In short
The episode explains chronic inflammatory response syndrome (SIRS) as chronic inflammation driven by immune imbalance, gut inflammation, neuroendocrine disruption, and mitochondrial dysfunction; then argues that peptides can be used alongside foundational lifestyle care (anti-inflammatory diet, sleep, stress reduction, gut support) to improve outcomes.
Guest background
Dr. Stuart Porter is a functional/integrative physician in Provo, Utah (Integrative Medical Associates) and co-runs Zage Medical Spa. He trained in conventional family medicine with obstetrics/C-sections, then shifted to functional medicine in 2009. He became interested in SIRS after a family boat became moldy, triggering severe headaches, visual issues, insomnia, and brain fog; he studied the Shoemaker Protocol and later adopted a peptide-integrated approach from Dr. Kent Holdorf.
Key claims
Peptides are “cell-to-cell” signaling molecules (short amino acid chains) that can be effective and well tolerated when properly sourced and dosed. Oral peptides can work, especially short “bioregulator” peptides with capped ends; GLP-1s can reduce inflammation via microdosing in selected patients. He says most peptide cycling isn’t necessary, and quality/purity is the main consumer risk.
Notable examples
Epitalin (telomere effects, circadian/pineal and thymus support; improved sleep in patients); BPC-157 (gut and tissue repair; warns about research-only store purity); KPV (used when melanocyte-stimulating hormone is low; linked to antibiotic-resistant staph in nose/sinuses); Thymogen Alpha-1 and TB4-FRAG (immunomodulation/repair); CJC with ipamorelin (growth hormone production/secretion, typically cycled).
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VODr. Stuart Porter's Background in Functional Medicine
0:45 to 4:28
Dr. Porter shares his personal journey and experience in functional medicine.
“And so I didn't want to do the research to tell you the truth.”
Understanding SIRS: Chronic Inflammatory Response Syndrome
4:28 to 7:22
Dr. Porter explains SIRS and how it relates to health issues like mold exposure.
“I know that because I know a lot of people go see you or at your clinic.”
The Domino Effect of Chronic Inflammation
7:22 to 10:36
Discussion on how chronic inflammation leads to various health problems.
“We were seeing people respond much faster, and our success race simply soared.”
Foundational Health: The Key to Recovery
10:36 to 12:46
Emphasis on the importance of foundational health in treating conditions like SIRS.
“And by doing that, our results are phenomenal.”
Introduction to Peptides: Basics and Benefits
12:46 to 14:00
Dr. Porter discusses what peptides are and their role in health optimization.
“Every person listening to this knows somebody on peptides of some sort.”
The Confusion Around Peptide Safety
14:00 to 14:54
Learn why there's mixed messaging about peptide safety in health discussions.
“That signaling will then get to the DNA and cause gene expression for those cells to produce whatever they're programmed to produce.”
Understanding GLP Peptides and Their Effects
14:54 to 15:38
Explore the differences in GLP peptides and their potential side effects.
“Like I said, there's a lot of different peptides.”
Microdosing and Inflammation Benefits
15:38 to 18:34
Discover how microdosing GLPs can help with inflammation beyond weight loss.
“So are there some concerns with some of them?”
Top Peptides for SIRs Treatment
22:22 to 24:12
Identify the five key peptides beneficial for treating SIRs.
“I'll start with epitalin, sometimes pronounced epitalin.”
Oral vs. Injected Peptides
24:12 to 28:00
Understand the differences in effectiveness between oral and injected peptides.
“A lot of my patients track their sleep and they can see their deep sleep and their REM sleep drastically improving, their sleep scores going up.”
Show all 26 chapters
Understanding Peptide Dosing
28:00 to 29:30
Learn about the different dosing schedules for peptides and the confusion surrounding them.
“Unless you want to dose it up 125 times what you would be injection, right?”
The Role of KPV in Hormonal Balance
29:30 to 32:00
Explore how KPV influences hormone levels and its applications in treatment.
“These are signals, molecules that as we age, we're producing fewer of.”
Growth Hormone Secretagogues Explained
32:00 to 34:30
Discover the function of CJC and ipamorlin in enhancing growth hormone production and secretion.
“So many of these, I plan on staying on long term.”
The Impact of Peptides on Muscle and Recovery
34:30 to 37:30
Understand how peptides like BPC-157 and TB4-FRAG aid in muscle recovery and repair.
“It has beneficial effects on recovery, on mitochondrial health, which is a huge deal.”
BPC-157: Benefits and Uses
37:30 to 40:20
Learn about the versatile applications of BPC-157 and its healing properties.
“So we only got through one of the peptides that you use, and I know there's at least five that you talk about in the book.”
Navigating the Peptide Market
40:20 to 42:00
Get insights on the safety and quality concerns surrounding peptide purchases online.
“This is healing, and because it's healing so well, it's reducing inflammation.”
Understanding Peptide Quality and Efficacy
42:00 to 44:30
Learn about the importance of third-party testing and how to identify quality peptides.
“They should be tested, third-party tested, ongoing.”
The Impact of Recent Peptide Regulation Changes
45:50 to 48:47
Explore the recent lifting of the peptide ban and its implications for availability.
“There were a lot of peptides banned, and just recently the government let that ban off on, I can't remember, is it 14 or 17 different peptides?”
Peptides for Health Conditions and Life Phases
48:47 to 53:58
Find out which peptides are recommended for various health conditions and life stages.
“In my practice, we have them in our medical spa on the shelf, and they do have the option of going to our website as well, for sure.”
Connecting Mitochondrial Function to Mood Disorders
53:58 to 56:02
Understand the relationship between mitochondrial health and mood disorders, including anxiety and depression.
“just with the addition of methylene blue.”
Weight Loss Peptides Insights
56:02 to 56:46
Explore the latest weight loss peptides and their effectiveness.
“The GOP3, the Red Trutide, or some like to pronounce it, Red Trutide.”
Mitochondrial Function and Mood Disorders
56:46 to 57:31
Learn how mitochondrial function relates to mood disorders.
“showed in his research that mood disorders are directly proportional to drumroll mitochondrial function.”
The Role of Peptides in Health
57:31 to 58:09
Understand the role of peptides as a tool in overall health.
“We need, you know, these correct nutrients.”
Future of Medicine and AI Integration
58:09 to 59:16
Discover the potential future impacts of AI in medicine.
“Well, thank you so much for answering so many of these questions.”
Peptide Resources and Book Announcement
59:16 to 1:00:26
Find resources for peptides and learn about an upcoming book.
“And so where can they find your peptides?”
Rapid-Fire Health Questions
1:00:26 to 1:01:51
Gain quick insights on health practices and favorite products.
“And it's not quite available yet, but soon coming.”
Transcript
Automatic transcript. May contain errors.0:00Welcome to the Just Ingredients podcast. I'm Cara Lynn, and here we dive deep into the journey of healing and wellness. If you're ready to learn, feel empowered, and take charge of your health, you're in the right place. Welcome back to the show. Today, I'm really excited for our guests because so many of you have asked me about peptides over and over every single day. It seems like hundreds of DMs about peptides, and people are just confused about peptides. But CERS has also become a trendy topic, and so many questions about CERS. So I brought an expert on who is an expert in both fields. And so welcome to the show, Dr.
0:41Porter. Happy to be here. Thanks so much. So Dr. Porter, like I said, is an expert on both of these. And so I didn't want to do the research to tell you the truth. There's so much research to do. I've done basic research on peptides, but I thought, let's just start bringing an expert. So I'm excited to delve into that topic with you. But before we begin, will you just tell my listeners a little bit about yourself and why you got interested or started in functional medicine? Absolutely. Happy to do that. But I first want to reach out and give kudos to you. My family and I have been fans for a very long time.
1:11Oh, thank you. You've done an amazing job at educating the public, bringing awareness to wellness and health. And so we thank you for that. Thank you. I really appreciate that. A little bit of background. I became interested in medicine probably just because of how I was raised. Middle of five boys, two younger sisters, trying to prove himself always as a middle child, unfortunately or fortunately, as the case may be. Our mother, bless her angel soul, was a pioneer in her own right in health and wellness and kind of pioneering natural ways of healing. She studied iridology, reflexology, homeopathy.
1:48Oh, she was a pioneer. You name it. And this was in 1970. So she was ridiculed by neighbors and friends and family. But because of that upbringing, that exposure, that piqued my interest in a more natural approach to medicine. Granted, we were kind of her lab rats in the home and sometimes her food experimentations weren't the best, I will say. But that did kind of form some of my thinking. I was interested in medicine at a very young age. I had an accident as a junior in high school where I cut my fingertips off. And there were a few members that said, oh, I guess you can't become a doctor now.
2:21You can't go to medical school. Unfortunately, I believed that for a while. I ended up attending Brigham Young University. I got an engineering degree. But toward the end of that degree, I realized that the injury to the fingertips didn't affect my functionality at all. So I decided to apply to medical school. I attended the original osteopathic medical school in Kirksville, Missouri. I'm dating myself, but graduated from Brigham Young University in 1984 and then graduated from Kirksville College of Osteopathic Medicine in 1988. Being competitive by nature, not to brag, but I just had to graduate first in my class, just kind of wired that way.
2:57Good for you. Well, I don't know. It's not a healthy way to be, but that's how I'm wired, right? After a residency in the military in 1995, because there's some payback time because the military pays for your education. I joined a conventional family practice group in Spanish for Southern Utah County, practiced full-spectrum family medicine with obstetrics and C-sections and enjoyed that. But along the way, I always felt inclined to try and practice medicine more naturally. I wanted to be able to help people, to empower them, to heal themselves. And as you very well know, conventional medicine, pharmaceuticals, so on and so forth, just doesn't really offer that.
3:37It's episodic sick care, really, that you're offering. And I didn't feel like I was truly helping my patients with that. So in 2009, I left that conventional group, started my own integrative functional medicine practice in Provo, Utah, Integrative Medical Associates, and have been doing that since then. I also brought with us Zage Medical Spa. We sell our supplements. We've kind of separated that from the conventional medicine, and we sell other things and do non-surgical cosmetic procedures and such. We brought that with us from Springville. I was in Spanish for work and then Springville 21 years ago now.
4:14So it's the longest standing medical spa in the county anyway. So anyway, that's kind of the background that led me to a desire to practice more holistic, functional type of medicine. Well, I love that. I love that you followed your passion and are helping a ton of people. I know that because I know a lot of people go see you or at your clinic. So thank you for everything that you do. So one of the things I want to talk about is a trendy word, I feel like, on social media, and that is SIRS. And I know you have written a book that will come out soon talking about SIRS, but, and you also talked though about how peptides can help SIRS.
4:53So before we delve into peptides, let's just talk about what SIRS is. Okay. If you don't mind, I'll also kind of give a background because, as you know, oftentimes it's personal experiences that lead us to research and study and then implementing those into our lives and our practices. But five or so years ago, we had, unfortunately, vinyl wrapped our family boat. It had trapped moisture in that boat. Didn't realize that when the following summer I took the vinyl wrapping off. And lo and behold, it was full of mold. And I spent the better part of the day cleaning out that mold with mold spores flying everywhere.
5:27I didn't really give it any thought then, but that really sent me into a tailspin. Up until that point, I was probably at the pinnacle of my health and fitness, being competitive by nature and rather obsessed on winning. I was involved in Ironman competitions on a world stage at that point. But that exposure to the mold sent me into a tailspin with my health. Interesting. Severe headaches, visual disturbances, insomnia, brain fog, which I'd never experienced before. it was pretty obvious to me that I was experiencing mold toxin illness. Now, another term for that is chronic inflammatory response syndrome, or SIRS.
6:04Up until that point, I had been a little reluctant to take the deep dive into SIRS because it's rather complex. That forced my hand. I then had a really good reason, personal reason, to take a much harder look at mold toxin illness, chronic inflammatory response syndrome. Learned all that I could. I did some certification training with the Shoemaker Protocol. He's kind of the original protocol, the doctor that pioneered a lot of the fascinating work in regards to SIRS. Learned after trying to implement that in my practice for a couple of years that it was complex, number one. Number two, difficult to follow for my patients.
6:45Number three, the clinical outcomes just weren't good. Yes, we had some successes, and those were wonderful. but the percent of success was disappointing. I then came across a book from a Dr. Kent Holdorf where he had learned to treat SIRS very differently, integrating peptides as part of those protocols, simplifying the process of diagnosis and treatment, and accelerating the results with much better results. I started to implement those protocols, and I've tried to simplify them and fine-tuned them since then, and I put some of that information in my upcoming book, but very satisfying results.
7:28We were seeing people respond much faster, and our success race simply soared. Interesting. So to go back to what you're asking, what is chronic inflammatory response syndrome? I now define that and view that differently. Previously, because of Dr. Shoemaker's experience equating exposure to biotoxins, mold in particular, and water-damaged buildings, it was then called mold toxin illness because that was the trigger that started the inflammatory cascade and all these subsequent imbalances that cause all these health problems, chronic health problems. Since then, I tend to view it differently. Most everything in regards to chronic conditions is from chronic inflammation.
8:12So rather than using this rather strict diagnostic criteria for chronic inflammatory response syndrome, I now like to view it as just chronic inflammation. So it's a larger umbrella. You know, you think about people that come in to see us for health concerns. If 25 % of the population approximately has genetic predisposition for SIRS, and you can test that with certain genetic testing if you're interested, I no longer find that necessary. But I estimate that the patients that walk through my door to seek help for their conditions is probably eight out of 10 people. So very, very common. Chronic inflammatory conditions are extremely common.
8:50The domino effect, in my opinion, I like to try and simplify it. The upstream problem is this genetic propensity to have immune imbalance. Immune imbalance and inflammation kind of go hand in hand. And immune imbalance and gut inflammation that you're very familiar with also tend to go hand in hand. So the upstream problem is really this propensity for the immune system under various insults to go out of balance. That's commonly associated with gut inflammation, and 70 % of our immune cells surround the gut lining, so there's that very strong interconnection between gut and immune function. That imbalance and gut inflammation allows dominoes to start to fall.
9:32We then see neuroendocrine disruption. That can be sex hormones, other hormones, antidiuretic hormone. It's a hormone that signals from the pituitary to the kidneys to hold on to water properly. So people who aren't producing that hormone will urinate frequently and have excessive thirst and they're chronically dehydrated and they have POTS symptoms and the list goes on, right? There's more neuroendocrine disruption, dysregulation, and downstream from that, we see mitochondrial dysfunction. Probably in many cases, the last domino that falls, perhaps. Some would argue that, chicken or egg. But once the mitochondria start to underproduce ATP, that energy currency, when they're dysfunctional, things go from bad to worse.
10:15Because then we can't recharge the cellular batteries to tell the cells, the individual cells, to do their various different jobs. It just puts us in a very bad place. So chronic inflammatory conditions then become worse. Then there's fatigue. Then there's brain fog. And we're in a bad place, right? Yeah. So we need interventions along various different angles, addressing all of those dominoes that have fallen. And by doing that, our results are phenomenal. Yes, it's complex, and it's not easy to accomplish. It takes a big commitment to consider following some of these protocols. And I'll just throw in there, I'm sure you're going to ask this down the road anyway, but we cannot skip foundational health.
10:57We have to focus on foundational things. The peptide integration is kind of the icing on the cake, right? We have to make sure we're doing the foundational things, that we're following an anti-inflammatory diet, that we're getting appropriate restorative sleep, that we're managing our stress and not letting ourselves get stuck in this fight-and-flight reflux and not having enough parasympathetic tone, that restorative side of the autonomic nervous system. There's a lot of pieces to it. And then come the supplements, the omega-3s and the prebiotics and probiotics, and in some cases, curcumin. There's so many other pieces to it, but we cannot skip the foundational items.
11:36Okay. So I'm going to do a little recap. So SIRS is basically chronic inflammation, which so many of us are dealing with. And what has happened though, is that they're dealing with brain fog or fatigue, which then they go to the doctor for that and they find out they have a mold exposure or some other maybe virus or something going on, which then is causing some hormonal issue. And so it's this huge cascade of different health issues that we're just putting under an umbrella called SIRS. Right. Okay. So the Dr. Shoemaker protocol was really focusing on taking binders to bind these toxins because he viewed those as the main culprit.
12:14My current approach is that's kind of a downstream problem. So let's focus on balancing the immune system, reducing the inflammation, correcting the immune system so that we can process those biotoxins properly. So it's just a different viewpoint, but we're having better success rates. Okay, so first step is they're going to have a foundational health basics, like you said, of anti-inflammatory diet, which a lot of people don't do, the sleep, the stress, things like that. But then what I want to delve into with you are the peptides. Right. Because a lot of doctors out there don't do peptides. for SIRS.
12:49Peptides are trendy. Every person listening to this knows somebody on peptides of some sort. And so let's delve into peptides, but let's start at the very basics. Because the other day I asked someone, what is a peptide? Just a friend of mine. And she's like, well, it's this stuff that you inject that's really trendy right now that can help with things. And I was like, well, I know, but what is a peptide? And she couldn't answer. So I was like, okay, let's start at the basics for everybody. So what actually is a peptide? A peptide officially is a short amino acid chain. There are different types of peptides.
13:21Some of the very short amino acid chains are sometimes called bioregulators, but they're essentially signaling molecules. They're how our cells communicate between each other. Think of it as a text message, cell to cell. I like the term whisper because they are different than hormones and proteins in many aspects. Therapeutic peptides whisper cell to cell, turn on this pathway, turn off that pathway, accelerate healing here, put the brakes on inflammation here. They're sending different signals. As hormones work, these peptides find the receptor on the outside of the cell. They attach to the receptor, and that sends further intracellular signaling.
14:04That signaling will then get to the DNA and cause gene expression for those cells to produce whatever they're programmed to produce. But they're fascinating molecules. There's over 7 ,000 of them in our body known, and we're discovering more all the time. But they're safe and they're effective. I hesitate using that term because we heard that about the COVID vaccine, which is not safe and effective by any means. But let me at least flip that around. They're very effective and very safe. Okay, well, let me ask you that because being in the health world myself, you've got people in the health world saying, use them.
14:39They're amazing. They're so effective. They're life-changing. And you have others saying, absolutely not. They are dangerous. They're not good for you. They're messing with your body on X, Y, and Z. So why are we hearing both sides like that then? Because it confuses the consumer. It's very confusing, and there's a lot to sift through, right? Like I said, there's a lot of different peptides. And it takes the right viewpoint to try and see how they can be integrated into our health optimization protocols. It isn't simple. I think some of the naysayers are, you know, I've seen this in conventional medicine.
15:13I'm what they would call an early adopter, many are not. And so the late adopters or the medium adopters are the ones that are a little bit more hesitant. You know, some of these are not yet fully FDA approved. So there's some confusion in that regard. but I've been using them in my practice for years now, and I'm very, very convinced of their efficacy and their safety profiles. So are there some concerns with some of them? Perhaps, for example, the also popular GLPs can be overused, and some are better than others. So there's a lot of confusion there, right? A lot of people get so anxious, and it's not all their fault.
15:53I think they're being guided incorrectly, but let's just use GLP-1, GLP-2, semaglutide, trisepatide, ozempic, manjaro. Use those as examples. At the common doses that are being prescribed for weight loss, the side effects are kind of nasty. There's nausea, there's hair loss, there's muscle loss. It can be problematic, but when used judiciously in the right patient, in the right manner with microdosing, a lot of those potential problems can be circumvented. Yeah, there's nuances to it, so it can be confusing. Okay, so I think it's the side effects maybe that people are touting as bad out there.
16:30Like all these peptides have side effects, like you just said, if it's dose-strong. So do all peptides have side effects like GLP-1 or no? They do not. Okay. Most of the peptides that I'm using, I do use some GLPs sometimes in my treatment of chronic inflammation. but these oral peptides that we use a lot of in our SIRS treatment protocols are extremely clean, extremely beneficial. Side effects are just not seen. They're just really, really well tolerated. Interesting. Okay. So I want to talk to you about orally versus injected, I should say, but I'm going to come back to that in just a minute.
17:11I'm going to go back to Gio. I tend to get heated when I answer that question. Well, I have about 7 ,000 questions to ask you. So we're going to pick which ones we can ask. But let's go back to GLP-1s. I actually wasn't going to touch upon this in this episode, but you brought it up. I'm sorry. No, no. It's great because I know a lot of women are taking it. But you said you use it as a protocol for inflammation. Well, a lot of Americans are dealing with inflammation. So how does it help inflammation and not just weight loss? Great question. There's a few different pathways that help with inflammation.
17:46I think one of the ways that it probably helps is our fat cells, especially if we're carrying extra fat, tend to hold on to toxins. So just the mere fact that we're shrinking those fat cells through the weight loss process with appetite reduction and so on is going to help to reduce inflammation. But there are other anti-inflammatory pathways that are affected by these and other peptides. And when we microdose, that's commonly our main purpose. I have a lot of patients microdosing that don't need weight loss. And these microdoses, when used judiciously, right dosing, it's not going to cause weight loss.
18:28But I do see some benefits many times in reducing general systemic inflammation. Some of the blood markers that I commonly follow will be positively affected on microdoses of GLPs. Interesting. Okay, so what is considered microdosing, though? Because that's a mess out on social media also. I don't know if you know that, but like on TikTok, one girl's like, I'm microdosing, and another girl's like, oh, that's not considered microdosing. That's way too much. It's rather vague. So unfortunately, we don't have clean definitions on what microdosing is. But I'll give you one example. I'm currently experimenting with a research-only peptide calling a GLP-3 retitrutide or retatrutide.
19:12And it's like terzepatide, but a step up. It's generation three. The results that they're seeing on that is nothing but amazing. I'm microdosing what might be called an anti-inflammatory, anti-aging dose, 200 micrograms. My 24 milligram of oil is going to last me two years. Oh, wow. That's microdosing, right? Yeah. and no noticeable side effects. I'm not positive yet because I haven't repeated blood work. If it's doing me any good, is it giving me benefit? I don't know yet, but at those doses, I've done enough research, I feel comfortable about the safety profile, so I'm going to experiment with that.
19:46So that's just one example. That's ultra-microdosing. There's hepatite, for example. When it comes in auto-inject pens in the form of Manjaro, it was a pound from the pharmacy, not compounded. you can only get what you have in that autoinject pen. And those come from 2.5 milligrams up to 15 milligrams strength. We start people off at a fourth of a 2.5 milligram. Oh, wow. And it's very, very, very little. Very little. With the intent of probably getting them up to 2 to maybe 4 milligrams. The highest dose for weight loss is 15. So that's pretty low dose, right? That is low. And that's for weight loss.
20:28That's not just for inflammation. It would be even lower. We just find you don't need as much as the pharmaceutical companies want you to believe that you need. Interesting. Well, there's a lot of people online saying it's terrible for the gut, these GLP-1s, because we're not moving the food through the digestive tract as fast as we should. So when you're microdosing that small, is that not a side effect? The poison is in the dose, as with most medications. So it can still be a side effect, but it's manageable, right? It does slow down gastric emptying, which is part of the reason why there's a reduction in appetite.
21:04It can contribute to heartburn because of that reason. There are ways that we can manage that. Yes, those are side effects. Does it cause problems with gut function? Not so much. At high doses, yeah, you can have peristalsis. That's an awful side effect. It's reversible, by the way. But I actually see a reduction in gut inflammatory markers with appropriate judicious use of GLPs. Let's take a quick break to hear from our show sponsor. When you hear the word peptides, it can sound intimidating. But as you're hearing from Dr. Porter today, the right peptides are simply powerful messengers that support energy, deep sleep, recovery, and healthy aging from the inside out.
21:52Haven Peptides was created to do exactly that, with high-quality, clinician-backed formulations designed to work with your body, not against it. Instead of ineffective shortcuts, Haven focuses on root cause support for fatigue, brain fog, stubborn weight, hormone changes, and stress resilience. If you're curious about this conversation, head to havenwellness.com to learn more and find the right formula for you. Now back to the show. So I want to move on, though, because you have five peptides you really like for those that are dealing with SIRs. Is that correct? And more coming. And more. We have five, yes.
22:30Okay, so let's walk through those five. Can we start with the first one? What is it? Would that be my favorite? It probably is. Okay, okay. I'll start with epitalin, sometimes pronounced epitalin. It's my favorite for a couple reasons. Rather unique, it affects telomeres. Telomeres, as you know, are what affect our rate of aging. and these lengthened telomeres or at the very least slow the shortening of telomeres. To give you an idea of how profound this can be, a study by Dr. Cavinson, a Russian scientist that researched these starting in the 1950s, this has been around a long time, right? He studied a group of 80-year-old Russian coal miners, retired, probably smokers, very unhealthy population, a six-year study.
23:15Over the six years, 80 % of the control group that did not take that epitalin died. The group that took the epitalin shy of 20 % died. They were 4.1 times less likely to die over that six-year time frame, and they only took this epitalin peptide two weeks every six months. Oh, interesting. So profound effects on longevity and anti-aging. It also affects the pineal gland. The pineal gland controls circadian rhythms, biologic clock. It also controls the thymus gland. the pineal gland and the thymus gland start to involute, shrink, calcify, not work properly starting as early as age 30. And this medication helps resurrect that function.
23:59Of all the peptides, the oral peptides that we use in these treatment protocols, that's the one I think is the most noticeable because people whose baseline sleep isn't great will feel that restorative sleep returning. A lot of my patients track their sleep and they can see their deep sleep and their REM sleep drastically improving, their sleep scores going up. It's phenomenal. I mean, just from the mere fact of what it can do with slowing aging, let alone whether or not it helps with sleep, and it usually does, who wouldn't want to do that? Who wouldn't want to take that? At least two weeks every six months just for the anti-aging benefit.
24:35Okay, so let me ask you about this. If it's affecting the telomeres and it's a longevity thing, are we saying it can help with skin appearance also and joints and all the things that come along with aging? All those things. It's also, interestingly, a growth hormone secretagogue. A lot of people go to extreme efforts, and I commonly will prescribe those growth hormone secretagogue injections, CJC with epimoralin, tesamoralin with epimoralin, sermoralin with epimoralin, and others. This one actually helps growth hormone production without having to inject. And it has anti-inflammatory benefits, immune-moduling benefits.
25:09The list is very long, probably through that primary mechanism of slowing down telomere shortening. Okay. So let's talk about this injection versus orally, because I know a lot of people that do CJC with injections. And again, on social media, you hear people say, don't ever take peptides orally. They won't make it through the digestive tract. That's a bunch of baloney. You have to inject them. So explain that to me. Thank you for bringing that up, because I think there's a really big misunderstanding when it comes to oral peptides. In reality, most all the peptides can work orally. But I'll give you an example.
Read the full transcript
25:46Somaglutide is now available orally. Okay. The dosing, the oral dosing for that long or more complicated peptide, 125 times what it would be via injection. So the longer peptides are not very bioavailable orally. Can they work? They can work, but they don't work well orally. However, bioregulator peptides, short peptides, which officially defined as 4-amino acid in length or shorter, work very well orally if they're processed and produced properly. They have to be produced properly in the right kind of lab. The ends of these molecules have to be capped, acetylated or amylated capped ends, which not only protect them from degradation and digestion like you just asked about, but they also mimic how they are in nature.
26:39So they're going to have much better effectiveness, much better bioavailability. But simply put, those short amino acid chains work orally, in my opinion, equally well when they're properly produced and tarot coated so they're not being exposed to acid directly in the stomach. Now, the exception to that is the popular BPC-157, the so-called wolverine peptide. It's 15 amino acids in length. So in theory, it would probably more likely be digested, broken down, and not be able to send the signals that it sends. However, BPC-157 is naturally produced in gastric juice in the stomach. So the body doesn't see it as something foreign when ingested supplementally orally.
27:26Interesting. It still works orally. Now, there's an argument, and I can't argue this one. If you were to inject BPC-157, which until very recently was still banned for injection, if you were to inject that into a tennis elbow, it's going to work faster via injection than it will orally. Okay. The oral is going to work. Makes sense. It's going to take longer, right? So many of the peptides, the ones that we currently have with our brand, for example, are bioregulators. They work orally very, very well. Okay. So basically, if it's a short chain, four or less, and they're coded correctly, basically, they're great for oral.
28:03Yep. Otherwise, except the BPC-157. Otherwise, they're best injected. Unless you want to dose it up 125 times what you would be injection, right? Okay. Yes. Okay. But what also gets confusing out there is every peptide has to be dosed differently, doesn't it? Like some you can take daily. Some are only five times a week. Some are six times a week. How do people know what is what? Well, hopefully they're seeing a medical professional that has some training in that and can guide them. Some aren't. They're getting them off of any market they can find. Absolutely correct. Which we'll get back to that because I want to ask you about that as well.
28:42Yeah. The other thing that I'll bring up is there's not good evidence for most of these peptides that you necessarily need to cycle off. Interesting. That's not what a lot of people would say. Keep in mind, and I don't want to offend any particular group of people, but a lot of the information from peptides comes from the bodybuilding world. Okay. Makes sense. I'm grateful for that. It came before we knew any of these worked orally, these shorter bioregulators. It also comes from the mindset, you know, when they're using high-dose anabolic steroids, they cycle on, they cycle off, they cycle on, they cycle off.
29:18So it was kind of in their regimens to cycle on and off. But I'm not yet convinced, and there are some I believe that you should consider cycling off, but I'm not convinced that you have to cycle off these necessarily. I'm not. These are signals, molecules that as we age, we're producing fewer of. When the mitochondria aren't working optimally, which is part of aging, we're not making as many of these signaling molecules as we once were. So we're augmenting what we should be producing. We're not necessarily causing us to produce fewer. We were already producing fewer. So why would we necessarily have to cycle off all of these?
29:56It doesn't make sense to me. And I'm not yet convinced from the current science that we need to consider cycling off, cycling on. I'll give you one example. There's a peptide called KPV. It's a tripeptide, fabulous peptide, meaning it's three amino acids in length. It's the terminal fragment of a hormone that many of us aren't familiar with called alpha melanocyte stimulating hormone, a very important pituitary regulatory hormone that influences inflammation, immune balance, healing, and has antimicrobial properties. It's anti-candida, it's anti-staph, antibacterial. KPV is a terminal fragment of that hormone.
30:30So it's sending the signals that we're not sending when we're underproducing those hormones. that hormone, which is very common in people with chronic inflammation. So with KPV, when we're treating it for those with low melanocyte-stimulating hormone, there's a high likelihood, believe it or not, that they have a particular staph overgrowth in the nose and sinuses when their melanocyte-stimulating hormone is low. This is all part of the Shoemaker protocol for treating SIRS. And we can actually culture them and prove that they have this Marcon staph, multiple antibiotic-resistant coagulation negative staph.
31:03In order to restore melanocyte-stimulating hormone properly, it requires taking KPV twice a day, or almost using it as a natural antibiotic, for four months or longer. You know, most people are suggesting cycling in shorter intervals than that. So that's just one example of why, in my protocols, I'm going to suggest using that longer and not considering cycling off. If you cycle off before we can prove with blood tests that we've restored proper levels of that melanocyte, seemingly hormone, it's going to fail. And you will have wasted time and effort and money in taking that peptide for a shorter length of time.
31:38That's just one example. Interesting. So for the most part, you think if they're taking these orally, they can just take them daily like a supplement? Personally, I don't plan. I'm 67 years old. I don't plan on stopping BPC-157. I probably will cycle off and on the epitalin. I'm still on KPV because my melanocyte stimulating hormone hasn't returned to normal still. I need to check it. It's been a while. So many of these, I plan on staying on long term. Okay. Every day. That's just me. That's just me. That's not for everyone necessarily, but it's not necessarily a bad thing or unsafe. Well, it's so interesting because the other day someone gave me a chart of all these different peptides and literally everyone had a different dosing one.
32:20It was this one five days, two days off at night only. This one, six days, one day off, and morning only. This one, daily. This one, and I was like, wow, how can anybody even keep track of all of this? There are some. For example, the growth hormone secretagogues, such as CJC 1295 with epimoralin, those should be cycled off. And there's good reason for that because you don't want to get used to the same input. This is causing other hormone secretion, right? Okay, let's talk about CJC because that is a popular one right now. So what is CJC and what's it doing? And why is this one a trendy one that people are on?
32:56Yeah. It is a growth hormone secretagogue. There's kind of two facets to optimizing growth hormone production and secretion. One increases production. The other improves secretion. Producing is one thing. Then we need to, in a pulsatile fashion, secrete it in the bloodstream, right? Okay. So in this case, the CJC helps us produce more. Okay. And the ipamorlin helps it secrete in a pulsatile fashion to mimic what we should be doing, right? Okay. And those, yeah, the growth hormone secretagogues, it makes sense. Typically five out of seven days, Monday through Friday, off weekends. And once you've used it for a few months, either cycle off or cycle to something a bit different.
33:36And some of these strategies, we want to keep the body guessing a little bit. Okay. But it's not documented with, I guess my point is, it's not documented with every single peptide that you have to cycle on, cycle off. Okay, but some are. But CJC, let's go back to why it's trendy. Is it because it's helping people build muscle? Is that the number one reason for it? Growth hormone does a lot of things. As we age, we tend to produce less and less growth hormone. We measure that with a blood level called IGF-1, insulin-like growth factor type 1. You know, in our youth, in our early 20s, our teens, levels are high.
34:09As we age, those start to dwindle. And with chronic inflammation, they dwindle even at younger ages. We can measure those levels and we can determine if someone needs or wants to consider optimizing growth hormone secretion, production and secretion, right? So growth hormone does a lot more than just build muscle. It is kind of considered the fountain of youth hormone, right? It's helping repair. It does have some anabolic building effect. It has beneficial effects on recovery, on mitochondrial health, which is a huge deal. So there's really quite a few different facets of benefits from boosting growth hormone production.
34:44Now, once upon a time, because of a single study, I was sometimes prescribing growth hormone itself. I don't like it any longer. It has particular risks and downsides. It can cause swelling. It can push us toward insulin resistance. We don't want that. So I no longer advocate growth hormone production because even into our 90s, we have the machinery to produce our own optimally. It just needs some input, some encouragement to get there. So CJC then is also considered a longevity peptide. Sure it is. So there's multiple longevity peptides out there. Right. Just different types. Right. Different types.
35:22Exactly. Okay. So is CJC one that you use in your inflammation protocols or not necessarily? Sometimes. If their IGF-1 levels are low, that certainly is part of our discussion. Whether or not the patient wants to spend the money and go to the trouble self-injecting five out of seven nights, that's a personal decision. But it's certainly on the table for discussion. If someone wants to build muscle, is that the one you recommend for them? Or would you recommend a different peptide? We also want to make sure that we're optimizing their anabolic steroids, testosterone, particularly want to make sure we're optimizing that.
35:56That's a whole other discussion, right? I'm a fan of optimizing our endogenous production and doing all I can to avoid having to borrow it. Because it's much more complicated, much more likelihood of side effects if we're borrowing it rather than optimizing our own production. So someone that is wanting to have help increasing their muscle mass, you look at their testosterone first, then a peptide. Testosterone, growth hormone, there are other peptides that are very helpful for recovery and repair. BPC-157, TB4-FRAG, which is the oral equivalent of TB500, those work synergistically. They're very good for repair and recovery.
36:37Epitalin, with that restorative sleep component, that's an incredible recovery stack. And yes, if they also need growth hormone support, then there's that component as well. By the way, when we optimize growth hormone, that alone helps with our restorative sleep. Okay, so you just stacked a lot together. And I'm curious, is there a point when you're stacking too many together? Because I actually know someone who took an ER visit recently, and they were told it was he took way too many peptides altogether. Yeah. Unfortunately, I think you can get carried away. You know, there needs to be a good reason for what you're doing.
37:12And I do have some patients who do some things on their own without necessarily our guidance. And yeah, I think it can get a little overcomplicated. I'm not sure what may have happened in this particular individual's case, but in general, it's pretty safe to stack these peptides. There may be some exceptions to that, but it's pretty darn safe. Okay, so let's go back to SIRS. Yes. So we only got through one of the peptides that you use, and I know there's at least five that you talk about in the book. What's the second one? So I'm testing blood levels. There's one test that we commonly get called transforming growth factor beta 1, which represents maybe the degree of inflammation associated with the degree of immune imbalance.
37:55So for that particular entity, depending on how high the level is, I may recommend, in addition to low-dose naltrexone, which you're probably familiar with, which allows us to produce more endorphins, which in and of itself is immunomodulating. That's not a peptide. It's a prescription medication. But I'll also recommend Thymogen Alpha-1 that has some other names to it. It's two different dipeptides together, a thymus gland-related peptide that's very immunomodulating. It raises the underactive side. It calms the overactive side. TB4 Frag, which I just mentioned as part of the repair and restore stack, is also immunomodulating.
38:31It raises the underactive side. So depending on that level, that bloodline, I may be recommending three things for that particular category of inflammation. and immune imbalance. I mentioned this one already, but if their melanocyte-steamulating hormone is low, I'll recommend the KPV peptide for a good length of time. I'm measuring gut inflammatory markers. I'm also oftentimes measuring a test to give me an idea of the degree of gut leakiness. Inflammation is one thing, leakiness is perhaps another. And the BPC-157, especially orally, is phenomenal to facilitate healing the gut. But I don't want to skip the foundational things.
39:09They need prebiotic vegetable fibers. They need probiotics, including spore-based probiotics, postbiotics, which by the way, I love your probiotic complex because it includes postbiotics in it, which is awesome, right? So they need those other foundational support items, not just the peptides. Okay. So let's talk about BPC-157, just because I know I have a lot of friends that take it. Is it best for gut healing? Is that what they're taking it for or are they taking it for other things as well? Probably other things. I mean, yes, it's very good for gut healing. What's it common for? Why are they so many taking this?
39:47Well, it repairs. It encourages repair throughout the body. Gut lining, joints, ligaments, tendons, heart, brain. With that repair encouragement, I guess you'd say, because these are whispers, right? You're also increasing angiogenesis, meaning improved blood vessel production to the areas in need. So yeah, it can be used for a variety of things. There's a very long list of benefits from the BPC-157 peptide. It's not just healing and inflammation. Consider comparing that to something like ibuprofen. Reduces inflammation, but completely blocks healing. This is healing, and because it's healing so well, it's reducing inflammation.
40:27What would you choose? Okay. So if BPC-157 is so healing, why can't we buy it on a store shelf? Why can't everybody just take it? Great question. It's one of the ones that recently the ban is being lifted. Fortunately, at least for the time being, and maybe the Noy Smiths podcast will change this, hopefully not, but oral peptides are, for the most part, being left alone because of the safety profile. The concern with some of these research-only peptides, which is the only way you could get BPC-157, hopefully that'll change very soon, we can't trust all those online research-only peptide stores.
41:05They've been analyzed. Some of them have higher amounts of what are called lipopolysaccharides, LPSs, which can also stand for little pieces of stool. It's not cool. So there's purity problems, safety problems with some of these injectables because of the hands they've been in. Now, are some more reputable than others? Yes, yes. But it's a little risky, Right. And we hope that's changing in the very, very near future. But the oral ones, safety profiles better, in my opinion, because you're not injecting who knows what. Yeah, for the most part, hands off as far as as far as regulations. Well, I know with BPC-157, you don't have to have a doctor's prescription.
41:46Correct. You can buy them online and lots of different places. I had a friend just buy it from China recently. And so how do you know what you can trust or not? You really need to do your research. they should be third-party tested, and not just once and not just in one location, right? They should be tested, third-party tested, ongoing. And if they're not, and you can't verify that, then they're very hard to trust. Most of the peptides, for example, we'll use BPC-157 that you find on Amazon, are not even peptides. These peptides, it's a process. These peptides have to be grown. Yes, you start with amino acids as the building block.
42:20They have to be linked. They have to be grown in the right order, in the right fashion. And then they have to be capped with the right kinds of molecules on the end of them, then they have to be encapsulated in the right kind of capsule. There's just a lot to it, right? It's not a simple process. But because there's a lot of hype, a lot of noise, a lot of the stuff that is out there is not quality, not good quality. So that makes it hard for the consumer to know really which one they should get. If it's working, you'll feel it. And BPC-157, usually within a week or two, sometimes longer, you'll start to hurt less.
42:51I mean, I can't tell you how many men on our oral BPC-157, once they've been taking that for a period of time, their shoulders no longer hurt like they did. You can feel it. The epitalin, you can feel it. You're sleeping deeper. You're sleeping better. Yeah, you can feel it if they're working. Now, some take longer than others. Some of them aren't as noticeable as others, but they do work because we can monitor those blood markers and see that they're doing what they should be doing. So if someone's listening to this show who doesn't have a doctor that they're working with, would you be afraid if they took epitalin and BPC-157 tomorrow, start just taking tomorrow?
43:23I would not. And I would suggest BPC, sorry, I probably suggest Epitalin as test number one because you're going to notice it sooner and faster. And it's a great way to kind of warm up optimizing your health. Many of us aren't getting that restorative sleep that's so critical. So Epitalin, absolutely. BPC-157, no problem. And I mean... You know, a lot of doctors don't say this. Correct. A lot of doctors are like, wow, he is just saying this on air right now. I'm old enough. I don't care like I once did as far as ridicule or whatever consequences might happen from this. So not trying to be nonchalant about that.
44:00But the results I'm seeing in these protocols is so incredible. It's worth the risk to put this out there. So do you think we'll get to the day and age where BPC-157 will just be on a store shelf and that's what people will take for pain? Good question. I hope so. I could see years down the road. We have dangerous drugs over the counter. I know. Non-steroidal anti-inflammatory medications, proton pump inhibitors, those are horrible medications, and they're over the counter. So why not? Yeah. Let's take a quick break to hear from our show sponsor. This podcast is sponsored by Active Skin Repair, a skin health brand that helps your skin heal using natural, non-toxic, medical-grade ingredients.
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46:01Somewhere around there. In the mid-teens. I don't remember the exact number. And so why was there a ban, and now why is this ban lifted? I think the why is kudos to RFK Jr. and his team, right? There's so much need for these peptides. I think it's that government body that's helping force that because, you know, a lot of pharmaceutical companies are hoping that they can patent this and make their billions and trillions off this, that, and the other. And so I thank that government body for pushing the issue to have the ban lifted, right? And so the ban lifted means what? It means they're going to make it available so it can be in the hands of licensed compounding pharmacies.
46:39Because where are compounding pharmacies getting it currently? Well, compounding pharmacies are not offering the banned peptides. Where people are buying them is from research-only online peptide stores, which aren't necessarily— So maybe these compounding pharmacies are buying it from those places and giving them out? If you find a licensed compounding pharmacy that's selling a banned item, they're in trouble. They're in trouble. All right. Well. Or they're taking a big risk and hoping they don't get caught. Okay. I'll keep my mouth quiet then. Yeah. Okay. So let's review then for SIRS. For SIRS then, the five peptides that are your first go-tos are what?
47:19Thymogen alpha-1, TB4-FRAG, KPV, and BPC-157. The one that's not necessarily part of the protocol for SIRS is epitalin because that falls under the discussion of sleep optimization. I don't know that I can think of SERS patients that are actively having symptoms that are getting that quality restorative sleep. So that would be another that would very likely be part of that protocol. So all five of those, do you sell all five of those? We do, yes. And are they all oral ones? They are all oral, yeah. Okay. And like you said earlier, oral is just like injectable ones, meaning you've got to find a good source of them.
48:02And you have gone to lengths to make sure it's a good source. Absolutely. There are probably only four or five different brands on the market that are fairly trustworthy. What you find on Amazon is very likely not even a peptide. And that goes with a lot of their supplements. Just FYI, a lot of their supplements are unbelievably not what they say they are. Amen. Yeah. So yeah, you have to trust that they're properly sourced, properly processed, that they're grown in the right kind of lab, that the ends are capped and tear-coated capsules. But more importantly, you want to make sure that they're third-party tested.
48:37Otherwise, you just don't know whether to trust them or not. So I think that's a critical, critical piece when you're shopping because peptides, the quality peptides are not cheap. So are people just coming to your website to buy these? In my practice, we have them in our medical spa on the shelf, and they do have the option of going to our website as well, for sure. Okay, so I'm curious, what is your number one top-selling peptide? BPC-157 is outselling the others. The others combined are equal to the BPC-157 currently. Oh, interesting. I would like to see more of the Epitalin used because it does so many fabulous things.
49:14nothing against BPC-157. It's incredible. But the epitalan is my favorite. Do you feel like there's an age limit of when people should start peptides? Because I'm going to get people saying like, oh, can my 16-year-old take peptides? Can my 18-year-old? What's the age? Great question. I would suggest consulting a medical professional, especially in the pediatric population. That said, I'm very comfortable with the safety profile of these. I can give you one example. I have a couple. They both have chronic inflammation. They're both on our SERS peptide protocol doing well. Their five-year-old was really struggling with sleep.
49:52And without consulting me, fine, I'm not angry, they gave him the epitalin, one at bedtime, same dose they were taking. Keep in mind, these aren't drugs. These are whispers. They're molecular whispers, so they're different. I like that analogy of them. This five-year-old responded dramatically, and I don't remember off the top of my head whether he took that for two weeks or four weeks, but he has continued to sleep well since that reset. Interesting. You wouldn't think that a pineal gland is going bad in a five-year-old. Right. But it reset. He responded beautifully. And again, I would consult medical professionals before considering that.
50:33But understanding myself, its safety profile, being old and a little callous as to the repercussions that could happen, And yeah, in the right situation, I could support that. Okay. I am so curious because I have so many people reaching out about peptides. I'm curious if we can just go through a list of health conditions out there or health phases in life. And you say which peptide would help the most. Okay. Can we do that? Let's go. Okay. Perimenopause. Epitalin. And here's why. In fact, I have one example of that. A patient of mine, I see their whole family, right? and they live in the Evanston area.
51:10Her sister was taking Epitalin and she'd responded beautifully to it as far as enhanced restorative sleep. And this other patient started to experience menopausal symptoms, hot flashes. She was miserable. She wasn't sleeping well. And her sister said, take some of my Epitalin. Not only did she sleep better, her periods normalized. Interesting. One of the things that Epitalin is known to do is increase hypothalamic pituitary, hormonal secretion that controls ovarian function. So that improved things to the point where her periods normalized again. Now, that doesn't mean it's going to continue to do that indefinitely.
51:49She's still facing menopause in the face, but it did kick the bucket down the road for a time, which I thought was pretty interesting, right? Okay. Next question, ADHD. Is there a peptide out there that helps with that? That's a bigger, more complex question to answer. ADHD, in my opinion, is very proportional to mitochondrial function. So there are a lot of things that go into optimizing mitochondrial function. And you don't want to skip the foundationals. Omega-3, another of your foundational products that is critical. If you're omega-3 deficient, and only 94 % of Americans are, ADD is going to continue to be a problem.
52:30You really should measure that. You can measure omega indices and make sure that your levels are where they should be. So first and foremost, foundational things, right? Anti-inflammatory diet, omega-3s, get those phospholipids, another important category of fats for the brain, getting restorative sleep again. And then as far as peptides go, it's not a peptide, but methylene blue, as you're probably very familiar with, and we do have that in our line of products, is incredible for mitochondrial function. The reason people notice improved cognition, focus, speed of processing when they take methylene blue is because it's helping mitochondria.
53:04The brain is extremely mitochondrially active. It weighs 2 % of our body. It produces 20 % of our ATP production. So you boost mitochondrial function through various strategies, and that's going to improve. Now, are there other peptides that are specific for mitochondria? Yes, MOTC, SS31, those are typically injections. Can you do them in a nanospray, orally, nanospray, nasally? Sure, and that's going to have some benefit there as well. CELENC is another one. CMAX is another one that can be used in nasal spray or injection. Those are pretty incredible for the brain. CELENC is incredible for anxiety.
53:42The list goes on. I mean, there's just so much that these can do. But as far as treating ADD, are there peptides that can support that? So instead of running to Adderall, maybe we should be running to omega-3s, methylene blue, and some of these peptides. Absolutely. And we see results. I've been able to get a lot of people off prescription stimulants just with the addition of methylene blue. Interesting. Okay, let's do PCOS. Ah, so PCOS is a downstream effect of the immune imbalance, gut inflammation, and hormone dysregulation. So the brain gets inflamed, we start to see hormone dysregulation, we can measure that.
54:19So I treat everything rather similarly. So again, focusing on the foundational things, they're typically insulin resistant, which tells me their mitochondria are not doing well. So in those situations, I'm going to look at all of it. I'm going to treat all of it. I'm going to treat the unbalanced immune system. I'm going to treat the inflammation. I'm going to change their diet. I'm going to enhance their sleep. And I'm going to give them the specific peptides that they need based on those inflammatory markers and hormone levels that I'm looking at. But But with PCOS, if we can really optimize their mitochondrial function, we're going to see improvements.
54:51What about someone who just wants healthier hair and skin? Ah, yes. That's a trendy one right now for my friends. We're aging. Yeah, yeah. G-H-K-C-U, a copper peptide, very popular for its ability to improve collagen, thickened hair. That can be used. The injection, one of the ones that should be lifted, the band should be lifted on that one. Doesn't mean it's not out there. But it also works topically. So there are topical products, hair serums, things like that. Not only helping with hair, but with collagen. So application topically for other reasons can really be beneficial there. Let's talk about GHK just for a second.
55:30Please. Is that one you have to dose or you can take it every day? I would cycle off of that one, at least in theory, potentially if you're not monitoring copper levels, you probably want to cycle off that periodically. It can work orally, by the way. I was just going to ask, is orally just as good as the injectable or no? If it's in a liposomal formulation. Okay. But that would need to be in a liposomal formulation. Do you sell that one? Not yet. Not yet. Yeah. Coming soon, maybe. There is a Quicksilver Scientific that we sell on the shelf, but we'd like to make our own. Okay. Let's do weight loss.
56:03What's your favorite weight loss? The one that's not yet in the market. Okay. The one you're trying out. The GOP3, the Red Trutide, or some like to pronounce it, Red Trutide. But yes, that's that much better than the GLP-2, the terzipatide. But people are getting that one. We're getting it for research purposes only. Yeah, I can't prescribe it. I can't officially recommend it. Is it out there? Yes. Is it available? You sure? It is. Yes, yes, yes. I must know too many people that do peptides. Yeah. All right, last one, anxiety and depression. So interestingly, this is a long answer, and I apologize.
56:38I'll try and shorten it. But a fabulous book written by Chris Palmer, a psychiatrist out of Harvard, a researcher called Brain Energy, showed in his research that mood disorders are directly proportional to drumroll mitochondrial function. So anything and everything that helps mitochondrial function is going to help mood disorders. That said, specifically, Selenq and C-Max are a couple of peptides that are particularly good for anxiety and depression. But once again, anything and everything that you can stack for mitochondrial enhancement is going to have a significant bearing on anxiety and depression.
57:12Sleep alone is an enormous factor for mood disorders. So even just using the epitalin, for example, to restore those quality stages, those restorative stages of sleep, is going to have a big, big impact on mood disorders. Well, mood disorders also, I mean, again, foundational health of you've got to eat right. We need, you know, these correct nutrients. B vitamins are so important. Omega-3s are so important. So, again, it comes down to the foundational pillars. And then peptides, to me, are a tool in the toolbox to help people feel healthier. But they're not the be-all, be-all. It is another tool.
57:50Because to me, I'm like, if you're going to eat Oreos all day and ice cream at night and Frosted Flakes in the morning or something, the peptides aren't going to be your magic pill. Correct. But they are an amazing tool in this toolbox that is helping people become healthier, living a longer life, a life more of energy and happiness and things like that. Would you say that's true? Absolutely. Okay. Well, thank you so much for answering so many of these questions. I feel better about people taking peptides. I was a little nervous with so many people that I know taking so many different ones. And so I feel like if they're sourcing them correctly, getting them from a correct spot, working with a doctor, knowing how to use them, they can be really beneficial.
58:32One last question. Do you think this is going to be the new wave of medicine? I think it'll continue in this direction. The science is there. Like it or not, I see AI getting involved in this to kind of help with some of the complexity of all of this. I kind of see that's where we're going. But we have to train AI, and that takes an ability to see things perhaps from a bigger picture to really be able to prioritize, because it's complex. There's 7 ,000 of these, and it is complex. But that's what I see in the future. We'll continue to make gains in our experimentation, if you will, in the data that we're collecting, the safety data and more.
59:16We'll continue to make gains. but I do see in some degree AI helping us forge forward to kind of figure out some of the nuances with this like it or not like it or not right I can't wait to see what that all foretells all right well thank you again so much for being here like I said I've learned a lot I know the listeners have tell people because I know we're going to have so many questions I'm a little worried for the dms that are going to come in because just peptides is new to a lot of people So we're all just trying to understand them and sift through the noise. And so where can they find your peptides?
59:50Where can they find you? Haven-Wellness.co is where they can find information on our peptides. And there's some decent information there. They can find me at Integrated Medical Associates. My practice is pretty full. Your practice is very full. That's where I'm at currently. And on social media? At KetoTri.com. And then you do have a book coming out talking about SIRS, the foundational pillars, the peptides, correct? Yes. I'm excited about that. Tell them the name of that. Big Picture Medicine, the subtitle is a little lengthy. Optimizing health and wellness through functional medicine and peptide integration.
1:00:26And it's not quite available yet, but soon coming. Yes. Okay. I always end my podcast by asking five quick questions. Sure. And so I'm going to ask you those. First question, what emerging health topic are you most excited about right now? Probably what we talked about earlier, meaning AI-driven health optimization is what I see the future of where we're going with all of this. And I think we're going to get more and more information on peptide safety and efficacy. Like I said, I'm excited about that. Okay, number two, what's a piece of advice you'd give your younger self? That's a great one. Stop trying to prove yourself.
1:01:03Slow down. Love and share. Oh, I love that. Okay, number three, what's the one health practice you'll never compromise on no matter how busy life gets? This has changed over the years. I think at one point in time it was diet because I was very, very rigid with a healthy version of a ketogenic diet when I was competing in the Ironman. And exercise was a big emphasis then as well. These days, it's sleep. Oh, interesting. It's sleep. I won't compromise in my sleep. I love that. I'm getting better at that. Next question. And what's your favorite Just Ingredients product and why? It's not just one.
1:01:39And I would say the foundational products, Omega-3, Magnesium Complex, Probiotic Complex, the Fiber Drink. So those are probably my top four because they're so foundational. Oh, I love that. Thank you. And last question. What is the best ingredient you've found to life? Gratitude. I love that. On that note, thank you so much for having me. Well, thank you so much for being here. And again, followers, go check out his website. you can read more about all the peptides there because I know you'll have a lot of questions you can dm him maybe on social media and get answer questions there but hopefully you learned a lot and thank you so much join us for next week thank you for being here and being part of this community don't forget to subscribe to the just ingredients podcast we've got so much more to share with you and if you're not already come join us daily on all social media platforms at just.ingredients.
1:02:34Until next time, keep choosing what nourishes you.
From the publisher
In this episode, I’m excited to bring you my conversation with Dr. Porter, an expert in peptides and Chronic Inflammatory Response Syndrome (CIRS). This is an eye-opening discussion, especially if you’ve been dealing with things like fatigue, brain fog, or just not feeling like yourself and haven’t been able to find clear answers.
We talk about CIRS and how it comes back to chronic inflammation in the body. Dr. Porter explains how so many common symptoms we experience are actually connected to this ongoing inflammatory response and how our immune system, gut health, and overall wellness are all deeply linked.
We also dive into peptides—what they are and how they work as signaling molecules in the body. I loved how he broke this down in a simple way. Peptides basically help cells communicate and regulate different functions in the body.
And something I really appreciated from this conversation is Dr. Porter’s reminder that foundations matter most. Before anything else, we have to focus on the basics—eating an anti-inflammatory diet, managing stress, and prioritizing good sleep. Peptides can be supportive, but they’re not a replacement for those core lifestyle pieces.
I think you’re really going to love this episode. It’s practical, empowering, and gives a new way to look at chronic health challenges. Let me know what you think after you listen.
Bio:
Stuart B. Porter, D.O. is a distinguished leader in functional medicine and regenerative therapies. He is board certified in Family Medicine and a Fellow of the American Academy of Family Physicians. A graduate of Brigham Young University (B.S., Design Engineering, 1984) and Kirksville College of Osteopathic Medicine (D.O., 1988, graduating first in his class), Dr. Porter went on to complete his Family Medicine Residency at Madigan Army Medical Center in 1993.
From 2003 to 2021, he served as Regional Dean for A.T. Still University’s Kirksville College of Osteopathic Medicine in the Utah Region, mentoring hundreds of medical students over decades of academic leadership. He is certified in peptide therapy through the Seeds Scientific Research & Performance (SSRP) Institute and has become a trusted voice in integrating advanced peptide science with functional and regenerative medicine.
Dr. Porter is the founder of Integrative Medical Associates in Provo, Utah, and co-founder of Xage Medical Spa, a regenerative aesthetics practice. His clinical protocols have helped elite athletes, entertainers, and individuals from all walks of life achieve peak performance, longevity, and optimal health.
Beyond medicine, Dr. Porter is an accomplished endurance athlete. He has competed in numerous Ironman Triathlon races, qualifying for the Ironman World Championship five times. In 2017, he was ranked first in the US and fourth in the world for full-distance Ironman competition. His passions include backcountry skiing, mountain biking, boating with
family and friends, and embracing the outdoors as part of a lifelong commitment to fitness and vitality. He loves serving in his religious community and spending time with his wife of 43 fabulous years, his 5 children and 9 (2 of those are on their way!) grandchildren.
With Big Picture Medicine: Optimizing Health and Wellness Through Functional Medicine and Peptide Integration, Dr. Porter shares his clinical insights, athletic experience, and dedication to helping others unlock their full potential for health and well-being.
Connect with Dr. Stuart Porter:
Instagram: ketotridoc
Websites: http://xagemedicalspa.com/ and http://integrativemedutah.com and http://bigpicturemedicine.co/
Peptides may sound intimidating, but as Dr. Porter shares, the right ones support energy, sleep, recovery, and healthy aging—learn more at havenwellness.com/justingredients
We love Active Skin Repair! Get 20% off with code JUSTINGREDIENTS: https://shop.bldgactive.com/JUSTINGREDIENTS
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