In short
Discussion of GLP-1 weight-loss drugs (e.g., semaglutide/Zepbound-type “Ozempic” and tirzepatide/“Mounjaro”)—benefits for obesity and metabolic disease versus risks, especially when stopping, microdosing, or using unregulated/counterfeit sources. Also covers “food noise” (cravings/chatter) and non-drug strategies (protein, fiber, strength training, stress management).
Guest background
Dr Jack Mosley is a weight-loss expert and author of Food Noise. He discusses obesity trends, metabolic health, and behavior/emotion links to eating.
Key claims
GLP-1s can reduce obesity-related risks and cravings, but weight regain is common: about 80% regain weight; up to 40% of lost weight can be lean muscle. Rapid weight loss can cause muscle loss, nutrient deficiencies, and “Zepic face” (including hair loss). Risks include GI side effects plus pancreatitis, bowel obstruction, and gallstones; risks rise with unregulated sources. Microdosing for cosmetic/longevity lacks long-term evidence.
Notable examples
“Zepic face” hair loss noticed by hairdressers; counterfeit “triple agonist” dosing errors (e.g., insulin instead of GLP-1) leading to hospitalizations; observational studies suggesting lower opioid overdose risk and reduced heavy drinking days in people with obesity.
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VOUnderstanding Ozempic and GLP-1 Medications
0:45 to 2:46
Discussion on the effectiveness and concerns of GLP-1 medications like Ozempic.
“The risks are really big, they're really amplified when you're getting it off some unregulated source.”
The Rise of Obesity and Its Consequences
2:46 to 4:00
Exploration of the obesity epidemic and its related health issues.
“So, I would just like to say I'm not necessarily for or against.”
Impact of Snacking on Health
4:00 to 5:27
Examining how snacking habits contribute to weight gain and obesity.
“And this has led to this tidal wave of obesity-related diseases, everything from heart disease, sleep apnea, high blood pressure, type 2 diabetes, and even things like dementia are significantly increased.”
The String Test for Metabolic Health
5:27 to 7:17
Introduction to the 'string test' for assessing metabolic health.
“of processed junk foods like crisps, chocolate, sweets, all of these sort of things.”
Muscle Loss and Weight Loss Medications
7:17 to 10:41
Discussion on how GLP-1 medications can lead to muscle loss during weight loss.
“And if you can't, it may be a sign that you're not quite as metabolic healthy as you might like to be.”
Benefits of Ozempic for Obesity Management
10:41 to 13:58
Highlighting the benefits of Ozempic for individuals with obesity and related conditions.
“weight loss medications, you may have lost a significant amount of fat, but also muscle.”
Exploring the Opioid Crisis Insights
15:01 to 16:49
Discussion on the impact of GLP-1 medications on addiction and the opioid crisis.
“I mean, even here, so this is your book, Food Noise, which is, I have to say, like one of the best titles I've seen of a book.”
The Dual Impact of GLP-1s on Health
16:49 to 20:34
Exploring the benefits and risks of GLP-1 medications in obesity and mental health.
“I think the thing that when we first heard about GLP-1s, it was so connected to type 2 diabetes and weight loss.”
Concerns Over Celebrity Weight Loss Trends
20:34 to 22:20
Discussion on the societal impact of GLP-1 medications and celebrity endorsements.
“Yes, I think it does have the potential to do that on a kind of quite a major way.”
Evaluating the Risks of GLP-1 Use
22:20 to 25:16
Insights into the potential side effects and long-term risks associated with GLP-1 medications.
“So you've got those immediate side effects that are quite common really actually.”
Show all 30 chapters
Black Market Concerns and Health Risks
25:16 to 27:39
Exploring the dangers of obtaining GLP-1 medications from unregulated sources.
“You wouldn't go to a GP and get them unless you kind of met the category of basically what you would have to meet being a certain weight to go on these drugs.”
Microdosing GLP-1s: What You Need to Know
27:39 to 28:01
Discussion on the implications of microdosing GLP-1 medications and their effects.
Microdosing: Potential Benefits and Risks
28:01 to 28:56
Learn about the reasons people microdose and the potential long-term effects.
“So what about people that are microdosing with it?”
Perceptions of GLP-1 Medications
28:57 to 30:05
Explore the hype surrounding GLP-1 medications and their perceived benefits.
“It would not surprise me if they do improve longevity for certain people, but this is really for those people with those obesity-related diseases who are at massive increased risk of heart disease.”
Nutrient Density and Food Environment
30:06 to 32:46
Understand the importance of nutrient-dense foods in addressing obesity.
“And there was just these like big claims from, you know, doctors are being like it's cured my daughter's PCOS, it's totally changed this part of inflammation.”
Nutrition and Lifestyle Strategies
32:47 to 34:10
Discuss the importance of nutrition and lifestyle in weight management.
“And they've kind of done this in conjunction with the rise of GLP-1s.”
Emotional Connections to Weight Loss
34:11 to 36:16
Examine the emotional aspects of weight loss and the impact of food noise.
“And I think also, it's not just people that are on GLP-1s.”
Understanding Food Noise
36:17 to 37:48
Learn what food noise is and how medications can help mitigate it.
“And kind of understandably, with the stigma we kind of have in society around obesity, which is a real problem, them.”
Role of Lifestyle Interventions in Prescribing
38:34 to 41:41
Discuss the importance of lifestyle interventions alongside weight loss medications.
“Like all of these, making sure that the nutrient density is in check.”
Navigating Food Environments Without Medications
41:42 to 42:01
Explore strategies to manage weight and cravings without relying on medications.
Navigating Food Cravings Without Medications
42:01 to 43:51
Learn strategies for managing food cravings and improving meal planning.
“on and just not being able to have the interruptions of day to day and feel like I can just go through.”
The Importance of Self-Compassion in Weight Management
43:52 to 45:47
Understand how self-compassion can influence eating behaviors and weight loss.
“So first off, naming what you are feeling.”
Challenges of Stopping Weight Loss Medications
45:48 to 48:36
Discover the rapid weight regain challenges faced after stopping weight loss drugs.
“And even think people that are stuck in binge eating cycles to give yourself a bit of a break is really important because you kind of can't undo what's already been done.”
Sustaining Weight Loss After Medication
48:37 to 51:29
Explore dietary strategies to maintain weight loss after ceasing medications.
“So with this new generation, you may have lost 15 % of your body weight, but within around 20 months, typically on the studies, you have regained it all.”
Nutrient-Dense Foods for Effective Weight Loss
51:30 to 56:00
Learn about nutrient-dense foods and their role in effective weight management.
“And this was compared to a lower fat diet, which had kind of starchy carbs.”
Nutrient Density in Diets
56:00 to 56:40
Learn the importance of nutrient density over calorie restriction in diets.
“And they contain all of these protein, but healthy fats as well.”
The Role of Exercise in Weight Loss
56:40 to 58:00
Understand how exercise complements diet for effective weight loss.
“So once again, that's why it's so important to kind of make every bite count in these circumstances.”
Brain Benefits of Physical Activity
58:00 to 1:00:00
Discover how exercise positively impacts brain health and cognitive function.
“and ingrain some of those habits for the long term.”
Incorporating Movement into Daily Life
1:00:00 to 1:02:50
Find practical ways to integrate more movement into your everyday routine.
“So things, and even thinking about simple things like, instead of getting the train, the tube, driving to work, thinking about cycling to work.”
The Concept of Live Well Be Well
1:02:50 to 1:06:00
Explore the broader definition of health beyond just weight and diet.
“So pairing, you're putting the kettle on and pairing it with an activity.”
Transcript
Automatic transcript. May contain errors.0:00What are the benefits of taking a Zempick or GRP1? They probably will save many lives through reducing obesity. I like to think of them as noise-canceling headphones. They reduce your food noise, but there are definite issues. Dr. Jack Mosley, weight loss expert and author of Food Noise. Here's what the diet industry doesn't want you to know. How quickly are people regaining their weight? Quite rapidly, actually. 80 % of people will regain their weight. Research shows up to 40 % of that weight loss can come from lean muscle, not just fat. This is one of my concerns with the GLP-1. What about a Zempic face?
0:36A Zempic face is caused when you, there's quite a few people who do get hair loss. Some hairdressers say that they can spot the people on the GLP-1 weight loss medications because of that. The risks are really big, they're really amplified when you're getting it off some unregulated source. Now there's something called a triple agonist and what that means is it works on three receptors. So that is as effective as bariatric surgery. So should alarm bars be going off then if people are microdosing these purely for cosmetic reasons? I would say so. Does it outweigh the benefits or does the benefits outweigh the risks?
1:14For the last two years I have kept a secret from you and it's this. It's my new book, Healthy Shouldn't Be This Hard. and I think it is a problem that we are all feeling. And I was feeling it so much that I wrote a book on it. Now, if you've been a guest of this podcast for a while, you know that I am all about kindness, self-compassion. But when I dug into the research of this, my mind exploded. The connection between the mind and body is so integral, but we completely miss out on all the conversations on health, on how we speak to ourselves. And that is such a driving factor on how our food responds to what we eat to, the choices that we make.
1:53And we are so overwhelmed right now in the$8.5 trillion industry that is the wellness industry, which is predicted to be by 2027. So if you need a helping hand, if you want a new way to live and be well, and buy my new book, Healthy Shouldn't Be This Hard, out on May the 28th, but you can pre-order it now. I'll pop the link below in the show notes. And I would love if you could support me on this. And I honestly think it will support you too. This is a very timely conversation we're about to have. So we're going to discuss everything GRP on medications. Now, for some people that don't know what that is, people might recognize it through the American brand name, such as the Zenpik.
2:34And they have become hugely popular, so popular that you've actually written a book on it. So as a GP registrar, I just want to ask you straight up, where do you stand on these drugs? Are you pro or are you against? Start with the heavy hitters. So, I would just like to say I'm not necessarily for or against. I would say overall, for the general, for the overall population, they probably will save many lives through obesity, through reducing obesity and obesity-related diseases. But there are definite issues with these medications, and they really do need to be paired with changes to your lifestyle.
3:12Such a scientific answer there. Never give one or the other, always the nuance for you. Well, we're going to go into why you're for and against. So it's really rare for a drug to have such a large impact so quickly in the rise of medicine, and also not just for one chronic disease, for so many. So before we kind of talk about the for and the against and the pros and the cons, how do we get to this crisis point that we're all now looking at this kind of miracle drug as a cure? Well, we've seen this dramatic rise in obesity over the last 60 years, really. And there are many factors for this, but we've seen an increase in the UK from around 1 to 2 % back in the 1960s to around 30 % today in the UK and over 40 % in the US.
4:02And this has led to this tidal wave of obesity-related diseases, everything from heart disease, sleep apnea, high blood pressure, type 2 diabetes, and even things like dementia are significantly increased. So there are obviously a really big range of factors that are responsible for this, but some of the key ones are this rise in the Western diet, so that's the processed junk food. But there's other kind of smaller things like snacking has rapidly increased over the last few decades, that's become the norm. we even have bigger plate size and we are definitely more sedentary than before so modern society does not help with any of this i find that really interesting about the snacking because i think you know my mum used to always say little and often but actually that kind of skews us to potentially eating more and i know there's a lot of really interesting research now coming out that people that do snack more obviously have a higher weight gain and are more likely to be obese, which is really interesting.
5:06I don't know if you've seen that when you were researching your book. Yes, completely. So the, yeah, the stats say like 90, 95 % of our snack at least once a day. And it's something like 70 % have at least a couple of snacks a day. Now the, you can have healthy snacks, things like nuts and fruit, that sort of thing. But realistically, the vast majority of the snacks that we do eat are many of these kind of processed junk foods like crisps, chocolate, sweets, all of these sort of things. So they're often packed with sugar and they are packed with refined carbs, salt, flavourings, all of these sort of things.
5:44And these are, they are burnt off really quickly, but they also keep us wanting more and more. They're dopamine hacks, aren't they? Yes, exactly. So the, many of these foods are developed by food scientists to literally hack your brain. And like you say, dopamine, that is the chemical that it's involved in wanting. So it teaches your brain that was a nice tasty treat and keeps you coming back for more. Yeah, we actually had, who's given you a quote in your book, but Chris Van Taliken, who wrote Process People. He came on this podcast when he released his book. And I mean, I mean, our listeners absolutely loved that episode.
6:28We dissected lots of different foods live so people could start to understand. And it shocked me just, you know, how much that we don't really foresee in our day to day that is processed because it's such a confusing landscape. Now, you talk about something really interesting because I think there's a bit of a debate about BMI. You know, does it take into account muscle health or not? But you talk about the string test. Can you tell us about that? So the string test is really simple and it's a good way to assess your overall metabolic health. Like you said, the issues with BMI is that it doesn't account for muscle mass.
7:06So you might have a rugby player who's carrying a lot of muscle but have a high BMI and they may actually be relatively healthy. The other thing it doesn't account for is that distribution of fat. So there are lots of different types of fat. The two important ones are this subcutaneous fat and this is a fat around your hips your arms it's not dangerous but the fact that we are concerned about that affects your metabolic health is a visceral fat and that's typically around your belly so what the string test involves is it's essentially your your height to waist ratio really and it's quite a crude test but all you have to do is you get a piece of string you extend it to your full height, then you fold it in half and see if you can fit it around your abdomen.
7:55And if you can't, it may be a sign that you're not quite as metabolic healthy as you might like to be. Quite interesting. I wonder how many people now are going to be going to pick up string and standing up and measuring themselves? I think I should have done that. I mean, you're definitely going to pass. You're very lean and tall. But I think one big concern around around this is that it can feel like a quick answer. And I think for some, it's really needed. And it's, you know, very much looked at when we had the gastric band, you know, there are certain measures that some people really do need help with.
8:34But I guess when we look at the landscape of this, it's also can be quite dangerous. Now, the thing that I think is really important to talk about here when it first comes to GLP-1s is muscle. So people can lose 15 % of their body weight, but research shows up to 40 % of that weight loss can come from lean muscle, not just fat. So I think that's where people maybe aren't quite understanding how quickly this weight is dropping and where it's dropping. You just mentioned there are two really interesting types of fat, but then also we have muscle on top. So what does that mean for people that are losing weight quickly and up to 40 % of that is muscle?
9:13This is, yeah, this is one of my concerns with the GLP-1 weight loss medications that, like you say, up to 40, so it's between kind of 25 and up to 40 % of that weight you lose is lean body mass. And the main component of that is muscle. And what, and the reasons for this are primarily when you go through any rapid weight loss, you can lose muscle, which is why it is so important to do certain things to prevent that. And that kind of includes increasing your protein intake whilst you're taking these weight loss medications and doing some basic strength training. So why is muscle so important? Well, it's actually very strongly associated with longevity.
9:56When you look at some of the studies, they find that both grip strength and leg strength is actually very strongly correlated with a long lifespan. The other really important reason and part of why this could be the case is things like your future frailty. if you have enough muscle to do simple things that we take for granted right now getting off the chair and reducing your risk of future falls future hip fractures all these sorts of things it's also a really important sink for your glucose so it soaks up a lot of the sugar in your blood and i think finally it's very important for your metabolism it burns much more calories than fat.
10:39So this could also be one of the reasons why when you've lost, when you're taking these weight loss medications, you may have lost a significant amount of fat, but also muscle. But when you stop these medications, you will be, what we see in the studies is you do rapidly regain that weight. And again, one of my concerns here is that, and we do need more studies looking into this, that fat is more easy to regain than muscle. Yeah, I mean, we know how hard it is to especially as you get older, we know how hard it is to gain muscle. We talk about this a lot with perimenopausal and menopausal women, also how important it is to make sure they're maintaining their muscle during especially this phase, because that's when estrogen becomes, you know, drastically reduced and there are much higher risks of things like, you know, osteoporosis and things like that later on.
11:30So that's really important for them. But then also with the rise of a Zempick, it puts us in this really interesting dynamic. so let's talk about the risks does it outweigh the benefits or does the benefits out raise the risks so what are the let's start with the positives what are the benefits of taking a zempic or grp1 so for people who are living with obesity and potentially poor metabolic health and what i mean by that is they may have high blood pressure high cholesterol uh they risk up ischemic heart disease, or strokes, or sleep apnoea, for some of these people it can have a massive benefit, and especially people who have tried many other types of diets.
12:16Like I say, the food environment we do live in, there are temptations everywhere, and I understand it's very hard for certain people to lose weight. So just looking at some of the studies, with heart disease, it reduced the risk of heart disease by around a quarter, as with chronic kidney disease. With sleep apnea, this is a condition where people are carrying often too much weight around their tongue and their neck, and they actually stop breathing multiple times throughout the night. And this is much more common than we think. Well, it reduces the number of these apneic episodes where they stop breathing by about half, massively reduces the risk of type 2 diabetes, because we know that's so strongly associated with weight, and again, weight around the middle.
13:01What is very interesting as well is we're looking at its role in addiction. So part of the way these weight loss medications work, they reduce your physical hunger, but they also reduce some of your food noise. So that's your cravings. I love that word. Yeah. And I think it's something that a lot of people can relate to, this food noise. So it reduces those cravings and when you see that chocolate bar you can potentially resist more than you could before with these weight loss medications. So this appears to impact your reward centers and that's why they're also looking at how it could affect things like alcohol consumption.
13:45And this is with people living with obesity and also alcohol addiction, alcohol use disorders. and they did find that it did significantly reduce the number of heavy drinking days and the overall alcohol consumption but only in people who also not only had a alcohol problem but also were living with obesity most varno's products are built for someone with four hours sleep to spare and a cold plunge in their garden dion is built for the rest of us it's a day-to-night system formulated by medical doctors designed around your body's natural rhythms during the day grounded a go-to convenient sachet supports calm and focus without making you drowsy.
14:24In a real life UK study, 90 % of people felt a benefit within 15 minutes. And I take mine after interviews to really help calm my nervous system. At night, rested, a nightly capsule with botanicals, vitamins, and magnesium helps you actually sleep. In their study, volunteers gained up to one hour of additional sleep on average within the first week. Over nine in 10 reported more restful sleep. Grounded is launching very soon and you can shop both at diome.co. That's D-I-O-M-E dot co. Use code Sarah20 for 20 % off, whether you're buying once or subscribing. Wow. I mean, even here, so this is your book, Food Noise, which is, I have to say, like one of the best titles I've seen of a book.
15:08The opioid crisis is a really big thing in America right now. And I've watched things like Dope Sick and all of the programs. It's amazing. And you don't quite realize just like how strong the opioid crisis is but you said here study examining the medical records of over 1 million people in the usa found that those that were taking grp1 medications had a 40 reduced change of overdosing on opioids and then with those of an alcohol addiction they were 50 less likely to get drunk that's quite amazing isn't it it is absolutely fascinating and that that is an observational study so we can't say for certain this is going But it's a really interesting study for sure.
15:51And I think it does highlight the fact that this could have some role in our reward centers and in managing addiction. And even with some of these other studies, they've seen people taking these weight loss medications. They're smoking less. as well. And like you say, the opioid crisis is still a massive problem today in the UK as well, but more so in the US. There's massive access to fentanyl and prescription drugs. And that's kind of where it all originates really, to be honest. It's interesting because it's kind of like another prescription drug going against another prescription drug when you look at it at the horizon like that.
16:33And there are all these interesting kind of interplays there, because then you've also got big pharma against big food. So big pharma trying to solve a problem created by big food at the end of the day. Exactly. So it's kind of this arms race. I think the thing that when we first heard about GLP-1s, it was so connected to type 2 diabetes and weight loss. I think that's like where it started to spark. But then you were hearing, oh, it helps with longevity. I mean, even in here, we've got bipolar, schizophrenia, depression. We've got mood disorders. you know, as well as obesity being one of the biggest killers of today, mental health issues and problems of people suffering with their mental health illnesses is also rising so rapidly.
17:17So we've got like these two sectors that this drug seems to be able to treat quite well and quite quickly. Do you feel that because there's now been such like a huge wave of this discussion, you know, there's headlines everywhere, we're seeing celebrities from people like Kelly Osborne to Oprah to Rebel Wilson all talking about their experiences on this and we see we see the outcome right we see them looking thin and full of life and like they've got their glow back is there a worry that this is too good to be true I think this is where some of the problems I've mentioned about there are these some of these incredible effects of these medications and there is this crisis of obesity that we are trying to solve and but this is where we do come to some of the yeah some of the issues of these medications so you do have a lot of a lot of celebrities who are using these medications I think it was all the rage in in Hollywood before it kind of hit the mainstream market and I do really have concerns that although these medications are definitely helpful for certain people living with obesity not for everyone because there are some risks and they're definitely not for everyone so I'm not saying everyone with obesity should take it but people who have a healthy BMI or even of kind of a lower weight I think this is when that risk to reward benefit really starts to mount up in the opposite direction and actually for some people those risks really start to mount and I think this is from several reasons.
18:56For some people, like we've mentioned, some of these other issues, which I could go into a bit later, but things like muscle mass, nutrient deficiencies start to mount up. But also people who are at maybe a risk of an eating disorder, then this could definitely exacerbate that. And we know that is the case. Well, it's interesting. So do you remember that I don't know if it's officially been put in the DSM v5, which is the manual where different type of mental health disorders are put into and characterised. Orthorexia. Yeah. It was a very big term about ten years ago when the clean eating came out.
19:33And I'm not sure if it was ever officially coined, but it was basically the fear of not eating anything clean. Um, and I feel like this, again, could start another new wave of this type of thing. And I was thinking about this today before you came on, the, you know, a cultural message. I'm from the modeling industry, for anyone that has no idea of my previous background, if you haven't listened to the show. And I was very much in that wave of the orthorexia movement. Very much the thin is beautiful and the ideal body weight and the pressure as a woman to be thin and, you know, you're skinny and strong or whatever instead of, you know, now the message feels like it's about more about muscle and feeling strong in yourself.
20:13It's more about your mental health, which I think is a really amazing transition. But the cultural message a few years ago was very strong in body positivity. And I've seen this rise of GRP1s come up and a lot of celebrities drop weight very quickly. Do you think this is also revealing something about how we're looking at society with weight and health? Yes, I think it does have the potential to do that on a kind of quite a major way. Like you said, we have started to move into kind of some better directions with it's not just about weight and it's more about overall health. It's about all of these lifestyle interventions from, you know, eating well to exercise.
20:59This can really improve your mood. And, yeah, it's not about just the numbers on the scale, but, you know, also things like muscle and overall well-being is much more important. And that's what I, yeah, that's what I'm really passionate about. So you're right. There may be, and we are potentially seeing this move towards, you know, going back to skinny is great again. And I don't think that is necessarily the best message. And you mentioned, yeah, you've obviously been in the modelling industry where there are undoubtedly these incredible pressures to be skinny. So it would not surprise me if there is quite a lot of GLP-1, a Zempick and Manjaro use within the modelling industry already.
21:43and that's again a bit of a concern. Well, I want to get onto that actually. I want to get onto the microdosing in a second, because I think this is a huge way. But before we get onto the microdosing, we've got to talk about the risks. Because as we just touted, a lot of people are putting longevity onto these drugs and I'd love to know what the research is there. Do we really know if they have an impact long term or do we know that it's quite short term? But what are the risks first associated with this? Because I think this is maybe what we aren't hearing as much. So some of the immediate, so starting off with the side effects.
22:15So some of the side effects appear because of the way it slows down your overall digestive tract. So you've got those immediate side effects that are quite common really actually. So nausea, some people actually vomiting, especially if you continue to eat what you ate before, things like constipation or diarrhea. Some of these are fairly, fairly common. And then you've got some of these other more dangerous side effects. So you've got things like pancreatitis, so that's inflammation of the pancreas. Bowel obstruction, so that's a blockage of the bowel because it slows the gut really down. It's very, yeah, exactly, a very serious problem.
22:55And things like gallstones as well. Some of these things like pancreatitis, they do get a lot of the headlines. Overall, the risks are still fairly low. But it's something to be aware of. Well, I had a call from somebody that I used to know that worked in the fashion industry. And he'd been on a Zenpik. I don't know actually, that's wrong. He might not be on a Zenpik, but he'd been on a GRP1. And I can't remember which brand it was, so I don't want to demonize the brand. But he'd been on a GRP1 drug. And fair to say, he said to me, it's changed my life. I went from chronically obese to now having a healthy weight and it has totally changed the way I see life and how I can move and all of these things so it had huge benefits but I say with a but he's like I've lost all my hair from being on this drug and I had no idea that hair loss was a thing again I've had really bad like GI problems but for him the risks versus the benefits, the benefits outweigh the risks, because he actually really, he was somebody who was very much suited to go onto this drug.
24:04And we look at it from vanity reasons, I guess, on the longevity side, or when people are microdosing to lose a little bit before their beach holiday comes up, or maybe they feel pressure from their community that they're in. I know the gay community feels this a lot. I think we forget that also, you know, hair loss is a significant thing from a vanitry metric. And it's not spoken about enough. So when you were interviewing people for this book, did you come across any of these stories? I did. And there are quite a few. Yeah, there's quite a few people who do get hair loss. Hairdressers are even commenting on it.
24:43Some hairdressers say that they can spot the people on the GLP-1 weight loss medications because of that. And part of that is because of this, the fact that you are losing weight more quickly. Some of it may also be lack of nutrients. So we do know there's lots of different nutrients that are really important in your hair. Things like iron, zinc, some of the B vitamins, they're all really important and protein as well. So there is a range of factors there. But yeah, unfortunately, that is a side effect of the medications and just back to what you said about the beach body people get it using it for beach body getting beach body ready or a wedding these ultimately they're not cosmetic medications i don't think they should be used as such these really are for people who are living with obesity and obesity related diseases really what's the risks of people that are going on these more that aren't on the the natural selections i know still here you can get them i don't know but i call it black market.
25:45You wouldn't go to a GP and get them unless you kind of met the category of basically what you would have to meet being a certain weight to go on these drugs. But people are still accessing them, whether it's via the dark web or beautician or I don't know where they're getting them from. But people are still getting them and they're still microdosing. What are the risks associated with those types of people? The risks are really big. They're really amplified. When you're getting it off some unregulated source. For instance, some of, so we kind of just mentioned some of the medications. So there's a Zempic, a Zempic, which is semaglutide, Manjaro, which is tezapatide.
26:25Now there's, there's a third, well, there are other medications coming through, but those, so a Zempic is a single agonist, so it works on one receptor. Then Manjaro is more effective because it works on two receptors. Now there's something called a triple agonist. And what that means it works on three receptors. So that is as effective as, as bariatric surgery, but it's not yet released this medication, but at the same time, people can still access counterfeit versions, which are often coming from kind of labs in China. And, and it's not often the correct version that may there's horror stories of people who have been given three times a recommended dose, things like insulin instead of the medications.
27:14And they've been hospitalized with their blood sugars dropped really, really low. And they, you know, they felt very unwell and it's a life-threatening thing. So I think when you're getting it from a unregulated source, that's when the risks really ramp up. And we're also seeing that happen quite a lot in things like gyms and beauticians actually but it can be it can be anywhere so it's very important that if if you do make the choice to pursue these weight loss medications and it is a very individual choice you really should get them for a regulated source i'm laughing because it actually is a peptide but grp1 is a peptide and there's a lot of conversations on the rise of peptides as well just on how regulated they are and we don't really know what these long-term effects are yet.
28:01So what about people that are microdosing with it? What would you say if anyone's listening to this wanting to microdose or microdosing, what is the thing that they really need to know? So with microdosing, people are doing it for a range of different reasons. You mentioned things like longevity. Some people may be microdosing just at a lower level to keep their appetite just slightly reduced and keep that weight off for longer period of time but one of the things we really don't know is this the long-term effects on people if you're microdosing and you are of a healthy bmi as i mentioned there's no there's no long-term studies on that and that's when potentially the risks do start to increase so so it's not definitely not something i would be recommending as a doctor because we just don't have the studies to know.
28:48I suspect that these medications are linked to longevity, but again, there's not really much evidence on this yet. It would not surprise me if they do improve longevity for certain people, but this is really for those people with those obesity-related diseases who are at massive increased risk of heart disease. Again, one of the reasons people, another reason some people are thinking of microdosing is that role in inflammation, which they do seem to dampen down. But again, that is far more pronounced in people living with obesity. And we know when you're living with obesity, that slowly burning fire that some people can get when they have obesity and poor metabolic health, that can be ramped up.
29:38So we know when you're living with obesity and you reduce your weight, then that is reduced. So I suspect most of the impact is from just losing weight. Have you found that since you wrote this book on food noise, and obviously like, you know, half of this is about the rise of the GRP1 medications like a Zenpec, do you feel that you are now more aware online of seeing people talk about this from a point of the miracle cure? Because when I was researching this podcast, I go down, I listen to lots of other podcasts, I'll read lots of other books, I want to see where the landscape is, like what's, what are people talking about right now?
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30:10And there was just these like big claims from, you know, doctors are being like it's cured my daughter's PCOS, it's totally changed this part of inflammation. And I think, you know, we can look at it as in like, okay, well, actually, I'd much rather not have inflammation or PCOS, so I'm just gonna, I'm just gonna take it. And it can just feel too good to be true. It's really interesting. So you mentioned, yeah, PCOS, so polycystic ovary syndrome. Now, that, that again, is quite strongly, not for everyone, but it can be quite strongly linked to being overweight or living with obesity. So, and we do actually know that things like PCOS, it can improve with weight loss.
30:51So, I don't think as of now there is studies to directly say GLP-1s reduce PCOS, but there is definite reasons to believe that it definitely could improve those things. Because again, with people who are living with obesity, who have PCOS and maybe struggling to get pregnant, sometimes when they lose a bit of weight, they find it much more easy. So there is some evidence to support some of those things. I think seeing it as this fix-all medication, that's where it's not clear. And I'm quite sceptical of some of the miracle cures that people are suggesting. But there are many diseases that are associated with obesity.
31:32So like I say, losing that weight can make a big difference for some people. But there are obviously many other routes to that and it's still so important to have the right nutritional and lifestyle strategies when you're on these medications. Definitely. What I think what's really interesting is that, so in the UK, if you're listening in America, you will have no idea what this means, but there is a famous shop here called Marks and Spencer's that have a food range. They're actually quite known for their adverts around Christmas time. And they've announced this year in 2026 that they have released a nutrient dense range.
32:09So basically, you mentioned very earlier that one of the many reasons that we might be in the state that we are today with our obesity is because of our food environment. We're eating on bigger plates, we have bigger portion sizes, there's less nutrient density in our foods. So it's more ultra processed, which is like two thirds of our shopping baskets. That never seems to blow my mind, that stat. And so what they've done is made the meal smaller, but they made them more nutrient dense. They're packed with more protein, more fiber, more vegetables, to trying to give people a smaller but more kind of nutrient filled meal, which I find really interesting.
32:47And they've kind of done this in conjunction with the rise of GLP-1s. I mean, I think it's quite good for everybody because it means that we're actually eating more foods that are nutrient dense, but it's so interesting how it's even shaping now certain landscapes within our food environment. It really is, isn't it? And it definitely is. It's a step in the right direction, some of these moves, and making these nutrient-dense meals. For instance, like you said, you mentioned protein and fibre. Because your appetite is so restricted, every bite really does count when you're on these medications.
33:20Eating those nutritious foods is more important than ever. For instance, eating enough protein to reduce your muscle loss, because again as we get in that calorie deficit you're you are at increased risk of muscle loss eating enough fiber i think is also really important because it can also mitigate some of those side effects i mentioned and gi exactly so reduce your risk of things like constipation and it's generally good for our gut health and our overall body um and then just making sure you do have all this right range of nutrients as well, because we are eating these foods a lot of the time that are calorie dense, but nutrient poor.
34:02So many people living with obesity may also simultaneously have a kind of micronutrient deficiency. Yeah, that's a big one, right? And I think also, it's not just people that are on GLP-1s. When I was studying nutrition, and we'd also see this with people that were over-consuming processed foods. So they're still gaining the calories, but they were very undernourished. So we had this kind of skew where you're overnourished but undernourished at the same time, which is like a really interesting definition to look at. When you were speaking to people for your book, Food Noise, and you were kind of going, and there's lots of different case studies in there, what was kind of your understanding of speaking to people who were exploring this, whether they needed the drug or not?
34:45Like, what were your interactions? It was a mix of people, actually. So it was really interesting to see those different range of people. So there were some people who had just really struggled with weight a lot of their lives and were significantly overweight. And it was giving them a lot of, yeah, it was giving them some benefits. But there also were certain people who were kind of of a normal BMI. and and this is where there potentially does need to be more regulation on this because they were just able to send a um i can't remember exactly what they did but some people are sending ai photos or yeah or photos in strange positions to make themselves or photos of someone else so it's quite easy to trick the system where i think at the very least there should be a you know video consultation or ideally an in-person consultation because it's kind of like the wild west out there of online pharmacies.
35:43It is, I think. What was their emotional connection to all of this when you spoke to them? Because I think that's such a big thing that weight loss is such an emotional topic. You know, whether it's weight gain, weight loss, I feel like I spent a lot of my life growing up around weight. And, you know, whenever we do a podcast on weight, it does really work. Because I do think it's a pain point for so many people, but it's also so emotional. So like, emotionally, how were these people with you? Like, were they relieved? Did they feel overwhelmed? Like, what was your landscape understanding of that with them?
36:17Well, I completely agree that it is such an emotional issue for many people. And kind of understandably, with the stigma we kind of have in society around obesity, which is a real problem, them. But one of the things they definitely did notice is this reduction in food noise.
36:41Talk to me about that. What is food noise? Because that is the title of the book. I do have to say, you will not know this, when we were looking for the title of my book, yours came up and I was like, I want that title. Yeah, I'm quite happy with the title. I was like, it's genius. Thank you. So food noise is your cravings. It's for some people that incessant chatter about food. Some people wake up thinking about food. They may be planning food whilst they're currently eating. For some people, it may just pop up as a craving during the day, you know, in that afternoon slump or when they're stressed, tired or bored.
37:16And emotions play a massive role in not just how we think about our weight, but also how we think about food. and actually they do drive us to eat these sugary salty snacks as well. So one of the ways these weight loss medications, I like to think of them is they're like noise cancelling headphones. So you put them on, you put them on, you can go about your day, you're less tempted by these sugary snacks. But when you take them off again, that food noise does come rushing back with a vengeance. So for some people, it can create this opportunity to try and build in these sustainable habits and eating patterns and lifestyle changes without that distraction of food noise.
38:01But clearly, when you stop the medications, there is an issue that that food noise comes back. I'm interrupting for one moment to ask one small favour. Please subscribe to the show. This helps it grow more than you know. And I'm so bad at asking this from you. I'm so bad of thinking about this, but you know my goal is 100 ,000 to get to on YouTube, and I really want to bring you more content and bigger episodes, and we can only do that with your help together. So please do hit subscribe. Thank you. Do you think that GPs or physicians or whoever is prescribing this is giving those lifestyle interventions?
38:41Because I think that's been the biggest conversation that I've seen going on right now, GLP-1s, is yes, it's producing rapid weight loss, but it has to be administered with lifestyle interventions such as high protein, such as weight training to keep your muscles intact, which is the one thing that we keep talking about. Like all of these, making sure that the nutrient density is in check. But like, are people doing that? Or are people being told that? Or are people kind of being left on their own devices to figure it out? Again, it is a mix, but on the whole it's a kind of a bit of an afterthought to be honest these lifestyle changes and i think it should be at the forefront of everything you do around these weight loss medications making sure you're eating these nutrient dense foods with plenty of you know protein fiber healthy fats vitamins minerals we know the mediterranean style diet is one of the best studied and is the one of the ultimate health bullets and doing these extra things like basic strength training is, is so important, um, so that you do preserve that muscle loss and even do it, looking at it in a kind of more holistic way.
39:51We kind of mentioned how stress and emotions play such a big role. So addressing some of those things and doing even things like mindfulness and, um, and looking at reasons why you are eating certain things. Um, I think that's all really important whilst you're on these weight loss medications. And I don't think the online pharmacies are necessarily doing a great job at that because their key goal is just to really ship off as much of this product as possible, I think. Well, I don't know if you saw this, and this is no kind of force against GPs, obviously, but the BBC reported that GP practices would receive bonuses prescribing weight loss injections eligible to patients this year and next year of up to£3 ,000.
40:35I think when people hear that they might feel uncomfortable. Like, how do we think about that? It's quite an interesting thing that I read that as well. And I don't know where to begin with that. Because firstly, these weight loss medications, I think they could be very beneficial, as I've talked about. But even at the moment, the way it's rolled out on the NHS is going to be very, very slow. So they are still only actually available for a very, very small number of people on the NHS. And those are typically people who are living with really severe obesity and kind of four or five obesity related diseases.
41:16And it will be a kind of slow rollout over 10 years. I'm not sure how that is going to impact things. And maybe that does give the wrong motivation. Many GPs will be happy to prescribe it. And they already are for things like type 2 diabetes. lots of gps are very happy to prescribe it for that because it does make a big difference there um but we still don't so many of these trusts around the country they don't have that wraparound service in in place yet and because it is this new medication and because the extra funding has not really been provided for all of that as well alongside it so it's a it's a difficult one now for the people that are listening to this and i okay i'm understanding it he's mentioned in really interesting called food noise.
42:00And I love the sound of putting noise cancelling headphones on and just not being able to have the interruptions of day to day and feel like I can just go through. Without the drug, how come we approach this food environment? Because the amount of messages that I get on, you know, binge eating and intense cravings and all of the different things that, you know, food is so nostalgic and it can really help heal the pain for certain people. like how can people navigate that without taking grp ones well there are there are so many temptations everywhere so i think the first thing would be when you are going on these weight loss journeys really to kind of prepare like you go for an expedition trying to control that food environment you can control and trying to fill your cupboards with like nutritious foods and and reducing some of those kind of processed junk foods really.
42:56I think planning your meals ahead of time is really really important and what I mean by that is you can go shopping on a Sunday so you don't revert to those default patterns and you know planning even making your lunches for the day so you don't just go to whatever fast food place there is around the corner. I've kind of mentioned about helping control your stress and that can be through exercise things like meditation as well. I would say fourthly, making sure you are eating these really filling foods that do have protein, healthy fats and fibre. And I think another, like, one thing some people do use is something called urge surfing.
43:38So it can be quite an effective technique for some people. So the thing with cravings is often they, like a wave, they peak and then they pass. It's different to physical hunger, which slowly builds over time. So first off, naming what you are feeling. And that often is a craving. Noticing how it feels in your body. And then one thing some people do is, you know, they do a couple of minutes of deep, deep breathing. or they take themselves off for a walk or or listen to some music or read a book or that sort of thing and just and they will often notice that those cravings do do pass over time yeah i think it's about activating the self-soothing system because i think that's what food does right it activates something where you start to feel safe and it's an immediate effect of feeling safe and then all of a sudden that's that feeling goes again because that kind of hit that you had is now has now gone.
44:38And then that's when the feelings of shame creep in. And so, you know, creating some type, I talk a lot about self compassion on the show because I really believe it's missing from so much. And, you know, really crap foods can make us feel really shit about ourselves. You know, that's what the tendency they can have. They can unbalance our chemicals and make our, you know, our glucose go crazy and make us feel heavy and all of those things. And so I think, you know, actually trying to build some self-compassion in yourself is really important during this time too. I think it's completely vital, really, because even looking at the studies, when you associate, um, say you've been to a party and you're eating a cake, if you associate that cake with guilt, then it actually has been shown to lead to further weight gain because you, you know, you punish yourself, really, and then you go, oh, well, what's the point?
45:30And then you may get in these vicious cycles of overeating. So I think just going easier on yourself and saying, oh, I'm moving in the right direction overall, having a little bit of cake here and there, that's not going to harm my overall progress that I've made. So I think it's so important. It's so important. And even think people that are stuck in binge eating cycles to give yourself a bit of a break is really important because you kind of can't undo what's already been done. Yeah. So it's about like, what is the next step forward? That's a way that I always try to speak to clients that kind of come and see me on like, well, what's the next best step that would be correct right now?
46:08Like, what advice would you give to me? That's always quite helpful because we can offer advice quite freely to others. It's quite easy. Offering it to ourselves is pretty hard. no exactly i think being your your inner coach rather than the inner inner critic which we are all our inner critic but would you treat a friend like that no you probably wouldn't you would say you would be reassuring and you would say don't worry about it but but that's not often what we do to ourselves is it so it's true i kind of think if we speak to ourselves i speak to our friends we wouldn't have any friends no exactly it's so true and everyone's just living this internal monologue like oh why can't you do this you're useless and like yeah it's it's not unfortunately it's not like beneficial in the long term and yeah like you say you would be pretty lonely if you spoke to everyone else like that exactly so i'm thinking about you know how long are these people because this is why it's coming into my brain how long are these people on these drugs typically for 10 months well it's a real range and they're definitely not a short-term medication we've mentioned they're not for to get beach body ready they what we do find is so the studies at least show after a year half of people have stopped the weight loss medications and this could be for a range of factors and including the kind of quite high price that a lot of people are paying at the moment because how much they're like 2 500 a month or something in the u.s they are a lot a lot more than four and a half so so yeah no so they're similar like around that so they they have come down actually quite considerably so when they first came out they were up to 2000 a month exactly now they are coming right down even in the us and in the uk you're kind of looking at maybe 200 pounds a month okay oh well that still is you know that's an expensive amount of someone's uh daily uh so monthly um costs so so some people are coming off them because of all sorts of things how expensive they are some of the side effects and and the problem the problem with this is that as we've mentioned when you stop these weight loss medications that that weight regain is actually much more rapid than if you were doing what's a kind of a convention what you call is a conventional diet without weight loss medications how quickly so say people go on it for 10 months, a year, year and a half.
48:31How quickly are people regaining the weight? They are regaining the weight quite rapidly, actually. So with this new generation, you may have lost 15 % of your body weight, but within around 20 months, typically on the studies, you have regained it all. And this is around four to up to eight times faster than the weight regain you would see after a diet where you're not taking the weight loss medication. So it's much more rapid. The other thing is those cardiometabolic markers which come down when you take the weight loss medication, when you lose that weight, so your blood pressure, your cholesterol, your blood sugars, all of these again return to that baseline after around one and a half years, so around 20 months again.
49:18So they do return. And there is a concern, especially if you're taking them later in life. And this is where things like thinking about your muscle is so important. When you're taking it later in life, we've already lost a lot of muscle by the time you hit your 70s. If you're then losing muscle, you might regain some of that fat if you stop the weight loss medications. So it's so important to think of your muscle and do some of these things that can improve it. Yeah, that's really important. Okay, so what percent to help? What did you say? What was the percentage of people that regained their weight?
49:51so it's something like the actual number of people who regain their weight so on average people will regain all that weight after about 20 months but all of the people but not all of the people so when you actually break it down it's something like 80 of of people will will regain their weight so on average everyone has but but there is there is some 20 25 of people who haven't yeah i think it's actually a little bit less it's around 20 percent and many of these people are people who have also made these significant lifestyle changes as well and really focused on improving their nutrition improving exercise all these kind of things we've talked about wow okay so if it's interesting right we started off with you know how rapid and life-changing this can be but then within 20 months with 80 percent of people are regaining back the weight and regaining back you know the the factors that lead to chronic disease like your blood pressure your cholesterol all of those things it kind of just feels like a little bit like a plaster yeah so that's what it exactly that that's what it has um been described as or a band-aid for yeah yeah thank you for making my american audience knows what a plaster is it's like when i say the word knackered.
51:07And they're like, what does knackered mean? They probably know what plaster is, to be fair. Yeah, but yeah, it is, it has been described by some people as this, this plaster, a pretty effective plaster, to be fair. But again, when that plaster comes off, sometimes, well, quite a lot of the time you can get that rebound in your, in your weight and you can regain that weight. So that, that is that is an issue so how do people sustain their way like how does one stop to say we're like okay we've been on this for a year now we're going to stop we're going to come off it what does one do there are there are definitely different options of of what people do um there is uh so i think when you're on these weight loss medications i mentioned the mediterranean style diet that is the ultimate health bullet and it does help keep off that that weight so that's like lots of whole grains good protein tons of olive oil legumes beans all of that type of stuff that's it nuts seeds oily fish yeah like you say lots of olive oil which is um yeah so it's not a low fat diet, and it's kind of dispelled the myth of it just has to be low fat, actually.
52:24And this was compared to a lower fat diet, which had kind of starchy carbs. And they found, with all of these good ingredients and these complex carbs, that's what's important, the things like the whole grains and the beans, it was associated with much lower risk of heart disease, all of these things. So that's one thing you can do. My dad, he popularised the 5-2 diet. How many years ago was that now? That was back in 2012, so a long time ago, 14 years ago. And that was really when lifestyle medicine was in its infancy. Yeah. So the concept of that is five days a week you eat normally, then two days a week you really cut your calories down to between 800 calories and a thousand calories.
53:11And he was able to lose, he was, he was pre-diabetic and he had kind of gradually put on weight as lots of many people do as he approached middle age. And he was, he was approaching the diabetic range and he managed to lose nine kilos and kind of keep that off for the long term doing that. And there's actually a really interesting recent meta-analysis, so that's pooling over 20 studies together that found it was significantly more effective than the kind of traditional diet at reducing body weight and some of these cardiometabolic markers too so that was really interesting and what the 5-2 diet was the 5-2 diet was so one yeah that could be an option for even you know throwing in a few fast days here and there to kind of keep that weight off for for the longer term um and he he set up with my mum the the fast 800 so that was this digital lifestyle program that really helped support people with eating their uh you know following these healthy habits and cooking the right sort of foods that are really beneficial to keep that weight off with lots of filling nutrition as well as kind of guided exercises and guided meditation and it's a kind of really holistic approach so i think in general a digital lifestyle program whatever that is i think it because Because we do have limited resources, I think it's been shown to be a valid option to do it.
54:34I mean, whether it is the Fast 800 or whatever else you want to use that works for you. I think in general, with limited budget, limited money, this is a really, really beneficial way to do it. Well, I think one of the reasons some people find it really helpful, things like the 5.2, is because you know it's not like this kind of permanent calorie restriction. Many people are living this life of this kind of permanent calorie restriction. I can't have that, I can't have this. So they can kind of eat a bit more normally on the other days. So it gives some people a bit more control. And it also makes you think about what foods are filling.
55:16So you kind of fill your food with some of these more more filling yeah more filling foods what would be some examples that you would give on the lower calories for people to get their head around what are those foods that you could have in the day what i would say is things like yeah so having having enough having enough protein so things like yeah chicken with chickpeas and a bit of garlic and um lots of yeah Lots of beans, I think, is really important because that has plenty of protein and fiber. So if you're a veggie, having a kind of bit more of a veggie, veggie chili. And yeah, just eating things like oily fish, all of these sorts of things can make a big, big difference actually.
56:06And they contain all of these protein, but healthy fats as well. um and we do know yeah quite a lot of these um areas where people live a lot longer that is in areas like the mediterranean where they do eat more of this sort of diet whereas in the uk not so much yeah do you worry about the kind of malnutrition if it's on the 800 calories a day or not do you worry more about like the nutrient density that you were talking about or do you think that doesn't affect it if you're really being aware of the calories that you're eating. So once again, that's why it's so important to kind of make every bite count in these circumstances.
56:48So eating these kind of really nutrient-dense foods is so important. Yeah. So I guess the people looking at that, I'm trying to get people to get their head around what that looks like. So would that mean that they would be skipping a meal potentially? Not necessarily. Sometimes it might just be slightly smaller meals. And yeah, so it's not necessarily about skipping meals but having like slightly smaller meals on those days some people might be um you know skipping certain meals but on the whole it's it's just about eating those kind of filling nutrient nutrient dense foods yeah and in smaller portions i guess yes no exactly yeah and so do you see a lot of people come to the program from grp1 drugs there is yeah there are lots of people who are who are doing that and i think it just does provide that extra support really for a lot of people and i think it is just so important to have that extra nutritional support whatever it is and i think also in my in my book food noise i kind of talk about some of these nutritional strategies but yeah whether whatever that extra support is i think it's so important to make sure you are very well informed on the right nutritional and lifestyle strategies and ingrain some of those habits for the long term.
58:09Yeah, I guess I think it's so important to just understand the landscape of food because I don't know if I fully agree with it, but I think exercise is important for your mental health and your muscles and your longevity, but it's not as effective as weight loss as looking at the food itself. And so there's a very famous slogan that you can't outrun a bad diet, which, you know, can be seen either side. But I do think that like understanding the food landscape is really important when it comes to weight loss. Like understanding, and I think a lot of people might think, well, if I go for a run, I can kind of outbalance.
58:47But actually understanding the ratios of the foods that you're having is really key. Yeah. And exercise is just so vital for your overall health. Whereas, as you mentioned, you can't outrun a bad diet, unfortunately. So you can't go eating loads of extra cookies really if you're doing a bit more exercise. But we're now learning exercise and strength training. It's good for not just your heart health, your bones, but also your brain health too. Some of these exercises, for instance, especially uh some of these muscle building um exercises for instance squats um they release something called bdnf which is brain derived neurotrophic factor so this is like fertilizer for your brain and we do know now and many people obviously will feel that after doing exercise that they may have a bit more energy they may have better concentration but we do know actually the science shows that it even can grow different parts of our brain if you started from a very sedentary lifestyle and even start walking for instance then areas of our brain actually do can grow over time so so we know just it is so important to ingrain these things in um and just make make these and it can for especially for things like exercise it can be very simple changes so for instance get out of bed and do five body weight squats if you're really like you know starting from a lower lower base and you haven't done much because there's a lot you can really do from home as well and i think you know gyms are intimidating for a lot of people yeah but we don't want people to be intimidated by gyms no no we want people to be able to walk in there pick up the big weights and be like move out the way exactly they've got to strut their stuff yeah i think it's important i think i used to be that person that was terrified of the gym then i got dr stacy sims on and she totally got that out of my head um she was like don't you pick up those pink dumbbells go to the proper one and it's changed my relationship to it i think it's important so if someone is wanting to improve their metabolic health in the next three months what are the practical steps you're going to give to somebody what i would say is i think it does depend kind of what what base they're kind of coming from so there is a lot of way different ways to lose weight and you know glp ones for some people might be an option for some people living with obesity we also know um and it's not not for everyone but rapid rapid weight loss via kind of a bit of a lower calorie diet we know that the weight you actually lose in the first 10 weeks or so of the of your weight loss journey can predict your longer term weight but things like incorporating activity into your routine is so important.
1:01:42So things, and even thinking about simple things like, instead of getting the train, the tube, driving to work, thinking about cycling to work. Do you want to know a good one that my friend did? This is one that has never ceased to amaze me. And I think, I wish I did this, but I don't have the space for it in my kitchen. but they had cups and he was all about mobility he was very into calisthenics you know where you like hold yourself on a bar and you can do all these crazy things he was like you really want to be mobile so he would put his cups at the bottom of the kitchen so he'd have to bend and squat every time to get there and he was like yeah every time i had to make a like a cup of tea i would bend and pick up my cuff and i was like that's actually such a good point i should do that and i never did it but like making things in your household you know they're like that's what i think about with people in japan how mobile they are they all sit on the floor and they're all kneeling and my friend went to japan recently and she was like it was great but my gosh i had to constantly keep kneeling down to eat food because there's no furniture but they maintain this type of mobility i think this form of like habit stacking like you mentioned is so is so vital.
1:02:56So pairing, you're putting the kettle on and pairing it with an activity. So that could just be a few squats in your kitchen. It could be stretching. To be honest, I'm quite inflexible. I'm quite tall. So I've actually started doing some yoga recently to kind of help with that flexibility. And I was told by the instructor, so when I'm putting on a cup, when I'm putting on the kettle to just sit down in the kitchen and bend over and touch my toes, exactly, to get that flexible movement. But whatever, exactly, my hinge is, I'm flexible in some ways, but my hinge is just terrible. So I have started doing that.
1:03:44But even you can pair things like you're brushing your teeth you're going to do that anyway you've ingrained that habit so you can pair that with after i brush my teeth i i meditate for five minutes and these simple changes can make a huge difference and they can help with your overall health for sure yeah i think it's so key i've started to do mindfulness when i brush my teeth because normally i'm scrolling or like trying to reply to whatsapps but actually if you're meant to be brushing for two minutes which I'm not sure if everyone listening to this is, but if you do, it's actually a really good space because you're like, you can't, you're not meant to be doing anything else.
1:04:18So I try and feel the sensations when I'm brushing my teeth. And, and I think, you know, it's like mindfulness is like going to the gym for your brain, similar to how you brush your teeth. So that's how I try to make that connection. No, that's a really good idea. I'll try that out. Give that one a go. My dad kind of famously suggested standing on one leg while you're brushing your teeth to improve your balance. So just a couple of minutes of, uh, yeah, balance is a predictor of longevity. It is exactly. So yeah, within longevity health, there's even within exercise, there's quite a lot of different, unfortunately, different things to think about.
1:04:53It can keep things interesting at least. So you're doing, you know, you're doing your walking, you're doing your, your cardio, maybe a bit of strength training, and then maybe you're doing a bit of balance exercises as well. So just trying to incorporate that to make it easy, like your friend did with the stretching. And isn't that amazing with the cups? Yeah. I mean, to be fair, he's so flexible that it did make me want to start. Yeah. It's such an interesting landscape that we are finding ourselves in. I find GRP1 is one of the most fascinating medical moments that I've ever obviously lived through, that many of us have ever lived through.
1:05:32I you know you wrote in your book that it's going to reach 100 billion dollars by 2030 which is wild like it's such an exploding industry um I look forward to seeing the update of your book coming um but Jack it leaves me with my final question which is what does live well be well mean to you it's yes it's not about we've talked a lot about about weight here but you know it's not about how much you weigh the numbers on the scale at all it's about your overall health your your your well-being you know your the quality of your life and that a lot of that can come from your your social relationships that's so important keeping up with friends loved ones your family uh you know doing all these extra things like things like mindfulness exercise and eating well all of these things can be so important for your overall overall well-being so i think weight is by far is not the only thing we need to think about well yeah i definitely think it's not it's thinking it's on everyone's eyes and ears and front pages but it's true i think um such a personal topic as well isn't it yeah um such a personal but thank you coming on spreading your knowledge about grp ones and the food noise and you know your fast 800 program we'll put it all in the show notes so people can go and check it out if they want to but um thanks so much for coming on no worries thank you so much
From the publisher
Exciting news - pre-order my debut book
https://linktr.ee/HealthySBTH?utm_source=linktree_profile_share<sid=9db12bc6-b7d3-4df4-bc5c-260e0303792c
You've seen the headlines. You've watched the celebrities transform. Maybe you've even wondered, quietly, if it could be for you. But what is the science really saying?
This week on Live Well Be Well, I sit down with Dr. Jack Mosley, GP registrar, and author of Food Noise. Jack brings a perspective that is honest, nuanced, and completely free of hype. We get into what these drugs can genuinely do, who they are truly for, and why taking them without lifestyle support is like putting on noise-cancelling headphones without ever learning to listen to yourself.
Here's What We Dive Into:
- Why up to 40% of weight lost on GLP-1 medications can come from lean muscle, not fat, and why that matters more than the number on the scale.
- What "food noise" actually is and why silencing it with medication is only half the story.
- The 80% reality: why most people regain all their weight within 20 months of stopping and what the 20% who don't have in common.
- Why these are not cosmetic medications, who they are genuinely for, and the real risks of microdosing without clinical need.
Love,
Sarah Ann 💛
***
Want to put what Jack shared into practice? The Fast 800 combines intermittent fasting, nutrition, and guided lifestyle support in one place. Co-founded by his father Dr. Michael Mosley. Try it free for 7 days:
👉 www.thefast800.com
***
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Fat Loss, Metabolism & The Myth Holding You Back | Dr Andy Galpin
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Highlights
00:00:00 Intro00:01:45 The obesity crisis: how we got here and what's driving it
00:04:10 The string test: a simple way to assess your metabolic health
00:06:30 Muscle loss on GLP-1 medications and the stat no one is talking about
00:10:20 Benefits of GLP-1 drugs: heart disease, sleep apnea, and beyond
00:12:00 Food noise explained and how these drugs work like noise-cancelling headphones
00:15:00 GLP-1 and addiction: alcohol, opioids, and the reward system
00:20:30 Side effects, hair loss, and the dangers of unregulated sources
00:23:30 Microdosing Ozempic: what you really need to know
00:35:00 Shame spirals and the role of self-compassion in sustainable change
00:41:00 Managing cravings without medication: urge surfing and habit stacking
00:47:00 Weight regain after stopping: the 20-month reality check
00:50:30 The Mediterranean diet, the 5:2, and the Fast 800 programme
01:05:30 What live well, be well means to Dr. Jack Mosley
***
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