Podcast · 34 episodes
This Week in AI
by Jason Calacanis · English
An experts-only AI podcast: Think the 'All In' podcast for AI. Jason + 3 CEO-level experts breaking down the news & trends.
Latest episodes
Why OpenAI Should Buy Off the World’s Top Mathematicians | E32The episode debates AI agents in commerce (Meta’s Muse shopping on Shopify via ShopPay; Amazon blocking Muse), and whether AI should accelerate math/science by solving problems faster than human…24 Sep 2026 · 1 h 17 min
The biggest AI threat still comes from humans | E31The episode debates whether AI should be slowed down, and argues the biggest near-term AI threat is human-driven misuse—especially agentic “swarms” used for cyberattacks and fraud.17 Sep 2026 · 1 h 13 min
OpenAI's chief scientist wants to slow down | E30The episode centers on OpenAI chief scientist Jacob Pachocki’s essay “An Alien Mind,” arguing for extreme caution and a possible need to slow down frontier AI development.10 Sep 2026 · 1 h 21 min
All episodes
Why OpenAI Should Buy Off the World’s Top Mathematicians | E32The episode debates AI agents in commerce (Meta’s Muse shopping on Shopify via ShopPay; Amazon blocking Muse), and whether AI should accelerate math/science by solving problems faster than human…24 Sep 2026 · 1 h 17 min · 29 chapters
The biggest AI threat still comes from humans | E31The episode debates whether AI should be slowed down, and argues the biggest near-term AI threat is human-driven misuse—especially agentic “swarms” used for cyberattacks and fraud.17 Sep 2026 · 1 h 13 min · 31 chapters
OpenAI's chief scientist wants to slow down | E30The episode centers on OpenAI chief scientist Jacob Pachocki’s essay “An Alien Mind,” arguing for extreme caution and a possible need to slow down frontier AI development.10 Sep 2026 · 1 h 21 min · 33 chapters
The real danger is the gap BETWEEN two robots | E29The episode debates the “real danger” in autonomous systems: not the robots themselves, but the handoff/gap between them (and between human oversight and automation).3 Sep 2026 · 1 h 30 min · 36 chapters
XBOW Founder: “Your Infrastructure is Not Safe” | EP 28The episode argues that open-weight AI models make cyberattacks easier and more continuous, leaving “your infrastructure is not safe” and the West unprepared; it also covers AI sovereignty via open…27 Aug 2026 · 1 h 11 min · 28 chapters
Anthropic is training to destroy your company | EP 27Debate over Anthropic’s public messaging and whether it implies power concentration; AI security risks from increasingly capable models; reward hacking and the Hugging Face incident; agentic AI…20 Aug 2026 · 1 h 17 min · 29 chapters
Why Anthropic is watermarking every word Claude writes | E26Anthropic’s plan to watermark every word Claude writes to comply with the EU AI Acts Transparency Code (effective Aug 2), using the C2PA open standard so the watermark persists when text is…13 Aug 2026 · 1 h 28 min · 41 chapters
Is open source AI really ahead of the frontier? 3 builders weigh in. | E25Whether open-source/open-weight AI is truly “ahead of the frontier,” and how builders think about cost, speed, intelligence, and AI sovereignty; includes news on Alibaba’s new model, U.S.6 Aug 2026 · 1 h 20 min · 28 chapters
Are we already in the Singularity? | E24Whether AI is already in the “singularity,” where value accrues across the stack (chips, memory, chips-in-space vs app layer), and how open-weight model pledges, regulation, and licensing terms…30 Jul 2026 · 1 h 7 min · 28 chapters
America already lost one AI race | TWiAI Ep 23U.S. policy and industry strategy around Chinese open-source AI models; agent reliability and security; simulation/digital world models; and AI infrastructure for routing models to cut cost while…23 Jul 2026 · 1 h 1 min · 22 chapters
Grok 4.5 and GLM-5.2 kick off Token Price Wars | E22AI model “token price wars” (Grok 4.5 and GLM-5.2 near-frontier quality at lower cost) plus enterprise implications: trust/risk from closed-model “tool takebacks,” need for open-weight/owned stacks,…16 Jul 2026 · 1 h 17 min · 27 chapters
What happens if China pulls the plug on open-source AI? | Ep 21Reuters-reported possibility that China stops releasing open-weight/open-source AI models globally, and how that could reshape the AI ecosystem, costs, security, and benchmarking.9 Jul 2026 · 1 h 21 min · 32 chapters
Mythos, Sonnet 5, GLM-5.2 Dominate the News Cycle | Episode 20This Week in AI Episode 20 covers a chaotic AI news cycle and the implications of U.S. model restrictions, open-source momentum, and the shift toward cheaper, “minimum viable intelligence” models.2 Jul 2026 · 1 h 11 min · 26 chapters
Are world models the unlock for Physical AI? | Episode 19Whether “world models” are the key unlock for Physical AI/embodied robotics, and how they help generality, long-horizon planning, and data collection (including in zero gravity).25 Jun 2026 · 1 h 13 min · 27 chapters
Why AI Models Aren’t the Product Any More | TWiAI Ep 18AI models aren’t the product anymore; the “product” is the agentic application layer (agents, evals, harness, UI) plus proprietary learning loops.18 Jun 2026 · 1 h 21 min · 27 chapters
Hermes Agent, NotebookLM & LiveKit Founders on the AI Agent Race | TWiAI 17This episode of This Week in AI (TWiAI 17) centers on the “AI agent race” and what agents mean for education, jobs, and product UX.10 Jun 2026 · 1 h 29 min · 33 chapters
AI Layoffs, Compute Costs & Agents | Naveen Rao & Alex Finn on This Week in AI Episode 16This episode of This Week in AI (Ep. 16) debates why AI costs are suddenly spiking and why layoffs are being blamed on “AI efficiencies.” Guests argue the problem isn’t just model intelligence or raw…4 Jun 2026 · 54 min · 18 chapters
"Nobody Lost Their Job to AI, Just the Promise of AI" - This Week in AI Ep 15Whether AI is actually causing job losses or mainly breaking careers via the “promise of AI,” plus how AI companies are building (compute, products, growth) and the risk of “reward hacking” in…27 May 2026 · 1 h 7 min · 27 chapters
Grads boo AI, Reese Witherspoon gets dunked + Karpathy joins Anthropic | TWiAI E14Roundtable on AI industry news and product strategy, focusing on Andre Karpathy joining Anthropic, “AI etiquette,” and how AI changes design and agent workflows.20 May 2026 · 1 h 39 min · 38 chapters
How the 1% Will Own Compute (and What It Means for You)The episode argues that AI progress plus reinforcement learning will decouple labor from value creation, causing layoffs and social unrest while compute becomes polarized—only the wealthy can afford…13 May 2026 · 1 h 8 min · 34 chapters
Is Anthropic a Cult? AI Beats ER Doctors & Recursive Self-Improvement | This Week in AI E12Anthropic “cult” speculation; recursive self-improvement timelines; AI as a medical co-pilot that can outperform ER doctors; healthcare workflow disruption (patient triage, EMRs, ambient scribing);…6 May 2026 · 1 h 17 min · 34 chapters
Cursor's $60B Deal, DeepSeek V4 & the Death of the AI Moat | This Week in AI E11The episode debates AI’s “moat” and where value accrues as coding/agents commoditize—covering OpenAI infrastructure spending vs revenue, AGI/superintelligence timelines, SpaceX’s option to acquire…30 Apr 2026 · 1 h 14 min · 33 chapters
Aravind Srinivas & Edwin Chen: The $1B Bootstrap, Apple's AI Edge, and Benchmarks | TWiAI E10Roundtable on AI coding and agentic “harnesses,” expert-model data work, Apple’s AI opportunity via Apple Silicon, and venture funding/bootstrapping dynamics.23 Apr 2026 · 1 h 20 min · 36 chapters
The Future of AI: Personal Agents, Taste & Private Data | Lin Qiao & Demi Guo | E9The future of AI “personal agents” and why judgment/taste (not raw productivity) will be the core human value; how private enterprise data should be activated via tuned open models; and whether AI…15 Apr 2026 · 1 h 14 min · 39 chapters