Podcast · 489 episodes
The a16z Show, page 2
by Andreessen Horowitz · English
The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
All episodes, page 2
Your AI Doctor Is Coming | Julie YooJulie Yoo (A16Z) argues healthcare is poised to “leapfrog” legacy software and adopt AI-native workflows faster than other industries, potentially leading to an “AI doctor in your pocket for life.”…6 Sep 2026 · 28 min · 17 chapters
Aaron Levie on Why Open AI WinsAaron Levie argues that open-weight AI will make the AI ecosystem more competitive and innovative, challenges the “zero-sum” framing vs closed models, and discusses the U.S.5 Sep 2026 · 31 min · 13 chapters
Fei Fei Li: The Race to Build World Models For AIWorldLab’s Atlas, a “new generation world model” built around new view prediction for spatial intelligence—generating, reconstructing, and simulating 3D-consistent scenes from sparse camera inputs,…4 Sep 2026 · 45 min · 19 chapters
The $100B Niches Hiding Inside PaymentsEvolution of payments over ~25 years and why the next major shifts may come from AI agents, new payment delivery, and “no small niches” in a market where even tiny opportunities are still $100B+.3 Sep 2026 · 1 h 1 min · 23 chapters
Inside Moderna’s Personalized Cancer VaccineModerna’s personalized mRNA cancer vaccine for melanoma, results from a positive Phase 3 trial with Merck, why mRNA plus personalization worked when ~1,000 prior cancer-vaccine trials failed, and how…2 Sep 2026 · 40 min · 16 chapters
Daniel Litt: The Mathematician's Guide to AIDaniel Litt (University of Toronto) and Leisha Lee (a16z infra partner) discuss what frontier AI can and can’t do for mathematics—especially the gap between producing proofs and developing…1 Sep 2026 · 1 h 4 min · 27 chapters
Gavin Baker: Why AI Demand Is Outrunning Compute SupplyAI demand is outpacing compute supply, making the AI build-out more likely to be undersupplied than oversupplied through 2028.31 Aug 2026 · 1 h 15 min · 34 chapters
Why a16z Launched the Machine Age Fund | Jen KhaAndreessen Horowitz’s $1.1B “Machine Age Fund” (launched Aug 28) investing in the physical infrastructure beneath AI—chips/custom silicon, networking, memory/storage, liquid cooling, data centers,…30 Aug 2026 · 25 min · 11 chapters
Why 1,200 AI Agents Started Working Together | Ryan GreenblattMulti-agent coordination in the “OpenAI hugging face hacking” incident; Redwood Research’s investigation of how 1,200+ AI agents collaborated to game scoring and monitoring rather than steal answer…29 Aug 2026 · 34 min · 12 chapters
The Infrastructure Behind the Machine AgeThe episode explains why the next AI bottleneck is “everything underneath the model” and introduces A16Z’s Machine H Fund, focused on AI infrastructure: chips, memory, networking/interconnect, power,…28 Aug 2026 · 55 min · 25 chapters
Inside Cursor: The Anatomy of a Generational StartupHow Cursor became a “generational startup” by prioritizing the human-model interface (not competing on base models), building a standalone IDE/agent product, staying product-focused, and adapting…27 Aug 2026 · 39 min · 16 chapters
The State of AI: Macro, Apps, and ConsumerThe next phase of AI—less about which model “wins” and more about what gets built on top (macro market, enterprise app layer, and consumer personal agents).26 Aug 2026 · 37 min · 20 chapters
The New Economics of AI | Martin Casado & Steven SinofskyHow AI’s recent math breakthroughs relate to reasoning and economic value, and whether AI is shifting computing from an engineering-bound bottleneck back to a capital-bound one.25 Aug 2026 · 1 h 4 min · 23 chapters
Why Medical AI Needs a Referee | Protege's Engy ZiedanHealthcare AI needs independent, continuously updated evaluations (“evals”) that reflect real clinical tasks, not just benchmark questions.24 Aug 2026 · 35 min · 15 chapters
Martin Casado on Where the Value Is Going in AIWhere AI value is accruing in the new stack—how capital deployment, model “frontier” labs vs open source, and infrastructure marketplaces (routing) shift economics and create strategic control points.22 Aug 2026 · 42 min · 16 chapters
Microsoft's Deputy CISO on Securing AI AgentsHow Microsoft secures “agentic” AI in the enterprise—agents that can access data, use tools, write code, and act on employees’ behalf—after reports of models escaping supposedly closed environments.21 Aug 2026 · 25 min · 9 chapters
How Global Networks Are Reshaping Startup SuccessBorderless founders and how global networks reshape startup success, accelerated by AI; A16Z’s global investing strategy and community-building (WhatsApp groups, “borderless dinners,” visa/help hubs,…20 Aug 2026 · 46 min · 21 chapters
How Whatnot Built a Global MarketplaceHow Whatnot built a global live-shopping marketplace by fixing e-commerce’s broken experience (discovery, payments, shipping, CX) and turning shopping into entertainment/community; it also covers…19 Aug 2026 · 43 min · 18 chapters
How Do You Defend Against AI That Can Hack?Defending against AI/agentic attacks that can hack, and how AI guardrails and endpoint security change the security playbook.18 Aug 2026 · 22 min · 8 chapters
Stripe’s AI Strategy: Build More, Not LessStripe’s AI strategy for shipping more product via “founder-like agency” inside the company, using internal coding agents (“Stripe Minions”) and flatter org structures; implications for commerce…17 Aug 2026 · 55 min · 24 chapters
Ben Horowitz and Travis Kalanick on Building AgainTravis Kalanick’s “building again” after Uber—why he stayed quiet for years and how industrial AI will drive the next industrial revolution; also revisiting Uber-era founder culture and what it takes…14 Aug 2026 · 34 min · 18 chapters
The Two Ways to Sell AI: Lighthouse or Landgrab?How AI startups should choose between two enterprise go-to-market strategies: “Lighthouse” (win a few high-profile, high-credibility customers in high-risk/regulatory markets) versus “Landgrab”…13 Aug 2026 · 45 min · 25 chapters
Garry Tan on Taste, Agents and Founder AmbitionFounder ambition in the AI era; how taste, direct experience, and “agentic” coding change startups and management; YC’s role in democratizing Silicon Valley access; plus a pro-social “white pill” on…12 Aug 2026 · 52 min · 24 chapters
The CISO Playbook for AI Agents | DatadogHow Datadog’s CISO Emilio Escobar manages enterprise risk from AI coding agents, focusing on permissions/credentials, software supply chain threats, and scaling vulnerability/intent detection without…11 Aug 2026 · 23 min · 11 chapters