In short
Podcast Episode Notes: DeepSeek’s V4 Coding Leap, Strava’s IPO Move & Silicon Valley’s Aging Craze | Jan 9, 2026
Podcast Overview Podcast Title: The Information's TITV Episode Title: DeepSeek’s V4 Coding Leap, Strava’s IPO Move & Silicon Valley’s Aging Craze Air Date: January 9, 2026 Hosts: Akash Pasricha, Jing Yang (Asia Bureau Chief), Cory Weinberg (Deputy Bureau Chief of Finance), Dan Shipper (CEO at Every), Zach Reitano (CEO of Ro), Jemima McEvoy (reporter), Martin Peers, Meredith Mazzilli (Editors)
Episode Summary This episode covers significant developments in the tech industry, focusing on AI advancements, IPO movements, and trends in health tech. Key discussions include DeepSeek's upcoming V4 model, Strava's secret IPO filing, Lambda's funding round, the intersection of AI and healthcare, and the growing fascination in Silicon Valley with biological age measurement.
---
Key Segments
- DeepSeek's V4 Model
- DeepSeek is launching its V4 AI model, expected to have superior coding capabilities compared to competitors like Anthropic and OpenAI.
- Differences between models:
- The V3 model focused on general-purpose tasks.
- The R1 model was geared towards reasoning and logical task sequences.
- DeepSeek's influence: Their open-source approach has sparked increased competition in the Chinese AI model development space.
- Strava's IPO Move
- Strava has filed confidentially for an IPO, revealing:
- Current revenue between $400M - $500M.
- An impressive 50% annual growth rate, marking it as one of the fastest-growing consumer apps.
- Concerns about sustainability and potential acquisition interests from larger health and fitness companies.
- Lambda's $350M Funding Round
- Lambda, an NVIDIA-backed cloud provider, is seeking to raise $350 million ahead of its IPO.
- Challenges: Questions linger about the long-term sustainability and business model viability of cloud providers in the AI boom.
- AI and Media
- Dan Shipper, CEO of Every, discusses the blending of media and AI application.
- Every offers a subscription model combining AI tools, training, and media insights.
- Shipper emphasizes the importance of trust in AI applications and how user experiences can significantly affect adoption.
- Health Tech Innovations
- Zach Reitano, CEO of Ro, shares insights into new GLP-1 pills for weight loss and the potential of AI in healthcare.
- Discussion on the societal implications of healthcare technology and the integration of AI into patient management systems.
- The Fascination with Biological Age
- Jemima McEvoy covers the surge in companies offering biological age assessments.
- Market growth: Around $800M raised by various companies in this sector.
- The lack of consensus on how to measure biological age leads to varying results and potential consumer confusion.
- Highlights the extreme measures some individuals will take to improve their perceived age and health.
- E-commerce and AI
- Editors Martin Peers and Meredith Mazzilli discuss the potential of AI in e-commerce, particularly focusing on Amazon's advancements.
- Challenges with AI shopping tools and the importance of consumer trust and experience in purchasing decisions.
---
Key Takeaways
- AI Development: Competitive landscape intensifying with new AI models and applications emerging rapidly.
- Health Tech: Growing interest in biological age and weight management solutions, but also caution around accuracy and marketing tactics.
- E-commerce Evolution: Amazon's approach to AI in shopping could redefine consumer behavior, but reliance on AI tools is still in its infancy with many challenges to overcome.
- Trust in Technology: Both in AI and health tech, establishing trust is crucial for user adoption and engagement.
---
Links to Articles Discussed
- [DeepSeek's V4 Launch](https://www.theinformation.com/articles/deepseek-release-next-flagship-ai-model-strong-coding-ability)
- [Strava Confidential IPO Filing](https://www.theinformation.com/articles/strava-filed-confidentially-ipo-hired-goldman-sachs)
- [Lambda's $350M Fundraising](https://www.theinformation.com/articles/nvidia-backed-cloud-provider-lambda-talks-raise-350-million-ahead-ipo)
- [Biological Age Testing](https://www.theinformation.com/articles/silicon-valley-obsessed-biological-age-tests-despite-dubious-science)
---
Closing Remarks The episode closes with an invitation for viewers to tune in for future discussions, highlighting the ongoing evolution in technology, health, and consumer behavior as shaped by AI advancements.
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VODeepSeek's Upcoming AI Model Release
0:46 to 1:30
Discussion on DeepSeek's upcoming AI model V4 and its expected features.
“We have a great lineup of guests for you.”
Comparing DeepSeek Models
1:31 to 2:28
Exploration of the differences between DeepSeek's V3 and R1 models.
“So what do we know about this new model and the DeepSeq news?”
DeepSeek's Position in AI Competition
2:29 to 4:25
Analysis of DeepSeek's role in the open-source AI landscape and competition dynamics.
“So, V3 was launched in December 24, as I mentioned, and that model was already very good.”
Strava's IPO Filing Discussion
4:26 to 5:59
Corey Weinberg discusses Strava's recent IPO filing and business growth.
“all rushed, raced to release their own open source model offerings.”
Analyzing Strava's Market Potential
6:00 to 8:29
Insights on Strava's performance, growth prospects, and market comparisons.
“Strava has filed confidentially to go public.”
Lambda and NeoCloud Developments
8:30 to 11:15
Discussion on Lambda's pre-IPO plans and its position in the cloud sector.
“And, you know, there are run clubs all over the place.”
Investment Strategies in AI Startups
11:16 to 14:02
Corey Weinberg elaborates on financing structures and trends in AI investments.
“Lambda is a bit, seemingly, its little cousin.”
Investors and Financial Instruments
14:02 to 14:34
Learn about the changing interests of investors and new financial instruments.
“that were interested in getting a piece of companies before they went public.”
Exploring Every: AI, Apps, and Training
15:01 to 17:46
Discover the three pillars of Every: ideas, apps, and training.
“Tell us about everything that Every is, because there's a lot going on over there.”
The Role of Agents in AI
17:46 to 19:18
Understand the significance of agents in AI and their impact on workflows.
“starting, which I think is very different from a superhuman or a Gmail where they have to sort of split the difference between AI early adopters and everybody else.”
Show all 23 chapters
Trust and Effectiveness in AI Products
19:18 to 21:30
Learn how trust in AI products is build through effective performance.
“And it has not quite gotten to that level for the rest of knowledge work.”
The Intersection of Media and Software
21:30 to 23:31
Explore how the lines between media and software companies are blurring.
“You also are running a media company, which in the era of AI is kind of interesting.”
Zach Raytano on Health Tech Innovations
24:11 to 28:01
Discuss the impact of new health tech innovations like the Wigovi pill.
“But I mean, long term, I mean, the injectables, they'll probably go away, right?”
Engaging Patients for Actionable Health Data
28:01 to 29:54
Learn how patient engagement can transform unstructured health data into actionable insights.
“okay, all of that data, how do we make it actionable?”
AI in Healthcare: Accountability and Speed
29:55 to 32:04
Explore the implications of AI in healthcare, including accountability and efficiency improvements.
“You know, there is a question about is it the platform?”
The Peptide Craze and Patient Empowerment
32:04 to 33:52
Discuss the rising trend of peptides and how patients are taking charge of their health.
“You know, everyone is talking about— Peptides and microdosing, right?”
Amazon's Potential in AI E-commerce
34:29 to 36:25
Analyzing predictions about Amazon's role in AI-enhanced e-commerce this year.
“And just to set the scene here for people, Meredith and Martin sit next to each other.”
Challenges Facing AI Shopping Agents
36:26 to 38:04
Investigate the limitations and challenges of AI agents in the shopping experience.
“Okay, so Martin, Meredith thinks, she agrees with me actually, this is going to be the year.”
The Future of AI in Retail
38:05 to 42:00
Discussion of the future of AI in retail and the skepticism surrounding current announcements.
“So like what OpenAI is trying to do is team up directly, which has very little to do with AI, just kind of plug in directly with retailers, with payments firms, with this AI layer over it.”
Skepticism in Tech Announcements
42:00 to 43:30
The discussion centers around the constant stream of tech announcements and the skepticism surrounding their viability.
“I mean, Akash, you have to remember we're in the period right now where companies are announcing things constantly.”
Biological Age Discussion Introduction
43:30 to 44:40
The hosts introduce a segment on health tech focusing on biological age and its complexities.
“That is Martin and Meredith, two of our most fun editors here at The Information for this week's editor's cut.”
The Landscape of Biological Age Testing
44:40 to 48:20
Jemima discusses the different companies involved in biological age testing and the complexities surrounding their claims.
“we were worried that the results wouldn't come back in time.”
Public Interest in Aging Solutions
48:20 to 50:35
The conversation highlights extreme cases of individuals seeking solutions for aging, emphasizing the persistent interest in biological age.
“particularly accurate in the first place, why would it be valuable to check over time also?”
Transcript
Automatic transcript. May contain errors.0:13Welcome, everyone, to the information's TI-TV. My name is Akash Pasricha. It is Friday, January 9th. We have a busy show to close out the week. First up, the information published exclusive reporting that DeepSeek is just weeks away from releasing its new flagship AI model. We will discuss the news with our Asia Bureau Chief. We're also exclusively reporting that Strava has filed confidentially for an IPO. and NVIDIA-backed cloud provider Lambda is in talks to raise$350 million ahead of its IPO. We will break down both of those stories. We have a great lineup of guests for you. Dan Shipper, CEO at Every, will join the program to talk AI and media.
0:55And we are also sitting down with the Zach Raytano, CEO of ROW, who will talk about the company's new GLP-1 pill launched with Novo Nordisk. And it is Friday, so it's time for another edition of The Editor's Cut, and our weekend reporter will wrap the show talking about Silicon Valley's latest obsession, learning your biological age. It is a jam-packed show, and so let's get right on into things. The information published exclusive reporting that DeepSeek is expected to launch its next-gen AI model in the coming weeks. Joining me now with the details is our Asia Bureau Chief, Jingyang Jing. Welcome back to the show.
1:32It's great to have you here. Thank you, Akech. I'll be back in the new year. So what do we know about this new model and the DeepSeq news? Yeah, so the new model is going to be called V4, which is a successor to V3, which was launched in December 2024. And this new model features very strong coding capabilities. DeepSeq employees conducted testings based on their own internal benchmark, and those testings show that V4 outperforms both, you know, anthropic and open-ass models in coding. Obviously, the proof is going to be in the pudding. We won't know if it really outperforms until, you know, we see what it is.
2:20Well, I mean, the first step is getting it out there, so that's the first step here. Talk to me about what is the difference between the V series models and then the R1 model that I know has gotten a lot of attention at DeepSeek. Yeah. So, V3 was launched in December 24, as I mentioned, and that model was already very good. It's a large language model, general purpose model, what we call, that already put the company on the map in the global AI community. And the R1, the R series, which we only had one generation so far is what we call a reasoning model. Basically, it can perform like it takes time to think and then perform a series of tasks in a logical sequence.
3:08And that was the model, by the way, which was released in January 2005, about a year ago, that, you know, shocked, that sent shock waves from Silicon Valley to Wall Street. That was what we now call the DeepSeek moment. Okay. I wonder how you think about DeepSeek's model releases in the context of its position in the AI race. Is it a similar sort of arms race as we see here in North America with respect to just trying to get the best model? I mean, is it working on anything broader than the models and applications that people can use? so DeepSeek as you know is like a big champion on for open source and then all of their models have been open source and when R1 was after VC V3 and excuse me after V3 and R1's releases it sort of started in China this intensified this competition and then really like raised the awareness of open source among the Chinese L1 developer community.
4:16And throughout 2025, we see companies from giants like Alibaba and Baidu to startups like Zhipu, Minimax, and Moonshot all rushed, raced to release their own open source model offerings. And however, in the same time, DeepSeek simply sort of has gone quiet. But, you know, if they do release v4, like we write about in the next few weeks around mid-February, that will be their first major model release after they became a global sensation. And then in the U.S., as we know, Lama, developed by Meta, was, you know, a big champion, is a big champion of open source, where I think most of the other model developers in the U.S.
5:04sort of have taken the closed source approach. And then the DeepSeek moment last year also sort of incentivized some discussions over, you know, if we actually should, in the US, if we should actually, you know, do more open source models as well. And right now, we haven't seen that really happening at a larger scale. And then DeepSeek plus, you know, the other Chinese model developers that have taken the open source route following DeepSeek's lead. has in the past year really sort of made China, Chinese open source model really the most used by number of tokens around the world when it comes to just, you know, open source models on their own.
5:52Great. Well, it is a story that we are following closely. Jing, I want to thank you for coming on. That is Jing Yang, our Asia Bureau Chief, here at The Information. Okay. Strava has filed confidentially to go public. That is according to a new exclusive story from The Information. I want to bring on our Deputy Bureau Chief of Finance, Corey Weinberg, to talk about the state of that business. Corey, welcome back to the show. It's great to have you here. Hey, Akash. Good morning. Is that the LA light that I got you for Christmas behind you? Yeah, I mean, it is, Akash, and I loved it. and to bring our listeners and viewers up to speed.
6:31The information does have a Secret Santa celebration internally, and I guess Akash was mine. I was very thoughtful that the LA Dodgers won this year, and I was also a little upset because, of course, they beat my beloved Blue Jays, but I'm a good sport, and so are you. You put it up, so thanks for doing that. I appreciate it. Totally, totally. the good good signpost for la all right so let's talk about strava which uh maybe you're a power user maybe you're not maybe we'll get there i don't know but you reported that the company has filed confidentially to go public this is a business that we have been writing about for a little while at the information what do we know about the state of that business yes i think Strava is going to surprise people when it's S1 comes out in a couple of months.
7:26The business has had one of those unusual stories where it's been around forever. You know, this company was founded, you know, when I was still in high school. So quite a while ago. And, you know, it has picked up growth as of late. So its revenue is between$400 million and$500 million was what we learned. But it's growing really quickly. It's growing over 50 % a year, which would make it the fastest growing or one of the fastest growing consumer apps on the public markets, should it go public. So that should be interesting to at least some investors. I guess it's kind of interesting with consumer apps.
8:11I mean, 50 % growth is staggering for any company. But I guess the risk with consumer is that if it's in, it's in. And, you know, he could have a good year. But then if it falls out of favor, then we don't know what's going to happen. Yeah, that's exactly. I mean, that's how I would think about the bear case as well. I mean, we'll see once we actually see more fully what the numbers in the story look like. But, yeah, it could be a fad. But right now it's in. And, you know, there are run clubs all over the place. You know, I just moved to L.A. Maybe I'll join a run club. but but you know it has like a decent sort of it's in with the fads right now people like running that's helped it grow beyond just cycling which was kind of its original use case so but you're right it could become not trendy very who do you think would be a good public comp for Strava out there I think the one that I've heard is Duolingo just in terms of subscription business for, you know, that is sort of making money off of people's, you know, sort of hobbies or side quests, so to speak.
9:23So that's one that's sort of come up in my reporting so far. And I think Martin, yours, our colleague, shouted that out last night as well. Well, and so one of the other things I've been thinking about is you talked in the story about, you know, how, sorry, getting a stroke. We got some noises here in the office, folks, but we're still going on with things. You had this piece in the story about, you know, the company being profitable. And we also wrote a weekend profile about the company a little while ago. And look, I mean, this is a business that I could have seen getting acquired potentially a couple years ago, just given the product suite that it has.
10:06Is this all just financial discipline that it's been able to acquire other businesses? Or what do you chuck that up to? Yeah, we don't know much about sort of whether there's been explicit M &A conversations. Obviously, there are larger companies that care about fitness and health that you would think would be logical acquirers. Apple, Garmin you've obviously seen private companies like Aura and you wrote about Whoop sort of take off on more of the hardware side so I don't know, I think it's logical to say this company is still pretty small, we called that out in the story, that revenue that top line revenue between$400 million and$500 million, that's not huge for a public company but we'll see we'll see how it trades after it goes public if it doesn't do well, I think it'll definitely get bought Okay, so let's talk about another story that you published this week.
11:02You reported, you had some new reporting about Lambda, the NeoCloud company. Tell us about what you learned there. Oh, NeoCloud. It's getting interesting. About this time last year, we were all gearing up for the CoreWeave, or maybe not all of us, but I was gearing up for the CoreWeave IPO, which happened in March last year. Lambda is a bit, seemingly, its little cousin. It has a very similar business in that they're trying to become some of the next big cloud providers, but their key tentpole is access to NVIDIA chips. NVIDIA is both an investor and a customer, which is a similar dynamic to CoreWeave, and they're trying to go public.
11:46These businesses need a ton of cash. They have debt. And before it goes public, what we wrote yesterday is it's trying to raise at least$350 million in what's known as a pre-IPO convert, a convertible note. And so that we think is interesting and definitely previews an IPO. I got to be honest, Corey, it's kind of funny. You are seemingly the only person I know that gets more excited about the NeoCloud sector than about Strava. I thought Strava was the more interesting business, but I guess NeoClouds are like, I mean, they are very much in this moment. They're harder to unpack or they're more controversial maybe.
12:30Strava is, it is what it is. I don't know. It's a consumer app that people use and it makes money. Neocloud always generate a lot more conversation because people don't know what to make of them. They are more interesting and weirder kind of financial animals. Like I said, they have debt. They all grow really fast. You know, Lambda is growing sales about 80%. But I think the question with them is like, what's their IP? What is this company? You know, sort of doesn't have a lasting business strategy beyond just being able to capture the AI boom. Now, you had this line in the story that I want to read.
13:10You said the terms of the new financing would pressure the company to list publicly the deal, which is structured as convertible notes, would force Lambda to award participating investors millions of dollars of additional equity or cash interest payments if it doesn't go public within a year. I want you to explain that a little bit to us and broadly the point I'm trying to get at is you know these complexities in deal terms I mean is that becoming more common in this moment in AI talk a little bit about that it it predates that a bit I would would take it back about a decade now it really these kind of pre-IPO you know structured rounds became much more popular when there became kind of a bigger rush of capital into the private markets.
14:01There became a deeper pool of investors that were interested in getting a piece of companies before they went public. And an instrument, a financial instrument like this, it's designed to protect investors' potential downside as well as giving them a piece of, you know, a potential upside rocket ship. And And they're meant, you know, they're designed to be raised fairly quickly. And so it removes some of the haggling over something like a valuation. Great. Well, Corey, I want to thank you for coming on. That is Corey Weinberg, our Deputy Bureau Chief of Finance here at The Information. Okay. AI has seeded a whole new generation of entrepreneurs that are finding ways to reinvent old business models and also rethink how we use everyday applications.
14:50Dan Shipper is one of those entrepreneurs. His company, Every, is part media company, part AI app company. I want to bring him on to talk more about the future of his business. Dan, welcome to the show. It's great to have you here. Thanks for having me. It's great to be here. Tell us about everything that Every is, because there's a lot going on over there. There is a lot going on. You can think about it in a very simple way. We think about Every as the only subscription you need to stay at the edge of AI. And we have three main pillars of the business. One is ideas. two is apps, and three is training.
15:24On the ideas side, we have a daily newsletter about AI. We do vibe checks. So when a new model comes out, for example, we'll get our hands on that model before it comes out and we'll do a hands-on review of it the day it comes out. We have a lot of stuff like that in our newsletter. We have a podcast. That's the sort of ideas side. Then we have an apps side of the business where we have four AI apps that we build and run internally. Each is run by a single engineer. One's called Quora. It helps you manage your email with AI. One's called Monologue. It's a smart dictation app. One's called Sparkle.
15:55It's an AI-based file manager. And one's called Spiral. It's an agentic ghostwriter. So that's the app side of the business. It's all tools that we build for ourselves to work better on the edge of AI that we also give to our subscribers. And the last part of the business is training. So for people who want to go deeper than just using our tools or reading our writing. We actually do hands-on trainings. We do what we call camps where we, for subscribers, they do, we have live streams where they can see how we use cloud code, for example, or, you know, next week we're having the cursor team on to come talk about how to use cursor really well for AI coding in an enterprise environment, all that kind of stuff.
16:33So we have camps and we have an enterprise offering where big companies, we have an enterprise offering where big companies bring us in to actually train their people. And we bundle this all together in one subscription. And with the apps, I'm curious, is the goal here to compete with, and I'm thinking of email here because email is one where you've got these massive platforms. Is it literally competing with these AI email clients? I'm thinking of the superhuman and stuff like that, or is it a more niche offering? Um, I like eventually, uh, yes, I think it'll, it'll compete with, you know, when I think about the giants, it's like competing with Google or Gmail, like that kind of thing.
17:14Um, for now it works with Gmail, it works with superhuman. Um, and over time we're adding, adding more and more functionality. I think the, the, the market that we're going after is really high taste AI early adopters who want to use features at the edge. And those are people that, um, a company with a much bigger audience can't serve right now. And it's actually quite a small market, but I think it'll be the biggest market in the world in 10 years. And we're really, really focused on those people who want to use an agent like in their email for everything that they do. And that's where we're starting, which I think is very different from a superhuman or a Gmail where they have to sort of split the difference between AI early adopters and everybody else.
17:53Now, agents is kind of an interesting area right now because I look at my own use of AI and I certainly use it, but I don't know that I use as many agents as maybe I could be or should be. And you sit at this interesting junction of trying to convince people to use these agents and embedding that into your apps. I wonder what reflections you've had from building in this space about how you can convince people to use agents because it's a bit of a behavioral leap. And I don't know how you think about incentivizing that? You know, it's ultimately about trust. It's about having an experience where you use an agent for the first time and you're like, oh my God, I cannot believe that actually worked.
18:42And everybody has moments like that. And I think our job as people who make software and also people who write a lot is to help people get to that faster and make sure it's clear what the value is. It's not interesting to use an agent just to say, hey, I'm using an agent. I think in 2025, right towards the end of 2025 is when programmers really began to be like, oh, wow, agents are completely changing my entire workflow. Agents really started there. You can use cloud code for like 20 or it'll go off and code for 20 or 30 minutes or codecs can go off for hours. And that is really changing programming.
19:19And it has not quite gotten to that level for the rest of knowledge work. But I think 2026 is when we're going to see that happen. And the reason for that is all of these coding agents that are built specifically for coding actually translate very well into general purpose agents. And so they're becoming the foundation for general purpose agents that non-technical people are going to be using in 2026 and 2027 and beyond. So if I'm hearing you correctly, you're saying that the key to trust is having a product that works extraordinarily well. And until now, we haven't really seen the models be good enough.
19:54but in 2026 you see them finally crossing that that mark yeah you can think of um models as like having us having a leash and i think you know when ai when gpd3 for example which is the first like real consumer application of lms when chat gpd came out um when we started using gpd3 it was the leash was very short it's like one prompt one response and the response comes really quick and over time that leash has gotten longer and longer and it's the longest right now in coding applications and the leash is only allowed to get longer when the ai is going to reliably do something valuable with that extra time if it's not going to use something valuable it's not worth the time and i think what we're going to find over the next year or so is that leash for non-coding applications is going to get a lot longer because there's going to be a massive amount of value that you see, allowing it to go off and do something.
20:53And a specific example that I can give you that I experience all the time, which maybe people who are watching this are not yet experiencing, is I use an agentic browser. So I use ChatGPT Atlas. It's from OpenAI. And anytime I have to change a setting on a website, for example, I don't have to deal with that. And I get asked that. I get asked for that all the time because I run a company. We have 20 people. I'm always asked, like, can we invite someone to this? Or can you change this security setting on this app. And my browser just now does that for me. So I never have to look at a settings panel ever anymore.
21:25And that's one of those things where it can be a light bulb moment for you to be like, oh my God, this is life-changing. You also are running a media company, which in the era of AI is kind of interesting. And you do some great writing on your website. What have you learned about running a media company in this era that you might not have expected when you started out on this project that's a great question um yeah i i think of everything as being tightly integrated it's ideas apps and training and you know if you want to teach people how to like really live at the edge of ai you need to do three things you need to spread the word and that's the media part of what we do and the stories that we tell you need to um give them tools to use and and we give them tools that we use ourselves and then you have to get hands-on with them to like teach them uh for people who want to go deeper.
22:13And I think obviously media is a critical part of that, but also there's this really interesting thing happening where there's not a clear bifurcation between a media company and a software company anymore. Because you can now program using English, the line between writer and builder is starting to blur. And so everybody internally at Every is both a writer and a builder. So everyone who's writing an article is also contributing to building these apps because you can just vibe code your own product. Exactly, and vice versa. And so that's a big deal. But also another big interesting part of this is that because software is so cheap to make now, it actually has a lot of the same properties, like building a new app has a lot of the same properties as writing an essay or making a video.
23:02You can think of software as a form of content now. And so that's another reason why the software part of things is not separate from the media part of things, because for us, if a new model comes out, we can go Vibecode a new app to display its capabilities and then launch the app. And that's the equivalent of writing a really cool article about it because we're showing people, hey, we built this thing. And it's not an app that we necessarily are going to support. It's just like a demonstration of what's possible now. And I think that's really interesting. Great. Well, Dan, I want to thank you for coming on.
23:34That is Dan Shipper, co-founder and CEO of Every here on TI TV. Okay. If you live in New York, you might have seen the subway ads of Serena Williams injecting herself with GLP-1s. The company behind that ad is health tech company Rho. And this week it announced it is now offering the new Wigovi pill from Novo Nordisk. I want to bring on Zach Raytano, the co-founder and CEO of Rho to talk about his business. Zach, welcome to the show. It's great to have you here. Thanks for having me. So this is the pill that you can take. We're done with injectables. Are those going away? I don't know if we're done.
24:11I think this is a yes and. This is really exciting. That's right. But I mean, long term, I mean, the injectables, they'll probably go away, right? I think it'll depend on the individual. And the main reason is, so the amazing thing first to talk about the pill is I do think that it is going to usher in a new era of digital health, direct-to-consumer health. It's the first time a drug of this size and scale launches nationwide on-road. So someone can see an ad and go from diagnosis to delivery in 48 hours or less. And the cool part about this pill in particular right now is, one, it's more affordable.
24:46So it's $149 to start. But two, to your point, patients don't have to trade off between efficacy and the preferred form factor for many. So patients on treatment saw about 16 % to 17 % weight loss on the pill. That's going to be transformative. So it's a better form factor for many. It's more affordable and it's available today on Rho. The thing that you mentioned about injectables is you do see both current injectables. There are some where patients lose 20, 22 percent and there are TLP ones in the pipeline. Maybe people have heard of in Silicon Valley, maybe they've heard of Triple G or Reditrutad or Cagrosemma.
25:22There are others that are coming out in 26, 27, 28 and beyond where patients are losing 25, 30 % of their weight. And so you will usually see the pills be slightly less effective over in the fullness of time. So it really depends. What about side effects? Is there any difference in terms of side effects? They're quite comparable. They're quite comparable, the pill and the injectable. Yeah. And generally speaking, I mean, side effects are, I mean, where are we in that story of people seeing any kind of adverse effects here? Yeah, the typical ones that people see are, nausea or gastro challenges and issues.
25:59And in terms of the frequency, over in the clinical trials, it might be 30, 40 % of people. But the side effects, and it depends how wonky you want to get, they usually subside over time. They're usually what are referred to as peak to trough side effects. So it's when people start or they escalate in dose. And there are ways to mitigate those things and we educate patients and care for them along the way to help mitigate those, but they usually people can get comfortable and subside over time. I want to ask you a question about the broader healthcare landscape right now. It's been kind of a newsy week for the space because OpenAI has made this new deeper push into health tech with its new platform.
26:46And one of the interesting things that we've talked about on this show is OpenAI integrating with all these different platforms, not just in healthcare, but other apps and tools as well. But the broader question I have for you is, so OpenAI is going to make sense of all this data with ChatGPT, and maybe you can link up your MyFitnessPal or maybe your Apple Health at some point. And the business question that I have in my mind is, isn't there a risk that these companies integrating with ChatGPT could just end up cannibalizing their own business and the value proposition that they had in the first place?
27:23How do you think about that issue? Well, from our perspective, I think one of the... So first, I think it's a great launch. It's exciting. I think that healthcare, the established healthcare system, I think over the last 20, 25 years has had its chance to use technology and clearly has come up short for a lot of people. And I think this is just a preview of things to come. So it is really exciting. I think for us, the thing that we really see about AI, not only using it internally a bunch, but when you see right now in ChatGPT, oftentimes it'll caveat or other AI LLMs, you'll see it'll caveat and say, this is not meant to replace your provider.
28:00And so what we really think about is, okay, all of that data, how do we make it actionable? And at some point in time, right, we want to make that data actionable. I mean, that might be a prescription, that might be provider guidance, whatever it may be. So for us, we actually just think that the more patients are engaged with their health, the more that they can turn that unstructured into structured data and get feedback in real time, the better off they'll be. I think an interesting analogy here for Silicon Valley that's obsessed with how does AI really spread throughout healthcare, I think driverless cars are actually a really good analogy here, right?
28:35And the reason I say that is you have some pockets where you'll see these very controlled experiments where they'll be fully autonomous, right? So that's like a Waymo driving around Palo Alto or SF. you'll see similar things in healthcare, right? So an insulin pump is sort of the V0. It's deterministic, but it's making automated decisions, right, in real time. You saw in Utah this week, Utah is rolling out a pilot where refill prescriptions can actually be done entirely by AI. So these very controlled experiments and they'll roll them out over time. And then you do have the equivalent of what we've seen more in like Tesla, FSD or lane assist or parking or things like that, where it complements the human driver.
Read the full transcript
29:15And you're going to see a lot of that as well, probably spread far faster. The interesting thing to me is the society's perspective is we have this massive supply chain shortage in healthcare, right? Too many people need it, too few to provide it. That's hopefully what AI does. The societal question, I think we're at, we're facing it with driverless cars is basically like how much, it's an odd way to say it, but how much debt are we willing to tolerate in the interim? because driverless cars, in many ways, we don't hold the bar that they need to be better than the average driver or even the best driver.
29:46We hold the bar that they need to be 10x better. And I think we're probably going to do the same with healthcare, so it'll be interesting to see how it rolls out. But I think that's a good analogy for people. So let me ask you another question there on that societal sort of piece of all this, which is that we had a doctor on this show earlier this week talking about the question, Who is accountable in the scenario where somebody goes to an AI platform for health advice and unfortunately something goes wrong? You know, there is a question about is it the platform? You know, was it was there a doctor at all in the loop?
30:25Yeah. How do you think about that question at Ro? So for us, the way that we think about it is for things like that, the doctor will be in the loop. And I think there's very, very clear regulatory guidelines in the practice of medicine. And I'll give an example of where we use AI to give our providers leverage while dramatically improving the patient experience. So right now, patients can report a side effect. And they could do that historically in a structured way. So what side effect they're experiencing, the severity, the duration, any other associated side effects, whether they can still move throughout their day or take the medication.
31:01That would create a task for a provider to review. And 24-7, our side effect response time was under an hour. Then with the launch of these LLMs, every single, we could take tremendously unstructured data and make it structured. So if you're talking to Ro and you send a message, every message is routed to an LLM. We can actually flag whether a side effect is reported in that unstructured message, create a task routed to a provider. And we've published this data. We've been able to reduce the speed with which a provider can respond to a side effect by 70%. So 24-7, the median response time to a side effect on row is 15 minutes.
31:37That was impossible to do before LLMs. So I think it's going, and that's where I think, again, the driverless cars are a good analogy because I think it's more familiar to people, but there's an entire spectrum of autonomous. There's multiple levels, how involved the human driver is, whether there's a test-controlled pilot or highways or all of these different smaller pockets and use cases. So I think that's a good analogy, but that's how we think about it. The last thing I want to ask you about before you go is this conversation around peptides is like everywhere now. You know, everyone is talking about— Peptides and microdosing, right?
32:15Peptides, microdosing. Look, the idea of getting drugs or medications directly from a manufacturer, I don't know. I would never do it, and I'm surprised that people do. But we are in this Silicon Valley era of people trying new things. how do you think about moonshot bets at Rho and what do you have your eye on in terms of innovations that are coming down the line? Yeah, so there is this large, as you said, there's this large peptide craze. I think it's a very hot, like generic term because I think the most popular peptide will be GLP-1. Right, I was just going to say, I mean, that is literally a peptide.
32:49It's literally a peptide. You know, insulin's a peptide. We've been treating, you know, hundreds of millions of people have been taking peptides for the last basically century since insulin was invented about 100 years ago. So it's not a new concept. I think the same just needs to be applied. The same logic that we would apply to this. I think what you're seeing with people taking more action and how I take this peptide craze or this microdosing craze. And by the way, I think microdosing, I have an issue with the term, which I'm happy to talk about it, which I think it's like next time we can do it.
33:21But I think that you're just, what you are seeing, it's a signal of how fed up people are with the traditional system, right? They're taking more into their hands. COVID, I think we lost a lot of trust in institutions and you're seeing that. I think this is just one other example of that. And, but I do think that the traditional system, to your point with manufacturers, they are investing more in direct to consumer and empowering patients. And I think the companies that win in the future are the ones that lean into that and lean into empowering the patient and the provider to collaborate, to achieve their goals.
33:52Great. Well, Zach, I want to thank you for coming on. We appreciate it. And next time you come on, we will have you give us your hot takes on micro-casting. I'm sure that'll be a fun conversation. I appreciate that. That is Zach Ray Tomlin, the co-founder and CEO of ROW here on TITV. Okay, for this week's Editor's Cut, we want to take a look at the AI and the shopping story. E-commerce has become one of the biggest applications for AI that many companies are trying to expand into. I want to bring on our editors Martin Peers and Meredith Mazzilli to talk about some of the dynamics at play right now.
34:25Welcome to you both. It's great to have you here. How are you? Hey, Kyle. I'm doing well. And just to set the scene here for people, Meredith and Martin sit next to each other. Okay, so I'm expecting a dynamic, lively conversation. Go right now. Meredith, there's a phone. I'm in the office. In the office, right. Got it. Not collaborating, yeah. Yeah. There's no collaboration whatsoever. Barrett has just gotten out of her pajamas and she, whereas I'm here in the office. All right. Well, let's just talk about e-commerce. How about that? So I'm going to put a prediction ahead and I want your thoughts on this, which is that I actually think that Amazon is going to make a lot of noise this year in the AI e-commerce story.
35:12I think they're going to push ahead in some cases. And I think this is going to be the year that Amazon finally breaks out. I think shopping is going to be at the center of that. Meredith, what do you think of that prediction? Hey, thanks, Akash. So I largely agree with your position there. I have a couple asterisks, but I will get into that. So first of all, off the bat, agree. Amazon is already obviously a massive destination for online shoppers. It's a place where people go where they expect to shop. I don't know that that's the same of ChatGPT, Copilot, everybody else that's trying to roll out these shopping tools.
35:47And user habituation right now is a big question. Will people actually use AI to shop? And I think Amazon has a big leg up there. And more importantly, we're seeing this week especially evidence that Amazon is getting its AI agents or what they call agents to actually shop online, which I can get into that later, but it's a lot harder than it might sound. And the reason we know that they're doing this is that small retailers started to get pissed off about it. Am I allowed to say that on this show? You are very much allowed to say it. Because we saw a bunch of little retailers that don't sell on Amazon.
36:24They don't like slash probably hate Amazon saying, hey, like we're seeing our stuff show up through this agentic tool and we're getting sales via Amazon and we don't like that. So in a weird way, the fact that other retailers are starting to notice and they're getting ticked off, that is showing that Amazon's AI tools are actually working, which at this stage of the game, just having something work, even if it's not perfect, is being ahead. Okay, so Martin, Meredith thinks, she agrees with me actually, this is going to be the year. What do you think? Well, I mean, I think that's like saying that, I don't know.
37:02I mean, that doesn't mean very much to me. Amazon has been very quiet on the AI front, so it wouldn't be hard for them to make more noise this year. And I agree that they will, but I just don't think that that means much. Look, I'm very confident that Amazon will, in the end, do very well in AI as far as it needs to. It doesn't need to spend the money that some of the other companies are spending. You know, they just need to spend the money to ensure that their cloud service has the capacity to meet demand and to ensure that the AI products for Amazon.com work. And I'm sure that they will actually do that.
37:45But, you know, I don't think that they're going to make a whole lot of noise, anything like what Google has done or OpenAI. Yeah, sure. But I mean, I think the AI component of AI shopping, as we're thinking of it now, is very small compared to the retail component. And that's where Amazon's really good. And, you know, we covered this with OpenAI this week where there's this recurring problem with AI shopping agents where they just get tripped up by product data, by little details that you might not think about, like sales tax in different states, stuff like that. And then they just don't work.
38:24So like what OpenAI is trying to do is team up directly, which has very little to do with AI, just kind of plug in directly with retailers, with payments firms, with this AI layer over it. Like, yes, Amazon's AI is probably like less good in that sense, but the underlying commerce part, I think they still have an advantage there. Cash, you didn't tell me that we're having an Amazon spokesperson come to market. Oh, wow. This is my caveat, though. And I'm circling back to this from the beginning. And all the hype around AI agents is this idea that, okay, we're going to have this personal shopper-like tool that goes out there, it buys your stuff, it makes an outfit for you, it picks something out for your dad that's impossible to shop for and never likes what you get him.
39:11This is like a personal issue for you? No, no, no. So we are so far from that. We are not even close. the way that AI agents are working now is within very set boundaries and in very specific situations. And that, that is why Amazon is doing okay. And like, I think if somebody can figure out how to make that bigger picture thing, this like ideal a reality, there's like that, that is a huge blank open space for sure that, you know, like I, to agree with Martin, I hate to say, or least like somewhat go on his side, like that is not something that Amazon's doing yet. Martin, we had Catherine Perloff on the show earlier this week talking about her reporting.
39:56And I was talking to her about some of the core reasons that Amazon may have fallen behind in the AI conversation, at least from a narrative point of view. And look, she mentioned that Google had some very early efforts in AI and Microsoft obviously had its open AI investment. Amazon, you know, there was no sort of clear early project that really may have given it a head start. Do you agree with that being a core reason? Are there other reasons you think are at play? No, I think that that is the main reason. Google, Meta, Microsoft, all of them had been in AI for years. Amazon wasn't. I'm not sure, as I said, that Amazon needs to compete with those other companies in that same way.
40:43that they need to do AI as it serves their needs. And I think that they've taken a very smart approach to not try to compete with the others. Meredith, you pointed this out this morning that this week, Microsoft also said that it was going deeper into e-commerce and shopping. They did. And they announced something that is quite similar to the open AI checkout. So just to zoom out a little bit, what that means is inside Copilot, inside ChatGPT, these companies say you will soon be able to buy a lot of different stuff without leaving the window. And they say that's a really big deal because every time a shopper leaves the window, has to go to another website, you lose a few shoppers along the way.
41:28So I'm going to use some jargon that Martin will hate, but the shopper conversion within the... They convert to what? How do they convert? What's the conversion? Yeah, it's better is what they say. But again, like this, that approach is just not really working yet. It's working on a very limited basis. And then what Amazon is trying to do is much more like go out to the web. Again, not really AI, like scraping stuff basically sounds like a bot, right? And then finding stuff and bringing it back. I mean, Akash, you have to remember we're in the period right now where companies are announcing things constantly.
42:07Many of these announcements, you know, will never work and we'll never hear anything of them. But the media being what it is, they write them up as though they're really important. So we have to treat everything, you know, skeptically. Yeah. And just like agreeing with Martin again, I don't know how this keeps happening, but I will point out that the initial OpenAI announcement, around these checkouts came, I believe, in September. So before Black Friday, Cyber Monday, like the Super Bowl of retailers each year, that came and went and these checkouts weren't really scaled up. So it's not gonna be until the next key shopping period at the earliest that we're really gonna see this potentially be positioned to take off.
42:53And I think we were hearing in the reporting that a lot of retailers anyway, don't like making big changes before the holiday season. So the timing of that was interesting that it came out. And look, the other thing is that people liked to buy things. So I'm not sure that they really want to turn over that behavior to some agent they liked. Well, that's actually a good point. Yeah, I mean, I hadn't thought about that. I mean, having agency over the thing that you buy is in and of itself a very satisfying... People enjoy the experience mostly. Not everybody. Right. All right. Okay. Well, I'll tell you what, that's a good place to end it.
43:31I want to thank you both for coming on. That is Martin and Meredith, two of our most fun editors here at The Information for this week's editor's cut. Okay. You know what? Get out of here. I'll talk to you guys very soon. All right. Where are we in the show here? Okay. Many health tech companies now are starting to offer products and services now that will tell you your biological age. My colleague Jemima McEvoy wrote a deep dive in our Weekend Magazine about that trend and about some of the complexities that come up with companies offering these new features. I want to bring her on to talk all about it.
44:09Jemima, welcome back to the show. It's great to have you here. Hi, Akash. It's great to be here. I should preface this by saying, look, we've talked a lot about health tech on the show so are today. We've talked about GLP-1s. We've talked about peptides. We almost talked about microdosing. We didn't quite get there. And so biological age is right on the money for the realm of things that I want to get to. Did you track your biological age as part of this story that you wrote? I really wanted to, but because of the timeline with the story, we were worried that the results wouldn't come back in time.
44:45So yeah, because this is different than looking at your watch. This is not like telling me, like, oh, my whoop tells me I'm younger. No, no, no. So that's different. There's lots of different types of biological age tests, and those are more just measures. They're a little more casual. The ones that I'm talking about in these stories are the kits that you order to your house. You take a cheek swab or a blood sample, send it off to a lab, and then a few weeks later, they'll send you back your score based on a variety of different measurements. Interestingly, though, one founder that I spoke to who runs one of the companies that sells biological age tests, he told me that he thinks that the best way to measure biological age might be by just looking at your face and guessing your age based on...
45:36Shocker. You look. Waking up in the morning, looking in the mirror. Yes. And he said that my age was what it actually was. He just guessed it. So anyway, I don't know what that says about my... Do we do that? We just look people and guess their aim? Is that something we do? In this world, yes. I guess so. Okay. Well, look, I liked your story a lot because it dived into the way that Silicon Valley has embraced it, not just from an adoption perspective, but also from a business perspective. Talk a little bit about who the big companies are, how much money is going into this space, and then really what some of the complexities are around being able to say that you are 30 years old, but you're actually 25 or you're actually 35.
46:19Yeah. So there's, by my count, there's 15 different companies that are selling biological age tests. I mean, a lot of them are different versions, which I'll get into in a second. But also by my count, these companies have raised around$800 million. It's worth noting, though, that a lot of these companies do sell other stuff like supplements, longevity-related things, like other health testing kits that aren't focused on biological age, but they offer these tests too. And so the complexities is that, well, there's one big one, which is that I spoke to a bunch of scientists in the space, and they all agree, including some of the scientists who develop the technology that are used in some of these commercially available clocks, and they all agree that you can't definitively say that we can measure biological age because there's no definition.
47:08It's not like height or weight where we all agree like you measure height and weight in a specific way. Biological age, there's no consensus. So it's confusing to consumers. You're going to get different scores depending on the test that you choose to do because a lot of them are measuring different things. Right. Now, what do the companies say about this? What's their rebuttal? Yeah, a lot of them argue that it's useful to track over the long term, so tracking trends. Relatively speaking, I mean, even if you're not the same as what the other company says, if you're getting younger, it's better.
47:48Exactly. So test yourself every six months, watch how that changes. The problem is in a lot of these companies' marketing, it's a lot more definitive. Like, we're going to tell you your biological age. This is how healthy you are. In some cases, arguing this is like the best way to look at how your body is doing internally. So there's kind of this difference between how these companies are marketing, what they can do versus what they can actually do. Also, the experts I spoke with were divided on whether there's actually any value on tracking over time either. You know, if the tests aren't particularly accurate in the first place, why would it be valuable to check over time also?
48:28And then just one more point I want to mention is that I'm not trying to say that biological clocks are completely useless. They've been used in aging studies and continue to be used in research a lot. The problem is that they have been started to be sold commercially without really checking how useful they are on an individual level and how accurate they are on an individual level. So there's kind of this difference between being able to measure like changes in populations versus testing how effective they are for individuals. Was there a particular story that you heard over the course of your reporting that really just shocked you about the lengths that people will go to?
49:07Maybe not just to measure their biological age, but look, we've been talking all day today about the crazy things people are trying to get information about their bodies and about how they can improve. I mean, is there a story that stands out to you that you were just flabbergasted about? Yeah, I mean, I do think that this is a small subset of people that are really on the extreme end of this. But among those people, there are a lot of great stories. I mean, one founder I was speaking with, he told me, and this is in my story, but one of his friends texted him after getting her results back from a biological age test she did, and she showed up as being 10 years older than she is in reality.
49:49And she was just begging him over text, like, what can I do to change this? I'll pay you$10 ,000. You know, that may have been an exaggeration and perhaps - $1 ,000 for every year. I mean, that's the going rate, I guess. Seems reasonable. But I mean, there are a lot of people in Silicon Valley who really care and are hoping that we can reverse aging and think it's on the horizon. So yeah, I don't think this is going to go away. And last question for you, do you think, well, actually, you just answered, I was going to say, is this a fad? Is it going to go away? So you think this is here to stay?
50:22Yeah, this is definitely here to stay. And, you know, the scientists in the space keep saying that there are, you know, big breakthroughs coming and there's a lot of hope that there's going to be breakthroughs in the industry and investors just seem to be willing to throw a lot of money at it, even though, you know, we haven't seen any massive, massive breakthroughs yet. So yeah, I don't think it's going to go away. Interest is going to stay. Great. Well, Jemima, I want to thank you for coming on. That is Jemima McAvoy, our weekend reporter here at The Information. Okay, that does it for today's show.
50:56A reminder, we are on this stream Monday through Friday at 10 a.m. Pacific, 1 p.m. Eastern. I want to thank you all for tuning in. We really do appreciate your viewership. I'm already excited for our next show tomorrow. Ah, not tomorrow. Today's Friday. I'll see you on Monday. Have a great weekend. Talk to you soon. Bye-bye for now.
From the publisher
Asia Bureau Chief Jing Yang joins TITV Host Akash Pasricha to discuss exclusive reporting on DeepSeek's new V4 flagship model and its superior coding capabilities. We also talk with Cory Weinberg about Strava's confidential IPO and Lambda's $350M raise, and Every CEO Dan Shipper about how AI is blurring the lines between media and software. Then, Ro CEO Zach Reitano breaks down the launch of a new GLP-1 pill with Novo Nordisk and AI's role in modern healthcare. Lastly, we dive into the Silicon Valley obsession with biological age with Jemima McEvoy and the AI shopping race with Editors Martin Peers and Meredith Mazzilli.
Articles discussed on this episode:
https://www.theinformation.com/articles/strava-filed-confidentially-ipo-hired-goldman-sachs
TITV airs on YouTube, X and LinkedIn at 10AM PT / 1PM ET. Or check us out wherever you get your podcasts.
Subscribe to:
- The Information on YouTube: https://www.youtube.com/@theinformation
- The Information: https://www.theinformation.com/subscribe_h
Sign up for the AI Agenda newsletter: https://www.theinformation.com/features/ai-agenda
