In short
The episode argues that brain health depends on whole-body inputs and “functional medicine” (remove stressors/toxins and add nutrients, sleep, light, exercise, connection, and purpose). It claims diet—especially reducing sugar/ultra-processed foods and increasing colorful plants, fiber, omega-3 fats, and adequate protein—can reverse or improve conditions like Alzheimer’s, autism, ADD, depression, bipolar disorder, and schizophrenia. It also emphasizes happiness as a brain function and proposes “brain type”–specific strategies, plus supplements (e.g., omega-3, vitamin D, magnesium, B vitamins; saffron; rhodiola; 5-HTP; GABA/theanine) and “senolytic” approaches targeting senescent “zombie cells” (quercetin/fisetin; plus liver support).
Guests
No guest is named in the transcript (Dr. Mark Hyman speaks; references Christopher Palmer and Justin Bieber).
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VOThe Connection Between Body and Brain
0:45 to 2:19
Discusses how the health of the body directly influences brain function.
“You can also explore my curated doctor-trusted supplements and health products at drhyman.com.”
Personal Journey and Functional Medicine
2:19 to 3:56
Dr. Hyman shares his personal experience with chronic fatigue and the role of functional medicine in recovery.
“I've seen people reverse Alzheimer's, reverse autism, reverse ADD, reverse depression, things that bipolar disease, schizophrenia.”
Nutritional Factors Affecting Brain Health
3:56 to 6:12
Explains how diet, nutrient deficiencies, and toxins can damage the brain.
“my mitochondria, my gut, my immune system, everything that was going wrong, I was able to reverse my chronic fatigue syndrome and my brain got better.”
Eating Real Food for Optimal Brain Function
6:12 to 7:39
Stresses the importance of consuming whole, unprocessed foods for brain health.
“All these things are necessary for our brain to function properly.”
The Role of Fiber and Gut Health
7:39 to 9:09
Describes how fiber and gut microbiome health are crucial for brain function.
“And some things that seem like real food are really not, like yogurt.”
Importance of Healthy Fats and Proteins
9:09 to 10:40
Discusses the necessity of healthy fats and adequate protein for brain health.
“And by the way, your gut and your brain are connected.”
Supplements for Brain Health
10:40 to 11:29
Highlights key supplements that support brain function and overall health.
“a protein shake in the morning, nut butters, fish for breakfast.”
Preventing Mental Health Issues
11:29 to 11:48
Explores the relationship between brain health and preventing various diseases.
“So you need to design a plan for your life that includes your overall health, but you ought to incorporate some of these important practices for your brain.”
Happiness and Brain Function
11:48 to 13:20
Examines the link between brain health and overall happiness, citing research findings.
“And a lot of people wake up with negativity and sadness because that's been planted in our brain through evolution.”
Understanding the Brain-Mind Connection
13:20 to 16:51
Discusses the critical relationship between brain health and mental well-being.
“and we gave them the Oxford happiness questionnaire.”
Show all 25 chapters
The Importance of Brain Types for Happiness
16:51 to 20:58
Discover how different brain types affect personal happiness and mental health.
“So the second one is happiness is geared to your brain type.”
Nutritional Supplements for Brain Health
20:58 to 23:42
Explore how supplements can support brain function and enhance mood.
“And if you're nutrient deficient, especially serotonin, you know, most people don't know that birth control pills deplete serotonin.”
The Four Circles of Happiness
23:42 to 28:00
Understand the four key aspects that contribute to happiness and mental health.
“Let's do meditation, diaphragmatic breathing.”
The Importance of Purpose for Happiness
28:00 to 29:06
Learn why defining values and goals is vital for happiness and health.
“And I have to tell you, Mark, nine out of 10 patients, when I ask them what their goals are and why they think they're on the planet, they haven't thought about it.”
Lifestyle and Brain Health
29:06 to 30:11
Discover the connection between lifestyle choices and brain health statistics.
“grown up so much in the last couple of years.”
Understanding Mitochondrial Function
30:11 to 31:07
Explore the role of mitochondria in brain health and energy production.
“So learning how to grow a new brain, pretty important topic.”
The Role of Senescent Cells
31:07 to 35:34
Learn about zombie cells and their effects on aging and health.
“And whoever runs the death clock runs the show.”
Therapies for Eliminating Zombie Cells
35:34 to 38:14
Discuss therapies to kill senescent cells and improve health.
“Well, we don't know exactly, at least I don't know how they work, but they seem to switch back on the kill switch in mitochondria.”
Harnessing the Placebo Effect
38:14 to 41:27
Understand the power of the placebo effect and its implications for healing.
“it's so fascinating is that, you know, we can start to embed these practices into our daily life.”
The Future of Human Longevity
41:27 to 42:01
Explore unique insights into human longevity and the need for proactive health.
“We're only going to be here to clean the machines.”
The Uniqueness of Human Longevity
42:01 to 42:38
Explore the unique aspects of human longevity compared to other species.
“And only three of those don't have a death program in their DNA.”
Psychedelics and Brain Health
42:39 to 43:58
Discuss the impact of psychedelics on brain structure and function.
“that the brain produces to awaken the higher brain.”
Integrating Sacred Practices with Psychedelics
43:59 to 45:20
Understand the importance of sacred practices in psychedelic use.
“If you've seen the brain on drugs, on psychedelics, you find that there are 20 to 30 times the amount of neural networks.”
The Future of Human Evolution and Healing
45:21 to 46:27
Learn about potential future changes in human evolution and health.
“And I think it's going to change everything.”
Generational Trauma and Resilience
46:28 to 48:18
Discuss how trauma and resilience can be passed through generations.
“And that gets programmed generationally.”
Transcript
Automatic transcript. May contain errors.0:00Dr. Mark Hyman:Coming up on this episode of the Dr. Hyman Show. So fixing your brain starts with fixing your body and optimizing all the inputs into your system and minimizing the bad stuff, the bad inputs, whether it's stress, poor diet, toxins, allergens, bad bugs, drugs like caffeine, alcohol, sugar, whatever's causing your brain to not work. Before we jump into today's episode, I want to share a few ways you can go deeper on your health journey. While I wish I could work with everyone one-on-one, there just isn't enough time in the day, so I've built several tools to help you take control of your health.
0:32Dr. Mark Hyman:If you're looking for guidance, education, and community, check out my private membership, The Hyman Hive, for live Q &As, exclusive content, and direct connection. For real-time lab testing and personalized insights into your biology, visit Function Health. You can also explore my curated doctor-trusted supplements and health products at drhyman.com. And if you prefer to listen without any breaks, don't forget you can enjoy every episode of this podcast ad-free with Hyman Plus. Just open Apple Podcasts and tap try free to start your seven-day free trial. Your brain is not just this disembodied organ that is sitting in your skull connected from the rest of what's going on in your body.
1:08We learned about the blood-brain barrier in medical school, but that's ridiculous. The brain is constantly interacting, communicating with everything going on in your body. Yes, you have a blood-brain barrier, but it's not like it's something that's just inviolable. inviolable. It's permeable and things go across and impact it. So everything that's happening in your body impacts your brain. In fact, the title of my book, The Ultra Mind Solution, was how to, you know, how to fix your broken brain by fixing your body first, right? Fixing your body first. And then you can see, well, then maybe I have some issues with my thoughts and my emotions and my feelings and my trauma, whatever.
1:42But if you, if you are eating a crappy diet, if you're drinking too much, if you're smoking, if you're not exercising, if you have mercury poisoning, If your vitamin D is low, if you're B12 deficient, if your thyroid is not working, your brain's not going to work. So you just got to figure out how to get your brain healthy. So fixing your brain starts with fixing your body and optimizing all the inputs into your system and minimizing the bad stuff, right? The bad inputs, whether it's stress, poor diet, toxins, allergens, bad bugs, drugs like caffeine, alcohol, sugar, whatever is causing your brain to not work.
2:18The brain is pretty resilient and it can recover and heal given the right conditions. And I've seen miracles. I've seen people reverse Alzheimer's, reverse autism, reverse ADD, reverse depression, things that bipolar disease, schizophrenia. I mean, you just wouldn't even imagine how powerful this is. In fact, Christopher Palmer, who's been on the podcast, talked about how he used a ketogenic diet to reverse Alzheimer's and optimize mitochondrial function as a key way to treating mental illness. There's departments of metabolic psychiatry at Stanford, of nutritional psychiatry at Harvard. So we now actually have an understanding that the stuff I was talking about 15 years ago, by the way, was way ahead of its time and also extremely important to understand if we're going to fix our brains.
2:59About 30 years ago, almost, I developed chronic fatigue syndrome and it felt like I had dementia, depression, and ADD all at once. My brain was broken. I really couldn't focus. I couldn't pay attention. I used to be able to see 30 patients a day, remember all their medical history, dictated at the end of the day with no problem. I couldn't remember where I was at the end of a sentence from where I started. I couldn't read my kids a book out loud and actually understand at the same time my brain really was broken. I couldn't sleep. I was exhausted. And I learned that I had mercury poisoning and that broke my brain.
3:36My brain was just a mess. I had terrible brain fog. I couldn't focus for much time. I was a physician trying to practice medicine. It was really tough. I couldn't even remember my patient names. And I knew I had to do something different. And that's when I discovered functional medicine almost 30 years ago. And when I reversed my chronic fatigue, when I detox from mercury, when I fix all the other systems in my body, my mitochondria, my gut, my immune system, everything that was going wrong, I was able to reverse my chronic fatigue syndrome and my brain got better. And since then I've written 18 books in 20 years, my brain is great.
4:10I feel good. and I'm sharper, faster, and better than ever. So what's the worst things we do for our brains? Well, we have too much sugar and fine starch carbs and not enough good fats and not enough intake of the right nutrients. A lot of nutrient deficiencies, omega-3s, vitamin D, magnesium, to name a few that are critical for brain health. And that affects over 50 to 90 % of the population with deficiencies in those nutrients. Also, we're exposed to all kinds of weird things in our diet, There are chemicals like artificial sweeteners, like MSG, environmental toxins that actually cause damage to the brain.
4:46Heavy metals, all these things damage our brain. So a lot of things cause brain damage, not just what I mentioned, but things like lack of sleep, too much stress, not exercising, overuse of certain substances like alcohol or other drugs. Now, I found over the years, really fascinating to me, it's really quite amazing that people don't connect how they feel with what they eat. or how much they rest or sleep, you know, how much they exercise or how much time they take for friends and community and connection and, or how much bad news and media they're exposed to. I had a patient said, geez, doctor, I'm so tired.
5:23I don't know what to do. I'm always tired. My brain's not working. I said, well, how much do you sleep at night? He goes, well, five, six hours. And I'm like, well, get eight hours sleep and try to see what happens, right? So don't connect the dots. Now, once you make those connections, you can start to change those simple habits. It can have profound effects on your health long-term and make a lot of little small changes that can make profound impact. Now, feeling fully focused, fully energized, having great brain health, it requires really following the principles of functional medicine, which is taking out the bad stuff and putting in the good stuff.
6:00It's taking out the bad food, toxins, allergens, microbe stress, us adding in the good stuff, the right whole foods, nutrients, bouncing hormones, light, air, water, sleep, relaxation, connection, meaning, love, purpose. All these things are necessary for our brain to function properly. And most of us don't get enough of the good stuff. We don't get whole real food. We often are deficient nutrients. We're not exposed to natural light. We don't get enough fresh air. We don't drink clean water because most of it's polluted. We don't have periods of deep rest and relaxation. We don't sleep enough.
6:30We don't live in rhythm. We don't exercise. We're to focus on being busy in our careers and all kinds of stuff to focus on community and meaning and purpose and love. And so we basically have to optimize those things in order for us to be healthy. One of the things that I really focus on, well, food is the number one thing that controls your brain. And we've seen miracles by simply people changing their diet from treating depression to Alzheimer's to everything from ADD to even schizophrenia, as I mentioned. So eating real food is so important. When I say real food, I mean real food, not processed food or ultra processed food, whole, organic, fresh, local, unprocessed food.
7:09Basically, it has a barcode or label you might want to get rid of. If your great grandmother wouldn't recognize it as food, don't eat it. Does she know what a Lunchable is or a Pop-Tart? Probably not. Junk food is just bad. Fast food is bad. Ultra processed food is bad. Some processed food is okay. A can of sardines is processed, right? It's in a can. It's got salt, maybe oil. A can of tomatoes is processed. It's tomatoes, water, and salt. That's okay. But if you can't recognize where it came from, like a pop tart, you probably don't want to eat it. And some things that seem like real food are really not, like yogurt.
7:43Yogurt is often filled with high fructose corn syrup, colors, additives, gums, thickeners. All these things are pretty, pretty nasty for us. Also, you want to eat a lot of colorful fruits and vegetables. I know you say this all the time, but these are full of phytochemicals. These impact the brain, the deep dark reds, yellows, oranges, greens, blues are so important because the color is where the phytochemicals are. It's where the medicine is. These are anti-inflammatory compounds or detoxifying compounds, antioxidants, they're mitochondrial boosting, energy producing compounds, brain powering molecules.
8:16We need to eat that. So get lots of colorful plant foods, blueberries, dark green leafy vegetables. um also go for the slow carbs not the fast carbs right i'm not saying no carbs i mean basically broccoli is a carb right but it's quite different than white bread or from sugar cauliflower and ice cream are all carbs right but it you know cauliflower is good for you but an ice cream sundae probably not right so eating whole plant foods also will have lots of fiber helps to reduce the surges of sugar that cause some of the problems. In fact, we call now Alzheimer's type 3 diabetes. It's like diabetes of the brain from too much sugar.
8:56So eating lots of fiber helps slow the surge of sugar, nuts, seeds, lots of veggies, whole grains, beans, all really can be very helpful. And it also keeps your gut healthy. And by the way, your gut and your brain are connected. You need to maintain your healthy microbiome to actually protect your brain health and prevent Alzheimer's. Also fat. The brain is made up of 60 % omega-3 fat. It's mostly fat in your brain. So you need to be a fathead. And going on low-fat diets are pretty bad for the brain. In my book, Eat Fat, Get Thin, I talk about fats a lot and when they're good fats, when they're bad fats, and how to get the omega-3 fats from your diet, from algae or fish.
9:39Um, my brain worked pretty good before, but, um, I actually have gotten on a better fat diet, including some things like MCTL, which is really powerful for the brain. And my, my focus and my clarity has just gone through the roof. Now also want to optimize protein. We need protein because if you lose muscle, because you don't eat enough protein, it leads to this cascade of problems with low muscle mass. fatty deposits in your muscle, leads to prediabetes, lowers your testosterone, which you need for brain function, lowers growth hormone, which you need for brain repair, increases cortisol, which causes brain damage, literally causes the shrinking of your hippocampus, the memory center of the brain.
10:22So you want to make sure that you're having enough protein, ideally animal protein, which is better able to build muscle. And when you age faster, your brain takes a hit, it shrinks. So you can keep your brain good by eating good fats and the right amounts of protein, omega-3 eggs, protein shakes. I like regenerative-based goat whey for a protein shake in the morning, nut butters, fish for breakfast. All that is great. Also, stop poisoning your brain. Get rid of all the bad stuff, sugar, high fructose corn syrup, trans fats, food additives, preservatives, environmental chemicals, all which really are a problem.
10:57Supplements also very important for the brain. A good quality multi-magnesium is important for the brain, calms the brain. It reduces the stimulation of the NDMA receptors, which is actually producing Alzheimer's risk. Vitamin D is important for the brain. Omega-3 fats, probiotics, all the B vitamins, folate, B6, B12 are critical for your brain and your neurotransmitter function. And you can find all these versions, the best versions, the cleanest versions at my online store, store.drhyman.com, along with other brain boosting supplements. So you need to design a plan for your life that includes your overall health, but you ought to incorporate some of these important practices for your brain.
11:37But the good news is what prevents brain problems, prevents heart disease, prevents cancer, prevents diabetes, and everything else. So not like you do a million different things, but these principles are really important for brain health. Happiness is a brain function. So that's number one. When your brain is unhealthy, you're likely to be unhappy and so you know it's like why did i write this book it's like americans are the unhappiest they have been since the great depression so given the pandemic the political divide the societal unrest uh social media and the national media controlling the dialogue and And they go after fear because that activates the limbic structures in the brain that gets people to pay attention.
12:33And so we're getting it. Fear, fight or flight. It's the reptile. So they appeal to your reptile. They do. And a lot of people wake up with negativity and sadness because that's been planted in our brain through evolution. because thousands of years ago, you had to wake up and be afraid because that was a survival mechanism. So that is why the brain pays attention to negativity faster than to positive messages. And I'm like, okay, we're so unhappy that I want to spend a year thinking about studying, writing about happiness. And so I got 500 consecutive patients, Damon clinics, and we gave them the Oxford happiness questionnaire.
13:28And then we looked at their brains and what we found, the unhappier you were, the lower activity in the front part of the brain you have and the lower activity in an area of the brain called the basal ganglia, which has the nucleus accumbens, which is the part of your brain that responds to dopamine. And so things like head trauma or toxic exposure, and so much of it I learned from you. I don't know if I, I know I've told you, but you've just been a huge mentor of mine that I buy your books for all of my doctors we have almost 70 doctors now thank you i'm getting so many royalties thank you and i love uh looking at at the brain you know that's sort of my thing what i do and it was just so clear if your brain wasn't healthy you were not likely to be happy so the first strategy that nobody knows about is get your brain right and your mind will follow uh and there are a whole bunch of strategies on how to do that the second one which i just stop you right there could i just that is such an important statement you just said i don't want to go over it so quickly your brain is your brain which is this you know putty like structure in your skull and your mind is who you are it's your thoughts it's your feelings it's your perceptions and your mind function is determined by your brain function and yes you can overpower your brain function if you're really strong-willed in many ways but it's really important insight to understand that your brain and the quality of the health of your brain determines the quality of your mind that's a big insight that most people don't realize your brain creates your mind right if you live sad i'm depressed i'm anxious they go oh it's it's it's like a sore ankle it's like a like a like a like a stomach ache but your brain can't have a stomach ache or a sore ankle so it has a mood change right so you and i've been blessed to see some really cool people and i was in justin bieber's docu series in 2020 called seasons and he came to me at a really low point and like many of these young superstars.
15:53They'll show up or not. They'll do what you say or not. And when he got really low, he showed up and he said, I think I get what you're trying to tell me. My brain is an organ, like my heart is an organ. And if you told me I had heart problems, I'd do everything you said. He said, so I'm going to do everything you say. Changed his diet, did hyperbaric oxygen, and IV therapy. And he's better now than ever. He was just nominated for a bunch of Grammys that I'm so proud of him. But if you don't get your brain right, it's really hard. You know, if you think of it like hardware and software, got to optimize the physical function of your brain and then you can program it.
16:42And we have faulty programming. We'll talk about that. But you first have to get the hardware right. Exactly. So keep going on the seven things. I stopped you after the first one. So the second one is happiness is geared to your brain type. One of the big lessons I learned from imaging early on is that all psychiatric illnesses, all of them, are not single or simple disorders. they all have multiple types. Giving someone the diagnosis of depression is exactly like giving them the diagnosis of chest pain. And nobody thinks about it like that, but it's absolutely true that, you know, nobody gets a diagnosis of chest pain.
17:34Why? Because it doesn't tell you what's causing it, and it doesn't tell you what to do for it. I mean, you're not going to give everybody nitroglycerin. I mean, that would be stupid, right? But now we think of depression. Oh, you're depressed. Take Lexapro or you're depressed. Take Luvox, which is really interesting. We may talk about that in the pandemic, but. Yeah, it turns out it's a good group for COVID. Yeah, it's really interesting. And I think I know why, but ADD is not one thing. It's seven different things. One of my bestselling books of all time, Healing ADD, I talk about seven different types.
18:11And then when I was thinking about happiness, I'm like, the thing that makes spontaneous people happy, like scary movies and having an affair or jumping out of an airplane, the persistent person would actually, those things would make him or her miserable. And so it's really important to know your type. There are five primary types. You balance. That means, you know, most any reasonable thing will make you happy. Spontaneous. You need novelty or you're not happy. Persistent. You need routine or you are not happy. Sensitive. You need connection. They were damaged most in the pandemic with the isolation.
18:59And the cautious people, they need peace to make them happy. And so know your type. I have an online quiz called our Brain Health Assessment, brainhealthassessment.com. You'll see which of the 16 types you have. And then, well, what are the things more likely to make you happy? And all of these strategies have questions. and for get your brain right. The question, the little tiny habit, I don't know if you know BJ Fogg, but I worked with him. Yeah, yeah, yeah, yeah. Six months on tiny habits. So we have 50 tiny brain habits. But the mother of all tiny habits for the brain is for strategy one, is this good for my brain or bad for it?
19:49So when you go to do something, you just ask yourself, is this good for my brain or bad for it?
20:03so when we were at saddleback our first fight with pastor warren was you got to get rid of the donuts are it's good for your brain or bad for it i mean obviously it's bad for i don't know if you remember that but i do as a soda the pancake breakfast and the miscute initials we had to work that out they did good though i would say they i was impressed that the scale of change that they did so quickly it was very impressive it's amazing and then the question for the second strategy am i doing something today that makes me uniquely happy so it's really diving into happiness is not the same thing for everybody so don't say it's novelty and gratitude and appreciation and fun and comedy because it's different based on your type.
20:57Three, you'll appreciate is supplement your brain. We live in a society of deficiencies. And if you're nutrient deficient, especially serotonin, you know, most people don't know that birth control pills deplete serotonin. And I've seen this over and over in teenage girls, They go on birth control pills and now they're anxious or they're depressed and no one's thinking. It's changing their neurotransmitters. And my favorite happy supplement is Saffron. I've been following the science of Saffron for 20 years. 24 randomized controlled trials against Prozac, Paxil, Zoloft, Omipramide, Afexor. equally effective.
21:52But rather than being anti-sexual, you know, put someone on an SSRI and they have trouble having an orgasm or their libido goes down, saffron is pro-sexual. And it makes them more interested. And there are studies showing that saffron helps with memory, even in people with mild cognitive impairment so when the pandemic started i just released a product i love called happy saffron saffron zinc and curcumens and i'm like right we got a pandemic my dad died i had to close our manhattan clinic i mean it was a disaster i'm like i'm taking this so this is the supplement i take many of them but that's my favorite one and so i i think we might agree probably everybody should take a really good multiple vitamin.
22:47Everybody should take an omega-3 fatty acid. You should optimize your vitamin D level, test it. Odds are it's low. And then work to get it high normal because we're in a pandemic. And then it depends on your brain type. So our spontaneous people do better with stimulating supplements like rhodiola. Our persistent people do better with serotonin boosting supplements like 5-HTP. The sensitive people do better with saffron or SAMI. And the cautious people do better with GABA, theanine, magnesium. I'm just a huge fan. And too often you see this is people go to their family doctor, their nurse practitioner, and they end up on a benzo.
23:39And it's like, no, no, no. That's like 20th on the list. Let's do meditation, diaphragmatic breathing. Let's try GABA and magnesium. Please don't do that because why would you start something? Somebody can't stop. And I see them creating so many problems with inappropriate medication use. Well, they don't even work that well. That's the thing. If you took Prozac and you're cured and you're happy, life was good, wonderful. But it just basically no better than a placebo for mild or moderate depression. So, you know, that's another problem. Well, the pharmaceutical industry doesn't want to be in the order business.
24:26I mean, they consciously made the decision to be in the reorder business. that once you start something for a lot of psychiatric medications, they change your brain to need them in order for you to feel normal. So many people are just wickedly afraid of going off antidepressants because of the withdrawal from them. And I'm not opposed to medication. I'm just opposed to that's like the first and only thing you do without getting someone's diet right, without getting their habits right. Well, that's so true. I mean, you also talk about in the book this whole idea of four circles of happiness as an exercise to make you happy.
25:12What is that? Well, when I was in medical school, actually the first week, our dean came in the classroom and he said, never think of patients as their diagnosis. Always think of them in four big circles. And it's just stuck with me. He went to the board and he drew the first circle, which is the biological circle. So, you know, as a doctor, you need to know all about their biology. And as a psychiatrist, for me, you know, our primary organ is the brain. So brain health, as we talked about. The second circle is the psychological circle, which involves development and how they think. and secret number five is master your mind and gain psychological distance from the noise in your head which we'll talk about super fun circle but it's basically the psychological circle well one of my favorite things you said is uh never don't believe every stupid thought you have and and i didn't learn that till i was 28 years old in my psychiatric residency of the Walter Reed Army Medical Center.
26:21And I'm like, my eyes got really big because, you know, I've struggled with anxiety. And I'm like, why didn't they teach me that in third grade? Right. Just because I have a thought has nothing to do with whether or not it's true, whether or not it's helpful, whether or not I should attach to. And it's not the thoughts you have that make you suffer it's the thoughts you attach to that make you suffer um and then he drew the third circle which is the social circle he said in the social circle it's how are your how are your patients relationships and what's their social situation and you know two years into this pandemic, the social situation for so many people has just been a disaster from the societal unrest, the political divide.
27:14At Christmas, I had never seen family division like I have seen. And I'm saddened by it. And I kept telling my patients over and over and over again, without connection, you have no influence so you're a vaxxer you're an anti-vaxxer whatever you know that people are like not getting together and angry at each other and i'm like if you don't stay connected you have no influence on the other person um and then the last circle which i just love so much is the spiritual circle it's why do you care you know what is your deepest sense of meaning and purpose is your relationship with God, with the planet, with the past, with the future, and really talking about that with my patients.
28:08And I have to tell you, Mark, nine out of 10 patients, when I ask them what their goals are and why they think they're on the planet, they haven't thought about it. And I'm like, you know, a business is not going to go unless it has a mission statement and a purpose and a strategic plan. And so that's actually number seven of the happiness secrets is live each day based on clearly defined values, purpose, and goals. And purposeful people are happier. But if you don't know, and there's a great exercise in the book on how to find your purpose that I love. And, you know, one of my favorite patients that came out last year that I've been her doctor for about 11 years is Miley Cyrus.
29:02And I love her so much. And she has just grown up so much in the last couple of years. And she's very purposeful. She knows what she's about and what she wants to accomplish. And her bad habits didn't fit. And ultimately, that's the question to ask for secret number seven is, does it fit? Does my behavior fit the goals I have for my life? You know, especially when you look at the statistics, if you get to be 75, one out of two people will have diagnosable Alzheimer's. If you get to be 80, I'm sorry, one out of three, if you get to be 80, one out of two people. Yeah. This didn't exist 100 years ago before Dr.
29:50Alzheimer's got to put his name on this illness he identified. In the Amazon, the thing that amazed me is that the incidence of dementia is one out of 100 people. There's very little heart disease. There's 1 % there and 20 % here. 20 % here. It's crazy. And it's, of course, related to our lifestyle. So learning how to grow a new brain, pretty important topic. It's really important. And remember, the brain is fat. So you've got to give it a good fat. You cannot turn on the higher brain until you go first on a ketogenic diet. And it doesn't need to be, you know, eating meat three times a day. But you've got to go into autophagy.
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30:29You've got to go into start recycling cellular waste and eliminating. And we know how to do that now. The beauty of it is not only do we have the diagnostics. We know how to reverse this stuff. we know how to create a new brain we know how to help people grow a healthy brain that's not only going to prevent the dementias it's going to let them step into this place of gnosis of wisdom yeah it's interesting you know we've had chris palmer on the podcast i'll probably have him back again who's a harvard psychiatrist talking about mitochondria as the core dysfunctional unit that is causing most mental illness everything from autism to schizophrenia to depression and disease and then we have to treat the mitochondria but you're also saying that in terms of the aging brain and not just not just that but also just having a healthy brain you really have to focus on you got it so how does that come up in your book you know the mitochondria it's a big section on mitochondria and how do we restore mitochondria they're fuel factories inside every cell and your brain and your heart have the highest concentration of these fuel fact energy factories in mitochondria but they're not only producing energy, they are actually in charge of the death clock.
31:43And whoever runs the death clock runs the show. They tell cells when they need to die so new ones can be born, so regeneration can take place. But mitochondria, they don't belong to us. They are actually bacteria that join our cells. formed a eukaryotic cell millions of years ago so that it cut a deal with these multicellular organisms saying hey i'm going to give you energy you keep me protected keep me warm keep me safe and that's what that's what they do but what they do is they turn basically they store energy in the form of sunlight yeah of atp of a molecule called atp adenosine triphosphate this is like the little sparklers that kids use and when that they're depleted that energy becomes goes from being atp to adp adenosine mono amp adenosine monophosphate your fuel tank is empty yeah and the um so this process of storing energy of processing energy of protecting the mitochondria who have 38 genes in a ring that are unprotected because our dna is 24 000 genes and a double your brain cells have more mitochondria than any other cell in your body for cell and they are the feminine life force like 20 000 50 000 per neuron per cell yeah and we only get the mitochondria from our mothers so they're they're what the i heard the amazon shaman saying you know your people their feminine life force is very weak and then david perlmutter said to me of course his mitochondria that's right that's right because we get it from the mother so how do we protect repair and here's where we get into zombie cells yeah it's also about zombie cells these are the zombies like did like the ones in Haiti the spirituals no you're not talking about that we kind of because zombie cells these cells are neither living or dead and they're actually a cancer protection mechanism that every cell has so if a cell is not able to copy its dna's information accurately to a daughter cell mother cell they're they're mother cells and daughter cells there no they're no daddy cells if it doesn't copy correctly it'll neuter that cell so it cannot replicate yeah because we call that metastases.
34:16So it'll neuter it, but it won't kill it. So these cells are not able to reproduce. They're neither living nor dead, but they're mitochondria. They become fat and swollen and are starting to produce chemical signals, chemokines, cytokines, that are pro-inflammatory. And they're very toxic. But it's a cancer protection mechanism. But when you have too many of these, remember the problem here is the copying. if the copying is not accurate they get neutered and what interferes with the copying is a signal to noise ratio all the toxins we're exposed to these cells begin to build and we end up with cancers these these senescent cells are called and they were discovered by james kirkland at mayo clinic who did a beautiful gerontologist who said i'm tired of prescribing walkers and wheelchairs, how do we begin to deal with the causes of aging?
35:10And he found that there were senolytic agents that actually switched on, the kill switch, turned it back on in these cells. And you could get rid of them. You could do away with them. You could kill the zombie cells, which are also called senescent cells. Senescent cells. Senolytic is, senescence is aging, and senolytic means to kill aging. Yeah. Kill the aging cells. Kill the aging cells. So how does that work? How do you do that? Well, we don't know exactly, at least I don't know how they work, but they seem to switch back on the kill switch in mitochondria. And what are the therapies they're using?
35:46And those therapies are combining things like quercetin and fisetin. Fisetin is made from strawberries. Yeah. And quercetin is polyphenol. It's made from onion skins, from a variety of products, natural products. And it's a hit-and-run intervention. four or five days and and i have a senolytic protocol that we use in in our retreat center in chile that you've been to and uh in four or five days you do away it's a one and done treatment that you need to repeat we're finding out three or four times a year because we got 40 years or 50 years of senescent cells in us and that what that does is to basically reset the system you don't have this burden of zombie cells that you need to that you're that you're functioning with it cleans you out yeah it's true also there's a great study out of israel where they looked at i talked about in my book young forever where these hyperbaric oxygen over 60 sessions i actually I'm doing it right now.
36:49I just came from it because of my back surgery to heal the wound. But the beauty of the hyperbaric is that it actually creates a stress, but it also kills the zombie cells. Yeah. Yeah. And this is, I think, essential. Absolutely essential. Our protocol is not only fisetin quercetin, which is commonly used for this, because this will kill the zombie cells. But how do you get rid of them? So you've got to work on the transport system and support the liver in eliminating them. So we're combining it with alpha lipoic acid and with liver support, including glutathione or glutathione, to help to transport and eliminate them out of the body so they're not just sitting there.
37:32This is amazing. We're talking about mitochondria, zombie cells, a microbiome, serotonin, trauma. But see, this is plant-based. This is working with... And the reason you're going to hear a lot more about senescent cells is because we're getting to molecular solutions, to pharmaceutical solutions. Yeah. But this is available today. Fisatin is strawberries. You'd have to eat 30 pounds of strawberries to get the same effect. You can take it as a supplement. But it's an amazing supplement, four or five-day intervention that lowers your burden of these toxic cells that are pro-inflammatory. Yeah. One of the things that, you know, it's so fascinating is that, you know, we can start to embed these practices into our daily life.
38:21And you've written this book, Growing a New Brain, which is not just talking about the theory. You talk about case stories. You talk about how to do it. And how to do it. Yeah. So can you maybe share some stories about how this would be applied? What are the kinds of things people are doing? How does it work? First, let me share a story about how I kind of got into on this track. because I was running a small lab at San Francisco State. We were looking at, can we create psychosomatic health? What are the mechanisms? And I got frustrated at one point, shut the lab down and went to the Amazon to see what they did.
38:58People that had no technology, but they had the plants, the natural world, the plant world, and the mind, the power of the mind to create. We know the placebo effect is the most tested medication in the world yeah because every pharmaceutical is tested against placebo and we know it's extraordinarily effective yeah i mean it's 68 as effective as morphine in the case of gunshot wounds amazing so i began looking at what's the placebo effect we we don't know what the mechanism is but we know it works we know it works even when the person you're giving the sugar pill to knows that it's a placebo. That's amazing.
39:42It's extraordinary. A lot of the shamanic healing is based on mobilizing this resource that we have to create health that we call that we dismiss derogatively as a placebo. That's just a sugar pill. Well, most of what you're getting in your pills that you take. Well, you're activating your psychopharmacology because I always say the the best pharmacy is the one between your ears the one between your ears yeah so this is how what i became interested in and so how do we do that for ourselves well meditation seems to be one of those things um practicing inner peace breathing practices that begin because that's the interface between your um that can allow you to self-regulate your your physiology and your nervous system so i think we have to discover what works for us we have to provide the brain with the neural nutrients the support get the serotonin we're serotonin depleted right now and and this is things that we can do immediately and then turn your kitchen into your laboratory and then take part in what why this number of people are calling the experiment of n is equal to one yeah where you have you know in medicine if you have a research project you want to end a number of participants to be as big as possible but here the experiment is n is equal one it's my experiment is called alberto yeah yours called mark i love experimenting on mark yeah me too and the problem the thing is that if you don't do the experiment you get to be in the control group and the control group is deadly statistics yeah you want to be an outlier in that bell curve so we need to take control of our brain today not outsource it to our digital devices like we've done you know the our memory functions are all outsourced to our digital devices i was writing one of our blogs today and i said this thing popped up do you want help with writing this blog It was chat GPT asking me if I wanted me to do it soon.
41:49We're only going to be here to clean the machines. So we need to really upgrade our brain, take the next step in human evolution. Because the one interest couple interesting details. There are 40 million species in this planet, more or less. And only three of those don't have a death program in their DNA. And they're humans, dolphins and whales. Every other species in nature has a death program. There are no grandmothers in nature. They're eliminated. Whereas we not only have grandmothers, but we can live 30, 40 years after menopause. There's no menopause in nature. It doesn't exist. Nature is doing a biology experiment with humans, dolphins, and whales in longevity.
42:33And to take part in that experiment, we need to be proactive in it. We need to attenuate the systems that create psychosomatic disease, the amygdala, the production of cortisol and adrenaline, and switch on the production of the psychedelics that the brain produces to awaken the higher brain. It requires the psychedelics. Well, let's talk about that. I was going to close with this because I think this is really an important framework. because historically we thought of psychedelics as causing psychological effects but but now we know they're causing biological effects and literally structural and functional changes to the brain incredible example by increasing bdnf and other brain trophic nutrients things that are helping the brain grow repair heal reduce inflammation and and things like you know dmt from ayahuasca from you know the bufo from the sonoran desert toad the you know psilocybin medicines mdma which is synthetic chemical lsd synthetic chemical or but that comes from a plant ergot all these are are things that have been around for hundreds of thousands and they all act in serotonin receptors and they act on the serotonin receptors but what we're now learning about them is it that they can really create profound lasting changes in the brain in a way grow a new brain.
43:59Tell us how you think about that. It's amazing. If you've seen the brain on drugs, on psychedelics, you find that there are 20 to 30 times the amount of neural networks. Not the Richard Nixon brain on drugs with the fried eggs. Not the one with the fried egg. Yeah. And the problem is that many, so we're doing this experimenting without a traditional sacred structure. So every culture that works with psychedelics knows that you need a diet to prepare for it a diet that's rich in serotonin for example and some of the mao inhibitors yeah and you need to prepare a sacred space a safe space not just drop some acid or give somebody some ketamine and uh but even then tremendous healing happens so that's the chemical effect is what we're looking at other societies looked at the sacred what was the environment how do you create a safe space?
44:53How do you are able to commune with the divine in whatever form you encounter it? And that's part of what we're looking for, that we don't have the answer for that. That's true. I think it's true. But I think what's what's sort of exciting to me is it sort of is a sort of revolution brain science, and the revolution and trauma healing, the revolution, psychedelic medicine, the revolution and understanding the body as a system and network, all these things are coming together. And I think it's going to change everything. We think about the brain, the mind, our lives. Totally. It's going to open up the door to explore the mind.
45:30So what does the future look like? Tell us about how you see the future. I am very optimistic. I see the future is tremendously exciting. I think that there have been five extinction events in the planet before we're living in the fifth one right now. It started about 15, 20 years ago. More species are dying than the previous one. that's when a gigantic meteorite struck the earth and wiped out 90 % of life forms. Wow. During extinction events, nature seems to take the foot off of the brake and step on the accelerator, evolutionary accelerator. So it's not only evolution in between generations, but now within generations, that we can become a new human.
46:08What's called epigenetic reprogramming? Epigenetic reprogramming to become a new human being that can have long life, long health, and can become a keeper, an earth keeper, a steward of the earth, and can experience her and his divine nature. So beautiful, Barto. I think of it a little scientifically, too, which is that this concept that's emerging from our scientific discovery, in a way, we talk about shamanic healing, we talk about energy medicine, and we talk about kind of healing from trauma, that this fundamental concept of epigenetics, which is relatively new, it's the idea that there's a control system regulating our genes, that our genes are fixed, but which ones are turned on or off is regulated by this sort of master coder.
47:01And the coder is the epigenome. And that gets programmed generationally. So trauma can be transmitted generationally. Totally. The impact of toxins or crappy food is transmitted generationally. And those impacts are found downstream two or three generations down. So if your grandmother was exposed to glyphosate, you're at risk for all sorts of cancers and deformities, right? If your great grandmother had a trauma, then that might be embedded in your DNA, like the Holocaust survivors. Precisely. My children and their children and their grandchildren have very low levels of cortisol that's been happening for generations.
47:35So what's exciting is what you're talking about essentially is using the site of science to reprogram the epigenome So you can evolve within one generation. So there was this debate between Darwin and Lamarck. Darwin was like species evolved through natural selection over time. Lamarck was like species come fixed as they are. They're both right in a way, right? And so these traits, and he was like traits can evolve even in a generation. So I think - Very rapidly. Yeah, very rapidly. Not only that, but we inherit not only the toxic legacy of our ancestors, both biological, chemical, emotional, but also the gifts, the extraordinary gifts of resilience, of courage, of endurance, of bright, you know, and we have to begin to tap into that.
48:19Dr. Mark Hyman:If you love this podcast, please share it with someone else you think would also enjoy it. You can find me on all social media channels at Dr. Mark Hyman. Please reach out. I'd love to hear your comments and questions. Don't forget to rate, review, and subscribe to The Dr. Hyman Show wherever you get your podcasts. And don't forget to check out my YouTube channel at Dr. Mark Hyman and for video versions of this podcast and more. Thank you so much again for tuning in. We'll see you next time on The Dr. Hyman Show. This podcast is separate from my clinical practice at the Ultra Wellness Center, my work at Cleveland Clinic, and Function Health, where I am Chief Medical Officer.
48:50Dr. Mark Hyman:This podcast represents my opinions and my guests' opinions. Neither myself nor the podcast endorses the views or statements of my guests. This podcast is for educational purposes only and is not a substitute for professional care by a doctor or other qualified medical professional. This podcast is provided with the understanding that it does not constitute medical or other professional advice or services. If you're looking for help in your journey, please seek out a qualified medical practitioner. And if you're looking for a functional medicine practitioner, visit my clinic, the Ultra Wellness Center at ultrawellnesscenter.com and request to become a patient.
49:22Dr. Mark Hyman:It's important to have someone in your corner who is a trained, licensed healthcare practitioner and can help you make changes, especially when it comes to your health. This podcast is free as part of my mission to bring practical ways of improving health to the public. So I'd like to express gratitude to sponsors that made today's podcast possible. Thanks so much again for listening.
From the publisher
Not long ago, conditions like Alzheimer’s were rare, but today, nearly one in two people over 80 are diagnosed with it. In contrast, in places like the Amazon, dementia affects only about one in a hundred—highlighting how modern lifestyle plays a major role in brain health. The brain isn’t an isolated organ; it’s deeply influenced by diet, sleep, movement, stress, toxins, and emotional well-being. Many people who once struggled with brain fog, depression, or memory loss have experienced dramatic improvements by healing their bodies—addressing gut health, detoxifying harmful substances, optimizing nutrition, and supporting the brain’s energy systems. With the right tools, including targeted nutrients, lifestyle changes, and even therapies like breathwork or plant medicines, it’s now possible not only to protect the brain from decline but also to enhance clarity, focus, and resilience at any age.
In this episode, I discuss, along with Dr. Daniel Amen and Alberto Villoldo, how the body and brain are intimately connected and how we can think and feel better when we address our overall health first.
Dr. Daniel Amen is a physician, double board-certified psychiatrist, twelve-time NY Times bestselling author, and founder and CEO of Amen Clinics, with 10 US locations. Dr. Amen is the author of many books including the mega-bestseller Change Your Brain, Change Your Life, as well as The End of Mental Illness, Memory Rescue, Healing ADD, and Your Brain Is Always Listening. In March 2022, Tyndale will publish his new book, You, Happier: The 7 Neuroscience Secrets of Feeling Good Based on Your Brain Type.
Alberto Villoldo, Ph.D., is a medical anthropologist, psychologist and shaman, who studied the spiritual practices of the Amazon and the Andes for more than 30 years. While at San Francisco State University, he founded the Biological Self-Regulation Laboratory to study how the mind creates psychosomatic health and disease. Founder of The Four Winds Society, he instructs individuals throughout the world in the practice of energy medicine. Dr. Villoldo has written numerous bestselling books, including Power Up Your Brain: The Neuroscience of Enlightenment (with David Perlmutter MD), Shaman, Healer, Sage; and WSJ bestseller One Spirit Medicine.
This episode is brought to you by BIOptimizers.
Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%.
Full-length episodes can be found here:
What Damages Your Brain And How To Reverse ItHow Creating A Healthy Brain Creates A Happy MindHow to “Grow a New Brain” for Lifelong Health
