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a16z Podcast Episode Notes: Curing the Trust Problem with Mark Cuban
Episode Overview Host: Vijay Pande Guest: Mark Cuban Release Date: Not specified
In this episode of the a16z Podcast, Mark Cuban engages in a discussion about the healthcare market, its inefficiencies, and his initiatives to improve drug accessibility through his company, Cost Plus Drug Company. The conversation touches on broader themes of trust, transparency, and innovation in the healthcare industry.
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Key Themes and Discussions
- The Trust Problem in Healthcare
- Inefficiency in Pricing:
- Patients often have no transparency regarding drug prices, creating a lack of trust.
- Mark highlights that prices can vary dramatically—e.g., a medication priced at $2,000 at a pharmacy might be available for $14-$61 through Cost Plus Drugs.
- Financial Chain Distrust:
- After trusting their doctors, patients often don't trust the rest of the healthcare supply chain due to financial misalignments.
- Market Forces and Inefficiencies
- Understanding Inefficient Markets:
- Mark discusses his early entrepreneurial experiences and how recognizing inefficiencies in markets has been critical to his success.
- He emphasizes that these inefficiencies are prevalent not only in healthcare but across various industries.
- Misalignment of Incentives:
- There is a disconnect between healthcare companies' profitability and patient outcomes, leading to inefficiencies and high costs.
- Cost Plus Drug Company
- Mission:
- Mark founded Cost Plus Drugs to address pricing inefficiencies and restore trust between patients and the pharmaceutical industry.
- Transparency Model:
- The company operates on a cost-plus pricing model, allowing customers to see the actual cost of drugs, the markup, and additional fees.
- This transparency has led to significant savings for patients and has been recognized in studies by institutions like Harvard.
- Challenges in the Healthcare System
- Opaque Pricing:
- The healthcare system is described as overly complex and opaque, making it difficult for patients to understand costs.
- Regulatory Barriers:
- Mark expresses skepticism about the effectiveness of government regulations in changing the healthcare landscape.
- Advocates for policies promoting transparency and simplicity, such as universal contracts between insurers and providers.
- Future Vision for Healthcare
- Community-Based Solutions:
- Mark proposes a need for healthcare to return to a more community-focused model where prices are transparent and services are tailored to local needs.
- Innovations in Drug Pricing:
- Discusses potential collaborations with brand manufacturers to provide fair pricing and access to medications, emphasizing the necessity of transparency in the process.
- Personal Insights and Advice
- Advice for Entrepreneurs:
- Curiosity, the ability to sell, and fostering a collaborative environment are crucial for entrepreneurial success.
- Personal Health Practices:
- Mark shares his health regimen, emphasizing fitness, mindful eating, and the importance of maintaining a healthy lifestyle.
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Key Takeaways
- Transparency Builds Trust:
- Mark Cuban's model for Cost Plus Drugs emphasizes transparency in drug pricing as a means to build trust with patients and disrupt the healthcare market.
- Innovation is Critical:
- Emphasizing the importance of innovative approaches to healthcare, particularly in pricing and accessibility, can alleviate many systemic issues.
- Community Engagement:
- A sustainable and effective healthcare model should engage communities in a transparent manner, aligning the needs of consumers with healthcare offerings.
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Listening Resources
- [Cost Plus Drugs](https://costplusdrugs.com)
- Follow a16z on [Twitter](https://twitter.com/a16z) and [LinkedIn](https://www.linkedin.com/company/a16z).
- Subscribe to the a16z Podcast on [Spotify](https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX?si=3E8B3qT9TyiwAHJ7JnaKbg) and [Apple Podcasts](https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711).
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This episode provides valuable insights into the current state of the healthcare industry, the necessity for transparency, and innovative solutions to longstanding issues. Mark Cuban's approach with Cost Plus Drugs serves as a model for potential disruption in the healthcare landscape.
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Transcript
Automatic transcript. May contain errors.0:00You trust your doctor, hopefully, but after that there is nobody in the supply chain or care chain that financial chain that you trust and nor should you. If you were just to walk in and didn't have insurance or high deductible insurance and you walked into one of the big three retailers, pharmacy retailers, you might pay $2 ,000 a month. Our price is depending on its grant, $14 to $61 a month. It's just insane the discrepancy. In the crazier part, the pharmacist who's ringing it up after having gotten the prescription, they don't know what they're going to be charging you until it appears. There's all these things that are designed only to get revenue from the insurance companies.
0:42That's it. Here at the A16C podcast, we have covered the American health care system a lot recently. And for good reason. If you miss those episodes, we covered how FinTech in particular may be playing its role in healthcare disruption. So go ahead and listen to those two episodes we'll link them in the show notes. But today we have one very familiar founder. You may have heard of him, Mark Cuban, who's also got his eye on the same industry through his company Cost Plus Drugs. This conversation covers a ton of ground, but in particular it touches on this idea this really important concept of inefficient markets.
1:23And inefficient markets don't just exist in healthcare so I think there's a lot of learnings here for founders in other industries. This is also a crossover episode from our sister podcast BioWheets World and I recently got a sneak peek into some of the guests they have coming on and there are some really big names just like Mark Cuban so make sure to go subscribe to BioWheets World where every you get your podcasts. Alright, Olivia, Vijay, Mark, take it away.
1:56Hello and welcome to BioWheets World, a podcast at the intersection of bio, healthcare and tech. I'm Olivia Webb.
2:09Today's episode is with Mark Cuban, founder of multiple businesses, owner of the Dallas as Mavericks, one of the sharks on Shark Tank, and co -founder of the Mark Cuban Cosplus Drug Company. He is joined by Vijay Pandey, founding partner of A16Z Bio and Health. Together, they talk market forces in healthcare, the importance of trust to patients, and Mark's ideas to tackle the Gordian knot that is American healthcare. Let's get started.
2:36Mark, thank you so much for joining us. Thanks for having me, Vijay. A lot of people would really be curious to hear about your arc as a founder and as a businessman. And in particular, I was really struck with the fact that you started early. Like you started business when you were 12. Yeah, like I love to hear your take on that and like what drove you to be thinking about business and startups and entrepreneurs and all behavior and stuff of young age? Necessity. You know, and in our household, if you wanted something, you had to earn it. And you mentioned being 12. I went to one of my dad's poker games.
3:11He had at the house with his buddies, and they were drinking and yucking it up. And I went in there asking him for a new pair of basketball shoes. I was a basketball junkie all the way back then. And he was like, you looked at my feet, he goes, those shoes look like their work. When you have your own job and you can afford it, you can buy your own. I'm like, that I'm 12, how can I get a job? And one of his buddies at the poker table was like, hey, I've got these boxes of garbage bags and you can go sell them throughout the neighborhood. And so I did put them in my little wagon, right? And I would literally walk around and you'd be, Hi, my name is Mark.
3:46Do you use garbage bags? You know, and here's to say no to a 12 year old version of this space. And so I learned to sell, which was the most important feature because once you know how to sell in your confident in talking to people and making an offer and being rejected, then it's just a question of picking up other skills. And then from there, I saw magazines door to door, But then like I was 15, 16 and I was looking at happy to pay for my own college. And so I started buying and selling stamps. I would go to stamp shows and stamps at that time in particular in coins were the least efficient market on the planet.
4:22And so literally I could go, I did this. I would go to one dealer in one part of the show. I picked something up. I think it was with 50 cents. When Overt said, look, based off of this catalog, this is this stamp, which is $50, I'll sell it to for 25 and sold it for $25 and I just kept on ramping that up and ramping that up and that helped me pay for a bunch of stuff and sold it in Indiana. And then when I got to Indiana, it was just every hustle all the way to earning a bar and you know, and so it just all just kept on going. And I think that the underpinning of it was if you can sell, if you can recognize where there's inefficiencies, if you're curious, if you can learn and those were kind of the because I learned that I could know more about this little stamp market as a 16 year old than the people who were doing the selling.
5:12There's so many inefficient markets and we'll get to it with healthcare that once you understand that, the opportunities are everywhere. But along the way too, you've also had to build teams, whether we're talking about the maps, we're talking about companies along the way. I'm curious if you have lessons for current entrepreneurs and training for sort of taking, especially a bunch of really high performing people, but how do you get them to work together? When you have a vision and you have a goal and you can align everybody towards that, it's really not hard to get gifted people to come along, even maybe take less than market wages if you give them equity opportunities.
5:48And I think that's really where I was able to really succeed with a lot of the companies I was in. Every company I've ever started, as opposed to took over, I've given everybody equity. You know my first company micro solutions we sold for six million a million of that went to employees We had 80 employees and so there were a lot of really happy people at the time You know broadcast audio net turned into broadcast comm and when we sold it for stock the Yahoo out of 330 employees 300 became a millionaires at least on paper at the time when we kind of told them to the hedge everything and It just went off from there HD net the same thing when we sold that and so when everybody's a participant that everybody is aligned and you can get people personal goals to align with your vision as an organization, it tends to work.
6:33Now, where things get off the rails sometimes is people, you know, bring on their own agendas. But that's one of the values or the benefits, I think, being in the middle of the country here in Texas. Technology is not the industry of Dallas, Texas. We get a lot of great smart kids and from University of Texas, that's from you and other great schools. and we get employees from TI and other great technology companies, but they're not always looking over your shoulder to the next founder or startup that they're going to create. And that makes it a lot easier to have a culture that's geared towards the success of your organization and everybody's participating in that upside.
7:12Yeah, the cultural part seems like a huge deal. How much do you feel like that comes from what you build versus geography versus how you pick the people? How do you build it? I think geography has a lot to do with it. Just the right guys, the mindset here in Dallas, the night and day different than New York, LA, you know, San Francisco, the Bay Area, just totally different. Whereas when I'd go into the Bay Area and the Valley, it was always, hey, we're the smartest. You know, we're dealing with you, where we've got an edge. And that's just, when you're dealing with that, and I've invested in companies there, but you know, talking to founders there, they have a completely different approach in mind that because their employees have a completely different approach in mindset.
7:53Wherever you are, wherever you're headquartered, wherever your bases are for however many offices, geography will have an impact on your culture. It's just a reality. Yeah, that makes total sense. So one last question on sort of the founder, or what advice would you give to your younger self? Like, what do you wish someone told you? I know there's often not a civil bullet, but I'm sure you've thought about it. I would say, don't screw it up. But you know, the interesting thing is there's two questions there. When you're just getting started, I would tell you that curiosity, willingness and excitement to learn, ability to sell, and ability to be nice.
8:32Those four elements, I think, I wish tell me would have told me to be nicer, because I was always go, go, go, go, go, go, go, go, ready fire aim. Let's go. Let's go faster, faster, right? And sometimes it took my partner Todd telling me, Look, you're scaring some people. You're going awful this, then. They're typically going to go and you can't get mad, or if you have, you know, I would get mad if I thought people didn't use my version of common sense. And so you can't do that, right? Because people are not going to be happy with that. And I think the other thing I would add that I think I did right, I was always geared towards profitability, not geared towards just getting my next rate.
9:11When raising money was a necessity, it was a necessity. But I've always tried to teach entrepreneurs that raising money or borrowing money is not an accomplishment It's an obligation and particularly still right now in this market and so gearing towards profitability I think is a message along with you know being curious learning selling etc What brought you that healthcare like right out here of all the things you know you could be doing I started about five six years ago when the Republicans took the White House having friends that were part of that here in Dallas for better or worse, there was the desire to overturn the D .A .C .A.
9:47And so I was like, okay, that's great. What are you gonna replace it with? You know, we started having these conversations that were just intellectual conversations. What would we do if we were gonna change all this and that got me into it and then about 20 late 2018, I think it was maybe early 2019. I got a cold email from a doctor, Alice Ashmeyancy He was a radiologist by training who was super smart and he was starting a compounding pharmacy in Denver. And the goal was to be able to take generic drugs that were in particular on a shortage list, shockingly enough, there are generics that go on shortage lists, you know, and are hard to come by.
10:22And selling them at a reasonable price, knowing because they're in shortage, that there was demand. And as we started going back and forth and I'm peppering with questions, this was also right around the time and the farmer broke, I thrown in jail or the conversation was loud. And I was like, look, if he can jack up the price of the dare print by 75 % that's an inefficient market. And if he can jack it up by 75 % there must be an opportunity to cut it by some amount as well to be able to sell. And then as we started digging into it more, you look, the tech industry has a ton of acronyms, right?
10:55TCPIP, SPACs, they're... Have you made them? Why in different languages? it is nothing compared to the pharmaceutical industry. The pharmaceutical industry has 50 different acronyms for a price, you know? And so the other thing that came to the forefront very quickly was our competitive edge could be transparency. Just showing people what we're doing would create such a differentiation and it would overcome what I think is the number one missing element in healthcare, which is trust. No, you trust your doctor, hopefully, but after that, there is nobody in the supply chain or care chain, that financial chain that you trust, and nor should you.
11:39And so, because of that, that's really was the genesis of CosplusDrugs .com. And it took us several years to get all the licenses, get all the agreements, get all the software done, and the software was just basic stuff, right? API stuff and website stuff. But it took us a while, and then it took us time to get everybody to believe that we were real. So we weren't just the next company making big claims and that's why I put my name on it. If the only company I put my name on it as Mark Cuban Cosplus Drugs. But once we got started, we launched on January 19th of 2022 with our website. So if you go to CosplusDrugs .com, you can look up to see or if your medication is any of the 1100 plus we carry.
12:17And since then, it's just blown up. It's been insane. Well, what do you think about the concept of market forces in healthcare? It's hard to have market forces when there's no transparency and people don't even know what the price of it is. You know, if you think about the process of getting a prescription, the doctor says you need this medication. And the next question isn't what is a clause with the best way. Next question is what pharmacy do you use? And then you go to the pharmacy and you hope your healthcare insurance covers everything that it needs to cover. If you're a big company, you all probably already know.
12:49If you're a middle -sized company, you may not know if you're a small company or a nonchipinor or individual market in Rolly, you're terrified. You have no idea what's going to cost. In the crazier part is the pharmacist who's ringing it up after having gotten the prescription, they don't know what they're going to be charging you unless it until it appears. And so there's all these inconsistent things in this completely opaque industry. And so it was ripe for disruption. And the business model was very simple. We buy drugs. We sell drugs. And when you go to CosplusDrucks .com, you put in the name of the drug.
13:24One drug that we have a huge discount compared to every bail, is a chemotherapy drug called a matknip. And if you were just to walk in and didn't have insurance or high deductible insurance, and you walked into one of the big three retailers, pharmacy retailers, you might pay $2 ,000 a month. Our price is depending on strength, 14 to $61 a month. It's just insane the discrepancy, but when you go to costplusdrugs .com and you put in a mat number or any of our medications, you see our cost. You know exactly what we pay for it. You see our markup, 15%, you can decide if that's fair or not. You see our pharmacy fee, right now it's $3.
14:03It's probably going to go to $5 here in the summer just because our costs are escalating, pharmacy costs are escalating, and then $5 for shipping. And so you know exactly what you're going to pay and why. And that's accomplished two things. It's built trust because people realize we're not stealing, We're not jacking things up, compare them to other sources, or they can compare them to what they've paid, or their companies have paid. And the other thing is, it's created a benchmark. What we didn't expect that's happening now is there's re - there's like Harvard went and took a bunch of our medications early on and compared them to what Medicare was paying and realized that for just a limited number of generic medications, we could save the taxpayers $3 .6 billion a year.
14:47A couple of urologists at Vanderbilt did the same thing for I think seven -year -rology drugs, and it was $1 .2 billion a year. Our government officials at Medicare, CMS, et cetera, just really never had reference pricing that was legit that they could use. And by providing that, again, in Genders Trust, and opens people's eyes that were the real deal. Originally, it seemed like this was going to be about generics, but you recently signed a deal for two non -generics. What does that look like, and where you keep on going? What's the future look like? Fundamentally, there are a couple problems that pharmaceutical manufacturers have.
15:24And it's easier for generic manufacturers to deal with them because typically, not always, but typically for a generic medication, there's competition. So we could go in there and, you know, even at lower volumes, at least find one of the competitors and have the opportunity to sell it. So the generics were the low -hanging fruit for us to get started. But they also, when you talk to generic manufacturers, they feel demonized as well. Brand manufacturers definitely feel demonized because when anybody talks about the price of medications in this country, oh, it's the pharmaceutical industry. It's the manufacturers that are the bad people that are jacking up the price.
16:01Look at insulin without realizing, well, the retail price of a violence that may have been $300 some dollars, but the net revenue to Lily, and it's clear in their courier on this conference call, as they talk about it, was in the 20s. And so initially by working with generic manufacturers, that kind of proves a concept, allowed us to gain a base of customers and talking to the brand name manufacturers, they hate the system. They absolutely hated their demise. And they don't like the game of having to kiss up to the PBMs, the big three PBMs. And the influence they have on pricing and patient satisfaction, information access, all the above.
16:40And so we talked to Janssen, part of J &J, and we've been working on this for invocana and the most the variations of it for over a year now. And just the contractual side of it is the difficulty. It's not the desire by the brands to work with us. It's just dealing with all the contracts because the big three PBMs don't want this to happen. What's the grandest vision of this? Like do you become a PBM? No. Well, in essence, we could become a PBM, but we'll work with any PBM that doesn't do rebates. So, Imsana and there's other ones that you can see on the Cosplus drugs .com website that we partnered with.
17:16We'll work with anybody that doesn't support rebates or any kind of ancillary cost additions. That's what creates the distortions in pricing. And then you get a misalignment of incentives because when people don't realize there's a lot of talk now about the bad side of PBMs. But what they're not discussing is the fact that the PBMs either own or are owned by big insurance companies. And they also own the big three pharmacy retailers. And so when we looked into it, our basic evaluation was these PBMs have at least 200 of not 250 different subsidiaries. And so what's happening now, they know because as long as they keep the pricing opaque and the supply chains opaque that they can left pocket, right pocket all the revenue.
18:05So if regulation comes across where the PBMs can't do rebates or they have to modify their rebates, reduce their rebates, they'll get it out of a copay aggregator or they'll charge at the retail level and the patients will pay it there or they'll come up with some other type of play that allows them to accrue more revenue because the one thing we haven't heard, despite all this discussion of regulation and the regulations we've seen, You don't hear any of those big three companies talking about declining earnings or revenues. We started our chat by talking about these arbitrage possibilities, you know, that you can go businesses on and in a sense, this is kind of an arbitrage possibility that people are charging things and you can do better.
18:45But like, people's lives are kind of a different thing than buying a car or buying soap or something like that. Because there's no alignments between patient outcomes and healthcare companies profitability. And there's a lot of discussion about accountable care organizations and value -based pricing. They've already failed. And the reason why they've already failed is because the benchmarks they used to create value is relative. It's like there's a thing called MedPAC that sets the baseline prices of Medicare. And the baseline benchmark for that was from 1993. And it's never been, you know, it gets adjusted, but it's never been rethought.
19:20Is that the right way to do it? When you go, you talk about market forces, you know, this is too much information, but But I decided this colonoscopy to get a CT colonoscopy, okay? And so instead of the rotor rotor kind, and so I went to local hospitals and looked at all the priceless which are online. And it's insane. So the biggest insurance companies for a CT colonoscopy and they show all the different deals and everything. Each insurance company got multiple deals with that same hospital when they're all different prices. and the cash price, 25 % of it. Now, if there were market forces at play, the bigger player should have been able to get better pricing.
20:03There shouldn't have been five different prices for each insurance company for the hospital and their network, but there's not an alignment with market forces or for profitability with the patient. It is now. You need to fail. Insurance has failed. And I'm not here to tell you I'm for a single pair. I'm not. What I am here to tell you is that insurance companies as much as they do a lot of talking about better patient outcomes and they do some things that do help, you cannot be the driver of 30 to 40 % of hospital and healthcare costs or a provider to deal with the administration and revenue collection and revenue identification and call it, you know, a market force able industry.
20:51You just can't. Yeah, aligning in senses of profit and patience are well -being makes a ton of sense. A healthcare operating system that reflects the current operations of healthcare is doomed to fail because you're taking a broken model and replicating it and adding efficiencies on the margin. You know, I tried to get involved with the hospital here recently and they went follow through that I saw that they were for sale was small in in North Texas, and all I asked for were the absolute cost and variable costs. I don't want to know about administration, how you code. I don't want to know about, you know, revenue enhancement cycles.
21:27I just want to know what their nut was that they had to hit every month. So that I can figure out a different way to create revenue. They wouldn't do it. They couldn't do it. I tried to pay for a study that asked the foes of major hospitals what the cost accounting they do. None would participate. Yeah, and so you're speaking to like the bigger problem of like misaligned incentives, lack of transparency, but I agree with you about the limits of single payer, but then what we have left, like what's the way forward? If you go to the origins of pharmacies, in the 1950s, pharmacies, bot medications, they sold medications, they gave you advice, right, on what not to mix and match.
22:09And we went right back to that. The origins of hospital health care insurance was they went to the local communities and they went to individuals and they went to businesses and they went to unions and they said, you know, here's our, here's the amount of revenue we need to break even and make a little bit of money. If you all contribute that, we'll provide all the services that we're allowed to provide and maybe we'll even be a dowel to pull in some crypto term. Well, we'll let the community decide what services retain and what services to add in the cost associated with it. That's what's going to need to happen.
22:44Now, think about what happens when you do that. You guys are familiar with healthcare. There's medical coding, right? There's MCR, Medicare, cost reports. There's all these things that are designed only to get revenue from the insurance companies. That's it. Coding isn't about better healthcare, even though you use it. Medicare, cost reports can be used for analysis, et cetera. But the reality is, it's just a cost associated with generating revenue from the insurance companies. And those insurance companies change those contracts every year, they change the networks that you need even more in the registration.
23:17So you've just got to say slice those out completely. You're describing like help gear driven by consumer forces and like where consumers are the customer we're instead of basically the payers being the customer. But it's got to be more of a Netflix model. You know, it's tell us more, what do you mean in my Netflix model? Meaning that you know, whatever Netflix has in their library, you get for what price? Yeah. It doesn't say I can give you every movie anytime, anywhere, every show, but whatever, especially whatever value we can create from a, you know, a content perspective, you get for this price during this period of time.
23:52And it's a silly analogy at some levels, but it's true that if a hospital has X number of doctors for X specialties and they can offer it, and this is what the community feels it needs to support itself, then the community knows, let's just say pick a number out of the year. It's $100 million a year for fixed overhead and estimated variable costs. So we have to generate $100 million this year, $110 million next year, just break even, right? And we'll play to break even. Now all of a sudden you can go to the community, go to the city, state, county, you know, local businesses, local people, and say, okay, how do we create $110 million to support this community?
24:30And once you extract all the other mischegos, right, all the overhead that's associated, that's designed to hide and deflect and everything else, now you can start looking at a market -based model that truly works. And it stays market -based because, well, let me have one thing. It's got to be 100 % transparent. It's got to be a system where your general ledger is open and available 24x7 on a read -only basis to anybody who wants to see it. Think about what happens then. We're already in a world where people are talking about more transparency for salaried and earnings. So maybe some doctors might not feel comfortable with that or nurses or janitors might not feel comfortable with it.
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25:15Okay, don't work here. But if we're going to change healthcare just like we started showing our prices, our costs, that's what it's going to take. You have to extract all the ancillary costs that aren't aligned with better patients or better better patient outcomes or better costing. And the only way to do that is to just extract away payments are done today. Where is the role of innovation? And often in the or not if you're in a sort of cost plus world, I know that's not what you're describing for everything, but like in that type of world, you don't get paid for innovation, you just get paid for doing the services.
25:49Sure you do. So right now like with specialty drugs, it might be $3 .5 million for a hemophilia a drug, right? But the way they price that is knowing that other, the total addressable market of patients, there may be, let's say, 10 ,000 patients, they know that the insurance companies are not aligned with getting those patients healthy. They're aligned with not paying at all, and they're trying to laser and exclude them and push them to their patient programs, right? So if that same hospital or Medicare for that matter could go to the creator of that new specialty medication and say, look, we understand that you've got to make a profit.
26:24And we also understand that there's 10 ,000 potential patients and you're only, you've priced this expecting to only tell it to a thousand of them. That's why it's $3 .5 million. Let's go that Netflix model again and our little hospital here in North Texas who might have a DMA of 100 ,000 people, right, will give you X amount of dollars. And if you take the same approach everywhere else, but for that X amount of dollars, we think it as much of this as you need. Your marginal cost for that therapy might be $1 ,000, $1 ,000, $1 ,000. We'll even pay you your actual marginal cost. Just be transparent with us.
27:00Now for innovation, the risk mitigation side of selling what you've innovated on becomes a lot cleaner and a lot more applicable, right? Because the hard part of the innovation is how do you sell it? And how do you deal with the people who aren't ready to take on the new innovation versus those who are and pricing it to deal with that curve. One interesting trends we're seeing in how drugs are being made is that it used to be that all drugs are kind of discovered and removing closer and closer to world where they're designed where you have platforms that can actually go after a variety of things.
27:35To the extent you have a real platform, you can ask from the beginning not just like, like, oh, what kind of discover? But like, what can I go after? What areas would there be the greatest need? What are the biggest markets? You need good data for that, right? But think about how data is siloed right now. The insured's company now that's gonna pay for it and has all the patient information and an aggregate basis across multiple hospitals and multiple providers doesn't share it with anybody. The one of the reasons cost plus drugs is getting popular with and will be popular with brand manufacturers is because we'll allow them to have a direct relationship with the patient.
28:14The way PBM, the big three PBMs work right now is they charge them for any data. And so you can't learn from it because to do what you've suggested requires no learning from a knowledge base to know what you need and the best application of your innovation and dollars, right? And so there's no centralized source of information. and everybody wants to sell that. And so there's ways to get there, but again, transparency sometimes is the most innovative element because in an industry where it's completely opaque. Yeah. Well, what you're describing sounds almost like Amazon marketplace for drugs or something like that, right?
28:54Yes or no. Early, Amazon 1997, yes. It's a great, Amazon 2023 completely different. Yeah. Yeah, there are enough. Well, I love to switch gears and like, talk a little bit about like policy and regulatory style of the world because so much of this gets entangled in there. You know, maybe it started in blue skies from the beginning. Like what, what are the things that we need to change to sort of get to the US healthcare going to work we all want to go? I mean, I think our collective dream is for it to be the best healthcare in the world. But I don't think we feel like we can't say that today. What are the changes we were talking about of policy, business, or otherwise.
29:34But I have a feeling policy would be a key part of it. Actually, I think it's gonna be hard. Simply because right now politics is so much about perception as opposed to reality. And we wanna have a great headline as opposed to a great result because, you know, not long after the headline is released, people don't track what the results are. And debatably solving problems doesn't like really gain political points, right? Right. And again, putting your hat on of the people who are being regulated, who is more agile, them or the government? Who's going to be able to tie in ways to retain? It's rare if ever that you see in the healthcare industry, people talking about having net reduced revenues for because of regulation.
30:22It may be because of pandemic or such or whatever, but But those people who run the companies that are going to be most impacted, are not afraid of the regulations, then they lobby the hell out of it. And when you talk to our politicians, it's rare and difficult for them to understand it. So what do you do? You look for the things that are simple. An example, again, that will never get past, open GL, complete transparency. If you want a new business with Medicare, the general ledger for your company has to be online 24 -7 for anybody to see. Never gonna happen, but it sure would change the game.
31:01Well, how would that change the game? Like, you wouldn't be able to hide? Well, yeah, you couldn't hide anything, which means, and because it's public, every CEO is gonna be over the gun for every decision they make, which is, you know, and most people aren't gonna understand what they see, but if you were I or any of us who are looking at it, we're gonna be able to go, bam, bam, bam, bam, bam, right, and understand where things are going. But, so that won't help. But then you see, you can look at simpler things. So if you look at the we referenced earlier the contracts between insurers, the payers, and hospitals.
31:29And the fact that there might be five different contracts for a particular item and but more importantly, they change every year. You could say one, you have to use a universal contract that every hospital has to use and every insurance company has to use. So you simplify the administration of it. But you can say that you can only change it every two years and not every year. You can say that you can't change your network for some period of time. Those are the types of things that are low hanging fruit that, you know, again, might save 1 % on the margin. But 1 % in this world is a big number. Oh, it's a huge role.
32:07It's almost a quarter of our GDP, right? So 1 % is enormous. You have some really intriguing plans like your 10 % plan. Maybe you could tell the onset of it more about it and like where is that going like it it was intriguing idea As I mentioned earlier that when the Republicans came in and we're talking about getting rid of the ACA And I asked the question what next so I started talking to people and really Single -payer is tough because it's almost like the ability of kids to always be able to get alone for school When you have the ability to always get alone the universities have no reason to put it to tamp down tuition or cost because you can always borrow and And guess what costs go up like really fast really fast and that's the same problem with single -payer healthcare one The government fundings all the all the providers are going to see it coming and the government's not a great Negotiator and two when you read any of the single -payer proposals for legislation They always put the head of HHS in charge of it.
33:08And that's a political position. And so you can see every four years, it would just be really, really tough. So what I thought was, you know, to paraphrase somebody, I shouldn't paraphrase as a capitalist, but from each, according to his ability to pay, that doesn't sound like capitalism to me. No, I mean, but sometimes capitalism should be compassionate, you know. And I should be able to pay full freight. And somebody who is under 2X, the federal poverty level should pay anything at all. And that was the genesis of the 10 plan. But then who would pay for it? I would pay for all of mine. You would pay for all of yours.
33:42Somebody who's on your two times, the federal poverty level would pay none. And then it would be graduated on a means -tested basis. So if you made 220 % of the federal poverty level, you might pay 2 % of the bill. And then the balance would be paid by the federal government and it would accomplish a couple things from the provider end. And if every hospital bill is paid for, that cuts administration costs and results in less dispayments and all these other things. They're insurance, they're malpractice insurance is paid for. And then the third one was it would be at Medicare rates. So anybody who would use this program would pay at Medicare rates.
34:18And so when you netted it out, it saved like $17 billion a year or something. I forget the exact number. And it would be night, but getting it implemented. I went to DC and talked, it was no chance. But I learned a lot. I learned a lot. Is there any optimism you'd have for like what's going to happen in politics or healthcare? Like, no. Anything? No. No. Are you saying that there's no hope for government? And so therefore we have to do it ourselves or what's the sort of. I was thinking like I was thinking a week ago. So in this past week, I talked to a bunch of people actually in the White House at CMS and CMS Innovation Center, who are very receptive.
34:58And I'm trying to get them on the concept, particularly with medications of just absolute pricing. You know, because I'm talking about pharmacy pricing, there's wholesale acquisition costs, there's wholesale average costs, there's the NADAC, there's this, there's ASP, there's all these other things and that the PBMs used to say, well, if my retail price is way up here, then I give you a 70 % discount, that sure sounds nice, but the problem is, it's an inflated, invented number and it only looks good to people who really haven't looked at absolute dollars because prior to Cosplus Drugs there was no publishing of pricing so they had no way to refer.
35:37I've tried to get them to say let's just work from absolute pricing. Perhaps those are the first real market forces we need to have as foundation. You apply the same thing to hospitals and providers. You have to come out with your actual cost And here's how you have to define how you out how you burden those costs, you know, for very, you know So you burden in your fixed costs according to every service that you offer because one of the things as I was working on the template and the things I did I had somebody on put together comparison between a big Toronto hospital as best we could and a big New York City hospital and Real estate is more expensive in Toronto doctors and nurses get paid the same Band -Aids cost the same Why is it that the top 35 procedures in Toronto, in many cases, were less than our Medicare pricing a couple years ago?
36:25Right? It makes no sense, but then you start to realize Canada pays for malpractice insurance. You know, Canada makes sure that every bill is paid. There's times when you're gonna have to wait, so things have to be scheduled. And so there's not the ability for someone just to come in and overpay to get something. But there was no multi -pricing, what, multi -pricing within a province, right? by an insurance company. And so there's ways to get there, but it comes down to like in Canada, they make a presentation to the province. Here's my cost, here's what I need. There's none of that transparency in the United States of America.
37:00You couldn't go to any hospital that gets money from the government for anything and say, what are your actual costs? Down to each line item. I haven't seen it if it's there. Now, you're right there. So one of the questions that's been fun to ask our guests is what you do for your own health. You know, like I don't know if it's working out, supplements, meditation, like what's important to you? So first of all, I write down everything I eat. You can go to my fitness pal and my username is Mark Cuban. So if you want to see what I eat, you can follow me there. Two, I try to work out, I take this cardio fitness class right now that's kicking my ass, but I've been the best shape I've been in 15 years.
37:42So I do that. I play basketball, I'll relax with my family, but I'm 64 years old now. So I either gotta do it or it's gonna do me. In terms of supplements, I only do the things that I know, I feel impact my body, right? So I've tried this and that and this, but I know I get rest of the late at night. So I take magnesium. I know I'm vegetarian, so I take an iron supplement and eat a lot of total cereal, because it has iron in it. I'll take melatonin if I'm not sleeping well. I don't do the nads and this and that to try to increase the size of my telomeres. I'm still not all of them all that Yeah, fair enough.
38:20Okay, so no one blood no young blood Get him absolutely kidding. Yeah, yeah, so three quick lightning questions And I think I'll take us home. So first off, you know, all the businesses you bought and run what's your favorite? This one. I mean broadcast calm at the time was amazing because we started the streaming industry nobody knew what it was and people dies, which is bug -out every time they could listen to something, they never had access to it too before. But when people walk up to you on the streets, that you know, just start hugging you and crying because now their mom or themselves or their granddad can now afford their medications, that's why this is the only company I've ever put my name on and that's why.
39:03Great. Who would know it's even more? PBMs or NBA officials? NBA officials. At least I know what TBMs are doing, why PBMs do what they do. They're just trying to make as much money. They're all public companies, right? Get that stock price up. MBI officials, I haven't been able to understand it for 23 years. It's cost me a lot of money. Yeah, I can imagine. And last one, this might be a hard one for you, but like, okay, so we're in 2040 and you're looking back, who's had that better career at Luca or Dirk? Oh my goodness. I think Luca has the ability to have a better career because, you know, he can rack up assists, but hopefully they mirror each other, championship or multiple championships in 21 years with the Dallas maverick.
39:47Mark Cuban, thank you so much for joining us. Thanks, BG and I'll just say it again. Please go to costplusdrugs .com, put in the name of the medication you take or somebody you know takes. We don't spend any money on marketing. It's all word of mouth. So please check it out. I know we can save you money.
40:08Thank you for joining BioWheets World. BioWheets World is hosted and produced by me, Olivia Webb, with the help of the Bio and Health team at A16Z, and edited by Phil Hexa. BioWheets World is part of the A16Z podcast network. If you have questions about the episode or want to suggest topics for a future episode, please email BioWheetsWorld at A16Z .com. Last but not least, if you're enjoying BioWheets World, please leave us a rating and review wherever you listen to podcasts. The content here is for informational purposes only, should not be taken as legal, business, tax, or investment advice, or be used to evaluate any investment or security, and is not directed at any investors or potential investors in any A16Z fund.
40:46Please note that A16Z and its affiliates may maintain investments in the company's discussed in this podcast. For more details including a link to our investments, please see A16Z .com slash Discloters.
From the publisher
Today’s episode is with Mark Cuban, founder of multiple businesses, owner of the Dallas Mavericks, one of the sharks on Shark Tank, and cofounder of the Mark Cuban Cost Plus Drug Company. He is joined by Vijay Pande, founding partner of a16z Bio + Health.
Together, they talk market forces in healthcare, the importance of trust to patients, and Mark’s ideas to tackle the Gordian knot that is American healthcare.
Listen to our last two episodes on Healthcare x Fintech:
- When Two Giants Intersect: Healthcare Meets Fintech
- How Fintech is Reshaping Our $4T Healthcare Industry
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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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