Peter Diamandis: How to Harness the Power of Mindset in The Longevity Guidebook

30:15And I said, come along, meet Richard, but we're going to go through Orlando. Why don't you go through the Fountain Life Center? And he did. He and his wife went through for an Apex. It's our membership level upload. And went to Necker. We come back on Monday. He gets a call from our physician, and he's been open about this. and the physician says, listen, Sam, we discovered two brain aneurysms and they need immediate attention. Now, Sam is someone who has afforded and had the best doctors out there, but he was in surgery a week later and these blood vessel aneurysms where a blood vessel is growing in size and could burst were basically resected and stabilized, and he's fine now.

31:17But that's an example. We have countless people where we find a stage one or stage two carcinoma or severe cardiomyopathy, cardiovascular disease. And here are the numbers. 2 % of people coming through who they claim they are completely healthy, 2 % have a cancer. They don't know about. 2.5 % have an aneurysm. They don't know about. 14.4 % have either cardiovascular, neurodegenerative, or metabolic disease. And so, you know, for me... And these diseases are sufficient enough that they need action taken upon them. Yes, yeah. These are all actionable. These are all need to take action on. The 14.4 % of people, we put them into an urgent track for addressing these things.

32:12And by the way, there is something you can do for almost everything. Even Alzheimer's and dementia, if you know early enough, you can slow it and reverse it. There's incredible work being done in that area.

32:40When I see companies like this, like Fountain Life, I always wonder why isn't, if I go to the Mayo Clinic and say, do all the tests on me, how come they don't just give me your test? And also do insurance companies pay for it? Why isn't insurance companies requiring everybody? I'm so pissed at insurance companies. I think insurance is one of the most perverse industries out there. You know, so, you know, life insurance pays your next to kin after you're dead, right? Health insurance pays you after you're sick. A fire insurance pays you after your house is burned down. Imagine if the insure, I just had a whole podcast on this on my Moonshots podcast.

33:21Imagine if the insurance industry flipped. And when I buy fire insurance, the insurance industry is going to prevent my house from burning down. It's going to put in the appropriate systems. Life insurance keeps me alive as long as feasible. Health insurance is focused on keeping me healthy because the economics for them are massively beneficial, as you just said. Well, one thing they can do to really fit nicely without changing their business model is they can say, look, we'll give you$5 billion worth of life insurance for X dollars, but it'll be even cheaper if you first go through the Fountain Life program and you have a receipt.

34:04I agree. I agree. Because then they don't have to do anything different. They just make their standards. You have to help them to help you, in other words. So if you're a life and health insurance executive out there listening to this podcast, reach out to us. You know, it's a crazy, crazy business. Eventually, we'll get there. How about we start a life insurance company or a health insurance company where we make this a requirement? Yeah, I think I love the life insurance is where I'd go first, for sure, because you're both on the same sides. Imagine when you're paying out, where you're paying into a life insurance policy.

34:43If you delay the payout, the capital in the policy is exponentially growing. Yeah. It works amazingly well. It's a great business model. It is. It's a head, a life insurance company is a hedge fund where you get to keep 100 % of the profits instead of 20 % of the profits. And the person living longer is super happy. Right. But it reminds me of like Geico in the 50s, which was set up to provide car insurance for ex-military because it turned out ex-military got into fewer accidents. So here's a case where, okay, we'll set up a life insurance company for people who have gone through fountain life because they're going to die longer away.

35:26Yep. Here's the idea number one from this. All right. Well, yes. Yes. I mean, that is definitively something I am excited about. But why doesn't the Mayo Clinic tell their patients, hey, go down to check this fountain life out? Well, listen, here's the challenge. Medicine is an old school business. And it is very slow to change. There was a study done. And Tony and I reported on it in our book, Life Force, which we jointly authored and had a chance to discuss on your show. But I think the average is like the 17-year delay between when something is discovered and rolled out and it's adopted finally by medicine.

36:22There's a great example. Human physicians are very biased. Here's a beautiful example. There was a study recently done, this is probably within the last two months, at doctors using AI chatbots for diagnostics. So the doctor by themselves had 85 % accuracy on these diagnostics. And these are rough numbers for approximation, or call it 80 % accuracy. The doctor plus an AI chatbot together had 85%. The AI chatbot by themselves without the doctor had 95%. And you say, like, why is that? What's going on? Well, humans inject a lot of bias because of their preconceived notions. While AIs are just show me the data.

37:19I'll make the decision just on the data, not, you know, a recency bias, you know, these all these cognitive biases, recency bias of like I just saw this patient who had this particular syndrome. So I'm more likely to think of it again. it's slow and and you need sometimes to begin institutions just like you know why isn't why didn't intel uh become nvidia or why didn't you know pick your favorite software company become open ai it's like a lot of times uh you have to start with a clean sheet of paper to reinvent yourself and so you think the medical industry will have to do that so what's going to happen is patients, instead of going to their family doctor, will start just going directly to Fountain Life and taking action.

38:08And we do, we do offer, I mean, so when, when you join Fountain Life, not only do we give you the full upload, right? You know, this 200 gigabyte data set that's uploaded into the app, into our, into our cloud. We also give you a medical team that surrounds you. So you get a concierge doctor for the year. You get a concierge nurse, a dietician, and a health coach. And so that team is with you through the year to help you achieve your medical objectives. So it is your direct doctor. I used to spend$20 ,000 on a concierge doctor here in LA who didn't offer all the other stuff. It's still expensive.

38:54The price of these things will come down. We offered a version of this called Core. So Apex is$19 ,500. Core is$6 ,500, which is all the same testing, but without the wraparound medical team for the year. And people can go to feltinlife.com to learn more about it. Where we're going, James, in the future, I think is super exciting. And we're going to eventually get to a point where we are constantly monitoring everything going on in our bodies, that we're monitoring everything through a series of sensors, right? I've got my Oura ring. I normally am wearing a continuous glucose monitor on my Apple Watch, but that's just the beginning.

39:41Eventually, a series of embedded sensors on your body, in your body, in your environment, are measuring everything all the time and being able to look at small perturbations. Maybe it's the sound of your cough. Maybe it's when you're using the toilet, the data is being extracted from, you know, when you go through the restroom. And when will that happen? Because I keep hearing this and it's not like I'm downing it because something's in the future because it's hard to do now. But when will our daily lives change? Because, yes, we will have more monitoring than just the Oura Ring or the Apple Watch or whatever.

40:23I think it's within the next three years at the outmost because we're seeing GPT-5. It's going to come online. We just saw Grok 3. We'll see a version of Claude 4 and whatever Alexa becomes. Um, and all of these systems will be, you'll turn on health monitoring mode. Um, and I cannot imagine it's more than three years out. Uh, uh, but this will become sort of a continuous layer of always on health monitoring, uh, that I think will support you in really, if you want to maximize your health, you'll have that ability. I think what gets interesting is it will also integrate with your kitchen and be able to tell you what foods you need to maximize your health.

41:28I mean, that sounds fun for me. And who's working on, like, where am I going to first see this device that will do kind of more inclusive monitoring than currently exists? So my venture fund, Bold Capital, has investments into a number of wearables and implantables that are doing advanced monitoring of your body. We will see, I'm sure, you know, Apple. Tim Cook said a few years back, in the future, looking backwards, Apple will be viewed as a health company, gathering health data. So there's probably hundreds of small companies, and there'll be aggregation plays. I'd be surprised if we didn't see companies like Samsung get into this business and others.

42:24So it's very interesting. So when I mentioned the non-common sense parts of longevity, you went to prevention. Events testing. Yeah. Yeah. But there's also this idea, and I think people kind of lean towards this a little bit more, for better or for worse, that, oh, I'm going to take a pill and it's going to make me better than a better human being than I was before. Like the limitless pill in that movie with Bradley Cooper. And you mentioned it. Love that movie. I know. I've seen it like five times. But you mentioned in the book, there's things like NMN, Modifinol, Rapamycin. I don't know if I'm pronouncing them right.

43:04But NMN is one that I've on and off taken for whatever, since six or seven years since I first interviewed David Sinclair. And, you know, does it make a difference? I can never really tell. Right. Yeah. So the question I always ask is, is it visceral? Do you feel different? Do you have more energy, more mental clarity, right? And listen, I have a very clear understanding of how NMN impacts your cells and your body, and it makes total logical sense. David Sinclair, in his book Lifespan, does a beautiful job of explaining why nicotinamide, tinamide, mononucleotide, NMN impacts your NAD plus levels that allows your sirtuin genes and proteins to keep your DNA properly repaired from damage and allows your epigenetic systems to maintain the right genes on or right genes off and balance that.

44:14And so he lays it all out there. And at the end of the day, you can go the next step. And there's a company called Gefinity. I just got the testing to measure my NAD levels intracellularly, to understand what are my NAD levels. Because NAD is the sort of currency molecule in the cell that is fueling chemical reactions required to make things happen. And as we grow older, our NAD levels fall by 50%. And so you want to supplement them. And so I'm always very clear. I take, as I report in the book, I say 75 supplements. I think I'm probably taking closer to 85 supplements. And I am testing myself regularly, right?

45:10And just taking it and hoping is not a strategy. It's like I need to test and understand, am I impacting the numbers? So I'm an extreme on that front. It's not for everybody, but I'm sharing the knowledge that I get. And I think this is going to become something that's available for everybody with AI entering the picture, which will measure things constantly and tell you, listen, you're low in vitamin D. I've increased that as in your evening meal tonight. That's where I hope we're going to get to soon. And like taking NMN as an example, because that's probably the supplement I've most frequently have taken since beginning this journey of talking to so many anti-aging specialists.

46:01Like, have you seen in your tests the results? Like, I don't viscerally see them, but I've read, you know talked to david many times talked to the new science guys a lot and i believe the story and the science but i don't viscerally notice anything have you seen from the test so i i have not uh viscerally noticed it i literally have the gifinity tests in a box uh next to my bedroom uh and so i will it's on my list of my next blood drawer to to actually test myself yeah you know and also So there's also some controversy in some of them. Like I just saw Brian Johnson said that he stopped taking rapamycin, for instance, which has always had controversy around it anyway.

46:43But that's been considered kind of a leading anti-aging drug. It has been, I think. And I write about rapamycin in the book as one of the drugs that the most scientists feel could make a dent in human aging. And I go on and off rapamycin on a cycle. I'm off it right now. And there are seven human trials going on in rapamycin right now to actually find out, is it impacting and slowing human aging? So I'll give you one other test that I write about in the book, James, comes from a company called Immunus. A guy named Hans Kirstead is the CEO of Immunus. He's run and successfully built four companies, biotech companies, each one getting more and more successful financially.

47:42This is his fifth full disclosure. I'm an investor and an advisor in it. And I am going to be trying their treatment within the next 30 days. I just was texting with him today. And so they have created a product called Immuna. Immuna is derived, is the exudate. It's all of the immune, it's all of the exosomes and growth factors that young stem cells put out. There are 440 of them that he characterized. And he turned this into a drug where the injectable has all 440 of these growth factors and signaling molecules and exosomes in it. and he just released the results of his phase one 2a and he did this in 18 adults who had severe osteoarthritis that means they had a lot of pain and couldn't walk and they were bedridden or chair or chair ridden and the results of this were amazing first of all all 18 had no negative consequences.

48:56These people who were not exercising, they weren't even walking, gained 6 % muscle mass during the course of the three-month study. They reduced their pain by 70%. They reduced their immune age by 30 years, and they reduced their whole body inflammation by half. And what's extraordinary is what these cells are, what this product Immuno is doing is it's signaling to your body that you're in a youthful state and you should express the immune factors and the inflammatory factors that you had when you were younger. And so this is now going into an expanded use study. um uh all of our apex members will gain access to the immunostudy at no additional cost so i'm excited for that yeah when you say you're going in to for the procedure or the trial or whatever is it blind like you know you're going to be taking i do know i do know that i'll be taking it the the expanded study doesn't require a double blind there will be parts of the study elsewhere which are double blind.

50:12But I will be measuring everything in detail before, during, and after when I'm going through this. And so you're saying it's part of that. Like, can I sign up for Apex and then take the Immunasys protocol or whatever? You could. You could. Okay. I cannot make that offer that if you sign up, you'll do this. But I'm saying we are making this accessible to all Apex members. And they don't have to complete the trials for them to be able to offer this? It's available. We're going through our Institutional Review Board IRB approvals in the next month, and then it will become, will be one of the trial sites for them for the expanded access use.

51:00and so one of the things that we're looking to do at Fountain is find the longevity related therapeutics that have the highest reward, lowest risk in which we can make those accessible to our members. Our members are very highly characterized. We know a lot about them and so it's a good partnership with people who are doing therapeutic development.

51:41And so these are the sorts of things where I feel this escape velocity is going to happen. And yet I give you another one, even bigger. Yeah. So I think you mentioned this slightly at the beginning of the show. So, you know, a year ago, we announced a$101 million HealthSpan XPRIZE. So what does this mean? So XPRIZE Foundation, I started 30 years ago, and we've launched 30 XPRIZEs in 30 years, about$600 million worth of incentive competitions. The first one was for spaceflight. And we said, okay, anybody who builds a private spaceship that can fly three adults up 100 kilometers, land, and do it again within two weeks wins$10 million.

52:30And launched that under the arch in St. Louis in 1996. It was won in 2004. That ship over my shoulder in this video is the winning vehicle. And it stars the races. You know, Elon Musk joined our board and Larry Page joined our board and James Cameron joined our board. And we set out to run these large scale global competitions, not for a design idea, not for something you did in the past. It was like we set a goal, an incentive prize. And if you if you pulled it off, no matter where you lived, how old you were, what you've ever done before, if you solve and demonstrate and build it, you win. And so that's an X prize.

53:11And a year ago, November of 2023 specifically, so a little bit over a year, we announced a$101 million XPRIZE healthspan. Sergey Young, who you've interviewed, was part of our founding team and funded the original design work here. It took me five years to raise the money. I raised$141 million. And this is for a therapeutic that can, in one year's time, giving the therapy to someone for no more than a year, do it for a day, but no more than a year, will reverse the ravages of aging in your immune system, your muscles, and your cognition by 20 years. So what we need to do is make your immune system that of what you were 20 years younger, your musculability, build muscle, your cognitive clarity.

54:06And we have over 600 teams in this competition in just a year. And are the teams companies or are they academics or combination? They're everything. They're academics. They're companies, small, large companies. And there are some absolutely brilliant solutions. And what's interesting is, are all these things in the same category? Will some solution that makes my lungs younger or my heart younger also work on my cognitive clarity? Why would that be the case that would all fit under one solution? So this was a conversation early on with George Church at Harvard Medical School who said, listen, a true age reversal therapy will not just hit one organ system.

54:55And so if you have something that impacts immune muscle and cognition, it's likely to also impact lots of other systems in the body. Aging is the underlying biochemistry of aging, which we still don't fully understand yet. And I believe AI will help us get there, is something that goes on. And you don't see your right hand aging more than your left hand or your heart aging faster significantly than your lungs. Right. So what are some of the more unusual attempts being tried in these 600 groups? Oh, my God. So there's a large group is doing what's called epigenetic reprogramming. So you have 3.2 billion letters from your mom and your dad when you're born.

55:44That's your operating software. You have it when you're 20, 40, 60, 80, 100. your gene doesn't change your genes don't change and so what does change is what genes are on what genes are off and that's called your epigenome epi from the greek word for above and so the goal is can we reverse your epigenome can we take you back to a more youthful state where the right genes were on and the right genes were off and so there's a lot there's actually three or four multi-billion dollar companies funded by multi-billionaires in that space. There's cellular medicine companies that are focused on using stem cells and natural killer cell supplementation.

56:34There are companies that are focused on gene therapies to upregulate certain genes in your body. There's, you know, again, hundreds of different approaches. And we're going to learn a lot. This is a massive open source experiment and super pumped about the results. Yeah. Like, you know, that company you mentioned earlier, was it Munisys? Munis, yes. Munis. Why haven't they already won in that, you know, these 18 people are on average 30 years younger in their immune, immune age? Um, so they are a team competing for sure. And at the end of the day, uh, they've got to prove their work at a sufficiently high level, uh, that the judges are going to.

57:29So what we do is we create a, uh, a level playing ground that all of the teams compare of the sounds against each other. So that's one of the most important things that we've got going on. Well, that's very exciting. And I've always been excited by the concepts behind your XPRIZE stuff. It's very exciting and it's moving the future forward. And like you're 63, I just turned 57. I always wonder, all of these new technologies, do you think they'll, when they come out into market? Do you think they'll benefit 20 year olds or do you think they will benefit people who are like 60, 70 and, and kind of stop the clock for a little bit?

58:15I, my, my goal is, and so for example, in this wildfire prize, um, the cohort, uh, is people, uh, 60 to 60 to 85, right? So it's focused on older individuals reverting them to a more youthful state? We'll see. I think people who are in their 20s, 30s, 40s right now have a super high probability of a significantly extended health span, living to 120, living past there. I don't want to give a guess. my goal is to make it to longevity escape velocity and then be able to decide, you know, how long I want to go. I mean, this is the most exciting time ever to be alive. You know, one of the things that really helps you with longevity, uh, a friend, Dan Sullivan says, is having a future that's bigger than your past.

59:18Right. That's an interesting way to look at it. yeah and so so i'm just curious like how do you spend your day like obviously this has been your focus for a long time and obviously the x-prize predated this so you've always been involved in these moonshot like activities it did you and i've never really asked you this before but did you make money having a company that was like a moonshot company and it sold or like how did How did you make money? How do you make a living? So, well, I mean, listen, a lot of my early moonshots were in the nonprofit world, which were great, fulfilling, super successful, didn't make me a bunch of money, right?

1:00:03So while I was at MIT, I started the world's largest college space organization, right? And then I started a university called the International Space University, which is still doing extremely well. and then I started a company called Zero G for taking weightless parabolic flights, took Stephen Hawking up and a company called Space Adventures that took eight individuals up to the space station. But at the end of the day, those companies, while profitable, were not grand slam home runs. My, you know, much of my wealth and ability to invest has really been the last 15 years. A lot of my time up until then was academic and just taking a lot of moonshots in the space world, which up until Elon, weren't that many success stories.

1:01:02It was extraordinarily expensive and in the industrial military complex, Elon brought, you know, he was successful in SpaceX because he came there with$100 million in his pocket to spend to get Falcon 1 up and going, went into debt to get Falcon 1 to fly successfully, and then won a billion dollars. It's expensive. I like to say the best way to start, become a millionaire in space, is start as a billionaire.

1:01:32But for me, the longevity space and AI, I have two large venture funds, Bold Capital, which is mostly in the longevity biotech space. It's about$600 million. And a company called Exponential Ventures, which is in the AI space out of MIT. It's a venture studio and venture fund, about$500 million. And I see a lot of deals. I invest in a lot of entrepreneurs. and that's really been the last 15 years of my time is supporting entrepreneurs to go big, bold, great wealth, make the world a better place. And is there any way to kind of piggyback on, like let's say take this bold capital with the longevity investments.

1:02:20It sounds like some of these are great companies and you only need like, as any venture capitalists know, you only need like one or two successes to have an enormous success. Like if you had 100 investments, and 99 of them failed and one of them was Uber, you would be a billionaire. So is there any way to piggyback what you're doing? I mean, honestly, I back companies where I love the science and I love the CEO and I want to help them be successful. That's fundamental to the game. I do think that the majority of the success stories we're going to see in the longevity space are going to come out of AI, where AI and biotech are butting up against each other.

1:03:08We're seeing a lot of deals there. But if I could, as we wrap, if I could, I just want to tell people, my mission for Longevity Guidebook is to get it out to the world as far and wide as possible. You can buy it on Amazon, of course, and I'm donating all the profits to the XPRIZE. You can buy it at cost. If you go to longevityguidebook.com, it's available at cost with a bunch of bonuses. My goal is get it out there and give people access to the knowledge so that they feel empowered more than ever before. well peter it was a great book like i said i feel like it's kind of the ultimate summary and guidebook based on so many anti-aging books over the past 10 years many of the authors i've spoken to on this podcast so i can attest personally thank you buddy it is a summary of of the best advice from all these really brilliant people and and you've known them personally and you've gotten to ask all your questions and so on.

1:04:15And it was great to read that kind of summary plus your additional research and insights. And so I really appreciate it. And once again, I appreciate you coming on the podcast. I always look forward to the next book. They're so optimistic. People who got it, check out Longevity Guidebook, but also go back to the beginning, read Abundance, read Bold, read all of these books. Thank you. Thank you, my friend. Yeah, in Longevity Guidebook, I open up the kimono. This is what I'm doing and why. this is what has worked for me this is what hasn't worked and i'll tell you one of the things is mindset and routines like getting i'll tell you right now i feel massively disrupted on my normal routines because i'm out of my house out of my normal routine post the uh the palisades fire and you know it's like i can't wait to get back into my normalcy right because that's that's what fuels me is my red light, my meditation in the morning, my exercise, my, what I eat or don't eat.

1:05:15And, and it's, it's, there's a great power that you have, uh, in supporting your own health and, and having a mindset, uh, that believes in this and makes it worth it. You know, I think this is the most exciting time ever to be alive. And I want to see as much of it as I can. Well, I hope you succeed. So thank you, James. Thanks, Peter. Be well, my friend.

1:06:01Thank you.