In short
Accelerated cellular aging and “cellular confusion” (epigenetic/genetic mismatch) driving mitochondria dysfunction, inflammation, and uneven organ aging; how to measure it via biomarkers and what to do to slow it (fasting-mimicking morning routine, exercise, diet, stress/spiritual practices, and reducing environmental exposures).
Guest
Dr. Will Cole, functional medicine expert; New York Times bestselling author; pioneer in functional medicine telehealth.
Key claims
People born after 1965 show faster cellular aging than earlier cohorts; Gen Z/millennials may age faster than 1965-born peers. Mitochondrial dysfunction can feel like brain fog and fatigue (“tired, wired and anxious, but exhausted”). Organ-specific aging can diverge (Stanford: ~1 in 5 adults over 50 have accelerated organ aging; heart aging linked to >200% heart-attack/stroke/heart-failure risk; brain aging linked to ~80% neurodegenerative risk). Chronic disease is framed as downstream of cellular clock acceleration and cell danger response, mTOR elevation, and impaired sirtuin cleanup.
Notable examples
Friends’ husbands dying in their 40s despite “picture of health”; father’s sudden cardiovascular event after appearing healthy; Stanford studies on 11 organs and cell-type differences within the heart.
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VOUnderstanding Cellular Aging
0:34 to 2:20
Discussion on the alarming rates of aging among younger generations.
“In the last year, six of my friends lost their husbands in their 40s.”
The Impact of Accelerated Aging
2:20 to 4:14
Exploration of how organ aging varies and its implications on health.
“Beyond good branding and strong claims, what does the evidence show?”
Cellular Confusion: The Root Cause
4:14 to 7:26
Examining the reasons behind cellular confusion and its effects on the body.
“I want to circle back to this organ idea.”
Understanding the Body's Defense Mechanism
7:26 to 11:24
How environmental factors contribute to cellular aging and health problems.
“So we go through in the book the key things that I have seen on labs.”
The Importance of Biomarkers
11:24 to 13:30
Discussing the significance of biological markers in assessing health risks.
“I was recently in a conversation and someone said, you know, would you say that all you have to do is correct your hormones and you can correct your mitochondria?”
The Health Paradigm Shift
14:00 to 16:10
Explore the need for a shift in how we view chronic health issues.
“because one of them had just completed an Ironman, another one marathon runner.”
Markers of Health We Overlook
16:44 to 19:22
Discussion on overlooked health markers and their implications.
“So we need to look at these inflammation markers, these cardiometabolic markers.”
The Importance of Spiritual Connection
19:22 to 21:40
Examining how spiritual practices can impact health and longevity.
“We're divorced from our relationship with God, in my opinion.”
Nature's Influence on Well-Being
21:40 to 24:10
How connection with nature and practices like forest bathing benefit health.
“There's always been this spiritual component that we've seen throughout history.”
Accelerated Aging Factors
24:10 to 28:00
Understanding the key factors driving accelerated aging in modern life.
“And one thing I will say, you know, for people like an actionable thing.”
Show all 24 chapters
The Impact of Light on Cellular Health
28:00 to 29:18
Learn how exposure to different light spectrums affects cellular rhythms and health.
“Like you're out moving your body, you're in that light.”
Understanding Mitochondrial Dysfunction
29:18 to 31:20
Discover the symptoms and implications of mitochondrial dysfunction on health.
“I think those five areas are what's accelerating our cellular clock and creating the cellular confusion, the static that's inhibiting our cells to recognize what they're supposed to do.”
Connecting Mitochondria and Fatigue
32:02 to 33:11
Explore the connection between mitochondrial health and fatigue in various conditions.
“I mean, the fertility issues oftentimes has a mitochondrial component, diabetes.”
Morning Protocol for Cellular Health
33:11 to 39:09
Learn a practical morning routine that enhances cellular health and resilience.
“So in the first round, I want to ask you, these are questions that come from our listeners.”
High-Intensity Interval Training for Longevity
39:09 to 42:00
Understand the benefits of high-intensity interval training and its effect on cellular health.
“Because if you didn't sleep well, maybe you're not going to do a big long fast.”
Understanding High-Intensity Interval Training
42:00 to 43:51
Learn about the benefits and structure of high-intensity interval training for cellular health.
“to be high intensity for the next person.”
Building the Best Plate for Longevity
43:51 to 46:02
Discover how to construct a nutritious plate focused on longevity and gut health.
“The re-hit that I mentioned earlier, that sort of aggro hit, you're only supposed to do that two or three times a week every other day.”
Five Essential Foods for Longevity
47:55 to 49:45
Explore five key foods to include in your diet for improved health and longevity.
“to their grocery cart this week, what five things could really make a difference?”
Foods to Avoid and Bioindividuality
49:45 to 52:14
Understand which foods may not work for everyone and the concept of bioindividuality.
“I think for the vast majority of people, just doing the best they can and giving the rest to God and not stressing about things that are healthy, which isn't good for your health either, is good enough.”
Improving Metabolic Health After Meals
52:14 to 56:00
Learn strategies to improve metabolic health and blood sugar levels after meals.
“I want to ask you so this person said okay I have metabolic instability I don't have diabetes yet but there are signs of insulin resistance.”
The Importance of Light Hygiene for Sleep
56:00 to 58:50
Learn about the impact of light on sleep and strategies to improve sleep quality.
“So that's going to really back to that dirty light that we talked about.”
Practical Tips for Busy Parents on Longevity
58:50 to 1:02:02
Explore simple and effective strategies for busy individuals to enhance longevity.
“What would be like five things that I could do in the day that's going to help my longevity, that's not going to create an exhaustive morning routine, nighttime routine, or it require like extensive meal prep?”
Mobility vs. Stretching: A Discussion
1:02:02 to 1:05:19
Understand the benefits of mobility work compared to traditional stretching for longevity.
“But look, it's like we are not sort of ideologues in the sense of, I mean, you look at some of these carnivore guys.”
Promoting Accessibility in Health Protocols
1:05:19 to 1:07:01
Discuss the need for health practices to be accessible and manageable for everyone.
“Well, I don't do either flexibility, stretching or mobility.”
Transcript
Automatic transcript. May contain errors.0:00People in their 20s, 30s, and 40s that have senior citizen cells are aging more rapidly than people born in 1965 at the same age. What does it feel like when your mitochondria are not working optimally? The telltale signs, it's brain fog and fatigue. It's, I'm tired, I'm anxious, but exhausted. Fertility issues oftentimes has a mitochondrial component. Dr. Will Cole is one of the nation's leading functional medicine experts, a New York Times bestselling author. And a pioneer in functional medicine telehealth. Now he's taking us inside the science of cellular health. And what it could mean for how you feel, heal, and age.
0:37In the last year, six of my friends lost their husbands in their 40s. If your heart cells were aging more rapidly than the rest of your body, you had over a 200 % increased risk of heart attacks, stroke, heart failure. I wake up tomorrow and I want to start taking better care of my cells. Walk me through the first 30 minutes of my morning. There's a lot of amazing things you can do, but I would say... If someone's driver's license says they're 35, how old could their body actually be? It depends on how quickly or how slowly those cells are aging, but there is an epidemic rise, I would argue, of people in their 20s, 30s, and 40s that have senior citizen cells.
1:17Their recent study just a few months ago, June, I believe, it was published in Nature, that found that people born after the year 1965 were aging more rapidly than people born prior to 1965 at the same age. And even more, shockingly, maybe to some, maybe not to you and I, but people born in the 90s, people that are millennials, Gen Z, are aging more rapidly than people born in 1965. Meaning that from 1965, 70s, 80s, 90s, 2000s, every decade, people's cells are aging more rapidly. But the beautiful news is that our body's amazingly resilient. We just need to wake up ourselves to actually function that they were created to.
2:01We have an epidemic rise of accelerated aging and then not just accelerated aging, but uneven aging. Certain people's organs are aging at different speeds as well. Yeah, I want to get into the different organ aging for sure. But I want to talk about, so there's biological age, there's cellular age, there's organ age, I want to help people understand what's real, what's marketing. Beyond good branding and strong claims, what does the evidence show? And I mean, science, good quality study, but also someone that does this for a living, like what actually moves the needle as far as the labs are concerned on a clinical level, like to me, that's what matters.
2:40Like if I can improve somebody's metabolic markers, inflammation markers, cardio, cardiovascular markers, that's what matters. I mean, the labs don't lie. And that's sort of the world that you and I come from. And I don't pay that much attention to how much all the things that people are marketed to. I hear about it firsthand, but I'm not necessarily looking at the marketing. So the difference between chronological age and biological age, chronological age is just how many birthdays have you had. Your actual cellular age, the biological age is something that we need to be mindful of because there's a disparity, right?
3:18There's a mortality gap or a morbidity gap. The United States is actually having some of the biggest gaps there are as far as the research is concerned. We spend the most for it too, which is really great. We have most chronic disease, the shortest lifespan, the shortest health span, meaning the amount of years of health in Western society. And that's because of, I mean, all these statistics are out there, but really what's happening is cellular confusion is how the researchers refer to it as this information theory, this information model of understanding how cells are aging. It's because our cells lose recognition of self.
3:59The brain cell forgets that it's a brain cell. The heart cell forgets that it's a heart cell because of this epigenetic genetic mismatch. Our DNA, our cells are living in a brave new world because of this way that we're living our life today. and when I mean it really could be boiled down to when humanity pretends to be god there's unintended consequences and sometimes intended consequences be and and our our physiology is paying a price as far as accelerated aging so you can look at the statistics of people living longer that's not a good quality quality living we're keeping people alive but we can't keep them healthy the way that we're doing they're hopped up on medications lonely in a elderly home uh and And that's not a good quality of life.
4:44I want to circle back to this organ idea. So just for everyone listening later, I'm going to have you build an exact like morning to night protocol that you would give someone that wants to support healthier aging, longevity, and isn't looking for just like one single biohack. So we're going to get into that. But there was a Stanford study that found that roughly one in five adults over 50 had at least one organ aging at an accelerated rate. How can someone's heart theoretically be older than their brain or their kidneys? It was one of the hallmark studies that we talk about in the book that that's equal to, Dr.
5:22Brighton, about 22 million Americans have one organ aging more rapidly than others. And what that means on a practical level, if your brain cells were aging more rapidly than the rest of your body, you had, according to the study, about an 80 % increased risk of some neurodegenerative problem like Alzheimer's or Parkinson's or something like that. If your heart cells were aging more rapidly than the rest of your body, you had over a 200 % increased risk of heart attack, stroke, heart failure, something like this. The researchers at Stanford looked at 11 different organs, all the most common organs that people have chronic diseases in.
6:00That was in 2023. There was a follow-up study just a few months ago that found that even within the same organ, like the heart itself, different types of cardiac cells will age a different. The fact that we have this accelerated aging, it is really why we're seeing this epidemic rise of autoimmune fertility and cardiometabolic issues in cancers is because of accelerated cellular aging. So it's why I wanted to write this book. It's because we see a lot just like you over the years, a lot of people somewhere on this autoimmune inflammation spectrum. And we talk about molecular mimicry, right? And it's like systems, it's organs itself.
6:38When the immune system attacks the thyroid, it's Hashimoto's disease or Graves. If it's the gut, it's all sort of colitis or Crohn's. Yes, these are organs, but beyond that, what's beyond what's actually happening? It's cellular confusion. It's this clutter or static or noise that's confusing our cells. When you say this static, this cellular confusion, what is actually happening? at the cellular level that's causing this rapid aging of the cells. I see all of this through the lens of more or less an ancestral perspective, that our genetics haven't changed in thousands of years. Our microbiome hasn't changed in longer.
7:16But yeah, our world has changed dramatically in a short period of time. So this evolutionary mismatch, this genetic epigenetic mismatch, this chasm between our DNA, the microbiome, and the world around us, that is creating a misalignment, if you will, or the cellular confusion. So we go through in the book the key things that I have seen on labs. When you address them, they start to move biomarkers in a positive direction, whether it's the foods that don't love your body back, it's eating too much too often as far as the fasting windows are concerned. Is it stress and trauma? Is it environmental toxins?
7:57There's different areas that researchers are pointing into when they're in the body, the cell says, what do we have? The cell danger response. This ancient pathway is there to protect us, but the cell danger response cannot distinguish between physiological and psychological threat. It's trying to protect you. So what does it do on a cellular level? That cell membrane, this protective layer around the cell, this phospholipid membrane becomes more rigid, becomes less permeable. So it becomes more oxidized, more inflamed, more hypervigilant. And you think about that on a personality level. The people, when they're dysregulated, inflamed, they feel more defensive.
8:36They feel more hypervigilant. That's what came first, the chicken and the egg. I would argue that it's that hyperdefensiveness, that protection mode is happening on a cellular level first. And then the mitochondria, which are meant to be that cellular energy factory, starts becoming leaky, Sort of like we have leaky gut syndrome, we have leaky mitochondria syndrome, producing these reactive oxygen species, these inflammatory oxidative stress in the cell. And what happens then is that the DNA, it's this pristine code, becomes these micro tears that stress out the DNA. So these guardian angels of our cell, these sirtuins, which the acronym stands for silent inflammation regulators, back to the information regulator, where they're meant to regulate information.
9:26but they're having a hard time keeping up with the amount of this mismatch this epigenetic genetic mismatch they're trying to clean up the mess this pathway called mTOR starts increasing mTOR stands for mammalian or mechanistic target of rapamycin it's there god made mTOR there's nothing inherently wrong you need it to build muscle but the problem is because of this mismatch we're living in this brave new world out of alignment with nature mTOR is always high and it's this pro-growth pathway that becomes a lot of debris from this sort of building always on mode and the sirtuins are having a hard time cleaning up the biological wastes or environmental toxins from the mTOR pathway and then that sort of micro tears from the dna and they kind of researchers refer to it as like they almost like lose their way and then when one cell becomes inflamed and dysregulated, I think of the symbolism of this, they don't just hurt themselves.
10:24They start to infect, if you will, or disturb and dysregulate the people, the cells around them, as we can be. When we're dysregulated, hypervigilant, and irritable, we impact the people around us, as above, so below, as within, so without. We are part of nature. And this is happening from a climate environmental standpoint. The earth is inflamed and it's happening on a cellular level. These sort of cellular earths, if you will, are inflamed as well. I appreciate that you talk about this in a way of how it is the body compensating and it's the body's defense mechanism. Because I think there's a lot of medicine that sees the body as misbehaving, something to be controlled, something to be suppressed, something that has gone wrong because it was inherently broken.
11:09And what gets left out of a lot of these conversations is that so much of what the body is responding to is this mismatch in the environment. And the response is correct. What's incorrect is the constant inundation of environmental toxins, inflammation, the things in our environment that we know disrupt our mitochondria. It was very interesting. I was recently in a conversation and someone said, you know, would you say that all you have to do is correct your hormones and you can correct your mitochondria? And I was like, I wish that was the case. You can correct your hormones. And if you don't, you won't be able to address the mitochondria.
11:45But I feel like in this modern environment, if we don't look at every single piece like you're looking at within your new book of what is actually impacting us at a cellular level, what is disrupting, what was meant to be this flawless mechanism, maybe not flawless, sometimes the body makes mistakes, but it was meant to be harmonious. And now we have disharmony because of what is happening within our environment and how it's impacted our body. You talked about testing. One thing I'm curious about is like, what's the biggest gap between biological age and chronological age that you've been able to see and that you've been able to help reverse?
12:21When you're looking at DNA methylation and cardiometabolic markers, it's way more than one in five people are aging more rapidly. anywhere between a few years difference, meaning your cells are, the cellular clocks are ticking faster, maybe by a few years. And some people's cellular clocks are ticking by decades. The statistics also show that about 50 % of people who have heart attacks and strokes, their first symptom is death, meaning that they are, they, they're quote unquote fine. It's the pandemic, it's the epidemic of baby boomers that are here one second and gone the next. I talk about what happened to my dad in the book where he was the quote unquote, the picture of health was driving to the airport to pick up my mom and then had some sort of cardiovascular event, lost consciousness and crashed in the car and broke his neck.
13:09I mean, how many people do we know that that maybe not as dramatic as that, but people that are here one second and gone the next, why, why you would say, oh, they're healthy. There's, there's, there's nothing wrong with them, but it's no, these cells were aging more rapidly. And if we just would be able to look at these biomarkers of somebody that was going through that, we could actually do something about it. While these statistics are sobering, I mean, one in two Americans are going to be facing a heart attack or stroke, but these things are largely overcomable, healable, reversible. You can do something about it.
13:39Yeah. Well, firstly, I'm so sorry to hear about your father. And this is a conversation that I've been having more in the last year, six of my friends lost their husbands in their 40s. Six of my friends lost their husbands in their 40s. And my husband just turned 40. And I definitely have been riding him maybe a little bit too hard in terms of being like, you just don't understand because one of them had just completed an Ironman, another one marathon runner. Like, these were people who were the picture of health, who didn't drink, who didn't smoke, who never smoked, who had for all intents and purposes, live their life like perfectly, right?
14:22Like the picture of health. And yet there are so many things that I think conventional medicine is not screening for, not testing for. And these are some of the things you're talking about. When you talk about DNA methylation, what should people be asking their providers for? What should the providers be looking for? So sorry to hear about your friends and what they went through. I mean, it's just, and we're talking about heart attack and stroke here, but then you think of all the younger people in their 20s, 30s, 40s that have these cancers that used to be, I mean, all of this stuff used to be later in life, elderly problems would be heart attack and stroke.
14:57Now, 30s and 40s are having these problems. I mean, type two diabetes used to be called adult onset diabetes. Now it's, I think the shocking statistic, around 30 % of preteens and teens are pre-diabetic. I mean, it is wild. The younger you are, the chances are statistically you're aging more rapidly. So we have such a reactive medical model. It's they're trained to diagnose the disease and match it with a corresponding pharmaceutical drug. So they are not caught up with the times of where we're at, that's not going to cut it anymore. And that's why the stats do speak for themselves, why we are going bankrupt with sick care system.
15:38And we have very little to show for it as far as health outcomes are concerned when it comes to chronic health care, let me be clear. You know, I'm not talking about ER acute emergency care. I'm talking about someone living a long, healthy, thriving life, dealing with these chronic health problems. If your ADHD feels different across your cycle, postpartum, or in perimenopause, ADHD in Women explains why hormones can change your brain and what you can do about it. Pre-order now and for a limited time, get the first chapter audio read by me, Dr. Jolene Brighton, for free. Plus a bunch of other bonuses like a free recipe guide and a PMDD workshop.
16:17Claim your bonuses at drbrighton.com slash ADHD in Women. That's D-R-B-R-I-G-H-T-E-N.com slash ADHD and women. Propel Fitness Water with Gatorade electrolytes, zero sugar and vitamins. Propel hydrates better than water to help you get the most out of your workout and get back to your best self. What propels you? Propel with Gatorade electrolytes. So we need to look at these inflammation markers, these cardiometabolic markers. Now, most of the stuff is conventional data. They're just not ran routinely. They're not looking at high sensitivity to see reactive protein, not looking at homocysteine levels.
17:00They're not having it. And look, even if they're running basic markers like A1C, glucose, and these triglycerides, they're not, and you see this, I know you've seen this too, they're not even having any meaningful conversations because the average doctor's visit is seven minutes. How the heck are you supposed to have any meaningful conversation in seven minutes? And then even if they wanted to have the conversation, the training in the mainstream medical schools, most doctors would fail a basic nutrition test, but that's the height of irony. And I would say malpractice because most of the people they're seeing are there because of lifestyle issues.
17:36So we have a whole paradigm problem. It's a whole paradigm problem. And it's obviously a lot of different variables to why that is, is a confluence of different factors, but it's a paradigm issue. We need to shift the paradigm. We cannot wait for the system to change, even though there is some pockets of change, we need to be responsible for our health and have agency on our health. It's our responsibility. But some of the more niche tests that are not in the conventional model, but I do think are implicated in the things we're talking about, this sort of cellular loss of recognition, this accelerated cell clock, are these environmental toxins.
18:14I think that the microplastics, the forever chemicals, the herbicides and the pesticides are one area that we need to talk about. They're not going to run those in the conventional model of care, but they are the, for many people, what's underneath the proverbial hood of why that high blood pressure, why the cholesterol, why the inflammation marker is high in the first place. So like someone like my dad or someone like your friends, someone that does the Ironman that's eating healthy foods to fuel themselves, do something rigorous like that. Well, science is looking at these microplastics and forever chemicals going into the arteries, creating a hyperinflammatory response.
18:59So again, back to this intelligent design, the body's trying to protect us, but it's this mismatch that's causing a problem. So I think there's both conventional labs that need to be run. Look, I'd be happy with just that. Even if they just were having meaningful conversations with some good inflammation and cardiometabolic markers, I'd be happy with that. some nutrient deficiencies, I'd be happy with that. The United States would be better for it. But then in a utopian world, like looking at these environmental toxins and then even better things that are not better, but even more so the things that can't be directly measured, but looking at chronic stress and unresolved trauma and the nervous system component to a lot of this, we're living out of alignment.
19:39We're divorced from nature. We're divorced from our relationship with God, in my opinion. And this spiritual disconnection that we're facing as a society is actually part of the problem too. That's definitely, you can't measure that directly, but looking at things like an ACE score, adverse childhood experiences and an ACE score of above four, which isn't even that hard to do. And it's looking at what you went through as a kid, exponentially 15, 30 plus X, your increased risk of autoimmune problems and metabolic problems. And of course, mental health issues. Had there been any studies regarding longevity and whether people are religious or spiritual in any way?
20:16Yeah, there's multiple studies that look at people that attended regular religious services or some sort of positive spiritual community is a big part of that. And you can even look at the Blue Zone with communities on that. But specifically, these studies are talking about religious services and that the decrease for all-cause mortality went down, I think 33 % was a specific study that comes to mind. decreased high sensitivity C-reactive protein. People that had a spiritual or faith practice, yeah, it's leaps and bounds. Now that can look different for different people. It may be prayer for one person.
20:53It could be meditation for one person. Dr. Lisa Miller, are you familiar with her work? She's at Columbia. She's looked at different parts of the brain and how people that had some sort of faith practice had these specific qualities across faith, across different faith traditions. And it really came down to grit and resilience. It's this sort of deeper knowledge that A, you weren't alone, there was community involved, but also this knowing that it wasn't all about you, that there was some, this larger deep peace that passes all understanding, as the Bible said. So I think there's, science really is looking at this, of how faith in someone's spiritual walk impacts their physiology.
21:39I think it's just interesting because especially in the context of the conversation of us talking about the evolutionary mismatch and as you were talking about, you know, connection to something like a higher power, having faith, you know, when you think about it, societies have always had this, you know, quote unquote, religious component. There's always been this spiritual component that we've seen throughout history. And I don't think that's something that I've ever considered and really have thought about in terms of like the components of health and like that through line of like, if you go back to any ancient society, there was some form of a God, there was some form of a higher power.
22:18There were practices, there were services, there were observances. And to really think about that in the modern age, if we've stepped away from that, I mean, this is something just for my audience, I don't have answers to this. This is not something I've looked at. This is just something I'm considering right now in this moment of like, that's as much as we have moved our body and we have slept and we have had community. We've also had these things throughout our lineage as humans. I absolutely agree. And for me, I think the closest I feel to God is getting out in nature. And you look at the research of Shinrin Yoku out of Japan and South Korea, looking at forest bathing and these, what I call it, God art, like taking in the majesty of nature, the ineffable of nature, some things you can see and smell and hear and there's something meditative to that.
23:03But there's some things that are just ineffable. I talked about this study the other day that just still like, when I think about it, there's something beautiful about it, is bird song. When you hear birds chirping, birds tend to chirp when they feel safe. And I think there's something on a cellular somatic level that tells our nervous system, our cells, that it's safe too. And those frequencies of nature, science is just catching up with the mechanisms of action of how these sound frequencies or the fight on sides of the plants, the actual essential oils from the plants has a modulatory effect on our immune system.
23:38So the way that nature impacts our nervous system, our immune system is profound. So I consider that a spiritual practice, right? To me, I connect with God and pray and use it as almost like an act of worship and having that sort of intimate moment. So let that be your spiritual practice. It's interesting you bring up the birdsong. I was just in Finland and their airport is full of birdsong. But I was like, I feel really chill right now in an airport, which I don't usually feel. It's so interesting you say that. And one thing I will say, you know, for people like an actionable thing. one of the things I started with my children from a very young age is we keep a nature table in our house.
24:19So when we're out on walks and we find things, I mean, I'm in my mid forties and I'm still in awe of a pine cone. I am still in awe of a pine cone. Like the, the, the way that it grows. I mean, and I think that's a really simple way to like observe nature, be with nature, bring nature into your home. And, um, I love our nature table. It's central to our home. And every time we pass by it, it's like a moment to be like, wow, sometimes it's a really cool rock. Like, you know, sometimes my boys are always about the really cool stick. It's always a cool stick for them. So I think there's really, you know, simple things that we can be doing that can help with not just modulating, you know, cortisol and our stress response, but overall, how we are aging, how we're feeling in our body.
25:04I want to ask you, you know, what do you think is driving accelerated aging the most? My list would be the foods we're eating and the foods we're not eating. This mismatch when it comes to food is concerned and the times that we're eating. So researchers refer to a lot of these chronic modern illnesses like autoimmune conditions and cardiometabolic problems, cancer, heart disease, et cetera, as chronobiological in nature. So we're eating too much foods that don't love us back too often. So there's the reprieve for these pathways, this mismatch. I think food is obviously the obvious, if you had to make a ranking list, I probably would put that up there.
25:44I would put man-made environmental toxins up there too, maybe even above the food piece. Cause I think if you look, we hear this all the time, people like you and I, well, my grandma used to ate whatever she wanted. My great grandma drank every night and smoked and she lived till she was 90 years old. That makes me think, well, maybe it's the environmental toxin pieces or probably more because sweet grandma wasn't swimming in Pifa soup by the time she was five years old or microplastics or whatever. She lived in a completely different world. We do not have the wiggle room that sweet Nana had. So environmental toxins, food, light confusion is another one.
26:25This sort of, we have this, the SCN part of the brain is that central brain clock. And it's that we have that connection from the central nervous system of clock and with our cellular clocks, this peripheral clock. So there's a, our cellular clocks are out of sync because we're constantly surrounded by, by blue light. We're on our screens. We're on our screens too late and it's impacting that sleep-wake cycle, which is profoundly needed for repair mechanisms, these autophagy pathways and other ones. So I think light would be on the top of my list, sort of dirty light, if you will. I don't want to call it, maybe that's a better term for that.
Read the full transcript
27:05I don't want to demonize it, but it's just unnatural light too often. I think as we've seen, the overhead lights have changed, right? Like you used to have your regular run-of-the-mill light bulbs. I wasn't born in the 90s, you guys. So I'm also not aging so rapidly. But now we have all of these LED lights, right? I would call it dirty light because, you know, I will share with you that I have a friend, he's very like on his game when it comes to evening. And we went to their house, we stayed at their house overnight, and it was all red light bulbs only, which was really hard to navigate through a house, I will say, when it's not your house, and you're like, where are the stairs?
27:46Where's everything at? But we slept so well. And we were talking about just how well we slept. And I don't think we ever get the opportunity as humans to really have that unless you camp, right? And I don't know who's out there camping. I grew up camping. And like, how well did you sleep? Like you're out moving your body, you're in that light. But if we think about, I don't know, I would go so far as to call it dirty light, because that blue spectrum should not exist. and it does not exist anywhere in nature when it comes to the evening. It is only the morning. And so it is very disruptive. I mean, from the hormone perspective, it is incredibly disruptive.
28:25And as you were saying, it's not just your circadian rhythm. Your gut, your skin, your organs all have their own rhythm and light is influencing that. Yeah. Every cell has these zeitgebers, I think is the term for it. These sort of light givers, these cellular clocks, basically. And yeah, they're out of sync. And we all have cellular clocks. Every organ has a cellular clock. Back to that Stanford study is someone's heart cells are ticking and talking faster. Someone's brain cells are ticking faster. A lot, 25 million plus, I would assume more if they're looking beyond just these proteins that Stanford was looking at, they're aging faster.
29:02And that is why it is a cellular reason why we have all of this chronic disease. And then the last two real quick is I would say biotoxins like mold, bacteria, viruses. And then the last piece is stress and trauma, the mental, emotional, spiritual piece. I think those five areas are what's accelerating our cellular clock and creating the cellular confusion, the static that's inhibiting our cells to recognize what they're supposed to do. Okay, so in a minute, I want to make this all really practical. I'm going to ask you to build a protocol. We're going to talk about interventions. We're going to also take some things away because I think sometimes we're doing too much or we're told to do too much.
29:45Before we get into that, though, I do just want to ask, what does mitochondrial dysfunction actually feel like? Because I don't think, I think people hear about mitochondrial dysfunction all the time, but no one's really spoken to them about like, what does it feel like when your mitochondria are not working optimally? It exists on a spectrum. So there's mild symptoms to severe. It's pretty much every chronic disease, nearly every one, science has shown has a mitochondrial dysfunction component to it, meaning cancer, heart disease, autoimmune conditions, any sort of chronic disease. The mitochondria is not working well.
30:25By the time somebody's diagnosed as one of those issues, researchers estimate it's about four to 10 years prior to that diagnosis that there's some cellular dysfunction going on. So that's a decade. And so that didn't happen overnight for most people. It's there underneath the surface. So for the most part, what I would say the telltale signs of the check engine light that wakes people up to, hey, something's off, it's brain fog and fatigue. I would say that's what I see the most of what I hear. It's I'm tired. I'm wired and tired. I'm anxious, but exhausted. I think that neuro-immuno-endocrine axis dysregulation is what I see as far as people's wake-up call.
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31:57What propels you? Propel with Gatorade electrolytes. More than anything, but we know it's far more than that. I mean, the fertility issues oftentimes has a mitochondrial component, diabetes. I went on and on, but it's everything. but I would say the brain and the nervous system, I think I hear the most often. Yeah. I mean, even when you look at endometriosis, the number one symptom that women report is fatigue. And doctors are always like, how do you have fatigue? It's just a period problem. No, it's a full body systemic inflammatory condition. And what does inflammation do? It wreaks havoc on the powerhouse of your cell.
32:35And so, you know, I think so many people listening here, their doctors have dismissed them. A woman goes to the doctor and she says fatigue, and they say, sleep more, drink more water, stop stressing so much, and possibly have you tried losing weight. It's something that really gets brushed off. And I don't think fatigue is a badge of honor. And on the other side of the spectrum, fatigue is not something that anybody should be ignoring. So I want to go into a segment we call protocol playground. And so we've been talking about cellular aging, mitochondria, inflammation, all the things that can move us away from health.
33:08And so I want to move us back towards health. So in the first round, I want to ask you, these are questions that come from our listeners. So this person said, I wake up tomorrow and I want to start taking better care of my cells. Walk me through the first 30 minutes of my morning. I love this. This is a great segment, Dr. Brighton. I think this is super smart and helpful. We look at cellular aging. We have to get a lot done in 30. No, I'm just kidding. There's a lot of amazing things you can do, but I would say a lot of this is based on the concept of adversity mimetics. That's the best science that I would say shows us, starts to allow that cell to recognize what it is again, to decrease that cellular confusion, that cellular noise and static that's going on.
33:55It's what are things that stimulate these rejuvenative pathways, start to downregulate mTOR, start to increase autophagy pathways, start to increase the sirtuins to start to be able to catch up with all the cleanup that they have to do, start to activate AMPK, these NRF2, these pro-antioxidant healing pathways has to do with what stresses out your cell a bit to make it more resilient. What doesn't kill you makes you stronger, the concept of hormesis. The dose makes the poison, the dose also makes the medicine. So fasting is a tool that can be used and we're not talking about aggressive fasting, we're not talking about disordered eating, we're talking about what's right for my body at this point in my health journey.
34:45First 30 minutes, polyphenol rich, something polyphenol rich is not gonna break the fast. So I would say a deep, pungent, bitter green tea. It's not going to break your fast, but it's going to like the, these plant tannins, these polyphenols, EGCG catechins are what researchers call xenohormetic. So they are, the plant went through some stress because it's in the sun. It's having to protect itself. It's maybe growing in some arid area. the more bitter the plant is, specifically the first 30 minutes we're drinking a tea here and we're fasting, the cells from that plant is gonna be communication to our cells to stimulate.
35:30It's saying basically in my mind, the tea is nudging your cells and saying, you know who you are, remember who you are. And it's making your, what made the plant more resilient is gonna make your cells more resilient. So that would be first 30 minutes is something simple, I would say fasting. And then a third thing, some sort of prayer, gratitude practice, which we talked about earlier, lower inflammation markers, lower cellular aging. Whenever somebody has some sort of spiritual practice, you could do that in 30 days, right? That's not too wacky wellness for me to say that, right? Yeah, I think it is something that I always talk about with patients of not letting anyone else control like the first hour of your day.
36:14and that's what going on social media do will do exactly like social media is designed to try to dictate what your day will be like and I think part of that gratitude practice is being able to reset there's a lot of misinformation and often for marketing purposes that tell women that they can't fast and so what you said was a 12 12 this is very normal you close the kitchen at 8 p.m you wake up at 8 a.m maybe maybe you close the kitchen at 6 p.m you wake up at 6 a.m any patient that I have that says I'm unable to do that, I have concerns about their metabolic health because the body is designed to take that 12 hours.
36:51And for everybody listening, this is actually how you were designed to optimally have a good bowel movement in the morning for your microbiome to be moved down into the large intestine to stay there. There's a lot of evidence along with the longevity of what this can do. And as you said, this is not extreme. And you're saying don't break the fast, drink green tea. When they break the fast, what would you recommend they eat? Another thing that I think you could have that would be in the sort of fasting mimicking state that is also xenohormetic is like a pungent olive oil. So the olive oil that have the highest levels of these flavonoids, these polyphenols, these anthocyanins, these plant compounds, it makes it bitter again.
37:33So when in doubt, go bitter. Locally grown, foraged berries, things like this, the dark color, the pigments. these xenohermetic compounds in things like pomegranates and blackberries and blueberries and olive oils and even things like dark chocolate, it's that slight bitterness. It's that tartness. It's that rich pigment that are the compounds that the plant made during times of stress that will then help to cellularly communicate to your cells to become more resilient. So I would break a fast with maybe you could have the olive oil, like a shot of olive oil. What made me think about this is the waking your digestion up.
38:14So you could do sort of an olive oil, extra virgin, pungent olive oil with like a little bit of apple cider vinegar in the morning too in the first 30 minutes. That's going to wake up your digestion, not break your fast. Yes, it's going to stimulate digestion, but it's not going to impact mTOR, that mammalian or mechanistic target of rapamycin, which you want lower during that time of fast. You need it to build muscle, but you don't want it up whenever you're trying to help the cellular debris to be cleaned up, to upregulate autophagy and mitochondrial renewal or mitophagy, you want mTOR to be low.
38:44When you break the FAST, whatever that is for you. So when you might do a 16-8, maybe you're progressed past a 12-12 and you're like, okay, I wanna do a bit more than that. I feel good. Then play around with it. Get creative and see how you feel on any given day and don't hold it so tightly and make it your personality because especially if you have a menstrual cycle, each day is gonna be different. Just show up intuitively for your body at that day. How are you feeling? How did you sleep the night before? Because if you didn't sleep well, maybe you're not going to do a big long fast. It's okay.
39:14So play around with some intuitive fasting. How I would break the fast is honestly, I would do probably waking up, especially the longer fasts, doing something that's gut friendly. Because what's happening, the villi and the gut are a bit blunted. Cortisol is a bit higher whenever you're coming out of fast, especially longer types of fasts, that's how it's supposed to be. That's the hormetic, good stress, cellular, like the sirtuins, the guardian angels of the genome are actually cleaning things up. Autophagy is cleaning things up. So you don't want to really have a bolus of high fruits or something like that right out of the gate, I would say wouldn't be ideal.
39:57If they're eating real food, I'd be fine with it. Look, I don't want to be picky, but if I had to be like specific, I would say maybe sort of a good, hearty, nourishing stew or soup, something that's grounding, nourishing, that's good with filled with clean protein, complex carbohydrates from something like sweet potatoes and something that's nourishing to the gut, like a bone broth. That would be how I would break the fast meal. It's not your typical break fast, but I think it's one of the best things you could do, especially after a longer fast. I just had a curry for breakfast yesterday and I shared it on my Instagram and people are like, you're eating dinner for breakfast.
40:37I'm like, I do this all the time. That's the secret where I'm like, I'm like, I have a big day ahead of me. And like, it's, and also it was, you know, coming back to where I live and acclimating. I went from, you know, 90 degree weather to like 56 degree weather. And I'm like, my body doesn't need like yogurt and granola. My body needs something hearty, warm. I need to like feel like I'm restored and ready for the day. Let me ask you, if someone had to pick one thing to do before 9am that would help their cells, what would you say? A lot of these compounds in these foods, like green tea, there's studies looking at puerh tea, turmeric can act like this.
41:20They call them methyl adaptogens. They basically sort of regulate methylation, which helps to clean up that cellular confusion. Since we didn't, and we talked about prayer and gratitude already, if you're talking about 9am or pushing it past the morning, I would say still be in the fasting state maybe, unless you can't, but you could do, you could break the fast. Let's just say we're breaking the fast with a good soup, and then we are doing a workout. So I would do re-hit. So if you want to say something that's cellular provocative, cellularly provocative, that's adversity mimetic, it's reduced exertional high intensity interval training.
41:56And what's beautiful about this, it's still bio-individual because what's high intensity for one person isn't going to be high intensity for the next person. So the concept of re-hit, which in my mind is kind of like hit training to the next level. It's like level up from hit because it's pulsed, let's just say 20 seconds or so of an all out sprint. You can do this on a bike, you can increase the resistance and it's you're being chased by a tiger for 20 seconds and then you rest for a few minutes and you're just doing two or three rounds of that all outburst of energy either on a bike which is what i do you could do it other ways as well but that is an adversity memetic memetic your cells are upregulated it's enhancing mitochondrial biogenesis your cells making more mitochondria It's been showed over, I think, 16 weeks to increase VO2 max, one of the best longevity markers to show what's your cellular oxygen capacity.
42:56Do you want to be doing that fasted, a re-hit fasted? Probably not. So I'm just thinking you might want to break your fast, then do re-hit. Some people do fine on a fasted workout. I don't want to poo-poo that if that works for you, but just be mindful. On the fly, I'm giving you sort of a high-intensity workout. You don't have to do that. That's great studies to show that zone two exercise. By 9 a.m., maybe do a brisk morning walk. That's probably even better. So getting out, taking your shoes off, walk in the grass, get some grounding. So you're going to sort of habit stack with some grounding, some earthing, if you will, with some zone two exercise.
43:31That is staying in the cardiometabolic zone two. A good way to see if you're in zone two more or less is the talk test. Can you talk and it be doable, but still be not at rest? You're not doing it as intense. But that just shows you that variety is the spice of life. You don't have to do the same thing. You don't have to punish yourself. The re-hit that I mentioned earlier, that sort of aggro hit, you're only supposed to do that two or three times a week every other day. It's nothing. It's a few minutes, 10 minutes max at a pop two or three times a week. The zone two really, and you should be doing this, you mentioned before 9 a.m., morning walks are one of the best ways to enhance metabolic flexibility, which is the cellular rejuvenation at its finest.
44:16There's another question that we had from listeners and it was more of a statement. So they said, if I'm standing in my kitchen and I have to build a plate, what is the best plate I can build for longevity? So I guess we could start with like, how much protein would you have them put on there? Well, it's based on somebody's activity level and age, but I would say one to two palm sizes, depending on where you're at. The goal would be 30 grams a meal. That's going to be 15 to 30, depending on if some people are having lighter protein at certain meals and then maybe having more protein in the other meal.
44:55I want you at least minimum, minimum around 90 grams of protein in a day. But some people stack that 30-30-30. Some people are doing protein sparing and not and keeping mTOR lower in the morning and doing higher, higher protein in the evening. You have to do what works for you. So the totality of the day, every plate could look different. But about one to two palm sizes minimum of some sort of high quality complete protein. So grass fed beef, wild caught fish, something like that. And then lots of good, brightly colored fruits and vegetables, depending on what your body can handle from a digestive standpoint.
45:34So this is kind of the intersection between the longevity health span world and sort of my sort of gut health autoimmune world. Yet sometimes something that may be good for one thing and not the other. So meaning that if there's a lot of colored, colorful plants, but it's causing bloating and digestion issues, we have to look at the proper preparing of it to make it more gut friendly. meet your gut where it's at, don't shame yourself about it. So maybe that's more soups and stews. Maybe that's even cooking this fruits that I mentioned that have all these amazing polyphenols and flavonoids. It's cooking them down to sort of a compote, like inside of a pie without the pie part, which breaks down some of those plant fibers, making it more digestible.
46:14So I mean, I'm coming from the sort of autoimmune gut health world. And sometimes the longevity science isn't there for the people in the autoimmune world. And it's like, oh, that sounds great, My stomach would be wrecked if I had all that raw plant food. So cooking fruits down if you need. Blending it in smoothies can be another way to do it too. And then soups and stews would be another thing that I would consider. So maybe a good compote, berry compote. Maybe asparagus comes to mind. Sulfur rich. Things that are higher in sulforaphane. Maybe sprinkle some broccoli sprouts on it. A good grass-fed steaks.
46:50You get B vitamins, folate, protein, vitamin A. I think that's a solid plate right there, baby. If your ADHD feels different across your cycle, postpartum, or in perimenopause, ADHD in Women explains why hormones can change your brain and what you can do about it. Pre-order now and for a limited time, get the first chapter audio read by me, Dr. Jolene Brighton, for free. Plus a bunch of other bonuses like a free recipe guide and a PMDD workshop. Claim your bonuses at drbrighton.com slash ADHD and women. That's D-R-B-R-I-G-H-T-E-N dot com slash ADHD and women. Propel Fitness Water with Gatorade electrolytes, zero sugar and vitamins.
47:41Propel Hydrates Better Than Water to help you get the most out of your workout and get back to your best self. What propels you? Propel with Gatorade Electrolytes. Then we can go from there. I agree. If somebody could just add five things to their grocery cart this week, what five things could really make a difference? Five things, some sort of high quality protein, long chain omega fatty acids. So some like, well, like pink, think of like the pinkest salmon, these carotenoids that are so important. And these are also very helpful for the cellular repair mechanisms. I would say sulfur-rich plant foods is a great way to activate NRF2, this antioxidant cellular repair pathway.
48:27It activates a lot of these longevity pathways, basically. It also activates glutathione, which is the cellular master antioxidant. broccoli sprouts, asparagus, Brussels sprouts. These are the type of the things that maybe could be beneficial. Cooking them down, if most of these you would cook anyways, but having them pureed. If you have digestive problems, if you have autoimmune problems, meet your gut where it's at. So I'm saying that because the preparation is important for someone that has GI issues. And then I would say some sort of richly colored fruit. So I would say blackberry, blueberry, pomegranate, these flavonoids, they're rich in elagic acid.
49:12And elagic acid helps when your gut consumes elagic acid, will produce your lithin, these postbiotics. That's the products of bacterial fermentation, which produces mitophagy. It upregulates mitophagy or this mitochondrial renewal pathway. So that's five, right? And then tea, there's just so much good studies around the tea compounds. So get a good pungent tea. Maybe it's a puerh tea, oolong tea, black tea, a good solid tea, and then get organic whenever you can for all of these things. But don't stress about it. I think for the vast majority of people, just doing the best they can and giving the rest to God and not stressing about things that are healthy, which isn't good for your health either, is good enough.
49:54You don't have to be perfect to start to nourish yourselves. My question to you would be, what food should we not be eliminating? So there's a lot of static on the internet saying like, this is bad, this is bad, this is bad. Want something that you would say, like if your gut can handle it, if it's good for you, you know, good for your system, this is a food you shouldn't be eliminating. So things like bone broth, as I mentioned earlier with soups and stews, it's great for one person, then can cause a histamine response for the next person. So does that make bone broth bad? It's just there's so much bioindividuality and nuance and context to this.
50:30So yes, you can make a low histamine broth. Yes, you could avoid it for a time. Maybe it's not loving your body back for now. And then, yeah, another food that came to mind is fermented foods. Fermented foods like not just the sourdough piece, but the kimchi's and the kefir's and the kvass's and the kombucha's and the sauerkraut's, wonderful foods for the gut, but are also higher in histamines. So I have to modify nutrition protocols all the time to be low histamine while we're healing the histamine intolerance. So those are some foods that came to mind of, yes, try to bring them in, but they don't work for everybody.
51:05Yeah. And I think to the same point, what I think is important for people to understand as well is loss of oral tolerance is real. And sometimes your problem was never with the food. It was with your restricting of the food. So people get into where they're like, I can't eat any of these things. So they start restricting all of these things. You know, we see this a lot in chronic illness patients who are having digestive issues and they restrict and they restrict and they restrict. And before we know it, nothing feels safe anymore. And part of that can be because you restricted so much and we have to retrain the palate, retrain like, you know, the entire tube so that you can actually be able to tolerate these foods.
51:45And I think that's just important for people to hear and understand because sometimes you can feel like your body is so broken and like something has gone so wrong. But clinicians like us are able to actually help you reintroduce things. And this is, you know, as I'm saying that, you know, some mentioned like medical doctors, you know, and osteopathic doctors, they don't get any nutrition training. This is where I think there shouldn't be a healthcare visit where it's not considered a referral for a dietician, a nutritionist, someone like that. I would even say then I'd love to see the medical paradigm shift to where the intake begins with food and it begins with the nutrition professional and then they go into the intake with the doctor and then there's a collaboration there because I think doctors have a lot to learn and I don't think that they have to be nutrition experts but I think they need to have some respect and reverence for the fact that everything we eat does become us at the cellular level.
52:39I want to ask you so this person said okay I have metabolic instability I don't have diabetes yet but there are signs of insulin resistance. My fasting insulin's been elevated. I just finished dinner. Is there a 10 minute protocol that helps improve what's happening metabolically after that meal? Yeah, well, welcome to the club, right? I mean, it's 93 % of the United States is metabolically unhealthy from mild versions of that to more extreme. So it's only about 7%. I think one of the more latest reports of the United States is metabolically healthy. So you're part of the 93%. But the difference is you know it and you're empowered to do something different.
53:18So yeah, after a meal, I would say walking is one of the best things to do. It can lower postprandial blood sugar pretty significantly, just 10, 15 minute brisk walk. It's back to that zone two exercise. You don't even need to be zone two. I mean, you really don't need to be measuring your cardiometabolic rate per se, but I would say a good, solid, brisk walk, I'd be happy with just moving your body. You could, and we test this on patients, but you could test for yourself on a CGM and watch that blood sugar come down. And it's completely free. other than your time. So yeah, that's something that comes to mind.
53:50I mean, apple cider vinegar, these sort of start back to these sort of bitter things that can stimulate digestion. Olive oil could help digestion too, as well, because a lot of people have this sort of slowed digestion that's impacting their blood sugar longer. I love that you use that word safety. Like so many people on a cellular level feel unsafe, their cells feel unsafe. So the more you can support the parasympathetic, which is like the, it's the resting, digesting, it's improving vagal tone, that largest cranial nerve in the body. So a brisk walk can do it. Getting out in nature, hearing those sounds will help do it.
54:29It's stimulating digestion. That vagus nerve is going to be helpful to do it. Humming can do it. All of these things that are making your body feel safe, resting, digesting, it will help your blood sugar tremendously. And then lean into the fasting, which I mentioned earlier. Someone that's insulin resistant, for this person to ask this question, someone that's insulin resistant but is also a woman tends to, as far as the research is concerned, to do pretty dang good with some appropriately paced fasting. That's some of the best studies we have is improving insulin resistance with some intermittent fasting.
55:04But don't just try to fast your way out of a poor diet. You have to be eating, starting with food first and then building that plate to be building blood sugar stability throughout the day. I love that. I definitely recommend the evening walk and you get your bird song and you get your nature. It can be quite lovely. So we've done breakfast. We've done like, you know, around the 9 a.m. We talked about exercise. We're talking about after dinner. Let's move into bedtime. So what would you say is some of the most optimal things that you can do that hour leading up to bed when it comes to cellular health and aging?
55:40ideally i would want the person to to turn off their screen like get away from the screen a few hours before bed and if you have to and i use the word half very loosely to wear some blue light blocking glasses like i have these ones right here these are the like you can see i don't know if you can see on the camera they're like the um if you're watching this and not listening to this they're uh very like a deep yellow like let's just say pee urine yellow uh for those people that are listening and watching this dehydrated dehydrated pee maybe lots of b vitamin p uh but and then at nighttime you want to wear like the dark like i look like bono from u2 blue colored glasses.
56:30So that's going to really back to that dirty light that we talked about. That's going to help those cellular clocks to know, hey, it's time to wind down. So cortisol has a nice circadian rhythm can start coming down throughout the evening. Melatonin will start coming up. That sleepy time neurotransmitter will convert from serotonin. So you can get proper sleep at night, that REM and deep sleep and heart rate variability. That's where your autophagy, the cellular cleaning pathways are kind of doing their job as you're fasting while you sleep. Really be mindful of your light, like clean up your light hygiene is going to be very important.
57:07I love to tell telehealth patients like a nice, gentle contrast shower, even like do a hot shower and then end on a cool shower. I'm not talking about some agro-hormetic cold plunge at night That's too aggressive. But ending to cool your core temperature is going to be a good idea. I think a good eye mask to block as much light as you can. Blackout curtains can be great. I think a nice frequency sound machine can be great. We talk about nature sounds. These different frequencies of sound, they are naturally in nature. You can mimic through frequency medicine through devices and use devices in a smart, thoughtful way.
57:58I would limit EMFs as much as you can sleep with your phone outside of the room. If you can, turn off your Wi-Fi at night unless you have some sort of medical device where you need your Wi-Fi. My next level would be to, if your bedroom electricity is on its own breaker, to turn off your bedroom electricity at night if it's possible. You have to do what you can. Lean into it. I mean, people can do a Faraday cage and block out EMFs entirely. I think the more you connect with, again, nature to decrease this man-made EMF frequency that we're exposed to all day, whether that's light or EMFs, the better you're going to sleep over time.
58:37So to prepare yourself, prepare this amazing nighttime siesta oasis that you're giving your body through the night. Cellular siesta. So last question, and then you're off the hook of the protocol playground. So I'm a working parent. I have kids. I'm already overwhelmed. What would be like five things that I could do in the day that's going to help my longevity, that's not going to create an exhaustive morning routine, nighttime routine, or it require like extensive meal prep? I think one thing that comes to mind for someone that's busy, that's looking for time is to meal prep. It's to sort of batch make things, freeze things, having things ready at the start of your week.
59:22So you're not bound to the whim of your busy week. I think it's a really, yes, it's a pain. I get it. Not everybody likes to sort of, when I say that, they're like, oh, I don't want to sit in the kitchen for extra time on a Sunday or whatever. But it's for someone that's busy, you have to be set yourself up for success and you can't always control the week. You're not going to control all the aspects of the week. So let's set yourself up for success there. All right. We're going to do a rapid fire. You were saying before, I'm not good at rapid fire. I suck at it, Dr. Biden. We're going to do rapid fire to wrap this up.
59:56And you can just give me like one word answer. Like you don't have to give me very much at all. So if you had to pick sauna or cold plunge, which would it be? Wow. I would say sauna probably for the average person. I like both. I think contrast therapy has its place, but the dose makes the medicine. You don't have to be aggressive with it. But I would say for most people, if I had to pick, I would say sauna. Yeah, I would agree as well. But I also have to share that when I was in Finland, I posted online that I was doing the sauna. I went to Finland just to do saunas and cold plunges. Oh, I love that.
1:00:30I grew up like we would snowboard, then we would do sauna and then you would jump in the snow. And that's like how I grew up. But people were posting online, don't you know, women can't cold plunge. I'm like, someone tell the Finns because these women are like, I get in the Baltic Ocean and I'm like, and then I see these women just swimming laps and I'm like, oh my God, like I aspire. I mean, like the Russian Banya and the Scandinavian Banya. I mean, women do it all the time. They're some of the longest living people. So please, we need a little bit more grit there. All right. Is alcohol compatible with optimal longevity?
1:01:03No. What's something you believed about health 10 years ago that you no longer believe? Wow, that's a good question. And I actually was thinking about this the other day. I don't know if there is anything. Is that bad? I just think I'm pretty middle of the road. And by that - Because we're so basic. I know. We're so basic. We're not these sort of carnivore people that - Because we're like, eat well, exercise, sleep. I don't know if there is. Well, this is what it is. This is more than 10 years ago. This is like 30 years ago. I was like 20, let's just say 25, 30 years ago. I was a vegan for a time.
1:01:40So that definitely, and I talk about that in Ketotarian, but sort of a flexible, cyclical, seasonal approach to eating. I pretty much add that my whole professional and personal life. So I think other than my early 20s, which I thought I knew everything, but I didn't, comes, shocker, I know, guys, It's shocking. People in their early 20s think they know everything. I was a vegetarian, so I'm with you. Yeah. But look, it's like we are not sort of ideologues in the sense of, I mean, you look at some of these carnivore guys. God bless them. Now they're eating more fruit than vegans or eating more honey than Winnie the Pooh.
1:02:13They've changed. But I to me, it's like trends come and go. The tribalism comes and goes. I just am in like what works for you, tribe. And that's why I've kind of, back to your earlier point that you said in passing, but it was an astute point. When people see people for their life and what works and what doesn't work, you kind of are intellectually flexible and can hold it, hold bio-individuality without feeling threatened by it. And it's something that you and I have always been able to do. What do you do every day specifically because you want to be there for your children when you're 80? Hmm.
1:02:54Wow. So I have two kids and I think about this oftentimes too. I would say strength train is one of those things is building like how I'm getting strong now and having good functional movement now is I know that I'm investing in my health down the line. And it's one of the best things you can do for cellular health too, is building lean muscle. It's a glucose sponge. It really is helpful from a cellular health standpoint profoundly. That would be one for sure as lean muscle, preserving lean muscle. I was going to say, Dr. Brighton, something I don't do that I want to confess in front of all the millions of people that listen to your show is that I don't stretch enough.
1:03:34And that's something that I need to do. Flexibility stretching is something that I need to do. I know as we age, I'm in my forties now that I just want to just to confess to everybody right now to hold me accountable, please. I don't stretch enough. My hamstrings are too tight and we need to, from a longevity standpoint, we need to be stretching. I think stretching is the most boring thing in the world. So boring. And so here's my tips for that. One is in the sauna while reading a book, I'll do stretches. And so then I'm just reading and, and my brain's like, we're off. We're doing something else.
1:04:07The second thing is I do mobility instead of stretching. And so I actually do mobility work. Every time I speak on stages, I usually do like a a pretty um intense workout not like a hit but I'm doing my zone two cardio I'm lifting heavy I just recently went to Estonia and spoke the time change I was like I'm not sleeping well I cannot do that type of exercise I instead did a 20 minute mobility workout that is now going to be my routine forever before I go on a stage the way I could move in my body the energy that I had, like everything about it changed. So I would highly recommend mobility over stretching because you are lengthening the muscle while you are also strengthening the joint capsule.
1:04:53And I think that's the biggest thing that we actually end up missing. So yes, flexibility is important, but especially like, you know, whenever I talk with people who have connective tissue disorders, Ehlers-Danlos syndrome, I'm like, I need you to do mobility work. They're like, no, I can't stretch. It'll hurt. And it'll put, you know, dislocate a joint. And I'm like, No, mobility work is strengthening the joint capsule and the muscles that surround that specifically so you don't get injured and at the same time keeping the flexibility of the muscle. So those would be my two tips as somebody who finds stretching to be the most boring thing.
1:05:23Well, I don't do either flexibility, stretching or mobility. So you hold me accountable, Dr. Brighton. I need to do it. I'm going to text you. I'm going to be like, where are you at with that mobility? I was literally like doing the mobility work on my hotel, like bed, like rolling around, doing all this stuff. I'm just a basic loser guy. I'm like, it's like, it's a waste of time. And that's like, no, this is not a waste of time. We need to do it now. This is, this is for our future. Yeah. Well, thank you so much for this conversation. Your new book is out today. So where can people find it? Thank you so much, friend.
1:05:58I appreciate you. I'm so excited for your book too. It's so, your book's amazing. I'm super pumped. But yeah, Heal Your Cells is out now. You can get all the information at drwillcull.com. Just go to books, Heal Your Cells. And it's on Amazon. It's on healyourcells.com. It's on other different places, but support independent bookstores. Yeah, I'm really excited. This is my fifth book and I didn't know I was going to write another book. And this book just called me and I'm so excited for people to read it. Yeah, well, just so everybody knows who's listening, this was just a little taste of what you will find in the book.
1:06:32It is jam packed with so much information that is accessible, non dogmatic, which I think dogma is that I always say dogma equals death in my practice is the fastest way to ensure you don't live long. And I think your book does a really good job of making it accessible to the everyday person. And they don't feel like they have to have a wellness protocol that essentially requires them to quit their full-time job and only focus on their health. Yeah, no, definitely not that. But I thank you for the opportunity and I appreciate you. Yeah. Well, thank you so much. Push your limits. Train with precision.
1:07:09See the results. At Equinox, that's high performance loving. Everything you need to lock in and unlock your potential at Equinox. Start today at equinox.com.
From the publisher
Cellular aging may be happening faster than your chronological age suggests—and in this episode, Dr. Will Cole explains what can accelerate it, what mitochondrial dysfunction can actually feel like, and what may help protect your healthspan; view the full show notes at https://drbrighten.com/podcasts/cellular-aging/. We break down the science of biological age, organ aging, inflammation, metabolic health, circadian rhythms, nutrition, movement, and practical longevity strategies you can actually use.
IN THIS EPISODE
Why people in their 20s, 30s, and 40s may be experiencing accelerated cellular aging
How your heart, brain, kidneys, and other organs can age at different rates
Why brain fog, fatigue, feeling wired-but-tired, and anxiety with exhaustion may be clues worth paying attention to
How inflammation and “cellular confusion” may affect mitochondrial function and aging
Which metabolic, cardiovascular, and inflammatory markers Dr. Cole considers clinically meaningful
How environmental toxins, microplastics, PFAS, stress, trauma, food, and artificial light may influence cellular health
The surprising conversation around nature, bird song, spirituality, community, and longevity
Why light exposure can disrupt more than sleep—your organs have their own cellular clocks
Why fatigue in women, including women with endometriosis, deserves to be taken seriously
How fasting, green tea, polyphenols, and meal timing fit into the longevity conversation
How to build a longevity-supportive plate without following a rigid wellness diet
Why a 10–15 minute walk after dinner may be one of the simplest metabolic tools available
Zone 2, REHIT, strength training, sauna, cold exposure, and mobility—what may actually be worth your time
And how to support healthier aging without turning wellness into a full-time job
ABOUT DR. WILL COLE
Dr. Will Cole is a functional medicine expert, New York Times bestselling author, and an early pioneer in functional medicine telehealth. In this conversation, he shares concepts from his newest book, Heal Your Cells, and explains the clinical lens he uses to think about inflammation, mitochondrial health, metabolic health, and longevity.
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📚 MENTIONED IN THIS EPISODE
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