advertisers sort of took a mulligan. They took a quarter off early in the pandemic that time. But there are fears there. There are fears that it's AI deployment having gone exactly as planned. There's fears of a competitive market, specifically connected TV, which is always seen as this big growth for them. Amazon is emerging as a force. The open Internet. But here's the thing. The open Internet. It's a$935 billion market opportunity for digital advertising.

8:47It's never going to be a one-eats-all market. Connected TV is still powerful. Advertisers are willing to pay twice as much to reach a connected TV viewer, where campaigns can be personalized and targeted than traditional advertising. The trade desk was once priced for perfection. Now it's only priced for imperfection, but it's also priced for infection. A lot of people just are doubting the trade desk. That's a good place to go and be a contrarian, and I see that now. You can pick up the trade desk for less than 25 times forward earnings. I'll say this again. You can pick up the trade desk for less than 25 times forward earnings, which may be a high multiple in most cases, but if you know the trade desk, you know that it never trades as cheap.

9:24And yes, revenue growth is slowing and analysts see it slowing. Its guidance calls it to continue to go in the high teens in the current quarter. Analysts continue to see it in the high teens next year. There's still a lot of things happening here with the trade desk, but I think it's a steady growing company, still gaining market share because there's no way the advertising market is growing at a double-digit pace. And I think right now that it's priced actually reasonably, despite warts and all, I believe it is a broken breaker that is mending itself. And to be honest, I don't think it was ever truly broken.

9:55I think it was just too much optimism. So cracks in the price, but not cracks in the business. Fair enough. I mean, look, I think connected TV has changed everything and logged in experiences for all entertainment is a big boon for companies like the trade desk. But let's go back. Let's go back to health care. And, you know, I mean, Carl, Bristol Myers Squibb. Bristol Myers Squibb is one of these companies, by the way, that does not seem like it's been around. I think people would be shocked about how long it has been around. Tell me what you think here. Why is this one a broken breaker? It's pretty clearly broken.

10:44I mean, you could argue that it's not a breaker. And I would say that that's fair enough. I mean, this is a drug company that's well over 100 years old. It came to us on our scorecard through Celgene. That's right. Bristol acquired Celgene. It swallowed a breaker. Exactly. It swallowed a breaker and has continued to struggle since. And I would say that it is a broken breaker that I've come to believe in again. And that is basically a valuation argument. So, this is not usually where we're coming from for rule breakers, but I think it's a reasonably compelling case in which you have a company that's guided for earnings per share in the$6.50 range there, a little bit to either side of that.

11:37Revenue is going to be around$47 billion this year. That gives them a P.E. multiple of less than seven. I think that number alone tells you that there's some trouble at this company. But I think that trouble is pretty well recognized at this point. They have one of the worst patent cliffs in the industry. And a patent cliff is when a drug that you've been selling for a very high margin, lots and lots of money, suddenly goes off patent, generic competition comes in, and your market share tanks, and pricing pressure goes way up. That's going to happen with Eliquis. That's going to happen in the 2028 range with Opdivo.

12:20It's a challenge. This is a company where you're going to see both profits and revenue drop for a period of years. But I think that is more than priced in at this point. And the company is paying a dividend in the 5.6 % yield range. And it's a dividend that I think you can count on. They have a 93-year history of paying a dividend, 93 consecutive years. There's no reason they're going to stop doing that. They're not in danger of dropping out of profitability. In fact, their portfolio of new drugs is growing quite nicely. and being offset by legacy drugs that are seeing decline. So I think it's a pretty surefire way to collect a very nice yield.

13:11And then I think eventually start to see some price appreciation as that very, very pessimistic multiple just kind of even comes back a little bit. Is it possible that that multiple expands once we start to see? Because if I heard you correctly, and I think I did, The idea is that they, I mean, look, they're facing a giant patent cliff, but it's not like they've stopped innovating and they are building a backlog of drugs. And so this is the old dog that's cooking up new drugs. Sorry, I made it sound way too much like Walter White there. I didn't mean to do that. But you know what I mean? Like there's a big backlog here.

13:52And if if that backlog starts to show promise, that multiple could expand quite quickly. Yeah. And I think even just just any sign that they're going to, you know, be able to return to growth will do that. And they've made some interesting I mean, they have some fast growing newer drugs that are relatively new introductions. And they made some interesting acquisitions around radiopharma, for instance, and some some next gen oncology drugs. So, yeah, I mean, you know, I think this is a point in which there are lots of reasons to be negative, but you're sort of at, you know, I don't want to say we're necessarily at peak negativity, but I would say that there's definitely a very dark cloud hanging over the company and any sign that that's lightening up could help with the actual stock price, even while you're just collecting the dividend.

14:39All right. So not just dark clouds, storm clouds. Fair enough. I'm going to take Progeny and Progeny, ticker PGNY. I've talked about this before. I own it. Ever since our full 24 interview with CEO Pete Denevsky, I've been interested in this company. And part of the reason is that it has gotten so destroyed. On the Rule Breaker scorecard, down 41 % as of our taping, down 99 % versus the market. It is broken in terms of the price here since the IPO. But that does not mean that these are unnecessary services. In fact, I think they are growing in importance. And so, they're not getting enough credit because I think the healthcare market is, and Carl, I'll be curious if you have a thought about this, but this is my view of it.

15:35because the healthcare market is so Byzantine, there's so much debate about it, there's so much worry about prices, this kind of business and product, which is essentially aimed at those who self-insure, which is not a lot of companies. I mean, it's a growing number of companies that do self-insure. They kind of manage a bucket of money. They use an insurer on the front end, and then they pay benefits on the back end, and they get discounted versions. And then they kind of build a menu. The Motley Fool is like this. As full-time employees, this is what we have. We are a self-insured company, and we have good benefits.

16:13And the company works within a structure in order to do this and has been very successful at it for a lot of years. And we offer progeny as a benefit. And you know what? I mean, I think we are going to see a lot more of this. Now, revenue was only up 9.5 % in the most recent quarter. But I will say this, gross profit increased 16%. So there's more efficiency here. It's a profitable company generating cash flow. And this is what I like the most, that despite all of this uncertainty around healthcare, the client base, so again, self-insured companies expanded to 542 in the most recent quarter. And that was just about 6.75 million members.

16:58So these are covered individuals under progeny. That's up year over year from 473 clients, which again, self-insured companies, that's a lot. That's fairly big growth. And the number of covered people underneath that was, again, grew to 6.75 million, up from 6.47 million. So there's clearly a whole bunch of companies that are interested in progeny services because they do have some better indicators and results for helping those who are having trouble building a family, starting a family. They're well-known, their principal product is for infertility, and they tend to help those couples who are trying to have a child.

17:44They tend to show clinically better results, and that does show up. They get chosen more often. And so this is another piece of this. They do have other things they're doing. One of them is they've introduced menopause support, and there's strong initial reception for this. 20 % of existing clients and 40 % of new clients are considering taking up progeny on that menopause support. And this is not the only extra service that they're working on. Last point on this, so Inevsky and a lot of his leadership team, back when the stock was a little lower than it is today, it was still in the teens, but they were active buyers on the open market.

18:26They're not selling shares. They've been, if anything, accumulators of shares. And that's another thing I like about this. But I don't know, Carl, I'll ask you to tell me I'm wrong if you think I'm wrong. Is just the generalized confusion and concern about the healthcare market something that is a dark cloud that weighs over a service like Progeny, especially since it's for those companies that are self-insured? Well, I'll put it back to you just a little bit, which is beyond that concern, which, you know, hard to say how people are regarding it. Do you think there's a concern just that, you know, the client base is, as you say, you know, mostly self-insured companies, that there's just a sort of simple, cyclical economic concern around layoffs and sort of economic contraction around some of those companies, you know, that might be something that's holding the company down and also something that you presume we get past.

19:27Yeah, it could be. The other piece of it, though, is that as they introduce more services and the existing clients use Progeny for more things, you would think that offsets. Rick, do you have a thing you want to add here? Oh, yeah. When you mentioned the buybacks. So, yeah, they've retired almost 10 % of their shares over the last year and a half. It was mostly done last year, but it's still in there. But to me, I see the point here again, and I'm just connecting the dots here, which I think is what we do as rule breakers, but couples are settling down later in life than they used to. This means fertility treatment, surrogacy, adoption, all these things that Progeny helps out are going to become more popular.

20:02They're going to want that when it comes to coverage. And that's going to be great for Progeny, I would think. Yeah, I think that's right. So let us know what you think. What's your favorite broken breaker? Give us a comment wherever you consume your podcast, just leave us a comment and let us know. we'd love to hear it. Up next, we play the yes and game again. Stay tuned. You're listening to Motley Fool Money. Trading at Schwab is now powered by Ameritrade, bringing you an expanding library of education with even more ways to sharpen your trading skills. Access new online courses, insightful webcasts, articles, engaging videos, and more, all curated just for traders.

20:44Plus, guided learning paths with content designed to fit your unique interests. No sifting to find exactly what you need so you can spend your time learning to trade brilliantly. Learn more at schwab.com slash trading. All right, it's time for Yes And, which is our improv-style game that Rick brought to us a while back. If you like this game, write me a note, tbuyers at fool.com. Let us know because we'll keep bringing this back. If you want something else, I'm going to keep playing faker breakers, faker breaker, and we're going to keep doing yes and. So as a reminder, the yes and game is pretty simple.

21:23We start with a bullish statement about a stock, followed by another, and then followed by a concern. We go around the horn with three stocks taken from our rule breakers database. And we just make a statement about stock. And then it's yes and, yes and, yes but. We raise a concern, and then we end the scene. We're going to do this for three stocks. When you are ready, Carl, we're going to start with you and your pick, which is Arginix. All right. I'll test my ability to make compound sentences.

22:02Arginix, based in the Netherlands, is a very successful biopharma company. sells a drug called ViveGart, mostly for myasthenia gravis. Sales jumped 97 % to$949 million in the second quarter. That's nearly a$4 billion run rate and still growing. Yes. And as strong as stateside sales have been, it's growing even faster outside of the U.S. market. Yes. And it appears that ViveGart is positioning to capture, do I have this right, Carl, 50 % market share in CIDP. That is an extraordinary number. You are right. Yes, but any market this good attracts a lot of competitors, and there are some very serious ones that could be better than ViveGuard.

22:53Yes, but U.S. accounts for more than 80 % of current product sales of the Netherlands-based company. That's a lot in the recipe of a foreign company relying largely on the U.S. market for sales. Yes, but it does look like in Q1, there was a bit of seasonal insurance reverification delays and increased Medicare Part D utilization, leading to higher discounts, missing investor expectations. The regulators aren't always friendly with this one. And scene. Excellent. Carl, you did it. There's your first. There's your first. Now, we're going to go to the expert here. Rick, Celsius, let's do it. Yeah.

23:37Celsius is a disruptive leader in the growing functional beverage market. Yes. And I see this every day, Rick. Every time I get on a bus or a train to commute into the office, I see at least one Celsius drink, not only on the way, but in the office where I end up going to work. Celsius, no matter what we say about its growth rates, It is everywhere. Yes, and it widened its footprint by acquiring Alani New and managing the Rockstar beverage and deepened its stake with Pepsi. Yes, and that PepsiCo deal, PepsiCo increases stake in Celsius from 8 % to 11%, getting a great distribution partner even deeper in exchange for Celsius taking over that Rockstar brand.

24:26Yes, and the company's international division grew by 37 % to$18.6 million. That's including expansion in Canada, UK, Ireland, Australia, New Zealand, and France. So, a successful global market penetration is happening. Yes, but Celsius risks cannibalizing its brands with this much larger portfolio of beverages. Yes, but after three years of revenue more than doubling, investors saw how fickle the energy drink market can be for Celsius last year. Yes, but U.S. revenue did plunge 33 % year-over-year to$247 million. Good foreign revenue, not as great on domestic shores. And seen. All right, let's talk Salesforce.

25:17Salesforce has closed over 12 ,500 agent force deals since launch, and more than 6 ,000 of those are being paid deals, Salesforce is really ramping up its AI. Yes. And in their Q2 for fiscal 2026, they raised their full year revenue guidance to over$41 billion and are looking at improvements in operating margins and solid cash flow growth. Yes, and Salesforce.com has a strong track record of making shrewd acquisitions that can amplify through its own ecosystem. Yes, but Salesforce is now trading for a premium that is going to be hard to justify as the AI hype starts to die down, even with all that free cash flow.

26:09Yes, but they confirmed 4 ,000 job cuts in 2025 and some hiring pauses showing some struggles underneath the hood. Yes, but after decades, and I mean two, three decades of annual double-digit growth sales consistently, revenue rose at a single-digit clip in fiscal 2025. And scene. All right, fools, that's Yes And. Let us know what you think about the Yes And game. Let us know what you think about our broken breakers and which broken breakers make the most sense for you. Do check out when you want to hear more, if you want to hear more about dark clouds, you can see through and all of the various Rule Breaker trades.

26:52Please check out David Gardner's new book, Rule Breaker Investing. For those who want to learn the long-term benefits of compounding in high growth, high quality companies, it's a great place to start. Thanks to Rick and Carl for joining me today. As always, people of the program may have interest in the stocks they talk about, and The Motley Fool may have formal recommendations for or against, so don't buy or sell stocks based solely on what you hear. All personal finance content follows Motley Fool Mediterranean standards and is not approved by advertisers. Advertisements are sponsored content and provided for information only.

27:32To see our full advertising disclosure, please check out our show notes. Please also tune in tomorrow when Emily will have a bit more Rule Breakery content for you. For Rick Munarez, Carl Thiel, our engineer is Dan Boyd, and our producer is Anand Chakrabilou. I'm Tim Byers. Fools, see you again soon. Go on, everyone.

From the publisher

Long-time Rule Breakers Karl Thiel, Rick Munarriz and Tim Beyers offer up three stocks that face dark clouds they can see through. Who are your favorite Broken Breakers?

Karl Thiel, Rick Munarriz, and Tim Beyers:

- Discuss the implications of mass restructuring at the federal agencies governing biotech and health care innovations.

- Profile 3 stocks broken by bad decisions, bad luck, or bad timing, but which still have plenty of Rule Breaking potential.

- Play another game of Yes, And! with three stocks from the Rule Breakers Database.

Don’t wait! Be sure to get to your local bookstore and pick up a copy of David’s Gardner’s new book — Rule Breaker Investing: How to Pick the Best Stocks of the Future and Build Lasting Wealth. It’s on shelves now; get it before it’s gone!

Companies discussed: ARGX, CELH, CRM, TTD, BMY, PGNY

Host: Tim Beyers

Guests: Karl Thiel, Rick Munarriz

Producer: Anand Chokkavelu

Engineer: Dan Boyd

Disclosure: Advertisements are sponsored content and provided for informational purposes only. The Motley Fool and its affiliates (collectively, “TMF”) do not endorse, recommend, or verify the accuracy or completeness of the statements made within advertisements. TMF is not involved in the offer, sale, or solicitation of any securities advertised herein and makes no representations regarding the suitability, or risks associated with any investment opportunity presented. Investors should conduct their own due diligence and consult with legal, tax, and financial advisors before making any investment decisions. TMF assumes no responsibility for any losses or damages arising from this advertisement.

We’re committed to transparency: All personal opinions in advertisements from Fools are their own. The product advertised in this episode was loaned to TMF and was returned after a test period or the product advertised in this episode was purchased by TMF. Advertiser has paid for the sponsorship of this episode.

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