How to Change Your Brain's Destiny Before It's Too Late | Dr. David Perlmutter – EP 809

27:40Por ejemplo, en large studies de la enfermedad de la enfermedad, el riesgo de un pobre es dramático aumentado si se han sido un tipo 2 diabético a la hora de la enfermedad. Tu hospitalización será más largo y el work w impairment will be greater if you're a diabetic across all levels of injury in comparison to not being diabetic. Why? Type 2 diabetes is a profound metabolic challenge to the brain's microglial cells. They don't shift back as readily to being in their healing environment. So the main task in terms of recovering from a head injury is shifting those microglial cells back to being supportive as opposed to being destructive.

28:30Their function, whether they're supportive or destructive, depends on their metabolism, how their mitochondria are working, for example. It's why things that target the mitochondria, like hyperbaric oxygen, for example, are so effective in treating brain injuries, treating head injuries. It's why when an individual has a brain injury, we want to use the la dieta, por ejemplo, porque eso brindó la mente y la metabolismo de estos brain immune cells de la vida online. Es por eso, con la cabeza de la cabeza, queremos controlar la sangre de la sangre como lo que podemos. Es por eso, queremos reducir otras sources de inflamación como lo que podemos.

29:10¿Quién sabía que en la cabeza de la cabeza, es importante que el objetivo de la cabeza brain connection to evaluate the function of the microbiome in the gut to help reduce inflammation to set the stage for better outcome better recovery we certainly know that we've been doing that in individuals with long covid it's an exactly similar scenario we want to do everything we can to improve metabolism of the microglial cells so they will revert back to being brain supporters, o lo que se llama en el libro, brain defenders. Just a follow-up question on traumatic brain injuries. I know as I was going through my treatment for this, given that a number of these happened in combat situations, the doctors had a very difficult time trying to determine, was it PTSD that was causing the long onset of symptoms that I had, or was it strictly related to brain trauma itself.

30:13Why do those two conditions overlap so much, and does what we're talking about here play into it at all? The answer is 100%. When we examine patients with a variety of disorders using a very sophisticated type of research tool called a TPSO PET scan, this is a scan that is able to determine the level of activation of these microglial cells, these brain immune cells. When they're active and being destructive, the TSPO scan lights up. So the TSPO scan is positive, as you would expect, in Alzheimer's, in Parkinson's, in MS, but it's also very positive in PTSD and also in head trauma and even in long COVID.

31:03So the point is that these are issues in which there is this fundamental shared mechanism that once these microglial cells become activated, we have a variety of manifestations, things like PTSD, major depressive disorder, and frankly, even increased risk for Alzheimer's and even Parkinson's. One would wonder, for example, why head trauma would put you at risk for Parkinson's. What could the relationship possibly be? Bueno, lo que es Muhammad Ali. Es que es called pugilistic, que significa un boxeo, un Parkinson. Cuando te activas los microgliales, puede tener un montón de manifestaciones. En Parkinson, un motor manifestación.

31:44En PTSD, un emocional manifestación, un psiquiatra manifestación. Un mood disorder, un major depresor de disordar. Y incluso Alzheimer. As you mencioné briefly, ahora que has tenido multiple experiencias de trauma, You were concerned about beta amyloid. Obviously, you were thinking about the fact that you were at risk for increased risk for developing Alzheimer's disease by virtue of your head trauma. That's well documented, not anything you're the only one who thought about. Why does it happen? It happens because of activation of the microglial cells. So your original question to me is, why this book?

32:25Why now? porque unites todos estos problemas de desesperación de problemas que hemos pondido por muchos años a la fundamental entender que lo que está pasando en Alzheimer, en PTSD, lo que está llevado a la cabeza, lo que causa Parkinson, es un activo de la mente de la mente de la mente de la mente de la mente de la mente de la mente de la mente de la mente de la mente. It opens up a lot of potential, I think, to throw a very wide net in terms of paving the way for better brain health moving forward. David, I remember having a conversation with my grandparents. They had been smokers, like many people of their generation had been for many years, probably a decade plus.

33:09And then the Surgeon General's warning came down on the impacts that cigarette smoke could have on each of them. y ambos pretty much quit cold turkey overnight, never smoked again. Where I'm going with this is a number of years ago I started to do more and more research on alcohol and I started to realize that alcohol was having a profound impact as well and it's getting more and more documented but one of the biggest areas I was concerned about was the impact that it was having on my sleep because it was causing me, I'd go to sleep and I was using it to help me with my PTSD. But what would end up happening is two, three o 'clock in the morning, I'd wake up completely awake.

33:58And so it was having a negative impact, not only on that, but on other areas of my life. So I have been alcohol free now for over three years. And I was talking to Daniel Amen about this because it's like, I feel fully charged now, fully awake every day that I get up. It's so drastic a change in how I feel. But alcohol is something you explore in the book as well. And maybe you can touch on it. Yeah, it's funny because I did an interview for Newsweek just yesterday. It actually came out yesterday morning. They said, what are the things that this neurologist, the six things that you would never do?

34:40And alcohol is one of those. Not that I wouldn't have a glass of wine from time to time, but alcohol is an issue at multiple levels. A, it is a direct neurotoxin. It is toxic to neurons, no matter how you slice it, i.e., whether it's scotch or red wine. We used to say, well, the epidemiology studies demonstrated that one glass of red wine for women, two glasses per day, actually was associated with a reduced risk for Alzheimer's disease. I think that's been reassessed and has been demonstrated to be really, no pun intended, self-serving. The reality is that no alcohol is the best choice that you can make.

35:17The direct effects of alcohol being a toxin, number two, as you characterize, the effects of alcohol on sleep are significant. We talked about why that is so important from an inflammation perspective, from a metabolism perspective. And number three, alcohol has bad effects on the gut microbiome. que aumenta la inflamación en la cuerpo que los células de la cerebrina, los microgliales, responden a Así que Dan Amon, he ha tenido muchas a dinner con Dan Amon y he es correcto que la mejor choice es nada en relación con alcohol Y si alguien tiene una bebida once en un momento creo que no es un gran problema pero el idea de consumir alcohol en un día creo que es un gran peligro y un peligro en relación con la salud y es uno de los fundamentales aquí I think that ultra-processed foods represent a dramatic risk to brain health, as does what we call sedentarity, being sedentary and not moving around.

36:14These are huge issues. We talked about sleep, but we need to talk about diet. But these are the pillars of brain health. And we live in a world, I think, John, that really wants us to believe the messaging that we can do anything we want with our lives. Drink whatever you want. Don't exercise. Eat the stuff that is advertised. Y cuando se ha un problema con el problema, que es tarde en el juego, pues, se va a ser un problema para ti. Que no existe. No hay ninguna ninguna farmacéutica para Alzheimer's disease, como tú y yo tuvimos esta conversación a este momento. Y, de nuevo, este cochrane análisis que se dio este año, looking a la efectividad de los drugs que target exactamente lo que mencionó antes, beta amyloid, found that the drugs that are FDA approved to reduce beta amyloid in the brain absolutely reduce beta amyloid in the brain.

37:09No doubt about it. They're monoclonal antibodies, but do they have any significant effect on the downward course of Alzheimer's? They do not. This is the gold standard approach to studying a question. In this case, the question ¿Qué es lo que se puede hacer para Alzheimer? Se evaluó 17 estudios de 20 ,342 estudiantes. Se han hecho que los drugs no funcionan y que son significantly peligroso como se relaciona a la sangre y la sangre. ¿Qué es lo que se puede hacer? Bueno, creo que, como hemos hablado ya, estamos en un situación donde sabemos que podemos evitar este problema significantly. And even more importantly, we now see interventional trials, meaning treating Alzheimer's patients with lifestyle intervention that targets the brain's immune system and having results that are unparalleled.

38:05There's certainly no drug that even comes close. May I quote one study for you done by researchers Rudolf Tanzi and Dean Ornish at Harvard, a study, only 51 patients, small study, I agree, Pero estos son los pacientes con Alzheimer's disease que se han desarrollado en un 20-week program. ¿Qué ha sido el programa? Vamos a cambiar tu diet, vamos a hacer ejercicio, y vamos a reducir el stress en tu vida. ¿Y qué han encontrado? Estos son los pacientes en 20 weeks de tiempo que hubiera otherwise continuado a decline. Eso es lo que es expected de una diagnosis de Alzheimer's. es más. Seventy percent de estos pacientes either se estabilizó o had improvement en su cognitive function.

38:51Y esto no es un drug. Y no es patente. Y no es requer FDA approval. Think about that. Esto no es algo que se escucha sobre en TV como un advertenimiento para un producto que alguien puede own. Así que cómo estos

39:31Let's imagine... We have someone listening to us today. They're 40 years old. They're busy. They have kids of different ages. They're sleeping poorly. They're eating too much ultra-processed food. They're stressed out. Their work and family obligations are prohibiting them from exercising as much as they need to. And they're hearing you and I talk. Where would you suggest they start? Not with trying to overhaul everything, but with one thing. I think the one thing, the place to start would be to embrace the understanding that you are controlling your brain's destiny. That's step one, because if you don't get that step, nothing else will follow, right?

40:24And you bring up an incredibly valuable point, and that is that Alzheimer's, the cognitive disfunción que los niños se experimentan en sus 60 y 70 se empieza en los 30 y 40 porque es cuando los metabólicos que te han mencionado se han mencionado y se afecta a los que se afecta en los cerebros de la mente que van a apoyar a la funcional brain o paga la forma para la mente de decline en los 30 y 40 que los metabólicos se enfrentan a lo que se llama los microgliales So, that's who needs to be listening. Because frankly, when individuals have already been experiencing cognitive issues and become forgetful of Wi-Fi codes, grandchildren's names, phone numbers, etc., we're well down the continuum.

41:18And I prefer not to use that term continuum. Continue means it's going to continue. Let's just abandon that term, mea culpa. I'd say that the fundamental take-home message is to really clean up your metabolic house and in your 30s and 40s, in your 20s, in your teens, when you're a newborn, perhaps even in utero. When does it begin? We know that inflammation is increased in children born by C-section, as is autoimmunity in comparison to children born, newborns by a vasilar delivery. So when does it begin? Pero, también, yo diría que sí, tú eres en target, la 30, 40 y 50 años. Cuando miras a la salud de la población de la población aquí en América, es muy preocupante.

42:06Sabemos que en los adultos de los adultos, 60 % de los calores son derivados de ultra-processed alimentos, dramáticamente associated con el alto Alzheimer. por la virtud de los efectos de estos alimentos en la salud, la salud, la salud y la inflamación. Así que hay que suceder. Así que, a ser faires para usted, ¿qué fue ese punto de hook? Y para que este persona se acercie a la mejor vida de la vida de la vida de la experiencia. Y voy a responder en un poco de un cagy de manera, porque yo fui a la pregunta a un poco de los libros. y a mí me es que lo que hay enramp works porque lo que lo que hay enramp es lo que hay para el camino solo just el hecho que he empezado ejercicio no just el hecho que he changed mi diet no just el hecho que he pagó strict atención a la buena sleep whatever it may be will then set the stage for wanting to do the rest of the program I think it's Es la misma manera que se approache a cualquier life change.

43:17Yo often tell people que yo often think about life as on five. You're sitting on a bunch of stools. What's on those stools could be whatever priorities you want to put on them. For me, I put my emotional health, my physical health, my mental health, etc., my relationship health, etc. But typically, for most people, some of those pillars are strong and some of those pillars are weak. So you basically have to look at your pillars and pick one to start working on. And then what I have found in my own life and what ends up happening to everyone is once you pick one and start working on it, you naturally gravitate to the other pillars.

43:58Exactly. I just need one on-road. Exactly. But interestingly, you didn't mention cognitive health. You said emotional health, spiritual health, physical health. Pero como muchos, no piensan que pueden influenciar su salud. Habla de Dan Amon y saben que es no es cierto. Que nuestros choices son fundamentales en relación a la salud. El riesgo de ser demente en América de los 65 es 1 en 9. Es 11 % de los 65 o menos de los 65 es demente. Eso es sobering. Y, por lo que se ha hecho, cuando se ha hecho el programa. John Kennedy dijo que el tiempo de fixar la ropa es cuando el sol es brillar. Y, por lo que es por lo que yo estoy agradecido con este tiempo con hoy.

44:47Porque quiero este message para que se ha hecho. Tú went through it con tu grandfather. Yo went through it con mi padre. Y, por lo que es horrible. Y, por lo que no quiero dar mis hijos a través de eso. Y, por lo que los Alzheimeres pacientes, se han transicionado a punto donde no entiendo lo que está pasando. on. It's the loved ones that are so impacted by it. And we can do better. This is an emotional issue. It's a financial issue. We're spending$360 billion in America today to care for Alzheimer's patients. And when you look at that number and you look at, there was a recent Lancet report in 2024 that said, if we could look at 14 different lifestyle variables and address them, that the El número de alzheimer's patients Would be reduced by 50 % My mission would be I'd be happy at 10 % I'd be happy at 1 % If 1 % of people Won't have to go through What I went through In terms of being a family member A loved one To me that's a good day's work I certainly want to go for higher than that But it's just It's so black and white clear que el cerebro es completamente responsable a los resultados que hacemos cada día.

46:04Y, John, lo que lo que estás diciendo, que estos son busy personas, y tienen niños en casa, y tienen un trabajo de trabajo, y tengo que ir a 6 de la hora, y voy a comer algo, y voy a comer algo, y voy a comer algo, y voy a comer. Start somewhere. Train for an event. Pay atención a su sleep. Cut back on the packaged foods. Do your best to exercise. Even weekend warriors derive significant benefit from exercising even two days a week. So there are opportunities. I want exercise to go not from finding the time, but to making the time. David, if the evidence is so compelling and so many new articles are coming out every single week, why hasn't it changed clinical practice yet?

46:47It has, but not to any significant degree. Y creo que es muy difícil de mover el standard de la práctica en América y en los países de los países de la práctica de la práctica de la práctica de la práctica de la práctica de la práctica.

47:20That's the way it's done. To spend the hours that it takes in giving people this information, which is far more important and far more valuable, in my opinion, is not remunerative. It is not remunerative as it relates to pharmaceutical remuneration and is difficult. And to be fair, most medical doctors do not have much training as it relates to lifestyle interventions. I, for one, had zero training during my medical education que se ha dado a nutrición, no una hora. Si eres un chiropractor, te get un montón de nutricional training y creo que es tan valioso. Si vas a veterinario, a veterinario, te get un montón de información sobre lo que se puede enseñar a sus hijos, lo que sea que sea que sea que sea.

48:08I tell the story de, many años ago, our dog was losing its fur. We took Tico, our dog, to the vet, my wife and I. And the first question she asked us was, And I was stunned. I thought, why do I never ask that question to my patients in my office? Because people would look at me funny, right? Why would you be asking what I ate? I'm here to take care of my headaches. Well, your headaches may be from the foods that you're eating. Who knew? So medical practice is a situation of old habits dying hard. As I'm hearing you talk more and more, lo que escucha es el Esos su artículo son y se mostramos dos عليه y los diferentes tipos de alimentos que creen para ellos.

48:59Es que es el correcto modo de pensar en eso. Sí, y se ve en el artículo sobre el sleep y en el artículo sobre el ejercicio, sobre varios alimentos. Vitamin D ha sido en el news en los últimos dos meses por buenos días. Y creo que los artículos están escrito sobre estos únicos hacks, no me gusta usar ese termo, pero en particular, que pueden hacer. Y el objetivo de este libro es presentar las muchas de ellas como puedo en la most understandable presentación que pudiera, así que la gente puede hacer como muchas de ellas como se sienten comfortable. Y yo reconozco que no puedes hacer todas ellas.

49:35Podemos cambiar la mente de la trayectoria. Cada uno de nosotros puede hacer eso. Tenemos los tools. Es una cuestión, como yo creo, caracterizó antes, de implementación. Pero creo que la idea de implementación es más poderoso y más meaningful cuando entiendo la científica para qué es que voy a aumentar mi ejercicio, o que voy a no beber cola y fruta. ¿Por qué? Porque de la sangre contento y cómo es que está afectando la brain's immune cells y cómo el estudio ha demostrado que, sí, la consumo de fruta, nos hemos habido a todos, drink una glass de OJ o apple juice cada día, pero los que drinken con más alta nivel de fruta, la consumo de fruta, tienen un mayor riesgo de desarrollar Alzheimer's disease, significantly higher, and stroke for that matter.

50:24David, I always like to turn this around. You've been talking a lot to the audience about the changes that they could do in their life. How has that research that you've been talking about throughout the interview changed what you're doing in your own life? I think for me, what's been so powerful is the new knowledge that I have en términos de cómo cada uno de estos cosas que he estado haciendo por un tiempo, cómo se convierte en el sistema de la salud. Es encargarse a mí. También me encargarse a mí a mantener una mente abierta sobre las cosas. Porque las cosas que se presentan cada día, hay que Google searchar sobre las cosas que permiten a ser asociados a la persona que se puede con nuevos anuncios sobre nuevos findings cada día.

51:14Mi programa cambia. ha cambiado. Es absolutamente flexibullo y open a new suggestion. I, many years ago, subscribed to a fully vegetarian diet. That has changed. I don't do that now, though my diet is plant forward. I eat mostly plants, but I do eat animal products. So I think that's important and I've been called out for that and people say, well, Dr. Perlmutter, you told us several years ago one thing and now you're saying something a little bit different. Y mi esperanza es que la gente se pueda finalmente a un lugar de entender que cuando la messaging cambia, la cambia porque la scientific underpinación ha cambiado.

51:52Como te preguntó antes, alcohol. Yo estaba de la camp que decía una glassa de vino para las mujeres, dos glasses de vino per día para las mujeres. Eso es lo que la science shows. Bueno, la science no se muestra anymore, así que ha cambiado esa mensaje. Para mí, la idea es que mi programa, mi programa de que me quiera físicamente y cognizantemente intacta, I think will keep changing as the science dictates. One thing I did want to spend a little bit of time with you on is, I remember about 15 years ago, I went to my primary care provider and I told him that I was really big on taking supplements.

52:29And he looked at me and he said, John, you are completely wasting your money. The reason I was taking them is because of the inflammation that I had on my brain, I had researched things like magnesium and its importance to my sleep. I had researched omega-3s and its importance in treating some of the inflammation that I had along with other things. And you spend an entire chapter on these supplements. Para alguien que está escuchando lo que mi doctor ha dicho a mí, ¿por qué decidió que decidió a la parte de la parte de este? Bueno, lo que significa el nombre, ¿suplement? ¿Suplement significa en adicion de?

53:15¿Es there un requerimiento para tener algo en adicion de los alimentos que te eat? Y mi respuesta es, sí, ¿por qué? Porque la calidad de la calidad no es como la que se usedía. y el nivel de confrontación de nuestros cuerpos por nuestros

53:55nivel a la increased risk de Alzheimer's es sound. Most recently, a en 2 weeks ago, a fascinating report was published demonstrating that low levels of vitamin D are associated with a significantly increased level of an Alzheimer's marker called Ptau-217 we talk about in the book. We don't talk about this relation because it wasn't even announced at that point. I didn't have that information. So, ¿sí que me dice que hay un lugar para tomar vitamina D? Sí, si hay un nivel de vitamina D. So, lo que usted ha escuchado me decir es, no estoy haciendo un recomendación de la palabra. Todo el planeta debe tomar vitamina D.

54:37Lo que estoy diciendo, si tu vitamina D nivel es menos que lo que debe, entonces necesito que tu vitamina D nivel de un nivel de un nivel de la temperatura. Y si alguien dice que no necesito de suplentes, That statement shouldn't be made until you check. What is your vitamin D level? What is your intracellular magnesium level? What is your homocysteine level? That's a marker of the functionality of B vitamins in your body. Higher levels of homocysteine are associated with Alzheimer's risk. My homocysteine levels were elevated because of a little bit of a genetic quirk that I happen to possess, as does about 25 % of Americans.

55:18Therefore, I need more vitamin B complex of a special type called methylated B. I would never have known that if I didn't check my homocysteine level. My vitamin B12 level is where it needs to be for good brain function based upon blood testing. So I think that supplementation is very important. There are some supplements that are now a little bit edgy, but have been determined to be helpful with respect to the brain's immune cells. They are something called dihydromiracetin and rosemiric acid. Those are a little bit out there, but they hold great promise, in my opinion, to help A, reduce inflammation, and B, help the shift of the brain's immune cells away from being supportive to being destructive.

56:03We don't want that to happen. These supplements hold promise in that regard. And I will say, after that section in the book, we talk about future-looking technology, even some really exciting things that are on the near-term horizon that target the microglial cells that have already been demonstrated to be effective in Alzheimer's treatment with Alzheimer's human patients that are not drug-related. So what I'm seeing is a massive shift in the research, looking away from the beta-amyloid hypothesis. It's only a hypothesis towards the idea that these microglial cells hold great promise with fascinating research being published now on a virtual daily basis that is really going to set the stage for us to ultimately keep brains healthy and even treat this devastating condition.

56:58And the book goes into a ton of different things from wearables to different supplements that you should consider taking. What I ended up doing is I ended up firing that primary care physician and I started to go see a DO who ran a whole battery of tests. I functioned it. Run, yes, is a sponsor of mine. So that's what I use now to help do these things. But it was the first time in my life that anyone had ever tested all these different levels on me. Otherwise you're shooting in the dark. Y luego tienes que ver si me hace. Y de todo el modo, os Viktes se pueden kalian pero. toary mantra, ahora te testes y miшь lo que tiene que hacer dentro de dil meets.

57:47Bringiendo tu niveles para ponimiento optimal para BBC. Vale yической por poder muscles. Oằngles la medicina de la otra, discomfort las cosas tenemos ya. Eine低 n�로 enelle için, defensa en la omega 3, Low vitamin D, not enough B vitamins as it relates to homocysteine, low levels of B12. We've known about that for decades. So good on you. That is just what I'm looking for. David, we've talked a lot about many different things today. The last thing I did want to ask you about is the GLP-1s and what your thought is about them and everything we've been discussing. Well, GLP-1s are the peptide du jour.

58:28Everyone wants to talk about peptides and feels that there's a place for peptides. And as it relates to GLP-1s, this is without question the most powerful metabolic regulator ever conceived. And I'm saying that in a positive way, but I'm going to need a moment to unpack all of this. So the most powerful inroad to metabolic health, bar none, are these GLP-1 agonist drugs. So, in the consideration that these diseases we are talking about are metabolic at their root, therefore affecting the brain's immune system, which is very sensitive to metabolic issues, might there be a place for regulating these GLP-1s or using the GLP-1 drugs as it relates to neurodegenerative conditions because of their effects on metabolism?

59:20The answer is, in my opinion, yes, there is. Let me give you an example. En 2024, en el New England Journal de Medicine, fue un estudio publicado usando un agonist drug para tratarse de pacientes con Parkinson's disease. Hay 151 individuos randomizados que either received placebo o a agonist drug for a year. Y they followed these individuos a standard scale. What they found was really quite remarkable that in the untreated group o el grupo recibiendo el placebo, se desplieguen, como uno de los esperamos, en un año a la resultado de su Parkinson. En el grupo recibiendo el GLP-1 el grupo de Parkinson's de la disabilidad no se desplieguen.

1:00:07Se desplieguen y se desplieguen y se desplieguen, cuando miras la gráfica y la números, se desplieguen. Es el primer momento en la historia que Parkinson's se desplieguen y se desplieguen. Sí, tenemos que tratar la enfermedad de los problemas. La tremor, la rigidez. Los hechos de los 40 años. Y no hay duda. Pero no hemos estado tratando el fuego. Solo tratando el fuego. Así que la droga de GLP-1. Las que holden gran promise. Así que, como se trata de la Parkinson's study, 48 % de los personas tenían significant gastrointestinal side effects. Así que más trabajo tiene que ser hecho. Creo que hay gran promise.

1:00:51As relates to Alzheimer's, a recent trial called the EVOKE and the EVOKE Plus trial used an oral form of semaglutide. And it was a one-year study done at multiple institutions, involved 3 ,800 individuals, and they did not reach their endpoint. These are patients with Alzheimer's disease. There was no meaningful endpoint improvement in or stabilization of their cognitive function. However, a measurement of inflammation that you had when you had the function health test Called C-reactive protein, measures inflammation Was reduced by around 30 % That is important It means that there is a signal here And that maybe we need to do this over a longer period of time Maybe we need to do a study that is using intravenous Or injectable form of GLP-1-negative drug que se puede cruzar el bloqueo-brain barrier.

1:01:48Porque, remember, este fue un oral form. Pero, quiero verlo en la intervención en términos de la diferencia. La diferencia de la diferencia es far menos que el alzheimer's drugs. Pero no se ve el beneficio en términos de un oral form, pero un gran beneficio en términos de la injectable form, en la parque de Parkinson. Así que creo que hay un gran promise ahí. It hasn't entered the mainstream toolbox as yet. But my mission is to embrace whatever is going to help people and not have a meaningful side effect profile. Face it, Alzheimer's is a uniformly fatal disease. So using a GLP-1 agonist drug, if it helps slow it down or even stabilizes it and proven to be effective, I would be in.

1:02:39David, I highly recommend Brain Defenders. Harness the power of your immune cells to protect your brain for life. This episode will be coming out during its launch week, and I'm so glad this book is coming out in the world. You've got a great podcast, other awareness things that you're doing. Where's the best place for people to capture all that if they want to go there? I'll get there in a second, but let me just say thank you. I appreciate this opportunity. I am happy the book is getting out to the world 16 countries already are going to publish it So it's a global problem And as the western lifestyle spreads around the world We're seeing in tandem rates of Alzheimer's increasing as well So I guess the best place to find me is drperlmutter.com drperlmutter.com The website for the book is There's all kinds of things that people get when they buy the book The book is called Brain Defenders And the website is called braindefenders.com so that's where people can get more information but again, I appreciate your time today John and having me on the program It was my honor I've wanted to have you on for so long so I'm glad we could finally do this Thank you so much for joining us Thank you for having me I hope today's conversation with Dr.

1:03:53David Perlmutter gave you a new perspective on something we have more influence over than we realize the future of our brains Our brains are constantly respondiendo a la environment que crea para ellos. Y como David le ha dicho, la choices que hacemos hoy shape lo que viene. Si hoy conversamos con la conversación resonated con ustedes, me gustaría ver tu biggest takeaway. Share it con me en Substack, LinkedIn, o Instagram. Y si conoces a alguien que puede beneficiar de esta conversación, send them this episode. Si no hay todavía, por favor de la show en Apple Podcasts, Spotify, o our YouTube channels so que no se pierda un episodio.

1:04:32Porque este Friday, I'm doing something a little diferente. Instead de nuestro solo episodio, I'm bringing you a conversation con actor, entrepreneur and father Josh Dumal. We talked about something that fits perfectly with our current series. How the environments we create can shape who we become. Josh shared why getting away from the noise of Hollywood helps him feel more like himself and how becoming a father again completely changed his definition of success. Creo que es realmente Lo que es lo que es lo que es Tengo que sea como si es aquí Estoy totalmente present Estoy totalmente en el momento No estoy pensando en el momento Pero aseguro que todo es funcionar Porque life se está mejor Y creo que es lo que puede Lowerar la blood pressure No estoy pensando en el resto Other que lo que estamos haciendo Aquí en el momento Hasta luego, remember La environment you're creating today Es helping shape the person Y el brain you'll have tomorrow.

1:05:30I'm John Miles, and as always, stay curious, stay intentional, and stay passion-struck.

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