In short
Explains insulin resistance as a “key-and-door” problem where insulin receptors stop working, leading to high blood sugar, inflammation, hormone disruption, and links to prediabetes/type 2 diabetes, heart disease, fatty liver, Alzheimer’s, PCOS, infertility, and low testosterone. Claims it’s largely driven by ultra-processed foods and refined carbs/sugar, and is reversible in ~30 days via diet, exercise, sleep/stress control, and specific supplements.
Guest backgrounds
No guests mentioned; solo host Dr. Josh Yack.
Key claims
~38% of US adults have prediabetes/insulin resistance; 80% are unaware. Ultra-processed foods are the main cause. Weight loss (10%) improves insulin resistance. Diet beats metformin for prevention (citing Diabetes Prevention Program). Stress/cortisol and sleep deprivation worsen insulin sensitivity.
Notable examples
Two Nashville professors (one ~60 lb overweight; one ~30 lb) reversed type 2 diabetes off meds (40 days for her, 60 days for him). A patient reversed diabetes in 30 days using Ceylon cinnamon/pumpkin pie spice plus a high-protein smoothie.
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VOIntroduction to Insulin Resistance
0:25 to 1:51
Learning about insulin resistance and its consequences.
“Legally, we can't say drinking Storm makes you smarter and more focused.”
Understanding Insulin's Role
2:08 to 4:04
Exploring how insulin works and its importance to body health.
“And first off, I want to let you know what insulin is.”
The Prevalence of Insulin Resistance
4:12 to 6:06
Discussing alarming statistics about insulin resistance in America.
“Nearly 100 million American adults, more than one in three, the exact numbers, 38 % have prediabetes and over 80 % are unaware they have it.”
Causes and Consequences of Insulin Resistance
6:11 to 7:20
Identifying causes of insulin resistance and its serious health implications.
“diets like Japan and certain blue zones, areas like parts of Greece and Italy, they have significantly lower rates of insulin resistance, often under 8%.”
Metabolic Contributors to Insulin Resistance
7:24 to 9:21
Discussing various contributors to insulin resistance and their effects.
“And I want to walk you through the biggest metabolic contributors to insulin resistance.”
Strategies to Reverse Insulin Resistance
9:50 to 14:00
Exploring dietary and lifestyle strategies to combat insulin resistance.
“Now, as I mentioned earlier, one of the greatest contributing factors to insulin resistance is poor diet.”
Diet Strategies for Insulin Resistance
14:00 to 16:47
Learn dietary recommendations to reverse insulin resistance effectively.
“Here's one other thing I want to share with you.”
The Impact of Weight Loss on Insulin Sensitivity
16:47 to 19:13
Understand how weight loss can significantly improve insulin sensitivity.
“Complete reversal if you do the right things.”
The Dangers of Metformin
19:13 to 21:07
Explore the side effects of metformin and alternative approaches to diabetes management.
“If you come into their clinic, they prescribe metformin, and that's all they do.”
Fasting and Meal Timing Insights
21:15 to 23:28
Learn about the benefits of meal timing and fasting methods for better health.
“And I do think being aware of how much we eat and not overeating is important.”
Show all 14 chapters
Exercise, Sleep, and Stress Management
23:28 to 28:03
Understand the role of exercise, sleep, and stress in reversing insulin resistance.
“Well, they were inspired with Chinese medicine, Kampo.”
The Importance of Lifestyle in Insulin Resistance
28:03 to 30:05
Learn about the impact of exercise, sleep, and mindset on insulin resistance.
“And there was one large scale study published in JAMA in 2011.”
Supplements and Herbs for Insulin Resistance
30:10 to 36:39
Explore various supplements and herbs that can help improve insulin sensitivity.
“Now let me walk you through the supplements and herbs that most improve insulin resistance and help heal and reverse diabetes, including prediabetes.”
Practical Steps to Reverse Type 2 Diabetes
36:39 to 39:16
Learn effective dietary and lifestyle changes to reverse type 2 diabetes.
“Protein and fiber, protein and fiber, protein and fiber.”
Transcript
Automatic transcript. May contain errors.0:00This episode is brought to you by Google Health. Stop chasing someone else's definition of health. What matters is what's healthy for you. Google Health offers a new kind of coach built with Gemini for effortless tracking, sleep insights and holistic coaching tailored to you. Visit GoogleStore.com to learn more and start a new relationship with your health. Requires Google account, Google Health app, Internet and Google Health premium subscription. Features subject to change. Availability and results vary. Not intended for medical purposes. Works independently of Gemini apps. Check responses for accuracy.
0:30Legally, we can't say drinking Storm makes you smarter and more focused. But with zero sugar, 200 milligrams of caffeine, and immunity support, you're smarter and more focused for drinking Storm. Storm. Good energy in, good energy out. Energy for life. Mornings have a rhythm. You can hear it, feel it. And at Quaker, we fuel it. With 100 % whole grain oats and a good source of fiber in every bowl, helping you turn that rhythm into your soundtrack for a great day. Fueled to start whatever's next. Quaker, official sponsor of FIFA World Cup 26. I-O, let's go! I-O, let's go! Hey, what if the root cause of your stubborn weight gain, brain fog, type 2 diabetes, and your low energy isn't your genetics, but what if it's something that you can actually reverse and in most cases reversed without medications.
1:29Now today I'll be talking about insulin resistance, why it's skyrocketing in the United States, in the Western world, in the exact diet, lifestyle, supplements and herbs that have been proven with science to help you reverse insulin resistance, help balance your blood sugar and heal your body at the cellular level. Welcome to the Dr. Josh Yack Show.
2:07Now, this is an incredibly important episode because so many people are struggling with insulin resistance. And first off, I want to let you know what insulin is. Insulin is a hormone. It's actually a peptide, tripeptide hormone, that is critical for bringing sugar into your cell. And once that sugar is into your cell, your body can use it, your mitochondria can use it, your mitochondria and your cells can use that to create cellular energy. That energy then runs your organs, your cells gives you the energy you need to be healthy, to function properly, for your thyroid to produce the right amount of hormones, for your stomach to digest food, your body has to have cellular energy.
2:52and insulin is a critical hormone in that. Now, here's what happens. If you have insulin resistance, okay, and this is basically what happens is, this is where like if you would stand next to a really loud speaker and over time your hearing would go deaf, somebody would start talking to you and say, what'd you say? I can't hear you. If that happens over and over and over again, which is what happens to your cells, you have these things called insulin receptors. So they receive the hormone insulin. those can stop working. They basically break, okay, stop working. And then insulin can't go to the receptor site.
3:28So then now sugar can't be let inside your cell. It's like insulin is like the key, right? Insulin is a key to the door, unlocks the door, opens the door. Now sugar can get inside your cell. Well, if sugar can't get inside of your cell, it causes inflammation in your bloodstream. That inflammation then will set off an immune response, which will then lead to chronic pain can lead to autoimmune disease, inflammatory bowel disease, and then hormone disruption throughout your body because insulin also acts as a key to other things in your body, allowing other hormones to do their job like cortisol, estrogen, testosterone, and thyroid hormones.
4:07So it is critically important that you have proper levels of insulin. But here's the reality. Nearly 100 million American adults, more than one in three, the exact numbers, 38 % have prediabetes and over 80 % are unaware they have it. A global analysis estimates that 27 % of adults worldwide have insulin resistance or just under one in three. But again, in America, it's nearly 40%. I want you to sit back and really think about that. Okay. Just sit back thing about this. 40 % of American adults have prediabetes and insulin resistance. Okay. And this is going to increase your risk of every single health disease you can think of.
4:51And here's the other scary reality is that these numbers are also growing in children. In fact, we're going to have that number that's 40 % now, or 38 % exactly, will be at 50 % in the near future. So half of Americans, 50%, will have pre-diabetes and insulin resistance if we continue with the current trend here in the next 20 years. The International Diabetes Federation says rising rates of insulin resistance and diabetes is alarming, and really, it's an emergency. I know that we tend to worry about COVID-19, these sort of viruses or infections that are a threat to us. Pre-diabetes and insulin resistance, which is really tied to obesity and a number of other health issues, that is a much bigger risk.
5:41It kills way more people, way more people than something like COVID did or other types of viral threats. And the main cause of prediabetes in the United States and insulin resistance is the widespread consumption of ultra processed foods, which are highly palatable. They taste great. They're very calorie dense, but they are void of nutrition. Now let's compare the United States to other countries. Countries with a whole food traditional diets like Japan and certain blue zones, areas like parts of Greece and Italy, they have significantly lower rates of insulin resistance, often under 8%. We're at 38%.
6:23They're at 8%. This means that these countries have about one-fourth the rates that we do in the United States. And as I mentioned earlier, insulin resistance is a hormonal issue where your pancreas overproduces insulin in an attempt to lower your blood sugar. But, again, over time, they get burned out, they get broken, the receptor sites. Now, the good news, by the way, is you can repair these receptor sites. But what happens is they get broken, and so now the sugar stays in your bloodstream, And so your body produces more and more insulin to try and fix the problem. And then when you produce all this insulin, it's a hormone.
7:00So when one hormone gets off, all of your hormones get off in your body. And chronic insulin resistance has been linked to, of course, type 2 diabetes, but also heart disease, fatty liver disease, Alzheimer's, PCOS, infertility, and so much more. Low testosterone in men. So major, major health issues. And I want to walk you through the biggest metabolic contributors to insulin resistance. Here's what they are. Number one, of course, is obesity, especially from excess visceral fat. So many people don't know this. Your body fat is an organ, just like your muscles and organ, just like your heart is an organ and your liver is an organ.
7:43Your body fat acts as an organ. And when you have too much body fat, it actually causes your body to have more insulin resistance. It imbalances hormones. Your body will actually release or not release certain levels of leptin and ghrelin and other hormones, which will then cause insulin to be off. Another major contributing factor to insulin resistance is, of course, a poor diet that's high in added sugar, refined carbohydrates, and also ultra-processed foods. But other things also contribute. Lack of nutrient density in your diet, like our depleted soil today. A sedentary lifestyle where you're just not moving much, you're just sitting all day long.
8:25High levels of stress, poor sleep. And yes, there is a mild genetic component that can also contribute. There was a Journal of American Medical Association study. This was done on 45 ,000 participants. And they found that even mild elevations in your fasting blood sugar, especially combined with high body mass index, so if you're overweight, substantially increased the progression of diabetes, which is the eighth leading cause of death in the United States. The CDC now estimates that one in every three adults has prediabetes. The signs are there long before a diagnosis, things like constant fatigue, stubborn belly fat, sugar cravings, brain fog, frequent urination, and increased thirst.
9:13And these are all symptoms of insulin resistance, the root cause behind most cases of type 2 diabetes. Now, here's the good news. This condition is completely reversible with the right diet, lifestyle, and healing herbs. And if you or someone you love is struggling with blood sugar issues, head over to DrAxeDiabetesClass.com to watch a free training on how to naturally balance your blood sugar and reverse your symptoms. That's DrAxeDiabetesClass.com to take back control of your health today. Now, as I mentioned earlier, one of the greatest contributing factors to insulin resistance is poor diet.
9:58And again, I just want to be so clear about this. You may think to yourself, well, I don't think I have insulin resistance. 80 % of people that have insulin resistance don't know they have it. Okay. If your energy is fluctuating up and down all the time, if you have PCS, if you're overweight, if you have blood sugar issues, then you have insulin resistance. Okay. 80 % of people that have it don't know they have it. Okay. That's the problem. That's the reality. and the biggest way to fix it, the most effective way to fix it is via your diet. Now, I wanna walk you through some studies and strategies that can help.
10:32Now, the first strategy here is for men, not as much for women due to the difference is in hormonal nature of men versus women. Doing time-restricted eating like intermittent fasting has been shown to balance insulin in men, okay? And so I think that is a good strategy for men. For women, I think you can get your eating window down to about nine hours where you're maybe eating at like 8 a.m. and noon and then again at 5 p.m., okay, within a 10-hour window or so, maybe even nine. I still want you doing three meals a day, though. That's fine. But only eating within a four - to six-hour window for women, it typically imbalances the hormone of most women.
11:14So it's not something you want to do in most cases. Not to say there's not some women in a group that are very, very healthy where their body can handle it, but the most it's going to be too big of a stressor on your hormonal system. The biggest thing, of course, that you want to resist to reverse insulin resistance is ultra-processed food. So it's fast food. It's the sodas. It's the stuff that all of you know you should be staying away from, and you want to eat more real whole foods. The biggest culprit, though, by far is going to be sugar and refined grains. that cause insulin resistance. So if you're doing, again, soft drinks, if you're doing anything with added sugar, added sugar and then refined carbs, white bread, white pasta, potato chips, those sort of things, they're going to contribute and cause the biggest problem.
12:04So again, stay away from processed sugar. And you want to make sure, and listen, highly processed fats and seed oils are not good for you either. And you want to stay away from those. that's probably secondary, but the biggest is refined carbs. You want to increase your content of protein, fiber, and healthy fat. That's the key. All right. That's the key right there. The most effective diets for reversing insulin resistance are whole food-based diets, Mediterranean diets, and diets that are more ancient nature, like a Biblio diet. These are diets that consist of eating real food and real food alone.
12:43When you look at a Mediterranean diet, It's high in wild caught fish. It's high in extra virgin olive oil. It's high in a lot of tropical fruits like citrus, right? It's eating that sort of diet. You look at a Biblio diet, what they ate in the Bible. It's a lot of pomegranates, it's figs, it's avocado, it's lots of olive oil there as well. It's lots of grass fed red meat, raw organic dairy, those sort of foods. But the key is this, high protein, high fiber, moderate fat, low moderate carb. Not low carb, not keto. You don't need to do that. You want to eat carbohydrates that are high fiber, high nutrient.
13:26So if you're choosing fruits or you're choosing carbohydrates, skip the white flour products, skip the, you know, refined pasta, you know, do pomegranate, do an apple, do berries, very high fiber, low glycemic fruits. Those are better options. Even sweet potato and butternut squash. Those are better carbohydrates for you to choose. Even quinoa and whole grain brown rice. Those are better options for you to choose from. And, but again, And those are more on the low to moderate amount. And you want to do high protein and high fiber. Here's one other thing I want to share with you. It's not good typically to do high carb at any meal, but high carb and high fat together will cause you to gain the most weight.
14:12Okay. So typically in the morning, what I recommend for my patients is do high protein, moderate carbohydrate for lunch, do high. And of course, high fiber for lunch, high protein, high fiber. and then you could do either carb or fat. And for dinner, high protein, high fat, no carbs, very low carbs, okay? That's sort of the ideal way to eat is lots of protein, lots of fiber, lots of nutrients in your food. And if you can do that with lots of organic meat, lots of vegetables, some fruits and healthy fats, you will heal, you will balance your insulin and you'll do it fast. Now, there are other things you can add in your diet, which I'll get into in a little bit as well.
14:55some specific herbs and supplements that will take your blood sugar to a whole new level as well and lower it to where it needs to be. And here's the great news is that these betas, they're called beta cells on your pancreas. There are certain types of cells that have these insulin receptors, right? That, that, that allow to help bring sugar inside the cell. You can repair those. You can heal those. You know, I had a patient actually had a couple. They were both professors in Nashville. Uh, we have a lot of great schools here in Nashville, Vanderbilt, Belmont, Lipscomb, Middle Tennessee State.
15:28There's a lot of great schools here. And they were both professors. They were both around 60 years old. And they came into my practice. I want to say he was about 60 pounds overweight. She was about 30 pounds overweight. And they'd been on type 2 diabetes medications for, she'd been on it for 10 years. He'd been on it for 25 years. And they just said, hey, we want to get healthy. We feel like we want to start aging well. And we reversed both of their type 2 diabetes off A1C levels, completely normalized, reversed it. For her, it took 40 days. For him, it was like 60 days. Completely off their medications.
16:04And by the way, I've seen this over and over again. I've been able to help thousands of patients completely reverse their type 2 diabetes, and some of them in as little as two weeks, complete reversal off their medications. You can do it. Your cells can heal and heal quickly. Certain cells heal faster than others, certain organs heal. Those insulin receptor cells heal very quickly. Your bones take a little bit longer to heal. Your brain tissue, your nerve tissue is probably the slowest healing, but those cells heal quickly. If you have insulin resistance or type 2 diabetes or prediabetes, you can absolutely reverse it in most cases in 30 days.
16:46At the very max, most people can reverse it in 90 days. Complete reversal if you do the right things. One of the most important things to do, by the way, when you want to reverse insulin resistance is lose weight. A Yale University study revealed that a 10 % weight loss significantly reduced liver fat and reverse insulin resistance and type 2 diabetes. Weight loss itself is the strongest predictor of improving insulin sensitivity, whereas weight regain significantly predicted reduced insulin sensitivity. So your body weight, if you're storing onto much body fat, that is the single biggest predictor of insulin resistance.
17:27Now, that's not to say I haven't had patients I've worked with that came in that were the term that is oftentimes used as skinny, but fat and where your body is holding on to this body fat, even though you're fairly, you know, you might look skinny in the upper body, but you're still holding on a fair amount of body fat in your midsection. I still have had plenty of people that have been lean who have had insulin resistance in that way. But again, the single biggest thing to fix this is losing the excess body fat. You know, the most common medication prescribed for type 2 diabetes or insulin resistance is metformin.
18:03I want to say, though, that metformin does not come without major side effects. One of the side effects of metformin is that it depletes your body of vitamin B12 and numerous other nutrients. And so when you're taking this drug, your body is losing more B12 and more B12 and more B12 and a number of other B vitamins and nutrients. You know what's so crazy to me? There are even prominent doctors that you would recognize that are in the medical space who talk about longevity. and they themselves have promoted metformin, taking it like a vitamin, a longevity drug. And the reality is these people are highly unaware of the nutritional deficiencies it's causing.
18:48And so if you ever see a doctor saying, you should take metformin, it's a good longevity drug. Listen, I'm sure they can pull up a research study to show that metformin supports the body in some area. And maybe even with a group of people where they're severely diabetic, It will increase their longevity. I'm absolutely certain that there are research studies because I've seen those research studies myself. But the reality is, if you're comparing taking metformin to instead taking the supplements I'm going to hit on in a minute and changing your diet, that's the cure. Doctors should be sued for malpractice.
19:24If you come into their clinic, they prescribe metformin, and that's all they do. That's malpractice. Okay? It's violating the Hippocratic Oath. If it's first, do no harm, you're harming them and you're not doing the best thing for them. The first thing you should do is put them on a very specific diet, high in protein and fiber. You should give them the nutrients they need. If you're going to give them metformin, at the very least, also give them the nutrients along with the probiotics for absorption so their body doesn't become deficient while taking this medication. But that never happens. You know, there was a study, it's called the Diabetes Prevention Program that found that diet and exercise achieved nearly twice the risk reduction for progressing of type 2 diabetes compared to the medication metformin.
20:07So we have very clear evidence and data that diet recommendations and exercise are double, far, far more effective than the medication metformin. And they also don't have the serious side effects that come along with it. Do you have unexplainable illness, hormone dysfunction, weight loss resistance, brain fog, and you're tired of being dismissed when you know something isn't right? Well, get my at-home testing of targeted biomarkers, including hormones, thyroid, and metabolism, plus a full hour with one of my senior health advisors to help you understand your results. The truth is your doctor is probably reading your blood work all wrong.
20:48They're missing the cellular issues behind the symptoms. This new testing flips the script. The future of interpreting test results is here. I'm currently offering a simple at-home blood test that actually tests for the right things. And just as importantly, it comes with proper interpretation of your results. If you want to check it out and grab one before they're gone, just go to mybloodwork.com now. Now, I want to revisit fasting. And I do think being aware of how much we eat and not overeating is important. But I think the biggest thing is more protein and fiber. Remember, protein, fiber, protein, fiber, protein, fiber.
21:25And you're going to get that from organic meat, vegetables, and high fiber fruits like apples, berries, and pomegranate. Okay, those are the absolute best there for you to be eating on a regular basis. And then maybe even some things like walnuts on occasion, right? So that's kind of the ideal there of what you should be consuming. Fasting can have its benefits. I would say if you are a woman and want to fast, then I would recommend fasting one day a week and not every day. Maybe you skip breakfast and lunch one day a week and then you eat dinner, but not overdoing it. Remember this, fasting is a type of stress on the body.
22:01And if you're already very stressed, let's say you have a condition like hypothyroidism or chronic fatigue or PCOS, your body's already stressed. Adding another stressor to it every day is going to be just far too much. This is another reason why for women, I'm a huge fan of infrared sauna. I'm not a fan of cold plunge, okay, if you're sick and ill. Men, I think, can do better with cold plunge long-term. Just remember, women and men, your bodies are different, okay? Women, sauna, sauna, sauna. Amazing for your body doing infrared or a regular sauna. Do that instead. Men, fasting in a little cold plunge, not too much, by the way, but a little bit, maybe a day or two a week.
22:41That's great for you, okay? but you want to really, for women, get in the sauna. Men, you could do cold plunge and you could do sauna. And men, you can do fasting as well. Women, if you're going to fast, do it like the early church did. They took one day a week and fasted. And maybe it's just breakfast or maybe it's breakfast and lunch. You spend that time in prayer. But you wouldn't want to do more than that for most women. Now, one other thing I want to mention, and this is important, is the amount you eat and the time of day matters. There's an ancient Chinese medicine, which of course is, this is a lot of what's inspired Japanese medicine today.
23:16We talked about this earlier. Japan is one of the two healthiest countries in the world, greatest longevity, lowest rates of insulin resistance. So what are they doing over there? Well, they were inspired with Chinese medicine, Kampo. That's part of their medical system over there. And they say this, eat like a king for breakfast, a popper for lunch, and a peasant for dinner. So basically they're saying, having a big breakfast is great. Your body can handle it. That's when your digestive system is the strongest. You just got off a fast. Lunch, eat a moderate meal. Dinner, eat a small meal. Now, whether, you know, I tend to do more of a, you know, I eat my bigger meals at breakfast and lunch and try not to eat a real big dinner.
23:57I eat dinner. I eat until I'm 70 % full. Then I stop. Okay. Studies have shown that if you ate a big meal at 8 a.m. versus a big meal at 8 p.m., it impacts your body very, very differently. Okay. If you eat a big meal at 8 p.m., you are much, much more likely to store that as fat and for it to cause insulin issues than if you had your big meal for breakfast. So just remember that, okay? That the time of day, what you eat at what times matters. Again, remember, more carbs in the morning, less carbs at night, more fat at night, okay? And high protein throughout the day. That's the key to healing.
24:34Now let's talk about exercise, sleep, and stress before we get into the supplements. Both resistance training and aerobic activity significantly enhance insulin sensitivity and glucose disposal. On the other hand, stress and sleep deprivation elevate cortisol, which, listen, here's what happens. When cortisol goes up, insulin-resistant goes up, okay? And so stress, being in a fight-or-flight state all the time, causes that insulin-resistance issue. Cortisol is this master hormone that sort of causes every other hormone in your body to get imbalanced. This is why having a practice of gratitude, spending time in prayer, meditation, having good sleep hygiene, right?
25:18When you're at night, not being on your devices or on TV. Again, maybe you stop that at 7 o 'clock or 8 at the latest, and then it's one to two hours before bed. You're reading a book, connecting with family, spending time in prayer, reading your Bible, personal growth book, or just a novel for fun, that's what you should be doing at night, okay? It's gonna help you get better sleep. That's also gonna help your blood sugar and your hormones. There was a study done on exercise. This was published in the Journal of American Medical Association in 2010. And they found that patients with type 2 diabetes found that a combination of aerobic and resistance training lowered ABA1C levels more than either alone in the control group.
25:59So the reality is you wanna do both weight training and aerobic training. Now, here's the ideal. And I remember reading a medical study years ago on this of what had the biggest difference. The ideal is, let's say if you could work out one hour, three days a week, okay, one hour, three days a week, or even 45 minutes, three days a week, something like that, okay? What you'd want to do is start off with the first two thirds or or so, or three, four should be weight training. And then the last bit should be cardiovascular exercise. Okay. So like, here's what it looks like for me. Like I went in this morning and I'll pick a few body parts and let's say I work out more than this, but if I did three days a week, one day I would do legs, uh, in core.
26:44Another day I might do back and chest. Another day I might do arms and maybe more intense cardio or something like that. And then what I'll do. So if I go in, I'll do 45 minutes of weight training. And then my last 15 minutes, I'll do aerobic cardio or I'll do a five minute warmup and it'll end with 10 minutes of cardio. Okay. Some sort of ratio like that, where you're doing at least a little more weight training than cardio. That's the ideal for you losing the most amount of weight in the most instant resistance. And when you do your cardio, it's best to do some of those intervals where you're going hard one minute, easy for a minute.
Read the full transcript
27:17Like I use a Peloton bike. I love using the Peloton. I have no financial connection. I just, My wife and I enjoy having the trainers there and doing it like that. We have a bicycle. I'll go out and cycle around the neighborhood. I swim as well. And I also get on one of those inclined, those curved treadmills. And I will run on there as well and do intervals. Okay. That's the sort of cardio I do. And in the studies show that a combination of weight training and with weight training, you want to work your bigger muscle groups. You want to work your butt, your hamstrings, your quads. You want to work your legs and butt the most.
27:49And then after that, your back. Okay. your back, your chest, your shoulders, that's going to move the needle the most. So working those big muscle groups combined with the interval cardio, that's the best for your blood sugar. And there was one large scale study published in JAMA in 2011. And what they found was this was done on over 8 ,530 patients. The benefits were those who exercised about 150 minutes per week. So that's about working out for at least, this is at least you want to do 45 minutes, three days a week. Those people, when they combined it with diet, saw tremendous results at reversing type 2 diabetes, balancing insulin, reversing PCOS, any and all of those conditions.
28:32Another thing I do want to mention is there's so many studies on sleep deprivation. It is so bad for you. You need eight hours of sleep a night, eight hours. A study published in The Lancet found that restricting sleep to four hours for six nights in healthy men caused a 40 % reduction in glucose tolerance, mimicking pre-diabetic levels. So losing sleep, not getting sleep is really bad for your body. Get good sleep for hormone balance. And then the last reality is this before we dive into the herbs and supplements. Your mindset matters. There was a study on this five systemic reviews and amended analysis found that mindfulness interventions, gratitude, prayer, reading your Bible, meditation, modestly improve your A1C levels and reduce stress, depression, and anxiety with people with diabetes.
29:23So it makes a difference as well. Having these good practices that help lower cortisol, improve your mood, give you purpose, this helps heal your body as well. If you're constantly tired, gaining weight for no reason, or feeling mentally foggy, these could be signs of a thyroid issue like hypothyroidism or Hashimoto's. The good news is there are natural ways to support your thyroid through the right foods, herbs, nutrients, and daily habits. And if you or someone you love is struggling with thyroid problems, I've created a free resource just for you. You can head on over to draxthyroidclass.com to discover practical steps you can take today to start healing your thyroid naturally.
30:06That's draxthyroidclass.com, Your journey to better energy, focus, and healing starts now. Now let me walk you through the supplements and herbs that most improve insulin resistance and help heal and reverse diabetes, including prediabetes. Number one is berberine. Berberine is a compound that is found in bayberry leaf, Oregon grape, and golden seal. And it's a plant alkaloid with effects similar to metformin without all the side effects. It helps fasting glucose and improves your A1C levels. It works by activating something in the body called AMPK, activated protein kinase pathway, which enhances insulin sensitivity, regulates glucose, and promotes longevity.
30:57And what I find such a shame is that doctors are still prescribing metformin when berberine is more natural and equally impactful on the body. But if you've got blood sugar issues, number one herb, berberine. By the way, berberine also has some antimicrobial benefits, and it can be great for treating candida as well. Now, how you want to take berberine is typically 500 milligrams three times daily for three months. That's about what you want to do. 500 milligrams three times daily for three months and see where you're at. In studies, there was a reduction in A1C levels by an average of 0.9 % similar to the effects of metformin.
31:34It's very, very similar in its effects. Number two, vitamin D. It lowers insulin resistance. One study found that vitamin D deficiency was observed in 48 % of patients with type 2 diabetes. And remember, again, vitamin D is also a prohormone. Many, many benefits there for your metabolism. Here's another one that's sort of underutilized in America today. but this is one of the number one remedies in all of Asian medicine for blood sugar, and it's called mulberry leaf. It's been shown to slow carbohydrate absorption, reduce post-meal sugar spikes. There was a study done on 37 individuals, and they found that at doses of around 250 milligrams and significantly lowered post-meal blood sugar by around 33%.
32:20So loads and loads of benefits there. Mulberry leaf. I do that as a powder. It's almost like a green tea matcha, like a little bit of that flavor, but you can buy it in capsules or do it as a tea. But mulberry leaf's amazing for your blood sugar. Jimnema Silvestre. This is known as the sugar destroyer in Ayurvedic medicine. So this was one of the number one herbs used in Ayurvedic medicine for balancing blood sugar. And it's the number one herb used in India today for blood sugar. So gymnema is a great option as well for blood sugar. Number five, now this is a trace mineral that I love, and I would put it up there as maybe number two behind berberine for me in terms of what's the most effective for blood sugar, and it's chromium or chromium picolinate.
33:04This enhances insulin receptor binding and improves your blood sugar. A randomized trial on 180 people with type 2 diabetes found that chromium picolinate supplementation of doing around 1 ,000 micrograms a day significantly improved A1C levels, fasting, and two-hour glucose compared to control groups. Also, it improved cholesterol. So many, many benefits there. So if you're like, what are the top two things I could take, period? Berberine and chromium will make the biggest difference on your blood sugar. This is what I found in my clinical by working with a lot of patients. And not to say that gymnema isn't amazing, vitamin D isn't amazing, but I I think those two are the biggest needle movers.
33:46Another one that can be important for blood sugar statistically, according to studies, is magnesium. Magnesium is just responsible for so many functions of your cell that if you're deficient, it's going to cause you to have insulin resistance. And so it's not typically as effective as chromium or berberine or even the others, but it has been found to be deficient in people in study after study. Another big one, this is also used in Ayurvedic medicine, is fenugreek. Fenugreek improves blood sugar. Now, in Chinese medicine, it's known as a yang booster. This is also good for testosterone. It's also good for breast milk production for women because it's more anabolic.
34:27It helps your body better regenerate. But there was a study done, and they found that fenugreek lowered blood sugar, lowered LDL cholesterol, and also supported testosterone levels. Also, it's observed that the controls had a 2.5 times higher chance of developing diabetes compared to subjects in the fenugreek group when we look at studies. And so fenugreek is another favorite. And then one of my absolute favorites, this is maybe number three for me, if we're ranking them under berberine and chromium, is cinnamon, and specifically Cylon cinnamon. It's been shown to improve blood sugar as well. There was a meta-analysis where they combined 24 different clinical trials, and they found that cinnamon supplementation significantly lowered fasting blood sugar, A1C levels, and insulin resistance in people with type 2 diabetes.
35:16Now, the way that I like to add cinnamon to the diet is just do that as a powder rather than a supplement. And so here's the smoothie. I want to share this. I had another patient who reversed her type 2 diabetes, and she reversed it in 30 days. Literally 30 days was completely off her medications, and she'd been on it for about 15 years. And she was severely overweight. She was obese. uh she lost it was amazing i mean she lost like 50 pounds in in in three months lost 50 pounds but even within her first 30 days she started doing something where she would add in uh she did almost a full tablespoon of pumpkin pie spice a day or cylon cinnamon a day so she would do this smoothie in the morning that included uh half a can of pumpkin so she just did some canned pumpkin She would do 40 grams of protein powder.
36:04She would do 40 grams, 20 grams of collagen, 20 grams of plant protein. And she would just do a big old teaspoon of Cylon cinnamon. And she completely reversed her diabetes in 30 days, her type two diabetes and insulin resistance. It was amazing. And cinnamon was like her number one go to. And it's something that I had her do. I have all my patients do that with insulin sensitivity is loads of cinnamon. And ginger is also very good, by the way. So that's why pumpkin pie spice is a really good mix to add in there as well. But her diet, again, here's the deal. If you want to reverse type 2 diabetes, here's the biggest things in ranking order.
36:42Number one, your diet. Protein and fiber, protein and fiber, protein and fiber. Stay away from refined carbs, ultra processed foods. Stay away from this stuff. Meat, vegetables, high glycemic fruits like pomegranate berries and apples. Okay. If that's your diet predominantly, maybe you do a little bit of sweet potato too, pumpkin, butternut squash, those types of things. Some healthy fat like avocado, coconut oil, extra virgin olive oil. If that's the basis of your diet, that is going to go such a long way. That's number one. Number two is exercise. Okay. Three days a week, do a combination of weight training and interval training.
37:17And if you just can't do that, then walk and walk and walk. Okay. Especially up and down hills where I waited best, but walk more. Okay. And then the number three thing that can make a difference is these supplements. I would recommend berberine. I'd recommend chromium. You can take any of those others as well, but those two at the very least. And then loads of cinnamon in your food or pumpkin pie spice. And if you can do that, you can reverse insulin sensitivity very quickly. Now, I do want to mention there's a few others I really like. I do like alpha-lipoic acid. That would be the other supplement I would add to the list.
37:47It's an antioxidant that supports insulin signaling. And then if a woman also has PCOS, which if you do everything I just told you, the PCOS will be improved dramatically and very quickly. But inositol, I really like as well. And it's useful for balancing those hormones if you have PCOS there as well. So remember this insulin resistance is incredibly common. Nearly 40 % of Americans are insulin resistance or pre-diabetic, yet 80 % of people don't know they have it. but it is completely reversible without medications. Diet is the central exercise and supplementations are also critical at supporting the body.
38:30But remember, if you follow the advice I shared with you, you can see incredible results. Remember also, Hey, good, good sleep, have fun, keep the stress low by doing things you love to do. And if you follow this advice, you can reverse it incredibly quickly. And remember, there are so many conditions that are insulin related. So if you're struggling with obesity or just being overweight, you're five to 10 pounds overweight, that's insulin issue. If you are having low energy, like your energy is up and down and up and down all the time, okay? Heart disease, PCOS, risk of Alzheimer's disease, oftentimes cancer, non-fatty liver disease, all of these issues have an insulin component.
39:10So if we can fix insulin, your body can heal and it can heal very, very quickly. I want to say thanks so much for tuning in here to the Dr. Josh Ack Show. Remember, each and every week we're diving deep into the science and principles of how you can heal physically, mentally, spiritually, and take your health and your life to the next level. I want to encourage you to subscribe to the show. I know many of you are not subscribed. By the way, the number one thing you can do to support the channel is subscribe. By the way, we could talk about a lot of things on the show that tend to be controversial.
39:40I actually just was interviewing with Gary Brecka and Barbara O 'Neill. And we've got Mark Hyman coming up in the future and so many people. We talk about some pretty controversial stuff. And because of it, sometimes my videos get shadow banned on YouTube. So if you're not subscribed, it may not show up on your feed and you may miss one of our best episodes. So I want to encourage you, make sure to subscribe. And also, there are so many people now that have instant resistance. They don't know it. So thank you, all of you that are on mission with me for sharing this episode. I can't wait to see you on the next one.
40:11We'll be right back.
From the publisher
What if the key to reversing diabetes, losing weight, and boosting your energy isn’t medication, but your metabolism? In this episode, Dr. Josh Axe breaks down the real science behind insulin resistance and the daily habits that can reprogram your body for better blood sugar control. Discover simple, research-backed strategies to reset your metabolism, improve energy, and transform your health from the inside out.
Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe
🎧 Early Access!
Our podcast listeners get every episode early, and you can tune in and be a part of our exclusive listeners below →
Spotify: https://bit.ly/DrJoshAxeSpotify
Apple Podcast: https://apple.co/3JDvWcS
Pre-order my NEW BOOK, The Biblio Diet → https://bit.ly/4oPEP3t
Watch my free training on how to naturally balance your blood sugar and reverse your symptoms →http://DrAxeDiabetesClass.com
Discover practical steps you can take today to start healing your thyroid naturally → DrAxeThyroidClass.com
If you’re ready to start feeling like yourself again and balance your hormones, take my free class → DrAxeHormoneClass.com
Uncover what’s really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! → http://MyBloodWork.com
CONNECT WITH DR. JOSH AXE
Instagram: https://www.instagram.com/drjoshaxe/
Facebook: https://www.facebook.com/DrJoshAxe/
TikTok: https://www.tiktok.com/@thedrjoshaxeshow/
X: https://x.com/drjoshaxe/
LinkedIn: https://www.linkedin.com/in/joshaxe
Website: http://thehealthinstitute.com
Sign up for my newsletter: https://bit.ly/4oE9Jf3
Ask me a question: http://speakpipe.com/drjoshaxe
https://www.who.int/news-room/fact-sheets/detail/diabetes
https://www.cdc.gov/diabetes/php/data-research/index.html
https://idf.org/news/new-diabetes-estimates/
https://nypost.com/2025/01/23/health/weight-isnt-the-only-factor-driving-diabetes-risk-3-other-drivers/
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829479
https://www.nytimes.com/2023/10/03/well/live/insulin-resistance-signs.html
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1646258/full
https://pmc.ncbi.nlm.nih.gov/articles/PMC5990470/
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-021-00613-9
https://pubmed.ncbi.nlm.nih.gov/31105044/
https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.023817
https://pmc.ncbi.nlm.nih.gov/articles/PMC8970877/
https://time.com/6188405/type-2-diabetes-intermittent-fasting/
https://www.nature.com/articles/nutd201731
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1325894/full
https://www.cdc.gov/diabetes-prevention/hcp/lifestyle-change-program/index.html
https://www.sciencedirect.com/science/article/abs/pii/S2213858719300683
https://diabetesjournals.org/diabetes/article/46/11/1786/10196/Elevated-Intakes-of-Supplemental-Chromium-Improve
https://jamanetwork.com/journals/jama/fullarticle/186960
https://jamanetwork.com/journals/jama/fullarticle/899553
https://pmc.ncbi.nlm.nih.gov/articles/PMC2857625/
https://pubmed.ncbi.nlm.nih.gov/20371664/
https://pmc.ncbi.nlm.nih.gov/articles/PMC10534311/
https://pmc.ncbi.nlm.nih.gov/articles/PMC2464622/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11174565/
https://pmc.ncbi.nlm.nih.gov/articles/PMC7230589/
https://pmc.ncbi.nlm.nih.gov/articles/PMC12393874/
https://pmc.ncbi.nlm.nih.gov/articles/PMC4591578/
https://pmc.ncbi.nlm.nih.gov/articles/PMC4591578/
https://pubmed.ncbi.nlm.nih.gov/37818728/
Learn more about your ad choices. Visit megaphone.fm/adchoices




