In short
Joe Lonsdale (8VC) argues that AI is compressing decades of progress into the next few years, and that investors should back “agentic” founders and productivity-focused AI—while also addressing public skepticism shaped by social media incentives. He also discusses defense/AI policy debates (Department of War vs Anthropic), healthcare AI sandboxing to cut costs, and biotech/robotics/energy investment themes.
Guest backgrounds
Joe Lonsdale is a founder/investor who co-founded Palantir and Addepar, served as chairman on OpenGov, and runs 8VC. He has invested in defense and biotech supply-chain efforts, and has long focused on large-industry execution.
Key claims
Building is extremely hard; investors should only do it if they’ve been all-in founders. AI’s biggest near-term grail is productivity and moats from top technologists. Social media polarizes and reduces trust in AI. AI can make healthcare cheaper (e.g., primary-care workflows via AI sandboxes). Defense AI decisions must be made by the Pentagon, not company CEOs.
Notable examples
OpenGov sale for $1.8B; Palantir’s workflow ontology and “FTE motion”; Utah allowing AI re-prescription workflows; Oracle layoffs; Joby Aviation efficiency gains; primate-testing supply-chain company for safer human medicine; investments across energy (nuclear/uranium), chips, and robotics (AI-driven excavation).
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VOThe Mindset of a Founder and Investor
0:32 to 2:32
Joe discusses the challenges and mindset required for building and investing in companies.
“One of the things I want to start with is I kind of put you in this category of people who are both investors and founders, like the real way, you know, like a lot of people say that, but you really have done it.”
Contrarian Views on AI and Entrepreneurship
2:32 to 4:24
Joe shares insights on the current AI landscape and the importance of productivity.
“You'd much rather back a really competent person who they themselves are already all in, you know?”
Palantir's Role in AI and Workflow
4:24 to 6:26
Discussion about Palantir's contributions to AI and how to apply technology effectively.
“And so I just need to go do it better than everybody else.”
Productivity and Future Industry Insights
6:26 to 7:20
Joe explores how productivity will shape industries by 2035 and beyond.
“When you say Palantir figured out a lot of the modes of how AI is working, what else?”
Cultural Impact of AI and Social Media
7:20 to 9:38
The conversation shifts to societal perceptions of AI and the negative effects of social media.
“And that means we're taking the 2050s and 2060s and going to put them into the end of the decade and the start of the next decade.”
Building Trust in Technology
9:38 to 14:00
Joe emphasizes the need for a positive narrative around AI and a collective effort to improve its perception.
“I feel like tech probably lost a decent amount of trust with the public as a result of social media and people being like, you know, they don't care.”
The Impact of Social Media on Democracy
14:00 to 15:00
Discusses how social media negatively affects democracy and children, especially young girls.
“I think social media has had a terrible impact on our democracy.”
Optimism and Wealth Creation through AI
15:00 to 17:00
Explores the potential for AI to drive productivity and wealth growth over the next 30 years.
“I think it's gonna be like four or five times wealthier the next 30 years if we allow this to work.”
Healthcare Transformation with AI
17:00 to 19:30
Discusses how AI can make healthcare more affordable and efficient through innovative legislation.
“And so I think there's a little bit of that.”
The Role of AI in National Defense
19:30 to 22:30
Analyzes the nuances of AI in defense, addressing the ongoing debate and implications for the military.
“He does believe America is better than CCP.”
Show all 23 chapters
Navigating Ethical Dilemmas in Biotech
22:30 to 24:10
Considers the ethical implications of using primate testing in biotech research amidst public sentiment.
“it both means you're playing in a space that other people aren't playing, but it also reflects a personality type that has like a very...”
The Future of Robotics and AI Integration
24:10 to 26:40
Discusses the challenges and potential of robotics and AI, emphasizing the importance of AI in advancements.
“That thumbnail will get us a lot of clicks.”
Breakthroughs in Bioinformatics and Drug Development
26:40 to 28:00
Explores the intersection of AI and bioinformatics in accelerating drug development and understanding proteins.
“being yelled at who has to earn his stripes for 20 years.”
The Future of Robotics and AI in Bio
28:00 to 29:00
Explore the intersection of robotics, AI, and bio technology, focusing on advancements and impacts.
“I'd be surprised if we don't have some really cool robotics companies by 2040, right?”
Investing in Quince and Lessons from Wish
29:00 to 30:30
Discussion on Quince's success, lessons learned from Wish's downfall, and a redemption narrative.
“I mean, I guess other stuff we're doing, just like, just like competent people at execution.”
The Energy Landscape and AI Investments
30:30 to 31:55
Insights into energy investment strategies, the importance of energy for AI, and market trends.
“these 200 guys and there's all this really complicated tech stuff to explain that we're doing and how it works and how hard it is.”
Navigating the Venture Capital Landscape
31:55 to 33:10
Understanding the current venture capital environment and the importance of youth and innovation.
“Looking around like the venture market now, you've obviously been doing this for a long time and we're in like a kind of chaotic moment.”
The Role of Youth in Tech and AI
33:10 to 35:40
Emphasizing the advantages of young talent in tech and the evolving dynamics of talent acquisition.
“What do you think is either the sort of structure of firm or individual that is best equipped to succeed right now?”
The Impact of Peptides on Health
35:40 to 37:20
Discussing the rise of peptides in medicine and their potential market implications.
“What do you think about all those peptides?”
Cultural Perspectives on Tech in Texas
37:20 to 39:40
Reflecting on how living in Texas influences perspectives on technology and societal issues.
“And so I think it's more of like a policy has been holding it back as well.”
Political Insights and California's Challenges
39:40 to 42:01
Discussing political dynamics, economic challenges, and the need for reform in California.
“we really probably should be doing a better job marketing some of these things for our country and coming across in the right way and respectfully to people.”
Challenges of California's Environmental Regulations
42:01 to 42:49
Discussing the complexities and inefficiencies of CEQA and its impact on development.
“Sironics building there, all these companies are building there.”
The Need for Leadership and Courage
42:50 to 43:04
Highlighting the importance of courageous leadership to address systemic issues.
“We need the leaders to actually win and we need people to wake up and actually fight for it.”
Transcript
Automatic transcript. May contain errors.0:00If you like took like the normal path without AI and like things we were building and knew we needed to build and like assume we need to build, we're like taking the 2030s and 2040s, we're like packing them into the next two or three years because so much is happening right now. Yeah. And that means we're taking the 2050s and 2060s and going to put them into the end of the decade and the start of the next decade. It's just like so much cool stuff.
0:22All right, Joe, I've been really looking forward to doing this with you. You're one of the most interesting people to me and I love a lot of the work that you've done. And so really excited to chat and learn with you. Thanks for having me, Jack. One of the things I want to start with is I kind of put you in this category of people who are both investors and founders, like the real way, you know, like a lot of people say that, but you really have done it. You've like started many companies. You've you've started companies that you then become chairman and some you've worked for a long time on. Obviously, there's Palantir, but there's like there's many others.
0:51Then you also have your own VC firm. I'm just sort of curious, like, what's the mindset that you approach company building, company investing with? Where do you start when you think about doing your work? Well, I think starting a second or a third company is fundamentally sort of an insane act after you've been successful because you already obviously have the money you need. So what are you doing? Because these things are so hard. You almost have to convince yourself every time that it's not going to be as hard as last time, even though you know it is. I mean, I did it once then. I remember it.
1:18I'm like, that's too hard. It's like really, really hard. But you just keep doing it. Well, I did like two where I was CEO, Palantir and Adapar. And then I did a few where I was chairman and like really in the weeds with OpenGov. I was with Zach last night, who was my CEO at OpenGov, who did very, very well. He sold it for$1.8 billion after like 14 years. It was like paddling through the dirt, I was saying. It's like so freaking hard, especially compared to these things today. Like an AI founder who's just like at$100 million in no time. We were next to this kid last night who I'm backing who's like, Joe, I'm not just doubling.
1:48I'm tripling revenue this quarter. because it was just like it was so hard getting these things to work. A hundred million used to be like eight years of hard work where basically everything went right. Yeah, now like one of these kids who worked for me has a billion in revenue and a third year like screw these kids. I love it. I'm investing in them. They're great kids. But it's like they're great. You're adults. You're calm. But no, listen, I think like building is really, really hard. There are just gaps in the world that I see. It's just how my mind works. And there's like this is a gap. And there's like people who are hurting because of this gap.
2:17There's things that are broken because of this gap. and it's so broken and no one else is fixing it. And I have all these really smart friends. Let's go fix it. And so I just can't help that instinct to like just go fix things. We say at APC, like the world is broken. Let's fix it. That's just my energy. So if no one else is going to do it, fine. Let's get people together and do it. But it's like the last option. You'd much rather back a really competent person who they themselves are already all in, you know? Yeah. Do you think not enough investors have this instinct? Like do you think it's right that most people don't do it?
2:44Or do you think there's actually, you know, more investors who can and should, you know, understand this is an interesting setup, just like get some balls moving and then you can attract people to it? Or do you think it's like, right? I think if you haven't yourself gone all in and built a startup and gone through the pain of that over years, then you probably have no idea how to actually build a startup and you just shouldn't be doing it. And I think the first time you do it and probably the second time you should just be 100 % all in and you shouldn't be distracted. So I think I'm like a really bad example for people.
3:11Like you actually shouldn't try to do these things at all. It's funny because even among investors who were former founders or who have done it before, I think many just don't take that as one of the options of actually I could just get this thing started, work with somebody, build around it. It takes a lot of energy. It's like you have to pour like a piece of your soul into something to really make it. Not that I do this right every time. Like I make new mistakes all the time, of course, but like every once in a while. And frankly, like the last several times I've been involved, it's not really mine.
3:39It's really like I'm helping assemble the founding team. I'm helping bring together lots of talent. and how I've been together with a mission, I'm giving them enough upside that it's theirs. And then so that's a little bit different than doing it yourself, obviously. So it's going to be a spectrum, you know? Yeah, totally. I'd be curious to hear a little bit about how you're feeling in this general moment. You know, we were just talking about how hard it used to be to build companies to 100 million of revenue. Now these like AI companies are going nuts. So fast. It's like so fast. You strike me as like, you know, kind of like in the sort of Peter Thiel contrarian-esque mindset of things.
4:09And one of the things that, you know, I wonder is like, is it uncomfortable in any way when the whole world sees something and you're like, we might be in that the quadrant of the two by two that is both like contrarian and right? Like, are you kind of in the mindset of like, AI is actually the thing. Most people have it right. And so I just need to go do it better than everybody else. Or do you sort of take the view of, well, when everybody's here, I should actually be, you know, spending my time here because there's going to be a new wave by 2030. You could still make a bunch of subquadrants, and they could be wrong in some things, and you could be right about some things, but you're all inside the big AI is right thing, right?
4:44It's not like you just have this super simple model. But yes, obviously, this stuff is working in lots of ways in AI. I think people are probably not focused enough on productivity as the kind of grail you should be going after. I think they're not focused enough on the moats created just by the very most talented technologists. So I think going after just the very, very best teams and going after problems that are going to lead to higher productivity. And then there's just all these nuances for how big industries work. And I've been obsessed with a lot of these large industries for a long time.
5:15So I think we have advantages there. But yeah, I mean, listen, it is non-consensus. I'm just like really bullish on this stuff right now. It's just working. What are you going to say? It's all working. Let's go after the very best of it and help it. I can't remember where I heard this, but somebody was saying there is a form of contrarianism even among good ideas, which is that you can like believe harder than everybody else. You believe more. You can understand more the nuances of what's working. So the thing, listen, I've got really lucky the last few years because I get no credit for like Palantir figuring out what it did the last five years.
5:47The only credit I get is that I actually like originally like built the company. I did hire a bunch of those people who are in charge. But like, but it's them now who've done it recently. But like the stuff that we figured out at Palantir and the stuff they figured out at Palantir turned out to be relevant to a ton of other AI companies. So it's kind of the center of the AI world in terms of what's working in many ways was right around Palantir. And so that's just a huge advantage for us. And I think we understand a lot of the nuances. Like how do you apply a workflow ontology to this area? How do you apply the FTE motion to this thing and go deeper on this with a SaaS plus FTE?
6:19It is interesting. The FTE thing is just everywhere now. I mean, it's almost memetic, but it's true. And Palantir figured out the way you do these things in the AI world. And yet you have to use that. When you say Palantir figured out a lot of the modes of how AI is working, what else? Besides that FDM, what about the technology itself? Well, it's like how do you extract the ontology of the workflows? And how do you figure out where to apply LLMs and where not to apply LLMs to? And then what do you have to build for it to work? And there's just a lot of stuff that people have got it right. When you talk about like the productivity stuff being like sort of like underexplored and people don't appreciate how important it is, do you mean like areas of like productivity software?
7:01Are you talking about like making individual like professional workers more productive every day? Is it both? Like what are you thinking about? No, it's definitely both. It's also just like how should this industry work in 2035? Like what does this industry look like today? And what does it look like if it's doing everything that's possible that we know is likely to become possible? It's like unmet. What matters? 2035 seems like – It's so far away now. I can't even think about like May. No, I know. It's like we're pulling, if you like took like the normal path without AI and like things we were building and knew we needed to build and like assume we needed to build, we're like taking the 2030s and 2040s and we're like packing them in to the next two or three years because so much is happening right now.
7:38Yeah. And that means we're taking the 2050s and 2060s and going to put them into the end of the decade and the start of the next decade. It's just like so much cool stuff. My favorite one this week, every week there's something. My favorite one this week is I was with the guy who runs Joby Aviation. I was actually doing an episode with him. And it's just like it turns out there's just going to be all these ways that jets and airplanes are going to be like 10 or 20 times as efficient in the next decade. And like he's launching in the next year, obviously, these current flying cars. But actually, there's like massive things that would take him three months before.
8:07You do it in an afternoon now with his aerodynamicist. It's crazy. Yeah. By the way, it's funny because I feel like before AI took off – or like right at the beginning, like right after ChatGPT, so much of the conversation felt like it was around like you know agi asi and like is this you know is this like sci-fi terminator taking over and then as everything has like become super commercialized and you know these are great businesses and it's proliferating the economy in a weird way feels less sci-fi now and more just like there's just cool things to build there's so much and people underestimate like really smart people like he was saying like his right hand had just like a list of like 50 things he wished he could work on a build and just wasn't the resources wasn't the ability now we're going to get through it all there's just there's so much to build it's working what's interesting is that that mindset though i don't think everybody has it you know and like you can see this actually you know in in high schoolers or something where some percentage of high schoolers i think are like becoming like you know putting on an iron man suit with ai but you can also use ai to just sort of like skate by and so you kind of see these like big skids well it's like it's like soma the sci-fi sci-fi it's a heroine right it's like it's really scary like you can use you can use ai to be your heroine you can use ai to not have to do much at all you can use the i to lose all your agency there's like a very negative version of it and there's like this extremely positive version of it and you know this is a cultural thing we got to figure out how do we get people to be more agentic themselves how do we get people to engage and to choose to get dopamine from iterating and winning and not from sitting there and attaching it to their brains you know it's like a hair like tiktok is evil yeah and i hate that x is having to copy it because the the financial incentive for social media is evil right now yeah no i mean you're saying x copy you know you on x you go into a video you start you scroll you're like it's bad you're on tiktok again i've blocked i've blocked tiktok for years partially because the ccp and stuff but partially because also i don't have the willpower not to freaking scroll these things so i block it i block instagram i can't deal with it yeah and like i'm an investor with elon and x i guess i mean spacex now so maybe it doesn't matter but it's like so i so i have it you know and also i'm addicted to like commenting my stupid views online i'm arguing with paul and g we were today whatever uh he's a good guy but i got angry at him but but like but like but then you go on this thing and it gets addicted to you late at night too it's horrible.
10:10I don't know. I'm going to have to turn it off. It's terrible. Yeah. I feel like tech probably lost a decent amount of trust with the public as a result of social media and people being like, you know, they don't care. Like the tech industry is just like here to like monetize eyeballs and make money off of us. You know what's ironic? It's like, generally market forces are really good in our society. Like they cause us to have to work hard to solve problems. They're going to bring down the cost of so many areas if we can get rid of chronic capitalism in the media itself, like with newspapers and in social media, market forces are terrible.
10:41Yeah. Because it's like because it's because an attention economy, your incentive is to like distract people and just like polarize them. So it's just like that is like the worst area of society for tech. And unfortunately, that's what we're known by. It's really bad. It's also, you know, it's you know, I'm not like some I'm not anti journalist. I'm not, you know, against mainstream media or social media particularly. But, you know, it's like even with journalists who I really like, it's not their fault always, but you know, they might write a great article and then somebody, you know, some editor, the crazy headline on top of it because they got to, they got to grow a business.
11:14It's, it's a very bad incentive and it's actually, it's ripping apart our society right now. And these, these bubbles that it creates in social media, there's probably half your listeners. If they're, if you have a typical listeners who are like, Oh, that Joe Lonsdale guy, he's like, I don't, I don't like him. He has different views than me and he's offense. He offends me. And the other one's like, yeah, you go. And it's like, It's so unhealthy. Well, and the problem is, you know, the middle of the bell curve, who is neutral on Joe Lonsdale, is not going to get shown this because that's not how the algorithm is going to work.
11:39And so I'm going to show everyone who either loves me or hates me. Probably. You know, it's like in general, I think. I'm going over some haters maybe. That's right. Yeah, we'll try. That'll be our goal here. We'll run a survey afterwards. Thank you. I feel like that is probably the problem with social media, though, is it just amplifies extremes. And like a middle of the road, neutral, agreeable take is not incentivized. Yeah, I know. Most people are boring anyway. That's true. No, no, no. Here's the thing. I was on a walk with one of my mentors at the dish just before this. And she comes from the moderate left.
12:08And I don't, obviously. But I actually think like most issues, there's a dialectic where there really is truth on both sides. And what I'm trying to do lately is like actually step back and just like what are the dumb people on each side, but what are the smart people on each side? And I think social media does not do that. Like I wish there was a way for it to do that. So relating this to AI, I feel like the tech industry has some currently missed opportunity to do a better job with our relations to… We need people to love AI more because otherwise we're going to ban it and it's going to hurt us.
12:37And they don't love AI. All society is going to hurt us. I don't think America loves AI right now. Not enough people. Yeah, I think not nearly enough people. They're scared, right? It's understandable. I think they're scared. Why don't they like it? There's a threat for jobs, obviously. And so if you're in an industry where it looks like, you know, you're seeing all these headlines. Do you know anyone personally who's worried about their job being lost? Just to be totally honest. Like, oh, my life's going to be tougher. Because everyone talks about it, but no one knows anyone. Everyone thinks it's not coming for me.
13:01Exactly. I think everybody believes it's going to happen to everybody else. Who are we afraid for? I'm actually really curious. Who's the architect? Because if you walk through it, it's hard to get to the person. You know, what's interesting is we should be, you know, software engineering, let's take as a good example of like, it's probably the best application of AI right now. I just saw a chart that job postings for engineers are going up and are as high as ever right now. There's so much to build right now. And so then you have the question of are we basically just amplifying the value of that function and so there's going to be more demand because it's more valuable?
13:30There will be. Oracle did cut, I think, 30 ,000 or 40 ,000 people because there were things that they had to do with 30 people that have to do with three people now and they just don't have as many of those things to do. So there definitely are already things where you're seeing some cuts for sure. The question is, can those people now in this economy do better? And I think most of them can. But that's been another agentic question we have to ask about. But so then why do you think we're sort of like failing to make AI look like a positive force for the world? Because everyone hates tech from social media.
14:00I think social media has had a terrible impact on our democracy. It's ripped things apart. It's like very distracting for people. It's not good for kids. It's like terrible for young girls especially. I have five daughters and a son and it's like I'm not letting my young girls on social media if just for everything I think it's poison for them And so this is like the last their last consumer experience with us And now that this is like the next social media to them. Of course. They're afraid of it Like I think that's the energy. Yeah, you were mentioning to me before that China likes AI more than America some survey show me it's like 75 or 80 percent positive and we're like 30 percent positive now They may just take better direction from their leaders than we do So that's a cultural question.
14:39But I also think there's more optimistic about how they could build with it and create wealth with it, which people should be here too. I think this is gonna, so the last time we had productivity go up a lot over 30 years, it was like the working class person, the median was like 2.4 times wealthier. There was 1870, 1900. So more than twice as wealthy, real terms for working class. I think it's gonna be more than that the next 30 years. I think it's gonna be like four or five times wealthier the next 30 years if we allow this to work. This is amazing. I think people will start to see, Hopefully, if we don't make it illegal, just what it could do the next five years, I think it's going to be really positive.
15:10It's almost like we need it to proliferate quickly, though. Because to that point, we were just talking about these founders who are having these explosive businesses. You have a lot of people who are resistant to AI. That sounds like the beginning of wealth inequality to me. Well, this is why we have to actually make sure that the applications of AI that help the middle class, that help the working class win faster and make sure they're legal. So right now, for example, like the number one thing I think AI could do for 350 million people in the U.S. is we can make health care like half cost, like really fast.
15:41Like health care should cost half as much and it should be way better. It should be way more convenient. How? Well, there's a bunch of different levels of this, but we need health care services and AI. We need to actually have primary care, work with deterministic AI where you're allowed to start a business that has one doctor and has a bunch of nurses and a bunch of others. And it has input through AI and they optimize it. And they do things through AI that we know are safe. And we prove out, here's 100 different workflows. So Utah just allowed one workflow. They allowed, if you have a chronic disease and you've been prescribed medicine by a doctor, your re-prescription can involve AI.
16:11It doesn't have to involve a doctor. And they're testing it out. So what I'm pushing right now is a healthcare AI sandbox legislation. You know, we have Cistero Institute, which gets things done in like 20 states. So we're trying to get a few states to create an AI sandbox where we can very safely prove out dozens and then hundreds of kind of primary care workflows. and then that would allow huge cuts in costs for these things. And then there's a bunch of other areas of healthcare, of course, he goes after as well. But this is, you generally can have AI practice more safely for a bunch of things where it's actually better.
16:39Yeah. Yeah. I mean, I think there's going to be so many of these. We just have like, there's like a marketing problem right now, it feels like to me. Is that we, well, you guys are the better marketers than me. I need help on that. Well, I don't know either. I mean, you know, like - Let's fight to actually bring down costs for people. That's a good marketing thing. One thing I don't think helps for, you know, and you were close to this, obviously, you know if we can talk about a little bit you know at a high level at least about like the department of war thing that just happened i mean i'm actually interested to hear so you think it doesn't help because i think it doesn't look bad or what no i don't think that i think it's um i think what what it is is um when you have two companies or you know other you know where you see them at odds and you see everybody fighting we're fighting and there's this dynamic of like when you know the pigs roll around in the mud everybody's messy kind of thing and it's just like just a negative energy around like everybody's like telling each other everybody is trying to project that like the other side's terrible you know you know what's funny is that the positive is that it is still being used right now with palantir and anthropic and it's working like really really well this is like the one of the most accurately fought wars with least civilian deaths and the most bad guys falling so fast which is amazing you know so it's like there's all this positive for the u.s if you know what it's like it's like a nasty um it's like a nasty primary election before the general election it is like that you know and it's like hey like there's this sense I have where I'm like, on some level, like, if we all really care about AI getting there, you don't want a really nasty primary before the general.
17:59It doesn't help. It doesn't help. And so I think there's a little bit of that. I'd be curious, like, you know, because you're obviously very close to the Department of War. And so like, you know, with... My friend Emil and then Depsec Feinberg and all these guys in the middle of this. Yeah. And so it's like, you know, with most people in tech, it's like, you know, people, you know, got sort of their tribe to some extent or whatever. And that's fine. We were talking about this ahead of time. That is my tribe, but I was trying to tell you ahead of time that even though I'm on, and I can explain why, I think they're right and Palmer's right.
18:29I actually introduced Dario and Palmer and was trying to get them. I was trying to get them to get on. And it's like how you're saying you appreciate the moderate left and you want to hear the good side of the other side. I think it's really important in this state. If you've heard about the D.O.W. and Anthropic battle and you only think there's stupid people on one of those sides. You have to assume it's smart people who want good outcomes for the world. There's smart people who want good outcomes, who have their good point of view. So my main point of view, supporting the Department of War ultimately, is that you can't have the gray, complicated, nuanced decisions about what's allowed being made by the company or having the company involved in those.
19:04You have to be able to make those nuanced decisions at the Pentagon at the end of the day. And I think that's a fair, totally correct viewpoint. But stepping back, like, listen, originally Anthropic came from like a much more effective altruist. I'd call it very left, very different perspective. And originally they had like, I don't know, like 50 pages of demands for the Pentagon, which were ridiculous. And then to Dario's credit, A, he went and worked with the Pentagon ahead of time, more flexibly. He was trying to help America. He does believe America is better than CCP. B, he got all that 50 pages of nonsense after lots of iteration with his team and lots of work down to just two requests.
19:38And he really has boundaries of why they created Anthropik and what their boundaries should be. And that's in his mind. And he's managing a bunch of co-founders who have different views. you know and they got them all the way there they were working with them they tried really hard but at the end of the day like when they're in the room with the male there's 20 people and and you know the two demands were like no autonomy no surveillance and no surveillance and like and they'll say okay well for autonomy let's say we're going to be using one of palmer's autonomous fighter jets and something we're planning but in the anthropics involved in playing the whole thing is that not allowed or let's say we're using some autonomy in how we respond to an attack and they go, that's the fence.
20:16It's okay. Well, what if we're doing an attack, but then it's part of the attack we're using autonomy to respond to things autonomously. There's all these nuances and Dario's response, oh, just call me. We'll work it out. Just call me. And the secretary's like, well, I can't just call you. I'm in charge, not you. I can't have a CEO making the decision. So, sorry, spec where Dario's coming from, but I think the part of where I had to make the decision I had to make, I'm very sad I got into all the months. I'm very sad about that. no,
20:43there's some way for the industry to just like want to think of it as you know all on a team of you know this is going to be something that's good for the world yeah i think it's good for the world but i think we have to have debates and it's fair to have debates and there's going to be really tough debates about how this is going to be used and you know i think dario is right there are laws congress does need to pass that it has not passed yet because it hasn't even anticipated some of the nuance of like how can you even do surveillance and things with these tools you can never have done before so there so i mean listen there's a lot of good points on both sides here and we're going to have to work together and hopefully our republic can figure out some good rules.
21:14I hope it will. I think it will. On the defense side, obviously you've been involved in a bunch of companies like Palantir, Andrel, Saronic. Yeah, I started Palantir at Saronic and I only invested in Andrel. Only invested. Too bad. And everyone in the early rounds. So those guys are crushing it, man. It's so impressive to see. Three of them used to work with us at Palantir and then Palmer's a good friend. And it's just, yeah, and then Dino at Saronic. He's built more big ships than anyone else now. Fastest built ships since World War II that are big. It's so fun. Yeah, I mean, I wasn't doing venture 10 years ago, obviously, but it seems like there was no interest in this stuff now.
21:47And now outside of AI, it's like the hottest place. It wasn't just that there was no interest. Like when I wrote the check in Neanderthal, I had multiple people tell me they would never work with me again and to not even talk to them about their next round because it's so evil to be working in defense and working on weapons. It was like you had to basically be willing to just go completely against the cultural zeitgeist and be excommunicated, basically. But by the way, sometimes that's the most valuable things to do is when you do stand up to everyone. Well, it is crazy. I mean, Trey wrote something, Trey Stevens wrote something recently that's basically about like, you want to be funding people who are saying the thing that's not popular and not exciting and it's going to be the creation of the next.
22:21I love this. This is one of my favorite things. It's like, what does no one else want to do that is really important to do? Yeah. And by the way, to me, that's like a definition of leadership. It also, like, it both means you're playing in a space that other people aren't playing, but it also reflects a personality type that has like a very... You're willing to just say, you guys are all wrong. Yeah. It's important. Can I give you a crazy one right now that we're doing this working? That's what I want. So China during COVID ended up cutting off a lot of things from us. And they had this whole big strategy of like going after our biotech sector.
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22:49And one of the really key things you need in biotech is to do primate testing. And this is very controversial in the US because obviously you're herding monkeys. Of course. But like my five-year-old daughter, by the way, gets it. I say, if mommy had a very bad disease and we had trying to work on a cure, do you want us to test the cure on mommy? Or do you want to test on the monkeys first in case it kills the monkey? Would you want to know that instead of killing mommy? She's like, she's like, test the monkeys. I'm like, how many? And she's like, hundreds of monkeys. Hundreds of monkeys before mommy.
23:12What's the ratio? It's high. It's very high, right? Because it's mommy. And it's, and actually, but there's like wisdom there. Like, I think human life is more important than, even though I feel bad hurting a monkey. So, so again, you don't test the monkey right away. You obviously are. No, of course you do all these other things first. You try to use, you try to use AI to figure it out, but sometimes AI is not going to know as well as testing it. And so anyway, there's not nearly enough primates now and like no one will touch it. So we started a company to provide safer human medicine. It's called, and we're providing like massive numbers of primates, working with a bunch of biotech firms and we're breeding them here and bringing them over and no one will touch it because they're afraid because that is it sounds scary to do right yeah but guess what would you rather save would you rather save your sibling or the monkey yeah that's a very taboo idea isn't but and it's working we're making tons of money and it's not evil it's like people might say it's evil it's not evil it's actually good it's pro-human well it's funny i think a lot of ideas there's a whole category of idea that sounds really bad when you say a snippet of it yeah this evil man is doing his defense and killing monkeys i mean you hear the whole yeah exactly Can we get that on a headline here?
24:08I failed again. That thumbnail will get us a lot of clicks. That'll be perfect. But there's a lot of ideas like this where they sound bad if you take a certain snippet of them. But if you think the whole thing through, you're like, actually, that is an increase in overall morality. It's really good. That's the type of idea that sounds like it could flip. And it's critical for like bio supply chain. This is like actually something our defense department is even aware of. We need a supply chain for our industry. Literally, I've actually – so we're going to have to do the next round ourselves. I think even though it's crushing it, no one will touch it.
24:38Yeah, that makes sense. Everyone's a coward. Yeah, it's crazy. I'll make all the money myself. But then I guess, I mean, with these defense companies, it's like eventually it flips and then there becomes an insane amount of capital. And there's too much. And there's too much money to love. Then you can't even take all the money people want to give you. So Ronak has like billions and billions of interest for the next round. They're going to crush it. So guys, you know, it's still a great investment here. I don't know a ton about defense in general. Is it a space where there will be like a thousand blooming flowers?
24:59Or is it a space where there will be a small number of companies dominating? There will be like a dozen Neoprimes that will completely crush it. I think there will be that many though. Yeah. I mean there's already probably like eight or nine that are just really crushing it. I think Andrel is the biggest Neoprime and it's going to make the most money. Yeah. And I think Sironic is going to be a massive, massive company. I mean we're trying to 100X our shipbuilding capacity. I think a lot of ones like Sironic are already trying to work not only in defense but figuring out how to work commercially.
25:24And Chaos is crushing it. Epirus is doing really well shooting down drones with microwave. Why can't the incumbent primes catch up on the technology? So what happened was in the 90s is that 80 of these companies merged to become eight primes basically. And then you had the tech wave and all their core tech talent left. And they don't have computer science talent. And they don't understand what computer science talent is. So you've seen this. When you start a really top tech culture, why can't Anthropic be built by IBM? It's like, come on. It's crazy. It's not going to happen. Even easier things than that.
25:59You're like, why can't a 30 billion market cap incumbent system of record, why can't it build one of these applications that 30 engineers at a startup are building, even though they're putting 200 engineers on it? But how do they hire those 30 engineers? How do they give them the upside? How do they have the culture? The engine that we track, I'm sure you guys do too at Benchmark, we track at ABC thousands of talented engineers. We have all sorts of ways of doing it. We try to get them out of what they're doing. and I've been doing this for 15 years. None of them were going into the primes. And the very few that did, they would leave very quickly because they'd be rejected.
26:34They wouldn't get an upside. They wouldn't get the right culture building. They wouldn't get treated the right way. They'd basically be like the kid in the basement being yelled at who has to earn his stripes for 20 years. Why would they do that? These cultures are broken there. And they're not showing any signs of fixing themselves. There's certain things they're good at. They're not doing the other stuff. Yeah. What else are you interested in? I mean, we can talk about AI too and I want to, but outside of AI, what are the other areas? like bio robotics like yeah well everything is like tied back to ai in a way because if you're doing things in robotics like our best we have one robotics investment called bedrock and it's a bunch of guys from waymo with me boris and he's and he's like doing excavation and it's working right so it's ai driven excavation which is 25 of the construction spend in the u.s it's going to change the value of quarries and mines and super cool by the way it seems to me like robotics should be like a bigger category than like software yeah i think eventually i think it'll it might take 30 of years.
27:23None of this stuff works. Yeah. I mean, his thing's working. It's my first big investment I made. Most of this stuff doesn't really work yet. That's the problem. I've looked at hundreds of things, like not personally, but my team and I. Yeah. Don't you just think like Elon will figure this out? You know, like, he'll figure out a big piece of it, I think. And I love Elon and I back. I'm not saying he'll make that there's no other robots available. I'm just saying like, don't you think this, why would this not end up, why would robots not end up working? I mean, no, I think the world models are harder than people think.
27:47It's obviously, and I've backed, I've try to back everything Elon does. I think it just takes longer than even he thinks for some of these things, right? It's just like we can say the estimates are really hard to get right. I don't know what's going to be there by 2030. I'd be surprised if we don't have some really cool robotics companies by 2040, right? It's just like it's clearly coming. Yeah, yeah. What about other things? Like, is there anything in like bio that you're interested in? There's a bunch of stuff going on in bio. But again, like the rate of discovery is just like AI enabled. I think Demis' Nobel Prize was well-deserved, right?
28:17I think we had like 213 ,000 proteins we'd like mapped out. and understood how they work and understood the mechanism of action over like many, many years of hard work. And I think his AI mapped out like a 200 million of them just like all of a sudden, you know, just from figuring it out. And so like we're still in the dark ages of we're just figuring out. Like I saw like a small model the other day with all this biodata. And they were like, how do you make a protein do these two other things to go after this like just like, you know, this disease. And it just like redesigned the protein and figured it out.
28:44And we don't even know why it figured it out, but it did. Like so we're still it's like it's really cool. So it's like, so I mean, bio is, I mean, listen, it's not just an AI story, but bio is an AI story. I mean, like, for example, if we can like, if we can like recreate like a cell, you know, in a computer, that should unlock so much speed, I would think, to drug development and things like that. I mean, I guess other stuff we're doing, just like, just like competent people at execution. Like, so, I mean, Quince, we were the first big investors in. That's good. That's like, did you have you bought stuff from there?
29:11Yeah, my wife has her house full of Quince. 100 % my wife is obsessed with it. She's like, look, Joe, I'm making you money. I'm like, yes, darling. Yeah, exactly. You know, she's joking. And it's like, no, it's like, well, I don't know what this public there, but it's like more than doubling again this year and the billions of revenue. And it's just such a great executioner. No AI story there, is there? I mean, internally, of course, you're using it to execute well. But really, it's just a good business with good people. It's just like really good. Listen, the real story there, by the way, is that I was the first big investor in Wish.
29:38And I led the seat in the A. And then it went all the way up and all the way down. And there's lots of reasons why it did. Basically, China subsidized the Shein and the Temu competitors, basically. And there's like weird postal changes. And then like the CEO, like probably didn't hire enough people around him to replace himself. So when he had to kind of a breakdown, like the whole thing kind of crashed. So that was tough. But we learned a lot of lessons about how this stuff worked. And so actually my partner Drew with Sid came up with the idea for Quinns after that. It was like a more really high-end luxury type thing with a similar framework.
30:07So if anything, that was like my redemption story after having like personally made and lost hundreds of millions of dollars on that damn thing. That's right. It seems pretty good on Quinns now. It's like, yeah, it's good. And he's doing well. Yeah. And what about energy? It seems like that would be natural. You're in Texas. You know energy now. There's all this cool energy stuff going on. And we kind of need energy for AI. We need it for other reasons too. I love it. It's actually really funny, Jack, because it's like all I go and they'll have me speak to these 200 guys and there's all this really complicated tech stuff to explain that we're doing and how it works and how hard it is.
30:36And they'll just like with a slow draw, just feel like, but they'll have like$5 billion of energy assets and they'll just realize that your stuff's really complicated. But I got a lot of energy. It looks like we're going to make tens of billions of dollars on this. Yeah, it seems like a better business. It's like, oh, man. That's like, actually, maybe the Texas guys are smarter than me. No, when we talk about investing in AI. Different ways to do it, yeah. We talk about six levels, right? So we do energy as the base. We call it zero. Then chips. And then data centers. And then the models. And then software infrastructure.
31:06And then apps and services, right? And so there's like zero through five, six levels. And we're obviously mostly level four and five. I have a few bets at level three with Elon's XAI, with Anthropic, and et cetera. unfortunately all my friends were involved I was a non-profit I stupidly didn't get into it early on but I should have done that and then like the data center stuff I don't really do and then chips we're doing a little bit because it's pretty interesting now I think Nvidia, AMD and Intel are like 99 % of the value right now and that 1 % is probably going to change to like 15 or 20 % from new things would be my guess because there's so many new architectures and so we're doing a little bit there and then we've done a few things around energy I think around like nuclear there's stuff with uranium that's interesting that we're definitely working on i think general matter we're invested in which i think is doing really important stuff like there's just massive works that'll be a mega it's like the monkeys by the way it's like it's like a it's like a controversial supply chain you can get monkeys you can get like you can get uranium feedstock you know so i think these are good things to be doing you know if you do it with the top people i think scott's doing great general matter yeah you know so i mean it's just yeah so we definitely will try to touch the things that aren't there in energy i would say like at hbc it's not really our job to do like the natural gas turbines and stuff.
32:14I think that's a great thing to do. Looking around like the venture market now, you've obviously been doing this for a long time and we're in like a kind of chaotic moment. It's really fun. It's chaotic. It's a fun moment. Well, it seems like this is what, you know, if you can't enjoy it now, like when can you enjoy it? If you're not going to be enjoying it now, you should retire because this is like the best time of whatever we've done. Or to what I imagined 2022 or something was like. It was actually pretty painful like four years ago because it was like, it was like not clear to me yet, like how you could do AI or how AI was going to work.
32:41Unfortunately, it wasn't as smart as some people about how it was going to work. And then you couldn't really start a new SaaS company because I was trying to convince everyone, if you start a SaaS company now, you're competing against SaaS companies now, which is much harder than competing against things when we first started them. So there was a couple of years there where I was like, oh, this is like - Yeah, it was like most of the good stuff was picked over. And I started Saronic then because I spent a lot of time on it because I had a lot of extra time back then because there wasn't as much else to do.
33:02And that worked out. The defense was the right thing, I think, to do. But yeah, but now it's like there's so much. We're like two-thirds of just AI productivity type stuff. Yeah. What do you think is either the sort of structure of firm or individual that is best equipped to succeed right now? You need a lot of young people on your team who are friends with the other young people who are the best programmers and who are in the networks from talent. I just think you do. It's going so young now. I mean, you even look at these accelerator programs. They're getting extremely young. I mean, these kids who are 18 but are AI native and have been programming for a long time, I actually hired Scott Wu as an 18-year-old 10 years ago.
33:41Like, he'd won the gold medal three years ago at IOI and, you know, top in the world the previous year. And, like, this guy, Vlad, on my team helped me, like, hire him. And actually, Alex Wayne came to that same class and all these guys at Adapar. And it was seen as, like, a really weird thing to do back then, but it was really productive. They were really – at that level, they were still really, really good back then. Now it's just, like, 10 years later, it's obvious because, like, a lot of these people are just so good even when they're younger. I know. Yeah. I mean, there's some counter examples.
34:03I had Brett Taylor on the show, and he's an example of somebody like, you can be in your 40s and fully readjust. As a 43-year-old, I'm not totally washed up. But it's rare. And I think, by the way, for the subset who do that, I think it's like a massive superpower because you have all these networks and talent and capital. I think investing right now, even like 10 years older than me, it actually is really hard as a venture capitalist to be in the game. 10 years older than you, you're saying. There's people in their 50s. there are some who are doing it I think it's just really hard to be in the game and frankly it takes a lot of humility because you have to convince all these 22, 23 year olds to hang out with you which is hard I think some of them are used to that in Miami but this is a different version we'll cut that
34:50one of my favorite CEOs last night at an event for a friend I think he's 22 I think he's the one who's tripling revenue this quarter and he's just, he's an AI CS genius. And like, that's, that's, you need to be working. By the way, there's a big advantage that these kids, adults, whatever you, that you have if you're that age, because you never saw the old way of doing it. I know. And so you just have this fresh mind where you're not unwinding anything. And to some of their credit, like to his credit, he wants to learn from me where I think the old way is still relevant, which I appreciate as the old man now.
35:21But so I think there are some of them who's like, okay, we're going to do all these things, all the new ways. But then you can kind of step in and say, well, here's a couple of lessons. And so I do think you still want to mold it. But you do need to rethink from first principles, almost everything right now. And by the way, every few months, because it's changing every few months as possible, which is a weird time. I'm fidgeting around on this podcast because I tweaked my back out. So you need to do peptides. Yeah, peptides. What do you think about all those peptides? I mean, they're everywhere right now.
35:47Do you think this is going to be a huge – we're going to learn that it was all a huge problem? Or do you think this is next coming of the great wave of medicine? So I first had some peptides because I tore up my knee, helloskeying. and then you know so i'm like i got to heal and and not only did it like make me heal faster like fix my back problem it's like oh this is interesting i should study these things and one of our other friends actually you know as well matt mizeo uh he uh had gotten pretty overweight bad blood markers not in shape at all working too hard making too much money so he like took some time off like started taking like a bunch of peptide stacks exploring it and like all of a sudden like seven months later he's like lost over 60 pounds his blood markers are perfect the girls in the office for asking who he was.
36:28He's married girls. And he's in great shape. He's crushing it. And so he's actually our new CEO of a peptides company we're doing that he's founding with us. And it's called NoHo Labs. And it's growing like crazy. This is one of the... I mean, listen, GLP-1s is one of the biggest markets in the world. One of my bioinfrastructure companies I built makes billions of dollars producing GLP-1s. So I'm watching peptides from that side. And now it turns out a bunch of these other peptides are also, I think, going to be market worth hundreds of billions of dollars and we're going after it. It's one of the fastest growing consumers I've ever been part of.
37:01You can go online. We're buying our own compounding pharmacy because we want to have everything done here, everything legit, everything super careful. Listen, RFK himself, he's rumored to be on these. I'll say I won't give him any inside information. He runs HHS. On a bunch of these peptides, you're saying? He's rumored to be on a bunch of them himself. A lot of smart old people. A lot of my billionaire friends are all on these things. It's a legit thing. Was there some unlock that just made us discover, made people discover like a bunch of these things and now we're just like you know there's there's this just like proliferation of new ideas happening at once or what what happened here you know i think the law have been around for a little while and people just started like sharing more stories and i think maybe the fact that people are willing to do the glp ones and they work so well because that is a peptide and that's like the cultural phenomenon kind of opened people's mind up to the others and now the hhs the unlock is that they are taking some of them off the schedule to like make it like more legal to sell them and stuff.
37:54And so I think it's more of like a policy has been holding it back as well. I mean, listen, we have an NIH in this country, which is National Institute for Health. And like, if you're on different political side, you can yell at me for what this administration is doing. I don't agree with all of it. There's like different things. But like the one thing the NIH should be doing is there's something like peptides, which no one's allowed to patent because the IPR already exists. They should be studying them more. If there's tens of thousands, a hundred thousands of Americans using something, why the hell do we not have the NIH studying?
38:19For me, that's why government exists is to do the tragedy of the common type things. So I, and I think they're, and the secretary agrees with me. So I think they're finally going to start actually doing a lot more studies too and approving, which is great because then we can start approving these and make them safe. And listen, it seems obvious to me that they're super helpful. Yeah. You lived here for a long time. Obviously you still spend a lot of time here. By here you mean Woodside. That's right. We still - You're just like the broad here. We still have a house somewhere near here, but you know.
38:42Yeah. But you know, now as you spend most time in Texas, I'm curious - We're based with our six kids in Austin. Six kids in Austin. My brother, Max, lives in Austin. I feel like there's probably some changes to your mindset, I would imagine, by being out of California. I'm just curious if it, like, does it help you think more? Do you feel more in touch with the world outside of tech? Does it change anything? Is it just a place to live? Is there anything about it other than it's just a place to live? It's definitely a different culture. You definitely see. I mean, I'm talking. It's partially because of my policy work as well.
39:16I talk to a lot of people from a lot of red states and purple states, like in different parts of the country. And you see the skepticism of tech. You see the things they're afraid of. And you kind of see more clearly to them. It's just such an alien thing and how certain things come across like much more nitrically than I would see it coming from here. And kind of knowing the insiders realizing what's going on is not as scary as they think. And so it's definitely given me more perspective on, I guess, like you said, we really probably should be doing a better job marketing some of these things for our country and coming across in the right way and respectfully to people.
39:48Listen, it's also a more sane place. I think there's like a really healthy middle class in Texas. I think I have people who work for me there who can live 10 minutes away, even though you only pay them$100 ,000 a year. Whereas if here in Woodside, if you pay someone$100 ,000 a year, they're living an hour away. And I think so. I think it's just a healthier, better place for society the way it works. I mean, we also, I think, have more aggressive and challenging political swings happening here in general. And, you know, you've obviously been, you know, sort of focused on politics for a long time, like back since Stanford Review.
40:17I'm just trying to bring common sense, man. That's my point of view. We actually had someone intern with us who was editor at Stanford Review recently. I love it. All cap before Benchmark. I love it. And I'm like, you know, it's like really good. Anyways, but so like I'm like familiar with like the school of thought and I think it's great. And, you know, I'm just curious, like, as you've watched us go over the last few years through the sort of like, you know, swings of politics and political correctness and all of it. Where are we now? Like, do you think that like, do you think people can more or less say what they want to say now?
40:48Do you think there are still like the Overton windows, not where it should be? There's like, there's still a lot of things that I think like polite society like won't talk about or won't want to understand. You know, there's a lot of reasons for why things are broken. And there's a lot of stuff in California that's very corrupt that I think people here are just starting to appreciate. Like they don't realize the billion dollars for San Francisco to NGOs is not to help the homeless. It's to help a very powerful political class of people who control things. You don't realize that the government worker unions here just really run the state and really just light insane amounts of money on fire.
41:21The budget's got up 75 % here in six years. 75 % in six years. And it's like things are getting not better. What have we gotten? you get much better paid civil servants and you get a few million of them with much better pensions and which is great except for the fact you can't afford that and you and you're breaking so many other things and and so it's you know and in texas you'll have things like in texas we had something where the cities were which cities are always a little bit blue and they weren't permitting things because the people are in mb so we said listen if a city won't get back to a permit in 45 days you go around it to the state and the state will approve it really quickly and we passed this law in austin building exploded the last three years the prices are down 20 in in Austin, not because people are leaving, but because there's just so much more stuff we brought online.
42:00And here, and by the way, of course, Sironics building there, all these companies are building there. The things that we're building there really fast, you still have like five to 10 years later be in permit hell if you're trying to do in California. So we have to fix CEQA in California. I don't think, the fact that people still don't know what CEQA is very much, I'm not sure things have shifted that much. Like this California Environmental Quality Act, it's like there's just crazy things in there where you're like talking to like 14 Indian tribes and you're like in years and years and years of lawsuits to pay off environmental lawyers.
42:27I mean, the whole thing's just broken still. So, and by the way, there are candidates here, even on the left. Like I say the San Jose mayor on the left, I don't agree with him on everything, but he like gets it. He gets it. These interests are broken. So I think you're just having some people come around. Will the people here support the moderates on the left to get it? Because I don't know. Yeah. I mean, sometimes I hope that we're on like a better path, but it's not like it's, it's not getting there as quick. We need the leaders. Things take a while. We need the leaders to actually win and we need people to wake up and actually fight for it.
42:54And too many people here are too scared to fight for what makes sense, even in a moderate way, which is, that's why it's still broken. So, but we need more, more courage, man. More courage. All right. Well, this was super fun, Joe. Thanks for doing this with me. I really appreciate it. Thanks so much, Jack.
From the publisher
Joe Lonsdale is the Founder and Managing Partner at 8VC, an early-stage venture capital firm managing over $6 billion in capital. In 2003, he founded Palantir (NASDAQ:PLTR), a global software company known for its work supporting US and its allies’ defense and intelligence. Since then, he has founded over a dozen prominent companies, including Addepar, a wealth management platform helping investors manage over $7 trillion, and OpenGov, the leading cloud software provider for local governments which recently sold for $1.8 billion.
Joe was an early investor in Anduril, Oculus (acq. FB), Guardant Health (NASDAQ:GH), Oscar (NYSE:OSCR), Illumio, Wish (NASDAQ:WISH), JoyTunes, Blend (NYSE:BLND), Flexport, Joby Aviation (NYSE:JOBY), Orca Bio, Qualia, Synthego, RelateIQ (acq. CRM), Yugabyte, among many others.
We discussed what it takes to keep building after success, why AI is accelerating entire industries, and how it could reshape productivity, healthcare, defense, and the economy. Joe also shared his views on investing in hard problems, rebuilding trust in technology, and where America needs to adapt to win in the AI era.
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Timestamps:
(0:00) Intro
(0:32) Why Joe keeps building
(3:53) AI being contrarian and right
(5:39) What Palantir got right
(6:53) Pulling forward innovation
(9:32) AI vs social media
(12:23) Making AI work for America
(18:03) Department of War debate
(21:16) Betting on defense
(26:51) Robotics, bio, and energy
(32:16) Investing in the AI era
(35:38) Peptides opportunity
(38:35) Texas vs California
(40:12) Political correctness
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