In short
Podcast Summary: The Dr. Hyman Show - Episode with Fidji Simo
Episode Overview Title: How OpenAI Is Helping People Take Control of Their Health Guest: Fidji Simo, CEO of Applications at OpenAI Description: This episode discusses how AI can shift medicine from treating symptoms to restoring the underlying systems of health. Dr. Hyman and Fidji Simo explore chronic illness misunderstandings, fragmented health data, and the possibilities of comprehensive health insights through technology.
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Key Concepts Discussed
- The Misunderstanding of Chronic Illness
- Diagnosis does not always explain the underlying causes of symptoms.
- Chronic illnesses are often misunderstood, leading to ineffective treatments.
- The Role of AI in Healthcare
- AI can empower personalized medicine by connecting various health data (labs, lifestyle, history) to reveal insightful patterns.
- OpenAI's ChatGPT Health aims to facilitate proactive health decisions through comprehensive data analysis.
- Moving from Reactive to Proactive Care
- Health should not be solely managed in a doctor’s office; creating the right environment is crucial for well-being.
- AI can assist in making better decisions about food, sleep, and other lifestyle factors.
- Empowerment through Data Integration
- Connecting personal health data—including lab results and lifestyle choices—can lead to a deeper understanding of one's health.
- Individuals should have access to their health information to make informed decisions.
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Key Takeaways
- Importance of a Holistic Approach: Current healthcare often treats separate parts of the body in isolation rather than seeing the body as a comprehensive system.
- AI as a Tool for Empowerment: AI can help individuals become better informed about their health, leading to improved health outcomes.
- Future of Health Management: The integration of AI into health management can create a personalized health assistant, guiding individuals daily based on their health data.
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Major Discussions
Fidji Simo's Health Journey
- Fidji shares her personal health struggles, which began after her pregnancy, leading to a diagnosis of a neuroimmune condition.
- Her experience highlights the inadequacies of the healthcare system in approaching chronic illnesses comprehensively.
AI's Transformative Potential
- The integration of AI can potentially streamline access to health information and reduce the administrative burden on healthcare providers.
- OpenAI's initiatives aim to defragment health data, making it easier for both patients and doctors to access and understand health information.
Chronic Conditions and the Need for Data
- Many chronic conditions are poorly understood, and there is often a lack of research investment due to insufficient data.
- Chronicle Bio, a company founded by Fidji, seeks to collect extensive biological data from patients to better understand chronic conditions and find targeted treatments.
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Conclusion Fidji Simo emphasizes that the future of healthcare lies in empowering individuals to understand their health better and take proactive steps toward wellness, aided by AI. The discussion underscores the importance of viewing health as a system rather than isolated symptoms, and the potential for technology to revolutionize health management.
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Additional Resources
- Free Weekly Health Tips from Dr. Hyman: [Health Tips](https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast)
- Join the Hyman Hive for Expert Support: [Hyman Hive](https://drhyman.com/pages/hyman-hive)
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Sponsors
- Sunlighten
- Paleovalley
- PerfectAmino
- Seed
- Made In Cookware
- Fatty15
Visit their websites for special offers and discounts mentioned in the episode.
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This summary encapsulates the key themes and discussions from the episode featuring Fidji Simo, emphasizing the transformative role of AI in healthcare and the importance of personalized health management.
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VOUnderstanding Health Navigation Challenges
0:45 to 1:49
Discussion on the common issues people face in navigating their health information.
“The resident was actually totally relieved because she told me, I have five minutes to make the round.”
The Role of Infrared Sauna Therapy
1:49 to 2:24
Exploration of the benefits of infrared sauna therapy in health detoxification.
“As we head into a new year, a lot of us feel that natural pull to reset, to feel lighter, clearer, and more energized.”
AI's Potential in Health
3:50 to 4:36
Discussion on how AI can revolutionize health management and personal understanding.
“And you are launching as your first initiative, the health focus of ChatGPT was ChatGPT Health.”
Personal Health Journeys
4:36 to 7:01
Fidji shares her personal health challenges and motivations related to AI in healthcare.
“Because we both kind of have a similar history of having a condition that's poorly understood, that's poorly diagnosed, that's poorly treated, that causes a lot of pain and suffering.”
Systemic Issues in Healthcare
7:01 to 11:00
Exploration of the shortcomings of the current healthcare system and the need for reform.
“Because we're looking at things through the wrong lens.”
Connecting Data for Better Health
11:00 to 13:32
Discussion on the importance of connecting health data for improved diagnosis and treatment.
“All of these multi-systems, they are not focused on one organ.”
AI Enhancements in Personal Health
13:32 to 14:01
Fidji shares personal experiences of using AI to analyze her health data and derive insights.
“The main thing is exactly what you said.”
AI in Personal Health Management
14:01 to 16:16
Explore how AI, specifically ChatGPT, can assist in managing personal health data and treatments.
“So that has been really helpful in like finding new avenues to explore, getting new ideas, not having to read all of the, you know, studies coming out because like, who has the time?”
Insights from Personal Health Data
18:05 to 24:13
Delve into how personal health data can reveal patterns and improve health outcomes.
“It also detected that, you know, I needed like B vitamins that were methylated and like things that doctors hadn't dug into.”
The Future of Preventative Health with AI
24:13 to 28:00
Discuss the transition from sick care to preventative health through AI innovations.
“So that gives you a sense like of the scale that this is already operating at.”
Show all 27 chapters
Integrating Health Data for Personalized Care
28:00 to 30:16
Learn how partnering with various health data providers can create a comprehensive view of individual health.
“to me is we're going to be able to help people understand not just to treat disease or prevent disease, but how do we actually create health?”
The Role of Nutrition in Health Management
30:16 to 33:00
Discover how technology can simplify nutrition choices and make healthy eating more accessible.
“I mean, in getting people all the way down the pathway, not just understanding what's going on, it's just having an assessment of what their disturbances are in their health or simple things they can do.”
Empowering Patients with AI in Healthcare
33:00 to 35:31
Understand how AI tools can enhance patient engagement and improve health outcomes.
Accelerating Drug Discovery through AI
35:31 to 36:52
Explore how AI is revolutionizing the process of drug discovery and development.
“more informed because to your point, they cannot read the thousands of studies that come out every week.”
The Future Paradigm of Medicine
36:52 to 39:29
Learn about the shift towards a systems-based approach in understanding health and disease.
“us to massively accelerate the pace at which scientific discovery happens.”
The Promise of Big Data and AI in Healthcare
39:29 to 42:00
Discover how big data and AI can help us identify specific patient needs for better treatment.
“and I'm giving lectures about this guy who drops his keys on the street.”
Revolutionizing Patient Treatment with AI
42:00 to 43:34
Explore how AI can identify specific patient populations for better treatment outcomes.
“And the reason is there wasn't enough segmentation of the patients to realize, okay, on those, it's going to be miraculous.”
Democratizing Health Information Access
43:34 to 45:23
Learn how technology is changing access to health information and empowering individuals.
“There's just, people are desperate because they're not getting the answers from the healthcare system.”
Innovations in Kitchen Tools and Healthy Cooking
45:23 to 47:26
Understand the importance of quality cookware for healthy cooking and the benefits of Made In Cookware.
“And it's kind of an exciting thing because all of a sudden it's going to democratize healthcare, decentralize healthcare, make it really affordable or often free for people.”
Chronicle Bio: Building Infrastructure for Cure Research
48:36 to 52:52
Delve into the concept of creating comprehensive datasets to accelerate health research.
“But I tried the integration with Function, which is very cool.”
Understanding Diseases through a New Lens
52:52 to 56:07
Learn about the need for a multidisciplinary approach to understanding and treating diseases.
“There's many diseases and each disease may have multiple causes and need multiple treatments.”
The Complexity of Disease and Understanding Health
56:07 to 57:27
Explore how a few laws can explain a myriad of diseases and health conditions.
“I mean, the French actually were pretty good.”
Trust and Utility in Health Technology
57:28 to 58:21
Discuss the importance of trust in health technology and how it can enhance user experience.
“For example, in my case, I have both endometriosis, which is considered a reproductive health problem.”
AI's Role in Healthcare and Physician Burnout
58:22 to 1:00:20
Examine how AI can improve healthcare delivery and address physician burnout.
“First off, you touched on it, but trust is really important.”
The Future of ChatGPT in Health Management
1:00:21 to 1:02:37
Envision how ChatGPT can become a proactive health management tool for users.
“ally and that the responsibility is on us, technology builder, to build it in a way that is responsible to really address their needs.”
Empowering Patients with Personal Health Data
1:02:38 to 1:05:00
Discuss the importance of individual health data in empowering patients and enhancing care.
“So we really hope that it can really help improve that relationship as well.”
Ending Suffering through Health Innovation
1:05:01 to 1:05:48
Explore the mission to alleviate unnecessary suffering through improved health technology.
“I totally agree with your point on tests.”
Transcript
Automatic transcript. May contain errors.0:00Most people know better how to operate their phone or their car than they know how to operate their body. 9 out of 10 people don't know how to navigate their own health information, and even most doctors probably don't. And so we have this moment in history where we're in there right now that's going to allow us to really unlock this. BG Simo is CEO of Applications at OpenAI, where she leads products like ChatGPT and oversees the company's global operations. Big job. She's a veteran tech leader and a former CEO of Instacart, and she brings deep experience building and scaling some of the world's most influential consumer platforms.
0:29I was hospitalized. I developed an infection and the nurse arrives and she's like, I need to administer an antibiotic. I put the name of the antibiotic in Chagipitini. And so it immediately told me, hey, this antibiotic is standard, but in your case, it might reactivate a really serious infection that I had had a couple years prior. So I said that to the resident. The resident was actually totally relieved because she told me, I have five minutes to make the round. I cannot look at someone's health records five years ago. And I'm really glad that she picked that up. One of the most important decisions of my life would have been kind of messed up if it wasn't for AI helping connect the dots.
1:08I had seen 20 doctors, but not a single one of them. I'd looked at the whole picture and was able to analyze all of this data and give me patterns that you can only detect when you see that whole picture. That confronted me to the healthcare system in a big way and realized all of the shortcomings of being able to treat chronic illness. There's a specialty for every part of your body, and there's literally a doctor for every inch of you. And I think what most doctors miss is the body's one network, and networks are hard to understand. And now with AI and with ChatGPT Health and with Function Health, we're able to start to gather our own data in ways we never could before.
1:49As we head into a new year, a lot of us feel that natural pull to reset, to feel lighter, clearer, and more energized. And it makes sense. Our detox pathways take a hit this time of year from stress, disrupted routines, and environmental exposures. The truth is, sometimes eating well isn't enough to fully support that reset. That's why in my 10-day detox, one of my favorite tools I always talk about is infrared sauna therapy. A high-quality infrared sauna helps your body eliminate toxins more efficiently by boosting circulation, supporting lymphatic flow, and creating a deep, productive sweat at a lower, more comfortable temperature.
2:21I personally love Sunlighten's infrared saunas. Their patented technology delivers the highest quality infrared and is backed by over 25 years of research. Sauna sessions can help reduce inflammation, balance cortisol, support metabolic health, and restore energy. If you're ready for a fresh start, visit sunlighten.com. You can save up to$1 ,400 plus get exclusive year-round savings with the code HYMAN. I travel a lot across time zones, through airports, in and out of events. And as you know, travel can be incredibly hard on the body. It also makes it tough to stay consistent with eating healthy.
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3:23If you want to avoid food emergencies on busy travel days, check them out at paleovalley.com slash hymen or use code hymen for 15 % off your first order. Welcome, Fiji, to the podcast. It's so good to have you. Great to be here. Thanks for having me, Mark. Well, everybody who's listening is probably wondering why I'm having you on the podcast about health. But as it turns out, you've just taken on the role of CEO of Applications at OpenAI, otherwise known as ChatGPT for most people. And you are launching as your first initiative, the health focus of ChatGPT was ChatGPT Health. To me, that's so exciting because you could have done a million things, but you're focusing on this really revolutionary approach to helping people understand their own health.
4:09Most people know better how to operate their phone or iPhone or their Android phone or their car than they know how to operate their body. And we were just chit-chatting a little before. We said 9 out of 10 people don't know how to navigate their own health information. And even most doctors probably don't. Honestly, it's hard when you're sick to figure everything out. And so we have this moment in history where we're in there right now. It's going to allow us to really unlock this. And your efforts are really accelerating this. And before we get into kind of what the potential is for AI and health and what the potential is for people to understand their health better to end suffering that we now have the answers to but they're not getting, I want to kind of talk a little bit about your suffering and my suffering.
4:54Because we both kind of have a similar history of having a condition that's poorly understood, that's poorly diagnosed, that's poorly treated, that causes a lot of pain and suffering. It's not in our head, but is a real phenomenon that happens that we haven't been able to help. You know, maybe you could start out by sharing a little bit about your health journey and how you got into all this and why this is so important to you. Because you're not just leading this from within AI, but you also have another company that's helping to sort of unlock the mysteries of chronic illness, which I got so excited about when I saw.
5:26Absolutely. So, yeah, to share a little bit about my own health journey, I was very healthy until I got pregnant in 2015. I had a pretty rough pregnancy. And then after the pregnancy, I started having all kinds of weird symptoms. I started fainting a lot, being very shaky, exceptionally tired. And as you can imagine, doctors at the time told me, you're just a tired mom. You're deconditioned. It's OK. Like, you know, nothing wrong with you. And I kind of miraculously recovered, you know, nine months later after the pregnancy. But a couple of years later, I had the surgery for endometriosis. And after that surgery, the same symptoms recurred.
6:07I started fainting a lot, started being very dizzy. My heart would go like super high as soon as I would stand. A constellation of like mystery symptoms. And that's when I was diagnosed with a neuroimmune condition called postural obstetrics, tachycardia syndrome, which is a mouthful that then evolved into chronic fatigue syndrome. And it's pretty debilitating. Like, you know, I am still dealing with the symptom and that means that, you know, I can't stand for long periods of time without fainting. I end up, you know, having, you know, fatigue much, much faster than normal people. And so, you know, that confronted me to the healthcare system in a big way and realized all of the shortcomings of being able to treat chronic illness.
6:55That's very frustrating as someone who's got access to anything, anybody, anywhere on the planet, and still not to be able to get answers. Because we're looking at things through the wrong lens. And, you know, I think, you know, in reading some of the work you've done, I encourage everybody to read your Substack article on Chattipty Health, which really lays this whole problem out. And you talk about how you went to different doctors for different symptoms, but you're one body. And everything is connected. And there are root causes. And there are fundamental biological systems. And I also, when I was younger, first got into all this because I ended up having chronic fatigue syndrome.
7:32I went from riding my bike 100 miles a day and, you know, being able to remember 30 patients charts without taking any notes all day to not be able to walk up the stairs or know where I was at the end of a sentence. It turned out I had mercury poisoning from living in China. And that's a whole long story. But my whole system just collapsed from one day to the next. I went to doctor after doctor. I went to Columbia. I went to Harvard. I'm sure as you did. And no answers. You know, oh, you're stressed. Oh, take some Xanax. Oh, take some Prozac, you know, like, you know, and I knew I wasn't crazy.
8:04And I was highly motivated, highly engaged person. And all of a sudden I could barely function. And it took me a long time to dig out of that. And I think, you know, what I discovered was that the body is this incredibly complex network. As an individual doctor, it's very hard to understand the massive complexity that's the human body. We've got 40 trillion cells. We've got billions of chemical reactions, billions of trillions of chemical reactions happening every second in the cell and the body. There's so much scientific literature, and no one person can put that all together. There is an operating system that we call network medicine or systems medicine that's preventive, proactive, predictive, participatory, as you've written about.
8:46And it's so good at helping people understand these complex chronic illnesses, but traditional medicine is just so slow to change. You know, as a doctor, I know that, you know, it took 50 years from the time Semmelweis discovered we should wash our hands before surgery till doctors believe that we should wash our hands before surgery, right? So it's kind of like that. And now with AI and with ChatGPT Health and with Function Health, we're able to start to gather our own data. We're starting to make sense of our own data in ways we never could before. So it's super, it's super exciting. And I think you've struggled even as a person, you know, who's had access to figure this out.
9:21And I feel bad because that's really what I get up every day. Because I want to have people be empowered to end needless suffering and to get help whatever they can from the world's, you know, incredible scientific knowledge that most of us don't have the ability to sort through, understand and make sense of. But now we're starting to be able to do that with AI and health, which is pretty exciting. And I'll tell you, I mean, what you're saying resonates so much. I saw 20 specialists, everyone looking at just like one particular symptom. And if you look at my disease, it's a mix of immune dysregulation, nervous system dysregulation.
9:55So that impacts the entire body. But meanwhile, you have the GI doctor that's just focused on your GI symptoms and cardiologist who's just thinking that your heart rate is fast, but not really connecting that with the fact that it's a neurological symptom. When I got diagnosed, it was interesting because I had this very naive idea that there were plenty of doctors behind the scenes who were all working to make sure that these conditions would get cured. And I realized, oh, actually, there isn't that much happening that can actually advance scientific discovery. So I ended up hiring a teaching assistant at Stanford to teach me genetics and basically the whole body system.
10:35But I'm like, that's crazy. Like who has the resources and the time to do that? And that's what made me so passionate about making sure that everyone can understand their own health, level the playing field with doctors, because ultimately it's your life, and really de-silo the healthcare system, which is not working as is. And especially when you look at like the burden of chronic illness in the country right now, about like 85 % of health care costs is coming from like these complex chronic disorders. All of these multi-systems, they are not focused on one organ. So you have an entire health system that's very organ focused.
11:15And meanwhile, sick people were falling apart from head to toe and are struck with figuring out how to get out of that. So, you know, I'm really thinking about how AI can help, but also how we can, like, reform the healthcare system to adapt to what people are going to need in the future. Well, I think that's exactly right. I mean, you know, it is two-pronged, really. One is helping individuals understand their own health in a way that was never possible before from their lab data. And Function allows people to do that from imaging. And Function allows you to do that through wearables, which integrate now into Function, through any lab that you've ever had done.
11:52You can upload into Health Vault and get all that information. And also you can access all the scientific literature in the world and all the knowledge expert training and all the genetics and your microbiome and your metabolome and toxin levels and measuring things that we never could measure before. And now we're doing it at radically deflationary prices and at great scale. No individual doctor can make sense of that. But it's going to tell a story about what's going on with you that you might not otherwise think about. And the narrative you said was really important. There's a specialty for every part of your body.
12:25And there's literally a doctor for every inch of you. I mean, it's so subspecialized now. And I think what most doctors miss is the body's one network. And networks are hard to understand. They're complex. I mean, you've got biology, you've got chemistry, you've got physics, but you've got all of it together in the body. And it's just impossibly reductionist about it. And that's what medicine's been. But now with our ability to sort of source the whole world's knowledge, sort of like like a gigantic library of Alexandria in a way, we can suddenly actually have insights about things and learn things.
12:58So not just for individuals, but we can also accelerate science and change the paradigm. And I think that's what's exciting to me. So I think medicine is going to be shifted from the outside, you know, just like many other industries were shifted by, you know, like phones were disrupted by Apple or music by iTunes, you know, Spotify, these are, these didn't come from within the industry. And I think this is what's, what's so exciting to me because, you know, like Like you said, doctors try their best. The healthcare system does it best, but it's sort of stuck in this antiquated model. I really want to hear how you use AI for yourself because you've tried to figure this out as an individual.
13:29Like, what's wrong with me? Why do I feel like this? What are the causes? What do I do? Like, what is my doctor not telling me? How have you used it for yourself? The main thing is exactly what you said. It's connecting all of the data about me in one place so that it can be analyzed. And like the first time it happened and I connected my health records, my Apple health data, all of my, you know, past labs, my medical history, all in one place in ChattGPT and just asked ChattGPT like, hey, are there patterns that you're detecting that would be interesting? I also uploaded my whole genome in there.
14:01I was blown away because I had been, you know, again, I had seen 20 doctors, but not a single one of them had looked at the whole picture and was able to analyze all of this data and give me patterns that you can only detect when you see that full picture. So that has been really helpful in like finding new avenues to explore, getting new ideas, not having to read all of the, you know, studies coming out because like, who has the time? Like I get a summary every morning on like new studies on my condition. I get a summary from like new treatments that people on Reddit are trying out because we spend so much time when we're sick on forums trying to figure it out.
14:40Now chat GPT does that for me. So that has simplified my life in a very big way. And in an even more concrete way to give you a real story. Last year, I was having a kidney stone. I was having surgery and I was hospitalized. I developed an infection and the nurse arrives and she's like, hey, I need to administer an antibiotic for your urine test came back, you know, with an infection. And I was like, hey, like, I'm totally fine with that. But can you wait a minute? I just want to check something. And I put the name of the antibiotic in chat GPT and already had all of my health records. Right. And so it immediately told me, hey, this antibiotic is standard for UTI.
15:22But in your case, it might reactivate a really serious infection that I had had a couple years prior, C. diff. And he said, you really shouldn't use that one. There's a better one to use that will do the job, but without risking messing up with your microbiome. And so I said that to the resident and I was expecting pushback. And in fact, the resident was actually totally relieved because she told me, she's like, I have five minutes to make the rounds. I cannot look at like someone's health records five years ago. And I'm really glad that you picked that up because that could have been really bad.
15:58So I'm glad that I can now give you the right antibiotic. And that made me realize, wow, like again, one of the most important decisions of my life would have been kind of messed up if it wasn't for AI helping connect the dots fundamentally.
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18:04It's such an important story. And you're right, doctors are relieved because like you got five minutes you got 40 patients you're running around like crazy you don't have time to research everything you know even with with ai it's still hard what what did you learn about your health that was novel or new that helped you when you started to put all your records into chadgbt my whole genome was really interesting because um it's not that i had like genes that were like very clearly pathological but because of certain components of genes i was able to, ShadGPT started telling me some potential drugs that doctors hadn't thought about that because of my genome could be interesting and they ended up really helping.
18:45So that was really helpful. It also detected that, you know, I needed like B vitamins that were methylated and like things that doctors hadn't dug into. And, you know, that was really interesting because years ago there was this promise of genetics, like changing the whole medical world. And the reality is that it doesn't happen, right? It does happen in cancer, but like for your day-to-day care for a regular chronic illness, your doctor is not analyzing your whole genome and telling you to change your nutrition based on your genome, right? But all of this data is available and actionable and could help patients really improve.
19:23And so to me, like that combination really helped. And then combining that with Apple Health and really being able to see like, oh, actually, your HRV is way better when you go to bed a little bit earlier. And like you have a better symptom day after you do that. Just correlating all of these data sources was really magical. And that's what we're hoping to do with, you know, chat GPT Health and making sure that you can have all of the right inputs so that your personalized health agent gets to know you better than anyone else and can really do true personalized advice, which was the promise of personalized medicine.
20:01But again, we didn't get there. I think you're right. You know, I think a couple of important points here. One is, according to some recent data, 93 % of your health outcomes and longevity are not determined by your genetics or determined by what we call your exposome, what your genes are exposed to and how they get expressed depending on that. And you mentioned, you know, something quickly, which involves you need a different form of B vitamins. We're not looking for mutations, particularly in your genome. We're looking for variations in your genetics that affect how your body functions. And you need a particular form of B vitamin that bypasses a step that's kind of sluggish.
20:34It's not like a pathology per se, but it's just a little bit of a quirk. And, you know, for example, one third of our DNA codes for enzymes. Enzymes run all the chemical reactions in our body. Every enzyme needs a helper. Each helper is a vitamin or mineral. And so there's a huge variation that nutrient needs in a population never is looked at by doctors that don't even probably know about half of them know about this. I mean, some of them might know about this gene MTHFR that I think you have, but you know, it's not that hard. And now we went from a billion dollar genome when it was first decoded to a$300 genome.
21:09So it's really accessible for almost everybody and only have to do it once in your life. And so now you're right. You can say, hey, what should I be thinking about that I didn't know? And how could I be helped? And I wonder if there were any other things that it suggested to you from a causal perspective or any kind of things that your doctors hadn't suggestion besides like what vitamins to take or what drugs to take yeah i think it was it was mostly like um so the challenge with chronic illness as you know is that you rarely collect one diagnosis when you have one you start collecting a lot of problems which also points to the fact that traditional medicines put labels and conditions but doesn't understand biology and so what was helpful actually have chat gpt tell me like hey yes you have like you know five different diagnoses but fundamentally it's only one thing you have like this dysregulation of the nervous system and these are even some lifestyle you know changes you can make activating the vagus nerve and like things like that that could potentially calm your system down and so again it's like finding pattern across like a variety or constellation of symptoms and diagnostic et cetera, trying to solve them one by one and trying to solve the underlying problem, which has been just really helpful.
22:25Well, it's amazing. I mean, without being a doctor or healthcare person or a tech person or a business person, you sort of stumble upon what is the future of medicine, which is understanding the body as an entire ecosystem that's a network that has root causes, that there's fundamental systems that affect everything. and you know in my first book uh you know over 20 years ago i i had a chapter that was called if you know the name of your disease you don't know what's wrong with you right it's just the name of the disease it doesn't doesn't tell you the why it tells you the what and i think you know saying you have pots is just the name of a syndrome it is just a fancy medical word for saying when you stand up you get dizzy and your heart rate goes up that's what it means in english but it's a fancy word, you know, postural orthostatic, tachycardia syndrome, blah, blah, blah.
23:12And I think, you know, we make all these fancy sounding things when we don't know what we're doing. And the truth is there are root causes. There are reasons this is happening. There is a way to understand how to treat the system. And I think with the advent of AI applied to our personal health data set, which we've never really had the ability to do before, we're going to be able to really accelerate discovery in medicine, and accelerate people relieving all kinds of chronic illnesses. I was able to cure my chronic fatigue syndrome, which most people would say is incurable, just like people say POTS is incurable, but it's not.
23:46And I'll help you if you want to figure it out. So I'm wondering why OpenAI and you, in particular, head of apps, decided to start with health. Was it because of your health condition or was it because of the fact that 230 million people a week ask ChatGPT about their health? Definitely the leading cause was we saw that this behavior was already happening. Like, you know, some of the best stories that I hear about GPT are about, like, you know, helping people with their health. It's 230 million weekly. It's 40 million people daily. It's billions of conversations a week. It's 5 % of total conversations.
24:25So that gives you a sense like of the scale that this is already operating at. So when we saw that, and we hadn't really done anything, you know, super specific for healthcare on the product side, we had done a lot on the model side to answer a question in the right, accurate, factual way. But on the product side, we realized, actually, there is a lot to do to build upon this use case. And if we could get people to connect to their health records in a much easier way, which right now is very hard, if we could get them to connect to Function Health and pull in their data from there, from Apple Health, like now the models are powerful enough that they can extract insights out of this data in a way that no one else can.
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25:10And so that was the impetus behind ChatGPT Health. And my own experience certainly influenced that because I was already really primed to think about how we remove silos and how the defragmentation of information could lead to much better insights. The other thing that was interesting in my mind is like, you know, as you know better than anyone, healthcare is really sick care. it's like you go there when you're sick, whereas really what we need is preventative health. But preventative health, when doctors only have 15 minutes for you, is not going to happen that way. Whereas with chat GPT, you can have literally a health coach in relationship with you every day telling you like, okay, this is how you slept yesterday based on the data on your co-waring.
25:58Today, you should do this kind of exercise. You should eat this kind of food. And then tomorrow will reassess again. And like having that kind of assistant to really help you with your health every day, not just when you're sick, not just when you're seeing the doctor, that's really what gives me hope that we could get to the root of chronic illness because so much of it is lifestyle related. Yeah. And I think you just hit on something super important is that most of medicine is focused on disease and on treating disease. And yes, there is prevention, which is, you know, mammograms and colonoscopies and checking your cholesterol and PSA and getting a bone density.
26:35And that's all important. That's all important. That's how we typically think of prevention in medicine, you know, take your stat and take your aspirin and that's okay. But, but that's, that's not true prevention. That may be early detection. And, and also it's not about creating health. And so what I think for the first time we're really beginning to understand is what is health. I mean, I never got a class in medical school that said, here's how to create health, creating health 101 for doctors, like didn't exist. You know, no clue. If you go to your doctor, say doc, you know, I'm okay. I don't have a disease, but I want to be like really healthy.
27:10Like, what do I do? They go, well, eat better, exercise, get enough sleep. Don't be too stressed. Like it's very platitudinous and not very specific and it's not personalized. But now we're, we're having, you know, precision health, precision nutrition, precision medicine in a way that we've never had before. And it really allows us through depersonalization, which can only be done through something like AI and through understanding the science of health, not just what is the science of disease, but what is the science of health? What is a healthy human? Even defining that, we haven't never defined that.
27:41It's crazy. You know, like you put your car into the computer at the auto shop and it reads a thousand different metrics and tells you what's a little bit off of here. I mean, if your HRV goes down by 10 points one night, it's not a disease, but it's giving you a clue that you're not exactly where you should be, right? So that's what's so exciting to me is we're going to be able to help people understand not just to treat disease or prevent disease, but how do we actually create health? And that's where this becomes really, really exciting for me. I'm wondering how you see Chatshubi Health working along partners like Function and collaborating and integrating with them.
28:18Well, I think partners are absolutely critical because the whole point, as I was saying, was like having one place where all of these different parts of your health can be connected into so that we can see the full picture. And right now, you know, we like rely on partners to be able to do that because everyone has kind of a different lens. Like you go to Apple Health and you're going to get a lot of the, you know, lifestyle data. You go to function and you're going to get a lot of like the biomarkers. Health records are going to tell you a different story. So to me, it's really about like Like, how can we partner with as many players as possible so that the end user has a full picture of their health across many different sensors, many different biomarkers?
29:01And that way we can do the best job possible at helping them personalize everything for, you know, their lifestyle. So that's super important for us. And then there's also a type of partner that's more about being able to take action. You know, we're in partnership with Instacart and I was the CEO of Instacart before coming to OpenAI. And that's a good example of like, you know, nutrition is so much at the heart of health. You know, it's funny that I'm telling you that you're the utmost expert at it. But it's really hard for people to take action on nutrition advice. Usually, even if you go to a nutritionist, which very few people have the resources to do, you end up with like a piece of paper, you put it in the drawer, you never look at it again.
29:47And what one is like, can we make it actionable? So with a partner like Instacart, you can go from, okay, this is what you should be eating to like in one tap, order that and it's at your door in an hour. And like, that's a magical closing of the loop where you really start with to your point, what is else and how do we help you get there? And then all the way to actions that you can take in like as easy a way as possible to be able to stick to this new routine. I think that's so important. You know, like you're right. I mean, in getting people all the way down the pathway, not just understanding what's going on, it's just having an assessment of what their disturbances are in their health or simple things they can do.
30:26But how do you take it into action and how do you kind of close the loop? And, you know, I know Instacart is working on medically tailored meals, for example, and, you know, food is medicine initiatives, which is amazing. Right. But most people wouldn't know how to do that. I mean, we can tell through Function Health you have diabetes, but then it would say, you know, we want you to eat a diet that's low glycemic, higher and good quality fats, lots of fiber, good quality protein. And then what? Like, then they will turn that into a menu plan for a week and then go to Instacart and go shopping for me and deliver it to my door and show me the recipes on how to make them by video.
31:04And like, all that's coming really soon or if it's not already possible. The Instacart app in ChatGPT already allows you to do that. it's really magical like you can literally just say i have a family of three these are health condition develop a menu plan for us and then buy all the ingredients in one tap and to me like that was always my dream of removing friction as much as possible so that being healthy isn't also overwhelming it just feels easy and and i think we finally have the tools to get there yeah it's pretty exciting i'm like thrilled about it and i think that that the food is medicine part is important.
31:39You know, you grew up in a little village in France. You said you need a passport to get to the next village because it was so remote and isolated. And it's this little fishing village in the South of France. And food is such a part of French culture. And, you know, the freshness of it, the realness of it, the deliciousness of it. It's not just a convenience. It's also centered around connection and family and friends and social connections and, you know, all this shifting as people start to understand the relationships between their health and food. And, you know, I mean, you know, when you go to the doctor, they don't tell you to do anything about nutrition.
32:19You know, I've been trying to work on changing medical education by getting nutrition exams, questions that have a nutrition focus that's based on chronic disease. And yeah, so doctors are really challenged and this makes it easy. Less than 20 hours of medical school spent on nutrition, which is crazy when you realize that, like, I think something like 80 % of chronic illness as a diet component. It's like, it was crazy. So, yeah, I totally agree. And yes, growing up in France, you know, food was sacred. Like, it was at the center of everything. And here I think it's more considered like sustenance, right?
32:57and uh and i think re-establishing the relationship that people are with food is really important you know function week we kind of help you sort through the massive mess of data i think the function app within that's integrated into chat gpt will help people understand their data in a broad level and help guide them on action plans i've been playing with it it's pretty amazing uh and integrating that with like all the tools to be able to kind of execute on the recommendations whether it's what supplement to buy or what food to eat or what what things going to help you what drug could help you it's it's going to be pretty profound it's a really important advance and it hadn't existed before and i'm really glad to see you started there because it is like you said something people are using every day i mean people are i don't google a billion searches on health every day and and and now chad gpt in some ways is replacing google i don't i don't know if i last time i used google honestly so i hate to admit that because my friend is one of the founders to that but um it's it's it's a it's a really exciting moment i'm very curious to hear your vision of uh if you had a crystal ball where you see you know this movement between ai and health intersection going in like one year three years five years because even in the couple of years that we've had chat gpt and ai that's accessible as a consumer facing product which i learned was not even meant to really succeed at all it just took off you know as an accident it was kind of like a side thing where do you see you know this going because it's just even in the few years that it's been happening it's accelerated so fast and i and i wonder from the perspective of health care from individual self-care from research like what are the areas you see us us being able to really accelerate human evolution we've talked a lot about like what's going to happen on the consumer side and i think ultimately it's really about empowerment we're going to empower people with health information they're going to be able to make better decisions about their health and just have a lot more data to optimize their health.
34:55So I think this is going to be reflected directly into health outcomes. We haven't talked as much about the provider side, but we're also really invested here. We just launched OpenAI for Healthcare with a ton of great institutions like UCSF, Post-On Children, Sends for Children, HCA, where these institutions are deploying chat GPT world to all for their doctors to be able to assist them in clinical decision making, to be able to reduce administrative load. And so we're really thinking of it as like equipping both sides so that doctors can be more informed because to your point, they cannot read the thousands of studies that come out every week.
35:36They can be more informed. They can make better decisions because they can look at the full picture of the patient. And then when they meet with the patient, the patient is also better informed about their health, and that creates a much better dialogue between a doctor and patient. So that's really the end state. And then beyond that, I think the thing that gets me very excited is that I think we're finally getting at a level of intelligence of our models that can really find novel insights and novel science. So when I look at, you know, all of the diseases that have not yet been cured, I hate calling them incurable, because I believe that it's just a matter of time.
36:14I really think that the models are getting smart enough. That's the timeframe from kind of identifying a condition all the way to having a drug ready for it. All of these steps are going to be reduced by AI. We're going to identify drug targets way faster. We're going to develop these drugs way faster. We're going to get them through regulatory approval, which, as you know, takes forever right now, much faster. And by using AI at every level. And so that's why, you know, I think when a couple of years ago we were talking about curing all diseases in our lifetimes, that sounded a little bit like science fiction.
36:49I actually think that we're closer than ever, as long as we can, you know, update all of our pretty outdated processes and regulatory framework to this new world that would allow us to massively accelerate the pace at which scientific discovery happens. I think you're so right about that. I think it's going to accelerate the development of drugs and of discovery in so many ways. But I also think it's going to do something else. And I don't know if you've thought about this, but I'm hoping you have, because your company, Chronicle Bio, which is related to help people solve these, quote, incurable diseases like chronic fatigue and Pott syndrome and many, many other conditions that are chronic and often intractable.
37:36I think what's going to happen is going to be acceleration of medical understanding, not just about how to develop better drugs, but about root causes, about mechanisms, about novel therapeutics that involve food as medicine, that involve other therapies that are kind of outside traditional medicine that could accelerate healing, that are being applied across different things like, you know, novel therapies, for example, like plasmapheresis that's being used for autoimmunity, that's being used for long COVID, that's, you know, that is still sort of on the margins as part of traditional medicine.
38:06but it hasn't been used for that. So there's a lot of things that I think are going to happen that are both accelerating the way we do medicine already faster and better, which is important, but also to kind of emerge a new paradigm of medicine where we can actually understand the body's a network, where even if you get better at each specialty, the body still isn't organized like a bunch of parts. It's a system. And that's what's so exciting to me about the use of this technology and AI to help understand these massive data sets, look at patterns, discover things that never were seen before, understand this.
38:41And I know that's doing this for 30 years. Like I collect massive data sets on people compared to the average doctor. I mean, I look at everything you possibly think of looking at. And I sort that through my own little brain here, which can only hold so much. But I know I've seen patterns in the data that nobody's ever described before. For example, I know when someone comes in, they have a heavy metal toxicity. First of all, most doctors don't look for it. but when they do i i see they have methylation problems they have low glutathione they have low zinc they have lots of oxidative stress they have low amino acids they have a whole series of patterns that that i've never seen written up in a book or a paper before and i'm like oh this is interesting you know and i and i you know i see this with autistic kids too there's all these genetic variables and all these different metabolic changes and they're not being described widely because doctors aren't looking for them and and there's a there's a joke i often tell and I'm giving lectures about this guy who drops his keys on the street.
39:37His friend comes by and he sees him looking under this lamppost. And he's like, what are you doing? He's like, I'm looking for my keys. He said, well, where did you lose them? He said, well, I lost them down the street. He said, well, why are you looking over here? He says, well, the light's better over here. So we tend to look where we can find things easily, but not where the problem is. And I think the root cause approach to medicine, the systems approach, people like Leroy Hood, who's doing the Phenome Health Project, they're thinking like this. They're thinking about this new paradigm. And I think that's where there's going to be a whole acceleration because, yes, we want to do all things to get better drugs and better discovery and so forth.
40:11But I think the biggest flip is going to be really changing the actual medicine we're doing and helping people create health and dealing with these chronic conditions that are, quote, incurable. In fact, it's funny you said that because I'm launching a new feature on my podcast called The Incurables. And it's for people like you who've been through the healthcare system, who've tried everything, who've done everything. And who were told there's nothing to do except take this drug and maybe it'll help your symptoms, but you're going to have to live with it forever. And the truth is you don't. If you understand how to solve the puzzle, you can actually help people get better.
40:42And that's the beauty of this. I think the problem we have, right, is that because we don't have the data, we are not able to sub-segment like the people with these conditions so that we can find the exact thing that works for them. You mentioned my company, Chronicle Bio. Like that was the impetus behind it. we realize we're not going to find cures for long COVID overall because long COVID is probably 20 biological processes under that or a cure for blood. And so what we decided to do was actually create the company that partners with clinics to get biological data from patients and analyze everything on the samples, genetics, multiomics, proteome, metabolome, etc.
41:23so that we can actually sub-segment those populations. And I think that's really the promise of big data plus AI that's going to allow us to find those sub-segments of population and be able to do better by them. I'll tell you a story. At some point throughout my journey of trying to fix the problem, I opened up a clinic for these conditions, and we were running clinical trials, and we were running a particular drug for long COVID, And we had people that went from completely bedridden to completely functional. But the clinical trial failed in absolute. And the reason is there wasn't enough segmentation of the patients to realize, okay, on those, it's going to be miraculous.
42:09And on all of those, it's not going to work. And so they killed the program. And now we had patients in tears saying, this drug would save my life and it's not available. And to me, that's the greatest strategy. So if we can have the right data, so we identify the right population of patients, the right treatments for them, and then that can accelerate clinical trial approvals for these subconditions, I think that's the holy grail and that's where AI is going to really shine. A hundred percent. That's why I said earlier about in my first book where I said, you know, just because you know the name of your disease, it doesn't mean you know what's wrong with you.
42:42It's just a label. And that label could represent 10 or 15 different problems. And, you know, autism isn't one thing. Alzheimer's isn't one thing. You know, POTS isn't one thing. Chronic fatigue isn't one thing. It could be caused by Lyme disease or by mold toxicity or by mercury or by some type of microbiome issue or by some other weird infection that you don't know of or long COVID and all these things, but you have to be able to figure that out. And given our current way of seeing things and thinking about things, we have a thinking problem in medicine. And that's really where we're going to be able to think differently with the use of these tools in a way that we never did before.
43:21And it's not going to come, I don't think it's going to come from inside healthcare. I think it's going to come from outside healthcare. And basically companies like OpenAI are going to be driving change from the outside in. And companies like Function are going to be driving change from the outside in where we're, I mean, think about it, like where, where could you get massive data sets on your human biology before without spending a fortune, without having to go through your insurance company, like function has unlocked that. There's just, people are desperate because they're not getting the answers from the healthcare system.
43:50I'm very excited about this for, for individual empowerment. And we say, you know, our goal is to help you be the CEO of your own health, right? We, we also say, you know, we want people to help people live a hundred healthy years. I would also add to that. We want people to feel a hundred percent because, you know, living 100 healthy years is great, but if you feel crappy now, like, you know, we want people to get there faster. And also, like, I just think this is a moment in time where access is going to change dramatically. I mean, function is a way to give access at a low price point to things that were reserved for the elite before.
44:23ChatGPT does something similar of giving you access to great medical information. And one thing that was striking for me that seven out of 10 of the queries, health queries in chat GPT are actually happening after hours. And so that tells you, you know, like there is demand to have answers about your health at times where the healthcare system isn't even available to you at all. We are also seeing a lot of demand in rural areas where, you know, the hospital, like many miles out. And so there is like this, you know, direct access to health information that I think is going to really democratize just, you know, health knowledge in general.
45:03I think you're right. And I think, you know, as we understand the science of creating health, you know, we're going to be able to help people even without health care, because most of health doesn't happen in the doctor's office. And so we will guide people in ways where we can make it much more accessible, affordable. And I'm thinking about function in a way that is going to help people all around the world by the things that it learns. and if you're in serial loan somewhere and you have some condition, you're going to benefit from all the insights so that somebody who maybe can't get a lab test, we can infer what's going on from the patterns and the data that they're sharing.
45:37And it's kind of an exciting thing because all of a sudden it's going to democratize healthcare, decentralize healthcare, make it really affordable or often free for people. And I think there's a free version of ChatGPT, right? Absolutely. Is there? Yeah. Yeah. Okay. So that's what I'm imagining. And people will be able to query their data and learn from the world's sort of best knowledge sources and insights from the best doctors. And Chad GPT Health, which we've been talking about, is available in the free tier. So the goal is really to make it as accessible to everyone as possible. Oh, that's amazing.
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48:35I want to ask you how I get off the wait list.
48:41I click. I want to get on the wait list. I want to try it more. But I tried the integration with Function, which is very cool. And I was like, well, this is amazing. And it gives you a lot of deep insights. And I want to ask you a little bit more about Chronicle Bio, because this is a passion project. It's not like, you know, you're not busy. You're at OpenAI. You, you know, CEO of Instacart. You're on the, you know, chairman of the board of Instacart. You were at Facebook for a decade. You, you know, had another nonprofit or something company. You have, you know, now you start another company.
49:10Like, I don't know what you do. How do you do if you sleep? I know you have a daughter and a family. I know why you started it. Tell us more about how you're thinking about it. And you mentioned a little bit about the data sets you're collecting, but who's guiding you? How are you thinking about these conditions? And what are you hoping to kind of discover? I think for me, it was really seeing this moment in time where the models were becoming so much more powerful, but the data sets weren't fully there yet, right? Like on these conditions like long COVID, MECF, which are still considered somewhat mysterious.
49:46If you look at what has been done, a lot of studies are like with 100 patients and maybe just looking at genetics, another 60 patients somewhere else looking at, you know, maybe gut microbiome. But no one was creating what I call almost the infrastructure of the disease, which is really like looking at tens of thousands of clients and really having the full data set on all of them. And that's, you know, that's because that requires some funding and that requires infrastructure, partnering with all the clinics, making sure they collect data consistently. I mean, it's a real engine that we're building.
50:22But once we have that, we're going to be able to get to cure so much faster. Because when I got sick, I went and I talked to a lot of my biotech and pharma CEO friends because I was telling them, like, it's not as if these conditions I have are rare. Like, we're talking hundreds of millions of patients all combined. And so I was like, it's a huge market. Why are you not developing, like, cures for these conditions? And, I mean, we don't even have any cures in the pipeline. Like, you know, they're not being, like, really prioritized. And the answer was simple. It's like the CEOs were saying, we don't understand these diseases.
51:00We don't understand the different subtypes. We don't understand biologically how they function. So it's still too risky for us to invest in these conditions until someone has really established what are the subgroups, how do these diseases work, what are the real drug targets. And so I think we're really at the moment where if, thanks to Chronicle Bio, we get all of this data combined with all of the great models coming out of OpenAI and labs like that, we're going to be able to all of a sudden find totally novel insights. And we're already seeing it. You know, we had some publications around findings, like tens of genes that correlate with your likelihood of developing these conditions, which in the past you couldn't really do.
51:45You could do just kind of one gene directly responsible, but gene combinations was still very complicated to establish. Now we can figure that out. We are planning on overlaying that with like why viruses are a big trigger for these conditions. What happens to your immune system during these moments that lead to you not recovering? Also, why are these conditions affecting 80 percent, like 80 percent of patients are women and only 20 percent are men? We should have an answer to that. That seems pretty extreme. Like we should know why women are more affected. And the reality is that we don't have answers to this question because, again, the healthcare system has looked at the symptoms and putting Band-Aid on the symptoms instead of the root biology.
52:30And I think the only way is to do the hard work of collecting that data, that true biological data, and then using AI to find novel insights on top of it. I think you're right. And I think, you know, that's going to accelerate discovery. not just around those things, but even things like autoimmune diseases and even chronic diseases in general, because they're all sort of the same. And, you know, there aren't that many causes for disease. There's many diseases and each disease may have multiple causes and need multiple treatments. And I think, you know, the promise of network medicine is understanding the multi-causal nature of disease and the need for multimodal treatments, meaning it's not just one thing.
53:11It's not like a single drug for a single disease. you know like we learned with louis pasteur and the bacteria that cause pneumonia that treat with penicillin we've followed that paradigm for the last hundred plus years and it's great for infectious disease sometimes not always so it's not just the bacteria or the virus it's the host that matters too uh and and actually it was claude bernard another frenchman who uh who had an argument with pasteur saying it's the biological terrain that matters not the bacteria not the pathogen and pasteur on his deathbed goes yeah i think you're kind of right you know so i think the biological brain matters a lot and i think when i said what is what is health uh it's really about understanding how to create a healthy soil you know traditional medicines like industrial agriculture we pour chemicals on the plants and the soil to try to make it do stuff uh which is like using pharma which can be helpful but it's it's rather than asking how do we create a healthy soil where disease can't grow and and how do you create health and when you do that disease often goes away as a side effect when you remove the impediments to health and you add in the ingredients for health the body often knows what to do to repair and that's that's a lot of i think where the solutions are going to be coming from that you're looking for is is not just one thing or one drug or one pathway but really understand the complexity which only can be done through big data and ai and understanding things through this new lens and you know if i were to say to you like what are the laws of biology you know you might say well maybe evolution but there wouldn't be a set of laws that you could say here's the laws of human biology and human disease we don't have that we have that for physics you could say i know the laws of physics thermodynamics and gravity and this and that the other thing um i mean i learned that you know in uh in uh college i forget a lot but i know they exist uh but biology we haven't actually described them it mean they're not there you know what's the nature of nature that's really the question we're asking and and we're going to unlock that now with ai and in in systems network functional medicine whatever you want to call it that's what we've done it's really tried to understand what are the fundamental systems in the body that can explain everything and you know we talked about the microbiome the immune system the mitochondria energy system the detoxification system your circulatory transport system your communication system which is hormones neurotransmitters peptides cytokines everything and your structural system and how those are influenced by external factors you know genetics and toxins and allergens and microbes and microbiome and stress and diet and then all the things you need to thrive you know the right food and nutrients like you said you need special forms of nutrients for you fiji that somebody else doesn't necessarily need you know what's the right amount of exercise and sleep and and in light and clean water and connection and love and meaning purpose these are all the ingredients for health so when we understand this paradigm, we have the equations, so to speak, the laws of nature on how to solve this.
56:07I mean, the French actually were pretty good. Like Pierre Laplace, another French guy, he also said the same thing. He said, you know, we can explain an enormous number of observable phenomena by a small number of general laws. And we have 155 ,000 diseases in our ICD-10 classification of disease system that we have in medicine. It's crazy. Like we don't have 155 ,000 know, 155 ,000 diseases, we have a few simple laws that explain all of them, right? And inflammation is a big thing. The microbiome is a big thing. You know, the role of toxins is a big thing. The role of microbes is a big thing.
56:41So we can start to understand things through a new set of lenses and see different things. Like when you, you know, like I was at this party this weekend in South Africa at a wedding and they had astronomers and they had this incredible telescope that looked at the Orion Nebula and it was like taking this pictures every like four seconds or something. And I was like, you get to see stuff where I can see Jupiter and the rings on Jupiter and the moon. So all of a sudden, you, you know, you look with a certain set of lenses, you can only see certain things. You look with another set of lenses, you can see something else.
57:09So what's happening now with technology and AI and what you're doing with chat, GBD health and function is, is actually going to put on different set of lenses and see what we need to see. And Chronicle Bio, I'd love to offline talk to you more about this because I have a lot of thoughts about it. And I think, It could be really interesting to have a conversation at some point. And I can so relate to what you're saying. For example, in my case, I have both endometriosis, which is considered a reproductive health problem. It's also autoimmune. Neurological. But apparently, you're seven times more likely to develop endometriosis when you have POTS and vice versa.
57:45And so in the medical, current medical language, these are two totally different diseases. You look at the statistics, it's like, clearly there's a correlation. That's probably inflammation. That's probably immune-related. But we haven't gotten to this level of understanding. So that's the thing that I think is going to be really magical in the next year. It's getting to those root causes. That's what I spend my whole life doing. So as we sort of think about what's important to get right, and as we're thinking about the intersection of health and technology and how people live their lives going forward, what is what keeps you up at night?
58:18What are the things we have to get right as we go forward in this new era of health and technology? First off, you touched on it, but trust is really important. If users develop trust in the technology and know that the technology has their back and is helping them lead a better life, I think that's already a big part of the problem. And that's why we focus so much on privacy, encryption, all of the things that we put in place. Because if you don't have that at the start and users don't trust that technology is going to do what's the right thing for them, you can't do anything else. So I think it's like step number one.
58:56And then from there, it's like, how do you add utility? And I think the advantage of a tool like ChatGPT that's so general is that it helps you with every part of your life. So you naturally reach for it when you have a health question. A lot of people don't think of it as a health tool. They just think of it as an assistant. And then they ask the health question and they realize, oh, wow, that's like really helpful. I'm going to put a lot of my health information there so that I can get more out of it. And so really like demonstrating utility, both for patients and for doctors is going to be really important.
59:28And then I also think, you know, there is a like general perception which we need to address. I think AI is going to be incredibly helpful for doctors. And you see some doctors really embracing AI in a big way. You also see some resistance and some tension being like, oof, is that going to get in the way of the doctor-patient relationship, et cetera. And so if we can really show the healthcare system what they have to gain from being ahead on embracing technology and having that as a big differentiator to improve patient care and also to improve burnout for doctors, because we shouldn't forget that there's a massive burnout epidemic of doctors.
1:00:11And if we can give them the tools so they can give even better patient care with less burnout, less administrative burden, we're going to lift the entire system up. So my hope is actually that people on all sides embrace technology as an ally and that the responsibility is on us, technology builder, to build it in a way that is responsible to really address their needs. It's going to solve a lot of problems. The physician burnout thing is real. I mean, I know I do a different kind of medicine and it takes me two or three hours to properly prepare the data from a medical history, from their previous results, from their lab data, and organize it so that I can be ready to look at it, to make a decision about it.
1:00:55And then I can think about it and I can use my license and my 40 years of medical training and experience to actually think as opposed to be just organizing like a paper pusher. And it's, it's kind of, it's made my life so much easier as a practicing physician, which, which, which is, it's just so easy. And I think it allows, it's going to allow better patient care, better connection, more stream-like efficiency. But, but more importantly, I think it's going to, it's going to shift the paradigm to where we're really going to, you know, unlock a lot of understanding of human biology and, and, and so much suffering for people like you and for people like me who had to deal with stuff that didn't have answers.
1:01:33You know, I've, I've had so many things i even had c diff like you which was no fun yeah no it's no fun so going forward a year from now where do you hope uh chat gpt health will be i think uh we will likely be even more of a connector between all of the different aspects of your health and be able to help you take action on your health even uh in a more easy way i'm very excited to have chat gpt health also become proactive. So like right now you go to chat GPT, you have to be the one kind of typing a question and getting an answer. I think once we have all of this knowledge about you, we can proactively tell you every morning, like, Hey, this is what you should do to optimize your health.
1:02:17And that level of proactivity, I think will really enlighten a lot of people who want to like do more for their health, but don't know where to start. So having that as a proactive agents that has your back, that knows everything about all of the aspects of your health and help you take action in the real world will be very helpful. And then if the same happens on the kind of healthcare side, you can imagine these tools really coming together and like the future appointment between a patient and a doctor being both more efficient, but also much more focused on the right issues because everyone will have been briefed ahead of time, have the right data and the conversation can really focus on how to make that person better instead of a doctor staring at the screen, typing away administrative stuff for the, you know, 14 out of 15 minutes with a patient.
1:03:06So we really hope that it can really help improve that relationship as well. So it sounds like three big areas, you know, let's say health consumer or patient empowerment around their own health information data, helping streamline healthcare itself and how healthcare providers interact with people, and accelerating research. And I think there's one area I think that it's worth doubling down on, which is individual empowerment and how that requires your own personal health data set. You know, I've had the rare privilege of working in environments where I could collect large data sets on everybody.
1:03:42I could do their whole genome sequence. I could do their microbiome. I could do their toxin levels. I could do all the hormones and nutrition, all the stuff I said, and spend three hours with them and talk about it all and understand it all. that's still sort of rare for people but now with with function we're able to to begin to help you collect your own data set because the the the output of uh chachi p health is only going to be as good as the data it has on you as an individual like you you fiji put in all your stuff from everywhere into chachi pd right but but it was hard to get all that information and the health care system, you know, isn't so great at helping you figure these things out.
1:04:23Like, why do you want to do this test? Like, you know, like, why do you want to do that test? Or the insurance isn't going to pay for this or, but imagine if the individual now can bypass that and collect their own data sets from everywhere, from their wearables, from omics, from their microbiome, from lab data, from imaging, from their medical records, and all that goes into the system, then it becomes so much more valuable. And that's why I love the integration with Function Health and chat GPT health, because it's unlocking something that was never before possible in human history. Yeah, I totally agree.
1:04:56And I agree with the better the sources of information, the better the advice we're going to be able to give. I totally agree with your point on tests. One of the recommendations from chat GPT was actually looking at my health records and saying, hey, you're still missing these two or three tests that would paint a complete picture. and I asked my doctor and she was like, oh, yeah, actually we should order that. And so I think having that complete picture is going to be super important. And any companies that can help us, you know, aggregate that will be very helpful. Well, I'm excited, excited for this and excited for our integration and working together and thinking about how to really end all the suffering that people are struggling with.
1:05:37That honestly, given our knowledge that we have in the world now around how to create health, most people don't have to suffer from that. And that's kind of my mission in life is end needless suffering for billions of people. I share the hope. Yeah, I think you do. Obviously, with Chronicle Bio, it's clearly something you're not just talking about. You're doing, in addition to the work you're doing at OpenAI, I just hope you take care of yourself and make sure you stay in good health because we need you. Thanks, Mark. I will. Thank you so much for having me. This was great. My pleasure. Maybe one day we can have octopus pie in your town of Sete in France.
1:06:13I can tell you if everyone was eating everything from my hometown, health outcomes would be fantastic. That's true. That's true. Well, thank you so much and thank you for the work you do. And we'll see you soon. Thank you for having me. Bye. What if the greatest threat to your health wasn't bad choices, but bad design? In America, chronic disease isn't accidental. It's the predictable outcome of a food system built for profit, not people. A web of corporations, lobbyists, and policymakers all feeding off your plate. They call it choice, but your options were engineered. From the grocery aisle to the school cafeteria, Big Food, Big Ag, and Big Pharma wrote the rules together.
1:06:59The food pyramid distorted. The science bought. The front of package health labels designed to deceive. This isn't a broken system. It's a perfectly functioning machine. Producing disease, dependency, and distraction. Exactly as intended. Food Fix Uncensored pulls back the curtain on the collusion shaping your health, your choices, and your future. Because once you see how it works, you can never unsee it. Food Fix Uncensored. The truth they never meant for you to read.
1:07:34If you love this podcast, please share it with someone else you think would also enjoy it. You can find me on all social media channels at Dr. Mark Hyman. Please reach out. I'd love to hear your comments and questions. Don't forget to rate, review, and subscribe to The Dr. Hyman Show wherever you get your podcasts. And don't forget to check out my YouTube channel at Dr. Mark Hyman for video versions of this podcast and more. Thank you so much again for tuning in. We'll see you next time on The Dr. Hyman Show. This podcast is separate from my clinical practice at the Ultra Wellness Center, my I work at Cleveland Clinic and Function Health, where I am Chief Medical Officer.
1:08:05This podcast represents my opinions and my guests' opinions. Neither myself nor the podcast endorses the views or statements of my guests. This podcast is for educational purposes only and is not a substitute for professional care by a doctor or other qualified medical professional. This podcast is provided with the understanding that it does not constitute medical or other professional advice or services. If you're looking for help in your journey, please seek out a qualified medical practitioner. And if you're looking for a functional medicine practitioner, visit my clinic, the Ultra Wellness Center at ultrawellnesscenter.com and request to become a patient.
1:08:37It's important to have someone in your corner who is a trained, licensed healthcare practitioner and can help you make changes, especially when it comes to your health. This podcast is free as part of my mission to bring practical ways of improving health to the public. So I'd like to express gratitude to sponsors that made today's podcast possible. Thanks so much again for listening.
From the publisher
Too often, we focus on treating symptoms without fully understanding the systems underneath them—or the conditions that allow the body to function well in the first place.
On this episode of The Dr. Hyman Show, I sit down with Fidji Simo, CEO of Applications at OpenAI, to explore how AI could help us shift medicine from treating symptoms to restoring systems. We talk about why chronic illness is so often misunderstood, how health data has been fragmented across silos, and what becomes possible when we finally see the full picture. Watch the full conversation on YouTube or listen wherever you get your podcasts.
In this episode, you’ll learn:
• Why having a diagnosis doesn’t always explain what’s actually driving your symptoms
• How connecting your labs, lifestyle data, and health history can reveal patterns you might otherwise miss
• What it looks like to move from reactive care to proactive, personalized health
• How better context can help you make clearer decisions about food, sleep, movement, and recovery
Health isn’t built in a doctor’s office. When you create the right environment, the body often knows what to do—and understanding your own biology is one of the most powerful steps you can take toward creating health, not just reacting to disease.
View Show Notes From This Episode
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(0:00) Introduction
(1:27) Dr. Hyman on the revolutionary potential of ChatGPT Health and the complexity of the body
(3:29) Fidji Simo's health journey, challenges in chronic illness, and health system shortcomings
(7:42) The role of AI in health care: Empowerment, personalized medicine, and practical applications
(20:24) OpenAI's focus on health applications and preventative health with CHATGPT
(23:16) True prevention, creating health, and nutrition action through partnerships
(29:08) Cultural differences in food, health, and empowering consumers with AI
(33:44) AI's role in drug discovery, curing diseases, and democratizing health information
(43:12) Chronicle Bio's mission and impact
(52:27) Challenges and opportunities at the intersection of health and technology
(56:07) Future goals and three key areas of impact for ChatGPT Health
(1:00:52) Food system design and its impact on health
(1:02:00) Closing remarks
