Feel Sick Before Your Period? It Might Be Menstrual Flu and You Can Fix It | Dr. Jolene Brighten

31 Jul 2025 · 27 min · 12 chapters

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In short

“Period flu” (flu-like symptoms in the luteal phase) and strategies to relieve and prevent it, focusing on hormones, inflammation, histamine, prostaglandins, and diet; also how to track symptoms and advocate with clinicians.

Guest/host

Dr. Jolene Brighten, board-certified in naturopathic endocrinology (hormone doctor), certified menopause specialist, certified sex counselor; background in nutrition science.

Key claims

Symptoms recur monthly after ovulation and resolve when bleeding starts; likely driven by progesterone/estrogen shifts, prostaglandin potency, and histamine (estrogen increases histamine; progesterone helps breakdown). Histamine intolerance may be linked to ADHD/autism and mast-cell activation.

Notable examples

muscle aches, nausea/vomiting, cramps, low-grade fever/chills, headaches/migraines, dizziness, constipation/diarrhea, insomnia, extreme fatigue; advice includes fish oil/wild salmon, ginger tea, avoiding alcohol/processed foods, omega-3 vs omega-6 changes, low-histamine foods short-term, DAO support (quercetin/foods), and possible OTC antihistamines only with doctor/pharmacist guidance.

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

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Understanding Menstrual Flu

0:45 to 2:55

Discussion on the symptoms and experiences of menstrual flu.

“Have you ever felt like you were coming down with the flu before your period?”

Immediate Relief Strategies

2:55 to 3:46

Practical tips for alleviating menstrual flu symptoms quickly.

“Now, if you're dealing with the period flu right now, I want to give you three things that you can do today to feel better fast.”

Defining the Period Flu

3:46 to 5:57

Exploration of what period flu is and its symptoms.

“a set of flu-like symptoms that show up in the second half of your cycle, so post-ovulation, but before your period starts.”

Causes of Period Flu

5:57 to 8:06

Analysis of hormonal changes and their impact on period flu symptoms.

“So what causes the period flu is probably what you're wondering right now.”

Prostaglandins and Diet

8:06 to 10:13

Discussion on how diet affects prostaglandins and menstrual symptoms.

“Prostaglandins are hormone-like compounds that drive inflammation.”

Histamine's Role in Menstrual Health

10:13 to 12:13

Insight into how histamine interacts with menstrual cycles and symptoms.

“We got to talk about this because it's a major but often overlooked factor in the period flu.”

Supporting Gut Health and Liver Function

13:16 to 14:00

Strategies to improve gut health and liver support related to menstrual flu.

“That's D-R-B-R-I-G-H-T-E-N dot com slash ADHD and women.”

Understanding Period Flu and Self-Advocacy

14:00 to 18:45

Learn how to recognize and advocate for symptoms of period flu.

“That can help with histamine-related period flu symptoms.”

Tracking Your Cycle for Better Health

18:45 to 20:19

Discover how tracking your menstrual cycle can reveal health insights.

“Now there's oodles of studies saying HPA dysregulation, and it's becoming more acceptable.”

Dietary Strategies for Managing Symptoms

20:19 to 24:59

Explore dietary changes that can help manage symptoms related to period flu.

“Day one is the first day of your period.”
Show all 12 chapters

Medication Considerations and Consultations

24:59 to 26:08

Understand the importance of consulting a doctor about medications.

“And if you are on medications and you're like, I can't get in to see my provider for like six months because I know that's reality for some people, go to your pharmacist.”

Medication Considerations and Consultations

26:27 to 26:51

Understand the importance of consulting a doctor about medications.

“Back to School Season is officially here, and DeeDee's has everything on your list.”
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Transcript

Automatic transcript. May contain errors.

0:00From athletic stuff like a full court pickup game, swish, to athletic stuff like a half mile stroll. Get those steps in. Head to Sierra or Sierra.com for the brands you want at the prices that let you do it all. From athletic to athletic, Sierra's got it. Hey friends, Olivia from Oli. Between new routines and the ultimate group project known as parenting, you need science-backed solutions that work with your life. That's where Oli comes in. Start your mornings off right with Maltese made to support nutrition and immune health. Choose from our lineup of gut-supporting probiotics. And we've got occasional sleep support to help the whole fan chase their big dreams.

0:34Head back to class with the number one gummy supplement brand. Stock up on ollie.com today. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Have you ever felt like you were coming down with the flu before your period? Like the achy, exhaustion, maybe a little bit feverish feeling, only to have those symptoms entirely disappear before your period starts? yeah, this has happened to me too, and I actually struggled with symptoms of the period flu off and on for years. So if this sounds familiar, you might be dealing with the period flu too, and while it's not an official diagnosis, it's a very real experience.

1:13And for many women struggling with it, it is something that they get gaslit about. So today in the Dr. Brighton show, we are going to break down the period flu and what you can do about it. Hi, I'm Dr. Jolene Brighton. I'm board certified in naturopathic endocrinology. That means I'm a hormone doctor. I'm also a certified menopause specialist and a certified sex counselor. And if you don't know, my background is in nutrition science, so we'll be talking a lot of food is medicine to help with the period flu and PMS struggles that can come up. Now, in today's episode, we're going to cover what the period flu is and why it happens, the role of your hormones, inflammation, histamine, because yes, histamine plays a big part in this.

1:58And I'm going to give you the strategies to relieve symptoms and even prevent the period flu altogether. We also have to talk about how certain hormone-like chemicals called prostaglandins are influenced by omega fatty acids and how changing your diet can influence those to reduce symptoms. And then I need you to track your period, friends. I need you to track your whole cycle. We'll be talking about why tracking your symptoms is critical and how to advocate for yourself if your doctor dismisses you. So if you're tired of feeling like you have the flu every single month, this is the episode for you.

2:37Please, please, please consider leaving me a review or sharing this with a friend. Reviews help so, so much. And big thank you to my sponsors because without them, I wouldn't be able to make all of this content for you. All right, with that said, let's dive on in. Now, if you're dealing with the period flu right now, I want to give you three things that you can do today to feel better fast. So the first thing is take one gram of fish oil or a thousand milligrams or eat some wild-caught salmon to help lower prostaglandins. Number two is drink ginger tea and that can help reduce nausea, but it also can help with inflammation as well.

3:19It's really great for the gut. Number three is don't drink alcohol, cocktail shots, a glass of wine, whatever it is. Don't drink alcohol and avoid processed food for the next three days to help reduce the histamine flare-ups that you might be experiencing right now. Okay, so I want to get that in so that you have some tips that you can employ right now, but we need to talk about like what is the period flu. The period flu refers to a set of flu-like symptoms that show up in the second half of your cycle, so post-ovulation, but before your period starts. So let's do a quick refresher of your cycle.

4:00Day one, first day that you bleed. That's your period to ovulation is the follicular phase. Estrogen is going up, up, up, up, up, and it's peaking right before ovulation. Your uterine lining getting nice and thick and your body is preparing for ovulation. Ovulation then happens and that is estrogen spiking. So estrogen is going to go really high, spike, tell the brain, okay, it's time. The egg's ready. The brain releases luteinizing hormone, and that triggers the release of the egg. If you read Is This Normal, where I do also talk about the period flu, I use the like, you know, release the kraken voice of like, release the egg!

4:40Now, once you release the egg, you enter into the luteal phase. Progesterone should be going up. That's supporting the possibility of a pregnancy, and so progesterone is being produced by the corpus luteum, a temporary endocrine structure that's left behind as a result of ovulation. It's going up, up, up, but sometimes it doesn't. This is when many women experience PMS, but also the period flu can happen. And the period flu symptoms that can include things like muscle aches, nausea, vomiting, cramps, abdominal pain, low-grade fever. So not a fever to like, you know, call the doctor about, but a little bit of a fever, chills, headaches, migraines, dizziness, lightheadedness, constipation and diarrhea can come with this.

5:29You might feel like you can't sleep. You might have extreme fatigue or exhaustion. And your joints may also feel achy. The key thing to note is that these symptoms happen at the same time every single month. And they go away when your period starts. So that's why you need to track your symptoms. You need to be tracking this because you might actually be getting sick. You could be sick. But if it's happening month over month, friend, that's most likely the period flu. So what causes the period flu is probably what you're wondering right now. The exact cause isn't well studied. Shocking, I know, right?

6:06Because we just like don't study women's health because why would that matter at all? I digress. Anyhow, here's what we do know, the theories that we have. So the hormonal fluctuations I was talking about in that quick mini crash course on your cycle, your hormones are shifting dramatically during that luteal phase. Progesterone rises and then it drops sharply before your period. So that can trigger fatigue, mood changes, sleep disturbance. Estrogen also declines right before your period. And since estrogen supports serotonin, its drop can leave you feeling off like you're sad and also coming down with something.

6:45But what often happens is you don't make enough progesterone, estrogen's unchallenged, then estrogen goes and interplays with histamine, and it can cause you to feel irritable and cranky and achy. We're going to talk more about histamine, but it's usually an issue with not getting your progesterone up. So here's a few things you can do. Number one is manage your blood sugar. Protein, fat, fiber, every single meal, every single day. Keep your blood sugar stable. support progesterone through decreasing stress and regulating your blood sugar. Super important. Vitex. You know I'm a fan of this herb.

7:23I talk about this herb all the time. It can help boost your progesterone naturally. Usually we're using about 200 milligrams a day throughout the cycle. Magnesium also helps with regulating your hormones and it can help with reducing inflammation. It can help with prostaglandins that we're going to talk about soon. 300 milligrams is usually a sweet spot of magnesium glycinate. Limit alcohol and caffeine during this time because alcohol can raise histamine and caffeine can make anxiety and sleep issues worse. That doesn't mean you can't have any coffee. Just like, friend, don't be passing three cups a day, okay?

8:00Now, prostaglandins and inflammation. I mentioned those briefly, but we got to put together this little puzzle piece for you. Prostaglandins are hormone-like compounds that drive inflammation. They're not all a bad thing, okay? Because prostaglandins can cause uterine contractions, which helps shed your uterine lining, that's your period, and help with you having a baby. But when they're too potent, they can contribute to really severe cramps, headaches, nausea, and even fever. They're also responsible for period poops. And yes, that's a thing. They make your digestive system more active. They're stimulating your intestines as well, leading to diarrhea in some women.

8:41But here's some things people don't always know. Prostaglandins are made from omega fatty acids. So there's different types of prostaglandins and there's different potencies of prostaglandins. And they can be pro-inflammatory and anti-inflammatory depending on the fatty acids they come from. So omega-3 fatty acids, those are the anti-inflammatory ones found in wild-caught salmon, flax seeds, walnuts. These help with you having effective prostaglandins causing your period, right? But not so much that they cause period pain. So we need prostaglandins to contract our uterus, to shed the uterine lining, but we don't want them being super potent.

9:25And how do we get super potent ones? We have a diet rich in omega-6 fatty acids. And omega-6 fatty acids are found in vegetable oils, seed oils like soybean, corn, sunflower, fried foods. And these make more potent prostaglandins. This is why a diet rich and ultra processed food is a fast track to horrible periods that you hate. So a quick fix if you're struggling with the period flu is to increase omega-3s and reduce processed foods, reducing omega-6 oils. So you can try fish oil supplements, one to two grams daily. You can add more wild-caught salmon. You can eat chia seeds. You can have fresh ground flax seeds in your diet.

10:08These things will help to shift the omega-3 profile of your diet. Now I want to shift gears to histamine and the period flu. We got to talk about this because it's a major but often overlooked factor in the period flu. So what is histamine? Histamine is a compound that's involved in the immune system, and it skyrockets when estrogen is high. It's also involved in your mood as well. And we can see there's a connection between histamine and PMDD as well. I'll put a link in the show notes about that. Now, estrogen triggers histamine release, while progesterone helps with its breakdown. So if you have something like estrogen excess or an imbalance of estrogen progesterone, if you have histamine intolerance, you might have headaches and migraines, nausea, sinus congestion, feeling dizzy, anxious, heart palpitations.

11:04It can show up in a lot of ways. And if this is resonating with you and you're like, say more about histamine, then friend, we got to talk about being neurodivergent. So both ADHD and autism have been linked to mast cell activation syndrome, histamine intolerance, histamine problems in general. This means that women with ADHD or autism may be more prone to histamine-related symptoms, especially when estrogen fluctuates in the menstrual cycle, so PMDD and period flu may be upon you. So why does this happen? Okay, histamine plays a role in neurotransmitter regulation, so what's happening in the brain, including dopamine, which is already dysregulated in ADHD.

11:47Many autistic women have heightened immune responses leading to increased mass cell activity and more histamine release. ADHD is also associated with dopamine dysregulation and histamine influences dopamine signaling in the brain. So I will put some links in the show notes to ADHD and PMDD and this whole histamine connection if you want to read up on it. If you want me to do an episode about it, just leave me a comment. Let me know. Now let's talk about how to reduce histamine-triggered period flu. Firstly, you may need to eat low histamine foods, so focusing on fresh meats, leafy greens, apples, pears, coconut products, and avoid high histamine foods like aged cheese, processed meats, alcohol, fermented foods, and sometimes chocolate.

12:38I hate that one. Just the week before your period or the time that you've identified that you deal with the period flu. If your ADHD feels different across your cycle, postpartum, or in perimenopause, ADHD in Women explains why hormones can change your brain and what you can do about it. Pre-order now and for a limited time, get the first chapter audio read by me, Dr. Jolene Brighton, for free. Plus a bunch of other bonuses like a free recipe guide and a PMDD workshop. Claim your bonuses at drbrighton.com slash ADHD and women. That's D-R-B-R-I-G-H-T-E-N dot com slash ADHD and women. we also need to support the dao enzyme which is the enzyme that breaks down histamine and you can do that by eating more beef 6 found in turkey bananas chickpeas or supplementing at 25 to 50 milligrams a day quercetin which is found in onions apples capers and nettle leaf tea that can help stabilize the mast cells so they don't dump all this histamine you can also try histamine blocker.

13:52So if your enzyme is struggling, supplements and diet aren't enough. You may want to try something like Zyrtec or Claritin. That can help with histamine-related period flu symptoms. But you need to talk to your doctor. Okay? So with all of this advice right here, remember I am a doctor but I'm not your doctor. So you need to check in with your doctor. We're not in doctor-patient relationships. So just want to be certain of what's right for you. Now we also have to talk about gut health and liver support. So since histamine and hormone balance are tied to gut health and detox pathways, adding in some quick love to those organs can be super powerful.

14:34So eating cruciferous vegetables, broccoli, Brussels sprouts to help the liver break down excess estrogen, considering maybe broccoli sprouts, if you are someone who's struggling with histamine issues, you're trying to avoid histamine foods. You can support your gut with probiotics and fiber to prevent estrogen from being reactivated and put back into circulation. And you could try things like dandelion or burdock root tea to help with your liver's detox pathways. Now I want you to keep in mind that women with histamine intolerance often have gut issues like irritable bowel syndrome, SIBO, leaky gut, you have to address those.

15:16And so it's very important that if you think you have gut issues that you look into those. And I will also link to the quick IBS endometriosis episode that I did so that you can see why IBS is sometimes a mistake to diagnose someone with. Now, many women are getting dismissed by doctors when they bring up the symptoms and they say something like period flu. And so I want to talk to you a little bit about like how can you advocate for yourself? If your symptoms are severe enough to make you miss work or school every month, don't let anyone tell you it's just normal PMS. If your doctor isn't taking you seriously, ask for hormone testing, histamine intolerance evaluation, even a referral to a naturopathic or functional medicine doctor.

16:04Because the reality is that you deserve to feel good all month long. Now, if your doctor is dismissing you, you can say something like, I have these flu-like symptoms at the same time of my cycle every single month. I'd like to investigate the potential causes, including what hormones or histamine issues could be involved, and then let them know how it's impacting your activities of daily living, how it's interfering with your life. So I know that can be difficult. And even though the period flu isn't widely accepted, it's very real. And if you're feeling sick every month before your period, it's definitely time that you listen to your body.

16:49And hopefully you are able to get your doctor to listen to you as well. And I want to remind you that the period flu is common, but that doesn't mean it's normal. And these symptoms are your body's way of talking to you. They're really giving you a clue of what is going on and helping you, you know, navigate like what, you know, what these symptoms are saying to you. You know, that can be as easy as tracking your cycle. So track your cycle, track your symptoms, use something like Natural Cycles, which is a really easy app to leverage. I want to recap with reminding you that you can shift your diet.

17:26So increasing omega-3 fatty acids, lowering histamine foods to reduce inflammation can help. Advocate for yourself with your doctor, even if they dismiss you. Ask for testing, ask for evaluation, and try quick relief tips like, you know, the magnesium we talked about, the ginger tea. It's also important to stay hydrated and making sure, you know, when you're staying hydrated that you are drinking enough water throughout the day to support those detox pathways. So if you found this episode helpful, I would hope that you would share it with a friend or anyone you think needs to hear it. And if you've ever experienced the period flu, DM me on Instagram or comment on my latest post.

18:16I want to hear your story. I'd like us to start breaking the silence of this and help more women take control of their health. Because this is something that women are struggling with month after month, and they're getting absolutely dismissed and unheard. And much like, you know, PMDD used to be something that was dismissed as just bad PMS. We see adrenal fatigue used to be the term that patients used. Now there's oodles of studies saying HPA dysregulation, and it's becoming more acceptable. Leaky gut was a term that patients used. I brought it up and I said it in this episode, and there's still doctors who will dismiss that.

19:00And yet intestinal hyperpermeability is validated in the research. So while we don't have a ton of research on period flu, I do expect in the future we are going to see both medicine and science finally validate what women have been saying forever, which is like the reality of what happens, right? Whenever there's studies that come out about women's health and they're like, oh, this is real. And it's like, we could have told you that. In fact, we did tell you that. You just chose not to listen. So medical gaslighting is real. Research in medicine is really not where we need it to be to help us right now.

19:43And it is my hope, and I do believe we are going to get more information on this in the future. However, I think that what we need to do now is we need to honor what is true for the individual. We need to believe women about their bodies. and we need to start formulating our best ideas and offering simple solutions that people can manage in their life. Now, the last thing I wanna talk about is I said it's important to track your cycle. Okay, if you are tracking your cycle or if you're not tracking your cycle, I should say, and you're like, okay, how do I even start this? Day one is the first day of your period.

20:23We need to know how many days does your period last and how heavy is it throughout the cycle. By the way, I outline all of this. My book, Is This Normal? And I take you through what's normal and what's not normal about periods and hormones and everything really about being a woman and living in your body. So we want to know quality, consistency of the period, how long it lasts, how much pain there is, are there clots, how big are those clots? We want to quantify as much data as possible. We want to know when your period starts, And then the next period starts, how much time is in between there?

21:00So how long is your cycle? Then we want to understand things like what happens around ovulation. There are, I go through the six signs of ovulation in my book, but one of the key things is that we will see a basal body temperature spike and we see lots of fertile cervical mucus that precedes ovulation. That's a sign that estrogen is up. So we want to know what's going on around that time. If you're someone who struggles with histamine issues, this can be a clue and an insight. Because if you don't feel good around ovulation, that's when estrogen is super high. As I told you, estrogen is going to be up and it will cause histamine to go up.

21:41It also will slow the enzyme that breaks down histamine. So you could be dealing with histamine problems. Also, if you have endometriosis, you might be having pain around ovulation. That's another important sign to track. Then we want to know what happens after that. If your mood tanks within a few days post-ovulation, we might be looking at PMDD. If you are finding that seven days post-ovulation, you're like, no, I'm still feeling pretty good, but once I get within like three to five days of my period, now I'm feeling achy. Now I'm feeling that feverish flu-like kind of symptoms. that can point towards the period flu.

22:22Why is that? It is often, as I said before, not enough progesterone relative to estrogen. So we don't make enough progesterone and estrogen just gets to come out and play, which might be great sometimes for dopamine and for serotonin, but it's not so great if you're dealing with histamine issues during that time. So you need to track those symptoms and understand what's going on. When you identify when those symptoms are going on, three days before that, that's when I would say start a lower histamine diet. Make sure that you're getting in, you know, some of the things we talked about with the DAO enzyme clearance in supporting that.

23:02Making sure that you have those things on board. That way you can cut it off at the pass. So really important to identify when those symptoms are and then to act early. I am not a fan, by the way, of a low histamine diet for life. I think it's a horrible way to have to live. No leftovers ever. Like, I ain't got time for that. And as I told you, like, histamine is very closely associated to ADHD and autism. And like, to my ADHD ladies out there, like, like meal planning and prepping and like having to, like all of that. And then for autism, the change in the routine, like that can cause more stress, which then causes problems for your progesterone.

23:43So if we're going to use a low histamine diet, I'm trying to dial in the window of when is it absolutely necessary to utilize that. And if we identify that like, okay, this, you know, five days before my period, I have the period flu symptoms coming on, but I can't change my diet. That's too much for me. That's fair. Sometimes what we do in my office is we start Claritin doing 10 milligrams twice a day, the day before we would expect the period flu symptoms to onset, so 24 hours before, and then just through that phase. That's a short-term strategy while we work on some of the bigger underlying issues, like what's going on in your gut.

24:28Again, while I mentioned a medication here, I have to remind you, you must talk to your doctor. Even though this is over-the-counter, these medications, medications, well, it's better than Benadryl. I will say that. The Neuogen is better than Benadryl. You still have to talk to your doctor. You might be on a medication that this will interact with. You might have a medical condition that this would be problematic for. You might decide that you're just going to stay on this indefinitely, and then we might have cognitive changes in the future. We don't want any of that. So talk to your provider.

25:02Make sure that this is safe for you. And if you are on medications and you're like, I can't get in to see my provider for like six months because I know that's reality for some people, go to your pharmacist. Talk to them about the medications you're on. Talk to them about like, I would like to use Claritin. See what they have to say. They will advise you. Your pharmacist is such an ally when it comes to managing the medications that you're on. All right. I hope that this has been very helpful for you. I do have a free hormone balancing meal plan. You can find that in the show notes or at drbrighton.com slash hormone kit.

25:38And it does talk about other strategies to boost your progesterone as well. The hormone balancing meal plan is not designed to be low histamine. It is, however, gluten-free and dairy-free because I know some people have issues with that. And it is designed to support your liver detox pathways, your gut in moving out the metabolites of estrogen and the estrogen you no longer need. So again, you can grab that at drbrighton.com slash hormone kit. If you enjoyed this episode, please leave me a review. I would really appreciate that. If you have left a review, thank you. I read them all. I really appreciate it.

26:17And as always, you drive the conversation. So let me know what you want to hear next. This episode is brought to you by DeeDee's Discounts. Back to School Season is officially here, and DeeDee's has everything on your list. I'm talking bold styles, cool kicks, backpacks, and even dorm room essentials. All the prices that won't hurt your wallet. So don't sleep on DeeDee's. Whether you've got a second grader or a sophomore, DeeDee's has your whole family covered. Find a DeeDee's discount store near you and go check it out today. Hi, Ryan Reynolds here for Mint Mobile. Are you looking for a beach read this summer?

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From the publisher

If you feel achy, foggy, nauseous, or feverish before your period—only to have it all vanish once your bleed begins—you’re not alone. You may be experiencing menstrual flu, a cluster of flu-like symptoms that affect countless women during the luteal phase, yet remains mostly unrecognized by conventional medicine. In this episode of The Dr. Brighten Show, we break the silence around period flu symptoms, explain the science behind why they happen, and give you the tools to feel better—fast.

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Quick IBS & Endometriosis Episode: https://podcasts.apple.com/us/podcast/the-dr-brighten-show/id1786362161?i=1000700150293

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Vitex (chaste tree berry, 200 mg/day) View my Balance Women’s Hormone Support https://drbrightenessentials.com/products/balance?selling_plan=995295266

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