Could Your Supplement Routine Use an Audit? w/ Matt Titlow

16 Feb 2026 · 45 min · 20 chapters

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In short

Just Ingredients Podcast Episode 213: Could Your Supplement Routine Use an Audit?

Overview In this episode, host Karalynne Call is joined by Matt Titlow, CEO of Compound Solutions, to discuss the significance of supplements, particularly their absorption and impact on gut health. The conversation unpacks common misconceptions about supplements, highlights trending ingredients, and provides practical tips for improving gut health.

Key Topics

  1. Bioavailability
  2. Definition: Refers to the degree and rate at which a substance (e.g., nutrient) is absorbed into the bloodstream.
  3. Importance: Not only the type of supplement matters but also how well the body can absorb it.
  4. Absorption Factors:
  5. Gut Health: The condition of the gut can significantly influence nutrient absorption.
  6. Forms of Supplements: Liposomal formulations are designed for better absorption, but not all supplements require this form to be bioavailable.
  1. Gut Health
  2. Second Brain Concept: The gut is often referred to as the "second brain" due to its profound impact on overall health, including digestion and mental clarity.
  3. Indicators of Gut Issues: Symptoms like bloating, diarrhea, or constipation may indicate leaky gut or gut dysbiosis.
  4. Importance of Fiber: A diet rich in fiber from vegetables is crucial for gut health as it promotes fermentation and the production of short-chain fatty acids (SCFAs) like butyrate.
  1. Butyrate
  2. What It Is: A short-chain fatty acid that supports gut lining integrity and serves as fuel for colon cells.
  3. Sources: Produced through the fermentation of dietary fiber in the colon.
  4. Supplementation: Taking butyrate as a supplement can help improve gut health, especially in individuals with digestive issues.
  1. Trending Supplements
  2. NAD (Nicotinamide adenine dinucleotide):
  3. Function: Essential for energy production and declines with age.
  4. Usage: NAD3 as a supplement can help maintain and enhance NAD levels.
  5. Berberine:
  6. Role: Known for its potential to aid in blood sugar control and metabolism.
  7. Connection to Gut Health: Berberine affects gut hormones that regulate satiety.
  1. Practical Tips for Gut Health
  2. Exercise Regularly: Movement supports gut function and overall well-being.
  3. Consume Vegetables: A fiber-rich diet is vital for promoting a healthy gut microbiome.
  4. Consider Supplements Wisely: Focus on quality and bioavailability; supplements should complement a balanced diet.
  1. Choosing Supplements
  2. Trustworthy Brands: Look for transparency in product labeling, including branded ingredients that have undergone clinical testing.
  3. Testing and Personalization: Individuals should test their nutrient levels and supplement based on specific deficiencies rather than following trends.

Key Takeaways

  • Gut Health is Fundamental: Before investing in supplements, one must ensure gut health is optimal as it directly affects nutrient absorption and overall health.
  • Whole Foods Over Supplements: Prioritize a diet rich in whole foods to provide necessary nutrients before considering supplementation.
  • Individual Needs Vary: Each person's nutritional needs are unique; therefore, personalized approaches based on testing are essential for effective supplementation.

Episode Conclusion The conversation emphasizes the importance of understanding the role of gut health in nutrient absorption and overall wellness. Karalynne and Matt encourage listeners to be informed consumers, prioritize whole foods, and consider dietary supplements as part of a holistic approach to health.

Connect with Matt Titlow

  • [Compound Solutions Website](https://compoundsolutions.com/)
  • [Matt’s LinkedIn](https://www.linkedin.com/in/matt-titlow/)
  • [Compound Solutions Instagram](https://www.instagram.com/compoundsolutions/)

Discover More

  • Follow [@just.ingredients](https://www.instagram.com/just.ingredients) on Instagram for more insights and content related to health and wellness.
  • Check out the [Just Ingredients product line](https://justingredients.com/) available now at Target stores nationwide.

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

Tap a time to open that second in VO

Meet Matt Titlow and His Journey

0:45 to 1:52

Matt shares his background and passion for ingredients in the supplement industry.

“So this is a longer story, so I'll try to make it a little bit shorter.”

Understanding Bioavailability in Supplements

1:52 to 3:54

Discussion on what bioavailability means and its importance in supplements.

“So sometimes trying to simplify it can help.”

The Role of Gut Health in Nutrient Absorption

3:54 to 5:26

Exploring how gut health affects the absorption of supplements and nutrients.

“okay so you're saying then for a supplement to be bioavailable it's not only the supplement and making sure that it's maybe liposomal or it's been tested to get to the blood.”

Signs of Gut Issues and Their Impact

5:26 to 7:14

Identifying signs of gut issues and their implications on overall health.

“People talk about the bioavailability of creatine and increasing it.”

Solutions for Gut Health: Exercise and Diet

7:14 to 9:10

Recommendations for improving gut health through exercise and food choices.

“And so should people not take supplements while they are dealing with gut issues?”

The Importance of Butyrate for Gut Health

9:10 to 11:12

Understanding butyrate's role in gut health and its benefits.

“So exercise, eat a vegetable and take your probiotic complex.”

Postbiotics and Their Role in Gut Health

11:12 to 13:03

Exploring the significance of postbiotics and their benefits for the gut.

“So I think everybody needs to start with that, though.”

Connecting Gut Health to Mental Health

13:03 to 14:05

Discussing the relationship between gut health and mental health.

“What if we ate a lot of sugar and processed foods?”

The Gut-Brain Connection

14:05 to 15:49

Explore how gut health impacts mental health through neurotransmitters.

“Can you imagine putting sand in your car and saying, let's go?”

Understanding Supplement Absorption

15:50 to 18:10

Learn about the importance of gut health and trust in supplement quality.

“Okay, so people now know they're going to exercise, eat their fiber, take their butyrate to heal their gut lining, help their gut.”
Show all 20 chapters

Navigating the Supplement Industry

18:11 to 22:20

Discuss the challenges and trust issues consumers face in the supplement market.

“testing in third parties, exactly what you just said.”

Identifying Essential Supplements

22:21 to 24:55

Learn how to determine which supplements are right for you based on individual needs.

“So out there on social media, everybody is teaching like, oh, vitamin D is amazing.”

The Rise of NAD Supplements

25:58 to 28:00

Understand the trend of NAD supplements and their role in energy production.

“If an average American could only buy three supplements, what three would you choose?”

Understanding NAD and Its Importance

28:00 to 29:19

Learn how NAD supplements can play both offensive and defensive roles in health.

“In other words, can you imagine playing in an orchestra one single instrument?”

The Role of Diet and Exercise in Supplement Effectiveness

29:20 to 31:35

Discover the impact of lifestyle choices on the effectiveness of supplements.

“So a lot of NAD supplements out there do not have NAD3 in it.”

Gut Health and Metabolism Connection

31:36 to 34:05

Explore the relationship between gut health and metabolic processes.

“It's just, yeah, we're too different to have everything work every time.”

Liver Health and its Impact on Metabolism

34:06 to 36:37

Understand how liver function affects metabolic health and what tests to consider.

“So many women tell me that, like, I just never feel full, so I can keep eating and eating.”

Berberine vs. GLP-1: Natural vs. Pharmaceutical Solutions

36:38 to 39:16

Evaluate the differences between natural supplements like berberine and GLP-1 medications.

“They're sort of doing the same thing, not necessarily.”

The Importance of Potassium in Electrolytes

42:00 to 43:58

Learn why a potassium to sodium ratio is crucial for everyday health.

“I just happen to feel amazing on those first thing.”

The Role of Community in Health and Wellbeing

43:58 to 44:23

Explore how community and relationships impact health and wellness.

“What is the best ingredient you've found to life?”
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Transcript

Automatic transcript. May contain errors.

0:00Matt Titlow:Welcome to the Just Ingredients podcast. I'm Cara Lynn, and here we dive deep into the journey of healing and wellness. If you're ready to learn, feel empowered, and take charge of your health, you're in the right place. Welcome back to the show. Today, I am really excited because I have Matt Titlow here with me, and he is the CEO of Compound Solutions, which is like an ingredient house, is what you just said. They provide the most amazing ingredients. And so we're going to talk about supplements today and all things supplements and all the myths and misconceptions and why some people absorb them and why some people don't.

0:39Matt Titlow:And so welcome to the show.

0:41unknown host:Thanks for having me. Looking forward to it.

0:43Matt Titlow:I'm curious. So how did you get interested in ingredients?

0:46unknown host:So this is a longer story, so I'll try to make it a little bit shorter. But actually, my father got in the industry about 40 years ago. He started Compound Solutions 26 years ago. I started 22 years ago. So in the end, I grew up in it. OK. And then I realized that I just wanted to be the liaison between the science and the consumer. And so that is really my role while I'm the CEO on that liaison from the clinical research to how does that actually fit the brand, the ethos of, let's say, just ingredients and how does that ingredient support the consumer?

1:22Matt Titlow:Well, you are a wealth of knowledge, and I'm sure you learned it over these 22 years of talking to all the scientists and learning about all the ingredients and how they intermix and things like that. And so let's start with supplements. Like I said, you know so much about supplements. But one of the things I want to talk about, it's really trendy right now to hear like, oh, these are really bioavailable supplements or more easily absorbable. Or you'll hear like some people say like, well, I can absorb them, but so-and-so couldn't absorb them. So what is all this talk? Like, what is bioavailability?

1:55Matt Titlow:Why is this an issue?

1:56unknown host:Right. So this is a little bit complex. So sometimes trying to simplify it can help. And I think there are two ways to go with this. And one is just strict bioavailability is what they're looking at is testing blood. So does that polyphenol, like grapeseed extract, get into your blood? But there are other aspects to it. Like, do you actually absorb your ingredients, your nutrients, your vitamins and minerals from your vegetables, for example? And so in the supplement industry, we've got into like liposomes, if someone's heard of that. Just an ingredient encased in fat, let's just say, to try to deliver that into the bloodstream.

2:33unknown host:Now, does that get to the muscle tissue or the heart tissue or the brain tissue? That's a whole other question. So we've really kind of limited it to the blood in terms of bioavailability. Now let's just talk absorption. A lot of like consumer, we're just thinking in the mind of the consumer, we got to be thinking, can I actually process that food? And that hits the gut. So if we just skip supplements for just one second and skip bioavailability, that word and the word liposome, and just think, can I actually take the nutrients from that broccoli and flourish? that's a function of our gut microbiome yeah that's the broccoli being bioavailable being bioavailable meaning i can actually ingest the broccoli in my colon i can actually ferment that and i can take those undigested fibers create short-chain fatty acids and break down other nutrients with my bacteria that goes through the liver and then into the blood and then that is what kind of quote unquote makes us healthy because those nutrients are like signals like I'm talking and you're listening you talk and I'm listening these are signals well you have receivers receptors well the receptors in the brain in the heart in the muscle they're super happy with broccoli they're a little less happy with skittles right so yes this is the gut microbiome

3:57Matt Titlow:okay so you're saying then for a supplement to be bioavailable it's not only the supplement and making sure that it's maybe liposomal or it's been tested to get to the blood. It also plays a role in the person, meaning the person needs to have good gut health.

4:15unknown host:Both.

4:15Matt Titlow:So let's talk about both of those then, really. Okay. Are there supplement companies making cheap supplements that we know won't get to the bloodstream?

4:24unknown host:Yes. Without naming names, there are liposomes that aren't liposomes. So they say it's more bioavailable when it's not. So that's very well known in our space, in the ingredient space, but not said out loud. Well, we just said it out loud.

4:41Matt Titlow:It's like a marketing tool.

4:43unknown host:It's a marketing tool.

4:44Matt Titlow:A marketing scam, I might say.

4:46unknown host:You could say that. There's also just very real conversion issues. So like, let's just take B12. You can call it B12, but there's cyanocobalamin and there's methylcobalamin. Your body readily uses methylcobalamin, not readily using cyanocobalamin. Those are both B12. So that's a real life example where it's the same name for a supplement, but yet one is more bioavailable in the body and another. So you want that, like a just ingredients product to have methylcobalamin, for example.

5:19Matt Titlow:And I was going to say, we use the methyl form for all of you listening. cells. But it doesn't have to be liposomal to be bioavailable. That just increases.

5:29unknown host:That's a huge myth. Huge myth. So let's just take creatine. People talk about the bioavailability of creatine and increasing it. It's already bioavailable.

5:39Matt Titlow:Okay.

5:39unknown host:It's just, they're creating a solution for a problem that doesn't exist. It's like a solution looking for a problem.

5:46Matt Titlow:Interesting.

5:46unknown host:So just use methylcobalamin. For example, you don't need to who look for a liposomal methylgobalamin, it's already used.

5:55Matt Titlow:Okay. So a lot of things out there have been tested to be bioavailable.

6:00unknown host:Right. It gets into the blood and then through the blood, gets into our system and functions.

6:05Matt Titlow:So let's go back now to the person, because some people aren't really going to absorb the nutrients or the ingredients or the supplements in this case if they've got gut issues. Right. And so how does someone even know if they have gut issues? All right.

6:20unknown host:When you get into gut issues, you have very flowery language. So we're going to go right into it. Okay, let's go. But I really believe that when we go to the doctor, we are always tested for height, weight, blood pressure. But the next question for a vital sign should be, how are you pooping? If you don't poop well, how in the world would you be healthy? It just seems really odd to say, gosh, I'm feeling great. Everything's great. I'm thin. I'm exercising. Everything's great. And by the way, I haven't pooped in a week. Or I have diarrhea all the time. It just doesn't make sense.

6:56Matt Titlow:That's usually the first symptom expressing what's underlying.

7:01unknown host:And that is like some sort of gut inflammation. And what does that mean? It usually means bloating or irregularity and irregularity. Those are the two classics.

7:11Matt Titlow:So I tell people if they're bloating after they eat, if they're bloating at the end of the night, if they're running to the bathroom after they eat all the time, they've got most likely what's called leaky gut or a lot of people call it that.

7:24unknown host:Exactly. Yeah.

7:25Matt Titlow:And so should people not take supplements while they are dealing with gut issues? Is it beneficial?

7:32unknown host:Supplements can help. I would do two things. One is I would go for a walk. I would just exercise just anything. right anything to get the body moving that would be a one number one and that's going to help the

7:44Matt Titlow:gut that's going to help the gut okay you don't hear most doctors say that about the gut right

7:48unknown host:nature is a system we are a system when you change one thing in the system the whole system can change love it let's take exercise yes can help the gut the next thing is i would eat vegetables because vegetables are what are you know breaking down into short-chain fatty acids what is that it's butyrate. Butyrate is that linchpin in the gut lining. So why do we care about the gut lining? Well, because believe it or not, our gut resides outside the body. From the mouth to the anus, you're outside the body.

8:20Matt Titlow:Okay. I haven't heard it like that before, but I like that. So once you ingest, let's say broccoli, and you break down that into, let's say, short chains

8:32unknown host:like butyrate and that enhances your gut lining, what then goes from your gut lining into your blood is, quote, positive or good. When you have a very thin lining because a lack of vegetables and a lack of butyrate, a lack of fiber and a lack of butyrate, well then it can get a little leaky. That thick layer becomes thin and that's when you get pathogens and, quote, bad things, bad pathogens, bad bacteria into your bloodstream and then that goes throughout the system. That's the whole leaky gut situation, that's a whole absorption thing with any nutrient. And that's what would harm your absorption of anything, let alone a supplement.

9:10unknown host:So exercise, eat a vegetable and take your probiotic complex. All right.

9:15Matt Titlow:So I think most Americans are dealing with leaky gut, don't you think? I do.

9:20unknown host:And I don't think it's opinion. I really think that if 95 % of Americans are deficient in fiber, how would they not have some form of leaky gut or gut dyspiosis?

Read the full transcript

9:33Matt Titlow:Because that fiber is feeding the good bacteria in the gut.

9:37unknown host:And feeding that gut lining.

9:39Matt Titlow:Okay, let's talk about this gut lining also, because leaky gut in simplified forms, in simplified language, I should say, means that toxins are getting out of the gut and into the bloodstream, correct? Yes. And so since they're getting into the bloodstream, this is causing inflammation. And the inflammation is the root cause of so many different health issues out there, correct? Yes.

10:01unknown host:Yes.

10:02Matt Titlow:So everybody basically needs to start with their gut and fixing their gut before they're out there spending thousands of dollars on supplements.

10:10unknown host:Yes. I believe it's the window into health. I think it's the master switch to wellness. Okay.

10:14Matt Titlow:So you talked about butyrate. And I didn't know what butyrate was until I started getting into the nutrition space and, you know, learning about that. So I don't know how many just general Americans know what butyrate is. So tell them what butyrate is.

10:28unknown host:Yes. So when we eat a vegetable, again, I keep picking on broccoli, but we can pick on another one. It's fine. We can do bok choy. But in all seriousness, that breaks down in the colon. It ferments. And that fermentation process creates a mixture of short chains. And those typical ones that we talk about are butyrate, acetate, and propionate. So butyrate is primarily responsible as fuel for the colonocytes, which is those cells on the gut lining in the colon. That is their fuel. So like while our brain might like glucose, our gut prefers butyrate.

11:08Matt Titlow:Okay.

11:09unknown host:This is crucial.

11:10Matt Titlow:That is crucial. And doesn't the butyrate then, because the cells love it, that helps rebuild the gut lining?

11:17unknown host:That is exactly what happens.

11:19Matt Titlow:So I think everybody needs to start with that, though. I mean, like, well, of course, eating fiber and moving. Yes. But so many people don't think about taking butyrate as a supplement where butyrate can help fix that gut lining.

11:32unknown host:I am on your page. I don't know if you can go over 100%, but I'm on your page at least 100%. Yes.

11:38Matt Titlow:Okay. And butyrate a lot of times is in the postbiotic. If you look at a pre, pro, and postbiotic complex, it's in the post part of it.

11:48unknown host:True. Yes.

11:50Matt Titlow:Okay. So, all right. So we actually got an ingredient from you called core biome that we put in our postbiotic because I'll tell you what was going on. I was looking for a good prebiotic and I was like, OK, everything that I see is a prebiotic and probiotic, but I could not find anything out there that was pre, pro and post.

12:10unknown host:Right.

12:10Matt Titlow:And so I went to my food scientist and I was like, why is no one including the postbiotic? Like this is ridiculous to me. This is the most important part. We're missing it.

12:19unknown host:Right. Right.

12:19Matt Titlow:And so we went looking for a good postbiotic and found your core biome. And so why don't you tell them what the core biome is that we've put in our complex?

12:29unknown host:Yes. So it is a, what we say, a bioavailable butyrate in the colon. In other words, it gets to the colon where it's needed. So that directly feeds those colonocytes for fuel. And the reason why this is fuel is critical isn't just because of the gut lining. I would really like to impart the fact that this fuel is unlike glucose for the brain. In other words, the gut doesn't fuel off of glucose. It doesn't fuel off of sugar. This is such a critical point. So what if we didn't eat enough fiber? What if we ate a lot of sugar and processed foods? You could be starving in your gut. And when you're starving in your gut, think of all those signals that are sent out from the gut that aren't ideal.

13:16unknown host:And where do they send? Where do they go? To the brain, to the heart, to the skin. In other words, if you exercise, if you eat a vegetable, if you take your postbiotic complex, right, with core biome, what happens to skin, brain, heart? This is like the soul of health is the gut.

13:33Matt Titlow:So the receptors in your skin, your brain, your heart can better receive them when your gut is not being starved.

13:41unknown host:That's my view, yes.

13:42Matt Titlow:Well, and so a lot of people out there, you did a better explanation because a lot of people just say that sugar feeds the bad bacteria and fiber feeds the good bacteria. And that's the simplified form of what you're saying is sugar is just going to starve it because it's not fuel. Right. So we need the fuel, which is the fiber and the butyrate to send out those signals to our brain and our heart and our skin and things like that.

14:04unknown host:Yes. Can you imagine putting sand in your car and saying, let's go?

14:09Matt Titlow:Yeah, that's crazy.

14:10unknown host:It's crazy, right?

14:11Matt Titlow:Okay, this is a tangent, though. I am really an advocate about mental health just because I dealt with depression. But a lot of depression, I think, could be helped with butyrate and with fiber and with exercise because how's the brain getting the right signals from the gut if we're not fueling the gut to send those signals to the brain?

14:30unknown host:Yes. And what's unbelievable is that it's not Bluetooth. From the gut to the brain, there's an actual nerve, vagus nerve. And people know about now the vagus nerve and vagal tone. So I don't know why when we have a mental issue, we're not going to the gut.

14:48Matt Titlow:Yeah.

14:49unknown host:Because I would argue it's the first brain, the second brain, but it's the first brain. And it's not just that the signals are going, it's that the actual serotonin and dopamine are made there.

14:59Matt Titlow:I was going to say that's the second part is neurotransmitters are made there. Right. And not even neurotransmitters, hormones are regulated, told what to do, all sorts of things with the gut.

15:08unknown host:Exactly. They are directing. It's the orchestra. And it's the conductor conducting the orchestra. And meaning the orchestra is really just signals going throughout the body. That's why if we exercise, everything gets healthier. Like if you exercise, your skin will get better. How does that happen when we're thinking exercise and muscle? Well, if you eat vegetables or take your postbiotic complex, how does that influence the skin? How does it influence the brain? What influences the gut first?

15:36Matt Titlow:Yeah, and I don't think people correlate that. Like, oh, I'm working out, so that's going to help my gut, which is then going to help my skin. No one thinks about that. They're thinking like, oh, I'm burning X amount of calories or I'm lifting this much weight. Right.

15:48unknown host:It's too indirect.

15:49Matt Titlow:Oh, I love that. Yeah. Okay, so people now know they're going to exercise, eat their fiber, take their butyrate to heal their gut lining, help their gut.

15:59unknown host:Yeah.

16:00Matt Titlow:And then they should start taking other supplements?

16:03unknown host:I think you could take it simultaneously. I would argue that absorption or benefits will improve when your gut is healed.

16:16Matt Titlow:Yeah.

16:17unknown host:Less bloating, better regularity are symptoms of better gut lining.

16:22Matt Titlow:Okay. I do want to move on, but I know I'll get this question. So before I move on to the next topic, I know people are going to say, but wait, okay, I know how to get my body more absorbable or to absorb them better, but is there a way to look on the label of the supplement or how am I going to know if it's an absorbable form of vitamin I'm taking?

16:41unknown host:You know, I think that's just about trust and the whole world revolves around trust. And if you look at some lose 10 pounds in 10 days sort of a supplement, it's too good to be true. If you look at the supplement and it says, and there's no one to call, there's no phone number, you can't return it. It's just too much, right? If they don't disclose what's in there, too many proprietary blends, it's too good to be true. So I think the fact that, for example, people can contact you on 87 different social channels.

17:15Matt Titlow:I was going to say they can DM us and customer service.

17:19unknown host:I think that's a part of it. It's just trust.

17:22Matt Titlow:Well, okay, you know what's interesting about the supplement industry? Talking about trust.

17:27unknown host:Yes.

17:28Matt Titlow:You really can put anything in those pills and there's no one really to catch you.

17:32unknown host:The issue is we have laws, but we don't have enough enforcement.

17:37Matt Titlow:Yeah, so we make supplements and they go out the door and to the consumer. And I'm checking and third-party testing and doing things, but what are other companies doing? They could be putting whatever they want in there and sending them out.

17:51unknown host:We do run into a little bit of Wild West. Boy, has it improved over the last 10, 15 years because I've been in it more than 20. So it has improved dramatically. But the Wild West still happens and you're relying on ingredient suppliers like us at Compound Solutions. trusted entities like yourself and brands who are really focused on the ingredients and contract manufacturers who are actually abiding by good manufacturing practices, testing in third parties, exactly what you just said. It's just trust at the end of the day. It just keeps coming back to that.

18:24Matt Titlow:Well, which gets overwhelming for the consumer because they go to Costco and see all these brands, like say vitamin D, they've got seven different options and they're like, oh, which one do I choose? It's tough. And it is crazy to me because I will tell you, I don't know if you've heard me tell this story. I've told it multiple times. We were testing turmeric and we had lots of turmeric brought in from lots of different suppliers. And there were really bioavailable sources of turmeric all the way to like a ton of rice powder with a little bit of maybe yellow turmeric sprayed in there. And it was like hardly any turmeric, but they both were called turmeric.

19:01Matt Titlow:Turmerics.

19:02unknown host:Botanicals are notoriously cut.

19:04Matt Titlow:They're both called turmeric, but one is just complete rice powder with a tiny little bit of turmeric sprayed in there.

19:10unknown host:Yes, that's exactly. Yeah.

19:12Matt Titlow:But they're going to go sell at Costco or wherever for the same amount of money,$49.99.

19:17unknown host:Yeah, it is ridiculous and terrible. And I just apologize for this moment that we're in.

19:25Matt Titlow:Bottom line is consumers just have to find brands they trust.

19:28unknown host:That's it. I wish I could make it simple. do you know what's on the label? Just number one, is it actually disclosed? And number two, can you contact them?

19:38Matt Titlow:Okay.

19:40unknown host:Those are huge.

19:41Matt Titlow:I also think there's one other maybe.

19:42unknown host:Please tell, please tell.

19:43Matt Titlow:But maybe you think differently. What if there's a branded ingredient on the label? Does that give a little bit more trust to the people?

19:51unknown host:A lot more.

19:52Matt Titlow:So let's talk about branded ingredients because like Core Biome is a branded ingredient in our pre-pro-post complex.

19:59unknown host:Yes. So to give a little background on just, so what does that even mean? Right? Like, why would we brand us and you? Right? Like, why would we collaborate like this? It's really a reference point on value. So let's just take toxicology, grass. So to introduce a new ingredient, oftentimes you have to do toxicology, which just means you have to make sure it's safe. Okay. And grass means generally recognized as safe. Okay. Typically, that's in the$300 ,000 to$400 ,000 range. And then you have to do a clinical trial to make sure that it actually works. And that could be gut models. It can be in humans.

20:39unknown host:You do various things. But you typically can't do any human trial under$100 ,000. That would be minimum, minimum. So if you are doing some sort of grass certification, clinical trials, you're typically into it about a half a million dollars pretty easily. So that barrier to entry is significant for someone who wants to just trade and make some money quickly. That is not a fly-by-night entity that just wants a quick hit and quick money. So that brand and patent associated with that ingredient typically indicates a significant amount of money and time. What I just indicated to you is years. Tip again the order of three to get all that done.

21:30Matt Titlow:Okay. So we use branded ingredients from you that then show the consumer, hey, these have been clinically tested. These have been shown safe, effective. That's why we're choosing them.

21:41unknown host:That's exactly.

21:42Matt Titlow:So that's another thing that they can look for on labels.

21:44unknown host:A hundred percent. And it's an indication of not just the value in the product, but the value that the brand places on their product, which I believe is a value that you're placing on your consumer.

21:58Matt Titlow:Because they're not cheap.

21:59unknown host:They're not cheap.

22:00Matt Titlow:Because of all the studies and things that have gone into them.

22:03unknown host:And you're saying my consumer, my customer, is valuable enough for me to invest in her or him.

22:09Matt Titlow:Yeah. Well, I want to make something effective. I don't want to make the crap turmeric sprayed on some rice powder.

22:16unknown host:Exactly.

22:17Matt Titlow:Okay. Well, good to know.

22:19unknown host:Yes.

22:19Matt Titlow:All right. So now here was my second question I was going to get to, but we went that little tangent. So out there on social media, everybody is teaching like, oh, vitamin D is amazing. Methyl B vitamins is amazing. Magnesium, omega-3s. It gets overwhelming. By the time you're hearing all the amazing benefits of all the supplements, people are like, oh my gosh, I'm taking$500 worth of supplements or I'm taking 15 supplements a day. How do people know what they should take?

22:47unknown host:Wow. That is a big question. first is i would like to go back to what you have been preaching from day one that is whole food right eating whole foods after that we're talking supplements can't out supplement a bad diet

23:05Matt Titlow:what you said we've heard that all the heard that a lot exactly because you said how would i

23:10unknown host:kind of narrow it down yeah how do people know what i trust well how do how does the consumer

23:16Matt Titlow:know what to take because I'm like, okay, yeah, magnesium, we all need that. Okay, omega-3s, we all need that. Vitamin D, yeah, we all need that. Vitamin C, yeah, that's great for collagen. Okay, I'll take that. Yep. You know what I mean?

23:29unknown host:Man, I would think about maybe your goals. I would maybe start with myself, right? Like, am I getting the protein I think I need between me and my nutritionist, my doctor, me and my neighbor? What would I think for my body? How much protein do I I think I need, like, what are my goals, right? And once you have your goals, I think you can then lead into what you are supplementing. So let's just take your doctor. You get your cholesterol and your vitamin levels and things of this sort. You look at your division D or K or something along these lines. Well, then supplement with it, right? But I think it's about you and then about the supplement.

24:12unknown host:I think that's how I'd best answer it.

24:14Matt Titlow:That is good. because I always tell people, test, don't guess. Otherwise, if you're looking at all these amazing benefits, you'd be taking 20 supplements.

24:22unknown host:Right.

24:22Matt Titlow:But I know like a lot of people are low on vitamin D, but I personally am usually high on vitamin D, so I don't take it. But there's a lot of Americans that do need vitamin D.

24:31unknown host:Right. I use Function Health. I use Function Health just so I can get a bunch of different tests. Not because I like that one or another one. It's just simply because I'm looking for a lot of tests and at a reasonable price. So if you're a doctor or you can do or you want your own, great. But I use that simply to get a lot of inputs. So I'm testing, not guessing. And then I supplement when I'm shorting.

24:55Matt Titlow:Let's take a quick break to hear from our show sponsor. For a long time, the food industry told us this is just how it's done. We chose another path, products made with real food and transparent formulas without natural or artificial flavors, unnecessary fillers, or questionable sources. As a certified nutritionist and mom, I saw how much of what we consume every day affects our energy, our mood, and our ability to show up for our lives. I wanted better options, not just for my family, but for yours. That's why I started Just Ingredients. And now I'm so excited to share that Just Ingredients is available at Target stores nationwide.

25:33Matt Titlow:You can find 15 of our best sellers at Target, including select protein powders, electrolytes, pre-workout, and supplements. designed to support everything from daily energy to mood and sleep. We're taking the guesswork out of clean living. Our most loved products are now available at the place you already shop. Find just ingredients at Target in stores and online. Now back to the show. Okay, I'm curious. If an average American could only buy three supplements, what three would you choose?

26:07unknown host:Wow, three supplements. That is huge.

26:10Matt Titlow:I know that's so hard, huh? Someone asked me that the other day.

26:14unknown host:Wow. All right. I would do a multifiber.

26:17Matt Titlow:Okay.

26:18unknown host:Because I believe it starts in the gut.

26:21Matt Titlow:Okay. Makes sense. After a multifiber, I would be between... Magnesium.

26:28unknown host:Magnesium.

26:29Matt Titlow:Good guess.

26:30unknown host:And I'd be between magnesium, D3K2, and protein.

26:35Matt Titlow:Oh, of all those.

26:37unknown host:I'd be circling those.

26:38Matt Titlow:Yep. I know. It was really hard for me. I circled those. I circled methyl Bs, omega-3s. Yes. Yeah.

26:46unknown host:I would like to reciprocate. Yeah. So you added on the B vitamins and methyl B vitamins. And omega-3s. Omega-3s. Anything else?

26:52Matt Titlow:Nope. Those were. So really I had like five because it was too hard to narrow it down to three. So I was just curious.

26:58unknown host:And I take those, by the way.

27:00Matt Titlow:I do too. So. Yeah. Okay. I have a question for you about something that's trendy out there right now.

27:05unknown host:Okay.

27:06Matt Titlow:So NAD.

27:07unknown host:Yes.

27:08Matt Titlow:NAD is a trendy supplement. We use another branded ingredient of yours for our NAD called NAD3.

27:16unknown host:Right.

27:16Matt Titlow:So can we just talk about first maybe why NAD is trendy? I mean, we know the Kardashians are using it and it's gotten all over and people are doing NAD IVs. But why are people loving this supplement lately?

27:30unknown host:Yes. Well, it's involved in energy production. Let's call it, it's involved in the electron transport chain, which is basically saying energy production. And this declines with age. And so when you have a decline in, let's say, energy, let's say, mitochondrial function, which is kind of your engine, that decline in engine, and your engine kind of creates a decline in all health. So if your engine is declining, they're thinking, well, let's get that engine back. Let's recharge. Let's just press on the gas again. and that's your gas for yourselves. Well, it's very reductionist. In other words, can you imagine playing in an orchestra one single instrument?

28:14unknown host:It sounds silly. Like you don't just play like a horn and that's an entire orchestra. Right. You have violins and cellos. Well, just like nature, just like an orchestra, we play a system. And so you need to not just play offense, which is NAD. and you play defense, which is a decline in NAD status. So you don't want to take like vitamin C and smoke a cigarette. That would be really ironic, right? You have an antioxidant.

28:44Matt Titlow:There might be some people that do it.

28:46unknown host:Antioxidant, right? Well, just like NAD. You wouldn't want to be sedentary and then take an NAD supplement because you're playing, you're contradicting your sentence. So NAD3 exists to play defense, meaning prevent the declination, and the decrease in NAD.

29:03Matt Titlow:Okay.

29:04unknown host:While also up-regulating your NAD status. It's playing both ends, offense and defense. Okay. So your total NAD status is improved.

29:16Matt Titlow:That's what the NAD3 is doing.

29:18unknown host:That's exactly what it's doing.

29:19Matt Titlow:Okay. So a lot of NAD supplements out there do not have NAD3 in it. Right. And so are they useless?

29:27unknown host:I don't think they're useless. You just want to make sure that you'd be complimenting it. In other words, you'd want to take it and exercise or take it and...

29:39Matt Titlow:Red light.

29:41unknown host:Red lighter. Yeah. Do something else that isn't oxidative, right? Don't take an NAD supplement and then start eating Snickers and Twinkies.

29:50Matt Titlow:Okay.

29:51unknown host:So NAD3 is about kind of counteracting any sort of decline, like pollution. for everyday life. We have microplastics, things that are oxidative. We're trying to prevent the NAD decrease, NAD plus decrease that would occur from that oxidative stress while also upregulating your boost in NAD plus.

30:15Matt Titlow:Okay. So question for you, because a lot of people say NAD only works if it's injected right into the bloodstream.

30:22unknown host:I don't believe that. There are a couple studies that show that whether it's ours, NAD3 or NMN or NR does increase NAD plus in the blood.

30:34Matt Titlow:So we have clinical studies showing that.

30:36unknown host:Right.

30:37Matt Titlow:Okay. But again, like you said at the very beginning, you would need good gut health for it to make it through the gut to the liver into your bloodstream.

30:44unknown host:That's exactly. In other words, it might do nothing if you are, let's just say, sedentary, eating a high sugar diet, and have a leaky gut.

30:56Matt Titlow:So if you're eating Oreos all day long and not working out, of course, NAD is not going to work.

31:00unknown host:It's not going to do anything. And that is kind of what a lot of supplements are, right? A supplement, you just said a minute ago, you can't out-supplement a poor diet.

31:09Matt Titlow:Yeah. And that's it. So again, that goes back to why some people say, oh yeah, I took like the adrenal complex and it helped me so much. and then others are like, oh, it didn't do much for me. Well, I'd have to go ask this person, well, what are you eating every day? Are you exercising? Are you getting good sleep? All those things.

31:29unknown host:Exactly. 100%. We're all too different to have a one-size-fits-all. I mean, our gut microbiomes are so individual, let alone genetic differentiation. It's just, yeah, we're too different to have everything work every time. Think caffeine. Not everyone responds to caffeine.

31:50Matt Titlow:That is for sure.

31:51unknown host:Right. How would we all respond to like 100 % of people, 100 % respond the exact same way to anything? Fiber, adrenal complex, caffeine just doesn't, it's not rational.

32:02Matt Titlow:That's a good analogy because caffeine keeps me awake for hours and hours and it doesn't even affect my husband. So there we go. Exactly. Okay. Talking about trendy topics, because we just talked about NAD. Yes. I am curious about berberine.

32:17unknown host:Yeah.

32:18Matt Titlow:But I'm also curious, metabolism, speeding up metabolism, metabolism health is a huge topic right now out there as well.

32:26unknown host:Yes.

32:26Matt Titlow:I think because of GLP-1s and berberine. And so let's first start with the connection. Is there a connection with the metabolism and the gut health?

32:36unknown host:Yes. so when we talk about like gut health and we think about glp1s those satiety hormones are expressed in the gut like the small intestine so this is very very important to note right like just want to pause on that that they're expressed in the gut i also want to pause and and express that short-chain fatty acids like butyrate are what signal those satiety hormones those receptors to respond. So think fiber breaking down the short chain fatty acids like butyrate. So this is very, very, very important. The second thing that I'd like to talk about is the fact that metabolism is really a function of how we can convert food into energy.

33:23unknown host:And the food and the energy organ is the liver. And while we're talking a lot about the gut, and I agree that the gut is the main topic here, but how well your liver and your liver cells can turn that broccoli or that Skittles or whatever the heck you're eating into energy is going to be absolutely crucial. So metabolism is a function of your gut and your liver.

33:49Matt Titlow:So interesting. Okay, so let's go back to the gut. So again, if you're missing the exercise, the fiber and the butyrate, the receptors are being starved, basically, or your gut's being starved, so those receptors aren't telling your brain that you're full.

34:05unknown host:Right.

34:06Matt Titlow:So many women tell me that, like, I just never feel full, so I can keep eating and eating. So if not feeling full should be an indicator that your gut's off.

34:15unknown host:Exercise and eat some vegetables.

34:17Matt Titlow:Wow.

34:18unknown host:Yes.

34:19Matt Titlow:Okay. I'm going to tell them. So next time they tell me that they don't ever feel full, I'm going to tell them work on their gut health.

34:25unknown host:Yes. I would say it all just comes back to vegetables and exercise.

34:32Matt Titlow:Okay. So then now going to the liver, you've got to convert that food into fuel through the liver. Yes. I get this question a lot. People are like, okay, I understand that. But how in the world am I supposed to know if my liver is doing a great job or if it's sluggish or it needs help?

34:50unknown host:Triglycerides. So if you're going to your doctor and you said test, not guess, think of it as like a trash truck. and all this food is going in there, right? And now let's say it's not processing efficiently. Let's just say, and you had Dr. Ben Bickman on, and he was talking about insulin sensitivity, and insulin knocks on the cell's door, and if the cell isn't answering, we have an issue.

35:13Matt Titlow:Right. Okay, so the food goes through the gut,

35:15unknown host:and it goes through the portal vein, and it rides in the liver, and it knocks on the door, and it doesn't answer. Well, then it spills in the bloodstream. you don't want that because that's fat spilling into the bloodstream and other things and other things estrogen yeah you really don't want that yeah and that's why uh berberine got popular because of blood sugar insulin sensitivity chromium alpha lipoic acid green tea these are a lot of those blood sugar aids, insulin aids, let's call it. That really is the basis for this kind of gut liver metabolism issue.

35:58Matt Titlow:Okay. So back to the question of how do they know they're going to go get blood work and check their triglyceride levels.

36:04unknown host:They're going to check triglyceride levels.

36:05Matt Titlow:And if they're decent levels, then their liver's doing its job.

36:09unknown host:Yes.

36:09Matt Titlow:And if they're high, their liver needs some help.

36:12unknown host:Needs some help. You could also look at the typical or ALT, AST. Those are just liver enzymes. And those are very well tested at any doctor's office. And there are others. But those three are very easily and readily available, cheap, and tested all the time. Okay, so back to berberine versus GLP-1s.

36:38Matt Titlow:Yes. Some people take berberine. Some people do GLP-1s. They're sort of doing the same thing, not necessarily.

36:47unknown host:GLP-1s are expressing it for an extended period of time that no supplement can match. So yes, they are doing the same thing in terms of expressing GLP-1 or other satiety hormones, PYY. But one is doing it for a very long period of time and one is not. think of any food. When I eat, let's say broccoli again, any food, even sugar, it's going to stimulate my satiety hormones. Cause at some point you'll have enough fuel to where your body says, okay, I'm done. I'm full at some point. Right? So no matter what food we ingest, it'll express a satiety hormone, but what expresses it more? Well, maybe something like a berberine and maybe something like a GLP one drug, but the drug is dramatically different from a supplement.

37:37The issue with the drug is that you may just want a natural solution.

37:42unknown host:Maybe you are wanting to protect muscle. So you want to take berberine plus protein. It just depends on you. How do you feel about it, Karlyn?

37:51Matt Titlow:The GLP ones? Yeah, yeah.

37:53unknown host:GLP ones and the natural route. I would love, I would like to flip this.

37:57Matt Titlow:Well, I'm always go the natural route first, of course. I mean, that's what I teach. You know, I'm teaching eat the whole foods, quit eating so much sugar and processed stuff. I'm teaching lifestyle factors, get exercising, get sleeping, things like that. Me too. And I think a lot of times those things will help correct it so people don't need to do the GLP ones. Also, I'm a big believer in controlling your blood glucose levels, eating the carb with the protein, things like that. And so sometimes those will help it. But I want to say this little caveat. there is a time and a place for some people that it can be a great tool in the toolbox for me i've never there's one answer to anything i wish there was i wish there was one answer to depression and one answer to cancer and one answer to you know obesity things like that but there isn't so i'm really big about having a toolbox and that toolbox includes eating the real foods getting your gut in order you know watching your liver things like that the sleep the exercise all those things And if we need to include HRT for hormones, fine.

38:59Matt Titlow:If we need to include GLP for obesity and that's going to better their health, fine. But I'm never a go-to first to the drug. I'm a go-to first, the whole food and your lifestyle factors and things like that.

39:13unknown host:So well said. I want to pause on that. That was beautiful. And the reason why I say that was beautiful is twofold. One is I think that is the way we should go. The world is gray. Nature is a system and so are we. And the thing that I also like about it is a lack of judgment. Not judging each other for what works is just so needed right now. And so I appreciate if someone needs or wants a GLP-1 or wants to go the natural route, do it, right?

39:42Matt Titlow:Well, and for some obese people, it might be life-saving.

39:46unknown host:Exactly. But we're all different.

39:47Matt Titlow:And so work with your doctors, what I also say.

39:50unknown host:I love it.

39:50Matt Titlow:Well, thank you so much for being here and answering questions about trendy things like berberine, NAD, teaching us about core biome and the importance of butyrate. You have taught the followers a lot. I know that. So thank you so much for taking your time to be here. And we always end the podcast by asking five questions. And so I'm going to ask you these five. So first one, what emerging health topic excites you the most?

40:16unknown host:Okay, so this isn't necessarily emerging, but it will be. I love the gut, and I should say gut because that's where the consumer is right now. But the liver, that's next. So that excites me.

40:25Matt Titlow:This isn't one of the five questions, but what do you think is going to be the new trendy thing out there?

40:30unknown host:In terms of an ingredient?

40:32Matt Titlow:Uh-huh. Or supplements. Because berberine's a newer thing in the last few years. NAD's new and trendy in the last few years.

40:40unknown host:I think fiber will be the new protein. Yes. I believe the liver is next because we all want a, quote, fast metabolism. And we'll soon realize that metabolism really is a function of how well our liver is functioning.

40:55Matt Titlow:OK, love that. All right. Number two, what is a piece of advice you'd give to your younger self?

41:00unknown host:It'll all be OK.

41:02Matt Titlow:Oh, I love that. Oh, my gosh. I've been trying to tell myself that lately. Like, it's all going to work out. It's all going to be fine.

41:09unknown host:Yeah, the stress. Yeah, right. It's stress and intensity around that, the anxiety.

41:14Matt Titlow:That is true. Love that. Okay, number three, what's the one health practice you'll never compromise on no matter how busy life gets?

41:21unknown host:Oh, exercise, unequivocally exercise.

41:24Matt Titlow:Love it. I'm in the same court.

41:26unknown host:Yeah.

41:26Matt Titlow:Number four, what's your favorite Just Ingredients product and why?

41:31unknown host:Electrolytes, hands over fist electrolytes. You know, I love them. Taste because I believe in them and I take them every morning.

41:38Matt Titlow:Oh, I love that.

41:39unknown host:It's a ritual.

41:40Matt Titlow:Do you think everybody should take electrolytes?

41:43unknown host:Okay, this is me personally. Just opinion. I feel amazing sleeping, waking up. I didn't realize how dehydrated I was after that eight hours or whatever it is. I feel amazing waking up and taking your electrolytes.

41:56Matt Titlow:Do you know I don't take them in the morning? I need to. I wake up and have a protein shake and get to the gym.

42:02unknown host:Again, everyone can do what they like. I just happen to feel amazing on those first thing. I'm going to try that. Yeah.

42:08Matt Titlow:Do you like our ratio of potassium to sodium, a three to one?

42:12unknown host:Unequivocally, yes. I'm a huge fan. And here's why.

42:16Matt Titlow:Okay.

42:16unknown host:Because the average consumer isn't a marathoner or an Olympian. And we are the most deficient diet mineral in the American diet is potassium. And human history was more potassium than sodium in terms of actual food intake. And you've talked about whole food. I don't know how many times on this podcast. And I believe that more potassium than sodium is more whole food for the average consumer, me, than any of these sodium focused, which is more athlete focused electrolytes on the market.

42:50Matt Titlow:I love it.

42:51unknown host:I take yours because of your high potassium.

42:55Matt Titlow:Thank you. I formulated that myself because I was taking one that was too high in sodium. And for the same reason, I'm like, I'm not out running marathons. I have got to find one that the everyday mom, in my case, I was thinking the everyday mom can take and enjoy and sip on all day long and be fine. And well, two things. One, potassium helps get water into the cell. We need to hydrate the actual cells. So I'm like, why aren't people doing this? And two, I love that you said that with not even me telling you anything about what to say, because that is exactly what I pitched a main store. They were like, no, we've got too many electrolytes out here on the shelf.

43:33Matt Titlow:And I said, you don't have one single one for a non-marathon person. I'm like a stay-at-home mom. There's not one single one on yourself that I want to take. The buyer was like, wow, you've educated me.

43:45unknown host:That is my litmus test. I'm not even kidding for electrolytes because I'm not going to run a marathon. I'm not going to do that. I'm like, let's call it hybrid athlete guy. So I literally go, what is the potassium to sodium ratio? And then does it taste good?

43:58Matt Titlow:Well, awesome. I'm glad I asked you that. All right. Last question of the day. What is the best ingredient you've found to life?

44:04unknown host:Community, friends. I'm trying to work on that. I'm almost saying that to myself. I don't know how your husband feels about this, but I feel like as we get older, men tend to like go it alone and think, yeah, I can do this. I can do this myself. A defect in masculinity. And I find that, oh, it's about friends. It's about community. It's about connection. I think that's what is so magnetic about you and your audience is your ability to create that community and create the connection. And I think Just Ingredients exists because of how you have created a bond. And yeah, I think that's everything.

44:40Matt Titlow:Oh, you're nice. Well, thank you. And I think it's important for women as well. You said men,

44:43unknown host:but women need that community and friends and relationships just as much.

44:48Matt Titlow:So I love that so much. Thank you again for taking the time to be on the show.

44:53unknown host:Thank you.

44:55Matt Titlow:Thank you for being here and being part of this community. Don't forget to subscribe to the Just Ingredients podcast. We've got so much more to share with you. And if you're not already, come join us daily on all social media platforms at just.ingredients. Until next time, keep choosing what nourishes you.

From the publisher

In this episode, I’m joined by Matt Titlow, CEO of Compound Solutions, to break down what actually matters when it comes to supplements and gut health.

We talk about why absorption is just as important as what you’re taking, how your gut impacts everything from digestion to mental clarity, and what trends are worth paying attention to—and which ones need more context.

Bioavailability: What it means and why your body’s ability to absorb nutrients matters

Gut Health: Why your gut is often called the “second brain” and how it affects overall wellness

Butyrate: How this powerful compound supports the gut lining

Trending Supplements: NAD, berberine, and what to know before trying them

Practical Tips: Simple ways to support your gut with fiber, movement, and the right supplements

This episode is packed with helpful, easy-to-understand insight to help you make smarter choices for your health—without the overwhelm.

Bio:

Matt Titlow is CEO of Compound Solutions, an innovative ingredient house supplying

dietary supplement ingredients to the top brands in the industry since 1998. Matt earned

his MBA from Arizona State University and loves his Sun Devils, his alma mater Utah

Utes, and his son’s Oregon Ducks. He is passionate about health and wellbeing,

including whole foods and dietary supplement ingredients that help us be the best

version of ourselves.

Connect with Matthew Titlow:  

Website: https://compoundsolutions.com/

Matt’s LinkedIn: https://www.linkedin.com/in/matt-titlow/

Compound Solutions Instagram: https://www.instagram.com/compoundsolutions/

More about CoreBiome: https://compoundsolutions.com/what-is-butyrate-everything-you-need-to-know-about-this-powerful-postbiotic/

More about NAD3: https://compoundsolutions.com/ingredients/nad3/

More about butyrate: https://compoundsolutions.com/9-health-benefits-of-bioavailable-butyrate-for-your-mind-body-and-gut/

Exciting news! Just Ingredients is now available nationwide at Target — making it easier than ever to find your favorite products, in-store and online.

Looking for more Just Ingredients content? 

Instagram Stories: @just.ingredients

Podcast Instagram: @just.ingredients.podcast

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