Ben Lamm CEO of $12B Colossal Biosciences & $3.8B Astromech

20 Aug 2026 · 1 h · 23 chapters

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In short

Ben Lamm, CEO of Colossal Biosciences, discusses de-extinction and biodiversity loss, Colossal’s “digital twin of nature” vision using AI, and how de-extinction tech could support conservation and public-health goals. He also explains Colossal’s vertical integration and funding, plus Astromech’s AI drug-discovery approach.

Guest backgrounds

Ben Lamm is CEO of Colossal Biosciences (reported $12B) and a founder/leader behind Astromech (reported $3.8B). He frames Colossal as a tech/product company with systems engineering across genome engineering, biobanking, and artificial wombs. (Podcast host is not identified in the transcript.)

Key claims

Biodiversity loss may reach 50% in 25 years. Colossal produced “100% healthy” Gen-1 woolly mouse offspring with predicted phenotypes using multiplex editing delivered in 30 days. Lamm argues de-extinction is not a replacement for conservation, but a “backup plan” and net-new tech/money. He predicts AI will enable a real-time digital twin of nature.

Notable examples

Woolly mice (Gen-2 shown), direwolf “installation” (animatronic + projected footage), permafrost tissue/cloning limits (dead cells can’t be cloned), gene-drive biocontrol for invasive species (e.g., screw worm), and Astromech’s elephant/cancer example (p53 differences; elephants ~2–3% vs humans ~24–25%).

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

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The Biodiversity Crisis and Genetic Innovations

0:00 to 1:09

Learn about the urgent biodiversity crisis and innovative genetic projects.

“It's currently forecasted that we're going to lose up to 50 % of all biodiversity in the next 25 years.”

Inside Colossal's Facilities

1:14 to 2:10

A tour of Colossal's lab and the inspirational work being done.

“We thought that most people, when they come here, they want to see, they're like, oh, can we see the Dyerwolves?”

The Direwolf Installation

2:10 to 3:18

Discussion on the animatronic direwolf and its significance.

“So even thinking about tropic downgrading grading and the cascading effect that happens with wolves, like the reintroduction of wolves into Yellowstone and what that looks like and why predators are important.”

Understanding Genetic Editing

3:18 to 4:42

Explains techniques and challenges in genetic editing for species revival.

“So you want to show us around what you have in the lobby area and then you can kind of explain what's behind the closed door.”

Creating a Digital Twin of Nature

4:42 to 7:50

Ben discusses the concept of a digital twin of nature and its implications.

“And then I think we have the coolest street wear that no one can get.”

The Woolly Mouse Project

7:50 to 12:20

An overview of the woolly mouse project and its breakthroughs.

“So I think understanding a digital twin of nature so that we can pick and choose the trade-offs as a society is going to be critical to our long-term success.”

The Future of Civilization Tech

12:20 to 14:01

Explores the concept of civilization tech and its impact on humanity.

“There were people that actually made like legalized woolly mice t-shirts on Etsy, which is weird because they're not illegal.”

The Future of Moonshots and Biotechnology

14:01 to 24:58

Discussion on moonshot technologies and their broader impact on humanity.

“I think it's the evolution of the moonshot category, right?”

Biodiversity and Conservation Challenges

26:25 to 28:00

Exploration of the dark statistics on biodiversity loss and conservation strategies.

“It's like it's like but but like it's dark, but I think it's hopeful, right?”

The Dual Nature of Technology

28:00 to 28:56

Discussing the potential positive and negative uses of technology.

“That doesn't mean facial recognition is bad.”
Show all 23 chapters

Conservation Community Challenges

28:56 to 30:20

Exploring the initial resistance from the conservation community.

“So I was talking with Katie, and she was telling me how she got to here.”

The Importance of De-Extinction Tools

30:20 to 31:32

Considering the necessity of tools for species conservation.

“But in the early, to her point, in the early days, it did take some long conversations with that community because that community is very stuck in its own ways.”

Collaboration and Government Support

31:32 to 34:28

Discussing the need for collaboration with various stakeholders.

“But but ultimately, I would rather have this technology set and not need it or at least use it in these interesting capacities that help individual species and help inspire the next generation.”

Innovative Approaches in Biotechnology

34:28 to 37:06

Understanding the unique approach in biotechnology at Colossal.

“And if you know and if you're just a if you're somewhat fiscally minded, you're going to save the taxpayers money.”

Engagement with Youth and Education

37:06 to 40:14

Highlighting the importance of engaging youth in science and education.

“with more and more innovations that come out of the company.”

Evolving Funding Strategies

41:44 to 42:00

Discussing the evolution of funding strategies and investor relationships.

“Well, so we should talk about your funding history.”

Investor Strategy and Impact Focus

42:00 to 43:49

Learn about the strategic approach to attracting long-term investors focused on impact.

“Like we wanted to have a long term investors, technology focused investors, people that could that can look at like, OK, here, what is this event horizon?”

Building Trust and Managing Expectations

43:50 to 46:20

Discover how trust and expectation management have aided in raising capital successfully.

“So what I hear from that is we're cheap.”

Innovations in Cloning and Science

46:21 to 49:28

Explore advancements in cloning techniques and the integration of AI in science.

“We haven't done this yet, but we're now pushing a new construct that we've designed and a new delivery mechanism that we think we can be doing thousands of edits at once.”

Creating a Unique Brand Identity

49:29 to 52:18

Understand the creative process behind developing a distinctive scientific brand.

“How did you get, I mean, you have a very distinctive style here.”

Ethical Boundaries in Genetic Engineering

52:19 to 56:00

Examine the ethical considerations and boundaries in synthetic biology projects.

“And your labs are like held up by pizza boxes, right?”

The Power of Synthetic Biology

56:00 to 57:25

Explore the transformative potential of synthetic biology and AI intersections.

“And then we just reconnected, like, literally in the last week.”

Conspiracies and Misconceptions

57:25 to 59:00

Delve into the bizarre conspiracies surrounding Colossal and genome engineering.

“So this just shows how like fucked up the world is.”
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Transcript

Automatic transcript. May contain errors.

0:00Ben Lamm:It's currently forecasted that we're going to lose up to 50 % of all biodiversity in the next 25 years. So that's dark. These are some of our woolly mice. Woolly mouse. Russell's woolly mouse. They've begun an experiment. In their plan to revive the woolly mammoth. It's a f***ing good mouse. And the way the world is right now, let us have this. So we had 100 % healthy mice born with exactly the predicted phenotypes with the most multiplex edited delivered at one time ever. And we did it in 30 days. So the last one was 400 million. You've raised 630 million in total? Yeah, 635 total. The last round was supposed to be 200 and it got overspread to 400.

0:40Ben Lamm:We're just getting started. I'm sure we'll raise more capital. One of our companies that we spun out called Astromech, it's using AI to build, it's a very focused models. We do get the request of Metodon quite a bit. We're not working on the there's no secret US Navy anduril mashup. They don't ask you to do your work on the aliens.

1:08Ben Lamb, welcome to Sorcery.

1:10Ben Lamm:Welcome to Colossal. Thank you. This place is insane. Yeah, it's funny. It just waits you go through the tour. It gets crazier. So we have something pretty nuts over here yeah yeah do you want to show us what's going on so believe it or not uh we do not have 330 pound uh massive extinct pleistine wolves here uh and so we built an animatronic of one and that actually is the size of remus uh one of the probably the most famous of our dyerwolves it was on the cover of time and then uh we constantly uh have footage from the last six months that we project here. We thought that most people, when they come here, they want to see, they're like, oh, can we see the Dyerwolves?

1:53Ben Lamm:And we're like, we're in Texas. Like, where do you think we have them? You're in an office building, right? And then, you know, we try to, like so much of what we do is around inspiration and kids, right, because like value creation, impact and inspiration are kind of our big core values that we try to think through all of our decisions. So even thinking about tropic downgrading grading and the cascading effect that happens with wolves, like the reintroduction of wolves into Yellowstone and what that looks like and why predators are important. So we've tried to think about long-term with our museum partners, how do we start to educate the public on the importance of keystone species and specifically predators.

2:33Ben Lamm:So this is our direwolf installation. We can thank Weta from New Zealand. If you're a fan of Peter Jackson, you'll know those guys. And yeah, here's that's actually Romulus, you know, chewing on something disgusting. So, yeah, but this is well, you know, I don't know if every single office you've been to has animatronic direwolves. No, I have not seen any animatronics. So I'm sure there'll be some like crazy conspiracy based on that. But they're like, oh, the direwolves are robots. They're really a robotics company. We get lots of interesting feedback. Yeah, we get lots of feedback. I have confirmed we went into the Avion or Avian lab.

3:13Ben Lamm:Yeah. That birds are real. Yeah, birds are real. Yeah. Birds are real and the stuff we're doing is real. So it's kind of fun. Yeah. Okay. So you want to show us around what you have in the lobby area and then you can kind of explain what's behind the closed door. So this is 55 ,000 square feet. We have another 30 ,000 square feet of our lab space. Everything wraps around the lab, which you're going to get to go deep in, which is exciting. Everything, like all the offices, all the conference rooms, everything, all our AI teams wrap around the lab because science is the heart of what we do here.

3:45Ben Lamm:Also made by Weta, most people think this is what we do. But as you spend time in the lab, you'll see it's way weirder and grosser and more technical. But most people are like, why don't you have a mammoth? Or why don't you have a dinosaur? Why can't you just take frozen core samples and clone them? But those tissues are dead. You cannot clone from dead cells. but we put this here because this is what most people think that we do like when we launched like every cover uh was like something like this of like some mammoth preserved in ice just so you know they look nothing like this uh they're disgusting and the smell is awful even the permafrost like you can't get it out of your pores forever yeah so i spent a bunch of time up in alaska in the permafrost caves in in northern alaska in the arctic circle and it is just it's I mean, it just gets in you and it's disgusting.

4:33Really? Yeah.

4:34Ben Lamm:Yeah. But you could just pretend it looks like that and it smells like this and it's incredible. But it does have its own signature scent. And then I think we have the coolest street wear that no one can get. It's like science street wear. I have no idea. Yeah. It's super awesome, right? You guys have, everybody's wearing it too. You guys have great merch. Yeah. Yeah. So, but we don't like sell it. It's only available to our employees, our favorite guests. But yeah, it's like, you know, we want to provide the greatest apparel. You know, it's not swag. It is apparel. And then everything that you see, like when you go into the lab, we want to have all of these different educational moments that are talking about our core values or explaining specifically to the lab of that specific unique lab.

5:20Ben Lamm:Because we have a core lab that's an open lab. Then we have individual labs off the core lab. So this is like one of our production labs. and whatnot. So sharing our core values, reminding people what they do is great. But the other thing that we've done is like, we've tried to pick technologies like, so on the other side, and you'll see this in the lab, you actually can't see any of this. So this is one way projecting. It's not a projector. It's actually one way. It's actually a nanofilm. So we can see it, but it's not distracting. So like when you're going to lunch, you're going to a meeting or you're going to the bathroom, you consistently are reminded of the things that matter and the things that we take pride in.

5:59Ben Lamm:But when you're working in the lab, it's not distracting. Ben, I have to ask you, what is your hottest take right now? My hottest take right now is that I think AI is going to converge and we are going to build a digital twin of nature. And just like we have prediction models for like everything from like missile defense to tsunamis and earthquakes. We're gonna have that for nature. And we're gonna understand in real time like how nature is affected by every decision that we make. And that's gonna be incredibly enlightening and terrifyingly scary. But I think we're gonna build a digital twin of nature, we as humanity, where we will be able to truly understand the consequences of our decisions.

6:47Ben Lamm:and then we will be able to leverage technologies like what we have to productionize species to combat some of the adverse effects of those decisions so why is that so important you study yeah it's so important to me because i think that ultimately we don't really know how everything works like we as humanity like we're like oh when people get locked in their houses for covid all of a sudden there's like dolphins back in in italy right but it's like why right and so for us thinking through and understanding the ramifications of that, thinking through like how that affects things like water purity and scarcity, food security, all of these things are directly impacted by the ecosystem.

7:28Ben Lamm:And that's also driven by the flora and fauna that are there. And so if we don't understand the ripple effects of either eradicating a species or building XYZ data center, well then, or diverting a river, then we don't understand like what that means to us from even our survivability of a new zoonotic disease that arises or food or water security. So I think understanding a digital twin of nature so that we can pick and choose the trade-offs as a society is going to be critical to our long-term success. And I see a world where all these systems, including AI, actually make it where we're better aligned with nature.

8:08So what are you looking forward to most in the next 12 months?

8:12Ben Lamm:uh the next 12 months i'm looking forward to colossal potentially having the next uh birth uh extinct species what's that gonna be i'm not saying oh okay to be continued to be continued thank you ben yeah thank you okay ben so we just had i guess we just came from the lobby or so so we have something special in the room with us today we actually have something in the room yes So what are we about to reveal under the curtain? Yeah, so these are some of our woolly mice. These are some of our Gen 2 mice. So our successful woolly mouse project, which I think is objectively the cutest mice on the planet.

8:50Ben Lamm:These are offspring from that first generation. So they're not as probably famous as Chip and Dale were. But their offspring, you're going to see, are objectively as cute. And, you know, these are the second most genetically modified multicellular organisms on the planet after our dire wolves. So do we want to take off? Let's do it. Thank you. Oh, my God. Yeah. So, like I said, objectively pretty cute. They're very cute. Yeah. And so these mice, along our process to bring back the mammoth, you know, it takes 22 months to gestate an elephant. Elephants are endangered. You want to be very thoughtful in that whole process.

9:34Ben Lamm:So with these, you know, it's great about, you know, 21, 22 days of gestation is that you can actually test a lot of those core phenotypes or physical attributes in the editing. And so what was great about the first generation of the mice is we made them in 30 days. Like that kind of got lost in the shuffle, which kind of blew me away. It's like, so we had 100 % healthy mice born with exactly the predicted phenotypes with the most multiplex edited delivered at one time ever. And we did it in 30 days. So like the 30 day part got lost when we announced the woolly mice because everyone was just like talking about objectively how cute they were.

10:14Ben Lamm:but nobody really realized that it was done all in 30 days, which is amazing, right? So we took all of these edits that we'd been identifying for the woolly mammoth, identified the mouse equivalent of those, and then engineered them in in 30 days. And then birthed mice, right? So that's like crazy. So it showed that our end-to-end pipeline worked. You know, it broke the internet. A bunch of people talked about it online and talked about how cute they were. And it was a testament that the prediction of the exact edits in the mouse equivalent of those edits worked, which was amazing. That's crazy.

10:50And so I heard you guys have some super fans now. You have to keep everything under lock. Yeah.

10:55Ben Lamm:So our offices are open to the general public. But we had people that just showed up very excited about the mice, which then made us even more concerned about the direwolves. So, as you know, we don't have direwolves physically here because you would have seen them. But that's also one in the lobby animatronic one, right? Because people come and they're like, but where are they? That's why we have that like huge, like 60 foot screen showing like near very early screens. We probably are actually going to make that screen be a real time feed. So you can just see them in real time. But we but until we had the camera system worked up in high depth, we just are just putting that loop.

11:35Ben Lamm:And then we have the animatronic up there. So people could at least see the scale and the size. And we wanted to make something that was like Instagrammable when people showed up. Right. But yeah, having a giant 130 pound Pleistocene wolves in our in our Texas offices was probably a bad idea. But these guys obviously can fit much, much better here. And then we have an 8 ,000-square-foot vivarium that they all live in day to day. But, yeah, it is exciting, and people got very excited about the Woolly Mice. And we had to nicely remind people that we are not open to the general public. So you have to see everything on YouTube or a podcast.

12:13Ben Lamm:We don't invite people in often. And people have a—I'm sure you've gotten many requests for people to buy them. Oh, we get a request every day, right? There were people that actually made like legalized woolly mice t-shirts on Etsy, which is weird because they're not illegal. And then the crazy scientist in China that did the CRISPR babies, he like posted that they were bioweapons. What? I know. We got so many crazy things. We had people that bought woolly mice pillows. A bunch of bootleg, crazy ripoff products came out of it. And then even the Smithsonian reached out to us and said, hey, look, they're mice.

12:57Ben Lamm:Eventually, they're going to die. I mean, they were being realistic because mice don't have like 40-year lifespan, right? And they're like, could we taxidermy them and put them, when they die, on display? Because if you go to the Smithsonian or the Natural History Museum, you actually have that. So we've had a lot of weird requests. But we do get schools, museums. A lot of people ask to see them and ask for us to donate them and take care of them. We're not in the selling animal business. So therefore, it's not currently a part of our roadmap. Are you going to give them to the Smithsonian? I don't know.

13:32Ben Lamm:We haven't made any formal commitments. So if that's not the business model, selling animals is not the business model. What is the business model? I mean, the technology in these guys, I would argue, is probably the most revolutionary technology ever. There's a new term. We were in an article recently, and we did not admit this, but there's a new term called civilization tech. Have you heard this? No. Yeah, it's like, I think, the hot new thing. Wow, you created a new category. No, no, we did not. We're in it, right? Anthropic was in it. I think it's the evolution of the moonshot category, right?

14:05Ben Lamm:Whereas now that Elon's going to put a whole base on the moon and then Mars, I guess we can't call moonshots moonshots anymore. So I think this is this new category of technologies that have an application broader than their services or products for the market, but have a bigger ripple effect on humanity. And I think genome engineering at scale and full DNA synthesis at scale and artificial wombs at scale have an application that's like insane. Like when we were at the conference that we met at, they were like we had just done our capital rate, our last capital round. And people were like, yeah, this is a very big round for a company this early.

14:46Ben Lamm:And I was like, they're like, they made some comment. And I said, yeah, I do think that we are one of the most undervalued companies in the world. Because I truly do. The ability to preserve, engineer, and direct life on a planetary scale in all species, I think is a pretty important skill set for humanity. That's a really interesting point, though, on the size of your fundraisers. So the last one was$400 million. You've raised$630 million in total? Yeah,$635 total. The last round was supposed to be$200, and it got overscribed to$400. Not bad. Yeah, yeah. And we're just getting started. I'm sure we'll raise more capital.

15:24On that point, though, I was listening to a few of your podcasts ahead of this that you've done. You've done so many great ones. But what I think is underrated is what you use that capital for. It's not just the lab, but it's the preserve. It's the reserve.

15:39Ben Lamm:It's like school facilities. A lot of it goes into like the halo effect of the technologies are amazing. And what's interesting is we don't know what we don't know even about the business model. Like we know for a fact that there's government use cases around preserving life and building applications to different problem sets like invasive species. Right. So invasive species is like half a trillion dollar problem globally. It's huge. Right. Right. Think about like rats on islands. Think about, you know, the screw worm here in Texas, which is going to decimate the cattle industry. It's terrible.

16:17Ben Lamm:It's awful. And so like our choices are beef prices go through the roof. We inoculate our cows, which a lot of people don't want to do that. Right. Or we attack the invasive species. Right. And the best way to do that is a gene drive. It's engineering in a safe protocol that then goes through the population and makes them sterile so that there's no future generations. Right. If you are an animal welfare person around insects, which is great, there are those people, this is a good solution for you because we're not out there spraying. Right now, people are spraying chemicals. It's very, very bad.

16:55Ben Lamm:Same thing with Lyme's disease and ticks in the Northeast. People are literally poisoning the environment and poisoning other animals and plants to get rid of ticks because of all the negative effects. It's killing the moose population. It's killing deer. It's affecting people with Lyme disease. So there's all these huge problems around invasive species, right, that we as humans cause. And so using gene drives in biocontrol and biocontainment technologies to do that is like, you know, hundreds of billions of dollars, right? And most people don't realize that when they think about de-extinction, right, the technology set.

17:30Ben Lamm:Also, the technologies that we're developing that have applications to human health care are insane, whether it's individual pieces of the artificial womb for like IVF and embryo health, to be able to even going as far as like, you know, being able to germline, edit out certain disease states for genetic diseases and disorders. Right. So Colossal is the world leader in that. And so those are things that we know. But we didn't even know that three years ago in the last few years or a few months. We've had people come to us. There's a particular type of fabric that comes from a particular type of animal that's ethically harvested.

18:13Ben Lamm:But they literally buy billions of this from from this country. And they came to us and said, hey, we need to increase this by six X. And there's just not enough of these animals. Right. And so they're like, we're going to keep buying from this. But how do we also do five X more here domestically? And it's like we own the rights to the animals. They're like, well, can we clone these animals? Can we even productionize it where it's, you know, like lab grow meat? Can we do, we've done, I don't know if you saw this in the lab, but we actually have hair follicles growing in where we've taken elephant stem cells and created follicles so that we can grow mammoth hair.

18:50Ben Lamm:So what if you did plates and plates of that and did full warehouses of growing this without even touching the animals, right? So it's like the lab grown equivalent of hair, which is kind of weird and cool. But we're like the only company to do that. And they are buying billions of this and they want to 5X it. And there's just not that much available. Like three months ago, we didn't know about that. And now we're working on coming up with a solution to help them solve that. We've also had an extinct bird or semi-extinct bird and critically endangered bird that a lot of the Middle East wants to help bring back because it's important to their falcony and culture.

19:24Ben Lamm:So they've come to us and say, look, this is, you know, billions of dollars in terms of research and conservation that we spend and we just haven't been successful with our artificial eggs and other technologies. We can help productionize that. Right. And so these are the types of use cases that once people understand the capability sets of artificial wombs for mammals and avian all the way through genome engineering, computational analysis. You know, what's interesting is like we as we focus on our business model, it creates all these unique opportunities where people say, could you solve my problem with biology or genome engineering or artificial wombs?

20:01Ben Lamm:And so it's interesting that, you know, the plethora of opportunities we have is interesting. And I think that the hardest thing that we will continue to have is making sure that we stay focused on our core mission and don't deviate too much for some of these large economic opportunities. I'm sure you're going to get inundated with more, especially because of AI. We haven't done many biotech interviews, but now because AI is really converging with biotech, it's exploding. It is truly exploding, right? It's like you're going to see this pre-Cambrian explosion of new drugs and new therapies that all come from AI-assisted drug design discovery.

20:41Ben Lamm:One of our companies that we spun out called Astromech, which raised money recently and may or may not be raising money now soon-ish, this is going to sound crazy, is a different way of looking at drugs. It's using AI to build. It's a very focused model, so it doesn't need the breadth that a lot of these other models need, right? So we don't have to go build a$500 billion data center in computing power. We don't have to fight for water and other things that people are all upset about. We can be very, very focused, but it's looking at evolutionary trends to understand why over evolutionary trends do certain animals have certain conserved regions of the genome that prevent things like cancer.

21:24Ben Lamm:So if you look at a protein like p53 in elephants, elephants get cancer at about a rate of 2 % to 3%. Humans are about 24 % to 25%, right? And so they do that because that cancer suppression comes from an overexpression of P53, right? Well, we have the largest data set on elephants in the entire world. We actually have the largest data set of multiple species of herpes because EHEV is a herpes vaccine that kills elephants, right? So when you start to look at things of like why certain species have invulnerabilities to certain disease states, you know, that affects human health care, we can track that evolutionary trend over time and look in and even build like if you look at some of the prediction models out there, build a prediction model that can be applicable not only to like cancer evolution, but also things like bird flu and other things.

22:17Ben Lamm:And so what's really interesting is that while AI is critical to what we're doing at Colossal, and none of this would be possible without AI and a lot of the stuff that we've had to build is bespoke, we're now even applying it to kind of the next level of like drug and therapeutic design discovery. That's insane. All using like ancient genomes all the way through like the most recent genomes from even endangered species, which is crazy. Okay, one thing when we were walking through, like, I know this is kind of maybe a nerdy thing, but, like, I was just totally blown away by even the supply chain of everything that goes into finding the, you know, cells for these things, how they escape thousands of years, sometimes millions of years, that kind of thing.

23:05And then also, like, the pigeon eggs that you have.

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23:07Ben Lamm:Yeah, we have the pigeon colony and a bunch of strange things. We have a chief animal officer. We have like fresh pigeons that come from our, we have an avian facility. So these are things I never thought, because I come from mostly like traditional SaaS and software. And so I never thought I'd have any of these roles. You know, we have an incredible team that takes care of things like fully mice, right? And these are things that we have. But there is so much. And I think that's the value that we've built is we try to look at this from a vertical integration, first principles perspective of looking at, we had to own the entire stack, right?

23:43Ben Lamm:So that's why like when we were looking at expanding our endangered species production, our biobanking and BioVault initiative and kind of our global network that we've been rolling out, buying Viagen made a lot of sense, right? When you look at like animal cloning, most people it's dogs, cats, and horses. But there were like two. There was Viagen in the U.S. and then there was a company in South Korea. And so there was like really two. Well, Viagen had cloning efficiencies at 80%, where most people are at 2%. And so it made sense for us to say, okay, we need to buy them and bolt them on from a vertical integration perspective.

24:20Ben Lamm:So much of the supply chain, we've either built, innovated, licensed, or bought. But you got a taste of it. Today, we put the entire thing under one roof. And I think that cross-disciplinary function of allowing people to work, you know, from everything from animal ops to ancient DNA extraction in everything in the middle makes the products go faster and better. So we have to let our furry friends go. I know. They only get so much time. They only get so much time. The rest you have to pay for it. I'm just kidding. But we'll say goodbye to the little woolly mice and then we'll just continue after that.

24:57Ben Lamm:Great. This episode is brought to you by Brex, my favorite. You become what you spend on, and I refuse to spend my time on work that shouldn't exist. Expense reports, receipt chasing, and manual closes. The companies building what's next from Vercel, OpenAI, Anthropic, Granola, and Deepgram all made the same call. They all run on Brex. Brex is the intelligent finance platform that combines cards, expenses, and banking into a single stack. with agentic finance built in. AI agents that handle expenses automatically, enforce policy before spend happens, and close your books in minutes. That's why Sorcery runs on Brex, so I can spend time on building and not busy work.

25:43It's time to get Brex AF. Learn more at brex.com slash sorcery. That's B-R-E-X dot com slash S-O-U-R-C-E-R-Y. Bye. Turing is training the next generation of AI with tasks that require real expertise and real world judgment. That's why companies like NVIDIA, Anthropic, Salesforce and Gemini partner with Turing. Turing builds realistic reinforcement learning environments and data systems based on real operational traces. The kind of infrastructure frontier labs need to train superintelligence. Visit Turing.com slash S-O-U-R-C-E-R-Y. So to set the stage, you started this on the premise of extinction.

26:29So what are the stats? I know this is dark. No, it's super dark.

26:32Ben Lamm:It's like it's like but but like it's dark, but I think it's hopeful, right? Like I'm an eternal optimist. It's currently forecasted that we're going to lose up to 50 percent of all biodiversity in the next 25 years. So that's dark. Yes. But it's like that's why we have to do stuff. Right. And so for us, if we can get everyone, like sometimes people get confused that like we think that de-extinction is a replacement for modern conservation. We do not think that. But the reality is, is like no matter how good conservation works, it just doesn't move at the speed of which we're eradicating species and changing the planet.

27:11Ben Lamm:Like we're doing that. Like that is happening. So for us, if you have a combination of a de-extinction toolkit, as lots of other ramifications, which we've talked about some, and you get governments to invest in a global distributed biovault network. So they're at least backing up things. At least we're starting to build a backup plan. And then lastly, we open source all of our technologies for conservation. So anybody can use any of our technologies for free for conservation. There's a bad actors. Well, there's always going to be bad actors, right? And so you can't prevent that, right? That's like when, I don't even remember a decade ago when people were like, you can't, San Francisco temporarily put this moratorium of investing in facial recognition because China was doing some bad stuff, isolating populations using facial recognition.

28:01Ben Lamm:That doesn't mean facial recognition is bad. That just means people are going to use it in bad ways, right? But that doesn't mean that we shouldn't innovate the technologies for positive use cases, right? And so that's the way I feel about these technologies. These technologies are very, very powerful. And people are going to do all kinds of bad things probably with them. But that doesn't mean that we shouldn't engineer them and make them so that people can do good with them. I'm an eternal optimist, so I believe that we will ultimately do more, we as a species will do more good with them than that.

28:34Ben Lamm:And so open source them to the conservation community for conservation purposes. So if people use our technologies for nefarious reasons and not for conservation, then yeah, we would probably step in and enforce that. Straight to jail. I don't know if we have that power, but we would give them a lot of legal feedback. No, that's really interesting. So we were just talking when the woolly mice were here before you, and I forget her name. What's her name? Oh, Katie. Katie. So I was talking with Katie, and she was telling me how she got to here. I was like, how long have you been here for? She said she's been here for three years.

29:08She was at a zoo first, then she was at a clinic, and then she came over here and she was like, well, the conservation, preservation side of things is completely broken. There's literally no movement. Nothing's going on there.

29:19Ben Lamm:It's boring. Sometimes it's hard to, and we've had, like, at the beginning we had a lot of negative feedback on this. It's gotten to be, it was neutral. Now it's becoming, trending more and more positive. But the conservation community is actually some of the biggest at times that has been historically some of the most vocal critics of the work, because I think they view it early on is that we thought we positioned ourselves as a replacement for modern conservation, which we never did. We're like, no, no, no, you should do conservation work. Like, don't give us money. And we always view this as net new ideas, net new money, and net new technology, and net new awareness, right?

30:04Ben Lamm:Like, most people don't know that 20 % of baby elephants die because of EEHV. So people, like, should know that. And so if you go talk to any of our elephant conservation partners, they'll tell you that their funding has gone up since Colossal was invented. Damn. So, I mean, so I view it as a net positive. But in the early, to her point, in the early days, it did take some long conversations with that community because that community is very stuck in its own ways. But if you spend time with that community and you ask them, are we as a whole, as humanity as a whole, with current modern conservation techniques, are we winning the fight to save species?

30:46Ben Lamm:And they will all tell you no. So it's okay. So we've got to do something different. And so we argue that like 99 % of people should keep doing what they are doing with conservation and we're that 1 % difference. But wouldn't you rather have a de-extinction toolkit and not need it than need a de-extinction toolkit and not have it? Remember like Star Trek when like the aliens came and they're like, we don't have blue whales. And if we don't listen to, if we don't have the sound of a blue whale, like we're going to like destroy the planet. Do you remember this? Totally. Old school Star Trek movie.

31:18Ben Lamm:And it's like they had to go back in time and like like capture a blue whale and bring it to the future. So like the aliens didn't destroy us. Well, that's like, you know, we don't have that exact issue currently. At least I don't think there's a lot of UFP noise right now. So maybe they're looking for something. But but ultimately, I would rather have this technology set and not need it or at least use it in these interesting capacities that help individual species and help inspire the next generation. and get people excited about science. And I'd rather do that and never need it for a mass scale extinction event than have a mass scale extinction event, which we know we're in right now.

31:59Ben Lamm:We know that's happening. And then not have these tools. But I think I'm more pragmatic about this. I guess to put this into practice, one of the really cool things that I saw when we were walking through the lobby was with the dire wolf. If you see this, like this, you guys have this like little like model of like how land is evolved over time and the benefits of the dire wolf on the land and how biology changes and all this kind of stuff. So like in practice, are you going to be releasing any of these animals? Yeah. So in a couple of phases. So obviously you have to work very closely with governments, indigenous people groups, private landowners.

32:40Ben Lamm:For our extinct species, we do want to put them back into the wild with all these collaborations in place, right, where they help the ecosystem, the government supportive, indigenous people groups are supportive. We want to do that for our in for our gene drives and whatnot. That's also highly up to the government. Right. Like right now we are educating USDA, the intelligence community, the Department of War and others on these technologies and how they can combat these issues domestically and abroad. So but it is up to them. Right. Like they have to give us the green light. Like there are some there are some I did an interview about the screw worm that went viral.

33:20Ben Lamm:and there were like 20 articles about it. And then there was feedback on like Blue Sky of all places. Surprise, there was negative feedback on Blue Sky, right? The echo chamber, you know, or liberal Twitter, right? And so there was feedback on Blue Sky that's like, well, Colossal doesn't have permits. Yes, we do not have permits, but this is a technology that if it is permitted, can eradicate this problem. And so like in the screw worm example, it's like they're spending a billion five in taxes and in eight years, they're going to like slow or stop the problem. Our solution, which is already made, could eradicate the entire problem in every model that we've done in six to seven months.

34:02Ben Lamm:So we could save a decade in billions of dollars for taxpayers. And, you know, and also the animals that are going to go through this painful death from the screwworm, right? So like if you're a beef person, your price of beef is going to stay low. If you're an animal welfare problem person, well, then you're these animals are not going to be in pain from this terrible infectious disease that comes from the burrowing screwworm larva. Right. And if you know and if you're just a if you're somewhat fiscally minded, you're going to save the taxpayers money. Right. And so these are those these are those technologies.

34:39Ben Lamm:But once again, to put it back in the wild, we have to have support of the government. So our goal for our extinct species, our genetically modified gene drives, and even cloning of endangered species, all of that is to go into the wild. But we have to have government and indigenous and global support. Honestly, it's just so crazy. It's also really cool because you come from a real tech software background. You're already very successful. Well, this is, I mean, if you've seen other labs, it looks probably most like no other lab you've seen. No, I mean, it's beautiful. It's cinematic. It's like there's like, I mean, there's also fun stuff going on in the background of it.

35:17But I mean, it is there is very techie for a lab for sure. Yeah, it is.

35:21Ben Lamm:We look at this more as a product company in a tech company than a traditional biotech company. Right. Like we're not an academic lab. We're not a think tank. We're not a biotech that's going to just, you know, work on one solution. We have to innovate across the entire spectrum of the pipeline. And, you know, I think that you feel it here. There's a real sense of urgency towards the mission, which I think we have to have given some of the stats we talked about. Yeah. So how did you construct the organization? Having zero background in biology and biotech, I couldn't be more qualified to run this company.

36:01Ben Lamm:But we look at it as a systems model, right? Like extinction is a systems model. Genetic engineering from like taking a 73 ,000 year old skull and going to puppies is a systems model. And so taking that kind of approach and just asking the right questions and trying to fill in the right. Like what's great about this company and is also hard about this company is that there's not another one. Right. There's not another DXA. So there's not like it's not like here's your SaaS company roadmap. app, right? And so the good news about that is like, if we make mistakes, there's not really other people to be judged against, right?

36:40Ben Lamm:Because no one else had ever done it before. But the bad news is no one had ever done it before. And so we try to take a very rudimentary first principles, build from the ground up. How do we build complete vertical integration in how we thought through the design of the business? And we've reorg'd a couple of times internally. And I feel like we finally got the right momentum, you know, as a company. And I think you're starting to see that with more and more innovations that come out of the company. What does that composition look like? Lab, research? It's mostly scientists. So, you know, we have 260 plus people, plus 17 academic partners, plus 80 folks in academic labs.

37:23Ben Lamm:We also fund and about 95 advisors. And so, Oh, my God. I know. But they're tiered. So we have, like, scientific advisors, indigenous advisors, executive business advisors, and youth advisors, right? Because, like, they are – most people don't realize this. Everyone talks about our problems and how the youth are going to inherit the problems. They're also going to inherit our solutions to some of these problems. So when we are solving these problems, if we are solving it in dumb ways, like I think, you know, a lot of the air capture systems and other ways that direct air capture carbon systems and others in a lot of other ways that we're trying to solve climate are dumb.

38:01Ben Lamm:And so our but but if we invest, you know, a trillion dollars in that infrastructure globally and we hand it to our kids, our kids are going to have to then count. You have this like, you know, tech debt that comes with that. And so we've tried to think through how do we make a solution that not only are we proud of, but our next generation is. That's why having like a youth advisory board is like really helpful. Like getting their feedback to us is as important as our indigenous board or our scientific board. So it sounds like a lot of people, but we have different groups that manage each one of those external folks.

38:39It also seems like you guys are really popular with kids either way.

38:43Ben Lamm:Every decision we make, if you go to the highest level, we try to create value for our investors, right? So it's value creation, impact for the world, and inspiration. So for us, and we told our investors this from day one, that inspiration needs to be as important as value creation. And you need to be on board with that. Like, if we do the greatest thing in the world that nobody knows about, and like, you know, kids don't get excited about science, then we think we failed. And so we really try to put a heavy emphasis on kids and education. And we have this conversation with the scientific community a lot in some of the scientific journals is that like kids don't read nature and science themselves.

39:24Ben Lamm:Right. The ones that do. I don't know. Like those. Yeah. They should work here. But but they but like those the kids, the kids that make that that like read that are already committed to science. Right. Like that would be incredible. I can't. Some of these papers are really hard to read. But most people are like we're competing with pop culture for like the latest celebrity trend. And so you have to be able to communicate really hard things like CRISPR and some of these genome engineering tools and the impacts and positivity on the world and what they're doing today. And you got to do it in 20 seconds and you got to do it on Instagram.

40:04Ben Lamm:But I mean, but that's real, right? Because that's where the next generation is. that's how they communicate, right? Like what's our Snapchat strategy? Those are the things we think about. Today's episode is sponsored by VCX by Fundrise, the public ticker for private tech, allowing investors of all sizes to invest in venture capital. Learn more at getvcx.com. Some of you may not have heard this yet, but our sponsor public just launched something called Generated Assets, and it brings AI into investing in a way I've honestly never seen before. Here's how it works. You type in an idea like AI-powered supply chain companies with positive free cash flow or defense tech companies growing revenue over 25 % year over year.

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41:24Paid for by Public Investing. Full disclosures in the description. Founders scale faster on deal. Set up payroll for any country in minutes. hire anyone anywhere, get visas handled fast, and get back to building. Visit deal.com slash sorcery. That's D-E-E-L dot com slash sorcery. Well, so we should talk about your funding history.

41:47Ben Lamm:Yeah, sure. I can imagine that has evolved. Yeah, yeah. The story of a business model, like the early believers versus the ones that are backing up the truck now. Like, it's probably very different. Yeah, in the early, we were very thoughtful in the early days. Like we wanted to have a long term investors, technology focused investors, people that could that can look at like, OK, here, what is this event horizon? You know, 10 years, 20 years, 50 years out. Right. We were not looking for investors that were saying we want a fund return in four to five years in fund X. Right. Like those just weren't for us.

42:25Ben Lamm:We have some of those, but those were not our primary focus. Then we wanted a percentage of impact investors, like who are people that part of their internal KPI system that they track is around making positive impact. And so we really try to find the right balance. I think we did a really good job. Right. I think, you know, I think the most people would have said, oh, you should call Masa or SoftBank out of the gate. Right. Like that was kind of like I think how most people think about a business like this. But we haven't. Right. and we're big fans of what he's done. But some of those types of funds, we didn't go after.

43:01Ben Lamm:We said, okay, let's go for very thoughtful business people. Like, let's go to people like, you know, Jim Breyer. Let's go to people like Thomas Tull, Mark Walter, people that have built these legacy large infrastructure plays that have done stuff in education, in entertainment, in science, in technology, people that were early backers in the internet and quantum, people that understand what full new economies and systems can come from getting the entire pipeline. And so I think we were very, very thoughtful on that. And what's funny is I think that we've completely mispriced every single round of capital because every single round of capital has been more than 2x oversubscribed.

43:51Ben Lamm:So what I hear from that is we're cheap. Like we're not, we're a cheap date and we should raise our rates on capital. And so maybe we'll do that in the future. Don't sell yourself short. I think, yeah, but every round has been massively. So it makes me think that people are not just excited and see the vision, but in the impact, but they also, you know, I think they've also thought they've got a good deal. But this is not your first rodeo. I mean, you've had a successful exit. Yeah, yeah. I've been very fortunate to work with much smarter people than me to build a handful of businesses that have had successful, profitable exits.

44:32Ben Lamm:So I do think that helps. I think that helped in the early days, right, where it's like you've got, I think in the early days when we had a, like our original deck was like, we have no scientist. we have no partnership with Harvard um we have no technologies um and and we're a handful of software and hardware people that are pretty they have no background in biology and George Church thinks he can make a woolly mammoth and we're pretty sure that that's worth something like that was like the the original deck and the original the original deck was was that it was pretty bad. I mean, I'm being honest, I would have passed on.

45:11Ben Lamm:I talked to an investor that passed in the early days, got a very big fund and wants to get involved. And he was like, I just can't believe I passed on this. I was like, I would have passed on this. In all reality, I would have passed on this. Yeah. So how did you guys prove them all wrong? I think that trust, I think it's easy to raise capital when you have trust. And I think trust is built with setting and managing expectations. So we've, I think, done a really good job with our investor base and with hopefully the world and also our board of setting and delivering on expectations. And I think we've shown, we've had these surprise, like the Woolly Mice were a surprise and delight moment.

45:56Ben Lamm:The Dyer Wolves were definitely a surprise and delight moment. And so I think that delivering on kind of our roadmap, app, we've been very consistent on kind of our delivery and we've been ahead. And then I think we've also done a really good job of exceeding those expectations of what's possible. Like we were told if in five years we were doing five to seven edits, we'd be great. We're now doing hundreds of edits. We haven't done this yet, but we're now pushing a new construct that we've designed and a new delivery mechanism that we think we can be doing thousands of edits at once. Like these are things that like, you know, a year, like three years ago was like sounded impossible.

46:38Ben Lamm:A year ago still sounded impossible. Right. And so I think we're consistently showing that. And so when you build that trust, I think it's very easy for people to continue to deliver or to invest. I mean, we saw some lasers back there. Yeah, there's some lasers, right? Right. Like, yeah, the lasers thing is pretty cool. So but eventually even that was in our somatic cell nuclear transfer cloning lab. But that entire embryology thing, well, that will eventually all be automated. Right. So we've got the best embryologists doing the same thing every single day in multiple different clades of animals.

47:15Ben Lamm:So that, you know, in that screen that you saw, that's doing full time screen recording. So we're looking at the position of the laser. we're looking at the position, the O site, we're looking at the position of like how much DNA is extracted. That entire system, we had to go build that entire system. I don't know if they told you that on the tour. That's all custom. So we had to go build and innovate all of that hardware. But in the future, that whole process will be automated with robotics. So do you get like a report at the end of the day, at the end of the month? Like how do you learn and train off of the data?

47:49Ben Lamm:Yeah. So on that data, that's highly visual data. So it's all screen capture and computer vision from an input and capture perspective. We track efficiencies and cloning rates. And so we track all of that in spreadsheets. Now, thanks to some of the next-gen and applications of AI. In the early days, things like OpenAI and Claude and others weren't super helpful to our company because it's like, turns out that like, you know, Opus doesn't do like an ancestral state reconstruction of like a genome and like it doesn't like build comparative genomics models. So we had to go build all of that, which I think was good because we had to go build up an AI team and think through some pretty hard problems.

48:39Ben Lamm:But now we're connecting existing systems like, you know, most labs don't use things like Jira. And so I think the hardest thing we've done is reprogram not stem cells, but scientists to work in things like Jira and smart sheets, like traditional software like things. And then we're connecting those to like the lab notebooks and some of our proprietary systems all through an AI layer. And so the visibility that we can give our mid-level and senior management on the science teams of what's happening in the lab in near real time through the aggregation of AI across systems. Now we're implementing some of these systems, these existing enterprise AI systems at scale, where it's really, really helping.

49:25So you guys do, between that and the labs and how everything is designed here in this secret location. How did you get, I mean, you have a very distinctive style here. Like, how did you guys develop that style and the branding around that?

49:39Ben Lamm:So we wanted to make, once again, couldn't be more underqualified. We wanted to make, this kind of goes back to inspiration. We wanted to make science cool and fun and engaging. And so when we set out to do the task of, like, getting rid of extinction, sanction uh we wanted you know we thought it was a big problem so we thought colossal was a good name because it's a pretty big problem that we're trying to solve um and then at the same time we're also working with cells which we thought was funny that we're working the most small things but hopefully they're successful to make really big things so we're kind of planning success right with that with mammoths and stuff so so that's where we came up with the name but then we had this idea that it's like if you're going to go back to the like bill nye old school models of like science and excitement where it's like you're putting in the red food coloring and then shit's exploding in the volcano versus like today where it's like only spelling bee champions and like kids inventing like nuclear fusion if you want to go back to like the stuff that i could do like in in like the 80s and 90s well then like that's like old school mtv like back before it was like 16 and pregnant and it was like tRL like how do you go back to like the tRL days of MTV and mash that up with like the like robustness and thoughtfulness and scientific rigor of Harvard.

51:00Ben Lamm:Right. But that's boring and stuffy. So how do you take like Harvard meets MTV? That was like our thesis from like day one. And and I think we nailed it. Like I think the colors, I think the attitude. I mean, it's like when we walked in. But if I say if I said you randomly, if you had not been here or seen anything, Harvard meets MTV, you'd be like, that's just dumb. But now that I say Harvard meets MTV with everything you've seen, you're like, does it like, that actually describes exactly what you guys have built. So I'm very proud of that because we spend a lot of time in it and we want to evoke our brand in messaging.

51:41Ben Lamm:And we don't want to just say, oh, we have happy hours like once a month and we have foosball tables. We don't have food tables that are annoying and loud. That's why you see the murals. You see everything in there. We want to constantly remind not just the people that come here, but our staff. We have this unfair advantage of recruiting, being that you get to work on things like bully mammoth cells and done arts versus yeast in an academic lab. But also, after you work in this lab, go try working in another lab. Like go work back in academia where you're underfunded. It's all like massively politicized and it's massively competitive.

52:22Ben Lamm:And your labs are like held up by pizza boxes, right? Like go like, I chat, like go work in academia after you work here. It's like, you just don't see that. I mean, we are like technically, well, I can't say where we are but there's lots of medical buildings around us yeah yeah they don't feel like this though i know i would imagine they don't we know we accidentally walked into a few yeah because it's really hard to find yeah yeah this is good all right that's great that's the best thing i learned today yeah yeah um but i'm really curious okay here's a hard question i love hard questions what can you what's on the like the no-go list like what can you not make i listened to a few podcasts and one of them was like ironically the t-shirt that i'm wearing is what we can't do really yeah so this is this is giant epithecus which was like not king kong but not an existing ape it was like it was like a giant so we're not worried we will not work on anything related to our technologies can be applied to human and we can spin them out and license them but we won't do the human work here right like i made the joke before but we don't want to have like Colossal launches a hair solution and then people were like, is that mammoth chip that people are putting on us?

53:38Ben Lamm:Like we don't, we never wanted that. And so like we already have people that there's a fringe group of people that already have some like crazy conspiracy ideas about us. So I don't want to encourage that. Oh, that we're a secret government. I mean, the list goes on. I don't think a government lab would be like this cool. No, right? Right. And so that's part of the cover up. Yes. And so the it says we have that kind of we've all kinds of weird things. People have assumed that we like like we actually had a very critical group of from this one publication that's New York based. That is just weird.

54:22Ben Lamm:And they like to be critical on lots of things. And they were here, and at the end of it, they were like, do you secretly have a mammoth that you're not telling us about? I was like, no. Why would we do that? So there's all kinds of weird stuff. So we won't work on humans here because we've been asked the Neanderthal question. And so non-human primates in over we won't work on, right? Giant epithecus would be amazing to see. But we're not going to do that. There was this crazy time. That's where we were all on. You did this crazy interview with Ashley Vance. Has he come in here yet? No. So I did.

54:59Ben Lamm:So I've done it weird. It's crazy that you just said this. Okay. So I did his, I think I was his first podcast. Really? When he left and he did his first, I think I was the first episode or like. In his studio? Editor mode. Yeah. But he literally messaged me like a week ago. And so we're catching up. He has crazy. I mean, he's seen some crazy shit. Oh, yeah, yeah. Like you went with George Church to like, you know, whatever land. And you've seen drawers with like lots of stuff in them. But he like went to Russia or like Serbia or something. Some, I don't know where it was. Some cold place over there.

55:36And there was this like mad scientist dude who was like, I guess, a chill guy. But he had like human heads in a cold locker and all this stuff. I'm like, Ashley, you weren't there.

55:46Ben Lamm:Yeah. What? He's like, yeah, that was the craziest interview I ever did. I'm like, oh. We'll work to top it next time he's here. Or he hasn't been here, but when he comes. But yeah, he's great. And we did his podcast. And I didn't know him before that. Yeah. And he was awesome. And then we just reconnected, like, literally in the last week. He's great. Yeah, he's great. But yeah, there's up in some weird stuff. But that's like synthetic biology. I don't think this is what people realize is that the intersection of AI and compute, eventually quantum, and synthetic biology, like, it will transform everything.

56:20Ben Lamm:Like, you know, we will have a point where we can like George and I have like got asked this question. Like we were on some weird whose podcast was that? I think it was it may have been Adam Draper's podcast where he was like, if you and George could do one thing, what would it do? And we both talked about how we have this weird idea that eventually we will be able to program into trees. uh like how like can you build like a redwood that actually grows in the form of like a house and then like we go in down this like really weird like mushroomy hippie thing yeah and and like and like i think it was even too weird for adam draper he was like okay um mammoth he like completely george and i were like but i think that's going to be the power of synthetic biology is like the idea that we can like program life in whatever image we want is pretty amazing.

57:16Ben Lamm:And like we're advancing it, I think, further than anyone. But at the same time, we haven't even scratched the surface of what's going to be possible. Any megalodons? So this just shows how like fucked up the world is. Dinosaurs is request one. Megalodons is request two. Well, you have a megalodon room. I do have a megalodon room. But that's because it's like a... It's really cool. It's a really cool room. But it's like a fish tank, right? So it's like a fishbowl. So you got to like, you know, thematically do something. There is no Megalodon DNA. And if there was, it would be terrible to make...

57:55Ben Lamm:I mean, the ocean is scary enough, but we do get the request of Megalodon quite a bit. We're not working on Megalodon. Okay. Well... There's no secret like U.S. Navy anduril mashup for megalodons. They don't ask you to do your work on aliens? No, no. You can't just close that? That's another thing that we get, right? Really? Because I've been weirdly tangentially connected to the UAP crowd for a long time. For pre... Like I had a satellite company. No, no. But I like know a lot. I really don't. And then did some imaging work for Army Space and some other stuff in a previous company. And, like, I'm on the UAP Scientific Advisory Board for Avi Loeb.

58:38Ben Lamm:And so I understand why people draw the conclusion. It's not reasonable. There's some easy dots there. There's some easy, easy dots. But so people think that, like, part of, like, one of the other conspiracies is, like, the advancements in genome engineering has come from us studying, like, which is just not the case, which is just crazy talk. I'm glad you clarified that today. Yeah, it's crazy talk. So we get, there's a lot. But you could spend an hour just on weird, like, Reddit, like, conspiracies around Colossal. That's fun. It's fun. And we should do that some of those fun. Okay. Well, Ben, that leaves us.

59:12We're out of time. Yeah. Thank you so much. This was so much fun. The tour was insane. Yeah, good.

59:17Ben Lamm:I'm glad you came. I was actually a little concerned walking from the tour into here because I'm like, my mind just kind of exploded. Yeah, good. I love that. That's awesome. So thank you. I'm glad you came. Cool. Hey, it's Molly. If you enjoy our interviews, check out our newsletter, sorcery.bc, where we deliver a once a week top deals and tech headlines email and also go deeper on our podcast interviews. Subscribe to Sorcery today. And don't forget to subscribe to the podcast on YouTube, Spotify, Apple or wherever you listen. Link in description to sign up.

From the publisher

Ben Lamm is the Co-founder and CEO of Colossal Biosciences + their AI spinout, Astromech. Colossal is the $12 billion de-extinction company using genome engineering, AI and reproductive technologies to bring extinct species back to life, while Astromech is its AI biology spinout, now valued at $3.8 billion.

We went inside Colossal’s lab to see its Gen 2 woolly mice and sat down with Ben to discuss the technology behind the dire wolf, the race to bring back the woolly mammoth, and the much bigger business being built underneath de-extinction.

Colossal has raised $635 million, including a recent $400 million round that was originally targeted at $200 million. Ben explains why he still believes Colossal is “one of the most undervalued companies in the world,” and how technologies developed inside the company are creating entirely new businesses.

Astromech, the AI biology spinout Co-founded by Lamm and George Church, just raised $20 million at a $3.8 billion valuation, bringing total funding to $60 million. Astromech is using evolutionary and multispecies genomic data to build AI models designed to predict biological change, with potential applications across cancer, disease and drug discovery.

We cover Colossal’s rise, woolly mice, dire wolves, mammoths, artificial wombs, genome editing, AI and biology, Astromech, and what happens when humans learn to program life.


Ben Lamm: https://x.com/BenLamm 

Molly O’Shea: https://x.com/MollySOShea 

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𝐓𝐈𝐌𝐄𝐒𝐓𝐀𝐌𝐏𝐒

(00:00) Ben Lamm, Co-Founder & CEO at Colossal Biosciences 

(01:07) Inside Colossal's De-Extinction Lab

(06:02) The AI idea that could save the planet

(08:28) Revealing Colossal's woolly mice

(10:49) Wild requests they get every day

(13:35) Colossal's business model

(15:07) How Colossal raised $635 million

(20:17) How AI is converging with Biotech

(22:44) How ancient DNA actually gets to the lab

(26:24) The real stats behind Mass Extinction

(32:07) Will their animals ever live in the wild?

(41:44) Choosing their earliest backers

(52:51) Why they refuse to work on Humans

(58:07) Are they secretly working on Aliens?

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