Peptides for Hair Loss & Skin Aging Reversal: OneSkin Review

33:42Head back to class with the number one gummy supplement brand. Stock up on OLLI.com today. These statements have not been evaluated by the Food and Drug Administration. this product is not intended to diagnose, treat, cure, or prevent any disease. In this study, the OS1 peptide that was being applied to their skin and to their body? Yes. I mean, their face and their whole body, right? Oh, sorry. That's what I meant. I was pointing to my face and realized like, not everybody's on YouTube with us. Yeah. So their face and then their full body. And that's tremendously impactful. I actually haven't heard of any research where you apply a skincare product and you see a reduction in inflammatory cytokines.

34:24And that also, as we were talking about perimenopause and menopause before, which is when we see such a rapid change in the skin, we see the rise in senescent cells, we see the inflammation, we also see that a large number of women suffer from new onset anxiety, depression, and even thoughts of self-harming. And to me, I'm now, now as a clinician, I'm like, okay, hold up. Like we're, we're looking at gut health. We're looking at their diet, right? We're, we're looking at exercise. We're looking at all these things, but it hadn't occurred to me until this moment, until hearing about this study that we should also be looking at their skin because right.

35:03We're always like, get outside, get your vitamin D, like get your sunshine, but also like wear your sunscreen and not really thinking about leveraging a peptide for immune system modulation. I'm having like kind of a mind blown moment of like, this is really a interesting frontier in terms of having, you know, we talk a lot about holistic medicine, but if we're leaving the skin out of this conversation, it's not really that holistic. Yeah, a hundred percent. And it's one of our goals at OneScan to really include the skin in that conversation because it is one important organ for overall health and one that we neglect a lot of times.

35:47And the skin is a reflection of our internal health, but also sends signal to our internal body. And so it's like a two-way approach that I think we all need to be aware of. And on top of like the implication in our health, the other piece that happens as we age and we ignore like the 97 % of our skin, which is our body, is the appearance of like crepeness and very thin skin, right? And it's like with menopause, you see an increase, you know, significant increase in craveness because of that collagen decline. And that, you know, body treatment can help with that, can help like thicken the epidermal layer of the skin, can help like combating the senescent cells, can help your skin to produce more collagen again.

36:40So even like the improvement in the appearance, the texture, it's really, really impressive. Like what we have seen from our communities and from our clinical studies in recovery that, you know, strong, resilient aspect of our skin that we have right now. But we take it for granted. And then, you know, later in life, we're going to see, wow, why I didn't, you know, treat more my arms, my legs. And even like later in life, they can start like to bruise really easily, to, you know, tear really easily. So it's one area that we also like to bring awareness that we should, you know, treat and invest early on because eventually that will impact our lives in so many ways.

37:25Yeah. And I especially think, you know, as you're talking about this, I think about my family members who are in their 70s. 70s. And there was a situation in our car. We have a little chihuahua. And our son was like, oh, let me just throw the dog on grandma's lap real quick. And the dog started scrambling. And I freaked out and had to explain to my son, once somebody's in their 70s, they can't have dog nails scratching on their skin. Their skin is very fragile. And as you're saying all of this, time, like, I need to ship them some of this peptide. I need to get them this OS1 peptide for my anxiety's sake because I get so worried about that.

38:06And it's something that that generation has certainly said to me, my family members, patients, you know, people I've been in contact with have said to me exactly what you just said. I didn't worry about my skin until it was too late. And I think we have a lot more awareness now. We have a lot more technology with protecting our skin. But it's good to hear that there's a product that can help because I think sometimes when we talk about aging, some things are like, well, you should have known better in your 20s. Like, how many of us knew better in our 20s, right? And then it's like, there's nothing you can do about it.

38:39So having something that you can actually come in and intervene with, I think is fantastic. You mentioned this concept of basically intrinsic and extrinsic aging. So you talked about like, you know, our inner body is a reflection of our skin, but also our skin is affecting our inner body. Can you go into a little more detail around that? Yeah, definitely. So what we call intrinsic aging for the skin more specifically is basically the natural aging process. Your cells are dividing, eventually they'll get old and either they will die or they'll become zombie or senescent, and that's mainly genetic driven.

39:20And that accounts for about 10 % of how we age. Only 10? About 10%. I love this. This is amazing. Okay, keep going. Yeah, the other 90 % of how your skin ages, it's mainly caused by extrinsic factors, which are the UV exposure, our life, you know, our habits, or if you smoke, blue light, pollution, your diet, if you exercise. eyes and so mostly for the skin and I think you know in our inner body this ratio can vary a little bit more but in the skin because obviously UV exposure is one of the key drivers of skin aging this extrinsic factor you know is even more important so we needed to be even more aware of obviously you know sun exposure but also blue light and also pollution and how we're cleansing in your skin, but obviously, you know, our diet, our exercise, our sleep will also affect.

40:26And it's good to know that because there's so much that we can do, right? Almost like 90 % is in our control of how our skin can age. And there are so many things that we can do today. And obviously you talk a lot about them. We can talk more about our skin as well in terms of, you know, sun protection. I'm also a fan of, you know, having the natural light early morning, but I also know, you know, long exposure, sun will cause sun damage and that's how they become zombies. So we know the higher the exposure of UV damage, the more senescent, the more zombie cells your skin will have. And also we know the more zombie cells you have, the more, you know, fine lines, wrinkles, loss of, you know, firmness, uneven tone, dark spots, sun spots we'll have.

41:20So I think we have in our hands like the power of like preventing a lot of that. I want to go deeper on this sun exposure, but you said blue light and I'm sitting here right now in front of a laptop and so are you. How is blue light aging our skin? Yeah, so blue light is basically causing a lot of oxidative stress, producing more free radicals. These free radicals are basically molecules that are going to cause damage in our proteins, in our DNAs. And so there are two ways that you can prevent that. One is through antioxidants that will neutralize the free radicals and prevent them from causing damage.

42:03and also sunscreens, like in our case that we use, like zinc oxide, the mineral sunscreens, they can also protect against blue light. So if you're wearing sunscreen right now, it doesn't mean that you are like close to a window necessarily, but if you are in front of the screen, your sunscreen, in our case at least, we made sure that it also contains ingredients that will protect against blue light. I love that. That is seriously so good to hear. But you said antioxidants. What antioxidants should we be looking for to apply to our skin to protect it from oxidative stress? So there are many antioxidants out there.

42:45I think one important thing to know is the stability of the antioxidants. So vitamin C is a classic. It's a powerful one if it's stable and active. it's really easy that your vitamin C will oxidize. So if you are using a product and it's becoming brown, you know that's oxidizing that the vitamin C is probably not active anymore. So today there are forms of vitamin C that are more stable. We do use a stable form of vitamin C in our sunscreen. So other antioxidants are like green tea, acai extract. there are other plant extracts that are you know can be super powerful in antioxidant on our body lotion we have sulforaphane that's another very powerful antioxidant i'm always using that internally um telling people to eat broccoli sprouts but i mean it's so powerful in the research in terms of when we look at cancer formation and you look at sulforaphane and eating your cruciferous vegetables.

43:55So I'm actually excited. I want to hear more. Tell me more about that molecule for your skin. Yeah, basically, it's this really powerful antioxidant that helps, again, fighting these free radicals and can help your skin to, again, be more effective in fighting that damage. And as you point out, there are studies showing that it can fight the cancer cells. But in the skin will help like your skin repairing damage more efficiently. So if you're able to repair damage, your skin will not accumulate those zombie cells. That zombie cells comes from a lot of damage. And these powerful antioxidants can help with that.

44:38What form of vitamin C should people be looking for? I don't have the name right now, but I can send to you. and I will send, we can add on the notes of the episode, but there is this stable form of vitamin C that I know that we should look for it because it's not going to oxidize and you know that it's going to be, you know, active long-term. Okay. So I want to circle back to the UV conversation because we know, right, that there's certain times that we want to stay out of the sun, but then you said you still want to get your morning sunlight, which we know is great for cortisol. So what are kind of the general guidelines for maintaining healthy skin when it comes to sun exposure?

45:29I think the general that I, you know, take and I recommend that I'm not a dermatologist or a physician, I'm a PhD, but based on my studies and my, you know, obviously my research in the field is that you want to avoid, first rule obviously is like avoid sunburn, right? And so sunburn, we know that is definitely correlated with skin cancer and that we want to avoid at all costs. I think that, you know, early 15 minutes, like sun exposure in the morning, again, depends where you live, because even in the morning, depending, it could be already really hot. So usually the recommendation is a UV index under three.

46:19But I know that some places, you morning you can already be above three. But I would say, you know, avoid the sunburn, 15 minutes light in the morning. And then I apply my sunscreen every day. I usually replace my foundation with the sunscreen because we have this tinted one. And to me, like if I can have like a tinted sunscreen that is performing like my foundation, it doesn't give you a lot of coverage, but just like, you know, even your tone a little bit. I know that's protecting my skin. It's like a very nice texture. Like I don't feel that I have sunscreen in my face. So I do that. And so I'm protected again for blue light, for sun, you know, for driving.

47:06I think that's the other, you know, part that sometimes we forget on our hands as well because we're driving. But I would say, and I enjoy a lot, you know, outdoors activity, but I'm constantly like reapplying sunscreen in a way that I don't get sunburn, but I get a little tan. And I think that's fine because your melanin is protecting you against the UV damage as long as you're not like getting sunburn. So that's my philosophy. I know that again, people will have different opinions, but I'm more like in that middle ground that I still enjoy life outdoors. I love that you're saying that, though.

47:48I still enjoy life because sometimes I have friends who are dermatologists and they're like, yeah, right. Don't go out in the sun. You should never be out there. And I appreciate what you're saying about your hands, too. So I garden. I do love being outside. I also love to snorkel. And when I go out snorkeling for hours, I will wear a shirt that's a UV protection because I'm not going back in to if I find, you know, really cool puffer fish, I'm hanging out, not going back to reapply sunscreen. But I've always done like whatever I do to my face, my neck, my chest, do it to the back of your hands as well.

48:25And because you're going to go out and you're going to live life. And I really appreciate that message because sometimes, you know, and let me just say to the dermatologist credit, they see a lot of skin cancer. So if you're just seeing skin cancer day in and day out, you're going to have a different perspective about things. But we can't lose the plot in terms of what are we here for. It's to live a full life.

49:13to severe eczema, also called atopic dermatitis, that is not well controlled with prescription therapies used on the skin or topicals or who cannot use topical therapies. EBCLIS can be used with or without topical corticosteroids. Don't use if you are allergic to EBCLIS. Allergic reactions can occur that can be severe. Eye problems can occur. Tell your doctor if you have new or worsening eye problems. You should not receive a live vaccine when treated with EBCLIS. Before starting EBCLIS, tell your doctor if you have a parasitic infection. Paid partnership with Lilly. Respect your time. Ask your doctor about Epclus and visit epclus.com or call 1-800-LILY-RX or 1-800-545-5979.

49:49Yeah. And I think that's going to bring you joy. That's going to decrease your cortisol level. That's going to reduce inflammation. So I think there is like so much of these other benefits that we're not taking account. And it's also helping your internal health in so many ways. Absolutely. So we talked about, you know, the sun exposure. What about people listening right now that maybe they were the baby oil era? You know those people, right? I remember my mom putting baby oil on and going out into the sun. Their skin now, they've suffered skin damage. Are there things that they can be doing now?

50:29Like do some of these antioxidants, are they going to offer protection? Are there ways to reverse that? Yeah, 100%. I think the beauty of, you know, what science has shown us is that aging is a malleable process. It can be reversible. And so all of that, what we talked today, you know, your diet, your antioxidants, the peptide, even the retinol at, you know, the right dose and the sunscreen will help like, you know, reverse part of that process. obviously it's going to be a gradual process. It's going to take months and years, but it is possible with the right routine and the consistency to really repair that damage and bring your skin into a healthier, younger, functional state.

51:21And so I usually say it's never too late to start. Obviously, the earlier that you start, the better. We know that we do start accumulating those zombie cells as early as our in our 20s so oh no yeah because i mean in the end like our life is like is the build up of this you know small habits and and so if we are aware if we're lucky to be aware in our 20s that amazing right like let's use sunscreen. Let's use like a good, you know, moisturizer with a peptide that has, you know, scientific validation behind and just maintain that skin like, you know, younger, healthier, functional longer. It's easier than reverse.

52:11So, yeah. Yeah. It shouldn't be a surprise because even osteoporosis, right? We're always like, oh, that's the problem when you're in your 60s. It's a problem in your 20s and it keeps going and then it manifests in your 60s, 70s plus. So I am curious though, like what would you say is a good routine? Obviously, you're not a doctor. This is not a prescription, but just you have been deep in the research. So in terms of someone has had sun damage, let's say they're 50 plus years old, what would be a good daily skincare routine for them? Yeah, I mean, I'll share mine, and probably I can extrapolate for someone that has more sun damage than I do.

52:55But I would say start with like, you know, a night cleansing your skin with a gentle cleanser. You can double cleanse or you just like have a gentle cleanser that doesn't disrupt your skin microbiome, shouldn't dry out your skin. I think at their 50s, primarily, we are trying to preserve like our skin and, you know, the barrier, which is really, really important for everything else. So a gentle cleanser and something that's not a strip out all of your oils, really, really important. Then you are going to come, I would say, start with a moisturizer that has peptides that have been scientifically validated or clinically validated.

53:41And then I would come with the retinol. You could add another step of antioxidants more specifically that could help with brightening. so we know that you know the seafaring lake like it's like one of very powerful blend of antioxidants i'm more fan of antioxidants than the prescriptions ones but obviously everyone is in a different phase and you know you you can go through the prescription route as well one other thing that we have that we recommend it's an eye cream because what do we when we're studying, we found that the skin around our eyes is 20 to 30 years older than the skin around, you know, our face, like samples and cheeks.

54:31And we know that the skin is five times thinner, accumulates more of the zombie cells. And obviously it's really hard for you to, at least for me, like I don't put like a retinol on my eyelids. I feel that it's too much already. So we formulated an eye cream that has a higher concentration of the peptide and the clinical studies, the data is the strongest one in terms of increasing collagen, reducing fine lines and wrinkles. Even the eyelid that starts to droop a little bit, like we could see a bit of a lifting effect and elasticity. elasticity. So this is the most like powerful product that we have in terms of efficacy.

55:18And that's primarily it. And then you could like apply the retinol on top of the moisturizer, as I said. And in the morning, very simple, at least I try to keep a very simple routine. I don't cleanse my skin in the morning again, because it's already, you know, clean from the night before. I just rinse it with water. If you have like very oily skin, which is usually not the case for 50-year-old women. Just rinse your face and then apply your moisturizer. In our case, our SPF already has all the antioxidants, so I skip like I don't need to have another vitamin C. And that's it. Like, I'm ready for the day.

56:01Yeah. Well, I do have to say that I have used your eye cream. I've been using that. I didn't have any reaction to it, despite having sensitive skin. And it's back to school week. And I was joking with my husband that I was like, I swear this eye cream is saving me from how tired I really am from actually anyone knowing. Like, nobody knows that I'm actually tired because something I notice as I enter my 40s is that if I don't get great sleep, it's like really around my eyes that I will notice it. And sleep definitely wasn't great. Like these last few days is just like, you know, I don't know if you have kids, but you get like 1000 emails and there's 1000 things to do before school.

56:45And I've been so anxious about like, don't mess this up for him. And so I really appreciate your eye cream. It's interesting that you said this is the highest efficacy product. Can you say more about that? Yeah. So for every product that we have, we run our internal data and we also run clinical studies that is done by a third party. So in our internal data, when we compare the levels of collagen that we induce with our eye cream compared to the face, it's more than double in terms of collagen production. And the genes associated with aging are also more reduced. and for the clinical studies we saw a really strong improving hydration so it was like 32 percent measured by instruments there's where why i don't look so tired this week right there that 32 percent bump in hydration yeah and the hydration will really help with like smoothing out the fine lines and and we also saw a 24 percent increase in elasticity and i love that all this data, it's measured by instruments.

57:53So it's like, you know, it's quantified. It's not like consumer perception that like, I feel, you know, this way or that way. For me as a scientist, I always look for the hard data. And again, with a formula that it's validated to be safe for sensitive skin. So it's really good for that delicate skin around our eyes. mm-hmm so i want to shift the conversation because i asked you the skincare routine of like what if you're in your 50s but i bet there's a 20 something right now being like hold up she said these senescent cells are starting in my 20s and you're just going to glaze right over this no we're not we're going to come back to this so i want to jump back so let's say someone's in their 20s should they have the same skincare routine as someone in the 50s i think you can reduce the amount of steps So I think for the 20s, like if you don't have like discoloration, I don't think you need like a vitamin C.

58:52You can stick to sunscreen, a moisturizer, like our face moisturizer already has like the peptide that will fight the senescent cells that will provide some antioxidants. And I think that's it. I think if you want, yeah, if you want to start with a very light retinol, but again, I would do like a few times a week. I'll definitely not be aggressive for your skin if it doesn't need to. You want to maintain your skin. You want to make sure that your skin is thriving and you don't want too much on your skin. That's like my advice for younger people. Yeah. Now, the other phase of life that women go through is pregnancy.

59:37And we said like, you know, the pregnancy glow earlier, but it's not like that for everyone. For some people, they get really red and splotchy. Melasma is a thing that, you know, I think a lot of women dread, whether they're going to get it or if they have it, trying to get rid of it. Can you talk to us about how pregnancy hormones are impacting the skin? Yeah. And I maybe I was saying that this is not, you know, one of my main expertise and mainly because it's really hormonal driven. So hormonal influences is really hard for us to understand in the lab, but there's something more systemic. And so I would probably recommend, you know, talking to a dermatologist because I know that some of the brightening, the vitamin C could help.

1:00:25But I know that some melasma cases you definitely need to consult with a dermatologist. Mm-hmm. Well, I think that's important for women to hear because sometimes we think like we have to DIY everything ourselves. And sometimes you just need to go to a provider. And I appreciate that you're like, it's really hard in the lab. Yep. That's why we don't have a lot of studies on a lot of these things because hormones are hard just because you're pregnant and your neighbor's pregnant and your best friend's pregnant doesn't mean you have the exact same hormone profile or that your genetics responds to those hormones in the exact same way.

1:01:04So it can be really complicated. But I do appreciate that at the top of this interview, you talked to us about how these peptides can be used in pregnancy because we're seeing more women are having babies in their 40s. And they're like, wait, what do I do now? Because I can't do the retinol and I can't do the Botox and I can't do the lasers and I can't do, you know, all of the things that people talk about out there, which is, you know, there's a wide variety of things. And so knowing that you can still access these peptides and that it's modulating inflammation, I think is also really interesting as well, especially as I consider that as you shift into postpartum, we can see a huge inflammatory response just by way of the immune system shifting with the loss of the placenta and the birth of baby.

1:01:57Yeah, no, 100%. And counteracting that inflammation with like those soothing, that's a time that I think you needed to be, you know, give some extra love to yourself. And, you know, don't try too much. Like you recover and I haven't had kids yet. So I'm still to go through that phase hopefully soon. But I think we just needed to sometimes be patient as well. And with time, our body has this beautiful ability to recover. And so be gentle to yourself, be patient. And there are alternatives that are safe, that are gentle for your skin, so you can rely on them as well. You mentioned earlier there's lifestyle choices that can accelerate skin aging.

1:02:42I would love to go through a list of those so people know what are the things that we should consider avoiding. Yes, definitely. So, I mean, the first one, basic one, we'll start with the, again, the sun exposure that we already talked. And I think something that we needed to be mindful that in our daily basis, we are being exposed. You know, you can be by a window, you can be commuting. And so a lot of people are still like, I'm just applying if I'm going to stay in the sun like for hours. I think that should be a daily habit. if it's a product that's safe for you. I know that there is some concerns around sunscreen out there, the chemicals, and they could potentially, you know, have some implications, but there are the safe, you know, mineral alternatives like the zinc oxide that you shouldn't have any side effects and it can still feel really nice into your skin.

1:03:43You need sleep. It's another one. We know that impacts everything and obviously impacts our skin so much. I'm just laughing because I outed myself with the sleep.

1:03:59If you can, you know, give yourself like that eight hours, like more than eight hours is like how much you're recovering, right? So how much you're actually resting, because that's the time that your body, your skin is really repairing all the damage that you were accumulating the whole day. So if you don't give your skin the right time, like your skin will wake up tired and will, you know, go through another battle. And so I'd say sleep is a really key one. A clean, you know, healthy diet full of antioxidants. You want to avoid sugar that is going to increase your inflammation. you want to increase your levels of proteins you can supplement with collagen that you are going to give your skin like the building blocks that your skin needs to build your own collagen doesn't mean that the collagen that you're drinking is going to go straight to your skin but you are allowing your body to have like the the building blocks that it needs and on top of that the collagen, it can be also antioxidant, so it can help in other ways and it can help with your joints and other things as well.

1:05:19We know that exercise and all of that also, you know, the movement impacts your skin. And finally, you know, stress. I think stress is another one that to me, you know, running a company, it's one that I'm trying to fight and manage the most. and we know that the increase in cortisol is going to impact inflammation. We also saw even cause things like hair thinning, hair loss that we didn't talk about. But again, senescent cells are also involved in hair thinning and hair loss, and stress is a major driver of hair thinning. And so trying to manage that stress, you know, with meditation or whatever you do to kind of disconnect and reset, I think it's one that most people may ignore based on our busy daily lives and can really impact in your skin in so many ways too.

1:06:27We're going to come back to the hair loss because there's nobody listening who's going to let me pass that one up. But you said sugar leading to inflammation as a driver of skin aging. Can you explain more about that?

1:06:56save with the personal price plan. Prices are based on rating plans that vary by state. Coverage options are selected by the customer. Availability, amount of discounts and savings, and eligibility vary by state. Yes. So basically what happens when we're eating a diet full of sugar is that sugar is going to bind to proteins and it's going to form what we call advanced and glycation products, AGE. And this is basically making your collagen more stiff and not like malleable. So you're going to lose like the firmness. Your skin is not going to be as bouncy the more AGEs that you have in your skin.

1:07:40So a diet full of sugar will lead to more AGEs will lead to inflammation, will cause your collagen to be stiff and not like malleable as you want it. We call it cross-linking the collagen. So it's not like working properly. And that is also signaling inflammation to the body. So definitely not only that, but you know, when you eat like either like a piece of meat or bread, that's a little burned, is also full of, you know, advanced glycation products. And you should avoid that, the burn piece as well. I'm always like, with people around me, don't eat that burn part. And some, some people love that.

1:08:23I have a father-in-law who eat like burnt toast and I'm like, no, don't do it. But I also have a 12 year old who like, he's like a little food patrol at times where he's like, is that raw? Is that overcooked? Like, and so he'll get on his grandpa about it. Like, you can't eat that. It's not good for you. So, you know, as you're bringing this up and I'm thinking about like, okay, so we've got perimenopause, menopause, we're having loss of collagen. We've got these, you know, glycation elements in our skin that are also contributing to the problems that we face in terms of what we're trying to avoid aging.

1:09:03But the other thing that was coming up is like this excess sugar is aging your skin. It's inflammatory because of this process. But that excess sugar is also what we see connected to the increase in visceral adiposity for women, which is the fat that packs around their organs, which also increases inflammation. So just for our listeners to make that connection of like, this is, you know, not just about metabolic health. And we're talking about excess sugar. We're not talking about you ate berries. We're talking about, you know, you're eating cake, ice cream, soda, like adding tons of sugar to your coffee.

1:09:40You're going past 25 grams of additional sugar that's coming outside of your natural food sources. That can be so problematic for our cardiometabolic health, but also our skin health as well. And I think that's a really important connection for people to make. Now we're going to go into that hair loss because I know that that peaked listeners' attention. So you said stress can be a driver of hair loss. What else should women be considering if they're experiencing hair loss? Yeah. So one of the things that we realized as we were studying zombie cells in the skin and eventually we all, you know, I don't know how many people realize that, but like your scalp is basically your skin as well.

1:10:23It's a continuation of your skin. And so our hair follicles are embedded in that scalp, that's the skin. and that also is aging and it's accumulating those zombie cells. And what we found is that there are studies showing that the accumulation of zombie cells in hair follicles is the major driver of like age-related hair thinning, which basically comes around our 50s. It's different from the male or female pattern hair loss that's more like hormonal driven, like androgenic related, but also stress can cause more accumulation of senescent cells in the hair follicles, and that can lead to hair thinning and hair loss.

1:11:14We even validated this in the lab that we expose the hair follicle cells with hormonal stress, and then it caused senescent cells and then we treated the peptide and we could reverse that like senescent cell. Again, we were looking for a solution that would prevent or reverse hair thinning and hair loss without including like drugs that can, you know, have some side effects. You know, there are like many drugs out there that can block, you know, the conversion of testosterone to DHT, which we know DHT is basically this form of testosterone that can bind in the hair follicles and induce hair shrinking.

1:12:02But all of these drugs can have so many side effects. You don't want to take it if you're pregnant. You definitely don't want to take, you know, postpartum. So, and postpartum is one, you know, period of your life that you're likely going to experience hair loss because you have like a peak in estrogen and then there is a decline and then you're going to experience some shedding. And so we basically develop a hair serum that contains the same peptide that fights these zombie cells in the skin, but now fighting the zombie cells in our hair foliase. So it's pretty safe. It has beautiful results in terms of increasing hair density and hair thickness.

1:12:45It also improves your skin microbiome because our microbiome also changes with aging and improves your scalp health. And I think it's another area that we usually treat our skin to prevent fine lines and wrinkles, but we don't treat our scalp to prevent thinning and hair loss. That is likely going to happen at some point of your life. You know, at least like 70 to 80 % of, you know, people, men and women experience some hair thinning and hair loss throughout their lives. And I think having this proactive, more like preventative approach is one that we should start incorporating, but also can be used if you're already experiencing, you know, some time of shedding or hair thinning.

1:13:35We have seen, you know, great regrowth in terms of recovering that healthy, you know, hair growth cycle. And this is the same OS1 peptide that you were talking about earlier? I'm curious. So you've seen regrowth. Has it been quantified? Like how much hair is able to come back? And how quickly does it come back? So this usually takes longer hair. Hair loss is so lame like that. It takes so long to bring it back. It takes usually from three to six months. After six months from our clinical study, we saw 40 % increase in hair density and 40 % increase in hair thickness. So that's really significant and impressive because, yeah, the hair folio that was becoming thinner is now like 40 % thicker.

1:14:33So it is stronger. It's going to stay in that hair growth cycle for longer. And so we have from our studies, like really, I mean, strong quantitative results. We have really strong, you know, before and afters that obviously everyone wants to see. But I think really interesting to see that combating these zombie cells in our hair follicles is also a way to combat like hair loss and hair thinning. We typically, so in medicine, what the belief is currently is that once miniaturization occurs at the hair follicle, so the shaft is becoming thinner and thinner, that's irreversible. Are you saying that you guys actually have seen the hair become thicker again?

1:15:24Yes. It's hard to quantify exactly the same hair follicle. Right. Totally. But I would say that if you're starting the miniaturization phase, it's not completely like, you know, to the end yet, you can reverse that. So it always depends on the phase that you are. But what you don't want is that hair follicle to completely die. And so that you cannot recover. But if it's in the beginning of the miniaturization phase, you can still recover that hair follicle. That's so interesting. And is this, this is a serum, do you have to apply it a couple of times a day? Is it once a day? Yeah, usually we recommend it twice a day or at least once a day.

1:16:12It's a water-based serum, so it shouldn't, you know, make your scalp or your hair greasy. You can still style, you know, blow dry, whatever you like to do. But ideally, twice a day, morning and night, You can apply on a wet hair or a dry hair. But yeah, the consistency here is the most important thing. And consistency day and night, if possible, it makes it easy if you're like wet hair, dry hair, because I could just see that it being an easy part of the routine. And then give it at least six months to be able to really see the outcomes there. Yeah, which is pretty typical. I mean, anyone who has had a baby, as you were saying, in postpartum knows that at four to six months postpartum, your hair is going to fall out.

1:17:04And then it's going to be by the time hopefully your baby starts sleeping around 12 months, you start seeing your hair come back. And still, they don't always sleep. But I would imagine, you know, using this serum, it's helpful. But if you're still doing things like skipping sleep, smoking, not practicing stress reduction, that might be able to negate some of the effects? Yeah, 100%. Yeah, that will definitely impact. So in the end, we are always talking about like a holistic approach, right? And so we know that the stress, the lack of sleep will impact. But you can minimize. So, you know, there is obviously sometimes you can't tackle everything at the same time.

1:17:50But, you know, if you can add that layer of support to your scalp will help. You know, it could be better. Yes. If your internal body is helping. Yes. But I think I wouldn't not do it because you can't do everything at the same time. And I know that for certain hairstyles, like people don't wash their hair every day. Does that have an impact? Do you need to be washing your hair every day and applying the serum? Or is it something that, you know, if you have a particular hair type that you're like, I need to wash it every other day or I get it styled a certain way, I can't wash it for several days.

1:18:26Would that, you know, negate the effects or does the product build up? The product itself shouldn't build up. It's very light and should absorb really easily. I think if there is a buildup of, you know, oils and other, you know, dirt, maybe of like the day-to-day that can impact the absorption of the product so obviously a clean scalp will absorb better uh but i yeah i think you know i wash my hair every other day and i still wear it every day and and i think that's totally fine and are you using it preventively i use that's a very personal question i apologize that's too personal like the you know male female uh pattern hair loss in running my family so i know you know how impactful you know in our mental health and you know in many ways hair can be to you absolutely yeah when you start like seeing your parts like showing, it definitely has an impact.

1:19:30So I use both, you know, I actually want to reverse. And so I do other things. I do the hair light therapy. Sometimes I do the PRPs. And so I'm trying everything because I'm on that phase of, you know, trying to preserve and, you know, regrow as much as possible because I already feel like the thinning and that's not fun. No, no, for sure. I have hypothyroidism. I remember when, before I was diagnosed, losing my hair and just like clumps of it coming out. And it is, until you've gone through it, you don't understand how distressing it is on a mental health level. For people who know they have, you know, family, familial hair loss, or, you know, they're they're just like, I want to keep my hair for as long as possible, as luscious as possible.

1:20:27When should they consider using this as a preventative measure, this peptide? Yeah. I think if they have this androgenic-related baldness in their family, I would start as early as their 20s. If they don't have and they would just want to prevent, I would probably start in my 30s. I wish I had this product when I was in my 30s because I think it would be easier to maintain my hair. But if you have in your genetics, I would start probably in your 20s. And I know that some people can start even, you know, getting bald around your 20s. So that's one thing that the earlier the better if you have in your family.

1:21:14Yeah, I think that's a good thing for listeners to consider. I'm also curious, are there things that people are doing unknowingly that's maybe damaging their hair or, you know, can be having a negative impact? I mean, other than like the stress, the sleep, some of the things that we've talked about. Yeah, definitely. You need to be careful with like the chemicals, the bleaching of your hair, how, you know, how are you dyeing your hair, those chemicals that go into your scalp. they can definitely impact your scalp microbiome, your hair follicles. So I would be aware of that. I would be aware also of sun exposure on your scalp because obviously if your scalp is getting damaged and sunburned, that's also going to impact the aging of your scalp and consequently your hair follicles.

1:22:16And as always, like the products that you wash your hair, you clean your hair, you need, ideally they would be, you know, they would contain like safe ingredients because otherwise you're causing more irritation in your scalp, more redness, and that's all contributing to that, you know, aging process, as we know. You've brought up the skin microbiome, the scalp microbiome. What do you think people should know about that? I think people should know that our skin, our scalp, our gut. We have these microbes and, you know, bacteria, fungi that are important to maintain the health of our bodies. And, you know, they produce certain metabolites.

1:22:59They protect, you know, our skin. They help even like, obviously in our gut, like metabolizing, you know, our food and absorbing the nutrients. So maintaining that microbiome like healthy in a homeostasis state's really really important and when that microbiome is disrupted the gut like we have leaky gut you know in our skin you can have a lot of things related to you know either eczema or psoriasis or you can have acne that's also dysregulation It could be hormonal as well, but it could manifest if your microbiome is dysregulated. And your scalp, you can have like an itchy scalp, a flaky scalp, and dandruff.

1:23:50And all of those things can be associated with like an unhealthy and unbalanced microbiome. So protecting that microbiome basically means like not using things that are stripping away all of your good, you know, bacteria. So it can be, you can't have like, you can't use like soaps or detergents that are really stripping that good bacteria and use products. There are products, obviously, you know, probiotics for the gut, but they are like in our scalp serum, we have like a prebiotic for the scalp as well that helps like nurture that microbiome. So it will continue to, you know, perform at its best.

1:24:33That's so interesting. Of course, I'm familiar with prebiotics. And for my audience, I will link to the gut health episode where I talked all about prebiotics internally, how they feed those critters that grow in your gut. And it's one of the best things that you can do for microbial diversity. I mean, everybody's always looking at like, how do we eradicate things? And why do I have this dysbiosis? And we need to be consuming prebiotics. But the concept of actually putting prebiotics on your scalp is totally new to me. Can you say more about that? Yeah. So basically, our scalp microbiome can change with aging.

1:25:08and there are ways that you can help like shift that microbiome to a healthier one. So you can support the growth of the good bacteria that will support the growth of your hair follicles and you can decrease the growth of the bad bacteria that is associated with hair loss. So there are ways that you can do this with prebiotics, so nurturing the right bacterias and when you have the right bacterias, usually they prevent the growth of the bad bacteria and the same with fungi. A lot of ingredients can help like modulating that microbiome in a way that you have the right ones there that are supportive to your scalp health.

1:25:58And that's one thing that impacts not only, again, your scalp, but obviously your hair growth. Yeah, that I think probably is a big light bulb moment for a lot of people who struggle with, you know, fungus on their scalp. It's something that's really common. Nobody wants to talk about it because it's really shameful. And I think this is going to be one of those big breakthrough moments for people as well, hearing that like there are actual ways to cultivate the microbiome of your scalp because we also know in the gut, when we have fungal overgrowth in the vagina, when we have fungal overgrowth, we have to cultivate the good bacteria if we want to prevent that from reoccurring.

1:26:42So that is absolutely fascinating. We'll link to all of the products that we've discussed today, including that scalp serum, because I know people are definitely going to be, I can already see them in the comments, like give me the link to that. But I wanted to finish up by asking you if you could correct one major misconception women have about skin aging, what would that be? First of all, skin aging and like having your best skin will mean different things for, you know, every person. I think we all should look for that skin that make us feel confident, that make us feel good. and a healthy skin usually is halfway there.

1:27:25Like a healthy skin is a good looking skin, is a skin that is telling you that your body is healthy. And obviously you can go further if you want to do the injectables and the Botox. But I think to me, as I age, I try to optimize my skin in a way that I'll feel and look my best. But I'm not after, you know, that the flawless and some people are after that the glass skin that's like a completely perfect skin. I'm looking for my best skin that I still feel, you know, myself. but not in a way that I could, you know, be doing too much to my skin in a way that I'm, you know, kind of disrupting, you know, what my skin is supposed to be and to mean for my body.

1:28:24So in the end, I think about aging skin is something that we are optimizing and we shouldn't necessarily fight for like that 20 year old skin again. But like embrace that, you know, even some lines, you know, if they're an expression of the memories and the laughs that you had throughout your life, that's my philosophy. I still would do, you know, a lot of things to look, you know, at my best, but I think I try to respect that balance. And so that's my philosophy. I think in the end, like less is more. And there is still ways that you can achieve that great look and, you know, prioritizing health.

1:29:08I think health, you know, should always come first. That's such a refreshing message, I think, for women to hear, especially in the age of the Kardashians. No shade to them. I am all about whatever makes you happy and how you want to live your life. I support you in making your decisions. And yet I think sometimes when we see radical facelifts and all of these procedures, women feel like there's a new bar, a new hurdle that they have to be leaping over. And so to hear a message from a scientist who has a skincare line saying that, you know, embracing the natural process, but nourishing your skin so that it can have the best integrity, the best of health is just a beautiful, beautiful way to end this conversation.

1:29:54So I appreciate you sharing your expertise for all of these aha moments that I think our listeners are going to really appreciate and for the work that you're doing to transform skincare for women for the better. Well, thank you, Jalene. Yeah, this was a wonderful conversation. Thanks for allowing me to share a little bit with your community and thanks for all that you do. I think you are, you know, obviously a beacon of like so much great information and inspiration for a lot out there. Oh, well, thank you. That refresh you've been putting off until the right deal came along? It's here. Wayfair's Black Friday in July sale is happening now so you can finally get the style you've been waiting for for less.

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