#104: Intelligence Beyond the Brain - Nikolay Kukushkin, PhD

15 Jul 2025 · 1 h 12 min

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FitMind Podcast Episode #104: Intelligence Beyond the Brain - Nikolay Kukushkin, PhD

Episode Overview In this episode, host Liam McClintock interviews Dr. Nikolay Kukushkin, a neuroscientist who presents groundbreaking research suggesting that memory and pattern recognition are not exclusive to brain cells, but can also occur in non-neuronal cells. The discussion delves into the implications of this research on our understanding of memory, trauma, and cognition, alongside the parallels between artificial intelligence and biological intelligence.

Key Topics Discussed

  1. Memory Beyond the Brain
  2. Cells as Memory Storage: Dr. Kukushkin argues that memory capabilities extend beyond the brain, with individual cells capable of recognizing patterns and storing information.
  3. Memory in Non-Neuronal Cells: Research indicates that even common cells, like kidney or skin cells, exhibit memory-like properties, challenging traditional notions of cognition confined to neurons.
  1. Lessons from Sea Slugs
  2. Simple Models for Memory Studies: The use of sea slugs as a model organism allows for the observation of basic memory processes, as they possess a simpler neurological structure that can still provide insights into memory formation.
  1. Nature of Memory
  2. Definition of Memory: Dr. Kukushkin defines memory broadly as any occurrence where short-term inputs lead to long-term changes in an organism's behavior or state.
  3. Memory and Trauma: The episode explores the possibility that trauma could be stored at a cellular level, prompting a reconsideration of how we approach psychological healing and the treatment of trauma.
  1. Cognition and Intelligence in Cells
  2. Intelligence as a Property of Life: Intelligence may not be exclusive to brain cells; rather, it could be a fundamental aspect of living organisms, suggesting a new paradigm in understanding biological intelligence.
  3. Active Forgetting and Memory Dynamics: The discussion touches on the processes of forgetting and whether cells can forget in a manner analogous to cognitive processes in animals.
  1. Implications for Artificial Intelligence
  2. AI and Biological Intelligence: The parallels between AI algorithms and biological intelligence prompt questions about how artificial systems might mimic or learn from cellular behavior.
  3. Potential for Integration: As AI continues to evolve, integrating more biological processes could lead to more nuanced and adaptable systems.
  1. Philosophical Considerations
  2. Consciousness and Memory: The conversation addresses the philosophical implications of memory storage and consciousness, particularly regarding how both might be influenced by cellular processes.
  3. What it Means to be Human: Drawing from both scientific and philosophical perspectives, Kukushkin's upcoming book, "One Hand Clapping," explores the nature of human consciousness and individuality in a universe governed by the same fundamental principles.

Conclusion Dr. Kukushkin's research invites a radical reassessment of how we understand memory, cognition, and intelligence, suggesting that these phenomena may not be as exclusive to the brain as previously thought. The implications of these findings could transform not only neuroscience but also our broader understanding of life and consciousness.

Links and Resources

  • [FitMind Neuroscience-Based App](http://bit.ly/afitmind)
  • [FitMind Website](https://www.fitmind.org/)
  • [Dr. Nikolay Kukushkin's Website](https://www.nikolaykukushkin.com)
  • Follow Dr. Kukushkin on X: [@niko_kukushkin](https://x.com/niko_kukushkin)

Show Notes

  • 0:00 | Intro to Nikolay Kukushkin, PhD
  • 5:10 | Memory in Sea Slugs
  • 10:25 | Cells Can Recognize Patterns
  • 20:28 | Memory Defined
  • 23:02 | Do Cells Store Trauma?
  • 30:40 | Treatment for Neurological Conditions
  • 38:40 | Brain & Memory Connection
  • 42:25 | Optimal Interval for Superior Memory
  • 50:35 | AI Inspired by Neuronal Behavior
  • 58:38 | Consciousness in Microtubules
  • 1:06:15 | Where to Follow His Work

For those interested in the intersection of neuroscience, psychology, and personal development, this episode provides thought-provoking insights that challenge conventional wisdom about intelligence and memory.

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Transcript

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0:00The time is ripe. We are at a point when people are more willing to make this bridge between a memory of a human, a memory of an animal, and a memory of a cell. The fact that patterns matter on a finer timescale that we previously believed makes it possible that in the future we will be able to construct our experience based on what we know about how those patterns convert into what outcomes. I know it's very general at the moment. I don't have a specific technique to save yourself from Alzheimer's. But I think those techniques might exist, and it's up to us to find them out. And that's a big part of our message to the world, that when we're saying cellular memory or cellular cognition, we're not using these words in quotation marks.

0:47We mean them literally. We mean that the more advanced forms of cognition and memory are built upon these molecular tools that have been around since before there were brains and animals and humans and anything like that. So all of these processes have deeper evolutionary roots than we like to believe.

1:08Welcome to the FitMind podcast, where we explore the frontiers of human potential, meditation and neuroscience. What if memory isn't just in your brain, but in every cell of your body? Today's guest, Dr. Nikolai Kokushkin, is a neuroscientist whose groundbreaking research reveals that even individual cells, like those in your kidney or skin, can learn from patterns and store memory. We explore what this means for trauma, behaviour, consciousness and even the future of AI. We also touch on how this cellular intelligence mirrors ancient contemplative insights, where the body plays a central role in emotional healing and awareness.

1:46This conversation is a deep dive into the biology of experience, how life remembers, and it might just shift how you think about who or what you are. I'm your host, Josh, and I hope you enjoy this episode. Nico, welcome to the podcast. Thanks. Nice to be here, Josh. Great to see you, and I'm really excited to chat. So you've had an extremely colorful background, I would say. I'd love it if you could just share a little bit about your background and how it was that you got into neuroscience, in particular, the study of memory and the evolution of the mind. Yeah, sure. So my background is in biology.

2:27I'm originally a biologist. Anything that I think about in the brain, the first thing I think about is evolution. I don't think about what happened to me yesterday. I think about what happened to my species a billion years ago. That's my frame of mind. But when I first started in biology in college, I really didn't have any idea of what I was going to do, that I was going to be interested in neuroscience. None of that was clear to me. The way I thought about this originally is I wanted to do the big medical problems, you know, solve global diseases, cancer, HIV. I think that's what most people start with.

3:05And so I'm from Russia. I like to say that I'm from both a city and a country that no longer exists. Actually, I'm from Leningrad, USSR, which is an interesting fun fact. But I went to school in there to undergrad. And after that, PhD in the UK, in Oxford. That's when I started thinking more about biochemistry, smaller things, cell biology. And my PhD project was about how molecules in the cell talk to each other. So it wasn't about the minds yet, nothing to do with memory, but it was about information processing. It was about how molecules inside the cell coordinate their own activities to produce proteins for export, for example.

3:48And there was some clever information processing going on between them. Then I did my first postdoc, which was still in that line of work, still about cancer, but also a little bit about dementia. since we were working in the way that proteins are being produced, it goes wrong in cancer. It also goes wrong in some dementias like Alzheimer's, Parkinson's, frontotemporal dementia. There's some common threads between those different diseases. And so that was the first time I touched anything to do with memory. It wasn't yet about how memories are formed, what kind of information processing goes on in the brain.

4:23It was more about what breaks down in cells and neurons during dementias and these diseases of the brain. And from there on, I became more and more interested in the question, okay, what happens in health, in normal brains when we form memories? What happens to those cells and molecules when we learn, when we try to memorize something? It's this connection between the molecular and the profound, the philosophical, the mental that's most interesting to me. That's what I'm always looking for. I'm curious about how we get from chemistry, from the smallest components of a living organism, to our own minds, to our own internal perspective.

5:08So from there on, I went to the lab where I currently work. It's Tom Carew's lab. Tom Carew is my mentor and everything I know about neuroscience I know from Tom. Tom's lab has been studying sea slugs for decades. That's what it's famous for. So I joined Tom in studying these sea slugs. We studied memory and sea slugs for several years. It's not obvious to outsiders why you would go to sea slugs if you want to study memory, but actually it's a very common research model for memory studies because sea slugs are such simple animals. And not just simple, you know, when you say simple, it seems like this is something derogatory, that we're normal and they are stupid and simple.

5:52Actually, they are normal. Their level of simplicity, that's the standard animal organism, that's the normal animal brain. We are weird. We have a lot more going on that's very hard to understand. But sea slugs is your generic animal. And so I was interested in memory as a concept, as in principle, and for that you don't want all this complexity that comes with a human or even with a mouse. You want it as simple as possible, simplest memories, simplest reflexes, that gets you to what is happening inside cells, inside neurons, when those memories of a C-slug are being formed. So we studied C-slug's simple properties of memory formation.

6:31For example, one of the studies that we did was to find out, we found out that neurons, individual neurons, no complicated arrangements of those neurons, nothing complex about the brain itself, but individual cells of the sea slug can distinguish between a series of events that are escalating in intensity compared to that same exact series of events that's waning in intensity. So the only difference is the order of events. The overall intensity is the same, the nature of those events is the same, but a neuron changes itself more strongly if the series is escalating, which makes sense. whether it's a bad event or a good event, whatever it means for an animal, you want to respond to it more strongly.

7:18You want to change your cell form, a stronger memory, if it is increasing in intensity. If it's increasing, well, it's going to be more relevant to your life in the future. If it's waning, maybe it's not as important anymore. So it's a very simple form of pattern discrimination that even an individual cell can do. So that's what I was doing for a few years in Tom's lab. And from there on, you can see that it's a natural question to ask, okay, if a single neuron can tell apart patterns, well, does it even have to be a neuron? Maybe all cells can do that. Maybe even generic non-neuronal cells can tell apart different patterns.

7:55Maybe they can tell time. Maybe they can tell repetition versus the same number of events compressed, crammed in one go. And that's exactly what we found when we looked at non-neural cells. and that's our latest interest. That's what we've been studying for the past couple of years. Non-neurons. We use neuroblastoma cells that are kind of undifferentiated neurons. We use kidney cells that are even more removed from the nervous system. It doesn't even matter which cell you use, they all behave the same way. They can tell apart patterns. We administer experiences, we can call them experiences, but what they really are are chemical pulses administered at different times.

8:34We use chemicals to imitate what those cells might be hearing, what kind of signals they might be receiving from other cells. So instead we deliver those signals artificially, but we can control with what intensity we deliver those signals, for what time, in what order, and by doing that we can then monitor how the cells respond. So basically what we found is that surprisingly even very short stimuli, minute scale time patterns, have major effects on these cells. And what's most interesting is that these generic cells, nobody thought of them as being smart, they always thought of neurons as being smart, and generic cells, well they can't distinguish apart anything that happens on the scale of minutes, but it turns out that they can.

9:25It 10 minutes is really nothing for a generic cell, the cell of the body, separated by 10 minutes versus those same four pulses crammed into a single 12 minute long pulse. They know the difference. They know that four pulses separated by time is a more salient stimulus that they need to change themselves more strongly. That's our latest study published in Nature Communications in November last year. So basically the bottom line is all cells can tell apart patterns. Patterns matter. And they matter even on these very fine timescales. That's where we are. That's my life story. That's incredible.

10:02Thank you so much for sharing. I mean, that feels like a paradigm shift where, like, where do you even put that in terms of it feels like biology is kind of merging with neuroscience. I can imagine both would be extremely interested in that sort of finding. How are you finding the community to react to that? How do you measure the intensity or how do you increase the intensity? And how can you tell how the cell is reacting to the time differentiation? Sorry, a few questions. No, a few questions. Let me address the technical questions first, and then we can talk about what the conversation around this is.

10:45So how can we tell? So first of all, I have to say that these cells that we're studying, they are... artificial in that it's a reporter system. We've created these cells specifically to report to us if their memories are being formed. We don't yet know what those memories of those cells actually represent in a living organism. Just to give you a sense of what that might be, let me give you some examples that I know could be true from other research from the past. For example, the example that I always use is we have cells in our pancreas that produce insulin. The hormone insulin responds to food.

11:30It helps us absorb nutrients. When we've eaten a high calorie meal, we release that hormone, glucose, sugars get absorbed into tissues. That's what it does. So the more you eat, the more insulin you should be releasing. Let's say you've consumed an extremely large piece of food, something very sweet. You've loaded, you've maxed out on like your sugar intake. And so you've loaded up this sugar into your bloodstream and your pancreas has released a burst of insulin. Okay, so that's the response of those cells. They see glucose, they respond with this burst of insulin. Now you wait 30 minutes and you repeat the same thing.

12:09You once again load the bloodstream with the same amount of glucose overloaded. But now those same cells release twice as much insulin. So you've maxed out the first time they released this burst now you've waited and they've adjusted themselves and now they release twice as much it makes sense if you've maxed out on your sugar absorbing capacity you would want to ramp it up because well you don't want to you want to take advantage of all the nutrients that you have if you if you've maxed out well let's increase it so you can absorb all that glucose but you don't want it to constantly be ramped up because if you're producing too much insulin you'd just be hungry all the time and fatigue probably would also not be productive So this ability of these pancreatic cells to adjust their insulin responses to glucose, that's memory.

12:53And it's useful for the same reason that our mental memory is useful for us. It adjusts us to ongoing experience. So something like that would be body memory of cells around our body. It could be similar in kidneys. It could be similar in our gut, in our skin, in our bones. All of those cells have their own experiences. For the pancreatic cells, it's the experience of seeing sugar. For cells in the gut, it might be nutrients passing through the gut. For kidney cells, it might be salts and fluids. It's signals from other cells. All cells are constantly exposed to this pattern of signals that are coming from all directions.

13:37And those patterns could change those cells in ways that will later adjust what they do. Precisely what kinds of changes happen and what kinds of organs, we don't yet know. That's a whole new area of investigation that's now open. But what our cells show us is that fine inputs get converted into long-term outputs. So what are the inputs and the outputs? Artificial. The inputs are molecules, chemicals that we artificially put in that we know we picked those chemicals. Why did we pick them? Because we know that they activate in those cells the same molecules that activate in the neurons when we learn things.

14:20We already know this. We know enough about memory to know what happens when you're studying for an exam. This and this molecule gets activated in your neurons. We said, okay, what if we just directly activate those same molecules in other cells? If you imitate this learning, but in other cells. So we can do that with artificial molecules. We can basically reach into those cells and turn on those same components of the cells that are turned on in neurons. We don't yet know what turns them on in real life. We know that it's possible, but we don't know what in our bodies would be doing the same thing that we're doing artificially.

14:53And then the output of those cells is also artificial. Again, we know from neurons. We know that there are some genes that we call the memory genes as a shorthand, that are activated in neurons when we form a memory. So for a neuron to form a memory, it has to turn on this gene and this gene and this gene. And when they are turned on, they produce proteins. Those proteins travel around the cell. they restructured synapses, they changed the cell and so the cell gets modified. So you need to turn on those memory genes and there are some common genes that get turned on anytime and neuron forms the memory.

15:27So we also know that and we can also find those genes in in those cells. So what we did was to install this artificial this this artificial gene that basically has the same on button as those natural memory genes, but instead of actually producing something useful, it's producing this glowing protein that has no purpose in our cells, except it tells us that the cell has turned on its memory gene. So the cell literally starts glowing. This protein is taken from a firefly. It's called luciferase. It's a common thing to use in biology. It's a glowing protein that you can install in your cell. When you activate your gene that you're interested in, the cell produces that protein and you can detect light coming from those cells.

16:11So literally we have these cells, we're putting in chemicals and we're getting light back. That's our experiment. And we have these paradigms. We call them paradigms. They're like musical scores basically. So you see here each of these has six lines. That's because our petri dishes have six wells. So each of these wells receives a particular pattern of chemicals. So you see four pulses separated by 10 minutes. And right now we're testing what happens if you put another chemical an hour before that or an hour after that. Here is another plate that we stimulated in a different time and so on. So for every experiment we have a map like this.

16:54And then when we do it we just add these chemicals going from left to right here. you know in this particular it's like playing uh playing a piece on a musical instrument i love that there are six lines because it's literally like a musical score i just love that but it's a total coincidence yeah so so so your question was you know what how do we what do we put in what do we take out that's what we do so it's an artificial system that just tells us that these cells can tell apart patterns and so if they can cells of the body can as well your other question was what do the biologists and the neuroscientists think about this merger of the two?

17:31Honestly, I think that the time is ripe. I think that we are at a point when people are more willing to make this bridge between a memory of a human, a memory of an animal, and a memory of a cell. It seems like this would be a trivial question, but actually we've had a lot of conversation, serious conversation since this paper came out about whether or not the word memory should be used in quotation marks when we refer to memory of cells. Well, and I always fight for using it literally because, well, I don't see any reason why this would be called memory or as the memory that our neurons form would be called real memory.

18:18There's no sense that I can discern that makes neuronal memory more real than this memory. It's just our subjective bias. We tend to think that the real memory is what happens to me when I think back about to my day, when I think what happened yesterday. That's the real memory, and everything else is memory in quotation marks. But I've worked with sea slugs, And for a sea slug, well, a sea slug does not think about what happened yesterday. A sea slug does not have our awareness. So if you are going to use the word memory in quotation marks for these cells, well, then you also have to use it in quotation marks for sea slugs.

18:59And if you're going to use it in quotation marks for sea slugs, you probably should also be using it in quotation marks for mice. And if you're using it in quotation marks for mice, then what is really a real memory? So anytime you try to find this dividing line when quotation marks stop being quotation marks, you can't find it. So I think it's an important point that, yes, we like to believe that there's something more to our memory, that it's somehow more real, that there's something on top of it, something that finally converts all of these cellular molecular processes into our mind. But there isn't.

19:33There isn't. It's just the level of complexity. This is a very simple level of complexity, a very low level of complexity. In humans, it's very high. In sea slugs, it's somewhere in the middle. That's how I think about it. It's so interesting. In that respect, it might also merge with, obviously, there's a lot of discussion about consciousness currently. Like, where does consciousness, is consciousness fundamental? Does it come from matter? Like Anaka Harris has just put out a really good docuseries for anyone that's not checked it out. I've heard about it. I haven't seen it yet. it's really good I haven't listened to the the full thing yet but yeah she obviously did conscious a brief history of consciousness a few years ago as well and seems to have become even more convinced of that sort of hypotheses and if that is the case well there's obviously discussion of some sort of proto-consciousness in cells potentially so how do you define memory because obviously that will be defined different to the zeitgeist or how we think about memory so how do you define it like within the lab so i define memory as uh so there's there's a distinction between defining memory in general and defining say neural memory uh that's a more specific kind of memory but memory in general I define as any time that a quick pattern of inputs gets converted into a longer term output.

21:11When quick things cause slow things, that's basically what I call memory. That it's not a response that happens while you're doing something that disappears when you stop doing it. It's a response that's slower than what you're doing and that persists after you stop doing it. That applies to not just biological organisms. It applies to lots of things. It applies to a piece of dough. If you need a piece of dough, it becomes more elastic. And that's a memory. It's a memory of this viscous piece of matter. It doesn't have to be anything complicated for that. And so I think that is true for cells.

21:48It's long-term changes in response to short-term patterns of stimulation. It applies to sea slugs. It's long-term changes in their behavior in response to short-term stimuli. It also applies to how humans learn. It's long-term changes in our mind and our brain in response to short-term training or learning, exposure, experience. so there's there's a lot of and this has come up a lot in meditation circles that that well there's a lot of emphasis on the body actually and some of my teachers in the past have actually implied that you know that the trauma is is stored in the body and i think even within psychology that's that's been pretty well known not not to jump to knowing that memories um might be stored in cells or are stored in cells.

22:48But if it isn't exclusive to the brain, what does that mean for how like trauma and stress is stored in the body? Is that something that has been looked at yet? Or is that a little bit further down the line? It is further down the line as almost anything, since our study is basically just a proof of principle. It is really, you know, square one into trying to understand what cellular memory might mean for everyday life. But it is interesting that you ask this question because it is something that, as we were working on this study, did not even cross our mind. And yet it was the first thing that we've heard when the study was released.

23:30It was the number one commentary coming from all directions. And it made me really think about it seriously. When I first heard this idea that kidney cells have memory, therefore your trauma might be stored in those kidney cells. I thought that's not what we found, that's not what it is about. Kidney cells have kidney memories. It's not that kidney cells store the brain memories, and trauma is still a brain memory. But then, as I kept thinking about this, you know, I've changed my stance. I don't think it's as crazy as I initially may have thought. And actually, I think it maybe is quite likely that there is a mutual connection between emotional traumatic experiences and the body.

24:17We know that the brain can have an effect on the body. There's lots of chemicals, there's lots of signals traveling from the brain to the body. Cortisol, for example, a stress hormone, typical simple example. It definitely affects things in the brain. It affects our mental processing. It also affects our body. So, you know, it can easily stand as a communicator between what happens in the brain and the body. We also know that the body has the effect on the brain. For example, gut bacteria could have an effect on anxiety. You know, something that was considered insane 20 years ago, but now it's an established fact.

24:55So both directions exist. And since we know that the body can store in its state, in its configuration, patterns of fine, patterns of experience, well, it's not impossible that those fine patterns involve, for example, responses to cortisol. Just one example, but there could be thousands of others that the cells would be able to change differently depending on the pattern of exposure to the stress hormone. And maybe these changes would then feed back on the brain and change the emotional state in one direction or another. Now, I don't have any evidence that that is the case. But I don't think that this is unprecedented or unlikely even anymore.

25:43I think it is quite likely that the processes that we know about in these cells are involved in some mind to brain communication. And yes, maybe it has to do with the body keeping the score, with trauma having effects beyond the brain and being hard to treat with only the focus on the brain. Maybe the focus on the body in treatment of trauma relates to these cellular memories. I think that's a very possible, very, very reasonable theory. Yeah, regardless, subjectively, it feels that way. Like the feeling of, often the feeling of anxiety will be around the sort of diaphragm. And if you do allow that, you back off, allow that to come in, then it does eventually dissipate and then often might not return.

26:33or it could transform into excitement when you don't have this resistance or tension. And then eventually it becomes empty or it will disappear into no singular object, to use some sort of Buddhist terminology. Yeah, it can be hard to tell, you know, because our perspective, our introspective point of view is embodied, is located at least predominantly in the brain, it can be hard to tell is this a sensation in the brain or is this a sensation in the body. One example is muscle memory. We call it muscle memory because it feels as if your muscles were memorizing the piece on the piano by themselves.

27:18It feels as if your fingers are moving on their own. It feels like you're riding a bike, your muscles are doing it on its own. But it's not your muscles remembering it. It's still your brain. It just feels this certain way. So it might be that there are similar interoceptive parts of our brain that give us a sensation that it's this part of the body or that part of the body that is changing or that is memorizing something, while in fact it might be still just a part of the brain. But the other alternative is also possible. It's just hard to parse those things based on your own subjective feeling alone.

27:53definitely as you say it seems i think there might be something there actually um from my completely uh elementary education in biology and neuroscience but yeah it's interesting i often look at the eastern traditions and we've you know we've we've proven a lot of what has been talked about or theorized and practiced for thousands of years potentially up to 10 ,000 maybe even more and it's interesting that in for instance like traditional Chinese medicine they would they would go straight to a part of the body to diagnose a mental problem and as you're saying it I'm like oh actually that's the first time I've thought there might be something there actually you could they might have already looked with some form of intuition or awareness at those parts of the body that are related yeah i mean i would be very open to to diagnosing what's happening in the brain or what's happening to die to to being aware of what's happening in the brain through studying the body and vice versa being aware of what's happening in the body by studying the brain.

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29:14You know, we can probably tell based on the changes in our emotion and energy levels, there's probably a way to tell what goes on in the body as well. It's a reciprocal connection. They both interplay with each other. Yes, like biology recently, I don't know what's happening there. I thought it was a field that was relatively well understood, but it's just, there's just some incredible... There's so much to understand. and it you know we always make everything neat in all of the papers and all the textbooks it's all it all seems that you just you know you you you do an experiment and it works out exactly as it is on the page in reality everything in biology is just so messy all you can do is grasp at some straws of meeting in this constant torrent of chaos and try to cling on to some patterns but oh i i definitely don't get a sense that biology is well understood i get a sense that most of it us you know will never get a chance to even conceptualize what it means and thankfully we can pick out some patterns and just you know try to hold on to them as best we can that's my that's my feeling of working in the lab.

30:31Yeah, the more we find, the more we realize. Absolutely. Yeah, could not agree more. So how do you see this, this influence in like treatments for like neurological conditions or diseases, like rooted in mental or memory dysfunction? You mean how our studies might apply to neurological conditions? Yeah.

31:07Well, I think the deepest bottom line of our study is that patterns matter. Patterns matter on a surprisingly fine scale. They matter for surprising range of cells. And I think the more we know about our body, the more attuned we will be to the patterns of input. And that means patterns of input into our brain, patterns of input into our body. What's the most effective prevention of dementia? all the things that we already know. Social relationships, healthy lifestyle, walking in the park, fulfilling job, all of that we know makes you a healthier person. But we don't know exactly what that means.

32:09We don't know exactly what is a healthy diet. We don't know exactly what kinds of patterns of social relationships make you the happiest. And there's a possibility that we might find out. We might be able to tell exactly with what frequency should we be eating exactly what kind of food to get exactly what kind of emotion. I mean, at the moment, this is science fiction. At the moment, it seems crazy. But the fact that patterns matter on a finer timescale that we previously believed makes it possible that in the future, we will be able to construct our experience based on what we know about how those patterns convert into what outcomes.

32:52I know it's very general at the moment. I don't have a specific technique to save yourself from from Alzheimer's, but I think those techniques might exist and it's up to us to find them out. And that's true for the brain. It's equally true for the body in health and disease. In cancer, for example, our standard paradigm now is to kill cancer cells with chemotherapy. Chemotherapy is poison. Poison for cancer cells, also poison for other cells. The goal is to keep that level of poison at the level that would kill the cancer cells as much as the patient can tolerate for as long as possible until all the cancer is dead, and then you take that poison away.

33:38But it might be that there's a better pattern. Maybe we can achieve better killing of cancer cells by administering some non-obvious pattern of stimulation, by putting in that poison not for a long period of time, but administering it in bursts that are unevenly spaced to take advantage of the memory of those cancer cells. There's a sizable body of research that now looks at cancer drug resistance as a form of memory in cancer cells and asks how can we make those forget that they are resistant to that drug so that we can kill them more efficiently. So that's an example from a devastating disease, but the same could apply in less terrifying situations.

34:24Obesity, just exercise. We don't have a theory of how to time processes in our life. We do that arbitrarily. We do that based on overall impressions that more often is better, less often is good, or vice versa. But we never have a precise theory of how to arrange those events in time to maximize health, to maximize well-being. And I think our research points to that being possible. That's as much as I can tell. wow that's also incredibly exciting it is has anything been discovered about cells forgetting and how that might be done or is that also in in early research well so there's a couple of different ways i think about forgetting um could tradition and right now i'm talking about mental forgetting you know forgetting as a as a as the psychological phenomenon.

35:25It used to be thought of as almost a passive process that things happen when we memorize, but then they just passively gradually weigh and get forgotten. And that's true to some extent. There does seem to be more information processing happening at the front end of memory formation and the back end, the removal of the memory is sort of just this process that mills over every memory, regardless of what it is to some extent. But we now know that there is, for example, active forgetting, that some memories are preferentially erased when the brain decides that it needs to get rid of them. Some memories are more stable and don't just passively disappear.

36:09So you can control the process of memory formation at the level of forgetting. We understand now that forgetting is equally as important for memory as memorizing itself. you don't want to retain every piece of information that passes through your brain. It would be counterproductive. You want to generalize, you want to remove specifics and focus on the big picture. So forgetting is just as much a part of memory formation as the learning, as the front end. So is the same true for ourselves? To some extent, yes. we know that there are both passive and active processes in the removal of this cellular memory that we're studying.

36:53It will eventually just disappear, but there might be a way to accelerate the process. That is something that we're very interested in because if we can figure out a way to accelerate the disappearance of that cellular memory, well that might point to a way to, for example, clear your brain of addiction. Let's say addiction is a pathological memory that you don't want, you want to get rid of it. If there was a pharmacological way that you could tell the cell to accelerate your forgetting and administer it just to your cells that are responsible for that addiction, that would be a great medical intervention.

37:30So that's something that we're interested in. It's a work in progress, early days. I can't tell you much about it, but definitely something that we're interested in. And who knows? Again, we don't yet know exactly what role body memory plays in our body. We can only speculate about that. But there probably are some body memories that we don't want. Probably some that we want to occasionally get rid of. And accelerating that forgetting process would definitely be beneficial. So stay tuned. Yeah, that would be, I mean, the addiction that would be massive and also i assume could be applied to so many different issues particularly societal issues it's really of course the difficulty is to to forget that but not forget everything else that you remember in your brain you know it would it would probably be easy to just wipe all the contents of the entire brain but well we don't want that either full data wire full reset factory reset yeah factory reset exactly yeah yeah yeah that's kind of actually reminiscent to what we're currently doing with our cells.

38:30We're trying to achieve a factory reset, basically. But it's easier with individual cells than with the entire brain. Yeah, it's a little bit more nuanced at that scale. So I've heard you suggest that the brain is based on memory rather than the other way around. Could you elaborate on that perspective? Well,

38:56In the past, people thought of memory as something that you plug into. It's something that's external to your brain. It's almost an object that you place somewhere in the brain and there it sits. And when you access it, you reach into this object and you grab it. And you can take it from there and place it somewhere else. But it's not what memory is. It's not even just how it works. It's not what it is. Memory is not an external object to the brain. It's not a standalone object. It's not dissociable from whatever is memorizing it. If we're talking about the brain, well, a memory is how that brain changes in response to experience.

39:34It's all the combination of all the changes, instant changes that immediately disappear, long-term changes that take forever to clear off. All of those changes taken together, that is what memory is. You can't separate one memory from another, and you can't separate memory from what memorizes it, because you can't separate a change from what is changing. That's maybe the best, the easiest way to put it. So that's what I mean by the brain is memories. Every single action, every single activity that happens in the brain modifies it in some way, big or small, short or long. And all of that is memory.

40:11So given your findings on the mass-based learning effect, Do you see, would that also, would that apply to full-size brains as well, to all learning? That's the part that we do know. That's our starting point for this research. The mass-based learning effect is one of the most fundamental properties of memory that we know about. It seems to work regardless of what kind of memory this is, good or bad, or procedural memory or episodic memory, whether it forms in humans or in mice or sea slugs or even if you study entire student classrooms and measure their performance. No matter what you look at, if you have the same amount of training, if you administer it in one crammed go, you form an inferior memory to if you administer that same amount of training in spaced intervals.

41:12That's as rock-solid as anything could possibly be. It was established by Ebinghaus, Herman Ebinghaus, this German researcher from the 1800s who studied his own memory. He memorized these nonsense words and repeated them to himself in very specific patterns and measured how well he remembered them. His whole life was an experiment. And he established this spacing effect first. So that has been seen in brain systems, but never outside the brain. So really the news of our work was that actually that famous psychological effect that we all know and love actually cells have it too. Cells also follow the same rule if you give them experiences in the form of chemicals and if you observe their memory in the form of this glowing artificial protein that they produce.

42:04And if you do that they also form a superior memory more of that glowing protein for a longer time if you administer the chemical pulses in spaced intervals rather than cramming them all in one. So that was the big story of our study, that this rule is not a brain thing, it's a cell thing. How does that, is there a limit for the time interval or is there like an optimal amount? I assume you had to... Yeah, no, of course. That's a very astute question, because it can be infinite. If it's infinite, if the time extends forever, well, then you just have individual single events. It's not a repetition.

42:48A cell has to have some peak, some moment in time when it decides that repetition is most meaningful. If it's zero, well, then you're cramming everything in one go. If it's infinitely long, then you're just doing single events on different days. But there is some optimal, we call it ITI, intratrial interval, that produces the superior memory. And what's interesting is that we think that different kinds of signals, so different kinds of signals can induce the cellular memory, produce this glowing protein that we're looking at. We can input different kinds of chemicals, all of them emulate signals from other cells, but there are different types of signals and so we can emulate them all independently.

43:35And all of them produce some response on our glowing protein produced this memory. But it appears that different signals are tuned to a different time interval. So some of them produce the most superior memory when the time interval is 10 minutes. Some of them produce it best when the time interval is 20 minutes. We suspect that another one produces it at much shorter time intervals. So we think that real life cellular experience is a combination of all those timelines because the cell is not just receiving a single signal at a time. It's constantly listening into thousands of different signals.

44:13And for each of those signals, there's some optimal timing when the cell responds to it maximally. And so its overall response is some averaged out response to all of these different timelines. That's how it analyzes the patterns. By combining all those patterns of all those chemicals into single response, it abstracts all of this timing information that is tuned to into a particular physiological state. So we think that Having those different molecules that are tuned to different time intervals, it is a way for a cell to analyze complex patterns of information.

44:54in a popular sort of contemplative research approach in neuroscience sort of where the eastern traditions are meeting neuroscience i guess you could say is that the self is a construct potentially of the brain and we spoke to Shamil Shandaria about the Bayesian brain hypotheses. And yeah, as you're probably familiar with the free energy principle and how the brain appears to construct reality. And we are now applying those models to AI and machine learning algorithms. So for anyone that doesn't know, basically, there's computational stacking within the brain that your brain is trying to predict reality just because it's computationally very explosive.

45:55there's a lot of data coming in from the senses and now potentially data coming in from the cells and your brain needs to take the past information and predict the future because there's just not enough bandwidth in the brain so yeah is it possible that what we call the self is also a construct of or an accumulation of kind of like accumulated memory, even cell memory. I think it's very reasonable to say that. I think that what you described as prediction, this top-down flow of information, that our brain conceptualizing this information that's coming from the senses, where does this top-down flow of information come from?

46:55Where do those predictions come from? They come from memory. So I use this in my book and in class, I use visual illusions. Well, for example, there's this one where you can see either a young woman turned away or an old woman that's kind of in profile. It's a clever picture, but you can only see one at a time. You can't see them both at the same time, Even though you understand exactly how it works, you see where all the lines go, no matter how hard you try, you can't see both pictures at the same time. Another one is like two faces and a vase in the middle. Very simple. Nothing's mysterious about this, but your perception can only focus on one or the other at that time.

47:37So that's the prediction. We like to believe that we just passively take in senses, analyze them, and come to a conclusion. But we're actually actively participating in our perception. where we're actively picking out things that we want to be perceiving. To perceive something, you have to decide that I'm either going to be looking at the faces or I'm going to be looking at the vase. You have to make that decision and then that's when you perceive it. But that decision originates from memory. You have to see faces at some point in your life. You have to see vases at some point to memorize what they look like, to carry that image in your mind and to pick it out from this chaos of sensory experience.

48:16So in that sense, yes absolutely, our self is a layering of such memories. It is a layering of predictions that predict predictions. It's overarching predictions that predict smaller predictions that predict even more specific predictions that predict even more specific predictions that predict what we will receive through our senses in real life. It's a nested hierarchy of levels of prediction, all of which are embedded in the memory of those cells that carry those signals around. So when we talk about cellular memories, that includes the memory of neurons. Yes, all those neurons are cells. Neurons are not different from any of those other cells.

49:01So definitely their cellular memories contribute to those nested levels of prediction that form who we are. Are other cells of the body also involved in those nested levels of prediction? Maybe, maybe. We don't know about that yet. That's not part of the free energy principle by Friston and Clark, but I can easily see that they are involved in those levels and they participate in either supplying the information into the brain, as we discussed, is possible for trauma, or even maybe are participating in predicting that information and in producing that top-down flow of information that predicts ongoing behavior.

49:44One good candidate could be glial cells that are inside the brain but are not neurons. They are well positioned to be non-neural cells that could retain some imprint of experience and could control the behavior of neurons responding to ongoing information. And so, yeah, easily the state of a glial cell could contribute to our sense of self. I wouldn't be surprised by that. Wow. There would be big updates with the model of our understanding of the world if that was the case. And yeah, as we said earlier, I think the more we discover, the more we realize we don't know. Of course, the more we realize we still have to learn.

50:36I mean, we're now at the point when we are beginning to, well, I would say what AI now does is maybe not emulates, but it is at least inspired by the electrical behavior of neurons. But this electrical behavior, those electrical signals that are passing between neurons, that is only one aspect of what they do. That is only one aspect of their physiology. There are thousands of other aspects of thousands of other processes that are happening in neurons that are not electrical pulses. And so I think that as we progress in technology and artificial intelligence, we will start incorporating more and more of those other neuronal biological processes and cellular processes into our models of intelligence.

51:29Right now it's all electrical pulses interacting with each other. But if we incorporate more cell-like behaviors, then our AI might become more biorealistic. It might have a more realistic memory, for example. It might respond to patterns of input more like a human would. It would learn from them in similar ways. It would modify itself, would be more flexible, maybe. so I would say that if I'm if I want to predict the the direction in which AI will go I think it will gradually become more and more similar to to the body and to cells specifically yeah and then you've also got like Penrose and Hammer-Off over there trying oh yeah with the microtubules yeah potential fundamental consciousness it's just yeah it's science has just become so interesting recently um i've also been following yeah michael levin professor michael levin's work pretty yeah pretty extensively and it seems like there would be a convergence and that it's about to or is already connecting pretty well with your work he's looking at bioelectricity with pattern memories for development and regeneration.

52:56Is that something that you have been looking into as well? I'm very inspired by Mike Levin's work. He's definitely a major role model for me. I look up to him and he's given me good advice. And we've shared our studies. We've sent them our cell lines, hopefully. they will do something interesting with them as well. Yeah, I think our biggest point of overlap with Mike Levin is that we both think of these cellular processes like memory, like cognition, not metaphorically, but literally. And that's a big part of our message to the world that when we're saying cellular memory or cellular cognition, as we already discussed, we're not using these words in quotation marks.

53:47We mean them literally. We mean that the more advanced forms of cognition and memory are built upon these molecular tools that have been around since before there were brains and animals and humans and anything like that. So all of these processes have deeper evolutionary roots than we like to believe. On that point, we truly agree. And I think that our work is supportive of each other's in that respect. As far as bioelectricity, well, I mean, anything that passes through a neuron or spikes is bioelectricity. So in a sense, I am studying bioelectricity. We haven't touched regeneration yet. So I would say that Mike Levin's work is more on the body side.

54:37We, because we're coming from the brains, we're more still on the neuroscience side, but we're working on very, very similar problems and definitely like-minded researchers. Amazing. Could you briefly describe what his fundamental findings have been that have surprised you? What his fundamental findings are? Well, I mean, there's a lot of research that comes out of Mike Levin's lab. A lot of it is theoretical. I would say his most fundamental findings are that... cells are not driven exclusively, and maybe not primarily, by their genetic constructions. But instead, their life is rich in communications with other cells in the body, and that communication is what sculpts our organism as it is.

55:41So we used to believe that everything in our body is given to us in those 20 ,000 genes in the sperm and an egg, and everything else is just this program unfolding in time, all those instructions unfolding in time. But actually, through communication channels such as bioelectricity that used to be ignored, but now turned out to be information-rich, cells can organize complex modes of communication that supplement and really build upon those genetic instructions given to us in evolution. So the way that it used to be thought of, we have genes, that sets up the body, and then on top of that, we have the brain, and that learns from experience.

56:24But what Mike Levin's work says is that all cells learn from experience, and that's most of what the organismal biology is. The very setup of our body, our very multicellularity, is cells learning from experience and organizing this body through communication with each other. So I think that's the deepest philosophical message of Mike Levin's work. And what was so surprising for me? Well, I thought that electricity was exclusive to neurons and that whatever happens in outside cells, that maybe affects their state, but it's not something that is information rich. Basically, I think in both his work and in our work, I'm surprised by how smart non-brain cells really are.

57:12We used to think of them as dumb, but actually they can be, I should say, almost as smart as neurons. Neurons maybe are a little bit smarter. Neurons operate on millisecond timescales that other cells maybe don't quite reach. Although, what else? We'll see. Just to circle back to an earlier question. Is that something that you think about much in terms of consciousness being fundamental? if cells are storing memory. I mean, the next question would be, where is that stored? And then at the same time, we have all the consciousness research happening and seemingly some evidence coming from Penrose and Amarov that at least the microtubules are heavily connected to consciousness.

58:07in the i think if we have uh anesthesia my understanding is they they modified an fmri scanner and i don't understand this well enough to be quoted on it but that they could see that the microtubules were functioning less or um and on the other side of that subjective conscious subjectively consciousness was being shut off so yeah is that something that you've put much thought behind, or is that a little bit further down the path as well? No, I think about consciousness a lot, and I'm aware of the microtubular hypotheses, theories. Since I completely understand them, I'm also a little bit scared of all the microtubule people because they are very aggressive for some reason.

58:55I don't know if people believe that consciousness is in microtubules. God forbid you say something against that. Oh, my God. So what I don't understand about those microtubular theories is, from what I understand, most of them are based on the fact that microtubules have quantum properties. they have many degrees of freedom and they can store their state, they can form memory, you can store memory in a microtubule, and that they are important for the functioning of the brain. I think all those three things are completely true, I don't disagree with any of them, But I don't know if that necessarily leads me to believe that microtubules carry consciousness.

59:51I think it's a big leap from saying that consciousness involves some quantum scale processes to the content of our consciousness is determined by quantum mechanics. I think that's a big leap. Everything involves quantum processes. Any chemical reaction involves quantum processes. So simply saying that there are some quanta flying around, that the quanta are involved, is not really saying anything. I think what is attractive about quantum mechanics with regards to consciousness, and I think that's where Penrose originally comes from, is this idea of a collapse. Of the wave function collapse. Because quantum mechanics tells us that particles exist in this ambiguous state.

1:00:37They're neither here nor there. They're neither a particle nor a wave. They are spread, their probability of existence is spread around this, you know, electron's probability is spread around the nucleus of an atom. And when you try to detect it, when you try to place a finger in it, when you try to put it into a machine that detects it, that's when it collapses into here or there. And so it seems that a similar thing is happening in our mind. It seems that interpretations of reality exist in this ambiguous state, and when you try to understand something, when you try to become aware of something, you are searching for ways to collapse that ambiguity into specific states, and it might resolve one way, or it might resolve another way, and that's when you become conscious of something.

1:01:29I think that is a good metaphor. I think it's an analogy that makes sense in the same way as a wave function collapses into different states of the particle, in the same way the network of our brain, the network activity of our brain can collapse into specific states of that brain. And in that sense, sure, it's similar, but I don't think it necessarily means that wave function collapse is at the heart of the collapse of this neuronal network into specific states. So I think that's why quantum mechanics is so attractive as an explanation for consciousness. So I simply don't see a need to invoke quantum mechanics to explain conscious processes.

1:02:11This need might arise in the future and I'm willing to accept that there's something about wave function collapse that is critical to the content of consciousness that I don't yet understand. But I don't yet know what that something would be. So I don't see a necessity for invoking quantum explanations in consciousness. What puzzles me about microtubules in memory, if you know memory really is stored in microtubules, that I don't understand how we explain, for example, the effect of protein synthesis inhibitors on reconsolidation of memory. So long-term memories are known to become malleable when you think of them.

1:03:04When you recall a memory, it turns into this temporarily malleable state. And during that state, you can disrupt that memory. if you give a protein synthesis inhibitor. So if you give a person that protein synthesis inhibitor, well, you shouldn't be giving it to a person because they're toxic. Let's say a rat. If you give a rat that protein synthesis inhibitor without it thinking about the memory, just at a random time, nothing will happen to that memory. But if you give it while it's thinking about that memory, as it's actively recalling it, and then you give that protein synthesis inhibitor, and it will forget that memory.

1:03:40So in that moment, it becomes flexible, and you can disrupt it by blocking the synthesis of proteins. If the memory is stored in a microtubule, why does that happen? A microtubule is already there. They don't need to get resynthesized at that time frame of a couple of hours when you would administer that drug. So that to me is the biggest question mark in memories being stored in microtubules. But you know, memories are not stored in any particular place. Memory is a stable state of a cell, of a molecule, of a neural pathway. For whatever reason, the cell has left its configuration where it was before and now it's stabilized itself into a new configuration.

1:04:27Where is this configuration stored? It's not stored in any particular molecule or any particular gene. It's stored in the configuration as a whole. Everything is different and nothing specifically. That's true for the cell. That's true for the brain. That's true for any vehicle of memory. And is a microtubule part of that configuration? 100%. I don't doubt that. I'm sure that microtubules store some of the changes that happen to brain cells or to other cells during experience. And that those changes are meaningful to what that cell does in the future. I just don't see a reason to privilege microtubules in such a way as some people do it.

1:05:09There's lots of other molecules in the cell that I love equally as much, and I think are equally wonderful and could store many different aspects of experience in equally sophisticated ways. And it looks like there's already enough to discover in the near future right in front of you. We probably don't potentially need to make that leap, but I agree. I see how they might start to make that leap just from, I mean, consciousness has been struggled with for a long time. And now we have quantum mechanics in some ways has also been struggled with for a long time. Yeah, it's attractive to connect those two mysterious things.

1:05:50And I think it also somehow subliminally, it elevates you. You know, we want to be mysterious. We don't want to be just dull electrical signals. We want to be, you know, another dimension of reality. And I think it's just an attractive thing, but I don't know. I'm okay with being just electrical signals. Yeah. I mean, it's already mind blowing. Yeah. It's complicated enough. It's not insulting to me.

1:06:21So yeah, we mentioned earlier your, your incredible book. I'll repeat it again but it was one of the most beautiful book covers I've ever seen that's upcoming in October I think you said so yeah, could you tell us a little bit about that the title that you've landed on and what it's about so the book is called One Hand Clapping, Unraveling the Mystery of the Human Mind and One Hand Clapping as you I'm sure know refers to a Zen koan a koan in Zen Buddhism is a riddle it's an unanswerable question. It's a riddle without a solution. And so in this book, in the same way as this koan asks a seemingly unanswerable question of how could a single hand produce the sound of clapping, in the same way we ask a question, I ask the question of how could a human mind exist in this world of atoms and molecules?

1:07:22You know, I had a student come to my office a few weeks ago and i think she put she asked me a question and i was like this is what my book is about i've been trying to phrase it for for years now and you've just captured it in one question she asked you know if life is all atoms and molecules and if we are just animals, then why does it feel so meaningful to be myself? That's really what the book is about. If we're in a science class, it seems that the world is made of the same stuff. Everything is made out of the same atoms, molecules, and chemically speaking, I'm pretty much equivalent to a mushroom, and even my neural organization is not that different from a mouse or a fruit fly.

1:08:14And yet it feels fundamentally different to be me. It feels different to be me versus all the other humans. You know, I have my own consciousness and it feels very different from looking at everybody else in third person. In the same way, it feels different to be a human compared to all those other animals. Even though science tells us that there is no better or worse evolved, that we are all evolved in the same way, we're equally developed, and for some reason it feels different to be a human. It feels different to be alive versus being not alive, even though we're made out of the same atoms.

1:08:55So where does this specialness come from? Where does this meaningfulness come from? And so it really is the same story. It is the same case of specialness. that we can trace from the very origin of life, through the birth of the cell, through the appearance of animals, and then vertebrates, and then mammals, and then primates, and then humans, and then our own self. It is the same common thread of I am special compared to everybody else. And so in the book I try to understand what does it mean to be me from the perspective of the world around me? What does it mean to be human, a conscious individual here now, from the perspective of the entire universe, life on earth as a whole?

1:09:44That's what the book is about. It sounds incredible. And I look forward to getting a copy. It's already out in Russia, I believe. How was it perceived there? Yeah, it did really well in Russia. So it was published a few years ago and won multiple awards and still selling very well. I would say that the Russian version is much thicker than the English version. It's a lot denser. I think that Russian people have more tolerance for longer form content and it took me a while to not even translate or or even rewrite, but to rethink the entire book from the perspective of an English-speaking audience.

1:10:27It wasn't really anything specific. It was a wonderfully interesting experience of just re-experiencing it in a different language. But yeah, it's still recognized and still sold in Russia, and I'm proud of that. Yeah, amazing. Amazing. Great work. And if anyone wants to find out more about you or your work, where's best to find you? Yeah, you can follow me on social media, Nico underscore Kokoschkin on X. You can go to my website, Nikolai Kokoschkin.com, or hold the links to all my writing, my book, my press appearances, and everything else that you might want to know about me. Everything's on the website.

1:11:19so I would say either one of the two Twitter or my website Amazing and we'll pop the notes below. Thank you so much. I really really enjoyed the conversation and yeah keep going I think you're doing incredible work. Thank you Josh it was a lot of fun. Thanks so much. Excited to see what happens in the future for you I'll keep you posted. Thank you so much for listening to the episode if you enjoyed it please if you could give us a like, a subscribe and hit the notification bell that would really help us out or just share this episode with a friend, share the course with a friend. Anything would go such a long way.

1:11:55Thank you so much and I hope to see you soon.

From the publisher

Can cells outside the brain learn, remember, and make decisions?

In this episode, neuroscientist Dr. Nikolay Kukushkin shares groundbreaking research that shows even non-neuronal cells can recognize patterns, count, and store information in ways strikingly similar to brain cells.

We explore:

  • Why memory may not be limited to the brain

  • What sea slugs can teach us about human cognition

  • How prediction and perception shape our sense of self

  • The parallels between AI and biological intelligence

  • Whether trauma could be “stored” in cells outside the nervous system

Dr. Kukushkin's work suggests we rethink intelligence, not as something exclusive to the brain, but as a fundamental property of life.

FitMind Neuroscience-Based App: http://bit.ly/afitmind

Website: www.fitmind.org

 

SHOW NOTES

0:00 | Intro to Nikolay Kukushkin, PhD

5:10 | Memory in Seaslugs

10:25 | Cells Can Recognize Patterns

20:28 | Memory Defined

23:02 | Do Cells Store Trauma?

30:40 | Treatment for Neurological Conditions

38:40 | Brain & Memory Connection

42:25 | Optimal Interval for Superior Memory

44:52 | Layering of Predictions

50:35 | AI Inspired by Neuronal Behavior

52:27 | Cellular Cognition & Memory

54:47 | Intelligence of Non-Brain Cells

58:38 | Consciousness in Microtubules

1:06:15 | Where to Follow His Work

Website: https://www.nikolaykukushkin.com

One Hand Clapping Book: https://www.nikolaykukushkin.com/press-1

Follow on X: https://x.com/niko_kukushkin

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