How AI Learns to Smell with Alex Wiltschko - #771

8 Jul 2026 · 1 h · 24 chapters

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In short

How Osmo is building “olfactory intelligence” so AI can read, model, predict, and design smells—by creating the missing “map” for scent and the datasets/infrastructure to turn chemistry into digital representations.

Guest backgrounds

Alex Wiltschko is founder/CEO of Osmo and a former Google DeepMind researcher. He previously worked on scent-related AI at Google Brain.

Key claims

Smell is hard because it hasn’t had a scalable digitization method like images/sound; the nose encodes chemistry via 300+ olfactory receptor types. Osmo’s core breakthrough is a learned ~300-dimensional “principal odor map” derived from graph neural networks trained on structure-to-odor data. The model can pass an “odor Turing test” where its predictions beat average human panelists. Osmo also uses the embedding to generate new fragrance molecules and to support multimodal inputs (e.g., sensor readings) and mixture reasoning.

Notable examples

“Sweet/cucumber/vanilla/floral/fermented-alcoholic” clusters in the embedding (including a “bottle-shaped” fermented region); odor tracking experiments; predicting smells for never-before-seen molecules; generating replacements for regulated fragrance ingredients; Osmo has digitized ~5.43 million sniffs and claims ~6 billion molecules digitized.

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

Tap a time to open that second in VO

Understanding Olfactory Intelligence

1:01 to 2:18

Explore the concept of olfactory intelligence and its importance in AI.

“99 % of species on this planet can only speak with chemistry.”

Mapping Scent: The Challenge

2:18 to 4:36

Delve into the challenges of mapping and digitizing scent for AI systems.

“So like turn atoms into bits and information.”

The Human Olfactory System

4:36 to 8:54

Discover how the human olfactory system works and its sensitivity to smells.

“So when you say channel count in the nose, is that mapping to physical structures?”

The Structure-Odor Relation Problem

8:54 to 12:56

Learn about the groundbreaking work on predicting odors from molecular structures.

“I mean, that's how natural gas has a smell.”

Graph Neural Networks in Smell Prediction

12:56 to 14:00

Understand how graph neural networks are used to predict the smell of molecules.

“Before we get to that structure, you mentioned a graph neural net was the fundamental architecture here.”

Understanding Graph Neural Networks in Scent Modeling

14:00 to 14:20

Learn how graph neural networks process molecular data to predict smells.

“And the graph neural network is able to basically process that and propagate information and basically gather the macro structures in that molecule.”

Visualizing Odor Maps with PCA

14:20 to 16:20

Explore how PCA is used to visualize the relationships between different smells.

“And that's what the principal odor map is.”

Linking Scents to Biological Processes

16:20 to 17:20

Discuss the connection between molecular structures and their natural origins in scent.

“So there's a story of how the molecules produced.”

Creating New Fragrance Molecules

17:20 to 19:16

Discover how new fragrance molecules are developed using AI and safety standards.

“And it turns out that's a very interesting business to be in because if you can make some molecules smell great, but they're not safe or they're being removed because of new regulatory action.”

Data Collection and Olfactory Intelligence

19:16 to 22:20

Learn about the process of collecting olfactory data for AI training.

“You didn't have to collect anything and like, I don't know, like put it through like PCR or something.”
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Safety and Regulatory Standards in Fragrance Production

22:20 to 24:18

Understand the rigorous safety tests for fragrance molecules before market release.

“And that data set ultimately looks like a molecule, however you want to represent that, and a set of labels that the human might label that smell.”

Olfactory Intelligence in Scent Design

24:18 to 28:00

Explore how AI collaborates with humans to create new scents based on consumer preferences.

“It's like, are you validating that, you know, the scent is what the client wants and then you license it to them and they find someone to manufacture it?”

The Interplay of Data and Fragrance Design

28:00 to 29:04

Learn how data collection and analysis shape fragrance design and business success.

“So we're always sniffing those, those scents.”

Multimodal Embedding and AI in Scent Mapping

29:04 to 31:02

Discover how AI utilizes multimodal embeddings for mapping and decoding scents.

“There's like a few things buried in there, right?”

The Role of Data in Model Training

31:02 to 33:01

Understand the importance of data size and quality in training predictive models.

“Come work at Osmo and push back the frontiers.”

Olfactory Intelligence and Predictive Models

33:01 to 34:28

Learn about the concept of olfactory intelligence and its application in predictive models.

“In the right applications, I mean, we're really not dogmatic about the modeling approach that we take.”

Exploring the Complexities of Smell and Taste

34:28 to 36:52

Explore the relationship between smell and taste and the cultural influences on scent preferences.

“models that you know are somehow faithful to the way we understand at least the physical world or the physical process or like classical control in the case of AV versus end-to-end I don't care about any of that stuff.”

Building a Foundation for Smell Recognition

36:52 to 40:05

Understand the future goals of building AI systems that can recognize and map smells.

“So, you know, an example is like you could either choose Parmesan cheese or kimchi or strawberry.”

The Challenge of Collecting Olfactory Data

40:05 to 44:24

Discuss the challenges involved in creating a comprehensive olfactory dataset for AI.

“So we've talked a lot about kind of where this is all going and what's possible, but any additional thoughts on that?”

Expanding the Definition of Intelligence

44:24 to 47:48

Explore the idea of incorporating diverse forms of intelligence into AI models.

“You know, like one other way I like to think about this work is like foundation models for text and for images, they are approaching in some cases exceeding human intelligence.”

Potential Applications of Olfactory Technology

47:48 to 49:56

Discuss the innovative applications of olfactory technology in daily life.

“And I've very much taken on this view that like, we should have a Copernican view of intelligence.”

Challenges and Future of Nose-on-a-Chip Technology

49:56 to 52:54

Understand the technological hurdles in miniaturizing olfactory sensors.

“Like that's one of the harder questions that I, I try to wrestle with.”

Emotions and Scent: Unlocking New Connections

52:54 to 56:00

Learn how scents can influence emotions and the potential for future research.

“Ours is about the size of two shoe boxes.”

Exploring the Impact of Scent on Mood and Perception

56:00 to 58:42

Learn how different scents can influence our emotions, focus, and perceptions.

“And, um, we will get there and I think we will do it right.”
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Transcript

Automatic transcript. May contain errors.

0:00Sam Charrington:AI has advanced primarily by learning from the digital world, text, images, audio, and increasingly video. But many of the problems people want AI to solve live outside these modalities, in the physical world. Smell is one of the most interesting examples. It's how animals detect disease, identify food, navigate environments, and communicate through chemistry. Yet, scent has remained largely outside the reach of computing because, unlike language or images, there has never been a practical way to digitize it at scale. Alex Wilczko, founder and CEO of Osmo and a formal Google DeepMind researcher, is working to change this.

0:38Sam Charrington:His team is building what they call olfactory intelligence, AI systems that can model, predict, and design scents while creating the datasets and infrastructure needed to bring smell to the digital world. In this conversation, we explore what it takes to give computers a sense of smell, why scent is such a difficult AI problem, and what it teaches us about the next generation of foundation models. Here's Alex. 99 % of species on this planet can only speak with chemistry. Thinking of bacteria and fungi and plants and insects, they just only can talk with molecules. And I think that it's really worth adding other kind of alien forms of intelligence to our AI models.

1:20And the way to do that is to train it on the intellectual output of those other intellects, which is, that's chemistry. That's the sense that's in the air. They're produced by living things for reasons to talk to each other.

1:30Sam Charrington:I'm Sam Charrington, and this is the Twimble AI Podcast. For over a decade, I've been exploring the ideas and innovations shaping the future of AI through conversations like this one that help you understand what's real, what's next, and what matters. Let's jump in.

1:52Sam Charrington:When I think about giving computers a sense of smell, there's kind of two angles to this. One is, you know, there's some scent out in the world and I want my computer to be able to recognize it the same way I do. And the other, which is I think more along the lines of what you're working on at Osmo, at least initially, is to have the computer kind of grok the idea of scent so that it can create new ones. Any scent that's been given to computers, there's three kind of broad steps. You got to read the world. So like turn atoms into bits and information. You have to map it, like understand it. So, you know, be able to manipulate it, digitally encode it, send it.

2:32And that's like JPEG and RGB, right? And then you have to be able to write it back out again, right? So a printer or a display or a speaker. And so the thing we focused on at Google Brain was the missing piece, which is for scent is the map. So color has had a map for -

2:48Sam Charrington:So kind of representation of, well, what to what though? Exactly, exactly. So like, let's approach it from the side. Like, how did this work for vision? How did this work for hearing, right? We've had maps for a long time, right? So the map for sound is just one dimension. It's low to high frequency, really simple to say. And then for color, it's three numbers. It's RGB, right? Or whatever your preferred color space is. But those three numbers like tell you how to deal with color. There's three channels of color information in our eye. Of course, you're simplifying a lot because for each of those other modalities, there's lots of different maps.

3:23Sam Charrington:Totally. Those are just examples of simplified examples. And they can kind of be translated into each other. But I'm like, I'm papering over like centuries of psychophysics here. And anybody who knows anything about those things is going to come screaming at me. But you'll have to forgive the simplifications. I'm going to simplify sense stuff too. And if people talked the way that I'm going to talk, I would come after them too. um so yeah there's cmyk there's lab there's hsv there's many different maps and then there's more complex i was scarred by a dsp class in grad school okay so you came back exactly you know there's filter sets there's gabor filter sets there's you know all kinds there's huff trans like there's all kinds of ways of representing images and i'm super simplifying it right but like maps they for certainly they're there and and we know them we've known them for a while in the notion that like we can map color has been instrumental in building like CCDs and CMOS and therefore like digital imaging.

4:16Exactly. And then also the printers, right? So like the ink in the inkjet cartridges, we know we can combine them to make millions of colors. There's three channels of color information, roughly, roughly RGB in the eye, but there's over 300 channels of olfactory information in the nose. And it's still a mystery exactly what they code for, but it's certainly much higher dimensional, at least in terms of channel count.

4:40Sam Charrington:So when you say channel count in the nose, is that mapping to physical structures? I'm going to butcher this, but for the eye, I'm like, is it like rods and cones and stuff like that? Exactly. Yeah. So there's rods and cones and together there's like four channels. They're like roughly RGB grayscale. Again, there's a lot of details there. those are specific receptors that are encoded in your genes, right? Expressed in cells in your eye that are sensitive to light. So the equivalent for smell are those cells are called olfactory sensory neurons. And those cells actually start in the brain and they poke through your skull and they actually touch the world.

5:21It's one of the two parts of your brain that actually leaves the skull. And so when you smell something, your brain is physically touching another living thing that's like let off a little bit of some of itself for you to smell. So there are millions and millions of olfactory sensory neurons in the part of your nose, the inside, that actually does the smelling, that's sensitive to smell, called the olfactory epithelium.

5:44Sam Charrington:Does the nomenclature here that these are sensory neurons imply that they're more fundamental than a rod or a cone, which I'm imagining are more like superstructures, like bigger things. I'm probably going to mess this up, but rods and cones are cell types. And so those are names for types of cells. And there's many other types of cells in the retina that'll help kind of compute the raw information that these cells get. So the equivalent of those like primary sensory cells, like without these cells, light doesn't turn into awareness, right? So it's the front line, right? So the front line cells for smell are called OSNs or olfactory sensory neurons.

6:22And these cells at the tip, they basically shove part of their cell membranes into a little mucus membrane that then touches the world. And those little tips are just chock full of proteins called olfactory receptors. And those are the things that actually sense the chemical world. And so how many of those olfactory receptor types are there? Over 300. So that's where that number comes from is each of those receptor types are differently sensitive to the chemical world, right? Just like some rhodopsins, those are the proteins that actually sense light. Some are sensitive more bluey and some are sensitive more greeny.

6:58Some are more reddy. And there's hundreds times, there's a hundred more different types in olfaction.

7:08Sam Charrington:So what does that say about the resolution of the human olfactory system? Like, is there like a number of smells that the typical person can smell like? I don't think we have a good estimate for that. There is a very famous paper, which has a trillion, which has been pretty thoroughly debunked. But I don't know if we can really estimate that. There's a few things, though, when you talk about sensitivity, right? So I had laser eye surgery, so I had glasses for most of my life. I couldn't really see that well. So I couldn't resolve really subtle differences, but I wasn't blind. I could perceive all the light.

7:53So light was getting in, but I just wasn't being focused properly. So with smell, as long as your airways are working, you can smell and detect things. You might not detect subtle differences, but you definitely are sensitive to it. And some people aren't and they have their, you know, airways closed for various reasons, like anatomical or an injury or something like that. But like, you know, there's an amazing experiment by Noam Sobel who showed that actually people can do scent tracking. So if you put on a blindfold and you get somebody down on the ground and you leave a little trail of like chocolate or cinnamon or whatever, people, if they concentrate, can actually centric just like a dog.

8:34They're super slow, but they can do it. So that just goes to show that there's this, I think, a myth that we're not good at smelling. We're freaking amazing at smelling. We can smell the equivalent for some molecules of one little teardrop in an Olympic-sized swimming pool. We are so sensitive to some things. I mean, that's how natural gas has a smell. It's just the tiniest amount of these molecules called mercaptans are added to it and we can smell it like super sensitively, like parts per billion or trillion. It's crazy. So, I mean, we're good. Like humans are good at smelling. So we're trying to build this map.

9:12Sam Charrington:We have this structure that we know about from biology. Do we know like, how do we, you know, what's next, I guess, like how do we represent that structure or what's the next step from? I'll walk you through how we thought about doing this or how you have done it. Step number one for us was there's a really basic version of this problem, which is like, I assume you're only smelling one molecule and you know its structure. Like you can draw it on the board, like you're in high school chemistry class with like atoms and bonds and all that. And you know what it smells like. So this particular sets of, you know, combinations of carbon and nitrogen and oxygen smells like sweet, smells like vanilla, smells like phenolic, smells like chocolate.

9:55Like those are maybe four descriptors drawn from a set of 100 that apply to that molecule. Well, okay, go get thousands of those pairs and then train a neural network to predict that relationship from structure to odor. That problem called the structure-odor relation problem had been unsolved for 100 years. And actually, in some cases, people thought it was unsolvable. And so what we did as one of our first kind of outputs at Google Brain was we just trained a relatively new, at the time, kind of neural network called a graph neural network, which was specialized for chemistry. It's actually very related to the transformer.

10:35It's kind of been subsumed by the transformer in the intervening years. And we were able to predict what things smell like very well. In fact, so well that we said, why don't we set up an odor Turing test? Let's go find molecules that nobody's ever smelled before. Some have never been made before, like nature has not seen them. Let's predict what they smell like ahead of time and keep our prediction secret. Let's go get those molecules physically, send them to another location. I have a great collaborator that I worked with on this. His name is Joel Mainland at Monell. Let's train people to smell and describe smell.

11:08It doesn't take a ton of training, maybe like eight hours to do okay at like, hey, this smells grassy or phenolic or vanilla or cucumber, you know, and maybe 50 terms you can be trained on. let's double blind, have these people smell and describe completely new molecules, and then compare how well this panel of people does to, first of all, some individual panelist, because one person is always worse than the average of the panel. So let's compare that to our model. So the question is basically, you know, the odor turing test is, if you want to make your panel better, would you rather add another person or would you rather add the predictions of a model, right?

11:48And it turned out our model predictions were better than any one individual panelist on average in the panel, meaning that we've passed a Notre-Durion test. Like our model predictions were human quality, which was pretty cool. That was the first thing. And what we did with the neural network is we cracked it open and we looked at what's called the embedding layer, which is a part of the neural network that basically turns the inputs into a vector. that's that is the map right and then that map is what we kind of can slice up in regions and use for classification so this region of the map is vanilla this region of the map is red berry etc um without that you actually can't do that classification problem so that embedding turned out if you do the engineering right it just kind of needs to be around 300 dimensions to work really well which is like suspicious but you know just suggestive right i can't make any claims um but that embedding had a ton of beautiful structure in it.

12:45And that seemed to be a first candidate for a continuous predictive map of smell. And we called it the principal odor map. And that's been foundational to what we've built at the company since then.

12:56Sam Charrington:Before we get to that structure, you mentioned a graph neural net was the fundamental architecture here. And what are the nodes and the edges in the graph represent? Yeah, great question. So like if you were doing machine learning on a social network graph, the nodes would be people and the edges would be relationships between people like friendships. And then it might be one very large graph of Facebook or Twitter. In our case, every graph is a molecule and the nodes of the molecule are the atoms. So it might be a carbon, it might be a nitrogen, it might be a sulfur or an oxygen. And the edges in the graph are the bonds.

13:37And that might be a single bond, a double bond, a triple bond. And the graphs aren't very big because molecules that have a smell aren't very big. If they were huge, they actually wouldn't make it into the air and fly away. And if they were also huge, they wouldn't fit inside the binding pockets of the olfactory receptors that we talked about. So they're not too small. They're not too big. They tend to be less than 20 atoms, but more than like three or four. And so those are the graphs. Those are the inputs. And the graph neural network is able to basically process that and propagate information and basically gather the macro structures in that molecule.

14:12And then eventually you turn that into a fixed length vector that like describes how that molecule actually might smell. And that's what the principal odor map is.

14:22Sam Charrington:And so now the structure that you observed in the embedding space, talk a little bit about that. Sure. So we took that, you know, almost 300 dimensional vector and we took a two dimensional shadow of it so we could look at it. And we use something called principal components analysis to do that or PCA. And what we did is when we plotted this two dimensional map, we made every dot on that plot be a molecule. And so there were about 5000 dots on that plot. What we did on that plot is we circled regions of molecules that all had the same smell. So the sweet neighborhood, the cucumber neighborhood, that kind of thing.

14:56And they didn't have to be neighborhoods, right? Like all the cucumber molecules could be completely spread out, in which case every region might actually be all overlapping with each other. But what was really beautiful is if we circled the floral region, it was this pretty big part on the left. We can share the images with the listeners if you'd like, but the floral region was pretty big and was on a side of the left. but then if you draw like jasmine or rose or um you know violet they actually ended up being sub-regions inside of floral and we didn't tell it that like we didn't tell it that there was this nested relationship of nature there and similarly the the region for um for fermented and alcoholic was actually shaped like a bottle during our first model train we haven't touched it since because it's so funny um but things like fermented and whiny and like rum uh those those all fermented alcoholic um since we're all in the same region as well and And this pattern continued for basically all of scent.

15:51I mean, I thought that was very beautiful. One thing that really struck me with that map, which we're still working out, frankly, is these scents. Actually, if you blur your eyes, it almost looks like how it's a story of how nature makes those scents. Right. So fermented scents, like from wine or rum, et cetera, those are made by yeast that are from actually it's a biological process. that's producing these molecules, right? So there's a story of how the molecules produced. And same with flowers. Those are all genetically much more related to each other than they are to, say, other species that produce nuts or, you know, bark or whatever.

16:32And they're all clustered together. So in a way, like, there's this story of, like, actual biological life and scent that seems to be very tightly woven together.

16:40Sam Charrington:And are there, like, confounding examples there? I'm imagining, you know, both fermentation and florals are kind of these natural scents, but are there other scents that are like completely unnatural? Maybe the thing that we put in natural gas to give it a smell like, and what are the shapes of these non-organic smells like differ in some fundamental way? Actually, that was our first line of business that we started was like, can we somehow make new molecules that smell great and that are safe and that we can produce at scale and that are affordable, all that. And it turns out that's a very interesting business to be in because if you can make some molecules smell great, but they're not safe or they're being removed because of new regulatory action.

17:34So we need replacements because we want our products to smell great, like our laundry to smell great, our home to smell great. And so we actually use these models, which we've developed, you know, over the many, over many years to actually find new fragrance molecules that have never existed in nature before. And then we make them and we could bring them to market, which we're in the process of doing right now.

17:55Sam Charrington:And so when you're doing that, is your objective, like, I'm imagining that somewhere in some prior step, you've got a classifier of like smells great, doesn't smell great. and you're trying to map to that as opposed to, you know, or you could be, well, I want it to be like floral or I want it to be fermented or I want it to be lemony or something like that. How do you guide the process? It's always really specific, right? So in our industry, it's pretty clear what the molecules are that need to be made. So, hey, we're missing a citrus molecule that is long lasting, or we're missing a vanilla note that is optically clear because vanilla is typically brown.

18:42And so you don't want, you know, people want clear fragrances so that they can change the color of the product. And there's many others like this, but, you know, we kind of know what we need to make. And so we typically focus the team because it's ultimately team that's doing all this with, you know, physical infrastructure of all these models and a lot more chemoinformatics on the kind of highest priority items. And of course, we discover some interesting things by accident along the way. And we don't ignore those. The initial set of molecules were these, these are just kind of known, like written down.

19:19Sam Charrington:You didn't have to collect anything and like, I don't know, like put it through like PCR or something. Like we just, we knew what these are. Yeah, we didn't have any labs at that point in time. And so the data that we collected partly through, we did some creative data licensing. We also found some stuff on the internet. I mean, I had been in the world of Scent for like 15 years when we started that project. So I was like, okay, I know where I'm going to go to get this stuff. And we were successful. And since then, we've dramatically scaled up our data collection abilities. So, you know, we had, I think, 5 ,000 molecules in our first data set.

19:55we've digitized six billion molecules at this point um what does that mean walk us through that process so we've enumerated all the molecules that could possibly be made so as in the real actually realizable physical molecules um that could possibly have a smell um and uh we basically ran predictive models on all of them and we've made a huge number of them um and so we've made

20:22Sam Charrington:more new to so this is that the initial part of that statement is like there's some physics that governs you know what the ways that molecules can form and you can like filter that based on some set of criteria the three atoms the 20 atoms and maybe like these bonds work these bonds don't work and then you you get some like starting place this list of potential and there's a manufacturability filter as well. So you ultimately end up with this list that you... Big list. A big list that you kind of derive like from first principles, like the way that these things work together. Is that the idea?

21:04Yeah, that's right. Exactly. So those are like, those are real molecules. We can make any of them and they're more likely than not to be able to have a smell. And then the rest of like, whether they're useful or interesting or beautiful, we have ai models to predict all that stuff um as well as safety safety is really critical um and uh that's kind of one of our core data sets the other thing is we've smelled a lot like so we train people to smell there's many different protocols for how to like smell something hey does this smell good or bad or intense or not intense is this better than the other one there's like many different ways of doing this and we've gotten really good at dialing that in and we have people basically internationally that smell and so we've uh i think i want to get the number right it's probably shifted since i last looked this up like a week ago but we've digitized 5.43 million sniffs um so that's like the largest olfactory data set for you know the purposes of training ai models i think ever um and uh that's we had to make all of that from scratch right like there's no scale ai or there's no mechanical turk for smell like we've had to make that internally, consume it ourselves and generate huge amounts of olfactory data for olfactory intelligence.

22:20Sam Charrington:And that data set ultimately looks like a molecule, however you want to represent that, and a set of labels that the human might label that smell. It can be broader than that, right? So that's a part of our data set is like we know the molecular structure and then we smell it and label what it smells like. But it also might be like a cucumber you buy from in the grocery store that we smell, right? Or we might, and that's the case of analytical annotations, it might be a product, like a market product. Okay, so a thing and a smell. A thing and a smell. Not necessarily a mug. Exactly, and sometimes we don't just smell it, we put it through analytical machinery, right?

22:55So that gets to how you actually, where does the real world data come from? Like you need to use chemical sensors. And so we've put huge amounts of data through chemical sensors. And then we also can align that with human sensory labels so that we can begin to actually relate sensors to human perception, which, and like, that's kind of core to what we do.

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23:13Sam Charrington:And when you're in this part of the process where you're manufacturing these molecules, like, is there, are there known toxicity screens that you can? Oh, yeah. You have to go through a very rigorous process in Europe and the U.S. and worldwide. And there's a binder of tests you have to submit. And they're really thorough and they're the right test, right? So, you know, is this safe on your skin? Is it safe to breathe in? Is it safe for your eyes? Is it safe for fish? Because you might flush some of it down the toilet or in the shower drain right after you wash yourself with a shampoo. The question that I'm curious about is, can you derive that from molecular structure or do you have to do it empirically?

23:55You can predict it, which is super important for how we're so efficient in what we do. But then you have to test it physically. It's just the law. And it's the right thing to do. Like you just check, right? Do the experiment. And we do over and over for all the products that we're taking through regulatory review.

24:13Sam Charrington:This is maybe a digression from the kind of technical conversation I want to have is like the business side of this thing. It's like, are you validating that, you know, the scent is what the client wants and then you license it to them and they find someone to manufacture it? Are you like making the sense at scale or like? Where we do most of our business is we actually blend molecules and ingredients that already exist and are already approved. And so like if somebody comes to us and they want to launch an air freshener or a shampoo or a fine fragrance, we need to, in order to get that out quickly, we need to be able to blend molecules together that we can get.

24:50And we actually stock many of these ingredients. And we've taught olfactory intelligence, which is really a fleet of different models, how to convert like a customer's request. Like, I want a scent that smells really fresh and clean and, you know, is going to be useful or liked by Gen Z men. Like, that's enough of a specification to kind of begin to make a scent against that. And then we have master perfumers and perfumers.

25:15Sam Charrington:Two-thirds acts. Just mix them together. I mean, you're not too far from the truth. Like, generally new scents are like existing scents, right? Because, you know, scent is art and, like, art evolves. It doesn't, like, take these crazy jumps, right? So you can always tell what the lineage of a scent is. And like, yeah, Axe is one of those, right? Axe is actually really famous because it was the first time that fine fragrance perfumes were actually brought to that mass market price point. So some of the scents in Axe body spray had never been like accessible to the average person because those...

25:50Sam Charrington:I never associated Axe with fine anything. So yeah, exactly. It's like it's built its own rep over the years. But like the way those scents were actually chosen in design were super interesting from like a marketing and kind of scent development perspective. But we've taught OI to collaborate with perfumers and also just work directly with our customers where you basically prompt it. And you're like, hey, I'd like to design a scent. Our perfumers use it as inspiration and our customers sometimes design their own scents for themselves. Right. In fact, I had a conversation earlier today where I sent somebody an OI design scent and they loved it.

26:21They picked it. They're going to launch it. Right. like just right out of like our software system. So you can think of that as like a Canva, right? Or a Figma for CENT where, you know, you and me can make CENT that wins in the market. And so that's what we've put it all together with.

26:37Sam Charrington:So the foundation of this is the, you know, this embedding space that you've framed. And I'm envisioning the task that you described as being akin a little bit to the Word2Vec embedding space math, like king minus, I always get the formulation wrong. Yeah, it's like king minus man is equal to queen minus woman or something. There's arithmetic, right, in the text space. Yeah, exactly. So, no, it's really similar, right? So the core business for us is, you know, you want to launch a brand that has some smell in it, like a shampoo or a fine fragrance. You got to get the scent made. So we actually have a factory where we make it.

27:16But the core algorithmic pipeline is we take your text or image or audio description and then we embed it into a perceptual space. And there's lots of steps involved in getting that right and having that be commercially viable and acceptable. But then we then have to decode from that space back to a formula. And that formula is a set of instructions for a formulation team in the factory behind me and a big robot that's the size of a school bus that can make a new fragrance every 100 seconds. Um, and, uh, that's basically how all this is strung together. And the algorithms are of course driven by data.

27:52And every single time we make a new scent for a customer, like, yes, they're happy. We're happy because we get paid. They're happy because their brand is working. Uh, but we also get data, right? So we're always sniffing those, those scents. We're always putting them through our chemical sensors. And so it's, it creates this really nice, like self-perpetuating machine where we found a business where we can serve the world and like actually help people be happy. and like become wealthy and grow their businesses. But also like it helps us on our mission, right? So the last thing that we do is not going to be fragrance design, but it is certainly the first.

28:27And so it's teaching us and it's also funding us. And I think that's a really powerful, like I'm glad we found it because I think it's really, really powerful for what we're trying to do.

28:36Sam Charrington:But there are a couple of things in there that I wanted to dig into. You know, essentially the encode and decode parts. It's like you mentioned multimodal and that's like super interesting. So I can describe this thing, but also say like, I want, you know, I want this scent to evoke this image, like or this image to evoke the scent, whatever the directionality is like. And so the first question is like, how did you go from like this kind of molecule map thing to this multimodal embedding space? right and then on the decode side okay you know you found the neighborhood of some you know some thing if it's if we're still like in the regime where this embedding space is fundamentally embedding like representations of molecules like how do you get from that from that like a single point to well that's a mix of these five things is that also ai or is that more deterministic or experience-based thing?

29:43Great questions. There's like a few things buried in there, right? So the first is the map that we discovered, like we've evolved the system a lot. So what I'm going to say is like the gist, but the implementation and engineering details have kind of diverged from what, like, the simplest way to describe it. But like, here goes. That map, that roughly 300-dimensional principle order map, the first model that we trained does indeed take single molecules as inputs. But there's no reason that you can't target that embedding with other inputs, right? There's no reason you can't target it with a...

30:16So like, what about a chemical sensor? Could you just like chop off the head of that neural network and like, you know, put it on another neural network that took in like chemical sensor readings? And the answer is like, yeah, you can for sure do that. So the question is not so much like, how do you crunch everything down to the original input space? It's more like, how do you map new inputs into that same space? And we've been able to do that. And then there's a question of, How do you deal with mixtures? And like that is the holy grail. And we've spent a ton of energy and time and science on how to do that.

30:48And I'm super proud of what we've done, what we're doing, what's still ahead. But like the special sauce is really there. It's like how do you reason about how these molecules interact? And that's a good question, but I'm not going to get the answer. Not a detailed answer. Yeah. Come work at Osmo and push back the frontiers. It's like it is the special sauce. ultimately like truly like the data that drives it is actually the the moat and so i think we have the largest olfactory data sets in the world ever but more importantly the rate at which we're generating data just far outstrips anybody right like even the companies have been around for 100 years like they say they have data but they have is a lot of excel spreadsheets that don't actually kind of add up to much and so everything that we do from the very beginning has been designed to be collected for analysis and for model training.

31:37And that makes all the difference. Yeah.

31:40Sam Charrington:So data and model training suggest that that mapping is indeed a learned thing. It's another model as opposed to, you know, the relationship's not that complex or it's business rules or definitely not business rules. I mean, like, you know, as with any like AIML project, you always start with the dumbest models first and see how far it gets you um and then uh in the most interesting cases like you're like that's actually not millennial equals x exactly exactly yeah just you know keep keep pushing the same sense like still polo blue it's still abercrombie and fitch fierce um and like that's not that's not that wrong right it's just you'd like to be a little bit more nuanced with it um and those are great sensitives to the test of time truly um but uh uh it's yeah it's really an exercise in collecting very very large data sets tailored for ai and then what you do algorithmically on top of that like when we started the company like whatever almost four years ago knowing how to build specific kinds of models on this data modality was super important and that's actually like been an accelerant for us um but really like a lot if you just have great data, a lot of stuff kind of falls out from it.

32:54But you have to be careful with every step of the way and have great, great people who are thinking about every step too.

33:00Sam Charrington:And does graph models still figure significantly into what you're doing or have you evolved to transformers? In the right applications, I mean, we're really not dogmatic about the modeling approach that we take. We're really dogmatic about data size and data quality. Does the implication then that you spin up new models for individual projects as opposed to what I envisioned was that like you had like the olfactory foundation model and that thing changes infrequently and you just use it for a new task? So when we say olfactory intelligence, we kind of mean like the suite or the fleet of predictive models on all aspects of smell.

33:39And there's dozens. There's dozens of models. And if you go look at like Neolabs or life sciences companies, some of them are pretty upfront that like their core model or foundation model is actually a fleet of models. And that's how self-driving cars work too. Self-driving cars are driven by like a fleet of models that all connect together along a spine to coordinate sensing with action, with planning and all that stuff. So I think the way we think about it is closer to autonomous vehicles, which is actually where my CTO's kind of background is. So Rich ran the data architecture for NVIDIA's autonomous vehicles program.

34:13We met at Twitter when we were working there, and then he went to Spotify and did Brexys.

34:17Sam Charrington:but you know that in and of itself is interesting and opens up this question which is like in AV there's this tension that I've explored quite a bit through interviews between models that you know are somehow faithful to the way we understand at least the physical world or the physical process or like classical control in the case of AV versus end-to-end I don't care about any of that stuff. I'm not going to like human tinker subsystems, whatever. I'm just going to end and train on data. It sounds like you're more in the, like we've got this physical understanding of, you know, olfactory systems or some process for developing these scents.

34:59And we're going to like have sub components

35:02Sam Charrington:or sub models. Yeah, I would say one part of that's true and one's not. So the one that is not true is like, we don't necessarily strive for physical understanding. We strive for predictive accuracy and like helping our customers and like, you know, building like being able to predict the right thing to like keep the organization going. And it doesn't sometimes we use physics like that's just a modeling choice is like using a physics based model. And I would say we actually cannot do one fully unified model because like there's regulatory work that has to be done. And so like you kind of need one prediction for is this safe in this specific way.

35:41So you got to have like at least, you know, it could be one model with like 12 heads, but you do have to have those specific outputs. And there are specific data sets that need to be used to like train those. And they effectively become independent, you know, models in that regime.

35:55Sam Charrington:Yeah. Got it. So the, the sub models are like, is it fair to say the core is predicting a smell, but then, you know, you've got these other heads or attributes that you're also trying to predict, which are toxicity, maybe manufacturability, maybe cost to manufacture, maybe whatever. Regulatory safety, you know, all that stuff. And like, you can't really skip any steps, right? They're all required. But yeah, the core is like, what does it smell like? And does it smell good? And does it smell strong enough? Like those are kind of the core things that you need. And then everything else you can figure out.

36:36Sam Charrington:Does it smell good? Is that a derived property of what does it smell like? Or do you also predict that independent of what it smells like? It's a derived property of the scent tupled with the target consumer. So, you know, an example is like you could either choose Parmesan cheese or kimchi or strawberry. Like, depending on who you show it to, they may or may not like it. And in the case of strawberry, actually, the kind of strawberries that people think of or want in Japan actually are pretty different from the ones that we think of or want in the U.S. and so well those are the like the gift ones but just like the the flavor right of them it's like it's a different sweetness profile it's like almost borderline different fruit in terms of how you construct it in a product um but you know like what you like is heavily heavily driven by what you've been exposed to before and like and what what did you feel like when you got exposed to it.

37:39And, you know, if you're in a Korean household, being exposed to kimchi is like, you do that under like warm family conditions. And if you're exposed to kimchi, it could be like literally whatever. If you're, you know, a non-Korean person who's never experienced before, you're like, what did I just open? I happen to love kimchi, but it was an acquired taste. And similarly, like from my culture, there's all kinds of like, you know, horseradish and filter fish and noodle kugel and all this stuff. So like, I love those things, but that's like my people's food. Like that's what we eat and not everybody likes it, but I'm into it.

38:13Sam Charrington:Which raises a question about, um, taste, like, which is kind of, I guess, you know, it's more adjacent to smell than it is to physically. It's pretty close. Yeah. And so does that, um, you know, is that something that you dabble in? Is it far enough a way that you don't you know think about it we think about it a lot we don't work in taste today because we're really really focused on our kind of first vertical and like we gotta we gotta focus um so there's kind of three aspects to this so there's smell which is for sure just like what comes in your nose but also like you can smell things that go the other way it's called retronasal olfaction um so when you're eating something you're actually creating this chimney effect that like kind of has scent basically vent the the reverse way um and so you this is how flavor is produced right so if you ever eat a jelly bean and hold your nose you actually can't it just tastes sweet you can't tell if it's like lemon or lime or grapefruit or whatever um so flavor is 90 smell 10 taste and taste is just what happens on your tongue like sweet savory sour salty umami all that um and bitter uh but it's in terms of dimensionality and richness again like i'm sure the taste neuroscientists would kill me for saying this but like it's just not as complex like there's just there's less diverse they've only got six we've got sorry you can have a taste person on your podcast next and they can defend themselves but like they just there's fewer channels of information and it's and for sure the experience of flavor is like destroyed if you cannot smell.

39:48Just ask people who lost their sense of smell in COVID or who've ever tried the experiment of just like holding your nose when you, you know, eat a bite of anything. So all that to say that like flavor is super related to fragrance and it's kind of there waiting for us when we're ready, as it were. So we've talked a lot about kind of where this is all going and

40:10Sam Charrington:what's possible, but any additional thoughts on that? Like I want to give computers a sense of smell and that means reading and mapping and writing smell and you know we've been on our journey super pragmatic about like building the scientific capabilities which is the first two years of the company and then finding a great business to go put this to use in which is the fragrance industry but like we like we're going to go further than that um and in fact we're talking with a number of organizations like i think the thing that's needed now for not just design of scent but the detection of scent is exactly what you're talking about from before which is we have to build a foundation model.

40:47And the thing that's been missing and that we've been building is you have to collect a whole bunch of data, right? And like, you know, for instance, if you wanted to do the very, very noble work of smelling someone with cancer early, detecting their disease early, or if you wanted to detect early infection with malaria or another infectious disease that claims the lives of mostly kids.

41:16Sam Charrington:That's super interesting thinking about those as data collection problems. But so here's the deal. You can go directly after that and like collect scent data from people with or without those conditions and try to build models. You're never going to get enough people to build a great model, right? And like there's just, it's hard to go get that much data. Meaning because there's not enough signal and the correlation between scent and disease or some other factor you speak? Just low numbers. It's just from a pure statistics and machine learning problem. You know, I think basically there's not an obvious, obvious, obvious signal that says this person has, you know, a disease and then doesn't.

41:57There are subtle changes across like many, you know, hundreds or potentially thousands of molecular signals. We just don't know. But we know dogs can do it. Like animals can actually detect these patterns. So there's something.

42:08Sam Charrington:Right, that's what I was thinking of when you raised the example. It's for sure there. It's for sure there. um but we can get computers to do it we just need to go get a ton of data right like we need to like band together and build a huge effort where we just like let's go sniff 10 000 people i don't care if they're healthy or sick i don't care how old they are i don't care i mean let's record all that information of course but like let's just go get a ton of data let's go to the grocery store and get cucumbers and bananas flowers and like steaks and whatever um and let's just go smell everything and then build a huge olfactory data set of what the world smells like and if we can do that then then it sounds a lot harder than scraping reddit one more time a whole lot harder than scraping reddit but it's worth it because literally nobody's gonna do it unless we pull pull ourselves together so like but this it's like worth doing right like you know this is the thing that maybe isn't a sign but like i have a lot of friends in the world of ai and ml and you know i came in through this as a biologist and as a biologist like you go do experiments and it's like hard and like you got to go to the bench and get your own data and you know it's gritty um and in the world of ai like you kind of just assume the data is out there and if the data is not out there you kind of assume you can give somebody a credit card to create the data um and like i think that's amazing but like the amount of infrastructure that you have access to is just astoundingly huge and like you just have to understand that if you want to like continue to expand the realm of like what AI can do and compute can do, like it might get hard.

43:38Like you might reach a point where there's not a vendor that can handle everything for you and, you know, shine your shoes or whatever. Like you might have to go to the work yourself. And so we're very much in that regime. And I love it. Like it's, it's so hard. It's just, it's beyond brutally hard. But I love it because nobody else is doing it. Right. And like, that's very much my preference for how I want to spend my life is I want to do weird things that nobody else is doing that matter, right? And so that's kind of my selection criteria. Like there's plenty of people that can go build, you know, AI voice agents for customer service.

44:11I think we're going to need that to like make commerce better. Like I'm not the guy to do that. Like I want to do this weird thing, right? I want to give computers a sense of smell. And so, you know, I think where we're going is like we are collecting huge amounts of data, but importantly, like we have this platform that allows us to store all this data, organize it, like massive efficiencies of scale digitally and then increasingly physically we can make a huge number of unique sense like we have all this infrastructure that we've built painstakingly over over a few years and now like let's go let's go get all the smell data right like and let's build this chemical um like slice of reality uh into ai which likes building a true olfaction uh foundation model and but but the data comes first right like we need to go get all the data and then like you know when whenever these models come out like opus 47 or when mythos comes out or codex 55 they talk about uh the model card in terms of all these benchmarks and so what i what i imagine for the future is that we'll collect all this foundational data and malaria detection will be a benchmark all right and cancer detection will be benchmark and you know building a great um market product for a new shampoo launch in Malaysia will be a benchmark.

45:27Sam Charrington:But... Or even the idea that the generic, this is where I thought you were going, that the generic foundation model that you are using, by generic, I mean kind of general purpose, part of a better term, is not just text and, you know, multi kind of the common modalities, but is now has, there's some kind of benchmark or model card statement around, you know, smell and taste and... Yeah, it's like, let's add these weird new benchmarks, which is like, how well can we predict, you know, what something smells like or how some smell that we detect in the world, which is just a combination of molecules, is predictive of something that we care about.

46:06You know, like one other way I like to think about this work is like foundation models for text and for images, they are approaching in some cases exceeding human intelligence. Certainly mine in certain regimes where I've been pushing it, I'm like, holy crap, this is smarter than me now. it's human intelligence. And that's because it's trained on human intellectual output. But 99 % of species on this planet can only speak with chemistry, right? Thinking of bacteria and fungi and plants and insects, like they just only can talk with molecules. And I think that it's really worth adding other kind of alien forms of intelligence to our AI models.

46:50And the way to do that is to train it on the intellectual output of those other intellects, which is, that's chemistry. That's the sense that's in the air. They're produced by living things for reasons to talk to each other. and uh you know terry tau who's this famous mathematician he has this one paragraph in a paper he just wrote where you know he's he's you know reflecting on these new forms of ai and the kind of weird mathematics that they can do and he says you know i think increasingly we need to have a copernican view of intelligence meaning for a long time you know in astronomy we had the earth at the center but then we had to dislodge it to actually face facts um and earth's a great place to be, but it's not the center of the universe.

47:30Right. And similarly, we've placed human intelligence at the center of the debate about artificial intelligence and like pretty cool to be human. It's awesome. I love it. But like, why should we be the center? Like what other forms of intellect are there? And so when he, when he, when I read what he wrote, I've kind of instantly, like it instantly resonated with me. And I've very much taken on this view that like, we should have a Copernican view of intelligence. There's so many forms of it. And there's so much richness out there of things that are intelligent, some of which we might not even recognize as such.

48:03And I think if we're building AI for our species and for the planet going forward, like we should have those forms of intelligence built in.

48:13Sam Charrington:Thinking about all the progress that we've been making in broadly physical AI, robots, autonomous vehicles, all that, and thinking as well about how good our sensors are for this approximation of visual stimuli. like do you have a sense for i'm imagining you do like where are we with like the you know olfactory cmos or whatever that uh you know knows on a chip i would say the devices that we use to detect chemistry are truly phenomenal but they're they've been very specialized to live in a laboratory so think about computation in like the 1970s big mainframes right stuck in a back office or like a data center, right?

49:04So we're still in the data center era of chemical sensing and of olfactory intelligence. So like our scent printer is the size of a school bus. It's just not, we're not gonna, that's not gonna leaf. That's bolted into the concrete, right? Yeah. But eventually all the - We just need those wheels on the school bus. Not wheeling that out, I promise you. But all this should fit in our phone, right? Over time. And that's the story of technology is something that works, that's valuable. And now we just like work really hard to make it small. So that will come.

49:34Sam Charrington:The cancer example is a good one. What are other examples of, like, if we had the auxiliary olfactory apparatus chip on the phone, like, what would it let us do that our noses don't do for us? Super excited by is just, like, the creativity that I think would come if we opened that up to everybody, right? So, like, how could we have predicted all the apps on the App Store, all the uses of camera phones and all that stuff? Like, it's just incredible. um i think that there's definitely things we can contemplate everything that a dog's nose does right i'm thinking of the app that you download that tells you who actually dealt it exactly all right well the old factory fingerprint is definitely sam today um i've got data to prove it um so they'll definitely be fart apps for sure in the future i just like it's human nature like i've you i worked at twitter and we clean up like i just i know human nature it's just like you know we've got a fascination with many things including the scatological but um i i i i think that um anything that a dog's nose can do and there's like 80 things more or less that you can train a dog to do like detects so tracking for example on your phone exactly that's an amazing spoiled produce spoiled meat and these are these are things you want in your fridge right you want to know can i eat this should i eat this right is it done is it cooked that's useful for a robot kitchens um there's so many things that the human noses and dogs noses can do none of the examples alone i think are so far that we've seen are huge businesses or necessarily accessible businesses smelling cancer is important but like the business there is really rough right medical diagnostics are like not a great unfortunately not a great business to be in um and uh it's just figuring out how to actually like, like not only build it, but then make it self-sustainable.

51:28Like that's one of the harder questions that I, I try to wrestle with. And I don't have the answer, frankly.

51:33Sam Charrington:Do you feel like that, the difficulty of that question is, I mean, clearly like it's suppressing the development of the technology, but do you think that it's like, if the business model was there, we could easily figure out the nose on a chip or is it just really, really hard? And therefore the, the bar, the economic bar is really, really high. I think it's a blend. So if the business model was figured out, I think we would have been sprinting at this for the last like four years exclusively as opposed to building a really great business in the fragrance industry, which seems unrelated. But when you really get down to the, you know, the science and the technology, it's super related.

52:13But we have devices that you can bring people to or that you can wheel around that can do this, right? um it's just a matter of uh how do you throw an appropriate amount of resources behind like scaling that miniaturizing that very possible right i can easily easily envision a device that's the size of like what do we call this like i don't know like an 80s cell phone so bigger than the cell phone but like kind of a bigger box right i can imagine a box that's like you know about that big, like, I don't know, a small baby shoe shoe box that can smell as well as a human nose. In fact, we're pretty close.

52:54Ours is about the size of two shoe boxes. We have a deployable sensor that's as good as our nose as you and me. And it's the size of two shoe boxes. It works. So getting that smaller, very straightforward engineering, not easy, but like straightforward, going smaller than that and like putting it into something the size of this phone and then putting it into a chip the size of this phone that's going to require some creativity and some work and i actually i couldn't tell you exactly how that's going to happen i can tell you that we have proof it lives between our eyes and our nose right like we're walking proof but um yeah there's a lot there's work to be done to actually like make that uh affordable and pervasive yeah

53:33Sam Charrington:yeah something you said maybe think about you know is there some inherent limit in the application of MLAI or the way you've done it and that like what's important isn't really mapping to like you know single label scents like you know cucumber or cinnamon whatever but like mapping to emotion which is a much richer thing but certainly if you're like you must be already doing that that's what people are trying to get at yeah we think about that a lot yeah so I I think there's there's first of all there's more labels than just cinnamon and cucumber uh no no i don't i don't mean like we didn't name enough i mean like there's other ways of labeling like these two are really similar or they're dissimilar and here's a scale so the richness of of sensory information once you start to not use human language and use like numeric scales which you can do it just takes some some fine tuning you actually you learn a lot about the chemical world when you start to label things more carefully that way um i mean in some sense that's the original observation from the embedding work at google is that proximity actually means perceptual so things that are nearby on the map smell similar right yeah exactly um and so then that like I don't know how you would do this, but I'm envisioning like jointly embedding emotional somethings, uh, emotional valences with, uh, you know, olfactory information.

55:09Sam Charrington:And I think that's very, very much possible. Um, I think the challenge, so there, there's a trend now called neurosense, which is largely bullshit if I may be frank. Um, and you know, people use EEGs. I used to use EEGs in my training. And also, I know people that run EEG companies, and they're very upfront. EEGs are useful for telling if you're asleep or if you're having a seizure. And it's very valuable to quantify sleep and quantify seizures. But it's not going to tell you if you're feeling up or low, right? It's just, it's not, can't do that. There's no signal there. And so there's a lot of crap out there.

55:46And so we've not waded into that space yet because I just, I have to do it right. Like I can't live with myself if I, if we don't do this right. But there's so many examples of this being true of sense, really being able to unlock emotions in one way or the other. And, um, we will get there and I think we will do it right. Um, but we're going to have to be very careful about how we quantify emotion, um, uh, which is its own thorny problem. But, uh, this is something I used to, I used to work on too. I love the topic.

56:16Sam Charrington:um and uh i'm imagining the the real estate agent going and spraying fresh baked chocolate chip cookie in the open house they already do that right i know they bake them is there an actual can oh yeah there's candles for sure yeah ah um a new car smell is like invented right um it's a thing right right but uh no a lot of this is also association right so same with the kimchi example it's like, well, that might be good or it might be the hearth, right? It's like, well, have you ever been in a home where a fire was lit? Like, does it smell like a burning building or does it smell like comfort and like, you know, marshmallows and hot chocolate, right?

56:54It just depends on what you're exposed to. But for sure, like the evidence I think is pretty clear that there are some scents that do things that are positive to your mood and it's almost physiological and can increase your focus or can increase your awareness or reduce your anxiety. Like, Like it's pretty clear to me, but I think we need to be really, really. Like aromatherapy? Yeah, I think aromatherapy has elements of really deep truth in it. And same with Ayurveda. Like I think that these are really old traditions. First of all, they're really appealing and they're beautiful to experience.

57:26It just smells nice. But like in kind of reading the research, there's nothing that's super clear cut. But like I just am of the conviction that there's some kernel of deep truth there. in the same way that like acupuncture now has this western equivalent called dry needling that's like actually therapeutic like acupuncture got there way earlier they just talk about it differently it's the same stuff and maybe some ways there's still things that haven't even been appreciated in in the western adaptations of it um but like i think that that correspondence will also happen for ayurveda and for aromatherapy and then also probably for the um the aromatic aspects of of herbal chinese medicine as well there's like you know plants are like our medicine and poison factories they make all the molecules that do good and bad things and all of our drugs like many of our drugs have some natural origin to them or they were inspired by a natural origin so like there's there's got to be some i just believe it i think there's got to be something there where scent has has real like powerful harnessable impact to uplift our mood and to make us feel better or perform better or whatever our desire might be that's actually, you know, realizable.

58:38And we just have to be, we have to be serious about it and we have to be thorough. That's all.

58:42Sam Charrington:Well, Alex, it's been great catching up with you and getting the download on Olfactory Intelligence. Super fun to talk about it. It's obviously wide ranging, but it's like we're pushing back the frontiers. And so like all the things you normally take for granted, like we You have to think all the way through. So I'm just thrilled to talk about this stuff all the time because I live it and breathe it. But it's fun to share with you, Sam. Thanks for having me on.

From the publisher

In this episode, Alex Wiltschko, founder and CEO of Osmo, joins the show to discuss his goal of giving computers a sense of smell and what it takes to build olfactory intelligence.

We explore the science behind smell, from the hundreds of olfactory receptors in the human nose to the challenge of mapping the relationship between molecular structure and odor, ensuring safety regulations are met, and building foundation models for smell. Alex explains how graph neural networks and advanced embedding spaces allow AI to capture the multi-dimensional structure of scents, grouping them into perceptual neighborhoods, and creating a machine learning representation that predicts how molecules smell.

We also cover how Osmo built the largest proprietary olfactory dataset from scratch to train a fleet of predictive models, and how olfactory intelligence could eventually power applications far beyond fragrance, including disease detection, emotion sensing, and consumer devices.

🗒️  Full show notes: https://twimlai.com/go/771.

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