Cell Reprogramming - The Future of Aging Reversal | Dr. Rhonda Patrick EP 920

0:00There are two big things happening at one time that I've never done before. I'm going on a book tour for my new book, Make Money Easy, and I'm doing a podcast tour at the same time. It is going to be big, and I'm going to seven cities in 10 days. Get your friends, get your family, bring everyone you know to these cities. I'm coming to Austin, Texas, New York, Boston. We're going to Nashville. Then we're going to Los Angeles, San Diego, and San Francisco. Make sure to get your tickets right now. Go to lewishouse.com slash tour. Again, bring everyone you know if you're looking to create more financial freedom and abundance in your life and you want to see a massive guest live on the School of Greatness show.

0:45Get your tickets. I can't wait to see you there. Hi, my name is Lewis Howes and welcome to the Daily Motivation Show.

0:59The epigenome resets, completely resets, and there's no sign of aging. It's kind of fascinating, isn't it? It's very fascinating. So how do we reset it within ourselves? That's the question. And so now there have been over the last, I would say, oh gosh, five to seven years, there's been, so, okay, let me take it even a step further back. Okay, back in 2006, Shinya Yamanaka, a Japanese scientist, won the Nobel Prize for discovering four different genes that are very specific type of genes. They're called transcription factors because they can regulate a lot of different genes in our body. He discovered that if he took four of these transcription factors and took any cell from the body, any old cell from an 80-year-old woman, skin cell, and he put these four transcription factor genes on them, on that old 80-year-old cell, he could revert it into an embryonic stem cell with no sign of aging, right?

1:56It's an embryonic stem cell that now can form any cell in the body. It's called induced pluripotent stem cell. So it resets the epigenome completely. The cell loses its identity. It doesn't know it's a skin cell anymore. It's an embryonic stem cell, but it can now form any type of cell, right? And so that is also evidence that resetting the epigenome, at least to the very extreme case, right? All the way to the embryonic stem cell state is a way of reprogramming the cell into a very youthful state. And there's some more lines of evidence. Cloning is another one. So you take a nucleus from like an old cell, put it in a young cytoplasm of an egg and the epigenome is reset and you have a young organism, right?

2:39So there's there's other lines of evidence of this, but in the last five ish years, there's been some research that have been done by a variety of scientists where they've taken those Yamanaka factors, they're called the four transcription factors, and they've given them to mice, older mice. And they don't want to make all the mice cells become stem cells, right? Like they don't want the cell to lose its identity. It's like a blob, right? Almost like a big tumor cell or something. Right. What they want is to reset that epigenome in a way to make it to return it to a more youthful state. And so they've been able to sort of pulse it on.

3:18You just kind of like you got to find the right timing, the right timing. And so they've they've they're they're making progress with this. And there's been some studies that have shown, you know, you kind of it's called partial cellular reprogramming. So they're not doing the full on reprogram, but they're partially doing it. And it does rejuvenate a lot of aspects of aging in these rodents. There's a lot of hurdles to overcome. And I know that this was the answer you were looking for, but I'm super excited about it. It's very interesting. I think that we are very likely going to through, I think there's this process of epigenetic reprogramming.

3:56And Altos Labs, they're doing phenomenal research. They have a lot of the top scientists. Dr. Steve Horvath, Dr. Morgan Levine. I've had both of them on my podcast. They're both really good. I mean, Dr. Steve Horvath is the one who, he's the pioneer of the Horvath clocks, the epigenetic clocks that can identify this biological age, this molecular age that really identifies like how old you are versus your chronological age. But I do think that if they can figure out some of these hurdles, that we might have a tune-up where we go and get rejuvenated. Like what, reverse o 'clock 10 years overnight or something?

4:35Right, exactly, or more. Really? Yeah. Come on, how far away are we from this? I don't, you know, I don't, I could say a couple decades, I could see for sure, like, because things are really growing, things are growing, and then gene engineering, you know, there's a lot of exponential growth in some of this synthetic biology world where they're, you know, doing all this gene engineering. And it's like, they're just really kind of like, it's kind of phenomenal.

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5:56Again, have an amazing day and I'll see you tomorrow with another episode of the Daily Motivation Show.