Big Pharma's Trillion Dollar Deception on Mental Health | Joanna Moncrief

22 Jul 2026 · 1 h 2 min · 22 chapters

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In short

Critiques the “chemical imbalance”/serotonin myth as the explanation for depression and argues antidepressants mainly create temporary emotional changes rather than correcting a proven biological disease. Discusses how marketing, trial design, and social factors contribute to overprescribing; highlights risks like emotional numbing (anhedonia), sexual dysfunction, dependence, and difficult tapering/withdrawal.

Guest

Joanna Moncrief. Research scientist and author of Chemically Imbalanced: The Making and Unmaking of the Serotonin Myth. Conducted a 2022 landmark review finding no consistent evidence that depression is caused by low serotonin. Background includes reading/engaging with psychiatry’s “orthodoxy” and researching antidepressant evidence; also discusses her earlier work/book The Ultra Mind Solution.

Key claims

Serotonin theory originated in the 1960s; declined after NIMH-sponsored research; was revived and marketed by pharma with SSRI rollouts (e.g., Prozac). Antidepressant-placebo differences are small and trials may be unblinded due to side effects. Depression is often context-driven (unemployment, divorce, child abuse, bereavement, loneliness, poverty), and care should be individualized rather than disease-model “one pill fits all.”

Notable examples

1991 Royal College of Psychiatrists campaign market research (public linked depression to social causes, not chemical imbalance); “SMILES” diet trial; ketamine clinics shifting from psychotherapy to repeated injections; Maudsley Deprescribing Guidelines for slow tapering.

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

Tap a time to open that second in VO

The Problem with the Chemical Imbalance Theory

0:00 to 1:06

Learn about the drawbacks of the chemical imbalance theory in mental health.

“What I object to most about telling people that they've got a chemical imbalance is that that is a really depressing message.”

Setting the Stage for Today's Discussion

2:01 to 2:46

Understand the context and perspectives of the upcoming conversation on mental health treatments.

“Before we begin, I'd like to note that today's conversation explores one perspective of an area of medicine that continues to be actively debated.”

Debunking the Serotonin Myth

2:46 to 4:47

Explore Joanna Moncrief's arguments against the serotonin deficiency theory of depression.

“My hope is that these discussions encourage curiosity, critical thinking, and shared decision-making between patients and their clinicians.”

The Role of Pharmaceutical Marketing

4:47 to 9:10

Learn how pharmaceutical companies influenced public perception of depression and treatment.

“We're seeing less effective approaches to it.”

Examining Antidepressants and Their Efficacy

9:10 to 13:56

Dive into the questionable efficacy of antidepressants and the placebo effect.

“And so they came up with this idea to persuade people they've got this chemical imbalance and they need to take the drug to rectify this.”

The Myth of Antidepressants

15:46 to 18:12

Explore the issues surrounding antidepressant usage and its effects.

“Well, it seems even worse than that because here you're promising somebody a drug to correct something that is a myth that doesn't really work and comes with a whole host of problems, which is anhedonia.”

Rethinking Mental Illness

18:13 to 21:00

Discuss the misconceptions of mental health origins and societal impacts.

“So it's very important to come off slowly if anyone's thinking about doing that.”

The Role of Nutrition and Lifestyle

21:01 to 24:20

Understand the impact of diet and lifestyle on mental health.

“emotive beings and we have a whole range of emotions throughout our lifetime and they're often situation dependent.”

Empowerment and Agency in Health

24:21 to 28:00

Learn about the importance of personal agency in maintaining mental health.

“Lowering stress levels is great for depression.”

Understanding Agency in Health

28:00 to 28:37

Learn how agency impacts health and the influence of processed foods.

“And unless you have some understanding of how to have agency and how all these things affect you, the average person has no clue that if they're eating ultra-processed food, it's going to give them depression.”
Show all 22 chapters

Pharmaceutical Complex and Illness

28:37 to 30:25

Explore how pharmaceutical and food industries influence health negatively.

“So how do you help people think about that on an individual level?”

The Psychedelic Revolution in Psychiatry

30:25 to 31:36

Discuss the emerging role of psychedelics in treating mental health issues.

“antidepressants and other psychiatric medications for PTSD, for anxiety, for depression, psilocybin, MDMA.”

Concerns About Long-term Use of Psychedelics

31:36 to 34:23

Examine the risks and ethical considerations of psychedelic therapies.

“And that's how I think we should think about all drugs, rather than as things that target underlying pathological mechanisms.”

Drug-Centered vs. Disease-Centered Models

34:23 to 36:59

Understand the difference between drug-centered and disease-centered approaches in mental health.

“We don't have terribly good data on long-term repeated use of other psychedelics, because they're not so often used in that way.”

Understanding Mental Health: Drug-Centered vs. Disease-Centered

43:14 to 45:53

Learn the misconceptions surrounding mental health medications and their effects.

“So given all that, what's a more honest look at mental health today in terms of an evidence-based model of what mental health care and mental health approach to mental illness could be?”

The Need for a New Approach to Mental Health

45:53 to 48:20

Discover the importance of individualizing mental health treatment beyond the disease model.

“And how do we support people with depression without defaulting to antidepressant medication?”

Addressing Severe Depression and Responsible Deprescribing

48:20 to 50:49

Learn about the complexities of severe depression and how to safely reduce medication.

“It's important to say that there is no evidence that severe depression is caused by any specific biological mechanism either.”

Holistic Approaches to Mental Health Recovery

50:49 to 55:13

Explore holistic strategies for mental health recovery and the role of lifestyle changes.

“think about it and think about how the drugs are affecting them, the pros and cons of those effects.”

Hopeful Perspectives on the Future of Psychiatry

55:13 to 56:00

Reflect on the hopeful developments in psychiatry and mental health treatment.

“And two, I think the psychedelic revolution is also opening up a different perspective of how do these things work.”

The Dangers of the Chemical Imbalance Theory

56:00 to 57:26

Explore the negative implications of the chemical imbalance theory in mental health.

“feeling and to make changes and to feel better.”

The Need for Patient Empowerment and Informed Choices

57:26 to 58:37

Discuss the importance of patients being informed and questioning medical narratives.

“believing expert pronouncements about things which are not always accurate.”

Challenging Medical Orthodoxy and Advancing Science

58:37 to 59:24

Learn about the importance of questioning established medical beliefs to advance understanding.

“I think people need to realize there are areas of debate and discussion within medicine.”
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Transcript

Automatic transcript. May contain errors.

0:00What I object to most about telling people that they've got a chemical imbalance is that that is a really depressing message. That's telling people there's something wrong with your brain, there's nothing you can do about it, you've got to rely on, you know, someone giving you a drug. Just correcting that mistake and informing people that there isn't something wrong with their brains and that they do have the capacity to improve, to recover, to change is actually a positive and a hopeful message.

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2:22Dr. Mark Hyman:The views expressed by my guest are her own and reflect her interpretation of the available evidence. My goal in hosting conversations like this is to explore different perspectives, to examine the science, to encourage thoughtful discussion, not to provide individualized medical advice. So if you're currently taking medication, please don't stop or change your treatment based on this conversation alone. Instead, use this episode as a starting point for an informed conversation with your healthcare team. My hope is that these discussions encourage curiosity, critical thinking, and shared decision-making between patients and their clinicians.

2:53Dr. Mark Hyman:Well, Joanna, it's great to have you on the podcast. Thanks for joining us today. Thanks for inviting me, Mark. Really excited to talk to you. I'm excited to talk to you because I think our intellectual history is very similar. We were just chatting before the podcast and a lot of the seminal books in psychiatry we both read and they were really around challenging the orthodoxy and our way of thinking about mental illness and how we approach it. And I think hopefully this conversation will sort of help us understand some of the challenges we're facing around our framing of mental illness, our understanding of sort of some of the myths out there that are propagated that I think undermine people's public health and mental health.

3:29Dr. Mark Hyman:The title of your book is really, really provocative, Chemically Imbalanced, The Making and Unmaking of the Serotonin Myth, which is going to probably strike people like, wait a minute, I thought depression was about a serotonin deficiency and Prozac was about actually helping fix that. And my joke is that depression is not a Prozac deficiency, right? And so I think your essential argument is really this whole chemical imbalance theory is it doesn't actually hold up when you look at it objectively scientifically. And you're a research scientist and you look at these issues objectively, you look at them dispassionately and you're not sort of ideologically driven.

4:12Dr. Mark Hyman:You're just driven by the science. And I find that very refreshing. and also this is a big problem because when you look at the antidepressants as a class of drugs and depression is probably the most prevalent mental illness it's 20 billion dollars a year globally that's spent on this and your your thesis is essentially that they don't really work and in a few cases in some cases they can be helpful but that maybe it's mostly driven by placebo. I kind of want to dive into this conversation with you because we really are at a crisis. I think we're seeing more and more mental illness. We're seeing less effective approaches to it.

4:51Dr. Mark Hyman:And, you know, we keep trying to apply, you know, like we say, if all you have is a hammer, everything looks like a nail. And we're, you know, we think someone's depressed, everybody needs an SSRI or an antidepressant. But you actually have sort of looked at this broken paradigm very carefully and sort of have unmasked this myth of quote chemical imbalance as a root cause of mental illness and the serotonin myth. And you, you did a 2022 review with landmark review that looked at all the data and you found that there was no, no consistent evidence that depression is caused by low serotonin. Like we now can study this.

5:27Dr. Mark Hyman:There's, there's ways of objectively scientifically measuring this. So So if there's no evidence that this is true, how did this idea get established in our psyche? I did the research because I was aware that the majority of people thought that the link between serotonin and depression was an established fact. And yet I knew that probably the majority of psychiatrists and doctors knew that actually it was a theory and that there was maybe a bit of evidence for it, but probably a bit of contradictory evidence too. And in fact, there'd been people saying that the theory that depression is caused by low serotonin wasn't really supported by evidence for quite a few years.

6:15There was a paper published in 2005 suggesting that. But there was nowhere that you could really point to say, oh, you know, there's an overview of the evidence and it shows that really it doesn't stack up. So that's why we, you know, that's why we did that review of the research on serotonin and depression that you mentioned that was published in 2022. So where does this idea come from? Its origins are in the 1960s. It was first proposed by psychiatrists and people doing research on drugs that they were proposing might be antidepressants back then, that depression might be caused by a lack of noradrenaline or serotonin.

7:05Serotonin and noradrenaline are both chemicals that are found in the brain and transmit nervous impulses between nerve cells. They're what we call neurotransmitters. So it was proposed back then. There might be an abnormality of one of those chemicals that might be involved in depression. But it wasn't sort of widely popularized. It was a theory that was circulating within psychiatry and within academic research circles. There was a lot of research done to look into it in the 1970s, sponsored by the US National Institute for Mental Health. And that didn't report any findings. And I would assume, therefore, didn't find evidence of any abnormalities.

7:53So it was sort of, you know, going into decline. The idea was going into decline in the 1980s. And then the pharmaceutical industry recruited the idea to market their new range of drugs, the SSRI antidepressants, which they brought out at the end of the 1980s. Prozac was the first one that you mentioned earlier, and then there were a range of others that were brought in in the 1990s. And the industry wanted to persuade people that these drugs were different from the old benzodiazepines. They weren't just numbing you or tranquilizing you. They were doing something really important. They were targeting that you had an abnormality in your brain, and they were going to target that and put it right.

8:38Dr. Mark Hyman:And that benzodiazepine is like a Valium, and that was a big drug in the 60s that was used for almost every housewife in America as a way of just keeping them calm and subdued and sedated. But that's that big class of drugs. So that was the first psychiatric drug, really. Yeah, yeah. And they were enormously popular, very widely prescribed, but they'd got a very bad reputation by the mid-1980s because it became clear that they were highly dependence-inducing substances. So the pharmaceutical industry wanted to put clear water between the benzodiazepines and their new drugs. And so they came up with this idea to persuade people they've got this chemical imbalance and they need to take the drug to rectify this.

9:20They need to take it in a medical sense to put something right in their brain biology. So that's where it came from. And And they just put so much money into marketing these drugs. That message was said again and again and again in advertisements in online sites. It was supported by medical institutions who also told people that depression was caused by a chemical imbalance. And there was never really any good strong evidence to support it. And yet it caught on because it was just so widely disseminated.

9:58Dr. Mark Hyman:It's true. And I think when you're a busy doctor and these drug reps come in, and I remember this when I was in practice early on, they'd come in and they'd have their scientific papers and they'd have all their slides and their graphics and their impressive data. And you don't always have time to read all the literature as a doctor. You're sort of going, okay, this makes sense. My patients are suffering. This sounds like a good idea. But it turned out there was just very little evidence that it actually worked. And when you look at the studies, they kind of are rigged. I would say rigged in many ways, the way they design them, the way they do them, the way they try to control the outcomes and write them up.

10:38Dr. Mark Hyman:And when I started looking into this, when I wrote my book, The Ultra Mind Solution in the mid-2000s, I was shocked to find that there was very little evidence that these actually worked and that they didn't really work much more than placebo for mild to moderate depression. and yet they were being prescribed like water. I think one of the reasons that idea about the chemical imbalance and the drugs correcting it caught on is because it's so simple. You know, it's, yeah, it seems to make sense and you can show it with these nice diagrams. And so I think it was sort of really compelling both for doctors and for patients or potential patients.

11:17But you're right, the actual trials that were set up to demonstrate that antidepressants were effective really show that they have little benefit. They are minimally different from a placebo, you know, and that's just taking them as they are set up. But then, as you say, they're actually rigged in various ways. They recruit people who often want some sort of drug treatment. So they're hoping to get it. They're not completely double blind. That means that the The people getting the real drug and the people getting the placebo tablet are not meant to know what they're getting. Of course, that's the whole point of these studies.

12:00But actually, people can often tell because, you know, antidepressants are active drugs. They're not just dummy tablets. And they make people feel different. They have side effects. They give you a dry mouth. They might make you feel a bit sick. And they might make you feel, you know, mentally a little bit different or a lot different depending on the drug. They have very varied effects, different antidepressants. And so they're not properly blinded. And the people who get the real drug get some side effects, think, wow, I've got the real thing. That's great. So they probably get an additional placebo effect, what we might call an amplified placebo effect.

12:43and that in my view easily accounts for the very small difference that you're seeing between the drugs and the placebo substances so yeah not really don't have many benefits but but but i think it's important to say that's not that doesn't mean they are placebos they are active drugs they do have side effects they do have effects i mean they do affect people's emotions most antidepressants seem to produce this sort of emotional numbing state, state of emotional numbness, which in theory might be helpful if someone's intensely sad or intensely stressed. On the other hand, lots of people don't like that feeling of numbness and it doesn't seem likely that that's really going to be helpful to people in the long run to sort out their problems.

13:37If they can't feel anything, they can't feel happiness or joy anymore either. But the trials suggest that it's not really that useful anyway because there's so little difference between the antidepressants and the placebo.

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15:37Dr. Mark Hyman:And this is one that's been easy for me. Keep protein simple and go to paleovalley.com forward slash Hyman to save 15 % off your first order today. Well, it seems even worse than that because here you're promising somebody a drug to correct something that is a myth that doesn't really work and comes with a whole host of problems, which is anhedonia. You basically get these feelings of numbness and emotional numbing and also sexual dysfunction and low libido. How does that affect relationships? How does that cause even more depression? It's sort of like a vicious cycle. Yeah, it's just unbelievable, isn't it, that we're giving people things for depression that actually are going to numb your sex drive, interfere with your sexual functioning.

16:21They're going to make your life worse, in other words.

16:24Dr. Mark Hyman:And then they're really hard to get off of. They're not like you can just stop it like an antibiotic or any other, many other drugs. You have to taper off of them. It's complicated. There's often a rebound effect. You get serotonin syndrome. I mean, it's actually quite significant. It can be very serious. So can you talk about how in that way, they're not completely benign and that we need to think about how do we help people understand that? To start off with, I think presenting these drugs as drugs that have specific effects on underlying mechanisms like a chemical imbalance is really dishonest and prevents people from fully understanding what they're doing when they take an antidepressant.

17:06And that is they are taking a foreign chemical substance that alters the normal state of your brain chemistry and activity. And in ways that we don't fully understand and whose consequences we haven't fully worked out either. So they're doing something risky. When you mess with the stage of your brain, you're doing something risky. And I think if we said that to people straight up, at least that would be more honest. If we said what you're taking is a drug that's going to modify your normal biology in a way that we don't properly understand. I think people would then understand better that what they're doing is something risky.

17:50And as you say, some of the risks are things like sexual dysfunction, dependence problems, particularly for people who've taken antidepressants for years on end. They might well have difficulty coming off them. And sometimes they can, especially it seems if people come off too quickly, can get into a really bad state and have really bad problems. So it's very important to come off slowly if anyone's thinking about doing that. The most important thing really is that we should stop prescribing so many antidepressants in the first place, particularly to young women, to avoid these problems.

18:32Dr. Mark Hyman:Well, that sort of begs the question of like, you know, what is the right framing for mental illness and what are the root causes? And And it is true that we've gone through this period of massive pharmaceutical marketing to create a market. Literally, they made a market for these drugs. They convinced everybody they need them. They convinced doctors to prescribe them. And then people got on them and had a hard time getting off of them. And we're kind of in this pickle now where mental illness is on the rise. And yet, what are we going to do? What are we going to do and how do we address the root causes of this crisis?

19:11As you were suggesting, I think one of the origins of this problem is that we've developed a wrong-headed way of thinking about mental health problems. And it really sort of got going with this idea of the chemical imbalance. It was very interesting. When I was doing the research for the book, I went and looked at the archives of one of these depression awareness campaigns that was run by the Royal College of Psychiatrists in the UK in the early 1990s. And they did some market research before they started their campaign. Their campaign was to go and convince people that depression was a medical condition, go and see your GP, get treatment.

19:54Of course, it was partly funded by Eli Lilly, who were the makers of Prozac. But the market research they did was really interesting. They went out and they asked people, this is in about 1991 probably, what do you think causes depression? And people didn't say, you know, I think it's a chemical imbalance or a brain problem or a genetic problem even. They said unemployment, divorce, child abuse. and they said that they didn't think that taking a drug to deal with emotional problems was a good idea because it would just numb the problem and there was a potential that people might get dependent so people people had a different idea back then their idea back then was that depression is part of the range of our emotional reactions to the world and and i think we need to go back to that understanding that we that got buried by this campaign to medicalize depression and to medicalize other mental health struggles and difficulties

20:59Dr. Mark Hyman:i think that's an important point i think you know that you know humans are these incredibly emotive beings and we have a whole range of emotions throughout our lifetime and they're often situation dependent. You know, someone dies, you break up with a partner, you know, something tragic happens, there's an illness. You know, I just had a very close friend who just died. I mean, I understand, you know, when you start to feel these emotions and we just want to like placate them or subdue them or suppress them instead of actually feeling the full range of what it is to be a human being. And I think that's an important point.

21:36Dr. Mark Hyman:And often, you know, those are temporary situations. But there are also, I think, we live in a very stressful world right now geopolitically. Those things are real and they're destabilizing. I think there's divisiveness never before. There's increasing inequities in economics. There's challenges with chronic stress from social media and everything else. So we've got so many things that are making us mentally challenged. But I also think that there's another part of this, which is that there's a rise in the sort of biological factors that I think are actually a more accurate description of what's causing mental illness than a serotonin deficiency.

22:24Dr. Mark Hyman:and this is more sort of the work that i've sort of focused on around functional medicine and then there's been clinical trials for example called the smiles trial where you looked at people who were eating processed food getting them on real food randomized controlled trials showed that just eating a healthier diet actually helped with depression and i've seen this over and over my practice when you when you treat nutritional deficiencies whether it's b12 or folate or vitamin D or omega-3 fats. All of these have been linked to low mood or depression. So there's a lot of biological reasons. But I think when you say biological cause of depression, you're really focusing more on the sort of chemical imbalance framework and not these other aspects, which I think are pretty well understood.

23:08Dr. Mark Hyman:Is that right? Yes. Predominantly on these theories that depression is caused by deficiencies as a specific brain chemicals. But I worry that any sort of specific biological mechanism might be used in the same way. It might be used as a sort of way of suggesting that depression is, you know, is a physical and bodily thing and forgetting about the elements that we bring to our feelings and emotions that are about us as people rather than us as bodies. But I completely agree with you that one has to be physically healthy to have a sense of well-being, that if you are badly nourished or inactive, you are much more likely to be depressed or anxious or stressed.

24:08I mean, we know that there's lots of literature on that. And we know that doing exercise is really good for your mental well-being and also very good for depression.

24:20Dr. Mark Hyman:Yeah, exactly. Exercise is great for depression. Meditation is great for depression. Lowering stress levels is great for depression. Sleeping is great for depression. All these common sense things that we kind of forget. And I think, you know, it got exciting to think, oh God, I don't need to spend 40 years, five days a week doing psychoanalysis for treating my mental health. I can take this pill once a day and be done with it. But it's kind of been a, it's been an unfortunate trajectory because it hasn't allowed us to get to the real root causes. And you also talk about the sort of the social factors, right?

24:51Dr. Mark Hyman:The poverty, the housing instability, loneliness, childhood trauma. I mean, I think we've kind of distracted ourselves from some of this contextual stuff and are trying to sort of almost blame the individual rather than understand the social and political environmental causes. So I'd love you to sort of speak about that because I think this is a really important framing. Well, yes. And you were talking earlier about what's going on in the world and how frightening that is and how stressful that is. And, you know, we can add to that the sort of social and economic chaos that we've seen over the last, you know, 15 years or so since the crash, since the economic crash of 2008.

25:31and I would add to that that I think there's a you know that a lot of people have this feeling that there's nothing they can do about these events that there's no way to change them and and you know I think that's partly a consequence again of of changing social conditions of the you know loss of community people you know families and communities being much more fractured and dispersed than they were trade unions not being very powerful anymore more organized religion, having much less role in society and in people's lives. So I think on top of all the stresses that we're dealing with, people just can't see a way to change the world, not only to change the world, but just to change their world, to change their environment.

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26:22And so I suppose there's a degree of learned helplessness that people are experiencing that feeds into mental health problems. And I completely agree with you that the problem with this medical model that we've got and with encouraging the idea that you can treat depression with a pill is that it discourages people themselves from trying to work out what they might be able to change about their own lives, how they might be able to improve their own lives, how they might be able to take an active role in their recovery. and discourages governments from asking why so many people are depressed and unhappy and introducing social policies that might improve people's living conditions.

27:13Dr. Mark Hyman:It's really interesting. I think those are all so essential things. I mean, we have to deal with the social determinants of health. But, you know, there's also the commercial determinants of health. I don't know if you've ever heard that term, but it was sort of developed by the WHO. is a way of understanding the way in which corporations are determining our health through their actions, whether it's the ultra-processed food industry, tobacco, alcohol, pharmaceutical industry, all driving for profit and undermining public health. And I think these promote these ongoing social, political, and environmental causes.

27:50Dr. Mark Hyman:So it's just this really kind of almost disease-creating context we live in in the world today. And the individual is often at the effect of all this stuff. And unless you have some understanding of how to have agency and how all these things affect you, the average person has no clue that if they're eating ultra-processed food, it's going to give them depression. They may know it's not the healthiest for them. They may know it makes them gain a little weight, but they don't understand the full impact of these behaviors or things. And I think, you know, empowering people with agency, and you talk a lot about this, how do we have more agency and how do you help people have more understanding of what they can actually do themselves, in some ways to protect themselves from the onslaught, from the medical industrial complex and from the pharmaceutical, you know, industrial complex and the commercial interests that are driving towards people being unhealthy and increasing, you know, commercial benefit, but really undermining public health.

28:48Dr. Mark Hyman:So how do you help people think about that on an individual level? You're a psychiatrist. I mean, this is kind of how you have to think about these things. So we have a food industry that, as you say, is thrusting ultra-processed food at people, making people unhealthy. And then we have the pharmaceutical industry that's coming up with drugs that, you know, anti-obesity drugs. It's a great business model. weight down yeah exactly as well as antidepressants to deal with the fact that you know when you're unhealthy and overweight you're much more likely to be unhappy as well so we've got all these you know different different huge commercial sectors working in synergy with each other almost it's maybe gonna be a new drug ozempic combined with prozac yeah yeah yeah yeah don't even don't even put that out there i'm sort of someone's i know but this is how pharmaceutical industry thinks they're trying to manufacture illnesses and they've done this i've seen this happen throughout my career and we graduated medical school around the same time and it's like it's sort of the sort of medicalization of problems is sort of what you're talking about um and and this medicalization undermines our ability to really look at you know when one of the one of the bigger context issues that we just talked about.

30:05Dr. Mark Hyman:You know, one of the things that I see emerging, I love your perspective on this because it does kind of, it's kind of nagging me in the back of my head because I don't quite understand it. And there's this sort of psychedelic revolution going on in psychiatry, and there's a lot of work being done in the UK and a lot of the US and a lot of clinical trials. And the orders of magnitude of improvement is so far greater than placebo and then antidepressants and other psychiatric medications for PTSD, for anxiety, for depression, psilocybin, MDMA. Even now, Ibogaine is being talked about more, which is a root medicine from Gabon in West Africa that has profound neurochemical effects.

30:49Dr. Mark Hyman:And I've actually even taken it myself, and I can tell you it is profoundly neurochemically altering, not just in the moment, but it seems to have lasting effects around trauma and brain repair and brain trophic factors to get released. And I wonder how you think about that because in some ways, it is a biological framework for understanding how to treat disease. And the interesting thing about these compounds is that it's not like an antipressant where you have to take one a day for the rest of your life. It's a couple of treatments or not that many that seem to have really profound, long-lasting effects.

31:25Dr. Mark Hyman:So I'd love your perspective on that. I don't know if it's an area you think about, but it's just kind of, as you're talking about the biology of this, I'm thinking, oh, wait, you know, maybe we should talk about this. No, no, absolutely. I do think about it because they're also very popular or becoming popular in the UK, this whole area of psychedelic medicine. So this is how I think about it. I think that we need to think about all the drugs we use, that whether we use them recreationally or whether they're prescribed, if they're drugs that cross the blood-brain barrier, they're drugs that alter our mental states in one way or another.

31:59And that's how I think we should think about all drugs, rather than as things that target underlying pathological mechanisms. Because no drug that we use for mental health, whether that's antidepressants or antipsychotics or Valium or mood stabilizers or anything else, has been shown to actually do that, to work in that way. um so psychedelics are psychoactive substances they are psychoactive substances that give people a very unusual experience and some people find that experience to be enlightening and to give them insights into their lives and into their pasts that might help them going forward and the The original introduction of psychedelics into psychiatry, original, they were sort of reintroduced maybe a decade or so ago in the context of what was called psychedelic assisted psychotherapy.

32:59And the idea was that you'd have one or two psychedelic experiences in a sort of clinical setting, and then you would process your experience, what you might have learned from that with a therapist. And the idea was that for some people, there would be insights that would help them to get over what they were suffering from and to move forward in their lives. the problem is that model isn't isn't great for people who want to sell psychedelics or psychedelic experiences because it's just once or twice that you're going to take the things and um you know if you're setting up a psychedelic clinic like with the ketamine clinics that have got going in the states you wanted people to keep coming back you want an annuity but that's not how

33:49Dr. Mark Hyman:we should be practicing medicine it's like it's like we give an antibiotic for an infection we know it's only for a week and that's great. You're not going to take antibiotics for the rest of your life. So I think most doctors probably do care about doing the right thing. It's just the system is set up not for that. And so what has happened with ketamine, which was set up with the same sort of model, same idea in mind, is that the psychotherapy has gradually dropped away and people are encouraged to and certainly have got into the habit of going back repeatedly for their shots of ketamine. And so it becomes a long-term treatment.

34:23And we have no idea about the safety or, well, actually, we do have some idea about the lack of safety of long-term ketamine use, because we've got data from recreational drug users on how it damages your bladder and things. We don't have terribly good data on long-term repeated use of other psychedelics, because they're not so often used in that way. So that's my concern about psychedelics. I think the idea that some people get insights from using them is fine, but I worry that we will end up with the same old model of people just going on to chronic long-term treatment because that's what makes organizations money without knowing very much about the possible negative consequences of doing that.

35:11Yeah, although you can go to work on Prozac.

35:15Dr. Mark Hyman:You can't go to work if you take a big dose of mushroom or MDMA. But of course, this microdosing idea has come in, hasn't it? What do you think about the microdosing? I mean, I think you look at the literature on the toxicity of these drugs, like not MDMA particularly, but like psilocybin or LSD, there seems to be a very low toxicity and very high safety threshold for these drugs. So microdosing as a therapeutic option is something that's interesting. And I've been talking to some scientists about it. It seems that there's some increasing, you know, both anecdotal and clinical literature on this.

35:48There's a film, there's a Swedish film that's come out recently, which is about, I'll try and remember the name of it before I finish, which is about a group of teachers who decide to go to work having had a glass of wine or a small amount of beer or something like that, having had some alcohol. And their theory is that if they just have a small amount and maybe have to top it up a bit during the day, they'll be at that lovely sweet spot where they're confident and outgoing, but not too drunk. And the film is about how that goes horribly wrong, really.

36:26Dr. Mark Hyman:Well, microdosing alcohol, I don't think is a good strategy because we know that's a lethal poison. But the point is that, you know, I think these ideas are fine, but actually, when you're dealing with, you know, psychoactive substances, it's maybe not so easy to, you know, to control it in that way or to get the sweet spot exactly. And we don't, as I've said, you know, we just don't have any good research on the long-term effects of regular daily use of psychedelics, which hasn't been how they've been used traditionally. it's true i agree i mean but it sort of lets me sort of wonder about the the the brain effects uh these compounds and and how they're they are altering brain function they're altering brain structure they they increase neuroplasticity neurogenesis um and also neurochemistry in ways that seem to have like lasting effects and i i don't um i don't know how to comport that with the sort of the what you're talking about which is sort of this sort of failure of this chemical theory of mental illness maybe we're just thinking about it wrong i don't know how to think about it i love your sort of advice on that well well i i worry about all these um ideas that they're enhancing neuroplasticity i don't think there's actually that much evidence that they are but if they are if there is research showing that it's not necessarily a good thing because because often you're seeing neuroplasticity, neurogeneration when you're getting damage.

37:57There was a suggestion that antipsychotics and antidepressants improve neuroplasticity, but we know, and the evidence that was offered was that they're altering some growth, some nerve growth factors, but actually we know those are altered in the same way by having a stroke or having a brain injury. So it doesn't necessarily show that the drugs are doing, you know, something that's good. It may be that they're harming the brain. And what we're seeing is the brain's reparative mechanism.

38:29Dr. Mark Hyman:No, that's interesting. That's one. It's so complicated, isn't it? I mean, I want to pivot a little bit because you do talk about this sort of drug centered model versus a disease center model. I'd love you to sort of unpack that. I don't quite think about people are familiar with that. I'd love you to sort of explain your view on this. The conventional way of thinking about drugs like antidepressants is this idea that they are working by targeting some underlying biological mechanism that leads to the symptoms of depression. That's often been said to be a deficiency of serotonin, but it could be some other abnormality.

39:09So people have recently proposed abnormalities in inflammation and they may be related somehow to how antidepressants are having their effects. But it's that basic idea. And what I'm saying is that antidepressants, like alcohol, like cannabis, like psychedelics, are mind-altering substances. They change the normal state of our brain chemistry and our brain activity, and they therefore change our underlying thoughts and thought processes, feelings, sensations, etc., in more or less subtle ways. So I'm not saying antidepressants are exactly the same as alcohol. Of course, they're not. They're different sorts of chemicals.

39:49They have different sorts of effects. And some antidepressants have quite noticeable effects. Maybe people feel quite different, quite groggy, lethargic, for example. And some of them have much more subtle effects. And one of the effects they have is this emotional numbing effect. but so that's that's what i've called a drug-centered model of drug action that is understanding these drugs as drugs as foreign chemical substances that induce mental alterations that are then superimposed onto people's underlying feelings in the same way that that the effects of alcohol are so you know we know that if you might be feeling down you go out and you have you know a few drinks, temporarily you might then feel better because of the effects of alcohol.

40:39That's not because it's rectified a chemical imbalance. It's certainly not because it's rectified an alcohol deficiency. It's because the characteristic alterations induced by alcohol is temporarily superimposed onto your underlying feelings.

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42:50Dr. Mark Hyman:And because they're chews, not pills, they're convenient and delicious. Perfect for your bag, your desk, or wherever the day takes you. If you want a simple way to support resilience, energy, and focus this summer, try HTB Immune Energy Chews. Go to BigBowlHealth.com slash DrHyman, that's D-R-H-Y-M-A-N, and use the code HYMAN15 to save 15 % off your first order. And how does that sort of connect to the drug-centered versus disease-centered framing of mental health? So what I'm saying is that drugs like antidepressants have been misleadingly portrayed as having these disease-centered or disease-targeting effects, whereas actually the way we should understand them is having drug-centered effects as being drugs that produce alterations to our normal or undrugged states.

43:45Dr. Mark Hyman:Which makes a lot of sense. So given all that, what's a more honest look at mental health today in terms of an evidence-based model of what mental health care and mental health approach to mental illness could be? The first thing to say about an honest approach is that we really don't have evidence to conclude that any sort of mental health condition, but particularly things like depression or anxiety, are biological diseases in the sense that Parkinson's disease is a biological disease. We haven't detected any underlying disease processes that might explain or count for the symptoms. And there are other ways, as we've discussed, of understanding the distress, the sadness, the unhappiness, the despondency that people go through at different times in their lives.

44:40So I think that's the first thing to say. And then also that we have been misled about the nature of the drugs that are prescribed for mental health problems into seeing them as these specific, targeted, sophisticated substances, whereas actually what they're doing, like alcohol, like other recreational drugs, is inducing an altered artificial mental state that may temporarily suppress underlying feelings, but it is not resolving anything.

45:11Dr. Mark Hyman:Like a band-aid. Yeah. Just to emphasize this, I'm not trying to, because I think this fits in with some of your views as well, I'm not trying to suggest that the brain is irrelevant. We are biological creatures. We're embodied creatures. And the reason that we have the range of sophisticated and refined emotions that we do is because we have such large brains, such large and complex brains. It's our large brains that enable us to interact with the environment in a super sensitive way and flexible way. That kind of begs the question of what now? If these drugs are not the answer, what is? And how do we support people with depression without defaulting to antidepressant medication?

46:00I think we need a really radical change in how we approach mental health problems. This medical model encourages us to see us in the health professions to see ourselves as treating diseases. But what we should be seeing ourselves as doing is helping people with their individual problems. I think if you get away from that disease model, then you can understand that everyone who is depressed is depressed for different reasons. There are different causes for everyone. There are as many causes of depression as there are people with depression. And we need to help people with their individual situations to identify why they are feeling as they feel now and what can be done to change that.

46:54And it's not complicated to do that, but we're so entrenched in this medical framework that that sort of forces us down the route of thinking that we're treating some thing that is somehow the same, some condition that's somehow the same in everyone who has it. that we are failing to treat people as individuals often and to really identify what their problems are. I mean, I think this happens, you know, this is happening out there in the community as well, because people I find, and I'm sure you find the same, you know, will often come to me saying, oh, you know, I think I've got depression. I think I've got ADHD.

47:33I think I've got this. I think I've got that. I think I've got, yeah, you know, a diagnosis that they might have sort of spent quite a lot of time looking up. And it can be quite difficult then to get underneath this label that people have decided they have to find out what the actual problems are, what are the difficulties that they're having with their day-to-day life. Just wanted to add something more to that because people often say to me, well, that's all very well for a lot of people, but what about people who have really severe depression or have depression when there doesn't seem to be any obvious cause, any obvious reason for them to be depressed.

48:14So I'd just like to address that because I think that's important.

48:18Dr. Mark Hyman:That was going to be my next question. It's important to say that there is no evidence that severe depression is caused by any specific biological mechanism either. But of course, we're all different and some people will react to possibly quite trivial problems in their lives in a much more severe or intense way than other people will. And so there are some people, obviously, who get into a really bad state, who take to bed. Sometimes they refuse to eat or drink. Some people get sort of depressive delusions. And in that situation, we need to make sure that we take care of people. the evidence that antidepressants are any use in that situation is no better than than in any other situation they're not they haven't been shown to have um you know clinically relevant substantial effects in people with really severe depression any more than they have for people with milder milder episodes of depression but it certainly is important that we help and take care of people in that situation because they can, well, often they can't take care of themselves.

49:33And, you know, sometimes people can try and commit suicide. So it is important to keep people safe and to remember that almost everyone will come out of it eventually. Most people will recover from depression eventually, naturally in their own time, hopefully helped by being cared for. And as soon as they're able to do it, being helped to identify things that might improve their situation. Because even people with this very severe depressive reactions are often reacting to circumstances. So it's quite typical, people who get into this severe state, it's quite typical that they're older people who have just been affected by a bereavement, loss of their spouse or other loved ones, or retirement is another thing that can trigger these sort of episodes.

50:24Dr. Mark Hyman:People listening are going, well, gosh, if these things don't work and there's$20 billion of these drugs prescribed here globally, millions and millions of people are taking them and they're listening, what do they do? And how do you responsibly deprescribe them? And how do you support them as they're getting off of them? And how do you direct them to resources that can actually help address those underlying causes? First of all, it's important that people take their time to think about it and think about how the drugs are affecting them, the pros and cons of those effects. And then if they decide that and read up about the side effects that they might be experiencing, because sometimes people are getting side effects and they're not aware that it's, you know, they're not aware that it's the drug that's making them feel sleepy or groggy or maybe be interfering with their sleep.

51:16And then if people decide that they do want to come off the drug, I would suggest that people go and see their doctors. Hopefully the doctor will be sympathetic and will draw up a plan with you to come off it slowly and sensibly. If your doctor tells you to come off in two to four weeks, don't take their advice, particularly if you've been taking these drugs for years at a time because you may end up in a really bad state. There's information for people out there now about how to come off antidepressants safely. A colleague of mine wrote something called the Maudsley Deprescribing Guidelines that gives really detailed evidence on how to reduce doses gradually if you're experiencing difficult, significant withdrawal effects.

52:07So yes, so the main evidence is don't do anything in a hurry, make a plan, try and get support from your doctor or from some health professional, and come off slowly, particularly if you've been taking the drugs for a long time.

52:23Dr. Mark Hyman:And then what do they do on the other side of that? Because people are saying, well, great, I'm going to get off this drug, but I'm going to be depressed. You know, what do I do? So yeah, that's a really good question too. And also during the process of withdrawal, people might feel one of the withdrawal symptoms is to feel sort of really intense emotions, tearfulness, anxiety, all those things can happen during withdrawal. And often people will assume that they're having a relapse because of those emotional symptoms. But those symptoms can be part of the withdrawal process. And to the extent that they are part of the withdrawal process, they will gradually fade as the body gets used to not having the drug in the system anymore.

53:07So that's the first thing. Then the second thing, if people are still depressed, is the same advice as I would give to people who are depressed for the first time and thinking about possibly going to see their doctors. The most important thing is to try and identify why you feel as you feel. What is it in your life? What is this emotion signaling to you? What is it in your life that is getting you down and that you might be able to change to improve how you feel? That's the first thing. The second thing is, as we've been saying earlier, take exercise, eat well, optimize your physical health because that will make you feel better mentally and emotionally?

53:52Dr. Mark Hyman:I think that's important is that, you know, we have to lean in on the things we know have been scientifically proven to work. Eating a whole real food diet, regular exercise, especially cardiovascular exercise, getting adequate sleep and circadian rhythm regulation, managing stress, and just learning how to regulate your nervous system. And then there are other things that are easily addressed, you know, whether they're nutritional deficiencies, which are extremely common, whether it's omega-3s or vitamin D or folate or B12, things we know from the scientific literature do actually impact you.

54:25Dr. Mark Hyman:And then there's, you know, the whole other layer of things that can cause depression that we know can drive inflammation in the brain, whether it's the microbiome changes that we now are understanding, whether it's environmental toxins. So there's actually a pathway, and it's what I've spent a lot of my life thinking about. And I think, you know, it sort of speaks to sort of really reframing the narrative of mental health from this sort of idea of some chemical imbalance, which was sort of the framework of your book, to really a more sort of holistic view of understanding of health, both from the sociological, political, environmental aspects, and some of the other biological factors around lifestyle that we're just ignoring.

55:04Dr. Mark Hyman:And I think that's a really important moment, I think, in psychiatry. It feels like a really historical moment where we're basically understanding, one, the degree of which trauma affects us from our childhood. And two, I think the psychedelic revolution is also opening up a different perspective of how do these things work. And I think we're sort of entering a new era of psychiatry and mental health. And hopefully, it's not like just like, okay, well, Prozac didn't work. Let's just stop it. And then you're all like kind of left-hand holding the bag. I think that's a depressing thought literally in itself.

55:37Dr. Mark Hyman:So I think it's kind of a hopeful moment. Do you feel hopeful about the future of psychiatry? Possibly. I'm not sure. The backlash I've had to both the book and the FDA panel on pregnancy is a bit depressing. But I'm always hopeful at an individual level because I see people who sometimes have been depressed for years who do nevertheless manage to recover the agency to overcome what they're feeling and to make changes and to feel better. I see that all the time. And I think, you know, this is what I object to. What I object to most about telling people that they've got a chemical imbalance is that that is a really depressing message.

56:21That's telling people there's something wrong with your brain. There's nothing you can do about it. You've got to rely on, you know, someone giving you a drug. And so I think just correcting that mistake and informing people that there isn't something wrong with their brains and that they do have the capacity to improve, to recover, to change is actually a positive and a hopeful message.

56:47Dr. Mark Hyman:Amazing. Well, everybody definitely should take that to heart and should check out your new book, Chemically Imbalanced, The Making and Unmaking of the Serotonin Myth. It was definitely a wrong left turn that we took in the 90s. And I think, thank you for helping us correct it and rethink our approach. I really appreciate your being on the podcast. Is there any final words or thoughts you'd like to share with our audience? I suppose inform yourself because, you know, especially with the backlash I got to the book, I realized that there are elements of the medical profession that don't want people to think for themselves, that want people just to go on, you know, believing expert pronouncements about things which are not always accurate.

57:29I know that's a scary message, but I think we need to be informed as patients, as consumers nowadays, we need to inform ourselves and not just take things on trust. We have been essentially lied to about the nature of depression for two and a half decades now. So yeah, people need to do their own research and not just take things on trust as we may be used to.

57:58Dr. Mark Hyman:I think we're in that moment in medicine where people are wanting to have more agency, are less sort of idealizing the sort of medical profession as a know-it-all profession. And sort of the emperor has no clothes a little bit here. And I think it's important, not that medicine doesn't have a lot of value and that we've both been trained in traditional healthcare and medicine. And it does have a lot of really good things about it. And doctors are generally very compassionate, kind, good people who want to do well for their patients. It's just that even our own profession has been hijacked in ways by commercial interests that leave us not knowing what's true sometimes.

58:37I think people need to realize there are areas of debate and discussion within medicine. And, you know, things aren't necessarily as clear cut as the media and scientists themselves sometimes portray them.

58:51Dr. Mark Hyman:Absolutely true. And thank you for having the courage to take on something that's quite controversial and challenging the orthodoxy and moving science forward. I really appreciate your work. And it kind of validates what I was even seeing almost 20 years ago. There were early signs in the literature that even in the 2000s, it was like, wait a minute, this isn't quite what it was promised to be. So thank you for doing the hard work and making people like me look smarter. Thank you. Thank you, Mark. It's been a real pleasure. If you love this podcast, please share it with someone else you think would also enjoy it.

59:27Dr. Mark Hyman:You can find me on all social media channels at Dr. Mark Hyman. Please reach out. I'd love to hear your comments and questions. Don't forget to rate, review, and subscribe to The Dr. Hyman Show wherever you get your podcasts. And don't forget to check out my YouTube channel at Dr. Mark Hyman for video versions of this podcast and more. Thank you so much again for tuning in. We'll see you next time on The Dr. Hyman Show. This podcast is separate from my clinical practice at the Ultra Wellness Center, my work at Cleveland Clinic and Function Health where I am Chief Medical Officer. This podcast represents my opinions and my guests' opinions.

59:57Dr. Mark Hyman:Neither myself nor the podcast endorses the views or statements of my guests. This podcast is for educational purposes only and is not a substitute for professional care by a doctor or other qualified medical professional. This podcast is provided with the understanding that it does not constitute medical or other professional advice or services. If you're looking for help in your journey, please seek out a qualified medical practitioner. And if you're looking for a functional medicine practitioner, visit my clinic, the Ultra Wellness Center at ultrawellnesscenter.com and request to become a patient.

1:00:27Dr. Mark Hyman:It's important to have someone in your corner who is a trained, licensed healthcare practitioner and can help you make changes, especially when it comes to your health. This podcast is free as part of my mission to bring practical ways of improving health to the public. So I'd like to express gratitude to sponsors that made today's podcast possible. Thanks so much again for listening.

From the publisher

For decades, depression has often been described as the result of a chemical imbalance in the brain. But how strong is the evidence behind that idea? This episode explores one perspective on an area of medicine that continues to be actively debated and is intended to encourage thoughtful discussion—not to provide individualized medical advice.

Today on The Dr. Hyman Show, I'm joined by psychiatrist and researcher Dr. Joanna Moncrieff to examine the science behind the serotonin theory and explore how it shaped modern mental health care. Together, we consider why rethinking our assumptions may open the door to a more complete understanding of depression and recovery.

We discuss:

• Whether depression is best understood through the lens of a chemical imbalance—or something far more complex

• How the serotonin theory shaped modern psychiatry and why it's increasingly being questioned

• What current research says about antidepressants, emotional numbing, and informed consent

• Why lifestyle, nutrition, trauma, and social connection deserve a larger role in supporting mental health

• How a more individualized, whole-person approach could change the way we think about depression and recovery

Mental health treatment is deeply personal, and this episode explores one perspective on an area of medicine that continues to evolve. If you're currently taking antidepressants or other prescription medications, don't stop or change your treatment based on this discussion alone. Instead, use it as a starting point for an informed conversation with your healthcare provider.

Learn More: Dr. Moncrieff recently participated in an FDA Expert Panel on SSRIs and Pregnancy. If you'd like to explore another perspective on the evidence discussed in this episode, you can watch the panel here.

View Show Notes From This Episode

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(0:00) The impact of the chemical imbalance theory and myths of mental illness

(2:02) Disclaimers and introduction of Joanna Moncrieff

(3:00) The serotonin myth, antidepressant use, and marketing of SSRIs

(16:12) Risks, side effects, and wrong-headed approaches to mental health

(21:00) Societal, biological, and lifestyle factors in mental health

(27:13) Commercial determinants of health

(30:49) The rise and implications of psychedelic treatments in psychiatry

(43:21) Drug-centered vs. disease-centered models in mental health

(45:40) The role of the brain and alternative approaches to treating depression

(50:00) Addressing severe depression and strategies for deprescribing antidepressants

(54:41) Reframing mental health narratives and future outlook

(57:09) Encouraging self-education, debate, and discussion in medicine

(59:23) Closing remarks, disclaimers, and gratitude to sponsors

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