Ebola Risks, Ferrari’s Luce, & Pope Leo’s AI Warning 5/26/26

26 May 2026 · 29 min · 14 chapters

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In short

Squawk Pod episode covering (1) Pope Leo’s first major teaching/encyclical on AI and AI risk/regulation, (2) Ebola outbreak risk assessment and potential treatments, plus brief market/industry updates (Ferrari’s first fully electric “Luce,” and Massachusetts rideshare driver unionization; Iran/U.S. tensions are also discussed).

Guests and backgrounds

Sebastian Malaby, author of The Infinity Machine (AI and Demis/DeepMind); Dr. Scott Gottlieb, former FDA Commissioner and CNBC contributor, board roles at Illumina, Pfizer, UnitedHealth; (also mentioned as Vatican co-presenter) Christopher Ola, Anthropic co-founder and safety researcher.

Key claims

AI is “existential,” could normalize an anti-human vision, and political consequences may exceed labor-market effects; open/proprietary model release needs tighter safety controls than open source; Ebola’s earliest cases may date to March, spread for months before detection, and U.S. risk is low but West Africa is the major threat.

Notable examples

Ebola strain Bundibouja vs Zaire (2014); possible therapeutics include MAP Biotherapeutics’ MBP134, Gilead’s obeldesivir, Merck’s molnupiravir, remdesivir, and Zaire-era Regeneron antibody cocktail; Pope’s AI warning presented with Anthropic; Ferrari Luce (Johnny Ive partnership) and Massachusetts Uber/Lyft driver unionization (nearly 70,000 workers).

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

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Tensions in Iran and U.S. Military Actions

0:36 to 0:59

Discussion of the escalating tensions in Iran and recent military actions.

“including projected stock updates, monetary policy decisions, and key results and statistics that may impact your trading.”

Tensions in Iran and U.S. Military Actions

2:07 to 4:00

Discussion of the escalating tensions in Iran and recent military actions.

“Welcome to Squawk Box right here on CNBC.”

Economic Implications of U.S.-Iran Relations

4:00 to 5:50

Exploration of economic impacts and political dynamics in U.S.-Iran negotiations.

“I just, you know, they've been a thorn in our side for so long and they're so annoying the way they pretend to come to the table and then talk tough.”

Pope Leo's Warning on AI

5:50 to 8:02

Analysis of Pope Leo's encyclical addressing the risks of artificial intelligence.

“But that's why I don't understand why we publicly come out.”

Ferrari's New Electric Vehicle Launch

8:02 to 10:40

Overview of Ferrari's first fully electric vehicle and its features.

“He suggested that the risk as humans will be reduced to what he said are mere cogs in a system driven towards ever greater efficiency.”

Unionization of Rideshare Drivers in Massachusetts

10:40 to 11:45

Discussion on the recent unionization of rideshare drivers and its implications.

“Drivers for ride-hailing apps like Uber and Lyft have unionized in Massachusetts.”

Upcoming Interview with Sebastian Malaby

11:45 to 12:49

Preview of the discussion with author Sebastian Malaby on AI and innovation.

“In places like New York City, it probably wouldn't change the dynamic much.”

Interview with Sebastian Malaby on AI and the Pope's Message

13:44 to 14:00

Discussion with Sebastian Malaby about AI risks and the Pope's recent encyclical.

“To realize the future America needs, we understand what's needed from us.”

AI and the Pope's Warning

14:06 to 21:46

Discussion on Pope Leo's warning regarding AI and its implications for humanity.

“Pope Leo warning about the risks of AI, saying it threatens to normalize an anti-human vision.”

Ebola Outbreak Concerns

22:39 to 28:00

Analysis of the ongoing Ebola outbreak and its implications for public health.

“at schwab.com slash market update podcast or find Schwab Market Update wherever you get your podcasts.”
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Exploring Anti-Cancer Drug Effects

28:00 to 29:56

Learn about the potential anti-cancer effects of new drugs and their mechanisms.

“They obviously need to be replicated in prospective studies right now, which are underway.”

Ebola Therapeutics and Vaccines

29:56 to 31:19

Discover the latest developments in Ebola therapeutics and vaccine programs.

“And the other point I'd make is Regeneron's approved antibody that was approved for the Zaire strain of Ebola.”

Health Insights from Dr. Gottlieb

31:19 to 31:32

Hear Dr. Gottlieb's thoughts on pandemic worries and health trends.

“You're our own AI chatbot when it comes to all things health.”

Health Insights from Dr. Gottlieb

32:25 to 32:45

Hear Dr. Gottlieb's thoughts on pandemic worries and health trends.

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Transcript

Automatic transcript. May contain errors.

0:00Sebastian Mallaby:At Venture Global, we think about what can be done, not what's usually done. Through innovation, Venture Global is not only building some of the largest energy facilities in the world right here in the United States, but delivering American energy at a fraction of the cost in a fraction of the time. So while others are busy talking, we're busy building. That's Venture Global. That's unstoppable energy.

0:30Dr. Scott Gottlieb:This episode is brought to you by Schwab Market Update, an original podcast from Charles Schwab. Join host Keith Lansford for this information-packed daily market preview delivered in 10 minutes or less, including projected stock updates, monetary policy decisions, and key results and statistics that may impact your trading. Download the latest episode and subscribe at schwab.com slash marketupdatepodcast or find Schwab Market Update wherever you get your podcasts. Bring in show music, please.

1:03Sebastian Mallaby:Hi, I'm CNBC producer Katie Kramer. Today on Squawk Pod. Pope Leo is bridging the Vatican and Silicon Valley with his first major teaching on AI. Author Sebastian Malaby breaks down the risks and regulation laid out by the head of the Catholic Church. This is not just a normal technology. This is not a shopping app. This is existential. Where humanity fits into innovation. The political consequences of AI disruption could exceed the actual labor market effects. And gauging the Ebola risk with former FDA Commissioner Dr. Scott Gottlieb.

1:40Dr. Scott Gottlieb:The earliest cases may have been in March. So this has been spreading for a very long time before it was ultimately detected and they started to take actions to try to mitigate further spread.

1:49Sebastian Mallaby:Those conversations today, plus Ferrari's first fully electric vehicle, a formal union for rideshare drivers, and the latest in the Middle East.

1:57Dr. Scott Gottlieb:If I were Ron at this point, I wouldn't be talking so tough. I really wouldn't.

2:03Sebastian Mallaby:It's Tuesday. Yes, Tuesday, May 26. Squawk Pod begins right now.

2:09Dr. Scott Gottlieb:Stand Becky by in three, two, one. Cue, please. Good morning, everybody. Welcome to Squawk Box right here on CNBC. We are live from the Nasdaq market site in Times Square. I'm Becky Quick, along with Joe Kernan and Andrew Ross Sorkin. Happy Monday, sort of. Happy Tuesday, even better. Nice. It's Tuesday. It's like a hybrid. First day of the week, but only three more to go. That's the thing. That's a four-day week. that is. Meantime, tensions are high in Iran this morning. This after the U.S. military sank two Iranian Revolutionary Guard ships that it said were attempting to lay mines in the straightforward movies.

2:49Dr. Scott Gottlieb:Now, yesterday, Iran responded by launching surface-to-air missiles at U.S. planes. The U.S. then struck back at a missile launcher. A spokesman for the U.S. command said that the United States, quote, continues to defend our forces while using restraint during the ongoing ceasefire. Now, Yesterday, President Trump said on Truth Social the negotiations are proceeding nicely, he called it, and that it would either be a great deal for all or no deal at all. Of course, this comes after our sort of Friday. I don't know what we're going to call it, Friday head fake, but an attempt on Friday to tell the world that a deal was in the offing and was done.

3:28Dr. Scott Gottlieb:That seemed to get a rebuke from a number of senior Republicans and has set all of this into a real new question all over again. The minute I start feeling like one of those Republicans, more hawkish, it's like, finish this. You went this far. You know, the 60 day concession to talk about the nuclear. Then I immediately think, oh, my God, I'm a neocon. And, you know, I'm ready to just jump in and just immediately. So I don't know how to feel about it. I just, you know, they've been a thorn in our side for so long and they're so annoying the way they pretend to come to the table and then talk tough.

4:11Dr. Scott Gottlieb:And then we don't know whether there are factions over there that realize midterms are coming up and want to wait and talk about, you know. You don't think they realize that? Of course they realize that. I said they do. We know that they're over there playing us and playing the whole thing. But then there may be much more moderate, perhaps reasonable people that we don't even know about that we are negotiating with that are saying you can have this stuff and you can destroy it. If you listen to the hardliners, they aren't even discussing giving us the 962 pounds. Overnight that there are no safe American bases in the region was the additional record that came out with this.

4:56Dr. Scott Gottlieb:But I will say both sides seem to not be pushing further in terms of taking the next step after this attack, counterattack. Lifting sanctions, war reparations, you know, all these things that were if we're even talking about getting to that point and then taking 60 days to decide to get a final answer on the nuclear material. That just seems like we're giving them way too much. But then again, like I say, I don't want to act like a war bonger that, you know, some neocon that all he wants to do is. It'll take 30 days, even from an agreement being reached before the strait is reopened. And possibly longer with the insurance pieces and other things.

5:40Dr. Scott Gottlieb:I mean, I think there's a sense. And they're saying they're going to still control it. Months and months and months. And it's our strait. And that's all. Charge a toll. What we're saying that they're saying is different than what they're saying. Yes. But that's why I don't understand why we publicly come out. Because it may be the hard line. Well, because it's because what hope springs eternal for a good outcome. But we've been told we've been told now, I don't know, half a dozen dozen, more than that. Right. That a deal is done. The straight is open. It's all finished. It's figured out. Like what surprised me was the reaction in the oil markets overnight again.

6:14Dr. Scott Gottlieb:WTI being down more than eight percent last week. And then it was down to ninety dollars overnight. You know, pick back up to ninety two forty seven. But nobody wants to. Yeah. And something it could be a an outcome that's what are we 13 weeks in or is it even longer? Yeah, there could be a. An outcome. That's favorable. I mean, if I were Ron at this point, I wouldn't be talking so tough. I really wouldn't. I would not be talking so tough. Put yourself in their shoes for a second. You really would not be talking so tough. No, I wouldn't be talking so tough. I'd want this over. and I'd care about my people.

6:53Dr. Scott Gottlieb:You're lucky enough to be in power still, that regime. And I just wouldn't, you don't have the same bluster that you had six months ago when you had all those drones and all those missiles and all those. I'm not sure that's the case. Well, this has always been your viewpoint, but that's, you know, that's. By the way, which has been the right viewpoint thus far? It's not been four or five weeks. Dow hit another new high. I mean, has that been your right viewpoint? I didn't talk about whether the Dow is going to go up or down. I never did. You go back and look at the tapes. I never tell you what the stock market is doing, ever.

7:30Dr. Scott Gottlieb:You didn't predict seven months ago a 30 % rise in the S &P. We're talking crashes and all kinds of things. I didn't say we were going to have a crash. Think how great it would have been if you said, you know what? I'm really thinking. Really bullish. Yeah. That would have been good, too. That would have been a change. If you told everybody to buy stocks, that would have been good for you, too. I've always been telling people to buy stocks, basically. And Bitcoin. In the meantime, Pope Leo issuing a warning about artificial intelligence. He said that it threatens to normalize, in his words, an anti-human vision and said that the concentration of immense digital power in the hands of a few private actors must be countered.

8:12Dr. Scott Gottlieb:He suggested that the risk as humans will be reduced to what he said are mere cogs in a system driven towards ever greater efficiency. At the presentation of the documentation, which is known as an encyclical, the Pope was accompanied by Christopher Ola, a co-founder and safety researcher at AI firm Anthropic. And shares of Ferrari are falling. On Sunday, the company unveiled its new electric speedster. The Luce is named after the Italian word for light. You think it's the color, Sorkin, that maybe wasn't so? I like the car. It's an EV, I guess. It's$600 ,000, isn't it? It was designed in partnership with longtime Apple designer Johnny Ive.

9:00Dr. Scott Gottlieb:It looks like an EV. And that looks like one of those ones that look like Thomas, a tank engine. The starting price,$640 ,000. It's the first Ferrari with five seats. It accelerates from zero to 60 in less than 2.5 seconds with a top speed above 190 miles per hour. God, that looks like a Toyota RAV. It can travel roughly 330 miles on one charge. And Ferrari CEO spoke to our colleagues at CNBC Europe earlier this morning. We invested a lot of money. We invest the right amount of money. We are focused. We are disciplined. We use the capex in the right way. I think that we invest the right amount of money.

9:46Dr. Scott Gottlieb:And this initiative, this business initiative, is in line with the profitability that we have also for other initiatives in the same range. So when we use capex and use opex, we use wisely. And the car has its own engine roar, which is made by deliberately amplifying the natural sound of the electric axles to the street. Is that like a whining sound? No, it's fake. It can also be amplified in the cabin in performance mode if you need the sound. Well, I will say I still have the sound of the shutter click on my camera, which is totally fake from this. Because I can't stand not having the sound there.

10:31Dr. Scott Gottlieb:It drives me nuts to not hear. To not have the, oh, you're saying you keep the sound on. Yeah, I keep the click, even though it's manufactured and fake. It's how you know you're taking a picture. Shutter click. Mine still does that. Yeah. Drivers for ride-hailing apps like Uber and Lyft have unionized in Massachusetts. Now, the app Drivers Union says it will represent nearly 70 ,000 workers in the state who now have the power to collectively bargain. and they won the right to unionize in November of 2024 through a statewide ballot initiative. Uber said it would work closely with the union drivers and the state government.

11:06Dr. Scott Gottlieb:Lyft saying it was committed to engaging in good faith. And of course, this is important because we will see whether the effort to unionize in other states comes to fruition. There was a big effort, of course, in California and other places before and how that changes ultimately the economics of all of these businesses. What if you connect the dots? What's the worst case scenario? If it goes over, it's bad. Is it not? It depends. We just had a whole conversation about the dignity of work and the church and about what it means to employ people and all of that. It will change the whole ride. It would likely make it much more expensive.

11:44Dr. Scott Gottlieb:I mean, to drive. Yeah. In places like New York City, it probably wouldn't change the dynamic much. But in other states and other parts of the country, it would, because the truth is the rates are actually pretty low. And Uber and Lyft are taking a pretty nice chunk of that number. Some of those people, of course, are working part time doing this sort of on the side. And then there's other people who are doing this is now a full time job. And should they be getting the equivalent of full time benefits and the equivalent of what it would look like to be a full time employee or not? I live in the real world, though.

12:23Sebastian Mallaby:Cheese will be next. Coming up on Squawk Pod, we're unpacking the Pope's encyclical on artificial intelligence with author Sebastian Malaby. The risks of innovation and the tech personalities in charge. It's not true that they're motivated just by profit. They're motivated by something more crazy, which is power, the sense of having humanity's destiny in your hands. We'll be right back. At Venture Global, we think about what can be done, not what's usually done. Through innovation, Venture Global is not only building some of the largest energy facilities in the world right here in the United States, but delivering American energy at a fraction of the cost in a fraction of the time.

13:08Sebastian Mallaby:So while others are busy talking, we're busy building. That's Venture Global. That's unstoppable energy.

13:43Dr. Scott Gottlieb:Or find Schwab Market Update wherever you get your podcasts. To realize the future America needs, we understand what's needed from us. To face each threat head on. We've earned our place in the fight for our nation's future. We are Marines. We were made for this.

14:05Sebastian Mallaby:Welcome back to Squawk Pod from CNBC. Here's Andrew Ross Sorkin.

14:10Dr. Scott Gottlieb:Pope Leo warning about the risks of AI, saying it threatens to normalize an anti-human vision. He invited Anthropoc's co-founder, Chris Ola, to present alongside him. Joining us right now, Sebastian Malaby, Paul Volcker, Senior Fellow for International Economics for the Council of Foreign Relations. He's the author of multiple books, including a great new one called The Infinity Machine, about Demis and Deep Minds and AI, and you are like the perfect person to talk to about this situation with the Pope and what the Vatican was saying over the weekend. What did you make of what he said? Were you surprised, by the way, that Anthropic was like right there as part of this?

14:52Sebastian Mallaby:Classic Anthropic, right? They're always reaching out and being the most keen on safety. And if somebody is going to say that AI, as it's currently configured, it's going to delight domination, exclusion, and death. which is what the encyclical says. Right. There'll be somebody from Anthropic there to listen and to say this is an important statement.

15:11Dr. Scott Gottlieb:What do you think the rest of the Valley is thinking right now?

15:15Sebastian Mallaby:It's funny, you know, I mean, I think they know that there's this huge backlash, right? And this is an extra dimension of the backlash because the classic backlash is jobs. It is my kids, their education is going to be messed up by these LLMs. you know it's uh maybe you know a sort of sense of a sense of but this is existential so i guess that's the difference thing this is the pope saying humanity itself is being challenged by a new form of intelligence and there are all these debates about is machines can they be conscious you know we used to talk about um the rapture in religion now we talk about the singularity um the idea of the afterlife this is transhumanist idea you upload your brain to a computer there are all these religious overtones to the AI language.

16:02Sebastian Mallaby:And maybe that's also part of the backlash. It's creeping people out. And that's what the Pope is articulating.

16:07Dr. Scott Gottlieb:But when you think about the folks at Anthropic, or by the way, even Sam Altman early on and others who've talked about sort of the real dangers that this technology poses. Demis has talked about the dangers. Is that a marketing ploy to sort of prevent, or they thought it was going to sort prevent the pushback later? Is that real to you? What do you think this, what is this?

16:30Sebastian Mallaby:No, look, I think it's totally real. If you take Demir Sasabes as an example, he founded his company after going to a safety lecture in 2009 by his co-founder Shane Legg, at which it was predicted that humans would be threatened by machines around 2030. And so this idea that this is not just a normal technology, this is not a shopping app, this is existential, And this is foundational to how these tech founders think about it. And it's not true that they're motivated just by profit. They're motivated by something more crazy, which is power, the sense of having humanity's destiny in your hands.

17:09Sebastian Mallaby:It's even beyond the 21st century version of the nuclear material.

17:13Dr. Scott Gottlieb:That's what I was going to say. The whole idea that in order for this to be safe, you have to keep it open source. He's kind of pushing back on that. The idea that there should be any open source, I think he thinks is a little crazy. And maybe you do, too, because would you do an open source nuclear project?

17:28Sebastian Mallaby:No, exactly. I mean, I think open source is the biggest miss by both the Biden administration and the Trump administration. Nobody is willing to say this is too dangerous. There was just some research out recently where some people took hold of the open source models, both from Google DeepMind, the Gemma series, and the meta models, which are open source. and showed how you could remove the guardrails super easily and then ask it to talk to you about chemical weapons and how you would make them. So this is way too dangerous. We have mythos. That was proprietary. It was restricted proprietary. Only 40 institutions got it, right?

18:08Sebastian Mallaby:That's where we're moving to. That's where we need to move to, is being very careful about how we release this stuff. An open way where everybody can do whatever they want, nuts.

18:16Dr. Scott Gottlieb:You've studied Google at great length, given your book about demos. They just came out with some new models last week. I'm curious if you wanted to stack ranking them for the viewer right now in terms of how you think about where Google really lays in this game versus where Anthropic is versus where you think Sam Altman at OpenAI is and maybe even where Meta is right now.

18:39Sebastian Mallaby:Yeah. So I think Google is sort of the second placed runner that always ends up winning. Right. OK. You know, it did not come out with Chatty PT first. It did not come up with agentic models as quickly as Anthropic. It did not do coding genius as quickly as Anthropic. But it comes from behind. It's got so much resources. You know, Google's profits just since 2022 have doubled. They are monetizing this directly. They are turning it into clicks and to, you know, click rates. They are charging. Not only has the click rate gone up, they are charging more per click because the clicks are more valuable with AI embedded in search.

19:16Sebastian Mallaby:You know, it's more accurate in terms of what people want to buy. So Google is just like minting money. And they've got a deep scientific bench. They have this enormous surface with consumers. You can serve them through search, AI mode, AI overviews. More than a billion people.

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19:31Dr. Scott Gottlieb:And they're about to be able to do that with Apple in terms of all of the phones. So how does that change things?

19:36Sebastian Mallaby:Well, I mean, it's already embedded in the Android phone, the Gemini system, as the Google model. As you say, it's going to be in the Apple phone. Now, everybody's cell phone in the world has, you know, Google first. Yeah, they're winning, right? Not in a flashy way of having the best science at all times, but in a kind of commercial way of getting it to more people.

19:56Dr. Scott Gottlieb:And then finally, I wanted you to weigh in on what we were hearing late last week, which is just that the cost of tokens is so high and probably going higher. Right. That there's a conversation, at least at Microsoft and some other places in the Valley, that maybe we're spending too much on tokens. Maybe it's actually cheaper for us to actually use humans to do our programming and coding and things like that.

20:17Sebastian Mallaby:Yeah, but you could use Gemini 3.5. That's the new model from last week. And its great selling point is that it's fast and very cheap relative to some of the other frontier models. So, you know, again, I mean, look, I hope that humans don't get displaced en masse really fast because that's going to be horrible. And I support a tax on capital and less tax on labor to try to even out that balance. But, you know, the frontier models are super expensive, but you can go to Google.

20:45Dr. Scott Gottlieb:Do you want to weigh in, Ripley? David Solomon, CEO of Goldman Sachs, had an op-ed. I don't know if you saw it. I did. Saying that the AI apocalypse is not going to happen.

20:53Sebastian Mallaby:Yeah.

20:54Dr. Scott Gottlieb:It's overdone.

20:55Sebastian Mallaby:Yeah. Another oracle who seems to know the future. I mean, look, it's super difficult. It's about the pace of disruption, right? I mean, and the other thing is the political consequences of AI disruption could exceed the actual labor market effects. If you think about the China shock, when China entered the WTO, over a 12-year period, there was a grand total of 2 million jobs lost because of Chinese trade. It's not very many in an economy which churns the whole time at massive speed. And yet, huge globalization backlash. And we could say the same with AI. Maybe David is right that we create as many jobs as we destroy.

21:34Sebastian Mallaby:But even so, I think the political backlash is a threat to these companies. It's a threat to being able to monetize the capex that they are doing. It's a question over the IPOs that they want to do. I think it's pretty important.

21:46Dr. Scott Gottlieb:Okay, Sebastian, thank you. It's a great book. Go check it out. Thank you.

21:51Sebastian Mallaby:Next up on Squawk Pod, is there anything weight loss drugs can't do? Former FDA Commissioner Dr. Scott Gottlieb joins us on the power of GLP-1s in cancer treatments.

22:02Dr. Scott Gottlieb:I think there could be something real here. You know, the drug is impacting overall metabolic well-being. On top of the idea that if you're losing weight, you would probably naturally be less prone to cancer.

22:14Sebastian Mallaby:Never bet against American grit or American energy. Through innovation, Venture Global is not only building some of the largest energy facilities in the world right here in the United States, but delivering American energy at a fraction of the cost and a fraction of the time. So while others are busy talking, we're busy building. That's Venture Global. That's Unstoppable Energy.

23:06Dr. Scott Gottlieb:at schwab.com slash market update podcast or find Schwab Market Update wherever you get your podcasts.

23:12Sebastian Mallaby:To realize the future America needs, we understand what's needed from us. To face each threat head on,

23:20Dr. Scott Gottlieb:we've earned our place in the fight for our nation's future. We are Marines. We were made for this.

23:31Sebastian Mallaby:You're listening to Squawk Pod.

23:33Dr. Scott Gottlieb:Welcome, Becky. Thank you. Welcome back, everybody. The number of Ebola cases continues to rise, along with concerns about budget cuts making the United States more vulnerable to diseases like this. Joining us right now is former FDA Commissioner Dr. Scott Gottlieb. He is a CNBC contributor and he serves on the boards of Illumina, Pfizer and UnitedHealth. And Scott, let's talk this through, because already I think it's over 900 cases, over 220 deaths. This is already the third largest outbreak of this disease in history. What happened? How did things get so out of control so quickly? Right. Well, this is with a new strain of Ebola, Bundibuja, that we haven't seen before.

24:12Dr. Scott Gottlieb:It's been isolated in two prior outbreaks. They were both very small. The last, I think, in 2007. So they weren't looking for this particular strain. So when cases started to surface, they weren't testing for it. And it took a while. It was a couple of months before anybody realized. Right. So it looks like the earliest cases may have been in March. And so this has been spreading for a very long time before it was ultimately detected. And they started to take actions to try to mitigate further spread. It looks like there's multiple chains of transmission now that we haven't fully isolated. And so this is an outbreak that's out of control in West Africa.

24:42Dr. Scott Gottlieb:It's going to take them a long time to try to get control of this, unfortunately. And the risk beyond that, it's spreading to other countries as well. We've already seen some planes that have been turned around, borders that have been closed as a result of this. Right. And we've seen travel restrictions imposed here in the United States as well. I think the risk to the United States is exceedingly low. I think there could be isolated cases from imported cases. There were people traveling into this country before these restrictions were put in place. We know the incubation period is about 21 days.

25:09Dr. Scott Gottlieb:So it's possible that there'll be cases here. I think there could be some isolated situations where you see a small chain of transmission. Again, I think that's low odds, but we need to be prepared for it. The real risk is to West Africa, where this virus is out of control right now. And if they can't get control of this epidemic in West Africa, that it could spread to other populated regions of the world that don't have good public health infrastructure like India or South Africa. that would be a public health disaster because then it would become exceedingly hard to get control of this. That's, I think, the biggest risk right now, that it continues to spread in West Africa and then jumps to other markets that don't have the kind of public health infrastructure that we do.

25:44Dr. Scott Gottlieb:There's a lot of criticism about funding from USAID that was cut beforehand. Is that part of the problem here? Is there anything we can do with this? Yeah, I think it's very hard to draw that conclusion right now that the funding cuts contributed to this. I think, you know, we'll see how this goes forward. I know the U.S. government, I spoke to people within the administration just last night. There's a lot of effort underway across the State Department, BARDA, CDC, HHS, sort of an all-of-government approach that funding, putting tens of millions of dollars into the region right now. So I think the administration is focused on it.

26:12Dr. Scott Gottlieb:I think, you know, we can look back a year from now and see what impact, if any, the funding cuts had. But it's too early to draw that conclusion. There is a new acting commissioner at the FDA, Kyle Diamantis. And there's a stat story out today. I'm quoting it. Yeah, that takes a look at him. And overall, he's getting pretty high grades from a lot of different people, yourself included, about what's going on. And I think the key that at least Steph points out is that he's earned the trust of key career staff. He came in, he was relative unknown, a lawyer who'd been representing food and beverage and tobacco industry clients.

26:46Dr. Scott Gottlieb:But he's won over some of the staff there by listening and kind of following what recommendations have been made by the scientists. Yeah, look, he has, I will tell you, I speak to staff at the FDA. He has a very good reputation inside the agency as someone who's worked through the process, works with professional staff to try to advance policy. He goes through notice and comment, rulemaking, guidance. He does everything a good regulator should do and a good leader of that agency should do. And I think he's well regarded internally. I do think that there is this view that a food and drug lawyer can't run the FDA.

27:14Dr. Scott Gottlieb:I disagree with that. You know, there's a view that has to be a physician, but that's sort of of an outdated view that I think stems from when George Bush tried to put forward a lawyer to run the agency, and ultimately the Senate rejected it based on those grounds. But that was more of a political fight that was going on between certain senators in the administration at the time. I think an attorney can run the FDA, and I think he certainly has a good reputation in the organization as someone who's been very effective. Andrew, you want to talk to you? You know, I always want to talk to you because I'm fascinated by it all.

27:44Dr. Scott Gottlieb:And the new report last week that got me even more intrigued by all of this is this potential that it is reducing the risk of cancer. What do you think of that? Yeah, look, these were multiple observational studies right now that showed this effect. And so I think it's very interesting. They obviously need to be replicated in prospective studies right now, which are underway. There's been situations before we've had drugs that affect metabolic health, like metformin, that showed an anti-tumor effect in observational studies. It didn't pan out in prospective studies. That said, I think there could be something real here.

28:17Dr. Scott Gottlieb:The drug is impacting overall metabolic well-being, so that could impact glycemic control. On top of the idea that if you're losing weight, you would probably naturally be less prone to cancer. There's something else. Well, there's anti-inflammatory properties here. We know there's GLP-1 receptors on certain cancers, so there could be a direct effect. But I think most people who are speculating there may be a real effect here are speculating around the anti-inflammatory effects and the overall improvement in metabolic health. Again, we don't know. The observational studies are very intriguing.

28:47Dr. Scott Gottlieb:They need to be replicated in prospective trials. I wouldn't take the drug for that, but this could be something we ultimately discover. What are the, just back to Ebola, what are the possibilities for therapeutics? There's good possibilities. So there's a drug by MAP Biotherapeutics, biopharmaceuticals called Mbp134. That's a monoclonal antibody that looks to be effective preclinically that's going to go into clinical trials. Gilead has a drug, Obeldesivir, that looks like it's effective in preclinical studies. And it just blocks something in the genome. Yeah, they block viral replication. The antibody obviously directly targets the virus.

29:19Dr. Scott Gottlieb:Also, Molopiravir, the drug from Merck that was approved for COVID, looks potentially effective. Remdesivir is being used in the region and showed some preclinical activity. No, you can't use an anti-retroviral drug. No, it doesn't replicate that. Because it doesn't use. Yeah, and there's two vaccine programs that are relatively advanced preclinically. One is built off the platform of the approved Zaire vaccine. Another one by Oxford University and the Serum Institute in India also looks like it could advance. The vaccines are at best six to nine months away. The therapeutics could be available right away.

29:57Dr. Scott Gottlieb:And the other point I'd make is Regeneron's approved antibody that was approved for the Zaire strain of Ebola. It's a three-drug cocktail. It's a monoclonal antibody. One of those monoclonal antibodies in that cocktail looks to be effective against this. And they're actually using it. I think the physician who was hospitalized in Germany or Czechoslovakia received that. But he's doing okay. He's doing okay. But the cytokine storm, are we dealing with sepsis? Yeah, so what it does is it hijacks immune cells. So it hijacks dendritic cells and then causes dysfunction of macrophages. and that ultimately leads to a cytokine storm.

30:27Dr. Scott Gottlieb:And that's a DIC, you know, sort of breakdown of clotting. So with supportive care, you can get these patients through it. The fatality rate with this particular strain is lower than with the CYS strain. What do you call a strain? What strain you called it? I want to be able to use that term. Bunabouji? Bunabouji. Bundibouji. Okay. I just want to sound like I know what I'm talking about. So I'm worried about the bunabouji. I had to circle it because I've never heard of it. Bundy Bujo. I'll give you the phonetic spelling. I rehearsed it. What was the other strain? The Zaire strain. That's the one from 2014.

31:02Dr. Scott Gottlieb:Oh, the Zaire versus Bundy. That infected 28 ,000 people back then. Jesus. What's with the constant pandemic worries since, I guess we've always had. We've always had. I think there's more focus on it now coming out of COVID. Yeah. Everyone's worried this is going to be the next COVID. Oh, yeah. I guess it can happen. We've always had these epidemics, unfortunately. Dr. Gottlieb, thank you. You're our own AI chatbot when it comes to all things health. We appreciate it. But you're not evil. No. As far as we know. Because I won't be denounced by the Pope. Yeah, exactly. We won't have a gottly encyclical.

31:39Sebastian Mallaby:And that is Squawk Pod for today. Thanks for listening and thanks for starting your short week with us. Squawk Box is hosted by Joe Kernan, Becky Quick, and Andrew Ross Sorkin. Tune in weekday mornings on CNBC at 6 Eastern. Follow Squawk Pod wherever you get your podcasts. Let us know what you think. If you'd be so kind to rate Squawk Pod or write a brief review on Apple Podcasts, that helps other listeners find us. Have a great day. We'll meet you right back here tomorrow.

32:07Dr. Scott Gottlieb:We are clear. Thanks, guys.

32:19Dr. Scott Gottlieb:This episode is brought to you by Schwab Market Update, an original podcast from Charles Schwab. Join host Keith Lansford for this information-packed daily market preview delivered in 10 minutes or less, including projected stock updates, monetary policy decisions, and key results and statistics that may impact your trading. Download the latest episode and subscribe at schwab.com slash marketupdatepodcast or find Schwab Market Update wherever you get your podcasts.

From the publisher

The CDC has expanded U.S. airport screening for the Ebola virus; former FDA Commissioner Dr. Scott Gottlieb discusses risks of outbreak, as well as the potential uses for GLP-1s in cancer treatments. Author of “The Infinite Machine” Sebastian Mallaby discusses Pope Leo XIV’s encyclical on AI, where humanity fits into global innovation, and the risks of unregulated technology. Plus, Uber and Lyft drivers in Massachusetts have formally unionized, Ferrari has released its first fully electric vehicle, and tensions are high in Iran.

 

Sebastian Mallaby - 14:28

Dr. Scott Gottlieb - 24:09

 

In this episode:

Sebastian Mallaby, @scmallaby

Joe Kernen, @JoeSquawk

Becky Quick, @BeckyQuick

Andrew Ross Sorkin, @andrewrsorkin

Katie Kramer, @Kramer_Katie


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