Podcast · 489 episodes
The a16z Show, page 6
by Andreessen Horowitz · English
The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
All episodes, page 6
Balaji and Taylor Lorenz on AI and MediaHow AI is breaking media trust and what should replace it: decentralized, cryptographically verifiable “truth” (not paywalled), human-only social networks, and new verification methods (cryptographic…1 May 2026 · 52 min · 22 chapters
Workday’s Last Workday? AI and the Future of Enterprise SoftwareAI-driven “replatforming” of entrenched enterprise software, using Workday as the example; why incumbents face “obituaries” and how an AI-native Workday would enable faster, cheaper rip-and-replace.30 Apr 2026 · 29 min · 15 chapters
The Shift in Global Drug DevelopmentThe episode argues that global drug development is shifting from U.S.29 Apr 2026 · 58 min · 27 chapters
John and Patrick Collison on Stripe's Growth, Agent Commerce, and the Future of SoftwareStripe’s annual letter and what Stripe data says about the real economy; why “agentic commerce” will surge; and how AI + stablecoins point to needing higher-throughput blockchains and new software…28 Apr 2026 · 20 min · 12 chapters
Ben Horowitz on Venture Capital and AIBen Horowitz (A16Z) explains how venture capital’s “system” evolved from 2009 to today, and how AI is shifting the bottlenecks from software engineering to compute/energy and organizational design.27 Apr 2026 · 1 h 9 min · 29 chapters
AI Inside the EnterpriseEnterprise adoption of AI/agents—why “more AI” initiatives fail, where integration breaks, and how “headless” software and agents change architecture, permissions, and business models.24 Apr 2026 · 1 h 1 min · 27 chapters
Martin Shkreli on AI, Pharma, and What Actually MattersMartin Shkreli discusses what matters in AI (economic value capture vs benchmarks), the AI/hardware bottleneck (compute limits), and where leverage is shifting across AI, photonic computing, and…23 Apr 2026 · 49 min · 21 chapters
Balaji Srinivasan: Prove Correct, Not Just Go DirectReplacing “go direct” media and institutional trust with “prove correct” systems using cryptography, mathematics, and on-chain/verifiable records.22 Apr 2026 · 2 h 2 min · 49 chapters
Marc Andreessen: Monitoring the Situation and the Future of MediaThe episode argues that media’s structure drives political and cultural behavior, and that “current things” spread as viral outrage cycles on social platforms, especially X.21 Apr 2026 · 1 h 7 min · 28 chapters
Rethinking Git for the Age of Coding Agents with GitHub Cofounder Scott ChaconHow Git’s 2000s Unix-philosophy CLI and UX don’t fit agentic/AI coding workflows, and what should change vs stay the same.20 Apr 2026 · 47 min · 21 chapters
Network Effects, AI Costs, and the Future of Consumer Investing with Anish Acharya on The Kevin Rose ShowHow AI changes consumer startup moats, coding/productivity, and venture economics; plus AI’s societal implications (jobs, purpose, safety) and future consumer investing.19 Apr 2026 · 59 min · 31 chapters
The System Behind Self-Driving: Waymo’s Dmitri DolgovHow Waymo built its fully autonomous driving stack and scaled from research to deployment, including sensor fusion (cameras, LiDAR, radar), AI “foundation model + teachers (driver, simulator, critic)…17 Apr 2026 · 1 h 4 min · 33 chapters
Technology, Culture, and the Next AI Interface with signüllHow AI is changing culture and “personality” in models, why most people use AI only at a basic level, and what the next AI interface should feel like (ambient, agentic, cheaper access).16 Apr 2026 · 34 min · 17 chapters
Replit's CEO on Vibe Coding, Wealth Building, and What Most People Get Wrong About AIReplit CEO Amjad Massad explains “vibe coding” (building apps by describing them to AI), why AI won’t simply “kill jobs” but will shift work toward generalist business builders, and how to generate…15 Apr 2026 · 1 h 39 min · 40 chapters
Ben Horowitz on AI Infrastructure, Economics and The New Laws of SoftwareAI’s “new laws of software” and how CEOs, venture capital, and crypto infrastructure must adapt to bottlenecks (chips, memory, electricity), faster software development, and eroding moats (lock-in,…14 Apr 2026 · 30 min · 13 chapters
Building Agents at Home: Parenting, Work, and Benevolent NeglectA YC founder-turned-homeschool mom explains how she uses AI agents at home to “break the cycle” of rising household standards (more laundry/meals, same hours) by automating planning, shopping, and…13 Apr 2026 · 55 min · 20 chapters
What Running Windows at Microsoft Taught Steven Sinofsky About AppleSteven Sinofsky compares Apple vs Microsoft culture and product outcomes, using Windows release history, DirectX, and Apple’s “taste” to explain why Apple reshaped computing and why Windows faces…10 Apr 2026 · 31 min · 13 chapters
Who Controls AI Acceleration? Vitalik Buterin and Guillaume Verdon DebateA debate on “effective accelerationism” (EAC) versus “defensive acceleration” (DIAC/DAC) about how fast AI should advance and who should control its acceleration.9 Apr 2026 · 1 h 39 min · 38 chapters
The Agent Era: Building Software Beyond Chat with Box CEO Aaron LevieHow AI “agents” will change enterprise software from chat-based coding to agent-driven computer use, API/CLI access, and runtime integration; the key challenge is economics, reliability, and security…8 Apr 2026 · 1 h · 31 chapters
Balaji on Why AI Raises the Cost of VerificationBalaji Sreenivasan argues that AI lowers the cost of creating content and tools, but sharply raises the cost of verification, reshaping markets into “trusted tribes” and increasing demand for…7 Apr 2026 · 1 h 7 min · 32 chapters
Peter Yang on Small Teams, Coding Agents, and Why Human Ambition Has No CeilingCoding agents and the “agent stack” replacing many app workflows; why apps may decline as tasks shift to agents; future company structure favoring small teams; impact on work, productivity, and job…6 Apr 2026 · 29 min · 17 chapters
Marc Andreessen on AI Winters and Agent BreakthroughsMarc Andreessen argues the current AI surge is “80-year overnight success,” not another AI winter.3 Apr 2026 · 1 h 17 min · 39 chapters
Alex Blania on Proof of Human and Building World's Identity Network“Proof of Human” for the AI era—how to verify that online accounts are unique real people (not AI agents) and how World is building a “real human network” using iris-based hardware plus privacy tech.2 Apr 2026 · 42 min · 15 chapters
What Happens When a Public Company Goes All In on AIBlock (parent of Square, Cash App, Afterpay) restructures around agentic AI after models suddenly became far better at working with complex codebases, breaking the “headcount equals output”…1 Apr 2026 · 28 min · 12 chapters