#290: A Secret AI Stock to Buy Right Now?

11 Dec 2025 · 55 min · 17 chapters

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In short

The episode mixes two investing themes: (1) Netflix’s proposed acquisition of Warner Bros. Discovery and (2) “non-invasive” cancer diagnostics (liquid biopsies + AI), plus a short “Following Profit” stock pick.

Guests/backgrounds

Mike (co-host) and Emmett (co-host). They discuss markets and healthcare investing; Emmett is a Horizon subscriber/stock-picker who runs Horizon’s portfolio pitches. No other guests are named.

Key claims

  • Netflix won a bidding war for Warner Bros. Discovery: $27.75/share, ~$82.7B enterprise value (including ~$10.7B Warner debt), with a ~$5B breakup fee.
  • Paramount/Skydance’s hostile bid values Discovery Global lower ($1/share) because Discovery would be spun off; Netflix values it higher ($3/share).
  • Cancer diagnostics: liquid biopsies (ctDNA) can detect cancer, mutations, treatment response, and relapse months before scans; multi-cancer early detection uses DNA methylation to infer cancer presence and likely organ.
  • AI improves radiology/pathology by spotting subtle patterns in CT/MRI/mammograms/PET and tissue slides.

Notable examples/stocks

  • Cancer diagnostics companies: Guardant Health (liquid biopsies; “Garden 360,” “Shield,” “Reveal”), Exact Sciences (Cologuard; Grail multi-cancer tests), Grail, Natera (prenatal/transplant rejection/genetic testing; also liquid biopsy/early detection).
  • Garden Health targets: cash-flow break-even around Q4 2027; 2028 revenue target $2.2B; Shield expanding with ~75% sensitivity and ~99% specificity; multimodal expansion beyond oncology.
  • Following Profit pick: Dicom Industries (telecom/fiber/cable infrastructure; Q3 revenue +40% YoY; earnings +35%; ~$8.2B backlog).

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

Tap a time to open that second in VO

Revenue Growth Projections

0:00 to 0:25

Discussion on increased revenue targets and growth drivers.

“They've increased their 2028 revenue target to$2.2 billion, which would equate to 34 % annual growth.”

Netflix's Bidding War

0:45 to 3:17

In-depth analysis of Netflix's recent acquisition bid and its implications.

“Comcast we can forget about, I think, for the moment.”

Corporate Strategy Discussion

3:17 to 4:25

Hosts discuss Netflix's strategy and potential risks of the acquisition.

“comes to premiumization because Netflix has had this thing where their ad supported models and their cheaper versions have become really, really popular.”

David Ellison's Hostile Bid

4:25 to 5:21

Discussion on David Ellison's bid and its competitive implications.

“An acquisition of this size for Netflix is unheard of.”

Regulatory Perspectives

5:21 to 7:14

Exploration of regulatory aspects and political influences on the bid.

“Now, here we get into the whole succession part of it.”

Shareholder Dynamics

7:14 to 11:58

Analysis of shareholder reactions and the impact on Netflix's strategy.

“his quote is saying allow allowing the number one streaming service to combine with the number where three streaming service is anti-competitive.”

Introduction to Cancer Diagnostics

16:10 to 17:40

Discussion about advancements in the cancer diagnostics industry.

“an industry that's been on absolute fire so far in 2025.”

The Rise of Liquid Biopsies

17:41 to 21:37

Explaining the significance of liquid biopsies in cancer detection.

“Okay, now let's start with the biggest change of all.”

Multi-Cancer Detection Tests

21:38 to 23:46

Exploring the potential of multi-cancer early detection tests.

“Imagine going to your doctor for an annual checkup and being screened for over 50 different cancers all at once with a single blood draw, no mammogram or colonoscopy, no symptoms required.”

Commercialization and Ethics in Cancer Diagnostics

23:47 to 27:58

Debate on the commercialization of cancer diagnostics and its implications.

“You want to find lethal cancers while they're still curable, aka not lethal.”
Show all 17 chapters

Understanding Orphan Drug Status and AI's Role in Healthcare

28:00 to 31:30

Learn about orphan drug status and how AI is transforming cancer diagnostics.

“But the reason all of these things are in place, the orphan drug status, is because the companies need to get the reward at the end of the day in order to go out and do what they're doing.”

The Rise of Non-Invasive Diagnostics in Cancer Detection

31:30 to 35:10

Explore the mini industry of non-invasive diagnostics and key players.

Deep Dive into Garden Health's Innovations

35:10 to 42:01

Discover Garden Health's advancements in liquid biopsies and cancer monitoring.

“And we're probably only aware of it because of your garden health holding, but it really has taken off in 2025.”

Insights from Garden's Investor Day Presentation

42:01 to 45:03

Learn about Garden's advancements, profitability timeline, and revenue growth.

“So their path to profitability has been accelerated by a full year.”

The Future of Cancer Treatment and Personal Experience

45:03 to 49:44

Explore the personal impact of cancer and the potential of Garden's technology.

“The share price is 100 bucks and change.”

Transitioning to Following Profit Segment

49:44 to 50:10

Introduction to the Following Profit segment, discussing stock recommendations.

“this promised land where we can live the full life we deserve.”

Spotlight on Dicom Industries

50:10 to 53:51

Discover Dicom Industries' role in AI infrastructure and market trends.

“Mike, let me do my intro for Following Profit.”
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Transcript

Automatic transcript. May contain errors.

0:00Emmet:They've increased their 2028 revenue target to$2.2 billion, which would equate to 34 % annual growth. The drivers for that growth is breakthroughs with their smart platform technology, which, as I said, now predicts how patients will respond to cancer therapy.

0:24Emmet, how are we getting on? Good to see you, Mike. How are you this week? i'm good i'm good i feel like i'm in following a succession episode with this uh netflix crack it's it's really i'm pretty sure this was a storyline in the last season of succession am

0:40Emmet:i wrong i can't remember it fully no you're on the money this is the roy family played by oh what's his name again brian something but the brian cox brian cox brian cox is the kind of walt disney character overseeing this giant multimedia empire and of course there's a border in battle and you're absolutely right so what's the latest with netflix because i gave a piece on it was it last week two weeks ago no and in fairness two weeks ago we kind of didn't i didn't foresee this playing out as it did um but it is it's fascinating because it has all the elements to it it's pure corporate boardroom it's got the nepo babies it's got tech coming into legacy media and all the rest so i'm gonna all right let me get through it first um so basically what happened was Netflix was in a bidding war alongside Paramount Skydance, which is run by David Ellison, son of Larry Ellison, founder of Oracle, and then Comcast.

1:36Comcast we can forget about, I think, for the moment. But Netflix's bid was accepted on Friday. It was a cash and stock transaction valued at$27.75 a share with a total enterprise value of$82.7 billion, which includes assuming$10.7 billion of Warner Brothers debt. So that is kind of where we're standing. Netflix essentially won the bidding war. Now, what's important here as well is Netflix is also subject to a$5 billion breakup fee if the acquisition does not go ahead, which might come into play. So let's talk Netflix first, and then we'll move on to Paramount.

2:12Emmet:But by the way, Mike, just one small caveat. I think it depends on who does the breaking up. So if Netflix breaks it off with Warner Brothers, they owe them what was at$5.9 billion. Yeah. Yeah. And it's about half that if it's broken up in the opposite direction, which I think is the greatest threat at this moment. Absolutely. But then again, if Warner Brothers goes off with bags more money, you know, that could be a rounding error. Yes, exactly. We're going to start with the necklace bit and then we'll get into the kind of corporate intrigue bit at the end. And so, yeah, where do we go? Netflix, it's huge, huge news for kind of media, film, streaming, Hollywood, pretty much anything that's watched on something bigger than a phone.

2:55you know this is really really really impactful so from a just pure content perspective you know integrating media from warland brothers and hbo into netflix platform it's going to go a long long way to establishing netflix as beyond it probably is a must-have now already you know and that that will just take to the next level of just an absolute must-have for global households everywhere around the world and it also brings in a huge amount of opportunity and optionality when it comes to premiumization because Netflix has had this thing where their ad supported models and their cheaper versions have become really, really popular.

3:28And now if you're adding in HBO, if you're adding in like Warner Brothers, the studio, just the amount of IP there, maybe the company has the option, okay, what do we do if we keep them as separate services or, you know, the upper upper tier, the gold platinum version of the subscription, you know what I mean? So I think it is a really interesting thing and then on top of that and the most important thing here beyond the content it just takes a potential big name competitor out of the running paramount or i won't say comcast if comcast did win paramount did win the bid either company could have a potential you know you could have the potential and content to create a very strong alternative to netflix because netflix is absolutely dominant in the streaming world so in winning this bid they have kind of have cut off what could be their encroaching number two, say, in this industry.

4:21So as a business decision, it makes an awful lot of sense. Now, there are some concerns. An acquisition of this size for Netflix is unheard of. They've always preferred to build rather than buy. And we've seen a history of these major media conglomerates, major media mergers, say that three times fast, not doing well. like disney's purchase purchase a fox comcast purchases sky there's plenty of pitfalls here this differs a bit in that netflix is not buying any legacy media channels it doesn't have to manage that it's a content play and we'll put it right at the top of the hollywood food chain like undoubtedly um and it doesn't have to do like there is a small shift in strategy when it comes to theatrical releases but it won't take any major overhaul for netflix to do this so that's where i I see it in terms, in comparing to those two mergers in particular, I think it compares favorably.

5:16I don't think it has the same potential pitfalls of Disney and Fox, of Comcast and Sky. Now, here we get into the whole succession part of it. So basically, David Ellison, the children of Roy, in this instance, the Nepo babies, they've come in here from the top rope, basically, and they put out a hostile bid. So they've gone directly to the shareholders of Warner Brothers with their offer, which is$108.4 billion for the whole shebang. So that includes Discovery Global, which is the cable TV channels like CNN and TNT, which is important because in David Allison, Paramount Skylines' bid, they value that as$1 a share.

6:02So of the$30 a share they're offering, they value that as low as$1 a share compared to Netflix's offer, which has to take into account that that Discovery Global is going to be spun off as its own public company. In that bid, it offers it at$3 a share. So this is where it kind of becomes contentious. And this is where, say, if you're a Warner Brothers shareholder, you'll be looking at that and be like, oh, well, maybe there is a lot more money on the table that we're turning down. Now, more importantly, I think, to this whole thing is that from a regulatory perspective, this couldn't be more cozy with the trump administration we've mentioned larry ellison whose father is trump confidant big donor very involved um he's also got the backing of the saudi abu dhabi and qatari sovereign wealth funds and there's a little kicker as well so jared kushner trump's son-in-law is also involved with the financing of this deal so we're looking at okay did netflix offer a better deal maybe maybe not but david ellison is putting out there that we are way way way more likely to get approved regulatory regulatorily so he said and then there's some there's some credence this as well his quote is saying allow allowing the number one streaming service to combine with the number where three streaming service is anti-competitive.

7:26Now that's obviously a wolf whistle to shareholders. We've got the administration behind us here with this, but there is grounds there. So I don't know what's going to happen next. I imagine we're recording this late Tuesday. If this episode is coming out on Thursday, I'm sure there's going to be blockbuster news on Wednesday that could make all this obsolete. But if it doesn't, it leaves it in a really interesting position. I don't think that Netflix and Warner Brothers were going to leave that, you know, handshake, leave that agreement without considering this possibility. The fact that it is Paramount's guidance's bid that was rejected, you know, it's not an increased offer.

8:08I think that gives a credence as well. But it is interesting to see that David Ellison is kind of putting his finger on the scales, being like, look, you know, who's in the White House? Who's going to suffer if, you know, Netflix doesn't get this deal through? Who do you think has had a better chance of getting this deal through? So it's up in the air. It is interesting. Yeah. What are your thoughts as a Netflix shareholder here?

8:30Emmet:I was interested to see last night that the management team and Netflix said that, oh, we entirely expected this to happen and we're entirely confident we're going to win this particular bid. but it wasn't supported at least in the piece I read by a whole lot of data to understand why they expected it and why they indeed believed they're going to win especially when you're looking at that relationship I suppose is the softest word we can use there's an undeniable relationship between the financing of the deal from Ellison and the deal on the table Par from the fact that Alison and co have offered a sizable amount of cash more than Netflix, it is, as you said, power charged by Kushner.

9:18Emmet:So and then when you consider a relationship, it seems, I don't want to use any negative word, but it's all very much feels like it's in the bag. Do you know what I mean? So how do I feel as a shareholder? I have so much faith in the Netflix management team. Whenever I've doubted them, I've been proven wrong, thankfully. They're very strategic and perhaps they did see this coming and perhaps it's all part of a master plan. It was funny. I sent out a tweet yesterday saying, well, the share price fell when it was Netflix share price fell. I saw this. damned if you do damned if you don't yeah so the netflix share price fell after they were announced as the the winning bidder yeah for wonder brothers discovery then when uh donald trump said i don't think this is going to happen or it's going to get past the antitrust uh assessment uh the share price fell so like and then as i said on twitter pick aside people are we happy or are we unhappy When the Paramount deal came through, Paramount stock went up, Warner Brothers stock went up, Netflix stock went down again.

10:34Emmet:It is just unbelievable. So there you go. We've got a buying opportunity. Yeah. Yeah, it is interesting. It's on a bit of a knife edge. I don't think this public, this hostile bit towards shareholders should change anything, but they are the ones that make the decision. That's what it comes down to. And I think David Zaslav, who was the head of Warner Brothers, he really must have had his ducks in a row when he decided on Netflix. Because what they're saying is that they came out and they expected this. And so he has his board on site. He has enough shareholders on site, I think, to get this over the line.

11:10Or he wouldn't have announced it because it comes down to how much of a deal he can get for his shareholders. Now, some of it is down to, you know, their valuation versus our valuation when it comes to Discovery Global and CNN and TNT and all the cabled news channels and all the rest. So, yeah, it is up in the air. It kind of, if you look at the political motivations behind it, can get a bit murky as well, because, you know, CNN is very much a left leaning news channel, that big critic of Trump throughout its history, you know. what happens when Trump buddies take over that channel. And so that's beyond kind of what we're talking about here on a stock show.

11:52But it is interesting. And I'm sure loads is going to happen. This is the last we talk about it.

11:57Emmet:Yeah, you're right. I mean, the story is going to change, as you said, immeasurably in the next 48 hours. And this is going to be a stale podcast before it hits the first airways. But they did say, the Warner Brothers Discovery Management team in the last couple of weeks did say that it isn't just the check size that matters it's also the legacy so are they setting this business up to ultimately grow into something bigger or at least the brand and its assets now what price is that i mean honestly is is saying that worth turning your nose up at an additional 20 billion or whatever and i'm sure most shareholders would say no if they are being forced out but i wonder i'm just gonna there's a distinction to be made there and this is what i'm saying about the discovery global valuation is that netflix is only buying the studio and hbo it's not do you know what i mean that's where the extra 25 billion is now i don't think anyone is valuing discovery global that spin-off at 25 billion but it is important to make the distinction there because it's easy for the headlines when i saw the headline i was kind of like oh wow because they are buying more than netflix is buying so they obviously have the bigger number i think that's important as well yeah that's true no it's a very valid point yeah well we will see um funny at a hunch level if you park all the uh financial considerations and as a shareholder in netflix i'd love to see them win the deal because that that uh library of theirs is going to go from impressive to almost everything like it is truly something to behold when you look and read through the titles that uh warner brothers discovery hbo actually owns yeah there's no doubt you've interacted and love a lot of their media yeah my only concern and this goes beyond stock this is just as a person who likes going to the cinema i i would have maybe some doubts over their long-term plans of theatrical releases but that's that's a completely another kind of another conversation for another podcast but uh we're going to move on because we've got a lot to cover this episode you want to talk horizon really quickly.

14:05Yeah, and I'd like to remind our listeners, just as the sun is setting on 2025,

14:09Emmet:it's also setting on a ridiculous special offer for Horizon, the service that I run, which has now been re-rated to$3 ,000 a year, but can be subscribed to for a tiny fraction of that amount for a few more days. And why would you care, dear listeners? Well, in the year ahead, I'm going to pitch 12 stocks in a horizon one a month and keep buying into a handful of companies from all the pitches i've made that i believe have the greatest chance of hyper growth when a massive tailwind catches their sales uh one of which i'll be speaking about in this podcast i should add in a few moments i have 26 stocks in the horizon portfolio and some are there mike because uh i I have gained unique insights, as you know.

14:57Emmet:For example, an unheard of, battered up Canadian company I bought a couple of weeks ago. Actually, last week, it wasn't a couple of weeks ago, where I spoke with somebody very familiar with the business. Other companies, such as another one I bought in the same buy alert a few days ago, has many of the attributes I look for in companies that have gone on to grow 100 fold. and that stock I'm mentioning is the most purchased company in Horizons and my personal history. So I bought two stocks last week and they were bought for entirely different reasons. So if you email my colleague, our colleague Frank, before the 22nd of December, he'll send you a link to buy it and lock it in for that massively discounted price, which is a tiny fraction of where we are now, where we're going to bring it.

15:51Emmet:Plus, you'll get my three favorite Nexus stocks from Nexus 1, 2, and 3, which is something I'm working on now. So for the final enrollment on this price point, email frank at mywallstreet.com. That's frank at M-Y-W-A-L-L-S-T dot com. Okay, we're moving on to a very interesting industry, an industry that's been on absolute fire so far in 2025. So it is, I'm not sure really the exact terminology to give this because there is an awful lot that say cancer diagnostics falls under. This is like kind of early screening, early detection, non-invasive cancer diagnostics. Is that fair? It's a bit of a mouthful.

16:34Emmet:Yeah, I think so. Yeah, I think there's an awful lot of satellites in the orbit around cancer, but I think what you've just said is spot on. Yeah. So there are a few companies. so do you want to give us a bit of a backstory about kind of the industry and what it does exactly oh I definitely do I think that's through I'll through I'll run through the names and kind of the performance so far good and then I'll talk about the stock that I have bought in Horizon that has done quite well and I'll explain some more about it and before I do because I can't find a natural segue Mike we had an important conversation last week and a long-time listener and friend of my Wall Street and subscriber Matt Jones told me that the word fluke is indeed used in America but it's generally in relation to an event like that shot was a fluke but the Irish expression of calling somebody a jammy fluke appears to be uniquely Irish so that settles that I just wanted to put that down on verbal record so it stands against the annals of all the other stuff we said just as important if not more so important someone now let me move on so let's just talk about the industry of cancer which i don't like saying or using those words because well i think listeners know the intent of what i'm trying to say so for most of modern medical history cancer diagnosis has had a very specific path that all oncologists have followed and a lump is found a scan is ordered a biopsy is taken and and what i think can be described as a unquestionably very difficult journey begins and something that's invasive and uncertain um i'm sure painful and sickening and sadly often too late um but thankfully cancer diagnostics is moving very rapidly from spotting a lump on a scan to this really rich and continuous molecular picture of what's happening in your body and and it's from just one thing blood and as with most things it's also getting a power up with ai ai acting as an extra set of i suppose superhuman eyes you might say yeah so yeah so we thought you to analyze has just you know grown exponentially in a very short space of time no question or doubt about it so we thought we'd give our commentary but but please folks do not treat anything that we're about to say as a reliable medical insight we're going to do our best but if you have anything of a concern get to a doctor don't bury your head in the sand move into 2026 with a plan in place so i want to just preface everything we're going to say to do not, I mean, be so foolish as to substitute anything we're about to say for a plan of action.

19:29Emmet:Okay, now let's start with the biggest change of all. The biggest change in this world is the rise of liquid biopsies. And instead of cutting into a tumor, doctors can now detect tiny fragments of cancer DNA that spill into the bloodstream. And And this thing is called circulating tumor DNA or CTDNA. And this is real tumor genetic material that's going around in your blood in a very, very low concentration, I suppose. And with one vial of blood, doctors can now in 2025 detect whether cancer exists in your body. They can identify the exact mutations that are driving that cancer. and they can also assess if treatments are working and in many cases and this is the powerful thing this ct dna that you can get from a vial of blood can spot relapse months before a scan and this has completely changed how recurrence for a start is monitored every surgery or chemotherapy like after surgery i mean say or chemotherapy instead of waiting for a scan which might be like every six months or something um which i can only assume is some kind of daily hell when you're when you know you've got this kind of scan that you're waiting to hear you've got the all clear on doctors can now track whether any microscopic disease remains and uh this is called in the in the medical industry minimal residual disease and if cancer is going to come back blood shows it first or at the very least blood can show it first and often shows it first and the implication of that discovery or that insight alone is absolutely massive for start treatment can now be adjusted to start earlier when the disease burden is at its tiniest and and the disease itself is at its most vulnerable and more most um open to to treatments now if we take that idea one step further in this particular scientific race.

21:42Emmet:Imagine going to your doctor for an annual checkup and being screened for over 50 different cancers all at once with a single blood draw, no mammogram or colonoscopy, no symptoms required. You don't need to have discovered something on your body. You just walk in and as part of your annual or biannual checkup, they just take a little bit of blood and they can have a look. And that's the promise behind multi-cancer early detection tests, which don't just look for mutations. They read the DNA methylation patterns they're known as, which are chemical signals that reveal whether not only if cancer is present, but in which organ it likely came from.

22:30Emmet:So now all of a sudden we've got this chemical messenger or in our blood that allows doctors to see if you've cancer and where did it originate and that truly is um we're starting to zero zero in on a family of diseases i as far as i understand cancer is a kind of a term that catches many many different diseases all with their own unique attributes and complexities and as normal people on the streets we just say cancer when in fact an oncologist will understand the ref refining that that word down implies an awful lot of different things so in real in large real world studies adding one of these tests to find out if you got circulating tumor dna to standard screening has increased the total cancer detection more than seven fold now that's in america amongst those who who have it and many of the cancers found have no routine screening programs at all.

23:35Emmet:Things like pancreatic and bile duct and ovarian cancers in some jurisdictions. So routine screening may not be in place. And that's the holy grail of, I was going to say of medicine, but of cancer. You want to find lethal cancers while they're still curable, aka not lethal. Now, I must say that these tests are not fully integrated international screening programs certainly not here in ireland not yet um they have false positives they have false negatives and uh and they cost a lot and those things are still a consideration so if you were to take the irish government to bring it into ireland they will assess how many false positives false negatives and how much how many euros does at cost but the direction of travel for this technology is unmissable like it's it's such a positive development for humankind uh it's it's bigger than we all know a bit like when um what's a good analogy none of us understood how brilliant smartphones would be until we saw them we knew we'd heard there's this thing coming out from apple or indeed most people haven't like those who haven't driven an electric car haven't really embraced how brilliant they are so if you take it you don't really know about something's brilliance until you see it or experience it and i mean as much as this technology is coming down um the line for all humans you've got to presume it will also be something for our pets as well so it's it's a living creature diagnostics thing and for the first time in history population-wide early cancer detection is technically possible yeah and i know I just wanted to jump in because it feels weird talking about this, like a very sensitive topic to a lot of people who are listening and the commercialization of it.

25:32You know, this feels like it should be should be in the hands of a few companies. But I guess this is how this is how it progresses. And you're talking about the direction, which I think is an important thing. We're still the very early stages of this. This isn't going to be a kind of wide scale adoption, especially not globally, not in Ireland for years and years. But it's the early stages of what is becoming kind of a new form of, I don't want to say treatment, but, you know, a step in the treatment process, we'll say. I think it's very important to just kind of realize that, yes, it's an incredibly sensitive topic.

26:07And I suppose the least important thing about all of this is, you know, making money from these companies. But I think it is.

26:14Emmet:That is correct. That is the least important thing. We want it to succeed if we never make a penny or we lose our shirts. I mean, this is for the benefit of humankind and creature kind, perhaps. Yeah. Like you can look at it as a critique of capitalism in general, that, you know, these companies have to make money for their investors and for everything else for it to come along this line. And maybe that's, you know, a greater view on the world we live in. But it is very encouraging to see kind of stocks like this that are truly trying to make the world a better place. And there aren't, if you're being cynical, there aren't a lot of companies that are out there doing it.

26:53And then the way they do it and stuff, you know, it doesn't have to be great. But just in the fact that there are a couple of public companies out there that if they succeed, cancer will be a smaller issue than it is today. Do you know? And a kind of like if you're putting a mission statement out there for a couple of businesses, a couple of businesses we're talking about. So in that sense, I know it is a sensitive issue and it almost feels a bit icky talking about it as if, you know, like stock goes up. But yeah, yeah. It's kind of the it's the necessary give and take, I guess, of this conversation.

27:28Is that fair?

27:28Emmet:It is. And if a capital prize wasn't on the horizon, companies wouldn't set out to achieve what they're out to achieve. Like it is, as you said, it's icky. It's an uncomfortable truth. But why are there hundreds or thousands of pharma, biopharma companies out there? Because they know if they crack the code and cure something that nobody else has cured, they are going to be vulgar, make a fortune. Like this is, and it is that capitalist pursuit that drives the pursuit, I should say. like if you take many moons ago i learned about this orphan drug status where a company can apply to be the only one to bring to market a cure or treatment for a specific illness and and so it's for it's for illnesses that are very very rare in society um i was invested in one 25 years ago called transchirotic therapies and they were out to cure illnesses that i would hope most people that everyone has never heard of, but they had a government protection bubble around them.

28:36Emmet:But the reason all of these things are in place, the orphan drug status, is because the companies need to get the reward at the end of the day in order to go out and do what they're doing. And that's exactly what we're talking about here. But what, above all else, do you and I, Mike, and all our listeners want? Well, we want someone to succeed, whether or not we ever even hear of them as companies, let alone as investments. And then, as I mentioned, AI has entered the doctor's surgery, as it were. And while blood tests are transforming the molecular side of diagnosis, AI is kind of changing how, literally, how we see cancer.

29:15Emmet:And modern AI is now assisting radiologists in reading things like CT scans, MRI scans, mammograms, PET scans. Like these are things that like an AI system doesn't get tired. It doesn't miss a subtle pattern at 4 a.m. in the morning because it's tired. It can scan tens of thousands of images and learn features that human eye frankly struggles to perceive. So like if you take in breast cancer screening, AI support is now detecting significantly more cancers while keeping false alarms at manageable levels. In lung cancer, it's flagging nodules that might otherwise have been overlooked. In prostate cancer, it's improving the targeting for biopsies.

30:05So I know there's a lot of debate in the wider world about AI.

30:11Emmet:AI, is AI peaking, is AI in a bubble? But when you consider just this avenue of the AI world, it's the earliest days of its deployment, and it's already moving the dial. And the same transformation is happening in pathology and tissue slides that once took pathologists, SARS to look through and evaluate, can now be scanned and diagnose and classify tumor types and grade the aggressiveness or whatever else that doctors look at measured immune response. I'm sure there's a whole big shopping list of things that a well-trained pathologist has to consider when they're predicting patient outcomes. And it's important to say that AI is not about replacing doctors.

30:54It's about giving them ostensibly a second brain.

30:59Emmet:It's like the assistant that never blinks or sleeps or wonders what's for dinner tonight. Do you know what I mean? Yeah, yeah. I think this is when we talk about AI, so much of it is focused around the build out at the minute. And we don't really talk about the industries applying it as much as we should. That's right. This is good evidence of the industries applying it and indicating how fast the results are coming. Yeah. So I thought it'd be worth it. So you're going to break down one stock at a kind of deeper level. but i thought it'd be worth it to just spin through the kind of this mini industry as a whole um yeah and just kind of talk about the year of 2025 because it's been an absolute barn burner yes it has yeah so i i've kind of given this like the the non-invasive diagnostic area i guess uh there are companies in the genomic space that are kind of their own thing so we're just going to look at four companies in the non-invasive space so the first we're going on is uh garden health it's this company you've owned for a while and you know this is this is this this is a spoiler i suppose it's the one you're going to give a deeper insight on so this is a pioneer in liquid biopsies um it offers tests like garden 360 and the shield blood test for early colorectal cancer screening then we have exact sciences uh this is known for non-invasive screening tests like colo guard have you ever heard of the company that you have to um defecate in a box and send to them in the post this is them uh they're there for targeting early detection primarily in colorectal cancer they've been a bunch of other tests as well they have grail uh specializes in multi-cancer early detection mced tests uh it uses meth methylation the u.s in this word right methylation based genomics and ai yeah and it's got a commercially available gallery test um so it finds kind of deadly hard to screen cancers and then the fourth i'm going to throw in here is natira uh nat yeah um so it's not exactly it's not exactly in the pure play early screening bracket it does have liquid biopsies and early detection tests but there's a lot more to the business beyond just oncology it's leader in like non-invasive prenatal testing transplant rejection testing hereditary genetic diseases but i want to throw it in just because it is somewhat in this industry and then also it is stan druckenmiller one of the greatest investors maybe of all time it's his largest hole and it's his largest holding in his investment firm Duquesne Capital so yeah one of the greatest investors alive makes that kind of move it's worth paying attention to so I pitched it for Horizon do you remember that yeah I went on a watch list and then I threw it in the basement yeah well I wish you bought it when you did so year-to-date garden is up 230 % give or take exact science is up about 80 % give or take caveat here being that Abbott Laboratories just agreed to buy it there a couple of weeks ago still we're talking about however grail okay is up about 450 year to date and then natira is up about 50 year today so there's a lot of reasons okay i can live with a 50 percent no yeah it looks it looks bad in comparison to the other three um like obviously it's 50 there's a lot of reasons why these stocks are doing well and they're not all universal but 2025 was seen as somewhat of a validation of the thesis that you know early detection and And liquid biopsies are the next step in cancer screening.

34:26So there's real momentum around a couple of Medicare reimbursements and showing up in financial results. They're all growing like wildfire. There's been a lot of positive clinical data to come out this year in favor of these companies as well. And then we also can't overlook the Abbott acquisition. So I think it's about$21 billion. They've decided to buy Exact Sciences for it. And it kind of makes every other company we're talking about here a potential acquisition target too, because there are pharma giants, diagnostic giants in this industry that buy up exciting companies like this, and they can kind of buy new capabilities.

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35:01You know, if they see a burgeoning industry like early detection for cancer, this is how they could enter it instead of going and build it themselves. So all of that has kind of come to play into what has been just a very small industry. And we're probably only aware of it because of your garden health holding, but it really has taken off in 2025. And I think it's been through a bit of a ringer. I think it was based on a lot of potential. And it still is based on a lot of potential. Do you know what I mean? We're still very early doors here. All four stocks we talked about are not profitable. They're spending a lot of money.

35:32There's a lot of clinical trials still ongoing. The potential is definitely there. And 2025 is probably the first signs of it really coming into fruition. So with that, you're going to break down Garden Health in a bit deeper.

35:48Emmet:I will. So I'll start by saying I think that in the decades ahead, we're going to look back on today's diagnostic methods. And certainly before today, like back in the 1980s and earlier, the way we look at medieval medicine now, which was painfully blunt. And I can just imagine when I hopefully I'm at the rich old age of 85 or 90 ago. I remember when I was 50, the way cancer was diagnosed was ridiculously primitive. um i certainly not only hope so but i think so and i do believe that garden health is one of those companies that's going to go through the days weeks months and decades ahead in a more positive sense and actually help countless millions of individuals get on top of something pretty horrible way sooner than they would have otherwise and as as you rightfully said i i pitched it in horizon ages ago a couple of years ago bought it a couple years ago it fell fell fell and I bought, bought, bought and now it's up, up, up.

36:50Emmet:So I own a tiny, tiny, tiny microscopic fraction of the business. So as I said, four decades diagnosing and tracking cancer meant cutting into tumors and waiting for scans and hoping nothing had changed and the gaps in between appointments. But what Garden did was it kind of flipped that model on its head because instead of relying on the tissue, It built its entire business around these liquid biopsies, which, as I described, is, I guess, reading cancer's genetic and epigenetic fingerprints from a simple blood draw. When you look at Gardent, it kind of reminds you of that movie and that book.

37:32Emmet:What was it? Bad Blood? Oh, Bad Blood. Yeah. Yes. Elizabeth Holmes. John Carreau. Yes, exactly. John Carreau or something wrote it. And Elizabeth Holmes, in real life, it's not a fancy, but created a business that with a simple pinprick on your finger and CVS was promising to diagnose a whole pile of issues. But Gardent has done it. It's not a fanciful technology backed by Henry Kissinger and promoted by somebody who's lost their marbles. It is actually doing it. And its ambition is to follow a patient across the entire cancer journey using blood alone. So from the moment of screening through to diagnosis, through to the selection of treatment, and then into the long term monitoring for recurrence, all on a single testing platform, which is very important because cancer is not even a static thing.

38:27Emmet:like patients and doctors understand it it evolves and it mutates and it's horrible it's a nasty it's a nasty gremlin and it it even adapts it adapts its own yeah what's the right growth into what's happening in other words cancer is kind of to use very very pedestrian language sidestep the treatments that they're being hit with and traditional diagnostics really very often falls behind that reality and garden's blood based test allows doctors to see uh changes pretty much in real time which means they're they're keeping up with the competitor as in the competitor being cancer and one of their flagship products the one you mentioned a minute ago garden 360 is used for this really comprehensive tumor profiling so with again that single blood test doctors identify the genetic driver of the cancer and they match patients to the right therapies and usually that only takes according to garden a couple of days which again when you're a sufferer of this awful thing time is of the essence a minute feels like an error and an error feels like days when you're waiting to hear and if you have a doctor who says to you on monday by thursday i'm going to know what to do with you those words alone begin to calm the patient and this is precision oncology in action and the company is also pushed upstream into minimal residual disease also known as MRD which is one of the fastest growing areas in cancer diagnostics so after surgery or chemotherapy even a handful of remaining cancer cells can eventually lead to relapse this is what I mean is it's a nasty gremlin inside you it is a very um what's the right analogy it's it's a very tactical illness it moves it it adapts with what's happening so gardens has another thing called reveal and has a reveal test and it looks for these microscopic traces of cancer in the blood and months before a tumor would appear on a scan which is i said earlier is what you want and that early warning really changes everything who needs more therapy who can safely avoid it because the therapies are notoriously uh difficult as well and who needs closer surveillance so garden's shield test began with uh colorectal cancer and it's now expanding into multi-cancer detection and it's a very simple well the idea is simple it's not simple technology as you can imagine it's very sophisticated technology but the idea is simply you test people before the symptoms appear and when cancers are just still invisible to well you everyone the patient who might check if they have lumps or bumps unwanted and they haven't appeared yet and they haven't appeared to imaging so shield looks not just at dna mutations but epigenetic signals that reveal the presence of cancer and the likely site of origin.

41:34Emmet:And that's amazing. That's like a crystal ball for a medical professional. And in real world studies, SHIELD has delivered extraordinarily high specificity, meaning that there's very few false positives. There are very low false positives, which is one of the big hurdles in population screening. Imagine being told you have something that you actually don't have the practical and the emotional impact that it would have on you even perhaps undertaking medical treatment that actually wholly wasn't needed like you can just see that the you just don't want uh false positives you want zero false positives but anyway under all of this garden's thing is like what it's when i say thing one of garden's greatest assets is not only its technology and its machines and its breakthrough technology but it's their data and they've if they've got data at a staggering level it's built their world's largest clinical genomic and epigenomic database with over a million patient samples which effectively feed into this ai engine called the infinity ai but a million people like us in ireland i think have a good grasp of what a million is because we live in a country with five million people in it so that's kind of like 20 of everyone in ireland if their cancer uh genetics were on a single platform that's what gardened has and and this infinity ai platform um is the biggest and that system actively discovers new disease signals new response predictors and new applications right across oncology okay mike i read gardens 163 page investor day presentation which happened at the end of september so you don't have to and i'm going to give you three takeaways from that 163 page investor day presentation that go a little bit beyond what i've already said to you here so here's three um are they again beyond everything i've just said which i hope is the most interesting but but here's three things that i jumped out at me first is that they have accelerated their path to profitability and you said a few moments ago that all these wonderful businesses pursuing something so so important still aren't profitable and we want them to be so they thrive and survive and grow and push their technology into places where otherwise it might never have gotten this.

44:18Emmet:So their path to profitability has been accelerated by a full year. So they're targeting cash flow break-even about a year from now. That's Q4, sorry, sorry Emmett, do your sums, a Q4 2027, two years from now. They've increased their 2028 revenue target to$2.2 billion, dollars uh which would uh basically equate to 30 34 annual growth um and this the drivers for that growth is breakthroughs with their smart platform technology uh which as i said now predicts how patients will respond to cancer therapy so that's the first of three things in that uh powerpoint deck that i thought was worth mentioning the second is their shield blood test is not is expanding from colorectal cancer screening to detect multiple cancer types simultaneously with 75 sensitivity and 99 percent specificity what a fact and then the third thing um and that's why i'm not an oncologist folks and the third thing is the multimodal platform is so powerful it's enabling expansion beyond cancer into cardiovascular disease liver disease neurological conditions so the prize at the moment and the focus of their their the beam with is on cancer quote-unquote cancer but we are looking at a business that today in late 2025 let me have a look its market cap is 13 billion so The business is worth 13 billion.

46:04The share price is 100 bucks and change.

46:08Emmet:So it's about$104 for a share. It has a founding CEO, help me look up a surname folks. And it is a business that is on the precipice of being one of the participants in the changing humankind. And when we look at revenue growth, it's just up, up, up, up, up, up, up. every year is a solid jump on what it did last year. And for those who are good at listening to numbers and picturing it, when they finished 2016, they'd done 25 million. The year after, 50 million. The year after, just shy of 100 million. The year after, over 200 million. The year after, which was ended December 2020, nearly 300 million.

46:51Emmet:The year after that, nearly four. And so it continues. So where they finished December 24, 2024, which granted is effectively a year ago, 11 months and change ago, its full year revenue was 740 million. To remind you, just a few years before, it was 25 million. It just went up, up, up to 740 million. And we're going to see how this year comes in. But what I will tell you is their return on equity, which is one of those prized metrics looked for by the investors investors we most admire and ourselves uh is gone into the hyper positive territory so what i would say to you is that uh for those reasons for the reasons i've just explained i am a shareholder in gardened i will remain a shareholder in gardened and putting aside genuinely putting aside all um commercial endeavors i want them to succeed i want to find that in five years from now when you go into boots which is a chain of of chemists across the uk and ireland that you can get a garden test or if you go into your local GP that she or he says here come here throw your arm up there for a minute and look out the window and next thing they can tell us that is going to change all of our outcomes but this is a horrible thing these family of illnesses I remember funnily talk about left field reference but in April 1992 I was a kid I was a kid oh I was in my mid to late teens probably 16 maybe 17 and I went over to Freddie Mercury's memoriam tribute in Wembley Stadium he had died and it was a big gig in Wembley and all the world's greatest bands from The Who to Metallica to Liza Minnelli to everyone played at a gig there that was the best thing ever I camped outside the place the night before and I got in in the first 200 people and stood right beside the stage and got to watch it all and i remember when david bowie came out he said to the audience and the global audience we all know somebody who's died from aids and i remember looking at my friend mark and i'm like i don't know anyone do you and mark was like no and i remember saying to mark we all know somebody who's died from cancer and i still hold that to be true it was one of those moments where while david bowie would have apart from being quite a bit older than me at the time and having lived more life and seen more people and being in the arts end of the world and whatever he said that but it felt wrong to me um i was wrong i'm sure but nonetheless even then i remember saying to mark we've all been touched by cancer and that i believe is still true hopefully not close to your home but it is a nasty horrible thing but we're gonna can we humankind we're gonna conquer cancer folks and we're nearly there and i think garden is on the front foot to bring us to this promised land where we can live the full life we deserve.

49:48That's great. That's a great way of finishing out that section. It's an interesting part of the market, an important part of the market very early on in its journey, but hopefully it does become a much bigger part because I think the benefits down the line from everyone beyond commercial are very important. Where are we going next? We're finishing up with Following Profit.

50:09Emmet:Following Profit. Mike, let me do my intro for Following Profit. I've memorized it. Okay, folks, this is following Profit, where Mike or I spotlight one of Profit's current 10 stocks. It's our Just Tell Me What To Do service. It always holds 10 stocks. It rebalances monthly. And I need to caveat it that we will always tell you a stock that's currently hot and recommended and held by the Profit's 10 stock portfolio. And we talk about it in the knowledge that Profit may just sell it in a couple of weeks. and it only rebalanced there last Friday, wasn't it, Mike? Yeah, last Friday. Last Friday. So we've kind of rich pickings to talk about.

50:50Exactly. And I specifically chose one of the stocks it added last Friday to kind of just keep this a bit more up to date. Although in fairness, if they don't go obsolete, if profit doesn't want it in the portfolio, it sells it straight away. So that's not an issue. It sold three and bought three.

51:06Emmet:Is that correct, Mike? Sold two, bought two. Oh, sold two, bought two. Okay, go on. hit us then with half of of that payload which one of the two so the company i chose is the company uh dicom industries d y c o m nope me neither a lot of the the profit stocks i've never heard of um there's a good reason you never heard of it very boring business so it's a specialty contractor works primarily in like telecommunications infrastructure and utilities industries focuses on fiber optic copper and coaxial cable projects. And you'd be surprised to hear this, I imagine. We're talking about one of these old industrial companies.

51:44It's come to the fore as an under-the-radar AI infrastructure place. Surprise, surprise. So it's benefiting massively over the last couple of years from the Accelerating Data Center and fiber network spending. You can see it in the numbers. So Q3 revenues were up 40 % year over year, alongside about 35 % increase in earnings. It's going to see really robust demand for fiber and data center infrastructure projects. And then it's got an$8.2 billion backlog of orders for a 10 billion something company. A really strong momentum behind the stock, which is why it's popping up on profit. It's up about double year to date and about 350 % in the last five years.

52:25Growth is obviously incredibly dependent on this crazy CapEx cycle we're going through at the minute. it's benefiting from the major telecoms the major hyperscapers just spending like there's no tomorrow that doesn't look like it's slowing down anytime soon but we will see there might become a reckoning i think people are waiting for that kind of reckoning um but at the minute it's all all systems go it's certainly on this gravy train for now alongside all these other 60 year old infrastructure players that have just been the hottest thing on the market right now so put it alongside what we were talking about last week uh western digital and oh last week i i carpenter

53:01Emmet:technologies carpenter technologies western digital all these made screws and rickets and i don't know even what they're called metally things exactly sandisk all these 50 plus year old companies that sanders yeah no no no that's high tech that were making floppy disks and putting wires in the ground are all of a sudden the hottest things in the market and this is nickel based super alloys for sticking on to routers and scooters exactly dicom industries is the latest in a long line of these that we've seen this year so yeah it's it's just part of this ai infrastructure build-up play that we've seen for so long and this just seems to be the the story of 2025's market it's it's picking shovels it's been the year of the picking shovel and dicom is just the latest than that ai picking shovels ai picking shovels for sure not actual picking shovels although we're not going to talk about gold on this podcast but gold is like going nuts as well ah gold had the party of parties this year yeah yeah absolutely but uh we've been talking for an hour i don't think we need a tangent on gold at the minute um limited limited medical utility in gold that's it and then it's there to beautify humans.

54:11Emmet:Absolute waste of energy. Absolutely. Right. I hope no one was listening to you say that at the start of the year. They'd be down to money. Emet, thank you for joining me today and thank you everyone for listening in. If you haven't already, we're going to annoy you with this every time we finish the show. But if you're listening for an hour, you must like us somewhat. So please do give us a review. Subscribe if you're on YouTube, if you're on Spotify, if you're on Apple Podcasts, wherever it is. Little thumbs up goes a long way. So thank you very much for joining and we'll talk to you next week.

From the publisher

Mike and Emmet are back and sharing their latest thoughts on the race to secure Warner Bros. Discovery. Despite a seemingly successful bid from Netflix to the tune of $82.7 billion, Paramount and its backers, David Ellison and Jared Kushner, are attempting a hostile takeover. With regulatory approval necessary for both potential deals, all roads lead through the White House.

Later, Emmet discusses an often-overlooked feature of our AI-powered present: advances in cancer screenings and treatment protocols. Researchers are currently testing AI’s ability to identify tiny biomarkers in blood that could catch cancer much earlier than current scans.

Lucky for our listeners, this tech isn’t restricted to research labs and can already be found on Wall Street. Emmet is a long-time investor in Guardant Health, a biotechnology company focused on liquid biopsy. Its tech helps match patients with effective treatments, detect relapse, and catch certain cancers early. With impressive Return on Invested Capital (ROIC) and revenue growth, it’s a great feel-good stock.

We wrap with another edition of “Follow Prophet.”

Our Horizon portfolio is a boutique service led by our co-founder and lead investor, Emmet Savage. According to 100-bagger expert Chris Mayer, “no one owns more 100-baggers than Emmet” and this week he has a particularly enticing stock.

To find out its name and lock-in an exclusive Horizon discount, email us at frank@mywallst.com.

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00:00 Intro02:46 Netflix's Bid for Warner Bros.16:13 AI Advancements in Cancer Diagnostics28:59 The Role of AI in Modern Medicine32:07 Spotlight on Guardant Health43:26 Guardant Health's Financial Growth and Future50:08 Following Prophet: Spotlight on DICOM Industries


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