In short
James Altucher interviews Charles Duhigg about how GLP-1 drugs (especially tirzepatide/Zepbound) reduce “food noise,” shrink appetite, and create a “habit window” that can make eating changes persist after stopping the medication. They discuss habit loops (cue-routine-reward), keystone habits, identity alignment (stated vs revealed preferences), and long-term outcomes/weight regain.
Guest backgrounds
Charles Duhigg is the author of The Power of Habit and Super Communicators. Altucher says he has personal experience taking GLP-1s and has lost about 45 pounds.
Key claims
Food noise quiets, cues fail to trigger cravings, and stomach emptying slows; real life change often appears around 4–6 months. If habits aren’t changed during the window, weight often returns quickly after discontinuation. Structured habit systems (e.g., Noom) help.
Notable examples
French fries cueing automatic eating; switching to stopping mid-meal; drinking less; improved sleep and exercise; Altucher’s COVID-related GI confusion; keystone habit chain reactions (exercise, alcohol, sleep).
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VOPersonal Experiences with GLP-1
0:00 to 0:10
James shares his motivation for starting GLP-1 and the impact it's had.
“From Taco Night in Tulum to Sushi in Tokyo, make every bite rewarding with gold from Amex.”
Personal Experiences with GLP-1
2:13 to 3:56
James shares his motivation for starting GLP-1 and the impact it's had.
“I started taking GLP-1s, the so-called weight loss drugs.”
Understanding the Impact of GLP-1
3:56 to 6:28
Charles discusses how GLP-1s change food cravings and eating habits.
“That six or seven months, that's how long it takes?”
The Science Behind Habit Change
6:28 to 12:13
Exploring how GLP-1 quiets food noise and opens opportunities for habit formation.
“your basic habits around eating and other behaviors.”
Effects of GLP-1 on Enjoyment and Cravings
12:13 to 14:01
The conversation delves into how GLP-1 affects food enjoyment and cravings.
“even when you discontinue the medication, the habit remains and the weight loss is persistent.”
Impact of GLP-1 on Pleasure and Cravings
14:01 to 15:24
Learn how GLP-1 affects cravings and pleasure from food and substances.
“Like I find that, for instance, I eat more sweets on this GLP-1 because I think I'm seeking out stronger flavors.”
Keystone Habits and GLP-1
19:35 to 23:04
Understand the concept of keystone habits and their connection to GLP-1.
“Okay, so two, three weeks in, what did you notice?”
Identity and Behavioral Change
23:04 to 27:47
Explore how changes in identity influence behavior and choices.
“influence your life if you are using them the right way.”
Placebo Effect and Health Identity
27:47 to 28:00
Learn about the relationship between placebo effects and perceived health identity.
“my sense of identity has started to change.”
The Placebo Effect and Identity
28:00 to 29:05
Learn how the placebo effect influences identity and behavior change.
“like human growth hormone, I'm going to grow muscles.”
Show all 21 chapters
The Power of Alter Egos in Performance
29:05 to 30:23
Discover how athletes use alter egos to enhance their performance.
“I'll say there's a lot that we don't know about the placebo effect, sort of mysterious.”
Micro Habits for Effective Change
30:23 to 31:49
Understand the importance of starting small when changing habits.
“before every single practice and every single race.”
Behavior Changes with GLP-1
31:49 to 33:42
Explore how GLP-1 influences eating behavior and reduces cravings.
“How do I build them and track them in a way that I feel like I can see this echo in my life?”
The Mechanism of Weight Loss Drugs
33:42 to 35:07
Learn how GLP-1 affects metabolism and appetite regulation.
“noticed in the first three or four months is that my behavior changed almost in ways that I wasn't I wasn't even having to choose.”
Long-Term Effects of GLP-1 and Habit Formation
35:07 to 36:30
Understand the importance of habit structures for maintaining weight loss.
“are getting consumed into energy, right?”
The Relationship Between Weight Loss and Lifestyle
36:30 to 37:58
Explore how weight loss impacts lifestyle and reinforces positive behaviors.
“like a healthy amount of food a healthy a healthy diet in addition i think oftentimes your your blood sugar has stabilized at that point.”
Challenges of Discontinuing GLP-1
37:58 to 40:16
Learn about the challenges faced when discontinuing GLP-1 use without new habits.
“I find that it's easier to go running in the morning.”
Personal Insights on GLP-1 Use
40:16 to 42:01
Hear personal experiences regarding GLP-1 and its impact on health.
“And so I'm telling myself I'm doing this for my health.”
Understanding Weight Loss and Health Goals
42:01 to 45:50
Discover how weight loss is tied to body composition and health markers.
“Like, it's not like they're still having granola.”
The Role of GLP-1 Medications
45:51 to 49:59
Learn about GLP-1 medications and their effects on weight and health.
“I mean, I find it very easy to maintain right now, and I take a relatively low dose, and I enjoy not having that food noise in my head.”
Behavior Change and Tracking Progress
50:00 to 52:16
Understand the importance of tracking behavior changes in health journeys.
“We can choose to be the person we want to be rather than relying on the influence of outside substances.”
Transcript
Automatic transcript. May contain errors.0:00James Altucher:From Taco Night in Tulum to Sushi in Tokyo, make every bite rewarding with gold from Amex. Wherever you dine, four times the membership rewards points at restaurants worldwide are piling up. Learn more at AmericanExpress.com slash Explore-Gold. Terms and points cap apply. This message is brought to you by the Capital One Venture X card. Venture X offers the premium benefits you expect, like a$300 annual Capital One travel credit for less than you expect. Elevate your earn with unlimited double miles on every purchase, bringing you one step closer to your next dream destination. Plus, enjoy access to over 1 ,000 airport lounges worldwide.
0:37James Altucher:The Capital One Venture X Card. What's in your wallet? Terms apply. Lounge access is subject to change. See CapitalOne.com for details. This episode is brought to you by Progressive Insurance. Do you ever think about switching insurance companies to see if you could save some cash? Progressive makes it easy. Just drop in some details about yourself and see if you're eligible to save money when you bundle your home and auto policies. The process only takes minutes, and it could mean hundreds more in your pocket. Visit Progressive.com after this episode to see if you could save. Progressive Casualty Insurance Company and Affiliates.
1:12James Altucher:Potential savings will vary. Not available in all states. Today on the James Altucher Show. Not only do your eating patterns start to change, we could talk about why exactly that is, but also your stomach shricks. And so as a result, your body has adjusted to having less food and needing less food. So I found that I've lost like 45 pounds on a GLP-1. Something happens, the food noise in your head quiets, and that opens this habit window where you have a period when you can change your basic habits around eating and other behaviors. People don't notice the food noise inside their head until it's gone.
1:55James Altucher:This isn't your average business podcast, and he's not your average host. This is the James Altucher Show.
2:12James Altucher:I'm doing a big experiment in my life, a big life change. I started taking GLP-1s, the so-called weight loss drugs. It's not actually, I'll explain why I'm taking them. It's not necessarily because of weight loss, but I wanted to talk to someone who's had some experience taking this and it just turns out Charles Stuhig, the author of The Power of Habit, he told me he was taking GLP-1s and it's incredibly changed his life. But the key is, does it also change your habits? So even when you're off the GLP-1s, the good habits you develop while taking GLP-1s continues. and what else happens on GLP-1s?
2:53James Altucher:Are they good for you? Are they bad for you? What's the long-term results? Talking with Charles Duhigg, author of The Power of Habit and Super Communicators.
3:08James Altucher:I'm so glad you wrote to me about, you know, I just started taking this Terzapetide. Oh yeah. Yeah. And I didn't really know what to expect one way or the other. The doctor said, oh, there's going to be some side effects. and we'll just see. I just started taking it because he wants to get me to the retro, whatever. Right. But I haven't graduated to that yet. And then I thought I was having a massive effect from it, but it turns out to be this COVID effect. So it was apparently diarrhea was a big part of his latest bout of COVID. So I thought like, oh, finally the peptides are kicking in. This is pretty vile.
3:45James Altucher:How long have you been on the GLP-1? Just about three weeks. Oh, okay. Okay. So you're really at the beginning of it. So I've been on one for two years now. You really start to see the effects like six or seven months in. That six or seven months, that's how long it takes? I mean, no, you start seeing effects before then, but like the real like life change comes after a couple of months, right? Like four or five or six months. And the reason why is because not only do your eating patterns start to change, and we could talk about why exactly that is, but also your stomach shrinks. And so as a result, your body has adjusted to having less food and needing less food.
4:24So I found that I've lost like 45 pounds on a GLP-1. What GLP-1 are you taking? I take Zep-out, the equivalent of Zep-out. I think that is trizepatide. I think you're right. I think that's trizepatide and the other one is semiglutide. Yeah. So I'm on the same one that you were on. And I found that, you know, I saw like a little bit of weight loss and like change in my hunger profile. Well, it definitely I saw a change in my hunger profile and particularly change in my eating habits in the first six months. But the point at which I started losing a lot of weight was really like six to eight months in.
4:57Then it becomes like flipping a switch. You can kind of just decide how much you want to weigh and do that.
5:03James Altucher:And so what happened at first? First off, why did you start taking it? Did you start taking it for weight loss? So the reason I started using a GLP-1, and I really think it's a great medication. and it's had a huge impact on my life, is that there's kind of these two phases of GLP-1s, right? Phase one is the phase we just lived through where everyone recognizes this is something that can change your food cravings. It can change your weight. It can help you lose weight. It can help you eat more healthily. And that's kind of the phase one. And what we're learning right now, and that's when I started using a GLP-1.
5:38But now we're actually in phase two of understanding how GLP-1s impact our life. And the thing about this phase too is what we're realizing is that one of the big reasons why GLP-1s are so powerful is not just because they change your biology, it's because they allow you to change your habits, right? And I've actually been working with this company, Noom, that's like an app that people might be familiar with. It used to be for weight loss. Now you can actually order GLP-1s through it. But the reason it's important is because the app helps you change your food habits when you're on the GLP-1. And what we found is that when you start taking a GLP-1, and you're probably at the beginning of this, something happens.
6:19The food noise in your head quiets, and that opens this habit window where you have a period when you can change your basic habits around eating and other behaviors. And if you do so, then even once you discontinue the medication, the behavior change remains. So I don't know. I mean, again, you just had COVID, so you might not be able to tease out the GLP-1 versus the disease. But do you find that the food noise in your head has quieted since you started taking the trisepatide?
6:51James Altucher:It is hard to tell because the first two weeks, I was feeling super bloated. And I don't know if that was related to the peptide or not. And then one day, I decided I'm going to take a little more, almost like a double dose. and I'll just be graphic. My stomach completely exploded. I was going to a business meeting and I was just stuck in the bathroom all night in this hotel. And I thought, oh, this must be the peptides kicking in. I felt like I lost 20 pounds right there. But then later that day, I had COVID. Yeah, I think that was the COVID. That's not a much reported side effect of the GLP-1 use.
7:40If anything, it actually does the opposite because it slows down how quickly your stomach releases food.
7:45James Altucher:That's what I thought. So I guess I don't really know how it all works. The reason I started taking this is that I haven't really been to a doctor since I was 18. I'm 58 years old. And so recently I hired a concierge doctor just because I figured I got to have somebody I need to call just in case something happens. and he said, well, you need to get some blood work. We just got to at least have your blood work. And on my blood work, everything was fine, but there was a small indication that maybe I have prediabetes, but I also had a tooth infection. He said, it's probably just related to that tooth infection, but just in case, let's try this trisopetide that people are on.
8:23James Altucher:And that's an anti-diabetic thing. And so I said, okay. And so that's really where I'm at with it right now. So, okay. So, so let me talk about what this food noise. So, and you might be finding this now that you're over COVID, you might start to notice this. So, so oftentimes what happened, and this is exactly what happened to me, is that people don't notice the food noise inside their head until it's gone. But the way that it would manifest for me is like, if I sat down at a table and there was a basket of fries, even if I was not hungry, even if I was totally full, even if I said to myself, like, you shouldn't eat any of those fries.
8:58At some point, I would reach over and I would grab some French fries and I would eat them, right? And it almost happened unthinkingly. And the reason why is because when you see the fries, it triggers a set of habits that you've built up around French fries. And we can talk about what those habits are, but it triggers those habits. And as a result, there's a pull, a kind of a low-grade craving that you have for the salt and the oil and the crunch of putting the fry in your mouth. And so what's happening there is that the habit's getting activated because every habit has these three components, right?
9:30And we've talked about this before, that a habit has a cue, which is like a trigger for an automatic behavior to start, and then a routine, which is the behavior itself, and then finally a reward. Every habit in your life, which is about half of what you do every day, delivers a reward to you whether you're aware of it or not. And this is known as the habit loop, the cue, routine, and the reward. This is how a habit exists inside your brain. And so when I sit down at a table and I see a basket of French fries, that's the cue, right? And what the cue does is it triggers that craving for that reward.
10:00I know that if I put the fries in my mouth, it's going to taste good and give me like a little burst of flavor reward. And that becomes this craving that causes me to reach over almost unthinkingly and put the fries in my mouth. So what does the GLP-1 do? Well, what the GLB-1 does is, again, it creates this window where habits can change. And the window isn't open forever, but it can be open for a good long time. And in that window, when I sit down at the table, I see the French fries and the cue fails to get activated. I see the French fries and I just think, I don't start envisioning the reward of eating them.
10:37Instead, I just see fries. But the the noise inside my head, the cue that would normally be there, it has been quieted by the GLP-1. And into that moment, I can start to build a new habit, right? I can start to say like, oh, actually, like when I sit down at the table, like, it's not that I want French fries, it's that I want something crunchy. So I'm going to eat some of these carrots instead. Or it's not that I'm hungry, it's that I'm bored. And so like, I can just ignore the fries and pay attention to this conversation that's happening. What's going on in the brain when the GLP-1s kick in? So we're not entirely certain.
11:12We know what GLP-1s do to your stomach, for instance. As I mentioned, it slows down the release of food. We know that a GLP-1 is a glucagen-like peptide, right? And we know that glucagen plays a significant role in why our brain craves certain things. we don't know why that food noise quiets when we're taking a GLP-1. Because there's just a lot that we don't know about our brain and about desire and about GLPs. In particular, we're learning that glucogen is a much more interesting and complicated and sophisticated substance than we previously understood. And so we don't know exactly why that's happening, but we do know the effect, right?
11:48We know the effect is that people, when they start on a GLP-1, not right away, but at some point, if they have a system for doing so, their food habits actually change. And if those food habits change, if new habits take hold, new cues, routines, and rewards, then even when you discontinue the medication, which for many people, they want to eventually discontinue the medication, even when you discontinue the medication, the habit remains and the weight loss is persistent.
12:19James Altucher:And what if you don't change the habit while you're on the GLP-1s? What if you keep grabbing for the fries? On the GLP-1s? Yeah. I mean, you probably won't, to be honest. Like, you'll just find that, like, your interest in the fries is much less. Because that food noise has been quieted, the queue is no longer there. On the GLP-1, you're probably not going to grab for the fries. You're just going to, like... I mean, you'll have one or two, and then you'll be like, I'm kind of full. But what happens if you don't change your habits is that when you stop taking the GLP-1, when you discontinue the medication, you'll go right back to those old behaviors, and you'll gain the weight back almost immediately.
12:54People start regaining weight after discontinuing a GLP-1 almost immediately unless they have some kind of structured habit intervention while they're using the drug to build new habits.
13:05James Altucher:And if it quiets the food noise, I was reading how Sam Altman, who was taking the same, Sam Altman's the head of OpenAI, and he was apparently taking the same GLP-1 that you and I both are taking. and he ended up in the hospital. And I forgot the reasons why he ended up in the hospital, but one thing he spoke about was what he calls, I think I'm pronouncing it right, anhedonia, which is he lost his desire for everything. Yeah, so anhedonia, I didn't see that. I won't talk about Sam Altman, but I'll talk about what the clinical studies say. So oftentimes people on a GLP-1, they do find that they enjoy food less.
13:43It's not that they don't enjoy food, But, you know, take someone like me who like loved to eat and as a result ate too much, ate too excess. You know, I really looked forward to eating. And like afterwards, I would feel so satisfied. Even if I was feeling guilty for eating too much, it gave me a real sense of satiation. And that does diminish a little bit on a GLP-1. Like I find that, for instance, I eat more sweets on this GLP-1 because I think I'm seeking out stronger flavors. Despite eating the sweets, I still lose weight. So we know that when it comes to food, there is slightly less pleasure.
14:15There doesn't seem to be any consistent clinical findings. This anhedonic response extends beyond food or other kind of food-like substances, like gambling or drinking. People who are on a GLP-1 find that they have much less of a craving to drink. I actually basically hardly drink alcohol at this point, not because I had a problem with it, just because it just, I don't know, I see a beer and I'm like, eh, I'd rather have like a juice or something. So we do see that some pleasure from substances changes. This pervasive life-wide that you're describing of Sam Altman, that does not seem to be supported by the literature.
14:52And my guess is that it has something to do with other things in Sam's life, right? Like he has a very, very stressful job. He's getting attacked by Elon Musk. Ceaselessly, he's now getting sued by Apple. There might be other factors that are impacting how much he can enjoy life. but from a clinical perspective we know that it's not as pervasive as what Sam Allman would describe but we do see that the craving and the pleasure from some substances like food or alcohol does diminish
15:23James Altucher:take a quick break if you like this episode I'd really really appreciate it, it means so much to me please share it with your friends and subscribe to the podcast, email me at algatra at gmail dot com and tell me why you subscribed, thanks
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19:42James Altucher:It said you took you four or five months. Why did you stick with something for four or five months and seeing no results? I mean, I didn't see no results. I just didn't see huge results, right? I mean, I think what you're going to find now that you're well and over your illness is that you have less of a compulsion to eat, right? I mean, you'll still be hungry when your body is hungry, and you'll still eat, but it will feel like it's more of a choice than something you're being nudged to do by your brain if, in fact, you don't need that food. And I think the other thing that I saw during that period, and this gets, again, to what we know about the science of habit formation, is that for me, eating was a keystone habit.
20:21A keystone habit is this, what we found in studies is, there are some habits that when they start to change, they set off a chain reaction, right? Exercise is a great example of this. People who exercise in the morning, they find that it's easier to eat a healthy lunch the day that they exercise, right? And we all know this. There's something about your legs being kind of sore. It's easier to eat the salad than the hamburger. Studies by these two researchers in Australia also found that on the days that people exercise, they tend to use their credit cards less. They tend to procrastinate less at work.
20:55And this doesn't necessarily make any sense because there's nothing about like going for a run in the morning that makes you think like, oh, I'm going to keep my Amex in my pocket today rather than pull it out all the time. But we know that for some people, many people, exercise is a keystone habit that when the exercise habit starts, it sets off this chain reaction that changes other patterns in your life. And for many people, eating is a keystone habit. So take me as an example. So in those first three or four months, I probably lost like, I don't know, six or eight pounds, right? Let's say I lost six or eight pounds over three months, which is about right, because it takes a little while for your body to actually change, for your stomach to shrink and for you to actually stop, eat less food.
21:37But as I lost that six or eight pounds, what I found is it was easier to go running, right? Because like the less weight you're carrying on your body, the easier it is to exercise. Now that I've lost 45 pounds, like it's much easier for me to go running because I just weigh less. And so one of the things that happened is that for me, eating less food became a keystone habit that changed the exercise habits in my life. As I mentioned also, when you're on a GLP-1, and this is documented, people often have less of a craving for drinking, drinking alcohol. And that actually changed, that's actually a keystone habit as well.
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22:11Because if you think about how much of your socialization is shaped by having a drink, then oftentimes you might have, you know, I find that I have better conversations at parties, just because I'm just a little bit more like, I don't know, because I'm a little bit more sober, right? And that doesn't mean I can't have a drink. Like, I enjoy having, I still have an occasional drink. I just have fewer drinks than I used to. It also, drinking less has also changed my sleep patterns, right? Because we do know that when you drink, that it disrupts sleep, particularly it disrupts middle of the night sleep, like sort of deep sleep and REM sleep.
22:47And so as a result, because I'm drinking less, I'm actually sleeping better. And because I'm sleeping better, I'm more focused at work. And because I'm more focused at work, it's easier to get things done, et cetera, et cetera, et cetera. So one of the things that's really important is that GLP-1s allow you to influence some of the keystone habits that probably influence your life if you are using them the right way. And this gets to Noom, the company I mentioned before, and apps like it, or just some structured way of changing your habits. When you use Noom or anything else, or you just have a structure that you're using, what you can do is you can identify the habits that exist in your life, right?
23:23Identifying keystone habits is actually kind of hard. Like most people don't realize that their sleep is impacted so much by drinking. But if you have a structured system, like an app that you go to that helps you track, you know, how much did I eat today? And how did I sleep? And X, Y, and Z, just simple stuff that you can input. It can find those patterns for you. And it can say, hey, look, I just want to point something out. You only had three drinks last week. And normally you have seven drinks in a week. And you said that last week your sleep was about 30 % better. And there's probably a relationship here between what's happening with your alcohol consumption and your sleep quality.
23:59So having a structured system in place, whether it's Noom or something else, that helps you become aware of the patterns in your life, that helps you see those patterns, that seems to be critical at taking advantage of this habit window when our habits become more malleable.
24:14James Altucher:So then what begins to happen? Like you mentioned, okay, so this food noise quiets down. That's a result of the peptide, the GLP-1. And then your stomach starts to shrink. Like what else is happening in your body? Okay, so a couple of things. First of all, your stomach starts to shrink, right? Your stomach is releasing food more slowly into your intestine. And so as a result, you're feeling full. You're feeling satiated longer. Your blood sugar is, again, we don't exactly, like, I'm going to say something that's an oversimplification of what's actually happening. But basically, spikes and eddies in your blood sugar become a little bit less intense.
24:51And so as a result, you have less of that, like, afternoon exhausted after a big lunch or that like, you know, the morning when you're just like, when you're like, just hungry, hungry, hungry, that tends to go away, right? Because your glucose levels are actually stabilizing. This is why they prescribed it to you as for prediabetic conditions. So that's one thing that happens. The second thing that happens inside our brain, and this is the psychological part of it, is that we start getting into what's known as stated and revealed preferences. So you can think of us all as having basically two brains.
25:24One part of our brain is the prefrontal cortex. and it's the thing that makes decisions. It's the thing that we're in touch with and we use for thinking. And that prefrontal cortex often will set goals for itself or set intentions or preferences. It will say, I want to lose 20 pounds or I want to run a marathon. But then there's another part of our brain, the deeper interior structures of our brain, parts like the basal ganglia, which is where habits live within our cranium. And it does not pay attention to what we say we want. Rather, it pays attention to what it observes about our behavior. So you might say like, I want to lose 20 pounds and I want to run a marathon.
26:04That's your stated preference. But that deeper part of your brain is looking at revealed preferences. And what the revealed preferences show is when you woke up this morning, you did not go for a run. And when you had a choice between a salad and a hamburger in the cafeteria, you chose the hamburger. So even though you say that you want to lose weight and you want to run a marathon, I don't believe you, right? I think that based on your revealed preferences, that it turns out you actually want something different. And this tension between stated preferences and revealed preferences inside our brain, that's often what makes it hard for us to act on changing our behavior in the way that we want.
26:43So what happens when we start on a GLP-1? Well, as you start on the GLP-1 and you're feeling less of this food noise in your head, and if you're using a structured system, you're starting to change your habits a little bit, and most importantly, you're just less hungry, and so you're eating slightly less in each meal, that deeper interior part of your brain is starting to say, actually, you know what? The revealed preference here is that this person actually does want to lose weight, or this person does want to eat more healthily, or this person does want to exercise. And as that revealed preference starts to align with our stated preference, it changes our sense of identity.
27:19Our brain is like a machine that uses a sense of identity to determine how to make choices. And when that sense of identity starts to shift, when my brain starts saying, actually, you are someone who goes running in the morning. You're actually an athlete. That's when my brain starts saying when I walk into the cafeteria, actually, athletes, they don't eat hamburgers for lunch. They eat a salad for lunch. And so it becomes so much easier for me to pick up that salad and ignore the hamburger because my stated and my revealed preferences have become aligned. my sense of identity has started to change.
27:49And that's what makes habit formation permanent.
27:53James Altucher:You know, that's very interesting. It makes me think, is this part of the brain responsible for the placebo effect in the sense that, let's say I start taking some drug that, like human growth hormone, I'm going to grow muscles. I'm not taking this, but let's just say. And I start thinking to myself, oh, I'm the type of person that is jacked at the gym. And then does the placebo effect kick in? Because then the revealed preferences part of my brain says, oh, he's thinking of himself as the kind of person who's jacked at the gym, so he must be an athlete. Very likely. Very likely that's exactly what's happening, right?
28:29James Altucher:I have a very powerful placebo effect whenever I take anything. Yeah, and if you know that it's a placebo, it might not have that effect. But if you think that you're taking like an actual medication, right? In studies, when they give someone a placebo, they give them essentially a sugar pill, but they don't tell them it's a sugar pill. They tell them it's the real medication. I think that's exactly what's happening is that part of your brain is saying, oh, look, James is actually giving himself a shot once a week of a GLP-1. And if he's doing that, he must be someone who actually wants to be healthier, right?
28:58Or he wants to lose weight or he wants to eat better. And so your brain pays attention to your behaviors. And I think you're right. That's part of what influences the placebo effect. I'll say there's a lot that we don't know about the placebo effect, sort of mysterious. We don't know why it affects some people more than others. But I think that you're onto something there, that part of what's happening is that the placebo is changing our sense of identity, even if it's not changing our biology.
29:22James Altucher:It's really interesting. It reminds me of, do you know Todd Herman? He wrote a book called The Alter Ego Effect. No. So he's kind of a sports coach psychologist, and he makes the point that a lot of super athletes who are at peak performance, before they go out on the field, they kind of hypnotize themselves into taking on an alter ego. So he gives us a great example. Kobe Bryant is like the black mamba, this king of the snakes. And he talks about other athletes being like Paul Bunyan or whoever. They heavily research some alter ego and then even dress like or become that alter ego before going out on the field.
30:03James Altucher:And then they perform accordingly. And I wonder if that's also trying to program that basal ganglia part of the brain. Oh, absolutely. Absolutely. And I'm sure that if I was to look at what they do before a game, what I would see is I would see some ritualized behaviors that have become cues, right? Michael Phelps always stretches the exact same way before every single practice and every single race. And the reason why is for exactly the reasons you just mentioned. He's basically like going through this routine that's triggering these habits that allow him to perform well in the pool or give him a sense of alter ego.
30:38And I think one of the things that's important here is that it doesn't take a lot to do this, right? So one of the things that we know is that when you are trying to change habits, including food habits around GLP-1 use, it's really, really good to start small. It's really good to start with these micro habits. Again, this comes from the research that I was doing with Noom. They were looking at like when people were using the app, when did it seem to work? Like when did they seem to make these changes? And one of the things that they found is that by creating these micro habit challenges, small little contained habit challenges, rather than like this full lifestyle overhaul, that seemed to be particularly effective because the habits tend to compound on each other, right?
31:21Again, I eat a little bit less one day, then I drink a little bit less one day, I sleep a little bit better that night, it's easier for me to eat more healthily and go exercising the next day because I slept well. This chain reaction tends to become larger in our life if we start small. And so one of the things for people to think about when they're in this habit window, when they've started using a GLP-1, is how do I build the micro habits? What are the right micro habits to build? How do I build them and track them in a way that I feel like I can see this echo in my life? And so what micro habits were you building in that first four-month period?
31:59There's a bunch of them. So one of them is that I was definitely drinking less, right? I just had less of a craving to drink. I think another one is that I would often find myself sitting down at a table and there would be a basket of fries or something similar. And if you had asked me what I expected to happen, I would say I would just reach over and grab them and put them in my mouth without even really thinking about it. And then I'd get to the end of the meal and I'd realize I didn't grab any fries. I just never felt the urge to grab the fries. I will point out that just last week, I was still grabbing fries.
32:31Okay. Okay. And again, you're only three weeks into this, right? Like it takes a while for the GLP-1 to really like start influencing your body.
32:39James Altucher:But I have been feeling fuller more quickly. Yeah. So that's another important part. So like if I sat down, if you put a plate of food in front of me, I would eat the entire plate of food. And I have like one of my sons, even if it's a meal that he loves, he'll eat until he's full and then he'll just stop eating. Like he'll leave half the plate of food on the table because he's full. And like that, I, that never happened to me. Even if I felt full, I would continue eating. I just, I never, the idea of like, just kind of being like, oh, I'm done. I don't need any more, even though this thing is delicious.
33:15That just never happened inside my head until I started on a GLP one. And what I would do is I would sit down and start eating and I'd be like, I'm kind of full. I don't want anymore. And I would just stop eating. And again, this revealed preference, part of my brain was paying attention to actually, this is a guy who can resist the temptation of food. And that makes it easier to resist the temptation of food when your brain starts believing you're that kind of guy or woman. And so I think that's what I noticed in the first three or four months is that my behavior changed almost in ways that I wasn't I wasn't even having to choose.
33:50I wasn't having to use any willpower to ignore the French fries or use any willpower to put the half-eaten plate of food aside. And because I wasn't having to use any willpower, my brain paid attention to that. And it also gave me more bandwidth to build better habits, to build new and better habits, which is, you know, if I sit down, instead of ordering the really tasty but unhealthy thing on the menu, to order the healthier thing, to order the salad and to enjoy it just as much.
34:19James Altucher:Okay, and so then you're saying the stomach starts to shrink, but it could be that the stomach is shrinking because, not because of the peptide, but because if you're putting less food in there. Yeah, yeah, no, that's why it's shrinking. It's shrinking. The peptide does not influence your stomach size. Stomach size changes based on how much food you're actually consuming. So the peptide, it does the opposite of what I would think a weight loss drug would do, which is you're saying it slows down metabolism, essentially. It slows down the emptying of the stomach. Yeah. And metabolism is something that's slightly different.
34:50So like, it doesn't really matter. But anyone who's a biologist, it slows down the emptying of the stomach. That's the thing that it does that seems to have a significant impact in addition to other things.
35:00James Altucher:I would think a weight loss drug would speed up the burning of food in the stomach. Well, the problem is, I mean, speeding up the burning of food doesn't mean that those calories are getting consumed into energy, right? Like, yeah, so like, so like the, basically what you're trying to do, I mean, look, there's a basic math to weight loss, which is the less you eat, and the more calories you burn, the fewer excess calories you'll store as fat. And so what we're trying to do is we're trying not necessarily to like change how quickly you're burning up calories. We're trying to influence you in a way that you eat less.
35:40Because if you eat less, and particularly if you keep your energy levels as they were before, or even better if you increase them, because now you're exercising and you're lifting weights and trying to put on more muscle mass, instead of those excess calories going into fat, you just have fewer excess calories. And so as a result, you're kind of at this place where your weight maintenance is easy because you're basically burning all the calories that you are taking in as food when you take them in and they're powering you through the day.
36:09James Altucher:and so what happens at the four to six month part where suddenly it's like boom you're flushing the calories out so i don't think you're flushing the calories out i think what's happening is that in four to six months like your habits have actually changed right so there's a couple things going on first of all your stomach has shrunk because you've been eating less food and as a result you're less hungry and because you're less hungry it's easier for you to maintain like a healthy amount of food a healthy a healthy diet in addition i think oftentimes your your blood sugar has stabilized at that point.
36:39And so you're feeling less of those cravings in the morning and that post-lunch lethargy that's been influenced. And then I think the other thing that's happening is that these habits have started to change. Some of the habit changes happen without you even realizing them, right? Like again, if you're in this habit window, when your habits are more malleable, some of them will shift because your brain starts to notice, oh, he doesn't grab for the French fries. The food noise, which is the cue for eating, has been quieted somewhat. And so as a result, you're starting to execute on these new habits that you're building without you even realizing it.
37:11And I think that's what happens is that you get like all of these things on their own, they cause weight loss. If you want to lose weight, you'll start losing weight probably like this month or next month on the GLP-1. But the point at which like it starts to really become noticeable, like you see the change in your body and you see the change in the shape of your face, that just takes a couple of months because for one thing, you just got to lose some of the baby fat, right? Like you don't really see the shift until you've lost enough weight
37:41James Altucher:that you can see the shift. And that must be reinforcing to that basal ganglia, which is now it's saying, oh, he really is the type of person to lose weight. Absolutely. And it's not only the identity that's been shifting, but now that I weigh 20 pounds less, I find that it's easier to go running in the morning. And so therefore I run more in the morning. And that means I'm actually exercising more, and that improves my muscle tone, and that helps me keep off the weight, and I'm feeling healthier about myself. They all become reinforcing of each other.
38:28James Altucher:Do you stay on the GLP-1s? Is it like a lifelong drug? Okay, so here's what we know. And I keep on mentioning Noom, but a lot of this is just because it's the research that I'm familiar with. So, like, Noom did a study basically trying to figure out, like, do people have to stay on GLP-1s? Because you can actually get, you can get micro doses or macro doses of GLP-1s from Noom. They'll prescribe them to you, and then they'll give you the habit change system. And so they're able to observe what should happen. And what they find is that if you do not have a habits change structure around you, Most people at some point want to discontinue taking the GLP-1, either because they don't like giving themselves a shot every week or because it gets too expensive or they're traveling a lot more and it's just like hard for their lifestyle.
39:14So what we know is that the majority of people end up discontinuing GLP-1 use sometime in the two years after they start. And if you don't have a habit structure in place, it's very common that as soon as you discontinue the GLP-1, you start regaining the lost weight. And the reason why is because that food noise comes roaring back and you don't have any new habits. But if you do have this habit structure in place, if you've taken advantage of this habit window and you've built new habits, deliberate habits, where you're choosing, okay, here's the cue. Who's the routine? Here's the reward. I'm monitoring and I'm measuring if I'm actually doing this.
39:51I'm making little adjustments because I have this thing that helps me observe my own behavior and learn from it. If you've built these new habits, then you tend to keep off the weight much, much longer after you discontinue the medication. In fact, up to two years, we only have data basically up to two years, but a good number of people actually keep the weight off for those entire two years after they discontinue the GLP-1 because they have this new set of habits that they have built while they were on the GLP-1 itself.
40:21James Altucher:So I'm going to argue that a healthy thing would be to, when you first go on the GLP-1s, and I'm just talking about my own experience of this, I did not go on with the purpose to specifically to lose weight, but I got really paranoid that the word pre-diabetes showed up in this blood work. And this is like a pre-diabetes drug. And so I'm telling myself I'm doing this for my health. and that I'm the type of person who cares about themselves. So that's why I'm taking this. And I think I'm hoping that helps me with the kind of long-term habit formation, just that attitude. Yeah, so I think that attitude is a good attitude, but it's not sufficient on its own.
41:05You need a structure. Like you need a structure to help you understand your own habits, identify your habits. You need something that nudges you to change them a little bit, to track whether that change was actually effective.
41:17James Altucher:kids in the house and kids eat food and, you know, they eat breakfast, lunch, dinner, which is hard when you're older. How did your house change around the fact that you were forming these new habits? I mean, it didn't, it didn't change my wife or my kids' habits at all. Before I started a GLP-1, I would wake up every morning and I would have like a bowl of granola with blueberries on it. And oftentimes after I'd eat that bowl of granola, I was like, that's really, really yummy. I want a second bowl of granola and I'd have the second bowl of granola. And now when I wake up and like Like, I'm like, should I have the bowl of granola or should I have like the protein shake?
41:49And I'm like, I'll just have the protein shake. Like, that seems just as good. And I have the protein shake and I'm sort of satisfied by the protein shake. And so instead of having a bowl of granola, I'm having a protein shake. But I'm still sitting down with my kids and having breakfast with them, right? Like, it's not like they're still having granola. They like, or they don't actually like granola. They like other stuff like Cheerios and like nonsense cereals. So it hasn't really impacted. My family's food selection has not changed significantly. what I'm eating from that food selection has shifted a little bit, but more importantly, the amount that I'm eating has shifted.
42:23So I would not say that it's like something that's been disruptive for my family. I mean, what we're really talking about is just how do you curb some of the cravings? Now, I will mention, you mentioned pre-diabetic, that you did this for reasons of pre-diabetes and not weightless. So those are actually inexorably linked. I'm certain that if I was to look at your lab results, what I would see is I'd see that your doctors are saying that they feel like you might be slightly pre-diabetic because A, you're a little bit heavier than you should be. And particularly if they're measuring percent body fat versus percent muscle mass, that ratio is a little bit out of whack, right?
42:57So losing weight isn't really the goal. The goal is to have a healthy level of fat versus muscle. So actually, at this point, my weight has not decreased in a year, but I've put on more muscle mass and I've lost more body fat. And so as a result. My weight's the same, but it's like healthier weight. So one of the things that they're probably looking at is body composition. They're probably also looking at your blood chemistry and your blood chemistry is telling them that you might have too high a level of cholesterol or something like that. Something that's suggesting why they should think about prediabetes.
43:27And that is kind of weight related. So it's not really about necessarily what the scale tells you, but your weight and prediabetes are interoperably linked. Right.
43:38James Altucher:There was something in the blood. I forget what it was. Something related to insulin or something. Yeah, insulin resistance, probably. Sometimes they call it metabolic syndrome, where basically you become more resistant to insulin. And as a result, it's harder for your body to stabilize your blood glucose levels and the hunger pangs that are associated with them. Yeah. And this somehow is related to the terzep. So there's three types of GLP-1s as far as I know. There's the azempic kind, there's the trisepatide, and then there's this super one, that retro... Yeah. I don't know how to say it. So there's semiglutide, there's trisepatide, and then there's the new retro.
44:18Sometimes they call it a GLP-3 because it actually seems to affect three receptors.
44:24James Altucher:And trisepatide affects two receptors as opposed to azempic, which is one. I believe that's right. I think that's probably an oversimplification. But yes, the medications, they all have the same origin, which interestingly is the saliva of a heli lizard. That's how we discovered GLP-1s was from the saliva of a heli lizard. Because heli lizards can basically like stop their metabolism for weeks or months. And a researcher wanted to understand why. They all sort of come from the same, it's all the same basic mechanism, but they have slightly different ways in which the mechanism unfolds. So, okay.
45:01James Altucher:So after the four to six months, your stomach has shrunk enough, your habits are formed, so you start losing weight. And again, you're losing weight before the four to six months, right? Right. But the truth is that, like, if you lost four pounds this month, you wouldn't feel or look that different. Right. But if you lose... Normal volatility. Yeah. If you lose 20 pounds over five weeks, which is four pounds per week, at the end of that 20 pounds, you're going to look and feel different, right? You're going to look in the mirror and you're going to say, like, oh, I look thinner, and it's easier to go running in the morning.
45:32So it's not so much that like the drug is ineffective at the beginning. It's that it's when you start to see the real impacts because of cumulative effect that the habit change seems more real. So will you stop using the GLP-1? Yeah. I don't know. It's a really good question. I mean, I find it very easy to maintain right now, and I take a relatively low dose, and I enjoy not having that food noise in my head. But yeah, Yeah, at some point. I mean, I do find that what happens, the truth is that actually I stop all the time. Like, because the GLP-1 has to be refrigerated, if you're traveling a lot, it's very hard to sort of carry it with you.
46:10And so, for instance, me and my wife, we just went on vacation together. And so I basically didn't take it for a week and a half because we were on vacation and I couldn't keep medication that has to be refrigerated with me for a week and a half. At some point, I probably will discontinue taking it. But what is important is that I get to feel like it's a choice, right? That like I get to decide how much I want to weigh. I get to decide how physically active I want to be. And that it's the decision that reinforces that behavior.
46:41James Altucher:Have you checked other markers? Like, you know, there's tests for your biological age and things like that? Yeah, yeah, yeah. No, I get blood work done like basically every eight weeks. So pre-GLP1 to now, how has your biological age changed? Everything's better. I don't get my biological age measured, but I do know that like, like I look at like, you know, ALT, like all the different levels of sort of the CBC that you usually get when you get a blood work plus some additional things like PSA. All of that has gotten better. So like, so basically like I was, I would say I was out of compliance in about, I don't know, probably a third of my blood tests.
47:20And I'm in compliance now for all of my blood tests. But equally importantly, before I started on the GOP-1, I would snore. And like my wife would say, like you were snoring last night. And I would wake up and I would have that kind of like, you know, that sore throat that you get from snoring sometimes. That's completely gone. Like because I've lost weight, I've stopped snoring. So yeah, in general, I would say like this has actually been like a huge health benefit for me. My cholesterol levels are better. All of my numbers have gotten better.
47:48James Altucher:You know, it's so funny because it's all related to this almost philosophical issue about who are we? What is our identity? If your prefrontal cortex says, oh, I want to have these goals. I want to lose weight. And then your other parts of your brain are saying, oh no, but that's not what your actions are. You really want this. So I'm going to do this for you. And then the drug comes in and sort of tries to moderate this fight. It's all these different parties involved in making up this question of who we are. Yeah, absolutely. You know, and then the idea that in our brain really is just, you know, a neuron firing is just an electrical impulse.
48:31James Altucher:And now, you know, Roger Penrose wins the Nobel Prize for saying, you know, consciousness is actually this quantum artifacts that happen outside of our brain. It's all these, you know, we're just kind of this hodgepodge of chemicals and quanta and electrical signals. Yeah. And then, And then, of course, weight affects us, and alcohol affects us, and smoking affects us. That's exactly right. So think about just sugar, right? So sugar actually influences how we think about ourselves because it gives us more energy. So one of the reasons why people like sugar is, first of all, our taste receptors sort of find some pleasure from it.
49:07But you can get that same taste receptor. If you take Splenda and you spread it across your tongue, you'll get the same taste receptor experience that you get with sugar. So why do people like sugar instead of Splenda? It's because it gives us this energy. It's very calorie dense. And in fact, it's a type of calories and a type of energy that hits our blood system very, very quickly. And so as a result, we get this little boost of like, oh, I've got more energy and that feels good. So we've been influencing our behavior and our self-concept with food and drink and all kinds of things for essentially since we evolved to be human.
49:43What's different now is that we just understand more about how it works. We can be more deliberate about it. And we can understand and recognize these opportunities to change the behaviors in our life, to change the habits in our lives in a way that makes them sustainable even when the sugar ends or the GLP-1 ends or we drink fewer drinks. We can choose to be the person we want to be rather than relying on the influence of outside substances.
50:09James Altucher:Well, Charles, this has been great. And of course, you're the first person I wanted to talk to about this. You're obviously the author of the huge bestselling book, Power of Habit, Charles Duhigg, and also the book, Super Communicators, which we've spoken about. And I'm just beginning on this peptide slash GLP-1 journey. I've been taking other peptides, but I'll talk about that some other time. But the GLP-1s have been described to me as a miracle drug, and I'm just beginning it and trying to understand. And like I said, I had the misfortune of thinking they had kicked in full force when my stomach exploded last week.
50:46James Altucher:But that turns out to have been a side effect of getting COVID. But I think I lost about 12 pounds that day anyway. Oh my gosh. Yeah, yeah. Well, let me know how it goes. First of all, thank you for having me on. It's always like such a treat to get a chance to talk to you and spend some time with you. But secondly, like, let me know how it goes. And in fact, I will advise, it's worth keeping, whether it's through Noom or another app or just a food journal, it's worth keeping track of what you're feeling and how your behavior is changing. Because I think what you're going to see is oftentimes we don't recognize behavior change as it occurs unless we're actually forcing ourselves to pay attention to it.
51:27And so my guess is that over the next two or three or four months, you're going to see more behavior change than you would have noticed just on your own if you weren't tracking it.
51:36James Altucher:And I have noticed some things, but A, I think the placebo effect is very strong with me. Like as soon as I take something, all the symptoms work immediately on me, even though that's not supposed to happen, like as I'm so excited. But also, and then combined with that, I got this COVID, which does this extreme effect on your body. So like when I didn't want to finish a meal, the other day, it could have totally been a result of being incredibly sick. Yeah. But I would say now, I'm three weeks in, I'm getting over this virus, and now we'll really start to see. Yeah. We'll have you on in like six months, and we'll see if I'm on that.
52:12James Altucher:I love it. Keep me updated. I want to know how it goes. Definitely. All right. Thanks so much, Charles. I appreciate it. Thank you.
52:50James Altucher:IoT Show
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From the publisher
A Note from James:
I’m doing a big experiment in my life.
I recently started taking a GLP-1—tirzepatide, one of the so-called weight-loss drugs. But I didn’t start taking it specifically for weight loss. I had some blood work done for the first time in a long time, and there was a small indication that I might be pre-diabetic. My doctor suggested trying tirzepatide, and I wanted to understand what I was getting into.
The first person I wanted to talk to was Charles Duhigg, author of The Power of Habit and Supercommunicators. Charles has been taking a GLP-1 for about two years, and he says it has changed his life. He has lost around 45 pounds, but what interested me most was not just the weight loss. It was the habit change.
Charles explains that GLP-1s can quiet what people now call “food noise”—the constant background pull toward eating even when you are not actually hungry. When that noise quiets down, something interesting happens: you get a window where your old habits become more malleable.
That is the key idea of this conversation. The drug may help you eat less, but the bigger opportunity is that it gives you a chance to build new routines around food, exercise, alcohol, sleep, and identity. And if you build those habits while the window is open, those habits may continue even after you stop taking the medication.
We talk about food noise, cravings, the habit loop, keystone habits, stated versus revealed preferences, placebo effects, alcohol, sleep, exercise, blood sugar, identity, and whether GLP-1s are a lifelong drug or a tool for changing who you become.
Episode Description:
James is at the beginning of a GLP-1 experiment. Charles Duhigg is two years in.
In this conversation, Charles explains what he has learned from taking tirzepatide and from studying GLP-1s through the lens of habit formation. He describes the first phase of public understanding around these medications as weight loss. Phase two, he argues, is about behavior change.
The central concept is “food noise.” Charles describes it as the background craving that turns a basket of fries into an almost automatic behavior. You may not even notice the noise until it goes away. Once it quiets, the cue that normally triggers the habit loop weakens. That creates a temporary window where new habits can be built.
James and Charles use the GLP-1 experience to revisit the basic habit loop: cue, routine, reward. They talk about why habits feel automatic, why willpower is often the wrong tool, and why successful behavior change depends on identifying the cue and replacing the routine while still satisfying the underlying reward.
Charles also introduces the idea of GLP-1s as a catalyst for keystone habits. Eating less can make exercise easier. Drinking less can improve sleep. Better sleep can improve focus. Focus can improve work. One changed habit can set off a chain reaction.
The conversation then becomes more philosophical: Who are we if one part of the brain says “I want to be healthy,” while another part of the brain keeps revealing different preferences through action? Charles explains the difference between stated preferences and revealed preferences, and how repeated behavior can shift identity.
This is not a conversation about taking GLP-1s casually. It is a conversation about using a medical intervention deliberately, under appropriate medical guidance, as a chance to change the patterns that shape daily life.
Editorial Note:
This episode discusses prescription medications, including tirzepatide and semaglutide, as well as personal experiences with GLP-1 drugs. It should not be treated as medical advice.
GLP-1 medications can have side effects and risks, including gastrointestinal symptoms, dosing concerns, and contraindications for some patients. They should be used only under the supervision of a qualified medical professional. Any decision to start, stop, adjust, or combine medications should be made with a clinician.
James and Charles also discuss personal experience, habit change, appetite, alcohol cravings, and identity. Individual responses to these medications vary.
What You’ll Learn:
- Why Charles believes GLP-1s are entering “phase two”: not just weight loss, but habit change.
- What “food noise” feels like—and why people often do not notice it until it disappears.
- How GLP-1s may create a temporary “habit window” where old routines become easier to change.
- Why the habit loop—cue, routine, reward—matters when trying to change eating behavior.
- Why people often regain weight after stopping GLP-1s if they have not built new habits.
- How keystone habits can create a chain reaction across food, exercise, alcohol, sleep, and focus.
- Why micro habits may work better than a full lifestyle overhaul.
- How stated preferences and revealed preferences shape identity.
- Why eating less can make exercise easier, and why exercise can reinforce healthier choices.
- Why tracking behavior may be essential while taking a GLP-1.
- How placebo, alter egos, and rituals may influence identity and performance.
- Why the goal is not just losing weight, but becoming the kind of person whose habits support health.
Timestamped Chapters:
[03:36] James Begins His GLP-1 Experiment
James explains his early experience, including confusion between medication side effects and a bout of COVID.
[04:16] Charles’s Two-Year Experience
Charles describes taking tirzepatide, losing roughly 45 pounds, and why the biggest changes came months into the process.
[05:38] Phase One vs. Phase Two of GLP-1s
Phase one was about appetite and weight loss. Phase two, Charles argues, is about habits that can last.
[06:42] The Habit Window
How GLP-1s can quiet food noise and create a period where eating habits become more malleable.
[07:21] COVID, Side Effects, and Early Signals
James explains why his first few weeks were hard to interpret and why he is still figuring out what the medication is doing.
[09:00] What Food Noise Actually Feels Like
Charles uses the example of a basket of fries to explain cravings, cues, and automatic eating.
[09:55] The Habit Loop: Cue, Routine, Reward
Charles revisits the framework from The Power of Habit and applies it directly to food cravings.
[10:42] How GLP-1s Interrupt the Cue
The fries are still there, but the craving does not activate in the same way.
[11:40] What GLP-1s Do in the Body and Brain
Charles explains what researchers know about gastric emptying, glucagon-like peptides, and what remains uncertain about the brain.
[12:43] What Happens When You Stop
Why the medication alone may not be enough if old habits return after discontinuation.
[13:36] Pleasure, Food, Alcohol, and Anhedonia
Charles discusses reduced pleasure from food and alcohol, while separating clinical findings from broader claims about losing joy in life.
[15:54] Why Charles Stayed With It
Early changes were not dramatic weight loss, but a growing feeling that eating became more of a choice.
[16:40] Eating as a Keystone Habit
How changing food behavior can trigger changes in exercise, alcohol, sleep, focus, and work.
[19:31] Why Structure Matters
Charles explains why tracking and guided habit systems can help people see patterns they might miss on their own.
[20:32] What Changes Physically Over Time
Slower stomach emptying, feeling full longer, more stable blood sugar, and gradual changes in appetite.
[21:43] Stated Preferences vs. Revealed Preferences
Why one part of the brain says “I want to change,” while another part watches what you actually do.
[23:22] Identity Change and Habit Formation
How repeated behavior can teach the brain, “I am the kind of person who eats this way” or “I am the kind of person who exercises.”
[24:16] Placebo, Belief, and Becoming the Person You Want to Be
James and Charles explore whether placebo effects may work partly by changing identity.
[28:07] Alter Egos, Athletes, and Rituals
The conversation turns to Kobe Bryant, Michael Phelps, and how pre-performance routines can cue a desired identity.
[29:15] Start With Micro Habits
Charles explains why small behavior changes can compound more effectively than trying to overhaul an entire life at once.
[30:40] Charles’s First Micro Habits
Drinking less, eating fewer fries, stopping when full, and choosing healthier meals without relying on willpower.
[31:24] Feeling Full for the First Time
Charles describes the surprising experience of leaving food unfinished because his body had had enough.
[33:03] Why the Stomach Shrinks
The medication does not shrink the stomach directly; eating less over time changes how much food the body expects.
[33:21] Why Slower Stomach Emptying Helps
James asks why a weight-loss drug would slow digestion instead of speeding metabolism.
[35:00] The Cumulative Effect
Why the most visible changes often appear after several months, once habits, body size, and identity begin reinforcing each other.
[37:03] Is a GLP-1 a Lifelong Drug?
Charles explains what research and personal experience suggest about stopping, restarting, and maintaining results.
[38:56] James’s Health Motivation
James explains that his motivation is not primarily weight loss, but a desire to respond to possible pre-diabetic markers.
[39:36] Why Attitude Is Not Enough
Charles argues that wanting to be healthy helps, but habit change still requires structure.
[40:02] What Changed at Home
Charles explains how his family’s food did not need to change, even though his own choices and portions did.
[41:02] Weight, Body Composition, and Pre-Diabetes
Why blood sugar, insulin resistance, fat, and muscle matter more than the scale alone.
[42:38] Semaglutide, Tirzepatide, and What Comes Next
James and Charles compare different GLP-1 medications and discuss how newer drugs may work through multiple receptors.
[44:27] Will Charles Stop Taking It?
Charles explains why he may eventually discontinue the medication, but values having more choice over weight and behavior.
[45:24] Blood Work, Snoring, and Health Markers
Charles describes improvements in lab results, cholesterol, snoring, and overall health.
[46:31] Who Are We, Really?
James and Charles talk about identity, brain chemistry, sugar, alcohol, cravings, and the substances that shape behavior.
[48:32] Choosing the Person You Want to Become
Charles explains how better self-awareness can help people change habits deliberately rather than being pulled by cravings.
[49:00] Tracking the Experiment
Charles advises James to track food, feelings, and behavior so he can notice changes that might otherwise be invisible.
Additional Resources:
- Charles Duhigg Official Website
- The Power of Habit by Charles Duhigg
- Supercommunicators by Charles Duhigg
- Noom’s GLP-1 Companion / Habit Formation Announcement
- FDA: Zepbound Approval for Chronic Weight Management
- FDA: Concerns With Unapproved GLP-1 Drugs Used for Weight Loss
- BMJ: Weight Regain After Stopping Weight-Loss Medication
- Todd Herman — The Alter Ego Effect
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